Journal Article
. 1999 Mar; 96(6):2982-7.
doi: 10.1073/pnas.96.6.2982.

Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes

W W Overwijk 1 D S Lee  D R Surman  K R Irvine  C E Touloukian  C C Chan  M W Carroll  B Moss  S A Rosenberg  N P Restifo  
Affiliations
  • PMID: 10077623
  •     46 References
  •     99 citations

Abstract

Many human and mouse tumor antigens are normal, nonmutated tissue differentiation antigens. Consequently, immunization with these "self" antigens could induce autoimmunity. When we tried to induce immune responses to five mouse melanocyte differentiation antigens, gp100, MART-1, tyrosinase, and tyrosinase-related proteins (TRP) 1 and TRP-2, we observed striking depigmentation and melanocyte destruction only in the skin of mice inoculated with a vaccinia virus encoding mouse TRP-1. These mice rejected a lethal challenge of B16 melanoma, indicating the immune response against TRP-1 could destroy both normal and malignant melanocytes. Cytotoxic T lymphocytes specific for TRP-1 could not be detected in depigmented mice, but high titers of IgG anti-TRP-1 antibodies were present. Experiments with knockout mice revealed an absolute dependence on major histocompatibility complex class II, but not major histocompatibility complex class I, for the induction of both vitiligo and tumor protection. Together, these results suggest that the deliberate induction of self-reactivity using a recombinant viral vector can lead to tumor destruction, and that in this model, CD4(+) T lymphocytes are an integral part of this process. Vaccine strategies targeting tissue differentiation antigens may be valuable in cancers arising from nonessential cells and organs such as melanocytes, prostate, testis, breast, and ovary.

Tumor immunity and autoimmunity induced by immunization with homologous DNA.
L W Weber, W B Bowne, +7 authors, A N Houghton.
J Clin Invest, 1998 Sep 17; 102(6). PMID: 9739060    Free PMC article.
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.
A M Thornton, E M Shevach.
J Exp Med, 1998 Jul 22; 188(2). PMID: 9670041    Free PMC article.
Highly Cited.
Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis.
D Olivares-Villagómez, Y Wang, J J Lafaille.
J Exp Med, 1998 Nov 17; 188(10). PMID: 9815266    Free PMC article.
Immunity to methylcholanthrene-induced sarcomas.
R T PREHN, J M MAIN.
J Natl Cancer Inst, 1957 Jun 01; 18(6). PMID: 13502695
Highly Cited.
Antibodies to normal human melanocytes in vitiligo.
G K Naughton, M Eisinger, J C Bystryn.
J Exp Med, 1983 Jul 01; 158(1). PMID: 6345714    Free PMC article.
Unique murine tumor-associated antigens identified by tumor infiltrating lymphocytes.
R J Barth, S N Bock, J J Mulé, S A Rosenberg.
J Immunol, 1990 Feb 15; 144(4). PMID: 2303716
Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.
M Zijlstra, M Bix, +3 authors, R Jaenisch.
Nature, 1990 Apr 19; 344(6268). PMID: 2139497
Highly Cited.
Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.
R H Whitham, D N Bourdette, +4 authors, H Offner.
J Immunol, 1991 Jan 01; 146(1). PMID: 1701788
Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.
M J Grusby, R S Johnson, V E Papaioannou, L H Glimcher.
Science, 1991 Sep 20; 253(5026). PMID: 1910207
Highly Cited.
A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.
I J Jackson, D M Chambers, +4 authors, V Hearing.
EMBO J, 1992 Feb 01; 11(2). PMID: 1537334    Free PMC article.
A fail-safe mechanism for maintaining self-tolerance.
S Guerder, P Matzinger.
J Exp Med, 1992 Aug 01; 176(2). PMID: 1386876    Free PMC article.
Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice.
H Yagi, M Matsumoto, +3 authors, M Harada.
Eur J Immunol, 1992 Sep 01; 22(9). PMID: 1516628
Specific tolerance to an acetylcholine receptor epitope induced in vitro in myasthenia gravis CD4+ lymphocytes by soluble major histocompatibility complex class II-peptide complexes.
M W Nicolle, B Nag, +4 authors, J Newsom-Davis.
