Journal Article
. 1999 May;17(5).
doi: 10.1200/JCO.1999.17.5.1474.

Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer

J M Harvey 1 G M Clark  C K Osborne  D C Allred  
Affiliations
  • PMID: 10334533
  •     590 citations

Abstract

Purpose: Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the traditional ligand-binding assay (LBA). The purpose of this study was to evaluate the ability of ER status determination by IHC, compared with LBA, to predict clinical outcome-especially response to adjuvant endocrine therapy-in a large number of patients with long-term clinical follow-up.

Patients And Methods: ER status was evaluated in 1,982 primary breast cancers by IHC on formalin-fixed paraffin-embedded tissue sections, using antibody 6F11 and standard methodology. Slides were scored on a scale representing the estimated proportion and intensity of positive-staining tumor cells (range, 0 to 8). Results were compared with ER values obtained by the LBA in the same tumors and to clinical outcome.

Results: An IHC score of greater than 2 (corresponding to as few as 1% to 10% weakly positive cells) was used to define ER positivity on the basis of a univariate cut-point analysis of all possible scores and disease-free survival (DFS) in patients receiving any adjuvant endocrine therapy. Using this definition, 71% of all tumors were determined to be ER-positive by IHC, and the level of agreement with the LBA was 86%. In multivariate analyses of patients receiving adjuvant endocrine therapy alone, ER status determined by IHC was better than that determined by the LBA at predicting improved DFS (hazard ratios/P = 0.474/.0008 and 0.707/.3214, respectively) and equivalent at predicting overall survival (0.379/.0001 and 0.381/.0003, respectively).

Conclusion: IHC is superior to the LBA for assessing ER status in primary breast cancer because it is easier, safer, and less expensive, and has an equivalent or better ability to predict response to adjuvant endocrine therapy.

Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer.
T A Järvinen, M Pelto-Huikko, K Holli, J Isola.
Am J Pathol, 2000 Jan 07; 156(1). PMID: 10623650    Free PMC article.
Is there a growing role for endocrine therapy in the treatment of breast cancer?
P E Lønning.
Drugs, 2000 Aug 10; 60(1). PMID: 10929927
Review.
Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: correlation with patient age, assay sensitivity, threshold value, and mammographic screening.
A Rhodes, B Jasani, +2 authors, K D Miller.
J Clin Pathol, 2000 Oct 21; 53(9). PMID: 11041059    Free PMC article.
Molecular markers for predicting response to tamoxifen in breast cancer patients.
D R Ciocca, R Elledge.
Endocrine, 2000 Oct 29; 13(1). PMID: 11051041
Review.
Progesterone receptor A and B isoforms in the human breast and its disorders.
N Ariga, T Suzuki, +4 authors, H Sasano.
Jpn J Cancer Res, 2001 Mar 27; 92(3). PMID: 11267940    Free PMC article.
Immunohistochemical detection of ERbeta in breast cancer: towards more detailed receptor profiling?
G P Skliris, P J Carder, M R Lansdown, V Speirs.
Br J Cancer, 2001 Apr 20; 84(8). PMID: 11308260    Free PMC article.
Hypoxia reduces hormone responsiveness of human breast cancer cells.
J Kurebayashi, T Otsuki, T Moriya, H Sonoo.
Jpn J Cancer Res, 2001 Oct 26; 92(10). PMID: 11676860    Free PMC article.
Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years.
Attiqa N Mirza, Nadeem Q Mirza, Georges Vlastos, S Eva Singletary.
Ann Surg, 2001 Dec 26; 235(1). PMID: 11753038    Free PMC article.
Review.
The role of estrogen receptors in breast cancer metastasis.
S A Fuqua.
J Mammary Gland Biol Neoplasia, 2002 May 16; 6(4). PMID: 12013530
Review.
Duration of adjuvant chemotherapy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF.
M Colleoni, H J Litman, +18 authors, German Breast Cancer Study Group.
Br J Cancer, 2002 Jun 28; 86(11). PMID: 12087454    Free PMC article.
Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters.
Suzanne A W Fuqua, Rachel Schiff, +5 authors, D Craig Allred.
Cancer Res, 2003 May 17; 63(10). PMID: 12750263    Free PMC article.
Clinical pharmacokinetics of aromatase inhibitors and inactivators.
Per Lønning.
Clin Pharmacokinet, 2003 Jul 08; 42(7). PMID: 12844324
Review.
The role of biological markers as predictors of response to preoperative chemotherapy in large primary breast cancer.
Veronique F Cocquyt, Vera R Schelfhout, +5 authors, Simon J P Van Belle.
Med Oncol, 2003 Sep 30; 20(3). PMID: 14514971
Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast.
Zhenhuan Zhang, Hiroko Yamashita, +6 authors, Hirotaka Iwase.
Breast Cancer Res, 2003 Oct 29; 5(6). PMID: 14580261    Free PMC article.
Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer.
Hiroko Yamashita, Mariko Nishio, +4 authors, Hirotaka Iwase.
Breast Cancer Res, 2003 Dec 19; 6(1). PMID: 14680497    Free PMC article.
The favourable prognostic value of oestrogen receptor beta immunohistochemical expression in breast cancer.
L Nakopoulou, A C Lazaris, +4 authors, A Keramopoulos.
J Clin Pathol, 2004 Apr 29; 57(5). PMID: 15113861    Free PMC article.
Consistency of staining and reporting of oestrogen receptor immunocytochemistry within the European Union--an inter-laboratory study.
C A Wells, J P Sloane, +37 authors, European Working Group for Breast Screening Pathology.
Virchows Arch, 2004 Jun 29; 445(2). PMID: 15221370
Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1.
F J Fleming, E Myers, +5 authors, L S Young.
J Clin Pathol, 2004 Sep 29; 57(10). PMID: 15452162    Free PMC article.
Inverse relationship between ER-beta and SRC-1 predicts outcome in endocrine-resistant breast cancer.
E Myers, F J Fleming, +5 authors, L S Young.
Br J Cancer, 2004 Oct 13; 91(9). PMID: 15477868    Free PMC article.
The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer.
D Craig Allred, Powel Brown, Daniel Medina.
Breast Cancer Res, 2004 Nov 13; 6(6). PMID: 15535853    Free PMC article.
Review.
Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer.
A E Ring, I E Smith, +2 authors, S R Lakhani.
Br J Cancer, 2004 Nov 24; 91(12). PMID: 15558072    Free PMC article.
Evaluation of ER, PgR, HER-2 and Ki-67 as predictors of response to neoadjuvant anthracycline chemotherapy for operable breast cancer.
R J Burcombe, A Makris, +7 authors, G D Wilson.
Br J Cancer, 2004 Dec 22; 92(1). PMID: 15611798    Free PMC article.
Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer.
Christina H Yeon, Mark D Pegram.
Invest New Drugs, 2005 Sep 01; 23(5). PMID: 16133791
Review.
Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ.
Ruria Namba, Lawrence J T Young, +8 authors, Jeffrey P Gregg.
Breast Cancer Res, 2005 Nov 11; 7(6). PMID: 16280035    Free PMC article.
Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer.
Sangjun Lee, Syed K Mohsin, +3 authors, D Craig Allred.
Breast Cancer Res, 2006 Jan 19; 8(1). PMID: 16417654    Free PMC article.
Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer.
M Burkhardt, E Mayordomo, +8 authors, G Kristiansen.
J Clin Pathol, 2006 Feb 18; 59(4). PMID: 16484444    Free PMC article.
Basal-like breast carcinomas: clinical outcome and response to chemotherapy.
S Banerjee, J S Reis-Filho, +4 authors, I E Smith.
J Clin Pathol, 2006 Mar 25; 59(7). PMID: 16556664    Free PMC article.
Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells.
Gui Su, Kristy Meyer, +3 authors, Andreas Friedl.
Am J Pathol, 2006 May 26; 168(6). PMID: 16723715    Free PMC article.
The reliability of assessment of oestrogen receptor expression on needle core biopsy specimens of invasive carcinomas of the breast.
Zsolt Hodi, Jayeta Chakrabarti, +5 authors, Ian O Ellis.
J Clin Pathol, 2006 May 30; 60(3). PMID: 16731591    Free PMC article.
Review.
A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients.
Laurel A Habel, Steven Shak, +12 authors, Charles P Quesenberry.
Breast Cancer Res, 2006 Jun 02; 8(3). PMID: 16737553    Free PMC article.
Highly Cited.
Semi-quantitative scoring of potentially predictive markers for endocrine treatment of breast cancer: a comparison between whole sections and tissue microarrays.
Katrine L Henriksen, Birgitte B Rasmussen, +3 authors, Henning T Mouridsen.
J Clin Pathol, 2006 Jun 16; 60(4). PMID: 16775123    Free PMC article.
Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours.
G P Skliris, E Leygue, +2 authors, L C Murphy.
Br J Cancer, 2006 Aug 02; 95(5). PMID: 16880783    Free PMC article.
A positive role for PEA3 in HER2-mediated breast tumour progression.
E Myers, A D K Hill, +3 authors, L S Young.
Br J Cancer, 2006 Oct 25; 95(10). PMID: 17060941    Free PMC article.
Skeletal complications of breast cancer therapies.
Angela Hirbe, Elizabeth A Morgan, Ozge Uluçkan, Katherine Weilbaecher.
Clin Cancer Res, 2006 Oct 26; 12(20 Pt 2). PMID: 17062720    Free PMC article.
Review.
Cellular and molecular regulation of the primate endometrium: a perspective.
William C Okulicz.
Reprod Biol Endocrinol, 2006 Nov 23; 4 Suppl 1. PMID: 17118167    Free PMC article.
Review.
Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients.
Lisa K Dunnwald, Mary Anne Rossing, Christopher I Li.
Breast Cancer Res, 2007 Jan 24; 9(1). PMID: 17239243    Free PMC article.
Highly Cited.
Survivin is an independent predictor of short-term survival in poor prognostic breast cancer patients.
A R Hinnis, J C A Luckett, R A Walker.
Br J Cancer, 2007 Feb 08; 96(4). PMID: 17285125    Free PMC article.
Association between the estrogen receptor alpha A908G mutation and outcomes in invasive breast cancer.
Matthew H Herynk, Irma Parra, +4 authors, Suzanne A W Fuqua.
Clin Cancer Res, 2007 Jun 05; 13(11). PMID: 17545528    Free PMC article.
Molecular response to aromatase inhibitor treatment in primary breast cancer.
Alan Mackay, Ander Urruticoechea, +10 authors, Mitch Dowsett.
Breast Cancer Res, 2007 Jun 09; 9(3). PMID: 17555561    Free PMC article.
Association of oestrogen receptor beta 2 (ER beta 2/ER beta cx) with outcome of adjuvant endocrine treatment for primary breast cancer--a retrospective study.
Raman Vinayagam, D Ross Sibson, +2 authors, Michael Pa Davies.
BMC Cancer, 2007 Jul 21; 7. PMID: 17640362    Free PMC article.
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers.
Christina Yau, Vita Fedele, +11 authors, Christopher C Benz.
Breast Cancer Res, 2007 Sep 14; 9(5). PMID: 17850661    Free PMC article.
Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer.
E Fiore, E Giustarini, +5 authors, C Giani.
J Endocrinol Invest, 2007 Nov 13; 30(9). PMID: 17993764
VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival.
Jian Fu, Kathryn Fong, +9 authors, Andres J Klein-Szanto.
PLoS One, 2008 Feb 28; 3(2). PMID: 18301774    Free PMC article.
Lymph vascular invasion in invasive mammary carcinomas identified by the endothelial lymphatic marker D2-40 is associated with other indicators of poor prognosis.
Vanessa F Z Marinho, Konradin Metze, +2 authors, Helenice Gobbi.
BMC Cancer, 2008 Mar 01; 8. PMID: 18307818    Free PMC article.
Minireview: nuclear receptors and breast cancer.
Suzanne D Conzen.
Mol Endocrinol, 2008 Apr 18; 22(10). PMID: 18417735    Free PMC article.
Review.
Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival.
Alexander M Spence, Mark Muzi, +10 authors, Kenneth A Krohn.
Clin Cancer Res, 2008 May 03; 14(9). PMID: 18451225    Free PMC article.
Highly Cited.
[Interlaboratory trials for quality assurance of breast cancer biomarkers in Germany].
C A Krusche, R von Wasielewski, +2 authors, H H Kreipe.
Pathologe, 2008 May 28; 29(4). PMID: 18504581
Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program.
Patricia S Steeg.
Clin Cancer Res, 2008 Jun 19; 14(12). PMID: 18559575    Free PMC article.
Immunohistochemical profiles of brain metastases from breast cancer.
Kan Yonemori, Koji Tsuta, +9 authors, Yasuhiro Fujiwara.
J Neurooncol, 2008 Jul 24; 90(2). PMID: 18648908
Changes in subcellular localisation of MI-ER1 alpha, a novel oestrogen receptor-alpha interacting protein, is associated with breast cancer progression.
P L McCarthy, F C Mercer, +3 authors, L L Gillespie.
Br J Cancer, 2008 Jul 31; 99(4). PMID: 18665173    Free PMC article.
Prognostic utility of the 21-gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features.
Lori J Goldstein, Robert Gray, +12 authors, Joseph A Sparano.
J Clin Oncol, 2008 Aug 06; 26(25). PMID: 18678838    Free PMC article.
Highly Cited.
Expression of estrogen receptor alpha and beta in breast cancers of pre- and post-menopausal women.
Blanca Murillo-Ortiz, Elva Pérez-Luque, +3 authors, Luis Benítez-Bribiesca.
Pathol Oncol Res, 2008 Aug 30; 14(4). PMID: 18752050
Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer.
Kazuharu Kai, Zhenhuan Zhang, +3 authors, Hirotaka Iwase.
BMC Cancer, 2008 Sep 18; 8. PMID: 18796146    Free PMC article.
Luminal B breast tumors are not HER2 positive.
Rohit Bhargava, David J Dabbs.
Breast Cancer Res, 2008 Oct 04; 10(5). PMID: 18831725    Free PMC article.
Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically.
Andrea Proctor Subhawong, Ty Subhawong, +5 authors, Pedram Argani.
Am J Surg Pathol, 2008 Oct 22; 33(2). PMID: 18936692    Free PMC article.
Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers.
Tatsuya Toyama, Hiroko Yamashita, +6 authors, Yoshitaka Fujii.
BMC Cancer, 2008 Oct 28; 8. PMID: 18950515    Free PMC article.
Is adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93.
Olivia Pagani, Shari Gelber, +14 authors, International Breast Cancer Study Group.
Breast Cancer Res Treat, 2008 Oct 28; 116(3). PMID: 18953651    Free PMC article.
Heat shock protein90 in lobular neoplasia of the breast.
Flora Zagouri, Afrodite Nonni, +5 authors, George C Zografos.
BMC Cancer, 2008 Oct 30; 8. PMID: 18957107    Free PMC article.
Proficiency testing of immunohistochemical biomarker assays in breast cancer.
Reinhard von Wasielewski, Svenja Hasselmann, +2 authors, Hans Kreipe.
Virchows Arch, 2008 Oct 30; 453(6). PMID: 18958494
Markers of endocrine sensitivity.
Daniel F Hayes.
Breast Cancer Res, 2009 Jan 16; 10 Suppl 4. PMID: 19128431    Free PMC article.
The utility of conventional and molecular pathology in managing breast cancer.
D Craig Allred.
Breast Cancer Res, 2009 Jan 16; 10 Suppl 4. PMID: 19128442    Free PMC article.
Protease-activated receptor-1 is upregulated in reactive stroma of primary prostate cancer and bone metastasis.
Xiaotun Zhang, Wenbin Wang, +2 authors, Thomas K Takayama.
Prostate, 2009 Jan 27; 69(7). PMID: 19170048    Free PMC article.
A single-tube quantitative assay for mRNA levels of hormonal and growth factor receptors in breast cancer specimens.
Ayuko A Iverson, Cheryl Gillett, +12 authors, Sheng-Yung P Chang.
J Mol Diagn, 2009 Feb 20; 11(2). PMID: 19225135    Free PMC article.
Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer.
M Loddo, S R Kingsbury, +10 authors, G H Williams.
Br J Cancer, 2009 Feb 26; 100(6). PMID: 19240714    Free PMC article.
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
Zhiyong Guo, Xi Yang, +11 authors, Yun Qiu.
Cancer Res, 2009 Feb 27; 69(6). PMID: 19244107    Free PMC article.
Highly Cited.
ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers.
Joeli A Brinkman, Dorraya El-Ashry.
J Mammary Gland Biol Neoplasia, 2009 Mar 06; 14(1). PMID: 19263197
Review.
Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression.
So Hee Kim, Fred R Miller, +2 authors, Raymond F Novak.
Int J Cancer, 2009 Mar 18; 124(12). PMID: 19291795    Free PMC article.
Prevalence, morphologic features and proliferation indices of breast carcinoma molecular classes using immunohistochemical surrogate markers.
Rohit Bhargava, Joan Striebel, +4 authors, David J Dabbs.
Int J Clin Exp Pathol, 2009 Mar 19; 2(5). PMID: 19294003    Free PMC article.
Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
Kexin Xu, Hermela Shimelis, +13 authors, Yun Qiu.
Cancer Cell, 2009 Apr 07; 15(4). PMID: 19345326    Free PMC article.
Immunostaining with D2-40 improves evaluation of lymphovascular invasion, but may not predict sentinel lymph node status in early breast cancer.
Anna V Britto, André A Schenka, +4 authors, Laura S Ward.
BMC Cancer, 2009 Apr 10; 9. PMID: 19356249    Free PMC article.
Integrated functional, gene expression and genomic analysis for the identification of cancer targets.
Elizabeth Iorns, Christopher J Lord, +10 authors, Alan Ashworth.
PLoS One, 2009 Apr 10; 4(4). PMID: 19357772    Free PMC article.
Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the Nurses' Health Study.
Jonathan L Hecht, Joanne Kotsopoulos, Susan E Hankinson, Shelley S Tworoger.
Cancer Epidemiol Biomarkers Prev, 2009 Apr 23; 18(5). PMID: 19383883    Free PMC article.
Messina: a novel analysis tool to identify biologically relevant molecules in disease.
Mark Pinese, Christopher J Scarlett, +5 authors, Andrew V Biankin.
PLoS One, 2009 Apr 29; 4(4). PMID: 19399185    Free PMC article.
Prevalent cases in observational studies of cancer survival: do they bias hazard ratio estimates?
E M Azzato, D Greenberg, +4 authors, P D P Pharoah.
Br J Cancer, 2009 Apr 30; 100(11). PMID: 19401693    Free PMC article.
Postoperative endocrine therapy for invasive breast cancer.
Leisha A Emens, Nancy E Davidson.
Cancer Treat Res, 2009 Jul 14; 151. PMID: 19593511    Free PMC article.