J Clin Invest, 1994 Apr 01; 93(4). PMID: 7512979    Free PMC article.
The role of tyrosinase in autoimmune vitiligo.
Y H Song, E Connor, +3 authors, N Maclaren.
Lancet, 1994 Oct 15; 344(8929). PMID: 7934446
The tyrosinase gene family--interactions of melanogenic proteins to regulate melanogenesis.
A Winder, T Kobayashi, +4 authors, V J Hearing.
Cell Mol Biol Res, 1994 Jan 01; 40(7-8). PMID: 7787879
Requirement of CD4+ T cells and antigen-presenting cells for primary in vitro generation of CD8+ cytotoxic T cells against Ld-binding self-peptide p2Ca.
H Wada, T Ono, +2 authors, E Nakayama.
Immunology, 1995 Apr 01; 84(4). PMID: 7790038    Free PMC article.
Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor.
E A Walter, P D Greenberg, +4 authors, S R Riddell.
N Engl J Med, 1995 Oct 19; 333(16). PMID: 7675046
Highly Cited.
Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.
I Hara, Y Takechi, A N Houghton.
J Exp Med, 1995 Nov 01; 182(5). PMID: 7595233    Free PMC article.
A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours.
Z K Pan, G Ikonomidis, +2 authors, Y Paterson.
Nat Med, 1995 May 01; 1(5). PMID: 7585097
T-cell immunotherapy of tumors by adoptive transfer of cytotoxic T lymphocytes and by vaccination with minimal essential epitopes.
C J Melief, W M Kast.
Immunol Rev, 1995 Jun 01; 145. PMID: 7590825
Review.
Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.
K R Irvine, J B Rao, S A Rosenberg, N P Restifo.
J Immunol, 1996 Jan 01; 156(1). PMID: 8598468    Free PMC article.
CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.
M G von Herrath, M Yokoyama, +2 authors, J L Whitton.
J Virol, 1996 Feb 01; 70(2). PMID: 8551565    Free PMC article.
The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.
R P Junghans, C L Anderson.
Proc Natl Acad Sci U S A, 1996 May 28; 93(11). PMID: 8643606    Free PMC article.
Highly Cited.
Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.
F Di Rosa, P Matzinger.
J Exp Med, 1996 May 01; 183(5). PMID: 8642325    Free PMC article.
The expanding universe of T-cell subsets: Th1, Th2 and more.
T R Mosmann, S Sad.
Immunol Today, 1996 Mar 01; 17(3). PMID: 8820272
Highly Cited. Review.
Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy.
S A Rosenberg, D E White.
J Immunother Emphasis Tumor Immunol, 1996 Jan 01; 19(1). PMID: 8859727
Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE).
V Kumar, K Stellrecht, E Sercarz.
J Exp Med, 1996 Nov 01; 184(5). PMID: 8920851    Free PMC article.
Immune response to a differentiation antigen induced by altered antigen: a study of tumor rejection and autoimmunity.
C Naftzger, Y Takechi, +3 authors, A N Houghton.
Proc Natl Acad Sci U S A, 1996 Dec 10; 93(25). PMID: 8962137    Free PMC article.
T cell selection and autoimmunity: flexibility and tuning.
P S Ohashi.
Curr Opin Immunol, 1996 Dec 01; 8(6). PMID: 8994860
Review.
Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma.
M B Bloom, D Perry-Lalley, +4 authors, J C Yang.
J Exp Med, 1997 Feb 03; 185(3). PMID: 9053445    Free PMC article.
Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine.
V Bronte, M W Carroll, +6 authors, N P Restifo.
Proc Natl Acad Sci U S A, 1997 Apr 01; 94(7). PMID: 9096367    Free PMC article.
Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100.
Y Zhai, J C Yang, +5 authors, S A Rosenberg.
J Immunother, 1997 Jan 01; 20(1). PMID: 9101410    Free PMC article.
Cancer vaccines based on the identification of genes encoding cancer regression antigens.
S A Rosenberg.
Immunol Today, 1997 Apr 01; 18(4). PMID: 9136454
Review.
The Th1/Th2 paradigm.
S Romagnani.
Immunol Today, 1997 Jun 01; 18(6). PMID: 9190109
Highly Cited. Review.
Tumor antigens recognized by T cells.
T Boon, P G Coulie, B Van den Eynde.
Immunol Today, 1997 Jun 01; 18(6). PMID: 9190110
Highly Cited. Review.
Requirement of CD4 T cells for skin graft rejection against thymus leukemia (TL) antigen and multiple epitopes on the TL molecule recognized by CD4 T cells.
K Tsuji, Y Obata, +2 authors, E Nakayama.
J Immunol, 1997 Jul 01; 159(1). PMID: 9200451
A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.
S Akkaraju, W Y Ho, +3 authors, C C Goodnow.
Immunity, 1997 Aug 01; 7(2). PMID: 9285410
Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism.
G J Christianson, W Brooks, +6 authors, D C Roopenian.
J Immunol, 1997 Nov 20; 159(10). PMID: 9366402
Compact, synthetic, vaccinia virus early/late promoter for protein expression.
S Chakrabarti, J R Sisler, B Moss.
Biotechniques, 1998 Jan 09; 23(6). PMID: 9421642
Highly Cited.
Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors.
F Ossendorp, E Mengedé, +2 authors, C J Melief.
J Exp Med, 1998 Mar 28; 187(5). PMID: 9480979    Free PMC article.
Highly Cited.
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma.
S A Rosenberg, J C Yang, +13 authors, D E White.
Nat Med, 1998 Mar 21; 4(3). PMID: 9500606    Free PMC article.
Highly Cited.
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell.
J P Ridge, F Di Rosa, P Matzinger.
Nature, 1998 Jun 12; 393(6684). PMID: 9624003
Highly Cited.
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.
S P Schoenberger, R E Toes, +2 authors, C J Melief.
Nature, 1998 Jun 12; 393(6684). PMID: 9624005
Highly Cited.
CD4+ T cells, but not CD8+ T cells, are required for the development of experimental autoimmune gastritis.
H D De Silva, I R Van Driel, +2 authors, P A Gleeson.
Immunology, 1998 Jun 26; 93(3). PMID: 9640252    Free PMC article.
gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand.
W W Overwijk, A Tsung, +8 authors, N P Restifo.
J Exp Med, 1998 Jul 22; 188(2). PMID: 9670040    Free PMC article.
Highly Cited.
CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice.
F Van de Keere, S Tonegawa.
J Exp Med, 1998 Nov 17; 188(10). PMID: 9815265    Free PMC article.
Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.
V Bronte, D B Chappell, +4 authors, N P Restifo.
J Immunol, 1999 May 07; 162(10). PMID: 10229805    Free PMC article.
Highly Cited.
Inducing autoimmune disease to treat cancer.
D M Pardoll.
Proc Natl Acad Sci U S A, 1999 May 13; 96(10). PMID: 10318881    Free PMC article.
Cancer therapy using a self-replicating RNA vaccine.
H Ying, T Z Zaks, +5 authors, N P Restifo.
Nat Med, 1999 Jul 08; 5(7). PMID: 10395329    Free PMC article.
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation.
A van Elsas, A A Hurwitz, J P Allison.
J Exp Med, 1999 Aug 03; 190(3). PMID: 10430624    Free PMC article.
Highly Cited.
Coupling and uncoupling of tumor immunity and autoimmunity.
W B Bowne, R Srinivasan, +5 authors, A N Houghton.
J Exp Med, 1999 Dec 10; 190(11). PMID: 10587362    Free PMC article.
Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen.
D R Surman, M E Dudley, W W Overwijk, N P Restifo.
J Immunol, 2000 Jan 07; 164(2). PMID: 10623795    Free PMC article.
Genetic vaccination with "self" tyrosinase-related protein 2 causes melanoma eradication but not vitiligo.
V Bronte, E Apolloni, +5 authors, P Zanovello.
Cancer Res, 2000 Feb 10; 60(2). PMID: 10667570    Free PMC article.
Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease.
B Ludewig, A F Ochsenbein, +3 authors, R M Zinkernagel.
J Exp Med, 2000 Mar 08; 191(5). PMID: 10704461    Free PMC article.
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
T A Colella, T N Bullock, +6 authors, V H Engelhard.