Review.
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression.
Alicia M Viloria-Petit, Laurent David, +12 authors, Jeffrey L Wrana.
Proc Natl Acad Sci U S A, 2009 Aug 12; 106(33). PMID: 19667198    Free PMC article.
A robust automated measure of average antibody staining in immunohistochemistry images.
Kingshuk Roy Choudhury, Kevin J Yagle, +2 authors, Joseph G Rajendran.
J Histochem Cytochem, 2009 Aug 19; 58(2). PMID: 19687472    Free PMC article.
Biological determinants of endocrine resistance in breast cancer.
Elizabeth A Musgrove, Robert L Sutherland.
Nat Rev Cancer, 2009 Aug 25; 9(9). PMID: 19701242
Highly Cited. Review.
Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors.
M Hauglid Flågeng, L L Haugan Moi, +5 authors, G Mellgren.
Br J Cancer, 2009 Sep 17; 101(8). PMID: 19755984    Free PMC article.
Intra- and interobserver reproducibility of interpretation of immunohistochemical stains of prostate cancer.
Sara Jonmarker Jaraj, Philippe Camparo, +4 authors, Lars Egevad.
Virchows Arch, 2009 Sep 18; 455(4). PMID: 19760433
Retrospective analysis of 119 Chinese noninflammatory locally advanced breast cancer cases treated with intravenous combination of vinorelbine and epirubicin as a neoadjuvant chemotherapy: a median follow-up of 63.4 months.
Ou Huang, Canming Chen, +9 authors, Kunwei Shen.
BMC Cancer, 2009 Oct 23; 9. PMID: 19845944    Free PMC article.
Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer.
Ilenia Migliaccio, Meng-Fen Wu, +7 authors, Adrian V Lee.
Breast Cancer Res Treat, 2009 Nov 20; 123(3). PMID: 19924529    Free PMC article.
Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer.
Joseph A Sparano, Lori J Goldstein, +12 authors, Robert Gray.
Clin Cancer Res, 2009 Dec 10; 15(24). PMID: 19996222    Free PMC article.
Tailored targeted therapy for all: a realistic and worthwhile objective?
Per Eystein Lønning.
Breast Cancer Res, 2010 Jan 20; 11 Suppl 3. PMID: 20030882    Free PMC article.
Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy.
Ching-hung Lin, Huang-chun Lien, +7 authors, Chiun-sheng Huang.
J Zhejiang Univ Sci B, 2010 Jan 01; 11(1). PMID: 20043345    Free PMC article.
Comparative study of the immunohistochemical detection of hormone receptor status and HER-2 expression in primary and paired recurrent/metastatic lesions of patients with breast cancer.
Ebru Sari, Gulnur Guler, +3 authors, Yavuz Ozisik.
Med Oncol, 2010 Jan 26; 28(1). PMID: 20099049
Pathology re-review as an essential component of breast cancer management.
C G Kleer.
Curr Oncol, 2010 Feb 25; 17(1). PMID: 20179796    Free PMC article.
Breast cancer hormone receptor assay results of core needle biopsy and modified radical mastectomy specimens from the same patients.
Gemma B Uy, Adriano V Laudico, +5 authors, Richard R Love.
Clin Breast Cancer, 2010 Mar 20; 10(2). PMID: 20299318    Free PMC article.
Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival.
Elizabeth M Azzato, Jonathan Tyrer, +53 authors, Paul D P Pharoah.
J Natl Cancer Inst, 2010 Mar 24; 102(9). PMID: 20308648    Free PMC article.
Common germ-line polymorphism of C1QA and breast cancer survival.
E M Azzato, A J X Lee, +4 authors, A T Maia.
Br J Cancer, 2010 Mar 25; 102(8). PMID: 20332777    Free PMC article.
Role of neo-adjuvant hormonal therapy in the treatment of breast cancer: a review of clinical trials.
Catherine Abrial, Xavier Durando, +7 authors, F Penault-Llorca.
Int J Gen Med, 2009 Jan 01; 2. PMID: 20360896    Free PMC article.
American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +29 authors, Antonio C Wolff.
J Clin Oncol, 2010 Apr 21; 28(16). PMID: 20404251    Free PMC article.
Highly Cited. Systematic Review.
Molecular basis for therapy resistance.
Per E Lønning.
Mol Oncol, 2010 May 15; 4(3). PMID: 20466604    Free PMC article.
Review.
Are estrogen receptors alpha detectable in normal and abnormal thyroid tissue?
Michael Vaiman, Youlian Olevson, +3 authors, Alex Kessler.
Eur Arch Otorhinolaryngol, 2010 May 18; 267(11). PMID: 20473764
Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer.
Sherry X Yang, Joseph P Costantino, +7 authors, Sandra M Swain.
J Clin Oncol, 2010 May 19; 28(18). PMID: 20479407    Free PMC article.
Incorporating tumour pathology information into breast cancer risk prediction algorithms.
Nasim Mavaddat, Timothy R Rebbeck, +2 authors, Antonis C Antoniou.
Breast Cancer Res, 2010 May 21; 12(3). PMID: 20482762    Free PMC article.
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +29 authors, Antonio C Wolff.
Arch Pathol Lab Med, 2010 Jun 09; 134(6). PMID: 20524868    Free PMC article.
Highly Cited.
The transcription factor REST is lost in aggressive breast cancer.
Matthew P Wagoner, Kearney T W Gunsalus, +3 authors, Avtar Roopra.
PLoS Genet, 2010 Jun 16; 6(6). PMID: 20548947    Free PMC article.
Absence of the caveolin-1 P132L mutation in cancers of the breast and other organs.
Shinya Koike, Yasuhiro Kodera, +2 authors, Yasushi Yatabe.
J Mol Diagn, 2010 Jun 29; 12(5). PMID: 20581046    Free PMC article.
ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67.
Vilppu J Tuominen, Sanna Ruotoistenmäki, +2 authors, Jorma Isola.
Breast Cancer Res, 2010 Jul 29; 12(4). PMID: 20663194    Free PMC article.
Highly Cited.
Molecular morphological approach to the pathological study of development and advancement of human breast cancer.
Takuya Moriya, Naoki Kanomata, +9 authors, Hiroshi Sonoo.
Med Mol Morphol, 2010 Aug 05; 43(2). PMID: 20683691
Review.
Decreased Hsp90 expression in infiltrative lobular carcinoma: an immunohistochemical study.
Flora Zagouri, Theodoros Sergentanis, +8 authors, George Zografos.
BMC Cancer, 2010 Aug 10; 10. PMID: 20691061    Free PMC article.
Genomic index of sensitivity to endocrine therapy for breast cancer.
W Fraser Symmans, Christos Hatzis, +13 authors, Lajos Pusztai.
J Clin Oncol, 2010 Aug 11; 28(27). PMID: 20697068    Free PMC article.
Highly Cited.
The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines.
Kristina Subik, Jin-Feng Lee, +8 authors, Ping Tang.
Breast Cancer (Auckl), 2010 Aug 11; 4. PMID: 20697531    Free PMC article.
Highly Cited.
Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.
Sara Rodriguez-Acebes, Ian Proctor, +7 authors, Gareth H Williams.
Am J Pathol, 2010 Aug 21; 177(4). PMID: 20724597    Free PMC article.
Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis.
Melissa K Brunckhorst, Hui Wang, Rong Lu, Qin Yu.
Cancer Res, 2010 Sep 09; 70(18). PMID: 20823154    Free PMC article.
Adjuvant Endocrine Therapy in Premenopausal Patients.
Michael Gnant.
Breast Care (Basel), 2008 Jan 01; 3(5). PMID: 20824025    Free PMC article.
Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival.
Yoon-La Choi, Ensel Oh, +12 authors, Young Kee Shin.
BMC Cancer, 2010 Sep 24; 10. PMID: 20860845    Free PMC article.
Short-term anastrozole therapy reduces Ki-67 and progesterone receptor expression in invasive breast cancer: a prospective, placebo-controlled, double-blind trial.
Andre Mattar, Angela Flávia Logullo, +3 authors, Luiz Henrique Gebrim.
J Cancer Res Clin Oncol, 2010 Oct 05; 137(5). PMID: 20886231
Correlation of high 18F-FDG uptake to clinical, pathological and biological prognostic factors in breast cancer.
David Groheux, Sylvie Giacchetti, +8 authors, Elif Hindié.
Eur J Nucl Med Mol Imaging, 2010 Nov 09; 38(3). PMID: 21057787
Highly Cited.
Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS).
Alastair M Thompson, Lee B Jordan, +5 authors, Breast Recurrence in Tissues Study Group.
Breast Cancer Res, 2010 Nov 10; 12(6). PMID: 21059212    Free PMC article.
Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome.
Laura P Stabile, Sanja Dacic, +6 authors, Jill M Siegfried.
Clin Cancer Res, 2010 Nov 11; 17(1). PMID: 21062926    Free PMC article.
The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression.
Ankur Sharma, Wen-Shuz Yeow, +11 authors, Karen E Knudsen.
J Clin Invest, 2010 Nov 26; 120(12). PMID: 21099110    Free PMC article.
Highly Cited.
Promoter CpG island hypermethylation during breast cancer progression.
So Yeon Park, Hyeong Ju Kwon, +7 authors, Gyeong Hoon Kang.
Virchows Arch, 2010 Dec 02; 458(1). PMID: 21120523
Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling.
Ying Qu, Jinhua Wang, +13 authors, Xiaojiang Cui.
J Clin Invest, 2010 Dec 03; 121(1). PMID: 21123948    Free PMC article.
Reduced dose and intermittent treatment with lapatinib and trastuzumab for potent blockade of the HER pathway in HER2/neu-overexpressing breast tumor xenografts.
Mothaffar F Rimawi, Lisa S Wiechmann, +11 authors, Rachel Schiff.
Clin Cancer Res, 2010 Dec 09; 17(6). PMID: 21138857    Free PMC article.
Invasive Lobular Carcinomas Do Not Express Basal Cytokeratin Markers CK5/6, CK14 and CK17.
Natalya Khilko, Jianmin Wang, +2 authors, Ping Tang.
Breast Cancer (Auckl), 2010 Dec 15; 4. PMID: 21151863    Free PMC article.
Clinicopathlogic and immunohistochemical characteristics of triple negative invasive lobular carcinoma.
Ja Seung Koo, Woohee Jung.
Yonsei Med J, 2010 Dec 15; 52(1). PMID: 21155040    Free PMC article.
Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration.
Ji Wang, Robert F Place, +5 authors, Long-Cheng Li.
Cancer Res, 2010 Dec 17; 70(24). PMID: 21159640    Free PMC article.
P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.
Robin Fuchs-Young, Stephanie H Shirley, +7 authors, Stephen D Hursting.
Breast Cancer Res Treat, 2010 Dec 31; 130(2). PMID: 21191649    Free PMC article.
Syndecan-1 in breast cancer stroma fibroblasts regulates extracellular matrix fiber organization and carcinoma cell motility.
Ning Yang, Rachel Mosher, +2 authors, Andreas Friedl.
Am J Pathol, 2011 Jan 13; 178(1). PMID: 21224069    Free PMC article.
Technical note on the validation of a semi-automated image analysis software application for estrogen and progesterone receptor detection in breast cancer.
László Krecsák, Tamás Micsik, +8 authors, Béla Molnár.
Diagn Pathol, 2011 Jan 20; 6. PMID: 21244664    Free PMC article.
Vascular characterisation of triple negative breast carcinomas using dynamic MRI.
Sonia P Li, Anwar R Padhani, +6 authors, Andreas Makris.
Eur Radiol, 2011 Jan 25; 21(7). PMID: 21258931
HER2-positive circulating tumor cells in breast cancer.
Michail Ignatiadis, Françoise Rothé, +17 authors, Christos Sotiriou.
PLoS One, 2011 Jan 26; 6(1). PMID: 21264346    Free PMC article.
Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing.
A Riaño, D Ortiz-Masià, +3 authors, Maria Dolores Barrachina.
J Gastroenterol, 2011 Feb 10; 46(5). PMID: 21305324
Prognostic impact of S100A9 overexpression in non-small cell lung cancer.
Hideki Kawai, Yoshihiro Minamiya, Naoko Takahashi.
Tumour Biol, 2011 Mar 04; 32(4). PMID: 21369941
Implementation of External Quality Assurance Trials for Immunohistochemically Determined Breast Cancer Biomarkers in Germany.
Reinhard von Wasielewski, Claudia A Krusche, +2 authors, Hans Kreipe.
Breast Care (Basel), 2008 Jan 01; 3(2). PMID: 21373217    Free PMC article.
A feedback loop between androgen receptor and ERK signaling in estrogen receptor-negative breast cancer.
Kee Ming Chia, Ji Liu, Glenn D Francis, Ali Naderi.
Neoplasia, 2011 Mar 16; 13(2). PMID: 21403841    Free PMC article.
EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis.
Gilbert Spizzo, Dominic Fong, +6 authors, Philip Went.
J Clin Pathol, 2011 Mar 19; 64(5). PMID: 21415054    Free PMC article.
Estrogen receptor and progesterone receptor as predictive biomarkers of response to endocrine therapy: a prospectively powered pathology study in the Tamoxifen and Exemestane Adjuvant Multinational trial.
John M S Bartlett, Cassandra L Brookes, +15 authors, Daniel Rea.
J Clin Oncol, 2011 Mar 23; 29(12). PMID: 21422407    Free PMC article.
CK8/18 expression, the basal phenotype, and family history in identifying BRCA1-associated breast cancer in the Ontario site of the breast cancer family registry.
Anna Marie Mulligan, Dushanthi Pinnaduwage, +3 authors, Irene L Andrulis.
Cancer, 2011 Mar 23; 117(7). PMID: 21425134    Free PMC article.
Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma.
Maria E Lendorf, Tina Manon-Jensen, +2 authors, John R Couchman.
J Histochem Cytochem, 2011 Mar 25; 59(6). PMID: 21430259    Free PMC article.
Progesterone receptor isoform-specific promoter methylation: association of PRA promoter methylation with worse outcome in breast cancer patients.
Thushangi N Pathiraja, Priya B Shetty, +6 authors, Steffi Oesterreich.
Clin Cancer Res, 2011 Apr 05; 17(12). PMID: 21459801    Free PMC article.
Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas.
Ping Zhan, Xiao-Kun Shen, +9 authors, Li-Ke Yu.
Med Oncol, 2011 Apr 27; 29(2). PMID: 21519871
Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments.
Ada Ao, Brian J Morrison, +3 authors, Jianrong Lu.
PLoS One, 2011 May 03; 6(4). PMID: 21533195    Free PMC article.
The significance of HER-2/neu receptor positivity and immunophenotype in ductal carcinoma in situ with early invasive disease.
Shuko Harada, Rosemarie Mick, +7 authors, Paul J Zhang.
J Surg Oncol, 2011 May 11; 104(5). PMID: 21557226    Free PMC article.
Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.
Xin Pan, Tao Zhou, +19 authors, Xue-Min Zhang.
Nat Med, 2011 May 17; 17(6). PMID: 21572428
Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type.
David H Nguyen, Hellen A Oketch-Rabah, +12 authors, Mary Helen Barcellos-Hoff.
Cancer Cell, 2011 May 18; 19(5). PMID: 21575864    Free PMC article.
Biologic markers determine both the risk and the timing of recurrence in breast cancer.
Laura J Esserman, Dan H Moore, +11 authors, Christopher C Benz.
Breast Cancer Res Treat, 2011 May 21; 129(2). PMID: 21597921    Free PMC article.
The changing role of pathology in breast cancer diagnosis and treatment.
Anthony S-Y Leong, Zhengping Zhuang.
Pathobiology, 2011 Jun 17; 78(2). PMID: 21677473    Free PMC article.
Review.
Increased 5α-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation.
Niramol Chanplakorn, Pongsthorn Chanplakorn, +7 authors, Hironobu Sasano.
Horm Cancer, 2011 Jul 16; 2(1). PMID: 21761341
Quantitative immunohistochemical analysis and prognostic significance of TRPS-1, a new GATA transcription factor family member, in breast cancer.
Jie Qing Chen, Jennifer Litton, +12 authors, Laszlo Radvanyi.
Horm Cancer, 2010 Feb 01; 1(1). PMID: 21761348
Can lymphatic vascular density be used in determining metastatic spreading potential of tumor in invasive ductal carcinomas?
Nilufer Onak Kandemir, Figen Barut, Sibel Bektas, Sukru Oguz Ozdamar.
Pathol Oncol Res, 2011 Jul 26; 18(2). PMID: 21785902
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), C Davies, +11 authors, R Peto.
Lancet, 2011 Aug 02; 378(9793). PMID: 21802721    Free PMC article.
Highly Cited.
Modified primary tumour/vessel tumour/nodal tumour classification for patients with invasive ductal carcinoma of the breast.
T Hasebe, M Iwasaki, +5 authors, H Tsuda.
Br J Cancer, 2011 Aug 04; 105(5). PMID: 21811256    Free PMC article.
SEOM clinical guidelines for using molecular markers in clinical practice.
Virginia Arrazubi, Roberto Pazo, Dolores Isla, José Luis Pérez Gracia.
Clin Transl Oncol, 2011 Aug 09; 13(8). PMID: 21821495
Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells.
Binoj C Nair, Sreeram Vallabhaneni, Rajeshwar R Tekmal, Ratna K Vadlamudi.
Breast Cancer Res, 2011 Aug 13; 13(3). PMID: 21834972    Free PMC article.
Impact of low estrogen/progesterone receptor expression on survival outcomes in breast cancers previously classified as triple negative breast cancers.
Kanwal P S Raghav, Leonel F Hernandez-Aya, +7 authors, Ana M Gonzalez-Angulo.
Cancer, 2011 Aug 13; 118(6). PMID: 21837669    Free PMC article.
Estrogen receptor degradation: a CUE for endocrine resistance?
Elizabeth A Musgrove.
Breast Cancer Res, 2011 Aug 25; 13(4). PMID: 21861853    Free PMC article.
Review.
Estrogen receptor (ESR1) mRNA expression and benefit from tamoxifen in the treatment and prevention of estrogen receptor-positive breast cancer.
Chungyeul Kim, Gong Tang, +18 authors, Soonmyung Paik.
J Clin Oncol, 2011 Sep 29; 29(31). PMID: 21947828    Free PMC article.
Ki 67 is a major, but not the sole determinant of Oncotype Dx recurrence score.
S Sahebjam, R Aloyz, +6 authors, L C Panasci.
Br J Cancer, 2011 Oct 06; 105(9). PMID: 21970880    Free PMC article.
Tailoring therapy for locally advanced breast cancer using molecular profiles: are we there yet?
Christopher Fosker, Julian W Adlard, Abeer Shaaban.