J Exp Med, 2000 Apr 05; 191(7). PMID: 10748239    Free PMC article.
Cytotoxic T cell immunity against telomerase reverse transcriptase in humans.
B Minev, J Hipp, +3 authors, M Zanetti.
Proc Natl Acad Sci U S A, 2000 Apr 12; 97(9). PMID: 10759561    Free PMC article.
An autologous oral DNA vaccine protects against murine melanoma.
R Xiang, H N Lode, +7 authors, R A Reisfeld.
Proc Natl Acad Sci U S A, 2000 Apr 26; 97(10). PMID: 10779556    Free PMC article.
Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction.
H N Lode, R Xiang, +4 authors, R A Reisfeld.
J Clin Invest, 2000 Jun 07; 105(11). PMID: 10841521    Free PMC article.
Identification of CD4+ T cell epitopes from NY-ESO-1 presented by HLA-DR molecules.
G Zeng, C E Touloukian, +3 authors, R F Wang.
J Immunol, 2000 Jul 06; 165(2). PMID: 10878395    Free PMC article.
Recombinant yellow fever viruses are effective therapeutic vaccines for treatment of murine experimental solid tumors and pulmonary metastases.
A McAllister, A E Arbetman, +2 authors, R Andino.
J Virol, 2000 Sep 12; 74(19). PMID: 10982366    Free PMC article.
Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity.
N P Restifo.
Curr Opin Immunol, 2000 Sep 28; 12(5). PMID: 11007365    Free PMC article.
Review.
Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo.
C Yee, J A Thompson, +7 authors, P D Greenberg.
J Exp Med, 2000 Dec 06; 192(11). PMID: 11104805    Free PMC article.
Vaccination for melanoma.
L W Thompson, L Brinckerhoff, C L Slingluff.
Curr Oncol Rep, 2000 Dec 21; 2(4). PMID: 11122856
Review.
Targeting pediatric malignancies for T cell-mediated immune responses.
C L Mackall, L J Helman.
Curr Oncol Rep, 2000 Dec 21; 2(6). PMID: 11122890
Review.
CD4(+) T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: association with NY-ESO-1 antibody production.
G Zeng, X Wang, +2 authors, R F Wang.
Proc Natl Acad Sci U S A, 2001 Mar 22; 98(7). PMID: 11259659    Free PMC article.
Creating therapeutic cancer vaccines: notes from the battlefield.
W W Overwijk, N P Restifo.
Trends Immunol, 2001 Apr 05; 22(1). PMID: 11286676    Free PMC article.
Autologous and allogeneic high-dose therapy for melanoma.
K A Margolin.
Curr Oncol Rep, 2001 Jun 08; 3(4). PMID: 11389819
Review.
Hierarchy, tolerance, and dominance in the antitumor T-cell response.
N P Restifo.
J Immunother, 2001 Jun 08; 24(3). PMID: 11394495    Free PMC article.
Review.
Autoimmunity and the immunotherapy of cancer: targeting the "self" to destroy the "other".
W W Overwijk, N P Restifo.
Crit Rev Immunol, 2001 Jun 09; 20(6). PMID: 11396680    Free PMC article.
Review.
Progress in cancer vaccines by enhanced self-presentation.
S R Riddell.
Proc Natl Acad Sci U S A, 2001 Aug 02; 98(16). PMID: 11481463    Free PMC article.
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy.
A van Elsas, R P Sutmuller, +8 authors, J P Allison.
J Exp Med, 2001 Aug 22; 194(4). PMID: 11514604    Free PMC article.
CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination.
R M Kedl, M Jordan, +3 authors, S Dow.
Proc Natl Acad Sci U S A, 2001 Aug 30; 98(19). PMID: 11526222    Free PMC article.
Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen.
Y Q Wei, M J Huang, +28 authors, W Zhang.
Proc Natl Acad Sci U S A, 2001 Sep 13; 98(20). PMID: 11553767    Free PMC article.
Mining the melanosome for tumor vaccine targets: P.polypeptide is a novel tumor-associated antigen.
C E Touloukian, W W Leitner, +2 authors, N P Restifo.
Cancer Res, 2001 Nov 24; 61(22). PMID: 11719435    Free PMC article.