Drugs, 2011 Oct 12; 71(15). PMID: 21985164
Expression of E-cadherin, N-cadherin and snail and their correlation with clinicopathological variants: an immunohistochemical study of 132 invasive ductal breast carcinomas in Egypt.
Hanan Mohamed Abd ElMoneim, Nasser Mohammed Zaghloul.
Clinics (Sao Paulo), 2011 Oct 21; 66(10). PMID: 22012049    Free PMC article.
Immunophenotypic and genomic characterization of papillary carcinomas of the breast.
Raphaëlle Duprez, Paul M Wilkerson, +15 authors, Jorge S Reis-Filho.
J Pathol, 2011 Oct 26; 226(3). PMID: 22025283    Free PMC article.
The prognostic analysis of clinical breast cancer subtypes among patients with liver metastases from breast cancer.
Xiao Feng Duan, Na Na Dong, Ti Zhang, Qiang Li.
Int J Clin Oncol, 2011 Nov 02; 18(1). PMID: 22041927
In vivo magnetic resonance imaging of the estrogen receptor in an orthotopic model of human breast cancer.
Adi Pais, Chidambaram Gunanathan, +4 authors, Hadassa Degani.
Cancer Res, 2011 Nov 02; 71(24). PMID: 22042793    Free PMC article.
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α.
F Vesuna, A Lisok, +8 authors, V Raman.
Oncogene, 2011 Nov 08; 31(27). PMID: 22056872    Free PMC article.
Dietary intakes of total and specific lignans are associated with clinical breast tumor characteristics.
Susan E McCann, Katie C Hootman, +7 authors, Swati A Kulkarni.
J Nutr, 2011 Nov 25; 142(1). PMID: 22113872    Free PMC article.
Factors associated with concordant estrogen receptor expression at diagnosis and centralized re-assay in a Danish population-based breast cancer study.
Deirdre P Cronin-Fenton, Ylva Hellberg, +7 authors, Stephen Hamilton-Dutoit.
Acta Oncol, 2011 Dec 02; 51(2). PMID: 22129357    Free PMC article.
Practical implications of gene-expression-based assays for breast oncologists.
Aleix Prat, Matthew J Ellis, Charles M Perou.
Nat Rev Clin Oncol, 2011 Dec 07; 9(1). PMID: 22143140    Free PMC article.
Highly Cited. Review.
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression.
J N Anastas, T L Biechele, +4 authors, R T Moon.
Oncogene, 2011 Dec 20; 31(32). PMID: 22179838    Free PMC article.
Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans.
Atsuko Yoneda, Maria E Lendorf, John R Couchman, Hinke A B Multhaupt.
J Histochem Cytochem, 2011 Dec 30; 60(1). PMID: 22205677    Free PMC article.
Review.
STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas.
Szeman Ruby Chan, William Vermi, +10 authors, Robert D Schreiber.
Breast Cancer Res, 2012 Jan 24; 14(1). PMID: 22264274    Free PMC article.
Highly Cited.
Comparison of ER/PR and HER2 statuses in primary and paired liver metastatic sites of breast carcinoma in patients with or without treatment.
Jieqiong Liu, Heran Deng, +7 authors, Fengxi Su.
J Cancer Res Clin Oncol, 2012 Feb 01; 138(5). PMID: 22290394
Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers.
Nicola J Lomas, Keira L Watts, +2 authors, Monica A Spiteri.
Int J Clin Exp Pathol, 2012 Feb 02; 5(1). PMID: 22295148    Free PMC article.
Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.
Natsumi Hasegawa, Akiko Sumitomo, +11 authors, Mitsuhiro Ito.
Mol Cell Biol, 2012 Feb 15; 32(8). PMID: 22331469    Free PMC article.
The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer.
Gustaf Rosin, Ulf Hannelius, +4 authors, Juha Kere.
BMC Cancer, 2012 Mar 02; 12. PMID: 22375924    Free PMC article.
Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24.
D Craig Allred, Stewart J Anderson, +9 authors, Norman Wolmark.
J Clin Oncol, 2012 Mar 07; 30(12). PMID: 22393101    Free PMC article.
Hormonal therapy in breast cancer: a model disease for the personalization of cancer care.
Shannon Puhalla, Saveri Bhattacharya, Nancy E Davidson.
Mol Oncol, 2012 Mar 13; 6(2). PMID: 22406404    Free PMC article.
Review.
ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer.
Isabel Pinhel, Margaret Hills, +10 authors, NCRI Adjuvant Breast Cancer Trial Management Group.
Breast Cancer Res, 2012 Mar 16; 14(2). PMID: 22417870    Free PMC article.
Development of multigene expression signature maps at the protein level from digitized immunohistochemistry slides.
Gregory J Metzger, Stephen C Dankbar, +3 authors, Stephen C Schmechel.
PLoS One, 2012 Mar 23; 7(3). PMID: 22438942    Free PMC article.
Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study.
Katja Lundgren, Matthew Brown, +7 authors, TransATAC investigators.
Breast Cancer Res, 2012 Apr 06; 14(2). PMID: 22475046    Free PMC article.
Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.
S Hector, S Conlon, +6 authors, J H M Prehn.
Br J Cancer, 2012 Apr 07; 106(9). PMID: 22481083    Free PMC article.
Prognostic Significance of High Expression of ER-beta in Surgically Treated ER-Positive Breast Cancer Following Endocrine Therapy.
Tae-Jung Kim, Ahwon Lee, +3 authors, Chang Suk Kang.
J Breast Cancer, 2012 Apr 12; 15(1). PMID: 22493632    Free PMC article.
Importance of assessing CK19 immunostaining in core biopsies in patients subjected to sentinel node study by OSNA.
Felip Vilardell, Anna Novell, +9 authors, Xavier Matias-Guiu.
Virchows Arch, 2012 May 05; 460(6). PMID: 22555942    Free PMC article.
(-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury.
Waleed M Renno, May Al-Maghrebi, Anwar Al-Banaw.
Naunyn Schmiedebergs Arch Pharmacol, 2012 May 11; 385(8). PMID: 22573016
Multiplexed quantification of estrogen receptor and HER2/Neu in tissue and cell lysates by peptide immunoaffinity enrichment mass spectrometry.
Regine M Schoenherr, Jeffrey R Whiteaker, +7 authors, Amanda G Paulovich.
Proteomics, 2012 May 12; 12(8). PMID: 22577026    Free PMC article.
Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study.
Rebecca Ritte, Annekatrin Lukanova, +44 authors, Rudolf Kaaks.
Breast Cancer Res, 2012 May 16; 14(3). PMID: 22583394    Free PMC article.
Poor-prognosis estrogen receptor- positive disease: present and future clinical solutions.
Per E Lønning.
Ther Adv Med Oncol, 2012 May 17; 4(3). PMID: 22590486    Free PMC article.
Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo.
Danielle Meijer, Hans Gelderblom, +3 authors, Judith V M G Bovee.
Clin Sarcoma Res, 2012 May 23; 1(1). PMID: 22613849    Free PMC article.
Estrogen receptor testing and 10-year mortality from breast cancer: A model for determining testing strategy.
Christopher Naugler.
J Pathol Inform, 2012 May 23; 3. PMID: 22616031    Free PMC article.
ESR1 gene status correlates with estrogen receptor protein levels measured by ligand binding assay and immunohistochemistry.
Anne-Vibeke Laenkholm, Ann Knoop, +6 authors, Kirsten Vang Nielsen.
Mol Oncol, 2012 May 26; 6(4). PMID: 22626971    Free PMC article.
Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation.
Aritro Sen, Ismary De Castro, +6 authors, Stephen R Hammes.
J Clin Invest, 2012 Jun 12; 122(7). PMID: 22684108    Free PMC article.
Slug, a unique androgen-regulated transcription factor, coordinates androgen receptor to facilitate castration resistance in prostate cancer.
Kaijie Wu, Crystal Gore, +10 authors, Jer-Tsong Hsieh.
Mol Endocrinol, 2012 Jun 30; 26(9). PMID: 22745193    Free PMC article.
A phase II trial to assess efficacy and safety of afatinib in extensively pretreated patients with HER2-negative metastatic breast cancer.
Martin Schuler, Ahmad Awada, +17 authors, Nadia Harbeck.
Breast Cancer Res Treat, 2012 Jul 06; 134(3). PMID: 22763464    Free PMC article.
Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.
Alexander D Borowsky, Padmavathi Bandhuvula, +10 authors, Julie D Saba.
J Lipid Res, 2012 Jul 12; 53(9). PMID: 22781001    Free PMC article.
p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells.
Crystal E Berger, Yingjuan Qian, +2 authors, Xinbin Chen.
J Biol Chem, 2012 Jul 13; 287(36). PMID: 22787161    Free PMC article.
Quantitative analysis of estrogen receptor expression shows SP1 antibody is more sensitive than 1D5.
Allison W Welsh, Malini Harigopal, +2 authors, David L Rimm.
Appl Immunohistochem Mol Morphol, 2012 Jul 24; 21(2). PMID: 22820659    Free PMC article.
Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-Seq data.
Kathryn J Huber-Keener, Xiuping Liu, +11 authors, Rongling Wu.
PLoS One, 2012 Jul 31; 7(7). PMID: 22844461    Free PMC article.
A human-computer collaborative approach to identifying common data elements in clinical trial eligibility criteria.
Zhihui Luo, Riccardo Miotto, Chunhua Weng.
J Biomed Inform, 2012 Aug 01; 46(1). PMID: 22846169    Free PMC article.
Characterization of estrogen-receptor-targeted contrast agents in solution, breast cancer cells, and tumors in vivo.
Adi Pais, Inbal Eti Biton, Raanan Margalit, Hadassa Degani.
Magn Reson Med, 2012 Aug 14; 70(1). PMID: 22887470    Free PMC article.
The effect of prolonged cold ischemia time on estrogen receptor immunohistochemistry in breast cancer.
Xiaoxian Li, Michael T Deavers, +5 authors, Lei Huo.
Mod Pathol, 2012 Aug 18; 26(1). PMID: 22899286    Free PMC article.
Differential expression patterns of estrogen receptor (ER)-β splice variants between papillary thyroid cancer and nodular thyroid goiter.
Wenwu Dong, Jing Li, +3 authors, Weiping Teng.
Med Sci Monit, 2012 Sep 01; 18(9). PMID: 22936184    Free PMC article.
Factors that influence the incidence of breast cancer in Arica, Chile (Review).
Gloria M Calaf, Fresia Caba, Jorge Farias, Francisco Rothhammer.
Oncol Lett, 2010 Jul 01; 1(4). PMID: 22966347    Free PMC article.
Predictive significance of the proportion of ER-positive or PgR-positive tumor cells in response to neoadjuvant chemotherapy for operable HER2-negative breast cancer.
Tomofumi Osako, Reiki Nishimura, +2 authors, Nobuyuki Arima.
Exp Ther Med, 2012 Sep 13; 3(1). PMID: 22969846    Free PMC article.
Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors.
Ke-Feng Lei, Bing-Ya Liu, +4 authors, Zheng-Gang Zhu.
Exp Ther Med, 2012 Sep 13; 3(1). PMID: 22969854    Free PMC article.
Prognostic value of nuclear maspin expression for adjuvant 5-fluorouracil-based chemotherapy in advanced gastric cancer.
Ke-Feng Lei, Bing-Ya Liu, +3 authors, Zheng-Gang Zhu.
Exp Ther Med, 2012 Sep 13; 3(6). PMID: 22970005    Free PMC article.
Expression of DBC1 is associated with nuclear grade and HER2 expression in breast cancer.
Haruko Hiraike, Osamu Wada-Hiraike, +10 authors, Yuji Taketani.
Exp Ther Med, 2012 Sep 15; 2(6). PMID: 22977628    Free PMC article.
A logistic regression model for predicting axillary lymph node metastases in early breast carcinoma patients.
Fei Xie, Houpu Yang, +4 authors, Jiaqing Zhang.
Sensors (Basel), 2012 Sep 27; 12(7). PMID: 23012578    Free PMC article.
Elevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrence.
Carolyn L Smith, Ilenia Migliaccio, +8 authors, Steffi Oesterreich.
Breast Cancer Res Treat, 2012 Sep 28; 136(1). PMID: 23015261    Free PMC article.
Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer.
Antonia Sophie Wenners, Keyur Mehta, +16 authors, Maret Bauer.
PLoS One, 2012 Oct 12; 7(10). PMID: 23056218    Free PMC article.
Invasive pleomorphic lobular carcinoma of the breast: clinicopathologic characteristics and prognosis compared with invasive ductal carcinoma.
Seung Pil Jung, Se Kyoung Lee, +11 authors, Jeong Eon Lee.
J Breast Cancer, 2012 Oct 24; 15(3). PMID: 23091544    Free PMC article.
Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX.
Alan S Coates, Ewan K A Millar, +10 authors, Robert L Sutherland.
Breast Cancer Res, 2012 Nov 07; 14(6). PMID: 23127292    Free PMC article.
Cooperating transcription factors mediate the function of estrogen receptor.
Elisa Fiorito, Madhumohan R Katika, Antoni Hurtado.
Chromosoma, 2012 Nov 30; 122(1-2). PMID: 23192763    Free PMC article.
Review.
Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry.
Anna Marie Mulligan, Irene Raitman, +5 authors, Irene L Andrulis.
Clin Cancer Res, 2012 Dec 06; 19(2). PMID: 23213058    Free PMC article.
The neuropeptide y y(1) receptor: a diagnostic marker? Expression in mcf-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts.
Martin Memminger, Max Keller, +4 authors, Armin Buschauer.
PLoS One, 2012 Dec 14; 7(12). PMID: 23236424    Free PMC article.
Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization.
Jan Budczies, Frederick Klauschen, +4 authors, Carsten Denkert.
PLoS One, 2012 Dec 20; 7(12). PMID: 23251644    Free PMC article.
Highly Cited.
Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.
Bin Xue, Kannan Krishnamurthy, D Craig Allred, Senthil K Muthuswamy.
Nat Cell Biol, 2012 Dec 25; 15(2). PMID: 23263278    Free PMC article.
Highly Cited.
PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1.
Giulia Pinton, Arcangela Gabriella Manente, +3 authors, Laura Moro.
J Cell Mol Med, 2013 Jan 11; 17(2). PMID: 23301673    Free PMC article.
New and emerging treatments for estrogen receptor-positive breast cancer: focus on everolimus.
Elisavet Paplomata, Ruth O'Regan.
Ther Clin Risk Manag, 2013 Jan 25; 9. PMID: 23345981    Free PMC article.
Involvement of estrogen receptor β5 in the progression of glioma.
Wenjun Li, Ali Winters, +8 authors, Shao-Hua Yang.
Brain Res, 2013 Feb 13; 1503. PMID: 23399685    Free PMC article.
Expression of C-X-C chemokine receptor types 1/2 in patients with gastric carcinoma: Clinicopathological correlations and significance.
Jun Pu Wang, Wan Ming Hu, +13 authors, Ji Fang Wen.
Oncol Lett, 2013 Feb 20; 5(2). PMID: 23420470    Free PMC article.
GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness.
Katherine U Gaynor, Irina V Grigorieva, +7 authors, Rajesh V Thakker.
Horm Cancer, 2013 Feb 26; 4(3). PMID: 23435732
Oestrogen receptors are prognostic factors in malignant peritoneal mesothelioma.
Krishna Pillai, Mohammad Hossein Pourgholami, Terence C Chua, David Lawson Morris.
J Cancer Res Clin Oncol, 2013 Mar 07; 139(6). PMID: 23463097
Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas.
Sveinung W Sorbye, Thomas K Kilvaer, +5 authors, Lill-Tove Busund.
BMC Clin Pathol, 2013 Mar 19; 13. PMID: 23497154    Free PMC article.
Upregulated hPuf-A promotes breast cancer tumorigenesis.
Chi-Chen Fan, Liek-Yeow Lee, +3 authors, Mau-Sun Chang.
Tumour Biol, 2013 Apr 30; 34(5). PMID: 23625657
Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy.
Mamoru Takada, Toru Higuchi, +10 authors, Yasuhiko Kaneko.
BMC Cancer, 2013 May 18; 13. PMID: 23679233    Free PMC article.
Management of adverse events in patients with hormone receptor-positive breast cancer treated with everolimus: observations from a phase III clinical trial.
Mary E Peterson.
Support Care Cancer, 2013 May 21; 21(8). PMID: 23686401    Free PMC article.
Review.
Development of new estrogen receptor-targeting therapeutic agents for tamoxifen-resistant breast cancer.
Quan Jiang, Shilong Zheng, Guangdi Wang.
Future Med Chem, 2013 Jun 06; 5(9). PMID: 23734685    Free PMC article.
Review.
[Breast cancer: current recommendations for pathologists on the basis of the S3 guidelines].
A Lebeau, H Kreipe, +2 authors, R Kreienberg.
Pathologe, 2013 Jun 25; 34(4). PMID: 23793365
The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.
Xue-Min Yu, Ying Liu, +4 authors, Xin-Liang Pan.
PLoS One, 2013 Jun 28; 8(6). PMID: 23805287    Free PMC article.
Clinical-pathologic significance of cancer stem cell marker expression in familial breast cancers.
Anita Bane, Alicia Viloria-Petit, +3 authors, Irene L Andrulis.
Breast Cancer Res Treat, 2013 Jul 03; 140(1). PMID: 23813303    Free PMC article.
Estrogen receptor beta 2 is associated with poor prognosis in estrogen receptor alpha-negative breast carcinoma.
Nuiki Iota Chantzi, Dina G Tiniakos, +6 authors, Muichael N Alexis.
J Cancer Res Clin Oncol, 2013 Jul 03; 139(9). PMID: 23817696
An associated classification of triple negative breast cancer: the risk of relapse and the response to chemotherapy.
Jing Zhang, Yahong Wang, +3 authors, Yun Niu.
Int J Clin Exp Pathol, 2013 Jul 05; 6(7). PMID: 23826420    Free PMC article.
Does the expression of BCL2 have prognostic significance in malignant peritoneal mesothelioma?
Krishna Pillai, Mohammad H Pourgholami, Terence C Chua, David L Morris.
Am J Cancer Res, 2013 Jul 11; 3(3). PMID: 23841030    Free PMC article.
Boron-Based 4-Hydroxytamoxifen Bioisosteres for Treatment of de Novo Tamoxifen Resistant Breast Cancer.
Quan Jiang, Qiu Zhong, +2 authors, Guangdi Wang.
ACS Med Chem Lett, 2012 Apr 06; 3(5). PMID: 23864928    Free PMC article.
Genes dysregulated to different extent or oppositely in estrogen receptor-positive and estrogen receptor-negative breast cancers.
Xianxiao Zhou, Tongwei Shi, +6 authors, Zheng Guo.
PLoS One, 2013 Jul 23; 8(7). PMID: 23875016    Free PMC article.