Assumptions of the tumor 'escape' hypothesis.
Nicholas P Restifo, Paul A Antony, +4 authors, Christopher E Touloukian.
Semin Cancer Biol, 2002 Apr 03; 12(1). PMID: 11926416    Free PMC article.
Review.
Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?
Paul Andrew Antony, Nicholas P Restifo.
J Immunother, 2002 May 10; 25(3). PMID: 12000861    Free PMC article.
Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells.
Helen Y Wang, Tihui Fu, +6 authors, Rong-Fu Wang.
J Clin Invest, 2002 Jun 05; 109(11). PMID: 12045260    Free PMC article.
T cell homeostatic proliferation elicits effective antitumor autoimmunity.
Wolfgang Dummer, Andreas G Niethammer, +4 authors, Argyrios N Theofilopoulos.
J Clin Invest, 2002 Jul 18; 110(2). PMID: 12122110    Free PMC article.
Highly Cited.
Cancer vaccines: progress reveals new complexities.
Zhiya Yu, Nicholas P Restifo.
J Clin Invest, 2002 Aug 07; 110(3). PMID: 12163445    Free PMC article.
Review.
Regulation of tumour immunity by CD25+ T cells.
Awen Gallimore, Shimon Sakaguchi.
Immunology, 2002 Sep 13; 107(1). PMID: 12225357    Free PMC article.
Review.
Expression of a "self-"antigen by human tumor cells enhances tumor antigen-specific CD4(+) T-cell function.
Christopher E Touloukian, Wolfgang W Leitner, +6 authors, Nicholas P Restifo.
Cancer Res, 2002 Sep 18; 62(18). PMID: 12234976    Free PMC article.
Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanoma.
Paul F Robbins, Mona El-Gamil, +3 authors, Steven A Rosenberg.
J Immunol, 2002 Nov 08; 169(10). PMID: 12421991    Free PMC article.
Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways.
Wolfgang W Leitner, Leroy N Hwang, +6 authors, Nicholas P Restifo.
Nat Med, 2002 Dec 24; 9(1). PMID: 12496961    Free PMC article.
Normal tissue depresses while tumor tissue enhances human T cell responses in vivo to a novel self/tumor melanoma antigen, OA1.
Christopher E Touloukian, Wolfgang W Leitner, +6 authors, Nicholas P Restifo.
J Immunol, 2003 Jan 23; 170(3). PMID: 12538723    Free PMC article.
Melanosomes and MHC class II antigen-processing compartments: a tinted view of intracellular trafficking and immunity.
Michael S Marks, Alexander C Theos, Graça Raposo.
Immunol Res, 2003 Jul 15; 27(2-3). PMID: 12857985
Review.
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.
Willem W Overwijk, Marc R Theoret, +15 authors, Nicholas P Restifo.
J Exp Med, 2003 Aug 20; 198(4). PMID: 12925674    Free PMC article.
Highly Cited.
Adoptive-cell-transfer therapy for the treatment of patients with cancer.
Mark E Dudley, Steven A Rosenberg.
Nat Rev Cancer, 2003 Sep 03; 3(9). PMID: 12951585    Free PMC article.
Highly Cited. Review.
Tissue-selective therapy of cancer.
M V Blagosklonny.
Br J Cancer, 2003 Oct 02; 89(7). PMID: 14520435    Free PMC article.
Review.
High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy.
David-Alexandre Gross, Stéphanie Graff-Dubois, +12 authors, Kostas Kosmatopoulos.
J Clin Invest, 2004 Feb 03; 113(3). PMID: 14755339    Free PMC article.
Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein.
Annika Vogt, Pao-Tien Chuang, +6 authors, Ervin H Epstein.
J Exp Med, 2004 Mar 17; 199(6). PMID: 15024045    Free PMC article.
Apoptosis is essential for the increased efficacy of alphaviral replicase-based DNA vaccines.
Wolfgang W Leitner, Leroy N Hwang, +3 authors, Nicholas P Restifo.
Vaccine, 2004 Apr 06; 22(11-12). PMID: 15063579    Free PMC article.
Desensitization of T lymphocyte function by CXCR3 ligands in human hepatocellular carcinoma.