Shrink pattern of breast cancer after neoadjuvant chemotherapy and its correlation with clinical pathological factors.
Shushu Wang, Yi Zhang, +4 authors, Jun Jiang.
World J Surg Oncol, 2013 Jul 26; 11(1). PMID: 23883300    Free PMC article.
EP1: a novel rabbit monoclonal antibody for detection of oestrogen receptor α.
Sunil Badve, I Tudor Vladislav, +6 authors, Therese Phillips.
J Clin Pathol, 2013 Jul 31; 66(12). PMID: 23894168    Free PMC article.
Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics.
Floris H Groenendijk, Wilbert Zwart, +2 authors, Rene Bernards.
Breast Cancer Res Treat, 2013 Aug 06; 140(3). PMID: 23912957    Free PMC article.
Ki67-BCL2 index in prognosis of malignant peritoneal mesothelioma.
Krishna Pillai, Mohammad H Pourgholami, Terence C Chua, David L Morris.
Am J Cancer Res, 2013 Aug 27; 3(4). PMID: 23977450    Free PMC article.
Survival Analysis Based on Clinicopathological Data from a Single Institution: Chemotherapy Intensity Would Be Enhanced in Patients with Positive Hormone Receptors and Positive HER2 in China Who Cannot Afford the Target Therapy.
Jianyi Li, Shi Jia, +3 authors, Rui Tian.
ISRN Oncol, 2013 Aug 29; 2013. PMID: 23984097    Free PMC article.
Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study.
V Luyckx, J F Durant, +7 authors, M M Dolmans.
J Assist Reprod Genet, 2013 Aug 31; 30(10). PMID: 23989997    Free PMC article.
Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling.
Xi Zhang, Xin Mu, +4 authors, Kunwei Shen.
PLoS One, 2013 Aug 31; 8(8). PMID: 23991038    Free PMC article.
Clinical relevance of the reappraisal of negative hormone receptor expression in breast cancer.
António E Pinto, Filipa Areia, +5 authors, Saudade André.
Springerplus, 2013 Sep 07; 2. PMID: 24010033    Free PMC article.
Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control.
Emanuele de Rinaldis, Patrycja Gazinska, +10 authors, Andrew Tutt.
BMC Genomics, 2013 Sep 26; 14. PMID: 24059244    Free PMC article.
Simultaneous disruption of estrogen receptor and Wnt/β-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats.
Animesh Mandal, Deepak Bhatia, Anupam Bishayee.
Mol Cell Biochem, 2013 Oct 01; 384(1-2). PMID: 24078029    Free PMC article.
Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection.
Trine Tramm, Guido Hennig, +5 authors, Jens Overgaard.
Virchows Arch, 2013 Oct 09; 463(6). PMID: 24100522
Endocrine resistance in breast cancer: Current status and a perspective on the roles of miRNAs (Review).
Jichun Zhou, Rongyue Teng, +7 authors, Shuduo Xie.
Oncol Lett, 2013 Oct 19; 6(2). PMID: 24137320    Free PMC article.
P16 and p53 play distinct roles in different subtypes of breast cancer.
Ming Shan, Xianyu Zhang, +8 authors, Da Pang.
PLoS One, 2013 Oct 23; 8(10). PMID: 24146864    Free PMC article.
Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer.
X Q Zheng, J P Guo, +9 authors, J Q Cheng.
Oncogene, 2013 Oct 30; 33(42). PMID: 24166501    Free PMC article.
A phase 2 study of 16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC).
Lanell M Peterson, Brenda F Kurland, +8 authors, Hannah M Linden.
Mol Imaging Biol, 2013 Oct 31; 16(3). PMID: 24170452    Free PMC article.
Sox2 promotes tamoxifen resistance in breast cancer cells.
Marco Piva, Giacomo Domenici, +8 authors, Maria d M Vivanco.
EMBO Mol Med, 2013 Nov 02; 6(1). PMID: 24178749    Free PMC article.
Highly Cited.
Spectrum of EGFR gene copy number changes and KRAS gene mutation status in Korean triple negative breast cancer patients.
Yoonjung Kim, Juwon Kim, +3 authors, Kyung-A Lee.
PLoS One, 2013 Nov 10; 8(10). PMID: 24205362    Free PMC article.
Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
Rupninder Sandhu, Ashley G Rivenbark, +2 authors, William B Coleman.
Int J Oncol, 2013 Dec 04; 44(2). PMID: 24297604    Free PMC article.
Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study.
C A Purdie, P Quinlan, +4 authors, A M Thompson.
Br J Cancer, 2013 Dec 05; 110(3). PMID: 24300977    Free PMC article.
Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?
Anna Markowska, Monika Pawałowska, +8 authors, Janina Markowska.
Diabetol Metab Syndr, 2013 Dec 07; 5(1). PMID: 24308813    Free PMC article.
Weakly hormone receptor-positive breast cancer and use of adjuvant hormonal therapy.
Cassandra M Lin, Jasbir Jaswal, +2 authors, Muriel Brackstone.
Curr Oncol, 2013 Dec 07; 20(6). PMID: 24311965    Free PMC article.
Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women.
Lori S Tillmans, Robert A Vierkant, +12 authors, Paul J Limburg.
Cancer Epidemiol Biomarkers Prev, 2013 Dec 18; 23(2). PMID: 24343843    Free PMC article.
Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis.
Chao Sun, Hai-Long Li, +3 authors, Jun-Nian Zheng.
J Cancer Res Clin Oncol, 2013 Dec 29; 140(2). PMID: 24370685
Review.
Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases.
Thaer Khoury, Rouzan G Karabakhtsian, +5 authors, Mohamed M Desouki.
Histopathology, 2014 Jan 01; 64(7). PMID: 24372322    Free PMC article.
Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast.
Rachael Natrajan, Paul M Wilkerson, +24 authors, Jorge S Reis-Filho.
J Pathol, 2014 Jan 08; 232(5). PMID: 24395524    Free PMC article.
Vascular endothelial growth factor receptor-1 expression in breast cancer and its correlation to vascular endothelial growth factor a.
Nahida Srabovic, Zlata Mujagic, +4 authors, Lejla Begic.
Int J Breast Cancer, 2014 Jan 15; 2013. PMID: 24416596    Free PMC article.
Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer.
Congwen Wei, Yuan Cao, +20 authors, Hui Zhong.
Proc Natl Acad Sci U S A, 2014 Jan 23; 111(5). PMID: 24449872    Free PMC article.
Genetically engineered ERα-positive breast cancer mouse models.
Sarah A Dabydeen, Priscilla A Furth.
Endocr Relat Cancer, 2014 Feb 01; 21(3). PMID: 24481326    Free PMC article.
Review.
Nuclear factor-ĸB plays a critical role in both intrinsic and acquired resistance against endocrine therapy in human breast cancer cells.
Kumiko Oida, Akira Matsuda, +9 authors, Akane Tanaka.
Sci Rep, 2014 Feb 18; 4. PMID: 24531845    Free PMC article.
Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53.
Khondoker M Akram, Nicola J Lomas, Nicholas R Forsyth, Monica A Spiteri.
Int J Clin Exp Pathol, 2014 Feb 20; 7(2). PMID: 24551275    Free PMC article.
Which threshold for ER positivity? a retrospective study based on 9639 patients.
M Yi, L Huo, +11 authors, K K Hunt.
Ann Oncol, 2014 Feb 25; 25(5). PMID: 24562447    Free PMC article.
Expression profiling of breast cancer patients treated with tamoxifen: prognostic or predictive significance.
Sanaz Tabarestani, Sayyed Mohammad Hossein Ghaderian, Hamid Rezvani, Reza Mirfakhraie.
Med Oncol, 2014 Feb 25; 31(4). PMID: 24563328
A Majority of Low (1-10%) ER Positive Breast Cancers Behave Like Hormone Receptor Negative Tumors.
Jyothi S Prabhu, Aruna Korlimarla, +12 authors, T S Sridhar.
J Cancer, 2014 Feb 25; 5(2). PMID: 24563670    Free PMC article.
Prognostic and predictive value of copy number alterations in invasive breast cancer as determined by multiplex ligation-dependent probe amplification.
Sanaz Tabarestani, Sayyed Mohammad Hossein Ghaderian, +9 authors, Eznollah Azargashb.
Cell Oncol (Dordr), 2014 Feb 28; 37(2). PMID: 24573687
Complexity in regulation of microRNA machinery components in invasive breast carcinoma.
Sun Young Kwon, Jae-ho Lee, +4 authors, Shin Kim.
Pathol Oncol Res, 2014 Feb 28; 20(3). PMID: 24574065
Extended adjuvant tamoxifen for early breast cancer: a meta-analysis.
Mustafa Al-Mubarak, Ariadna Tibau, +4 authors, Eitan Amir.
PLoS One, 2014 Mar 04; 9(2). PMID: 24586311    Free PMC article.
Systematic Review.
Estrogen receptor-negative breast ductal carcinoma: clinicopathological features and MIB-1 (Ki-67) proliferative index association.
Noorasmaliza Mdpaiman, Siti Aishah Md Ali, +7 authors, Srijit Das.
PLoS One, 2014 Mar 04; 9(2). PMID: 24586570    Free PMC article.
Comparative evaluation of strategies for quantifying signaling pathway proteins in Ewing sarcoma.
Mark A Applebaum, Dafydd G Thomas, +4 authors, Steven G DuBois.
Appl Immunohistochem Mol Morphol, 2014 Mar 05; 22(8). PMID: 24590121    Free PMC article.
Molecular markers for breast cancer: prediction on tumor behavior.
Bruna Karina Banin Hirata, Julie Massayo Maeda Oda, +3 authors, Maria Angelica Ehara Watanabe.
Dis Markers, 2014 Mar 05; 2014. PMID: 24591761    Free PMC article.
Review.
Comparison of cytotoxicity and genotoxicity of 4-hydroxytamoxifen in combination with Tualang honey in MCF-7 and MCF-10A cells.
Nik Soriani Yaacob, Nur Faezah Ismail.
BMC Complement Altern Med, 2014 Mar 22; 14. PMID: 24646375    Free PMC article.
Extended trastuzumab therapy improves the survival of HER2-positive breast cancer patients following surgery and radiotherapy for brain metastases.
Yoshiko Okita, Yoshitaka Narita, +11 authors, Motohiko Maruno.
Mol Clin Oncol, 2014 Mar 22; 1(6). PMID: 24649283    Free PMC article.
Differences in estrogen and progesterone receptor expression in endometrial polyps and atrophic endometrium of postmenopausal women with and without exposure to tamoxifen.
Rogerio Barros Ferreira Leão, Liliana Andrade, +3 authors, Lucia Costa-Paiva.
Mol Clin Oncol, 2014 Mar 22; 1(6). PMID: 24649292    Free PMC article.
Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.
Melanie A Krook, Lauren A Nicholls, +3 authors, Elizabeth R Lawlor.
Mol Cancer Res, 2014 Mar 22; 12(6). PMID: 24651452    Free PMC article.
Expression of cereblon protein assessed by immunohistochemicalstaining in myeloma cells is associated with superior response of thalidomide- and lenalidomide-based treatment, but not bortezomib-based treatment, in patients with multiple myeloma.
Shang-Yi Huang, Chung-Wu Lin, +11 authors, Hwei-Fang Tien.
Ann Hematol, 2014 Apr 02; 93(8). PMID: 24687382    Free PMC article.
SRC-1 and Twist1 expression positively correlates with a poor prognosis in human breast cancer.
Yan Xu, Baoquan Hu, +5 authors, Jun Jiang.
Int J Biol Sci, 2014 Apr 11; 10(4). PMID: 24719557    Free PMC article.
The sodium channel β1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis.
Michaela Nelson, Rebecca Millican-Slater, Lorna C Forrest, William J Brackenbury.
Int J Cancer, 2014 Apr 15; 135(10). PMID: 24729314    Free PMC article.
Study assessing the quality of quantification of estrogen receptor protein expression by immunohistochemistry and gene expression in breast cancer.
Sas Leen, Van Laere Steven, +7 authors, Lardon Filip.
Patholog Res Int, 2014 Apr 16; 2014. PMID: 24734208    Free PMC article.
Longer survival in patients with breast cancer with cyclin d1 over-expression after tumor recurrence: longer, but occupied with disease.
Jaesik Chung, Hany Noh, +2 authors, Airi Han.
J Breast Cancer, 2014 Apr 20; 17(1). PMID: 24744797    Free PMC article.
Vascular measurements correlate with estrogen receptor status.
Mark C Lloyd, Khalid O Alfarouk, +5 authors, Robert A Gatenby.
BMC Cancer, 2014 Apr 24; 14. PMID: 24755315    Free PMC article.
Absence of estrogen receptor alpha (ESR1) gene amplification in a series of breast cancers in Taiwan.
Jim-Ray Chen, Tsan-Yu Hsieh, +8 authors, Yuan-Chun Hsu.
Virchows Arch, 2014 Apr 24; 464(6). PMID: 24756215
Identification of breast cancer patients with a high risk of developing brain metastases: a single-institutional retrospective analysis.
Volker Rudat, Hamdan El-Sweilmeen, +4 authors, Elias Fadel.
BMC Cancer, 2014 Apr 26; 14. PMID: 24761771    Free PMC article.
NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis.
Li Qin, Ye-Lin Wu, +13 authors, Jianming Xu.
Cancer Res, 2014 Apr 29; 74(13). PMID: 24769444    Free PMC article.
Oral health-related complications of breast cancer treatment: assessing dental hygienists' knowledge and professional practice.
L Susan Taichman, Grace Gomez, Marita Rohr Inglehart.
J Dent Hyg, 2014 Apr 29; 88(2). PMID: 24771774    Free PMC article.
Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden.
Khalid Abubaker, Rodney B Luwor, +5 authors, Nuzhat Ahmed.
Front Oncol, 2014 May 02; 4. PMID: 24782986    Free PMC article.
IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples.
Frency Varghese, Amirali B Bukhari, Renu Malhotra, Abhijit De.
PLoS One, 2014 May 08; 9(5). PMID: 24802416    Free PMC article.
Highly Cited.
Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer.
Sarah E Holton, Anna Bergamaschi, Benita S Katzenellenbogen, Rohit Bhargava.
PLoS One, 2014 May 13; 9(5). PMID: 24816718    Free PMC article.
TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy.
Hans P Eikesdal, Stian Knappskog, Turid Aas, Per E Lønning.
Acta Oncol, 2014 Jun 10; 53(10). PMID: 24909504    Free PMC article.
Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps: A comparison between benign and malignant polyps in postmenopausal patients.
Armando Antunes, José Vassallo, +3 authors, Lucia Costa-Paiva.
Oncol Lett, 2014 Jun 17; 7(6). PMID: 24932265    Free PMC article.
KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.
Jianli Wang, Siqin Ma, +5 authors, Yunyun Gong.
BMC Cancer, 2014 Jun 22; 14. PMID: 24950762    Free PMC article.
Estrogen receptor, progesterone receptor, and HER2 status predict lymphovascular invasion and lymph node involvement.
Stacy Ugras, Michelle Stempel, Sujata Patil, Monica Morrow.
Ann Surg Oncol, 2014 Jun 22; 21(12). PMID: 24952028    Free PMC article.
Histopathological characterization of ductal carcinoma in situ (DCIS) of the breast according to HER2 amplification status and molecular subtype.
Mieke Van Bockstal, Kathleen Lambein, +6 authors, Louis Libbrecht.
Virchows Arch, 2014 Jun 30; 465(3). PMID: 24973889
Oestrogen receptors β1 and βcx have divergent roles in breast cancer survival and lymph node metastasis.
G Rosin, J de Boniface, +3 authors, J Hartman.
Br J Cancer, 2014 Jul 16; 111(5). PMID: 25025959    Free PMC article.
Status of adjuvant endocrine therapy for breast cancer.
Gaia Schiavon, Ian E Smith.
Breast Cancer Res, 2014 Jul 18; 16(2). PMID: 25032258    Free PMC article.
Review.
A nation-wide multicenter 10-year (1999-2008) retrospective clinical study of endocrine therapy for Chinese females with breast cancer.
Can Zhou, Jian jun He, +11 authors, Pin Zhang.
PLoS One, 2014 Jul 19; 9(7). PMID: 25036532    Free PMC article.
Expression of estrogen-induced genes and estrogen receptor β in pancreatic neuroendocrine tumors: implications for targeted therapy.
Jeannelyn S Estrella, Ly T Ma, +4 authors, Russell R Broaddus.
Pancreas, 2014 Jul 25; 43(7). PMID: 25058880    Free PMC article.
Evaluation of the Dutch BRCA1/2 clinical genetic center referral criteria in an unselected early breast cancer population.
Alexandra J van den Broek, Karen de Ruiter, +4 authors, Marjanka K Schmidt.
Eur J Hum Genet, 2014 Aug 21; 23(5). PMID: 25138101    Free PMC article.
Genome-based risk prediction for early stage breast cancer.
Christina Adaniel, Komal Jhaveri, Adriana Heguy, Francisco J Esteva.
Oncologist, 2014 Sep 05; 19(10). PMID: 25187476    Free PMC article.
Review.
Impact of intrinsic subtype on predicting axillary lymph node metastasis in breast cancer.
Masataka Sawaki, Ai Idota, +7 authors, Hiroji Iwata.
Oncol Lett, 2014 Sep 10; 8(4). PMID: 25202396    Free PMC article.
Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential.
Hélène Pelicano, Wan Zhang, +5 authors, Peng Huang.
Breast Cancer Res, 2014 Sep 12; 16(5). PMID: 25209360    Free PMC article.
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Xiaoyong Fu, Chad J Creighton, +27 authors, Rachel Schiff.
Breast Cancer Res, 2014 Sep 13; 16(5). PMID: 25212826    Free PMC article.
Contrast enhanced computed tomography is indicative for angiogenesis pattern and display prognostic significance in breast cancer.
Jianyi Li, Yang Zhang, +3 authors, Jiao Guo.
BMC Cancer, 2014 Sep 17; 14. PMID: 25224155    Free PMC article.
Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice.
David H Nguyen, Haoxu Ouyang, +2 authors, Mary Helen Barcellos-Hoff.
Cancer Res, 2014 Oct 05; 74(23). PMID: 25281718    Free PMC article.
Evaluation of BrightGen HR RT-qDx assay to detect nuclear receptors mRNA overexpression in FFPE breast cancer tissue samples for selection of tamoxifen therapy.
Hye-Young Wang, Sangjung Park, +6 authors, Hyeyoung Lee.
Int J Clin Exp Pathol, 2014 Oct 23; 7(9). PMID: 25337220    Free PMC article.
Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples.
Timothy R Wilson, Yuanyuan Xiao, +13 authors, Mark R Lackner.
Breast Cancer Res Treat, 2014 Oct 23; 148(2). PMID: 25338319    Free PMC article.
PELP1 overexpression in the mouse mammary gland results in the development of hyperplasia and carcinoma.
Valerie Cortez, Cathy Samayoa, +3 authors, Ratna K Vadlamudi.
Cancer Res, 2014 Nov 08; 74(24). PMID: 25377474    Free PMC article.
Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor-positive breast cancer.
Costanza Paoletti, Maria C Muñiz, +13 authors, Daniel F Hayes.
Clin Cancer Res, 2014 Nov 09; 21(11). PMID: 25381338    Free PMC article.
Relationship between parameters from virtual touch tissue quantification (VTQ) imaging with clinicopathologic prognostic factors in women with invasive ductal breast cancer.
Juan Xie, Rong Wu, +2 authors, Guang Xu.
Int J Clin Exp Pathol, 2014 Nov 18; 7(10). PMID: 25400743    Free PMC article.
Neogenin expression is inversely associated with breast cancer grade in ex vivo.
Wanying Xing, Qiang Li, Rangjuan Cao, Zheli Xu.
World J Surg Oncol, 2014 Nov 25; 12. PMID: 25416629    Free PMC article.
Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review.
Nickolay Fedchenko, Janin Reifenrath.
Diagn Pathol, 2014 Nov 30; 9. PMID: 25432701    Free PMC article.
Highly Cited. Review.
Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer.
Haitao Li, Xinghua Han, +2 authors, Guomin Dong.
Oncol Lett, 2014 Dec 02; 9(1). PMID: 25435949    Free PMC article.
NFκB affects estrogen receptor expression and activity in breast cancer through multiple mechanisms.
Jonna Frasor, Lamiaa El-Shennawy, Joshua D Stender, Irida Kastrati.
Mol Cell Endocrinol, 2014 Dec 03; 418 Pt 3. PMID: 25450861    Free PMC article.
Review.
Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations.
S Deb, S Q Wong, +9 authors, S B Fox.
Br J Cancer, 2014 Dec 10; 111(12). PMID: 25490678    Free PMC article.
Exploring the spatial dimension of estrogen and progesterone signaling: detection of nuclear labeling in lobular epithelial cells in normal mammary glands adjacent to breast cancer.
Anne Grote, Mahmoud Abbas, +3 authors, Friedrich Feuerhake.
Diagn Pathol, 2015 Jan 08; 9 Suppl 1. PMID: 25565114    Free PMC article.
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Brian M Slomovitz, Yunyun Jiang, +10 authors, Robert L Coleman.
J Clin Oncol, 2015 Jan 28; 33(8). PMID: 25624430    Free PMC article.
Comparison of hormone receptor status in primary and recurrent breast cancer.
Hamid Saeedi Saedi, Mohammad-Reza Ghavam Nasiri, +2 authors, Nama Mohammadian.
Iran J Cancer Prev, 2012 Apr 01; 5(2). PMID: 25628823    Free PMC article.
The use of stereotactic radiosurgery for brain metastases from breast cancer: who benefits most?
Eunpi Cho, Lena Rubinstein, +7 authors, Vijayakrishna K Gadi.
Breast Cancer Res Treat, 2015 Feb 02; 149(3). PMID: 25638395    Free PMC article.
Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance in MCF-7 breast cancer cells by inducing ERα re-expression.
Xia Zhang, Bin Zhang, +9 authors, Yang Zhang.
Sci Rep, 2015 Feb 04; 5. PMID: 25644501    Free PMC article.
A kinetic model identifies phosphorylated estrogen receptor-α (ERα) as a critical regulator of ERα dynamics in breast cancer.
Dan Tian, Natalia M Solodin, +3 authors, Pamela K Kreeger.
FASEB J, 2015 Feb 05; 29(5). PMID: 25648997    Free PMC article.
Associations between Environmental Exposures and Incident Colorectal Cancer by ESR2 Protein Expression Level in a Population-Based Cohort of Older Women.
Lori S Tillmans, Robert A Vierkant, +12 authors, Paul J Limburg.
Cancer Epidemiol Biomarkers Prev, 2015 Feb 05; 24(4). PMID: 25650184    Free PMC article.
Oxidative stress-mediated apoptosis induced by ethanolic mango seed extract in cultured estrogen receptor positive breast cancer MCF-7 cells.
Al-Shwyeh Hussah Abdullah, Abdulkarim Sabo Mohammed, Abdullah Rasedee, Mohamed Elwathig Saeed Mirghani.
Int J Mol Sci, 2015 Feb 11; 16(2). PMID: 25664859    Free PMC article.
Association of CYP2D6*10, OATP1B1 A388G, and OATP1B1 T521C polymorphisms and overall survival of breast cancer patients after tamoxifen therapy.
Xuefeng Zhang, Zhichen Pu, +3 authors, Haitang Xie.
Med Sci Monit, 2015 Feb 24; 21. PMID: 25701109    Free PMC article.
Precision medicine in breast cancer: genes, genomes, and the future of genomically driven treatments.
Daniel G Stover, Nikhil Wagle.
Curr Oncol Rep, 2015 Feb 25; 17(4). PMID: 25708799    Free PMC article.
Review.
The role of chemokine receptor 4 and its ligand stromal cell derived factor 1 in breast cancer.
Binu Kottakkal Aravindan, Jem Prabhakar, Thara Somanathan, Lakshmi Subhadra.
Ann Transl Med, 2015 Mar 05; 3(2). PMID: 25738143    Free PMC article.
Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma.
Jieyu Zhou, Xuemin Yu, +4 authors, Xinliang Pan.
PLoS One, 2015 Mar 21; 10(3). PMID: 25793736    Free PMC article.
Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study.
Ryan J O Dowling, Saroj Niraula, +8 authors, Vuk Stambolic.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849721    Free PMC article.
Uncovering the genomic heterogeneity of multifocal breast cancer.
Christine Desmedt, Debora Fumagalli, +26 authors, Christos Sotiriou.
J Pathol, 2015 Apr 09; 236(4). PMID: 25850943    Free PMC article.
Doxorubicin plus the IGF-1R antibody cixutumumab in soft tissue sarcoma: a phase I study using the TITE-CRM model.
R Chugh, K A Griffith, +7 authors, S M Schuetze.
Ann Oncol, 2015 Apr 11; 26(7). PMID: 25858498    Free PMC article.
Biologic roles of estrogen receptor-β and insulin-like growth factor-2 in triple-negative breast cancer.
Nalo Hamilton, Diana Márquez-Garbán, +7 authors, Richard Pietras.
Biomed Res Int, 2015 Apr 16; 2015. PMID: 25874233    Free PMC article.
Identifying and targeting tumor-initiating cells in the treatment of breast cancer.
Wei Wei, Michael T Lewis.
Endocr Relat Cancer, 2015 Apr 17; 22(3). PMID: 25876646    Free PMC article.
Review.
Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract.
Al-Shwyeh Hussah Abdullah, Abdulkarim Sabo Mohammed, +2 authors, Mothanna Sadiq Al-Qubaisi.
BMC Complement Altern Med, 2015 Apr 17; 15. PMID: 25881293    Free PMC article.
Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations.
Balazs I Bodai, Phillip Tuso.
Perm J, 2015 Apr 23; 19(2). PMID: 25902343    Free PMC article.
Review.
Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estrogen receptor-positive breast cancer.
Xiaoqing Jia, Qi Hong, +8 authors, Guangyu Liu.
Oncotarget, 2015 May 02; 6(11). PMID: 25929338    Free PMC article.
Polymorphism at 19q13.41 Predicts Breast Cancer Survival Specifically after Endocrine Therapy.
Sofia Khan, Rainer Fagerholm, +6 authors, Heli Nevanlinna.
Clin Cancer Res, 2015 May 13; 21(18). PMID: 25964295    Free PMC article.
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade.
Ke Yin.
Onco Targets Ther, 2015 May 23; 8. PMID: 25999742    Free PMC article.
Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy.
Mario Giuliano, Huizhong Hu, +20 authors, Rachel Schiff.
Clin Cancer Res, 2015 May 28; 21(17). PMID: 26015514    Free PMC article.
Adjuvant Metronomic CMF in a Contemporary Breast Cancer Cohort: What's Old Is New.
Eunpi Cho, Ann K Schwemm, +7 authors, Vijayakrishna K Gadi.
Clin Breast Cancer, 2015 May 31; 15(5). PMID: 26025883    Free PMC article.
Quality assessment of estrogen receptor and progesterone receptor testing in breast cancer using a tissue microarray-based approach.
T J A Dekker, S ter Borg, +14 authors, M J van de Vijver.
Breast Cancer Res Treat, 2015 Jun 05; 152(2). PMID: 26041687    Free PMC article.
Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation.
F-F Song, L-L Xia, +9 authors, Y Wang.
Oncogenesis, 2015 Jun 16; 4. PMID: 26075750    Free PMC article.
The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts.
Nipin S P, Pramod Darvin, +13 authors, Young Mok Yang.
BMC Cancer, 2015 Jun 19; 15. PMID: 26084564    Free PMC article.
Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers.
Shozo Honda, Phillipe Loher, +5 authors, Yohei Kirino.
Proc Natl Acad Sci U S A, 2015 Jul 01; 112(29). PMID: 26124144    Free PMC article.
Highly Cited.
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Moloy T Goswami, Guoan Chen, +9 authors, Sooryanarayana Varambally.
Oncotarget, 2015 Jul 04; 6(27). PMID: 26140362    Free PMC article.
Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.
Tilak Khanal, Dasom Kim, +2 authors, Kyounghyun Kim.
Toxicol Lett, 2015 Jul 08; 237(3). PMID: 26149760    Free PMC article.
Differences in Clinical Outcomes between Luminal A and B Type Breast Cancers according to the St. Gallen Consensus 2013.
Hyo Jung Ahn, Soo Jin Jung, +2 authors, Hye-Kyoung Yoon.
J Breast Cancer, 2015 Jul 15; 18(2). PMID: 26155291    Free PMC article.
Axillary Lymph Node-to-Primary Tumor Standard Uptake Value Ratio on Preoperative (18)F-FDG PET/CT: A Prognostic Factor for Invasive Ductal Breast Cancer.
Young Hwan Kim, Hai-Jeon Yoon, Yemi Kim, Bom Sahn Kim.
J Breast Cancer, 2015 Jul 15; 18(2). PMID: 26155294    Free PMC article.
Outcomes of Estrogen Receptor Negative and Progesterone Receptor Positive Breast Cancer.
Melissa Chan, Martin C Chang, +9 authors, Eitan Amir.
PLoS One, 2015 Jul 15; 10(7). PMID: 26161666    Free PMC article.
The role of the pathologist in the decision-making process.
Angelo Paolo Dei Tos.
EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217110    Free PMC article.
Review.
Effect of 21-Gene RT-PCR Assay on Adjuvant Therapy and Outcomes in Patients With Stage I Breast Cancer.
Fanny Le Du, Ana M Gonzalez-Angulo, +3 authors, Naoto T Ueno.
Clin Breast Cancer, 2015 Aug 04; 15(6). PMID: 26233757    Free PMC article.
Selective Targeting to Glioma with Nucleic Acid Aptamers.
Shraddha Aptekar, Mohit Arora, +5 authors, Lisa Shaw.
PLoS One, 2015 Aug 08; 10(8). PMID: 26252900    Free PMC article.
Altered expression of estrogen receptor β2 is associated with different biological markers and clinicopathological factors in papillary thyroid cancer.
Wenwu Dong, Jing Li, +5 authors, Weiping Teng.
Int J Clin Exp Pathol, 2015 Aug 12; 8(6). PMID: 26261608    Free PMC article.
High incidence of germline BRCA mutation in patients with ER low-positive/PR low-positive/HER-2 neu negative tumors.
Rachel A Sanford, Juhee Song, +7 authors, Banu Arun.
Cancer, 2015 Aug 19; 121(19). PMID: 26280679    Free PMC article.
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription.
Li Qin, Yan Xu, +9 authors, Jianming Xu.
Oncotarget, 2015 Aug 20; 6(27). PMID: 26287601    Free PMC article.
Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer.
Francisco J Candido Dos Reis, Stuart Lynn, +43 authors, Paul D P Pharoah.
EBioMedicine, 2015 Aug 20; 2(7). PMID: 26288840    Free PMC article.
Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway.
Wei Song, Wenjie Liu, +21 authors, Linfang Wang.
Nat Commun, 2015 Aug 25; 6. PMID: 26300397    Free PMC article.
Quantitative DCE-MRI for prediction of pathological complete response following neoadjuvant treatment for locally advanced breast cancer: the impact of breast cancer subtypes on the diagnostic accuracy.
Stylianos Drisis, Thierry Metens, +3 authors, Marc Lemort.
Eur Radiol, 2015 Aug 28; 26(5). PMID: 26310583
Copy number analysis of ductal carcinoma in situ with and without recurrence.
Kylie L Gorringe, Sally M Hunter, +9 authors, Ian G Campbell.
Mod Pathol, 2015 Sep 01; 28(9). PMID: 26321097
Oral Health-Related Complications of Breast Cancer Treatment: Assessing Dental Hygienists' Knowledge and Professional Practice.
L Susan Taichman, Grace Gomez, Marita Rohr Inglehart.
J Dent Hyg, 2015 Sep 05; 89 Suppl 2. PMID: 26338905    Free PMC article.
High mobility group B1 and N1 (HMGB1 and HMGN1) are associated with tumor-infiltrating lymphocytes in HER2-positive breast cancers.
Hee Jin Lee, Joo Young Kim, +4 authors, Gyungyub Gong.
Virchows Arch, 2015 Oct 09; 467(6). PMID: 26445971
Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo.
Michaela Nelson, Ming Yang, Rebecca Millican-Slater, William J Brackenbury.
Oncotarget, 2015 Oct 10; 6(32). PMID: 26452220    Free PMC article.
Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.
Yukari Hato, Naoto Kondo, +8 authors, Tatsuya Toyama.
Int J Clin Oncol, 2015 Oct 21; 21(3). PMID: 26482374
St Gallen molecular subtypes in feline mammary carcinoma and paired metastases-disease progression and clinical implications from a 3-year follow-up study.
M Soares, J Correia, M C Peleteiro, F Ferreira.
Tumour Biol, 2015 Oct 22; 37(3). PMID: 26486327
Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer.
Eun-Jin Yun, Jiancheng Zhou, +4 authors, Jer-Tsong Hsieh.
Clin Cancer Res, 2015 Oct 23; 22(3). PMID: 26490309    Free PMC article.
DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis.
J Zhou, Z Ning, +12 authors, K Wu.
Cell Death Dis, 2015 Oct 30; 6. PMID: 26512963    Free PMC article.
Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Cecilie Kyrø, Raul Zamora-Ros, +46 authors, Isabelle Romieu.
Breast Cancer Res Treat, 2015 Nov 05; 154(2). PMID: 26531755    Free PMC article.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
Antonia Wenners, Felix Hartmann, +7 authors, Maret Bauer.
Int J Clin Oncol, 2015 Nov 18; 21(3). PMID: 26573806
Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer.
Jun Yang, Alaa AlTahan, +11 authors, Adrian L Harris.
Proc Natl Acad Sci U S A, 2015 Nov 26; 112(49). PMID: 26598706    Free PMC article.
The PR status of the originating cell of ER/PR-negative mouse mammary tumors.
J Dong, W Zhao, +4 authors, Y Li.
Oncogene, 2015 Dec 08; 35(31). PMID: 26640140    Free PMC article.
Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort.
Anne-Sophie Hamy, Lisa Belin, +8 authors, Fabien Reyal.
Br J Cancer, 2015 Dec 15; 114(1). PMID: 26657653    Free PMC article.
Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium.
Carla Bartosch, Sara Monteiro-Reis, +7 authors, Carmen Jerónimo.
Oncotarget, 2015 Dec 25; 7(2). PMID: 26701732    Free PMC article.
Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study.
Hannah Lui Park, Argyrios Ziogas, +12 authors, Hoda Anton-Culver.
BMC Cancer, 2016 Jan 14; 16. PMID: 26758508    Free PMC article.
Comprehensive Histologic Scoring to Maximize the Predictability of Pathology-generated Equation of Breast Cancer Oncotype DX Recurrence Score.
Thaer Khoury, Xiao Huang, +3 authors, Mateusz Opyrchal.
Appl Immunohistochem Mol Morphol, 2016 Jan 26; 24(10). PMID: 26808126    Free PMC article.
Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells.
Stephanie N Shishido, Thu A Nguyen.
Int J Mol Sci, 2016 Feb 04; 17(2). PMID: 26840298    Free PMC article.
Targeted therapies with companion diagnostics in the management of breast cancer: current perspectives.
Meagan B Myers.
Pharmgenomics Pers Med, 2016 Feb 10; 9. PMID: 26858530    Free PMC article.
Review.
Serum HER2 levels are increased in cats with mammary carcinomas and predict tissue HER2 status.
Maria Soares, Rita Ribeiro, +4 authors, Fernando Ferreira.
Oncotarget, 2016 Feb 26; 7(14). PMID: 26909614    Free PMC article.
Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers.
Bhavna S Paratala, Sonia C Dolfi, +3 authors, Kim M Hirshfield.
Biomark Cancer, 2016 Feb 27; 8(Supple 1). PMID: 26917980    Free PMC article.
Review.
Aberrant Promoter Methylation of the Tumour Suppressor RASSF10 and Its Growth Inhibitory Function in Breast Cancer.
Antje M Richter, Sara K Walesch, Reinhard H Dammann.
Cancers (Basel), 2016 Mar 02; 8(3). PMID: 26927176    Free PMC article.
Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy.
Takayuki Ueno, Shigehira Saji, +13 authors, Masakazu Toi.
BMC Cancer, 2016 Mar 18; 16. PMID: 26984766    Free PMC article.
Tamoxifen Action in ER-Negative Breast Cancer.
Subrata Manna, Marina K Holz.
Sign Transduct Insights, 2016 Mar 19; 5. PMID: 26989346    Free PMC article.
Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis.
Haiping Zhou, Xing Wang, +5 authors, Xue-Ru Wu.
Oncotarget, 2016 Mar 19; 7(17). PMID: 26992222    Free PMC article.
ELL targets c-Myc for proteasomal degradation and suppresses tumour growth.
Yu Chen, Chi Zhou, +9 authors, Wuhan Xiao.
Nat Commun, 2016 Mar 25; 7. PMID: 27009366    Free PMC article.
Comparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinoma.
Yayoi Adachi, Junko Ishiguro, +12 authors, Hiroji Iwata.
BMC Cancer, 2016 Mar 27; 16. PMID: 27015895    Free PMC article.
Evaluation of CCND1 amplification and CyclinD1 expression: diffuse and strong staining of CyclinD1 could have same predictive roles as CCND1 amplification in ER positive breast cancers.
Zhishuang Li, Jingjing Cui, +3 authors, Li Li.