Yu-Qing Liu, Ronnie-T Poon, +3 authors, Sheung-Tat Fan.
World J Gastroenterol, 2005 Jan 06; 11(2). PMID: 15633209    Free PMC article.
Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.
Christopher A Klebanoff, Hung T Khong, +2 authors, Nicholas P Restifo.
Trends Immunol, 2005 Jan 26; 26(2). PMID: 15668127    Free PMC article.
Highly Cited. Review.
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Paul A Antony, Ciriaco A Piccirillo, +9 authors, Nicholas P Restifo.
J Immunol, 2005 Feb 25; 174(5). PMID: 15728465    Free PMC article.
Highly Cited.
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma.
Mark E Dudley, John R Wunderlich, +18 authors, Steven A Rosenberg.
J Clin Oncol, 2005 Apr 01; 23(10). PMID: 15800326    Free PMC article.
Highly Cited.
Combining cytotoxic and immune-mediated gene therapy to treat brain tumors.
James F Curtin, Gwendalyn D King, +4 authors, Maria G Castro.
Curr Top Med Chem, 2005 Oct 27; 5(12). PMID: 16248789    Free PMC article.
Review.
Anti-HER-2 DNA vaccine protects Syrian hamsters against squamous cell carcinomas.
G N Berta, B Mognetti, +5 authors, F Cavallo.
Br J Cancer, 2005 Nov 03; 93(11). PMID: 16265350    Free PMC article.
Fighting cancer with oncolytic viruses.
Yuti Chernajovsky, Lorna Layward, Nicholas Lemoine.
BMJ, 2006 Jan 21; 332(7534). PMID: 16424499    Free PMC article.
Review.
Optimization of a self antigen for presentation of multiple epitopes in cancer immunity.
José A Guevara-Patiño, Manuel E Engelhorn, +7 authors, Alan N Houghton.
J Clin Invest, 2006 Apr 15; 116(5). PMID: 16614758    Free PMC article.
Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes.
Yangbing Zhao, Zhili Zheng, +2 authors, Richard A Morgan.
J Immunother, 2006 Jun 27; 29(4). PMID: 16799335    Free PMC article.
A2A adenosine receptor protects tumors from antitumor T cells.
Akio Ohta, Elieser Gorelik, +12 authors, Michail Sitkovsky.
Proc Natl Acad Sci U S A, 2006 Aug 19; 103(35). PMID: 16916931    Free PMC article.
Highly Cited.
A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell function.
Gavin M Bendle, Shao-An Xue, Angelika Holler, Hans J Stauss.
PLoS One, 2007 Apr 05; 2(4). PMID: 17406677    Free PMC article.
Induction of antitumor acquired immunity by baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mice.
Masayuki Kitajima, Hiroshi Takaku.
Clin Vaccine Immunol, 2007 Dec 07; 15(2). PMID: 18057182    Free PMC article.
Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming.
Djordje Atanackovic, Nasser K Altorki, +7 authors, Sacha Gnjatic.
Proc Natl Acad Sci U S A, 2008 Jan 25; 105(5). PMID: 18216244    Free PMC article.
Generation and characterization of transgenic mice expressing a T-cell receptor specific for the tumour-associated antigen MDM2.
Shao-An Xue, Gavin M Bendle, Angelika Holler, Hans J Stauss.
Immunology, 2008 Jan 26; 124(3). PMID: 18217949    Free PMC article.
Mechanisms of immunization against cancer using chimeric antigens.
Manuel E Engelhorn, José A Guevara-Patiño, +7 authors, Jedd D Wolchok.
Mol Ther, 2008 Feb 28; 16(4). PMID: 18301399    Free PMC article.
HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
Cecele J Denman, James McCracken, +4 authors, I Caroline Le Poole.
J Invest Dermatol, 2008 Mar 14; 128(8). PMID: 18337834    Free PMC article.
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Pawel Muranski, Andrea Boni, +14 authors, Nicholas P Restifo.
Blood, 2008 Mar 21; 112(2). PMID: 18354038    Free PMC article.
Highly Cited.
Strategies and challenges in eliciting immunity to melanoma.
Andrew R Ferguson, Lisa A Nichols, +5 authors, Victor H Engelhard.