Am J Transl Res, 2016 Apr 14; 8(1). PMID: 27069548    Free PMC article.
Bioluminescence imaging of estrogen receptor activity during breast cancer progression.
Cristina Vantaggiato, Giulia Dell'Omo, +6 authors, Paolo Ciana.
Am J Nucl Med Mol Imaging, 2016 Apr 14; 6(1). PMID: 27069764    Free PMC article.
Differential expression of major histocompatibility complex class I in subtypes of breast cancer is associated with estrogen receptor and interferon signaling.
Hee Jin Lee, In Hye Song, +4 authors, Gyungyub Gong.
Oncotarget, 2016 Apr 29; 7(21). PMID: 27121061    Free PMC article.
A systematic comparison of three commercial estrogen receptor assays in a single clinical outcome breast cancer cohort.
Elizabeth N Kornaga, Alexander C Klimowicz, +4 authors, Anthony M Magliocco.
Mod Pathol, 2016 Apr 30; 29(8). PMID: 27125355
Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer.
Mi Joo Chung, Jong Hoon Lee, +2 authors, Hyun Joo Choi.
Medicine (Baltimore), 2016 May 20; 95(20). PMID: 27196477    Free PMC article.
Estrogen Receptor-Targeted Contrast Agents for Molecular Magnetic Resonance Imaging of Breast Cancer Hormonal Status.
Adi Pais, Hadassa Degani.
Front Oncol, 2016 May 21; 6. PMID: 27200289    Free PMC article.
Assessment of psychosocial factors and distress in women having adjuvant endocrine therapy for breast cancer: the relationship among emotional distress and patient and treatment-related factors.
Ozturk Ates, Cem Soylu, +5 authors, Kadri Altundag.
Springerplus, 2016 May 25; 5. PMID: 27218001    Free PMC article.
GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas.
Toshiaki Haraguchi, Hiroaki Miyoshi, +8 authors, Koichi Ohshima.
PLoS One, 2016 Jun 02; 11(6). PMID: 27249072    Free PMC article.
A Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.
Andres Rojas, Pingyu Zhang, +7 authors, Boris Blechacz.
Neoplasia, 2016 Jun 14; 18(6). PMID: 27292026    Free PMC article.
Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase.
Cheng-Hsun Ho, Huai-Chia Chuang, +9 authors, Ting-Tsung Chang.
Oncotarget, 2016 Jun 28; 7(31). PMID: 27343552    Free PMC article.
Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement.
Elizabeth R Zarrella, Madeline Coulter, +5 authors, Veronique M Neumeister.
Lab Invest, 2016 Jun 28; 96(9). PMID: 27348626    Free PMC article.
Overexpression of Specific CD44 Isoforms Is Associated with Aggressive Cell Features in Acquired Endocrine Resistance.
Rebecca Bellerby, Chris Smith, +6 authors, Stephen Hiscox.
Front Oncol, 2016 Jul 06; 6. PMID: 27379207    Free PMC article.
Non-canonical NF-κB pathway activation predicts outcome in borderline oestrogen receptor positive breast carcinoma.
Federico Rojo, Abel González-Pérez, +15 authors, Pilar Eroles.
Br J Cancer, 2016 Jul 13; 115(3). PMID: 27404455    Free PMC article.
Association between CXCR2 and IL-22BP expression indicate a poor outcome for gastric adenocarcinoma progression.
Shi Bin Yang, Fanghai Han, +2 authors, Wenhua Zhan.
Oncol Lett, 2016 Jul 23; 12(2). PMID: 27446456    Free PMC article.
Influence of delayed initiation of adjuvant chemotherapy on breast cancer survival is subtype-dependent.
Ke-Da Yu, Lei Fan, +3 authors, Zhi-Ming Shao.
Oncotarget, 2016 Jul 23; 8(28). PMID: 27447963    Free PMC article.
Expression of Myxovirus Resistance A (MxA) Is Associated with Tumor-Infiltrating Lymphocytes in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancers.
So Jeong Lee, Cheong-Soo Hwang, +14 authors, Ahrong Kim.
Cancer Res Treat, 2016 Jul 28; 49(2). PMID: 27456948    Free PMC article.
Designer interface peptide grafts target estrogen receptor alpha dimerization.
S Chakraborty, B K Asare, P K Biswas, R V Rajnarayanan.
Biochem Biophys Res Commun, 2016 Jul 28; 478(1). PMID: 27462021    Free PMC article.
Prolactin Pro-Differentiation Pathway in Triple Negative Breast Cancer: Impact on Prognosis and Potential Therapy.
Vanessa M López-Ozuna, Ibrahim Y Hachim, +2 authors, Suhad Ali.
Sci Rep, 2016 Aug 03; 6. PMID: 27480353    Free PMC article.
The Estrogen Receptor α-Cistrome Beyond Breast Cancer.
Marjolein Droog, Mark Mensink, Wilbert Zwart.
Mol Endocrinol, 2016 Aug 05; 30(10). PMID: 27489947    Free PMC article.
Review.
Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium.
William J Howat, Fiona M Blows, +49 authors, Montserrat García-Closas.
J Pathol Clin Res, 2015 Jan 01; 1(1). PMID: 27499890    Free PMC article.
ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors.
Daniel L Hertz, N Lynn Henry, +12 authors, James M Rae.
Physiol Genomics, 2016 Aug 21; 48(9). PMID: 27542969    Free PMC article.
Prognosis of breast cancer molecular subtypes in routine clinical care: A large prospective cohort study.
André Hennigs, Fabian Riedel, +13 authors, Andreas Schneeweiss.
BMC Cancer, 2016 Sep 17; 16(1). PMID: 27634735    Free PMC article.
A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential core biopsies of primary, untreated breast cancer.
Sirwan M Hadad, Lee B Jordan, +5 authors, Alastair M Thompson.
BMC Cancer, 2016 Sep 24; 16(1). PMID: 27658825    Free PMC article.
Trends in Neoadjuvant Endocrine Therapy Use and Impact on Rates of Breast Conservation in Hormone Receptor-Positive Breast Cancer: A National Cancer Data Base Study.
Akiko Chiba, Tanya L Hoskin, +3 authors, Judy C Boughey.
Ann Surg Oncol, 2016 Sep 25; 24(2). PMID: 27663568    Free PMC article.
Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury.
Niteen Tapuria, Sameer Junnarkar, +3 authors, Brian R Davidson.
World J Gastroenterol, 2016 Sep 28; 22(33). PMID: 27672274    Free PMC article.
Inhibition of Complement Retards Ankylosing Spondylitis Progression.
Chaoqun Yang, Peipei Ding, +9 authors, Xuhui Zhou.
Sci Rep, 2016 Oct 05; 6. PMID: 27698377    Free PMC article.
Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen.
Heather M Brechbuhl, Jessica Finlay-Schultz, +9 authors, Peter Kabos.
Clin Cancer Res, 2016 Oct 06; 23(7). PMID: 27702820    Free PMC article.
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.
Xiaoyong Fu, Rinath Jeselsohn, +24 authors, Rachel Schiff.
Proc Natl Acad Sci U S A, 2016 Oct 30; 113(43). PMID: 27791031    Free PMC article.
MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways.
Marick Laé, Sophie Gardrat, +8 authors, Ivan Bièche.
Oncotarget, 2016 Nov 03; 7(51). PMID: 27806318    Free PMC article.
Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells.
Polina Weitzenfeld, Tsipi Meshel, Adit Ben-Baruch.
Oncotarget, 2016 Nov 12; 7(49). PMID: 27835603    Free PMC article.
Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer.
J F Hiken, J I McDonald, +8 authors, J R Edwards.
Oncogene, 2016 Nov 22; 36(16). PMID: 27869171    Free PMC article.
Oestrogen receptor negativity in breast cancer: a cause or consequence?
Vijaya Narasihma Reddy Gajulapalli, Vijaya Lakshmi Malisetty, Suresh Kumar Chitta, Bramanandam Manavathi.
Biosci Rep, 2016 Nov 26; 36(6). PMID: 27884978    Free PMC article.
Review.
Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.
Laurie K Svoboda, Natashay Bailey, +10 authors, Elizabeth R Lawlor.
Oncotarget, 2016 Nov 27; 8(1). PMID: 27888797    Free PMC article.
Recent perspectives of breast cancer prognosis and predictive factors.
Su-Sheng Cao, Cun-Tao Lu.
Oncol Lett, 2016 Dec 03; 12(5). PMID: 27900052    Free PMC article.
Discordance between original and central laboratories in ER and HER2 results in a diverse, population-based sample.
Jennifer J Griggs, Ann S Hamilton, +8 authors, Steven J Katz.
Breast Cancer Res Treat, 2016 Dec 03; 161(2). PMID: 27900490    Free PMC article.
Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
Paul M Wilkerson, Konstantin J Dedes, +10 authors, Jorge S Reis-Filho.
Oncotarget, 2016 Dec 22; 8(4). PMID: 28002809    Free PMC article.
Claudin-Low Breast Cancer; Clinical & Pathological Characteristics.
Kay Dias, Anna Dvorkin-Gheva, +6 authors, Anita L Bane.
PLoS One, 2017 Jan 04; 12(1). PMID: 28045912    Free PMC article.
Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells through the Activation of the MAPK/ERK Pathway.
Damián E Berardi, Diego Raffo, Laura B Todaro, Marina Simian.
Cancer Res Treat, 2017 Jan 06; 49(4). PMID: 28052658    Free PMC article.
Amplification of HER2 and TOP2A and deletion of TOP2A genes in a series of Taiwanese breast cancer.
Jim-Ray Chen, Hui-Ping Chien, +8 authors, Chung-Ching Hua.
Medicine (Baltimore), 2017 Jan 13; 96(2). PMID: 28079792    Free PMC article.
Synaptophysin-Ki67 double stain: a novel technique that improves interobserver agreement in the grading of well-differentiated gastrointestinal neuroendocrine tumors.
Karen Matsukuma, Kristin A Olson, +3 authors, Laurel Beckett.
Mod Pathol, 2017 Jan 14; 30(4). PMID: 28084345    Free PMC article.
A network-based pathway-expanding approach for pathway analysis.
Qiaosheng Zhang, Jie Li, +2 authors, Yadong Wang.
BMC Bioinformatics, 2017 Feb 06; 17(Suppl 17). PMID: 28155638    Free PMC article.
Prognostic Significance of Stromal Versus Intratumoral Infiltrating Lymphocytes in Different Subtypes of Breast Cancer Treated With Cytotoxic Neoadjuvant Chemotherapy.
Thaer Khoury, Vidya Nagrale, +3 authors, Song Yao.
Appl Immunohistochem Mol Morphol, 2017 Feb 12; 26(8). PMID: 28187033    Free PMC article.
Comparison of immunohistochemistry with PCR for assessment of ER, PR, and Ki-67 and prediction of pathological complete response in breast cancer.
Hans-Peter Sinn, Andreas Schneeweiss, +9 authors, Frederik Marmé.
BMC Cancer, 2017 Feb 15; 17(1). PMID: 28193205    Free PMC article.
Discrepancies in central review re-testing of patients with ER-positive and HER2-negative breast cancer in the OPTIMA prelim randomised clinical trial.
S E Pinder, A F Campbell, +7 authors, R C Stein.
Br J Cancer, 2017 Feb 22; 116(7). PMID: 28222072    Free PMC article.
Correlation of Molecular Subtypes of Invasive Ductal Carcinoma of Breast with Glucose Metabolism in FDG PET/CT: Based on the Recommendations of the St. Gallen Consensus Meeting 2013.
Sun Seong Lee, Sang Kyun Bae, +5 authors, Seok Mo Lee.
Nucl Med Mol Imaging, 2017 Mar 03; 51(1). PMID: 28250861    Free PMC article.
Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer.
Graciele C M Manica, Caroline F Ribeiro, +12 authors, Giseli Klassen.
Sci Rep, 2017 Mar 16; 7. PMID: 28294120    Free PMC article.
A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2- early breast cancer.
Gyungyub Gong, Mi Jeong Kwon, +15 authors, Young Kee Shin.
Sci Rep, 2017 Mar 30; 7. PMID: 28350001    Free PMC article.
Estrogen-Related Factors in the Frontal Lobe of Alzheimer's Disease Patients and Importance of Body Mass Index.
Naoko Honma, Shigehira Saji, +5 authors, Nobuhiro Harada.
Sci Rep, 2017 Apr 09; 7(1). PMID: 28389656    Free PMC article.
Comparison of standardized uptake value of 18F-FDG-PET-CT with 21-gene recurrence score in estrogen receptor-positive, HER2-negative breast cancer.
Sung Gwe Ahn, Jae-Hoon Lee, +8 authors, Seung Il Kim.
PLoS One, 2017 Apr 19; 12(4). PMID: 28419166    Free PMC article.
Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER⁺ Breast Cancer Cells.
Nipin Sp, Dong Young Kang, +6 authors, Young Mok Yang.
Int J Mol Sci, 2017 May 05; 18(5). PMID: 28468300    Free PMC article.
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer.
Woosung Chung, Hye Hyeon Eum, +10 authors, Woong-Yang Park.
Nat Commun, 2017 May 06; 8. PMID: 28474673    Free PMC article.
Highly Cited.
Prognostic and predictive value of low estrogen receptor expression in breast cancer.
A Bouchard-Fortier, L Provencher, C Blanchette, C Diorio.
Curr Oncol, 2017 May 12; 24(2). PMID: 28490933    Free PMC article.
Cognitive Effects of Chemotherapy and Cancer-Related Treatments in Older Adults.
Jennifer N Vega, Julie Dumas, Paul A Newhouse.
Am J Geriatr Psychiatry, 2017 May 13; 25(12). PMID: 28495470    Free PMC article.
Review.
High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers.
Cecilia Ahlin, Claudia Lundgren, +3 authors, M -L Fjällskog.
Breast Cancer Res Treat, 2017 May 22; 164(3). PMID: 28528450    Free PMC article.
Power of PgR expression as a prognostic factor for ER-positive/HER2-negative breast cancer patients at intermediate risk classified by the Ki67 labeling index.
Sasagu Kurozumi, Hiroshi Matsumoto, +6 authors, Masafumi Kurosumi.
BMC Cancer, 2017 May 24; 17(1). PMID: 28532429    Free PMC article.
Comparison of HER2 amplification status among breast cancer subgroups offers new insights in pathways of breast cancer progression.
Kathleen Lambein, Mieke Van Bockstal, +5 authors, Louis Libbrecht.
Virchows Arch, 2017 Jun 02; 471(5). PMID: 28567637
A Risk Model based on Ultrasound, Ultrasound Elastography, and Histologic Parameters for Predicting Axillary Lymph Node Metastasis in Breast Invasive Ductal Carcinoma.
Xiao-Long Li, Hui-Xiong Xu, +6 authors, Lin Fang.
Sci Rep, 2017 Jun 10; 7(1). PMID: 28596561    Free PMC article.
Extended adjuvant endocrine therapy in early breast cancer: a meta-analysis of published randomized trials.
Ezzeldin M Ibrahim, Marwan R Al-Hajeili, +2 authors, Ahmed A Refae.
Med Oncol, 2017 Jun 18; 34(7). PMID: 28620883
FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
Jung Wook Park, John K Lee, Owen N Witte, Jiaoti Huang.
Mod Pathol, 2017 Jun 18; 30(9). PMID: 28621319    Free PMC article.
Molecular genetics complexity impeding research progress in breast and ovarian cancers.
Ishita Gupta, Ikram Burney, Mansour S Al-Moundhri, Yahya Tamimi.
Mol Clin Oncol, 2017 Jul 08; 7(1). PMID: 28685067    Free PMC article.
21-Gene recurrence score and locoregional recurrence in lymph node-negative, estrogen receptor-positive breast cancer.
Gulisa Turashvili, Joanne F Chou, +5 authors, Hannah Y Wen.
Breast Cancer Res Treat, 2017 Jul 14; 166(1). PMID: 28702894    Free PMC article.
Dissecting the Biological Heterogeneity within Hormone Receptor Positive HER2 Negative Breast Cancer by Gene Expression Markers Identifies Indolent Tumors within Late Stage Disease.
Jyothi S Prabhu, Aruna Korlimarla, +14 authors, T S Sridhar.
Transl Oncol, 2017 Jul 14; 10(4). PMID: 28704710    Free PMC article.
FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma.
Joshua I Warrick, Matthew Kaag, +6 authors, Guoli Chen.
Virchows Arch, 2017 Jul 20; 471(3). PMID: 28721490
ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma.
A D Marshall, M van Geldermalsen, +10 authors, J Holst.
Oncogenesis, 2017 Aug 02; 6(7). PMID: 28759021    Free PMC article.
Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications.
Seth Winfree, Michael J Ferkowicz, +7 authors, Tarek M El-Achkar.
Transl Res, 2017 Aug 09; 189. PMID: 28784428    Free PMC article.
Review.
Estrogen receptor quantitative measures and breast cancer survival.
Deirdre A Hill, Marc Barry, +4 authors, Lesley Lomo.
Breast Cancer Res Treat, 2017 Aug 22; 166(3). PMID: 28825224    Free PMC article.
Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer.
Yuji Yamashita, Shin Nishiumi, +3 authors, Masaru Yoshida.
BMC Cancer, 2017 Aug 31; 17(1). PMID: 28851309    Free PMC article.
The association between smoking and breast cancer characteristics and outcome.
Hadar Goldvaser, Omer Gal, +6 authors, Rinat Yerushalmi.
BMC Cancer, 2017 Sep 07; 17(1). PMID: 28874120    Free PMC article.
Expression and Prognostic Value of Oestrogen Receptor Beta in Colorectal Cancer.
Elisabeth Pérez-Ruiz, Antonio Rueda, +9 authors, Lorenzo Alonso.
Pathol Oncol Res, 2017 Sep 11; 24(4). PMID: 28889324
Re-Appraisal of Estrogen Receptor Negative/Progesterone Receptor Positive (ER-/PR+) Breast Cancer Phenotype: True Subtype or Technical Artefact?
Niamh M Foley, J M Coll, +5 authors, K J Sweeney.
Pathol Oncol Res, 2017 Sep 12; 24(4). PMID: 28891017
Ki-67 Expression in Breast Cancer Tissue Microarrays: Assessing Tumor Heterogeneity, Concordance With Full Section, and Scoring Methods.
Thaer Khoury, Gary Zirpoli, +9 authors, Christine B Ambrosone.
Am J Clin Pathol, 2017 Sep 14; 148(2). PMID: 28898983    Free PMC article.
Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer.
Ana C Gregório, Manuela Lacerda, +3 authors, João Nuno Moreira.
Pathol Oncol Res, 2017 Sep 16; 24(4). PMID: 28913723
Review.
Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer.
Roberto A Leon-Ferre, Mei-Yin Polley, +15 authors, Matthew P Goetz.
Breast Cancer Res Treat, 2017 Sep 16; 167(1). PMID: 28913760    Free PMC article.
Validation of immunoexpression of tenascin-C in oral precancerous and cancerous tissues using ImageJ analysis with novel immunohistochemistry profiler plugin: An immunohistochemical quantitative analysis.
Deepa Rajesh Mane, Alka D Kale, Chetan Belaldavar.
J Oral Maxillofac Pathol, 2017 Sep 22; 21(2). PMID: 28932029    Free PMC article.
SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1.
Junmei Cairns, James N Ingle, +3 authors, Liewei Wang.
PLoS Genet, 2017 Oct 03; 13(10). PMID: 28968398    Free PMC article.
NanoString nCounter® Approach in Breast Cancer: A Comparative Analysis with Quantitative Real-Time Polymerase Chain Reaction, In Situ Hybridization, and Immunohistochemistry.
Jiyeon Hyeon, Soo Youn Cho, +4 authors, Eun Yoon Cho.
J Breast Cancer, 2017 Oct 04; 20(3). PMID: 28970855    Free PMC article.
Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells.
Trang H Luu, Jean-Marie Bard, +4 authors, Hassan Nazih.
Cell Oncol (Dordr), 2017 Oct 11; 41(1). PMID: 28993998
Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer.
Daniel E Carvajal-Hausdorf, Nikita Mani, +2 authors, David L Rimm.
J Immunother Cancer, 2017 Oct 19; 5(1). PMID: 29037255    Free PMC article.
Comparison of patients with small (≤2 cm) breast cancer according to adherence to breast screening program.
Jung Min Park, Soong Jun Bae, +5 authors, Joon Jeong.
PLoS One, 2017 Nov 03; 12(11). PMID: 29095835    Free PMC article.
Chemosensitivity to doxorubicin of ER-positive/HER2-negative breast cancers with high 21-gene recurrence score: A study based on in vitro chemoresponse assay.
Sung Gwe Ahn, Soong June Bae, +4 authors, Joon Jeong.
PLoS One, 2017 Nov 09; 12(11). PMID: 29117208    Free PMC article.
Molecular Subtypes and Local-Regional Control of Breast Cancer.
Simona Maria Fragomeni, Andrew Sciallis, Jacqueline S Jeruss.
Surg Oncol Clin N Am, 2017 Nov 15; 27(1). PMID: 29132568    Free PMC article.
Review.
A tissue microRNA signature that predicts the prognosis of breast cancer in young women.
Ai Hironaka-Mitsuhashi, Juntaro Matsuzaki, +10 authors, Takahiro Ochiya.
PLoS One, 2017 Nov 16; 12(11). PMID: 29141042    Free PMC article.
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.
Viroj Boonyaratanakornkit, Nalo Hamilton, +3 authors, Richard J Pietras.
Mol Cell Endocrinol, 2017 Nov 18; 466. PMID: 29146555    Free PMC article.
Review.
Amplification of Genomic DNA for Decoy Receptor 3 Predicts Post-Resection Disease Recurrence in Breast Cancer Patients.
Chizuko Kanbayashi, Yu Koyama, +9 authors, Toshifumi Wakai.
World J Oncol, 2014 Feb 01; 5(1). PMID: 29147372    Free PMC article.
Combination of plasma HA and circulating M2-like monocytes may serve as a diagnostic marker for breast cancer.
Boke Zhang, Manlin Cao, +7 authors, Feng Gao.
J Cancer, 2017 Nov 21; 8(17). PMID: 29151937    Free PMC article.
The histone demethylase Kdm3a is required for normal epithelial proliferation, ductal elongation and tumor growth in the mouse mammary gland.
Li Qin, Yixiang Xu, +6 authors, Jianming Xu.
Oncotarget, 2017 Nov 22; 8(49). PMID: 29156681    Free PMC article.
A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.
Philipp Y Maximov, Balkees Abderrahman, +3 authors, V Craig Jordan.
Endocr Relat Cancer, 2017 Nov 23; 25(2). PMID: 29162647    Free PMC article.
Review.
Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis.
Yanming Wu, Zhao Zhang, +17 authors, Kexin Xu.
Cancer Res, 2017 Dec 08; 78(3). PMID: 29212856    Free PMC article.
Clinical and Epidemiological Profile of Breast Cancer in Mexico: Results of the Seguro Popular.
Nancy Reynoso-Noverón, Cynthia Villarreal-Garza, +9 authors, Alejandro Mohar.
J Glob Oncol, 2017 Dec 16; 3(6). PMID: 29244990    Free PMC article.
Protein biomarkers for subtyping breast cancer and implications for future research.
Claudius Mueller, Amanda Haymond, +2 authors, Virginia Espina.
Expert Rev Proteomics, 2017 Dec 23; 15(2). PMID: 29271260    Free PMC article.
Review.
Tumor Heterogeneity in Breast Cancer.
Gulisa Turashvili, Edi Brogi.
Front Med (Lausanne), 2017 Dec 26; 4. PMID: 29276709    Free PMC article.
Highly Cited. Review.
Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.
Vineet K Dhiman, Michael J Bolt, Kevin P White.
Nat Rev Genet, 2017 Dec 28; 19(3). PMID: 29279606
Review.
SUOX is negatively associated with multistep carcinogenesis and proliferation in oral squamous cell carcinoma.
Ken Nakamura, Jun Akiba, +5 authors, Hirohisa Yano.
Med Mol Morphol, 2017 Dec 28; 51(2). PMID: 29280012
Salivary Duct Carcinoma and Invasive Ductal Carcinoma of the Breast: A Comparative Immunohistochemical Study.
Jalal B Jalaly, Souzan Sanati, +2 authors, Samir K El-Mofty.
Head Neck Pathol, 2018 Jan 06; 12(4). PMID: 29302899    Free PMC article.
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Sung-Im Do, Hyun-Soo Kim, +5 authors, Jin Hee Sohn.
Am J Transl Res, 2018 Jan 10; 9(12). PMID: 29312521    Free PMC article.
Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer.
Jun Yang, Adrian L Harris, Andrew M Davidoff.
Int J Mol Sci, 2018 Jan 19; 19(1). PMID: 29342868    Free PMC article.
Review.
Preparation of anastrozole loaded PEG-PLA nanoparticles: evaluation of apoptotic response of breast cancer cell lines.
Yusra A Alyafee, Manal Alaamery, +6 authors, Salam Massadeh.
Int J Nanomedicine, 2018 Jan 19; 13. PMID: 29343958    Free PMC article.
The correlation of background parenchymal enhancement in the contralateral breast with patient and tumor characteristics of MRI-screen detected breast cancers.
Suzan Vreemann, Albert Gubern-Mérida, +3 authors, Ritse M Mann.
PLoS One, 2018 Jan 20; 13(1). PMID: 29351560    Free PMC article.
Knockdown of TBRG4 affects tumorigenesis in human H1299 lung cancer cells by regulating DDIT3, CAV1 and RRM2.
Ansheng Wang, Chengling Zhao, +5 authors, Yuan Gao.
Oncol Lett, 2018 Feb 02; 15(1). PMID: 29387213    Free PMC article.
Barriers to early presentation of breast cancer among women in Soweto, South Africa.
Maureen Joffe, Oluwatosin Ayeni, +6 authors, Herbert Cubasch.
PLoS One, 2018 Feb 03; 13(2). PMID: 29394271    Free PMC article.
Meta-analysis of three genome-wide association studies identifies two loci that predict survival and treatment outcome in breast cancer.
Sofia Khan, Rainer Fagerholm, +6 authors, Heli Nevanlinna.
Oncotarget, 2018 Feb 10; 9(3). PMID: 29423119    Free PMC article.
Multifunctionalized biocatalytic P22 nanoreactor for combinatory treatment of ER+ breast cancer.
Kanchan Chauhan, Juan M Hernandez-Meza, +3 authors, Rafael Vazquez-Duhalt.
J Nanobiotechnology, 2018 Feb 22; 16(1). PMID: 29463260    Free PMC article.
The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma.
Damien Ambrosetti, Maeva Dufies, +8 authors, Nathalie M Mazure.
PLoS One, 2018 Feb 27; 13(2). PMID: 29481555    Free PMC article.
Down-regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer.
Qiongli Su, Ting Tao, +8 authors, Xiaoping Yang.
J Cell Mol Med, 2018 Mar 08; 22(5). PMID: 29512924    Free PMC article.
The role of programmed death ligand-1 and tumor-infiltrating lymphocytes in breast cancer overexpressing HER2 gene.
Yanchun Li, Mateusz Opyrchal, +4 authors, Thaer Khoury.
Breast Cancer Res Treat, 2018 Mar 11; 170(2). PMID: 29524062    Free PMC article.
Exercise Therapy and Cardiovascular Toxicity in Cancer.
Jessica M Scott, Tormod S Nilsen, Dipti Gupta, Lee W Jones.
Circulation, 2018 Mar 14; 137(11). PMID: 29530893    Free PMC article.
Highly Cited. Review.
NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation.
Heather L Lehman, Michal Kidacki, Joshua I Warrick, Douglas B Stairs.
Oncotarget, 2018 Mar 16; 9(13). PMID: 29541406    Free PMC article.
Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer.
Sung Gwe Ahn, Yoon Jin Cha, +3 authors, Joon Jeong.
BMC Cancer, 2018 Mar 27; 18(1). PMID: 29573739    Free PMC article.
Epigenetic Modifications as Biomarkers of Tumor Development, Therapy Response, and Recurrence across the Cancer Care Continuum.
Margaret L Thomas, Paola Marcato.
Cancers (Basel), 2018 Apr 05; 10(4). PMID: 29614786    Free PMC article.
Review.
The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer.
Jing-Wei Wang, Xiao-Long Wei, +3 authors, Guo-Jun Zhang.
Oncol Lett, 2018 May 29; 15(6). PMID: 29805613    Free PMC article.
Obesity as risk factor for subtypes of breast cancer: results from a prospective cohort study.
Cina J Nattenmüller, Mark Kriegsmann, +13 authors, Tilman Kühn.
BMC Cancer, 2018 Jun 02; 18(1). PMID: 29855282    Free PMC article.
Identifying an early treatment window for predicting breast cancer response to neoadjuvant chemotherapy using immunohistopathology and hemoglobin parameters.
Quing Zhu, Susan Tannenbaum, +10 authors, Kert Sabbath.
Breast Cancer Res, 2018 Jun 15; 20(1). PMID: 29898762    Free PMC article.
Neoadjuvant endocrine therapy with exemestane followed by response-guided combination therapy with low-dose cyclophosphamide in postmenopausal patients with estrogen receptor-positive breast cancer: A multicenter, open-label, phase II study.
Nobuaki Sato, Norikazu Masuda, +9 authors, Masakazu Toi.
Cancer Med, 2018 Jun 16;. PMID: 29905023    Free PMC article.
Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.
Darren K Patten, Giacomo Corleone, +17 authors, Luca Magnani.
Nat Med, 2018 Jul 25; 24(9). PMID: 30038216    Free PMC article.
Microfluidic on-chip immunohistochemistry directly from a paraffin-embedded section.
Chang Hyun Cho, Seyong Kwon, +4 authors, Je-Kyun Park.
Biomicrofluidics, 2018 Aug 07; 12(4). PMID: 30079122    Free PMC article.
Immunohistochemical differentiation between chronic enteropathy associated with SLCO2A1 gene and other inflammatory bowel diseases.
Satoko Yamaguchi, Shunichi Yanai, +7 authors, Takayuki Matsumoto.
Intest Res, 2018 Aug 10; 16(3). PMID: 30090038    Free PMC article.
CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair.
Yuzhen Zhou, Li Chu, +15 authors, Weiguo Hu.
Cell Death Dis, 2018 Sep 01; 9(9). PMID: 30166523    Free PMC article.
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Pin Gao, Xiang Wang, +12 authors, Qing Robert Miao.
Breast Cancer Res, 2018 Sep 14; 20(1). PMID: 30208932    Free PMC article.
Aberrant promoter methylation of PCDH10 as a potential diagnostic and prognostic biomarker for patients with breast cancer.
Wentao Liu, Jin Wu, +3 authors, Qingyuan Zhang.
Oncol Lett, 2018 Sep 15; 16(4). PMID: 30214581    Free PMC article.
Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue.
Hironobu Yamashita, Lauren Shuman, +2 authors, David J Degraff.
Am J Clin Exp Urol, 2018 Sep 25; 6(4). PMID: 30246052    Free PMC article.
IL-1 induces p62/SQSTM1 and autophagy in ERα+ /PR+ BCa cell lines concomitant with ERα and PR repression, conferring an ERα- /PR- BCa-like phenotype.
Afshan Fathima Nawas, Ragini Mistry, +6 authors, Nikki Ayanna Delk.
J Cell Biochem, 2018 Oct 17;. PMID: 30324661    Free PMC article.
Expression of the CD59 Glycoprotein Precursor is Upregulated in an Estrogen Receptor-alpha (ER-α)-Negative and a Tamoxifen-Resistant Breast Cancer Cell Line In Vitro.
Huiru Xiong, Xiaowei Jin, Chuanwen You.
Med Sci Monit, 2018 Nov 06; 24. PMID: 30391994    Free PMC article.
Risk factors for the development of brain metastases in patients with HER2-positive breast cancer.
Christian Maurer, Lorraine Tulpin, +6 authors, Ahmad Awada.
ESMO Open, 2018 Nov 15; 3(6). PMID: 30425844    Free PMC article.
Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.
Mam Y Mboge, Zhijuan Chen, +8 authors, Susan C Frost.
PLoS One, 2018 Nov 20; 13(11). PMID: 30452451    Free PMC article.
BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer.
Mi Jeong Kwon, Sae Byul Lee, +8 authors, Young Kee Shin.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462685    Free PMC article.
Correlation of Serum Levels of Urokinase Activation Plasminogen (uPA) and Its Inhibitor (PAI-1) with Hormonal and HER-2 Status in the Early Invasive Breast Cancer.
Sadat Pusina.
Med Arch, 2018 Dec 14; 72(5). PMID: 30524164    Free PMC article.
FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor-Positive (HR+) Breast Cancer.
Joshua Z Drago, Luigi Formisano, +16 authors, Aditya Bardia.
Clin Cancer Res, 2019 Aug 03; 25(21). PMID: 31371343    Free PMC article.
Variability of predictive markers (hormone receptors, Her2, Ki67) and intrinsic subtypes of breast cancer in four consecutive years 2015-2018.
Lidija Stevanovic, Matthias Choschzick, Linda Moskovszky, Zsuzsanna Varga.
J Cancer Res Clin Oncol, 2019 Oct 20; 145(12). PMID: 31628534    Free PMC article.
Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression.
Louis Allott, Cecilia Miranda, +3 authors, Graham Smith.
EJNMMI Radiopharm Chem, 2019 Oct 30; 4(1). PMID: 31659497    Free PMC article.
Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer.
Hironobu Yamashita, Yuka I Kawasawa, +10 authors, David J DeGraff.
Oncogenesis, 2019 Nov 28; 8(12). PMID: 31772149    Free PMC article.
Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer.
Annika Jögi, Anna Ehinger, Linda Hartman, Sara Alkner.
PLoS One, 2019 Dec 11; 14(12). PMID: 31821370    Free PMC article.
Clinical characteristics and prognostic analysis of ipsilateral supraclavicular lymph node metastases in breast cancer patients: a retrospective study.
Rui Jin, Xiaochi Hu, Jingtao Luo.
Int J Clin Exp Pathol, 2020 Jan 15; 12(9). PMID: 31934200    Free PMC article.
Low nuclear zinc finger and BTB domain containing 7A expression is an independent prognostic factor for recurrence-free survival in invasive ductal carcinoma of the breast.
Yuil Kim, Hyun-Soo Kim, Sung-Im Do.
Int J Clin Exp Pathol, 2018 Apr 01; 11(4). PMID: 31938331    Free PMC article.
Clinicopathologic significance of androgen receptor expression and discordant receptor status during progression in breast cancer.
Eun Young Kim, Kwan Ho Lee, +4 authors, Seoung Wan Chae.
Int J Clin Exp Pathol, 2017 Jul 01; 10(7). PMID: 31966643    Free PMC article.
Expression of PGRMC1 in paraffin-embedded tissues of breast cancer.
Ying Zhang, Xiangyan Ruan, Xin Mi, Alfred O Mueck.
Int J Clin Exp Pathol, 2017 Sep 01; 10(9). PMID: 31966843    Free PMC article.
Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention.
Coral Omene, Lin Ma, +10 authors, Mary Helen Barcellos-Hoff.
Cancer Immunol Res, 2019 Dec 14; 8(2). PMID: 31831632    Free PMC article.
Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications.
Emma H Allott, Yue Shan, +11 authors, Melissa A Troester.
Breast Cancer Res Treat, 2019 Sep 20; 179(1). PMID: 31535320    Free PMC article.
Clinicopathological Characteristics and Breast Cancer-Specific Survival of Patients With Single Hormone Receptor-Positive Breast Cancer.
Yunhai Li, Dejuan Yang, +8 authors, Guosheng Ren.
JAMA Netw Open, 2020 Jan 04; 3(1). PMID: 31899528    Free PMC article.
Association between low estrogen receptor positive breast cancer and staining performance.
Dennis Caruana, Wei Wei, +2 authors, Emily S Reisenbichler.
NPJ Breast Cancer, 2020 Feb 13; 6. PMID: 32047851    Free PMC article.
Retained or altered expression of major histocompatibility complex class I in patient-derived xenograft models in breast cancer.
In Hye Song, Young-Ae Kim, +6 authors, Hee Jin Lee.
Immunol Res, 2020 Jan 05; 67(6). PMID: 31900802
Morphological and immunohistochemical characterization of spontaneous endometriosis in rhesus macaques (Macaca mulatta).
Eva Gruber-Dujardin, Martina Bleyer, Kerstin Mätz-Rensing.
Primate Biol, 2017 Apr 13; 4(1). PMID: 32110695    Free PMC article.
2008 update of the guideline: early detection of breast cancer in Germany.
Ute-Susann Albert, Helmut Altland, +18 authors, Ina Kopp.
J Cancer Res Clin Oncol, 2008 Jul 29; 135(3). PMID: 18661152
A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles.
Li Wang, Robert P Sebra, +8 authors, Jun Zhu.
Genome Med, 2020 Mar 01; 12(1). PMID: 32111252    Free PMC article.
Prognostic Value of Skeletal Muscle Depletion Measured on Computed Tomography for Overall Survival in Patients with Non-Metastatic Breast Cancer.
Jimi Huh, Bumhee Park, +6 authors, Tae Hee Kim.
J Breast Cancer, 2020 Mar 07; 23(1). PMID: 32140272    Free PMC article.
Cell cycle-dependent force transmission in cancer cells.