Immunol Rev, 2008 Mar 28; 222. PMID: 18363993    Free PMC article.
From "Hellstrom Paradox" to anti-adenosinergic cancer immunotherapy.
Dmitriy Lukashev, Michail Sitkovsky, Akio Ohta.
Purinergic Signal, 2008 Apr 12; 3(1-2). PMID: 18404426    Free PMC article.
B16 as a mouse model for human melanoma.
W W Overwijk, N P Restifo.
Curr Protoc Immunol, 2008 Apr 25; Chapter 20. PMID: 18432774    Free PMC article.
Highly Cited.
Anti-tumor immunity elicited by adenovirus encoding AdhTrp2 or AdmTrp2 without vitiligo.
Hongju Liu, Xianzhi Xiong, +3 authors, Yu Hu.
J Huazhong Univ Sci Technolog Med Sci, 2008 May 16; 28(2). PMID: 18480980
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.
Douglas C Palmer, Chi-Chao Chan, +11 authors, Nicholas P Restifo.
Proc Natl Acad Sci U S A, 2008 Jun 05; 105(23). PMID: 18523011    Free PMC article.
High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.
Andrew G Brandmaier, Wolfgang W Leitner, +3 authors, Christopher E Touloukian.
J Immunother, 2009 Jun 30; 32(7). PMID: 19561540    Free PMC article.
Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer.
Maurizio Chiriva-Internati, Yuefei Yu, +5 authors, W Martin Kast.
PLoS One, 2010 May 21; 5(5). PMID: 20485677    Free PMC article.
CD4+ and CD8+ T cells can act separately in tumour rejection after immunization with murine pneumotropic virus chimeric Her2/neu virus-like particles.
Kalle Andreasson, Mathilda Eriksson, +2 authors, Tina Dalianis.
PLoS One, 2010 Jul 27; 5(7). PMID: 20657846    Free PMC article.
GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1.
Matthew P Rausch, Kari R Irvine, +3 authors, K Taraszka Hastings.
J Immunol, 2010 Jul 30; 185(5). PMID: 20668223    Free PMC article.
Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.
Akshata Udyavar, Terrence L Geiger.
Arch Immunol Ther Exp (Warsz), 2010 Aug 04; 58(5). PMID: 20680493    Free PMC article.
Review.
Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.
Sung P Ha, Nicholas D Klemen, +8 authors, Christopher E Touloukian.
J Clin Invest, 2010 Nov 19; 120(12). PMID: 21084750    Free PMC article.
DNA vaccination: using the patient's immune system to overcome cancer.
Georg Eschenburg, Alexander Stermann, +2 authors, Holger N Lode.
Clin Dev Immunol, 2011 Jan 05; 2010. PMID: 21197271    Free PMC article.
Review.
GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.
Matthew P Rausch, K Taraszka Hastings.
J Invest Dermatol, 2011 Aug 13; 132(1). PMID: 21833020    Free PMC article.
Clinical Efficacy of TroVax in the Treatment of Progressive Castration-resistant Prostate Cancer.
Robert J Amato, Mika Stepankiw.
Clin Med Insights Oncol, 2012 Jan 19; 6. PMID: 22253556    Free PMC article.
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
Adam J Adler, Anthony T Vella.
Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891    Free PMC article.
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.
Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536636    Free PMC article.
Highly Cited.
Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.
Dhanalakshmi Chinnasamy, Eric Tran, +3 authors, Steven A Rosenberg.
Cancer Res, 2013 May 02; 73(11). PMID: 23633494    Free PMC article.
Identification of Pre- and Post-Treatment Markers, Clinical, and Laboratory Parameters Associated with Outcome in Renal Cancer Patients Treated with MVA-5T4.
Rabih Said, Robert J Amato.
Front Oncol, 2013 Jul 23; 3. PMID: 23875174    Free PMC article.
How numbers, nature, and immune status of foxp3(+) regulatory T-cells shape the early immunological events in tumor development.
Guillaume Darrasse-Jèze, Katrina Podsypanina.
Front Immunol, 2013 Oct 18; 4. PMID: 24133490    Free PMC article.
Review.
Innate immune mechanisms in vitiligo: danger from within.