Magdalini Panagiotakopoulou, Tobias Lendenmann, +4 authors, Aldo Ferrari.
Mol Biol Cell, 2018 Aug 17; 29(21). PMID: 30113874    Free PMC article.
Immunohistochemical analysis of estrogen receptor in breast cancer with ESR1 mutations detected by hybrid capture-based next-generation sequencing.
Dara S Ross, Ahmet Zehir, +9 authors, Hannah Y Wen.
Mod Pathol, 2018 Aug 31; 32(1). PMID: 30158597    Free PMC article.
Low PR in ER(+)/HER2(-) breast cancer: high rates of TP53 mutation and high SUV.
Sung Gwe Ahn, Chang Ik Yoon, +7 authors, Joon Jeong.
Endocr Relat Cancer, 2018 Nov 09; 26(2). PMID: 30407916    Free PMC article.
In Silico Approach for Immunohistochemical Evaluation of a Cytoplasmic Marker in Breast Cancer.
Claudia Mazo, Estibaliz Orue-Etxebarria, +3 authors, Andoni Beristain.
Cancers (Basel), 2018 Dec 19; 10(12). PMID: 30558303    Free PMC article.
Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications.
Nishant Gandhi, Gokul M Das.
Cells, 2019 Jan 30; 8(2). PMID: 30691108    Free PMC article.
Highly Cited. Review.
Clinicopathologic Characteristics and Treatment Outcomes of Patients With Up-Front Metastatic Breast Cancer: Single-Center Experience in India.
Ajay Gogia, Suryanarayana Vishnu S Deo, +4 authors, Sandeep Mathur.
J Glob Oncol, 2019 Mar 30; 5. PMID: 30925067    Free PMC article.
Discordance in Biomarker Expression in Breast Cancer After Metastasis: Single Center Experience in India.
Ajay Gogia, S V Suryanarayana Deo, +4 authors, Sandeep Mathur.
J Glob Oncol, 2019 Apr 06; 5. PMID: 30951390    Free PMC article.
The COOH-Terminal Proline-Rich Region of GRP78 Is a Key Regulator of Its Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells.
Chun-Chih Tseng, Pu Zhang, Amy S Lee.
Neoplasia, 2019 Jul 16; 21(8). PMID: 31306849    Free PMC article.
Analysis of correlation-based biomolecular networks from different omics data by fitting stochastic block models.
Katharina Baum, Jagath C Rajapakse, Francisco Azuaje.
F1000Res, 2019 Oct 01; 8. PMID: 31559017    Free PMC article.
Metabolic Pathway Analysis and Effectiveness of Tamoxifen in Danish Breast Cancer Patients.
Thomas P Ahern, Lindsay J Collin, +16 authors, Deirdre Cronin-Fenton.
Cancer Epidemiol Biomarkers Prev, 2020 Jan 15; 29(3). PMID: 31932415    Free PMC article.
Jumonji domain-containing protein 6 protein and its role in cancer.
Jing Yang, Siyuan Chen, +5 authors, Xiawei Wei.
Cell Prolif, 2020 Jan 22; 53(2). PMID: 31961032    Free PMC article.
Review.
The transcription factor CUX1 negatively regulates invasion in castrate resistant prostate cancer.
Emma R Dorris, Amanda O'Neill, +4 authors, R William Watson.
Oncotarget, 2020 Mar 18; 11(9). PMID: 32180898    Free PMC article.
Single-cell RNA sequencing reveals a heterogeneous response to Glucocorticoids in breast cancer cells.
Jackson A Hoffman, Brian N Papas, Kevin W Trotter, Trevor K Archer.
Commun Biol, 2020 Mar 15; 3(1). PMID: 32170217    Free PMC article.
The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma.
Tanjina Kader, Kenneth Elder, +15 authors, Kylie L Gorringe.
NPJ Breast Cancer, 2020 Mar 21; 6. PMID: 32195332    Free PMC article.
Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study).
Kate Packwood, Guy Martland, +12 authors, Diana M Eccles.
J Pathol Clin Res, 2019 May 02; 5(3). PMID: 31041842    Free PMC article.
Quality of life and psychological functioning in postmenopausal women undergoing aromatase inhibitor treatment for early breast cancer.
Gabriella Martino, Antonino Catalano, +6 authors, Ulla Feldt-Rasmussen.
PLoS One, 2020 Mar 28; 15(3). PMID: 32214378    Free PMC article.
Association between Lymph Node Status and Expression Levels of Androgen Receptor, miR-185, miR-205, and miR-21 in Breast Cancer Subtypes.
Tatiana S Kalinina, Vladislav V Kononchuk, +3 authors, Lyudmila F Gulyaeva.
Int J Breast Cancer, 2020 May 07; 2020. PMID: 32373367    Free PMC article.
Distribution and Prognostic Significance of Estrogen Receptor α (ERα), Estrogen Receptor β (ERβ), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma.
Anjali Mishra, Niraj Kumari, +4 authors, Saroj Kanta Mishra.
J Thyroid Res, 2020 May 20; 2020. PMID: 32426104    Free PMC article.
Association of Estrogen Receptor Alpha Expression With Survival in Oropharyngeal Cancer Following Chemoradiation Therapy.
Maria B Koenigs, Armida Lefranc-Torres, +14 authors, James W Rocco.
J Natl Cancer Inst, 2019 Feb 05; 111(9). PMID: 30715409    Free PMC article.
Artificial Intelligence Algorithms to Assess Hormonal Status From Tissue Microarrays in Patients With Breast Cancer.
Gil Shamai, Yoav Binenbaum, +3 authors, Ron Kimmel.
JAMA Netw Open, 2019 Jul 28; 2(7). PMID: 31348505    Free PMC article.
microRNA-Dependent Modulation of Genes Contributes to ESR1's Effect on ERα Positive Breast Cancer.
Shan Gao, Bisha Ding, Weiyang Lou.
Front Oncol, 2020 Jun 06; 10. PMID: 32500028    Free PMC article.
RNA Sequencing in Comparison to Immunohistochemistry for Measuring Cancer Biomarkers in Breast Cancer and Lung Cancer Specimens.
Maxim Sorokin, Kirill Ignatev, +8 authors, Anton Buzdin.
Biomedicines, 2020 May 14; 8(5). PMID: 32397474    Free PMC article.
Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer.
Cuige Zhu, Anna Rogers, +10 authors, Jieya Shao.
Cell Rep, 2020 Jun 11; 31(10). PMID: 32521270    Free PMC article.
Development of a Novel Tool for the Retrieval and Analysis of Hormone Receptor Expression Characteristics in Metastatic Breast Cancer via Data Mining on Pathology Reports.
Kai-Po Chang, John Wang, Chi-Chang Chang, Yen-Wei Chu.
Biomed Res Int, 2020 Jun 23; 2020. PMID: 32566676    Free PMC article.
Prognostic value of the Residual Cancer Burden index according to breast cancer subtype: Validation on a cohort of BC patients treated by neoadjuvant chemotherapy.
Anne-Sophie Hamy, Lauren Darrigues, +13 authors, Fabien Reyal.
PLoS One, 2020 Jun 25; 15(6). PMID: 32579551    Free PMC article.
Breast Cancer: Lifestyle, the Human Gut Microbiota/Microbiome, and Survivorship.
Balazs I Bodai, Therese E Nakata.
Perm J, 2020 Jun 27; 24. PMID: 32589577    Free PMC article.
Borderline Estrogen Receptor-Positive Breast Cancers in Black and White Women.
Halei C Benefield, Emma H Allott, +6 authors, Melissa A Troester.
J Natl Cancer Inst, 2019 Nov 20; 112(7). PMID: 31742342    Free PMC article.
Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.
Divya Bafna, Fuqiang Ban, +2 authors, Artem Cherkasov.
Int J Mol Sci, 2020 Jun 18; 21(12). PMID: 32545494    Free PMC article.
Review.
Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1.
David K Lung, Rebecca M Reese, Elaine T Alarid.
Horm Cancer, 2020 Jun 28; 11(3-4). PMID: 32592004    Free PMC article.
Review.
Associations between absolute neutrophil count and lymphocyte-predominant breast cancer.
Chang Ik Yoon, Soeun Park, +6 authors, Joon Jeong.
Breast, 2019 Oct 15; 50. PMID: 31607527    Free PMC article.
Invasive breast cancer over four decades reveals persisting poor metastatic outcomes in treatment resistant subgroup - the "ATRESS" phenomenon.
Patriek Jurrius, Thomas Green, +9 authors, Arnie Purushotham.
Breast, 2020 Jan 26; 50. PMID: 31981910    Free PMC article.
Prognostic value of neutrophil-to-lymphocyte ratio in human epidermal growth factor receptor 2-negative breast cancer patients who received neoadjuvant chemotherapy.
Soong June Bae, Yoon Jin Cha, +10 authors, Joon Jeong.
Sci Rep, 2020 Aug 06; 10(1). PMID: 32753659    Free PMC article.
Compensatory Estrogen Signal Is Capable of DNA Repair in Antiestrogen-Responsive Cancer Cells via Activating Mutations.
Zsuzsanna Suba.
J Oncol, 2020 Aug 11; 2020. PMID: 32774370    Free PMC article.
Review.
The quest for improving the management of breast cancer by functional imaging: The discovery and development of 16α-[18F]fluoroestradiol (FES), a PET radiotracer for the estrogen receptor, a historical review.
John A Katzenellenbogen.
Nucl Med Biol, 2020 Apr 02; 92. PMID: 32229068    Free PMC article.
Review.
Radiotherapy-Induced High Neutrophil-to-Lymphocyte Ratio is a Negative Prognostic Factor in Patients with Breast Cancer.
Chang Ik Yoon, Dooreh Kim, +8 authors, Joon Jeong.
Cancers (Basel), 2020 Jul 18; 12(7). PMID: 32674376    Free PMC article.
PET Imaging Agents (FES, FFNP, and FDHT) for Estrogen, Androgen, and Progesterone Receptors to Improve Management of Breast and Prostate Cancers by Functional Imaging.
John A Katzenellenbogen.
Cancers (Basel), 2020 Jul 29; 12(8). PMID: 32718075    Free PMC article.
Review.
Lgr5 and stem/progenitor gene expression in gastric/gastroesophageal junction carcinoma - significance of potentially retained stemness.
Ju-Yoon Yoon, Christine Brezden-Masley, Catherine J Streutker.
BMC Cancer, 2020 Sep 08; 20(1). PMID: 32894084    Free PMC article.
Analysis of Hormone Receptor Status in Primary and Recurrent Breast Cancer Via Data Mining Pathology Reports.
Kai-Po Chang, Yen-Wei Chu, John Wang.
Open Med (Wars), 2019 Mar 09; 14. PMID: 30847396    Free PMC article.
ESR1 alterations and metastasis in estrogen receptor positive breast cancer.
Jonathan T Lei, Xuxu Gou, Sinem Seker, Matthew J Ellis.
J Cancer Metastasis Treat, 2019 May 21; 5. PMID: 31106278    Free PMC article.
Ramipril significantly attenuates the development of non-alcoholic steatohepatitis in hyperlipidaemic rabbits.
Mario Claudio Soares Sturzeneker, Lucia de Noronha, +2 authors, Dalton Bertolim Precoma.
Am J Cardiovasc Dis, 2019 May 28; 9(2). PMID: 31131153    Free PMC article.
The Central Contributions of Breast Cancer Stem Cells in Developing Resistance to Endocrine Therapy in Estrogen Receptor (ER)-Positive Breast Cancer.
David Rodriguez, Marc Ramkairsingh, +3 authors, Damu Tang.
Cancers (Basel), 2019 Jul 25; 11(7). PMID: 31336602    Free PMC article.
Review.
Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer.
Mi Jeong Kwon, Jeong Eon Lee, +12 authors, Young Kee Shin.
Front Oncol, 2019 Aug 14; 9. PMID: 31404265    Free PMC article.
Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5.
Mihir A Gudi, Chung Y Yi, Mahrokh Nohadani.
Iran J Pathol, 2019 Sep 19; 14(2). PMID: 31528167    Free PMC article.
The role of cyclin D1 and Ki-67 in the development and prognostication of thin melanoma.
Corina Kaufmann, Werner Kempf, +8 authors, Peter Koelblinger.
Histopathology, 2020 May 07; 77(3). PMID: 32374893    Free PMC article.
No Impact of Smoking Status on Breast Cancer Tumor Infiltrating Lymphocytes, Response to Neoadjuvant Chemotherapy and Prognosis.
Vanille Simon, Lucie Laot, +14 authors, Anne-Sophie Hamy.
Cancers (Basel), 2020 Oct 16; 12(10). PMID: 33053866    Free PMC article.
An H3K4me3 reader, BAP18 as an adaptor of COMPASS-like core subunits co-activates ERα action and associates with the sensitivity of antiestrogen in breast cancer.
Ge Sun, Chunyu Wang, +12 authors, Yue Zhao.
Nucleic Acids Res, 2020 Sep 29; 48(19). PMID: 32986841    Free PMC article.
Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells.
Megumi Funakoshi-Tago, Kenji Tago, +2 authors, Hiroomi Tamura.
Sci Rep, 2020 Nov 13; 10(1). PMID: 33177647    Free PMC article.
Progesterone receptor downregulates breast cancer resistance protein expression via binding to the progesterone response element in breast cancer.
Xiaojuan Wu, Xiaofang Zhang, +7 authors, Gengyin Zhou.
Cancer Sci, 2012 Feb 22; 103(5). PMID: 22348324    Free PMC article.
VEGF-A Is Associated With the Degree of TILs and PD-L1 Expression in Primary Breast Cancer.
Takaaki Fujii, Tomoko Hirakata, +6 authors, Ken Shirabe.
In Vivo, 2020 Sep 03; 34(5). PMID: 32871794    Free PMC article.
Pathological complete response to neoadjuvant trastuzumab and pertuzumab therapy is related to human epidermal growth factor receptor 2 (HER2) amplification level in HER2-amplified breast cancer.
Jin Hyuk Choi, Chang Wan Jeon, Young Ok Kim, Sungui Jung.
Medicine (Baltimore), 2020 Nov 13; 99(46). PMID: 33181670    Free PMC article.
Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition.
Isabelle Romieu, Chiara Scoccianti, +44 authors, Elio Riboli.
Int J Cancer, 2015 Feb 14; 137(8). PMID: 25677034    Free PMC article.
Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas.
Ana Paula Percicote, Gabriel Lazaretti Mardegan, +4 authors, Lúcia de Noronha.
Diagn Pathol, 2018 Jan 31; 13(1). PMID: 29378601    Free PMC article.
The prognostic significance of estrogen and progesterone receptors in grade I and II endometrioid endometrial adenocarcinoma: hormone receptors in risk stratification.
Jun Guan, Liying Xie, +4 authors, Xiaojun Chen.
J Gynecol Oncol, 2018 Nov 28; 30(1). PMID: 30479097    Free PMC article.
Potential protein markers for breast cancer recurrence: a retrospective cohort study.
Chunyan He, Rina Plattner, +6 authors, Thomas C Tucker.
Cancer Causes Control, 2018 Nov 30; 30(1). PMID: 30488343    Free PMC article.
Outcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy.
Elaine M Walsh, Aliaa Shalaby, +6 authors, Grace M Callagy.
Breast Cancer Res Treat, 2018 Nov 30; 174(1). PMID: 30488345    Free PMC article.
Expression of estrogen receptor beta isoforms in pancreatic adenocarcinoma.
Mamoun Younes, Charles J Ly, +3 authors, Jennifer M Bailey.
Oncotarget, 2019 Feb 01; 9(102). PMID: 30701026    Free PMC article.
Alterations in global DNA methylation and metabolism-related genes caused by zearalenone in MCF7 and MCF10F cells.
Ecem Fatma Karaman, Sibel Ozden.
Mycotoxin Res, 2019 Apr 07; 35(3). PMID: 30953299
DNA Methylation Profiles and Their Diagnostic Utility in BC.
Ming Shan, Lei Zhang, +5 authors, Guoqiang Zhang.
Dis Markers, 2019 Jun 15; 2019. PMID: 31198475    Free PMC article.
Assessment of breast cancer immunohistochemistry and tumor characteristics in Nigeria.
Usman Malami Aliyu, Abdulrahaman Auwal Musa.
World J Clin Oncol, 2020 Dec 15; 11(11). PMID: 33312887    Free PMC article.
Genetic variants in NKG2D axis and susceptibility to Epstein-Barr virus-induced nasopharyngeal carcinoma.
Nguyen Hoang Viet, Nguyen Quang Trung, +2 authors, J Luis Espinoza.
J Cancer Res Clin Oncol, 2021 Jan 05; 147(3). PMID: 33392659
Racial differences in estrogen receptor staining levels and implications for treatment and survival among estrogen receptor positive, HER2-negative invasive breast cancers.
Kristen S Purrington, David Gorski, +5 authors, Manohar Ratnam.
Breast Cancer Res Treat, 2020 Apr 03; 181(1). PMID: 32236827
Prognostic and predictive parameters in breast pathology: a pathologist's primer.
Kimberly H Allison.
Mod Pathol, 2020 Nov 07; 34(Suppl 1). PMID: 33154551
The Prognostic Value of Lymph Node Involvement after Neoadjuvant Chemotherapy Is Different among Breast Cancer Subtypes.
Lucie Laot, Enora Laas, +12 authors, Anne-Sophie Hamy.
Cancers (Basel), 2021 Jan 10; 13(2). PMID: 33418983    Free PMC article.
The Presence of an In Situ Component on Pre-Treatment Biopsy Is Not Associated with Response to Neoadjuvant Chemotherapy for Breast Cancer.
Julie Labrosse, Charlotte Morel, +6 authors, Anne-Sophie Hamy.
Cancers (Basel), 2021 Jan 14; 13(2). PMID: 33435265    Free PMC article.
Standardized pathology report for breast cancer.
Soo Youn Cho, So Yeon Park, +10 authors, Hye Kyoung Yoon.
J Pathol Transl Med, 2021 Jan 20; 55(1). PMID: 33461287    Free PMC article.
Review.
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling.
Chengqin Wang, Runze Zhang, +7 authors, Yujun Li.
Front Oncol, 2021 Feb 06; 10. PMID: 33542902    Free PMC article.
Concordance between results of inexpensive statistical models and multigene signatures in patients with ER+/HER2- early breast cancer.
Laurence Slembrouck, Isabelle Vanden Bempt, +12 authors, Giuseppe Floris.
Mod Pathol, 2021 Feb 10;. PMID: 33558657

;. PMID: 33574298
Percentage of Hormone Receptor Positivity in Breast Cancer Provides Prognostic Value: A Single-Institute Study.
Richard Sleightholm, Beth K Neilsen, +10 authors, Michael Baine.
J Clin Med Res, 2021 Feb 23; 13(1). PMID: 33613796    Free PMC article.