Jillian M Richmond, Michael L Frisoli, John E Harris.
Curr Opin Immunol, 2013 Nov 19; 25(6). PMID: 24238922    Free PMC article.
Review.
Modulation of bone morphogenic protein signaling in T-cells for cancer immunotherapy.
Michal Kuczma, Agnieszka Kurczewska, Piotr Kraj.
J Immunotoxicol, 2013 Dec 20; 11(4). PMID: 24350726    Free PMC article.
Global Inhibition of DC Priming Capacity in the Spleen of Self-Antigen Vaccinated Mice Requires IL-10.
Douglas M Marvel, Olivera J Finn.
Front Immunol, 2014 Mar 07; 5. PMID: 24596571    Free PMC article.
Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy.
David Escors.
New J Sci, 2014 Mar 19; 2014. PMID: 24634791    Free PMC article.
Mouse model for pre-clinical study of human cancer immunotherapy.
Zhiya Ya, Yared Hailemichael, Willem Overwijk, Nicholas P Restifo.
Curr Protoc Immunol, 2015 Feb 03; 108. PMID: 25640991    Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Review.
Optimization of Peptide Vaccines to Induce Robust Antitumor CD4 T-cell Responses.
Takumi Kumai, Sujin Lee, +4 authors, Esteban Celis.
Cancer Immunol Res, 2016 Dec 13; 5(1). PMID: 27941004    Free PMC article.
Combination immunotherapy: a road map.
Patrick A Ott, F Stephen Hodi, +2 authors, Jedd D Wolchok.
J Immunother Cancer, 2017 Feb 28; 5. PMID: 28239469    Free PMC article.
Highly Cited. Review.
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain.
Manisha Singh, Christina Vianden, +15 authors, Willem W Overwijk.
Nat Commun, 2017 Nov 14; 8(1). PMID: 29129918    Free PMC article.
A modified HLA-A*0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses.
Weihong Sun, Junyi Shi, +8 authors, Nan Li.
Cell Mol Immunol, 2018 Jan 30; 15(8). PMID: 29375131    Free PMC article.
Post-operative unadjuvanted therapeutic xenovaccination with chicken whole embryo vaccine suppresses distant micrometastases and prolongs survival in a murine Lewis lung carcinoma model.
Jan Aleksander Kraśko, Karolina Žilionytė, +13 authors, Vita Pašukonienė.
Oncol Lett, 2018 Mar 20; 15(4). PMID: 29552144    Free PMC article.
Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens.
Christine E Nelson, Emily A Thompson, +6 authors, Vaiva Vezys.
Cell Rep, 2019 Sep 19; 28(12). PMID: 31533033    Free PMC article.
Identification of Ixodid Tick-Specific Aquaporin-1 Potential Anti-tick Vaccine Epitopes: An in-silico Analysis.
Christian Ndekezi, Joseph Nkamwesiga, +5 authors, Dennis Muhanguzi.
Front Bioeng Biotechnol, 2019 Oct 16; 7. PMID: 31612130    Free PMC article.
Adjuvant effect of HER-2/neu-specific adenoviral vector stimulating CD8⁺ T and natural killer cell responses on anti-HER-2/neu antibody therapy for well-established breast tumors in HER-2/neu transgenic mice.
Y Chen, Y Xie, +4 authors, J Xiang.
Cancer Gene Ther, 2011 May 14; 18(7). PMID: 21566669    Free PMC article.
Tumor-specific CD4+ melanoma tumor-infiltrating lymphocytes.
Kevin M Friedman, Peter A Prieto, +5 authors, Mark E Dudley.
J Immunother, 2012 May 12; 35(5). PMID: 22576345    Free PMC article.
Default polyfunctional T helper 1 response to ample signal 1 alone.
Luca Danelli, Georgina Cornish, Julia Merkenschlager, George Kassiotis.
Cell Mol Immunol, 2020 Apr 22; 18(7). PMID: 32313208    Free PMC article.
Beneficial autoimmunity improves cancer prognosis.
Laurence Zitvogel, Claude Perreault, Olivera J Finn, Guido Kroemer.
Nat Rev Clin Oncol, 2021 May 13; 18(9). PMID: 33976418
Review.