Journal Article
. 1999 Jun; 5(6):677-85.
doi: 10.1038/9525.

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

P P Lee 1 C Yee  P A Savage  L Fong  D Brockstedt  J S Weber  D Johnson  S Swetter  J Thompson  P D Greenberg  M Roederer  M M Davis  
Affiliations
  • PMID: 10371507
  •     286 citations

Abstract

We identified circulating CD8+ T-cell populations specific for the tumor-associated antigens (TAAs) MART-1 (27-35) or tyrosinase (368-376) in six of eleven patients with metastatic melanoma using peptide/HLA-A*0201 tetramers. These TAA-specific populations were of two phenotypically distinct types: one, typical for memory/effector T cells; the other, a previously undescribed phenotype expressing both naive and effector cell markers. This latter type represented more than 2% of the total CD8+ T cells in one patient, permitting detailed phenotypic and functional analysis. Although these cells have many of the hallmarks of effector T cells, they were functionally unresponsive, unable to directly lyse melanoma target cells or produce cytokines in response to mitogens. In contrast, CD8+ T cells from the same patient were able to lyse EBV-pulsed target cells and showed robust allogeneic responses. Thus, the clonally expanded TAA-specific population seems to have been selectively rendered anergic in vivo. Peptide stimulation of the TAA-specific T-cell populations in other patients failed to induce substantial upregulation of CD69 expression, indicating that these cells may also have functional defects, leading to blunted activation responses. These data demonstrate that systemic TAA-specific T-cell responses can develop de novo in cancer patients, but that antigen-specific unresponsiveness may explain why such cells are unable to control tumor growth.

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Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma.
Ryo Ueda, Keri L Low, +5 authors, Hideho Okada.
J Transl Med, 2007 Dec 21; 5. PMID: 18093336    Free PMC article.
A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10 -1082 promoter genotype as predictor of disease progression.
Erika M von Euw, María M Barrio, +10 authors, José Mordoh.
J Transl Med, 2008 Jan 29; 6. PMID: 18221542    Free PMC article.
Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.
Nicolas P Andrews, Christopher D Pack, Aron E Lukacher.
J Virol, 2008 Mar 14; 82(10). PMID: 18337581    Free PMC article.
Signaling defects in anti-tumor T cells.
Alan B Frey, Ngozi Monu.
Immunol Rev, 2008 Mar 28; 222. PMID: 18364003    Free PMC article.
Review.
Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors.
Andrea Worschech, Maciej Kmieciak, +5 authors, Masoud H Manjili.
Cancer Res, 2008 Apr 03; 68(7). PMID: 18381452    Free PMC article.
Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies.
Malka Epel, Irit Carmi, +5 authors, Yoram Reiter.
Eur J Immunol, 2008 May 01; 38(6). PMID: 18446790    Free PMC article.
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers.
Africa Wallace, Veena Kapoor, +7 authors, Steven M Albelda.
Clin Cancer Res, 2008 Jun 19; 14(12). PMID: 18559619    Free PMC article.
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Gerald Willimsky, Melinda Czéh, +5 authors, Thomas Blankenstein.
J Exp Med, 2008 Jun 25; 205(7). PMID: 18573907    Free PMC article.
Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.
J Joseph Melenhorst, Phillip Scheinberg, +12 authors, David A Price.
J Immunol Methods, 2008 Aug 05; 338(1-2). PMID: 18675271    Free PMC article.
Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.
Ailin Bai, Eileen Higham, +2 authors, Jianzhu Chen.
Proc Natl Acad Sci U S A, 2008 Aug 30; 105(35). PMID: 18723683    Free PMC article.
Label-free electronic detection of the antigen-specific T-cell immune response.
Eric Stern, Erin R Steenblock, Mark A Reed, Tarek M Fahmy.
Nano Lett, 2008 Sep 04; 8(10). PMID: 18763834    Free PMC article.
Post-transplant adoptive T-cell immunotherapy.
Nicole A Aqui, Carl H June.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790452    Free PMC article.
Review.
Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers.
Pratip K Chattopadhyay, J Joseph Melenhorst, +7 authors, David A Price.
Cytometry A, 2008 Oct 07; 73(11). PMID: 18836993    Free PMC article.
Review.
Targeting minor histocompatibility antigens in graft versus tumor or graft versus leukemia responses.
Xin Feng, Kwok Min Hui, Hashem M Younes, Anthony G Brickner.
Trends Immunol, 2008 Oct 28; 29(12). PMID: 18952501    Free PMC article.
Review.
Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia.
Katayoun Rezvani, Agnes S M Yong, +8 authors, A John Barrett.
Blood, 2008 Nov 08; 113(10). PMID: 18988867    Free PMC article.
Behavior of immune players in the tumor microenvironment.
Mikael J Pittet.
Curr Opin Oncol, 2009 Jan 07; 21(1). PMID: 19125019    Free PMC article.
Review.
Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection.
Joseph N Blattman, E John Wherry, +2 authors, Rafi Ahmed.
J Virol, 2009 Feb 13; 83(9). PMID: 19211743    Free PMC article.
Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation.
Ian Horkheimer, Michael Quigley, +3 authors, Yiping Yang.
Blood, 2009 Mar 13; 113(21). PMID: 19279333    Free PMC article.
Predicting and controlling the reactivity of immune cell populations against cancer.
Kfir Oved, Eran Eden, +11 authors, Yoram Reiter.
Mol Syst Biol, 2009 Apr 30; 5. PMID: 19401677    Free PMC article.
Costimulatory and coinhibitory receptors in anti-tumor immunity.
Gregory Driessens, Justin Kline, Thomas F Gajewski.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426219    Free PMC article.
Review.
Impaired interferon signaling is a common immune defect in human cancer.
Rebecca J Critchley-Thorne, Diana L Simons, +9 authors, Peter P Lee.
Proc Natl Acad Sci U S A, 2009 May 20; 106(22). PMID: 19451644    Free PMC article.
Highly Cited.
Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology.
Hideaki Tahara, Marimo Sato, +53 authors, Francesco M Marincola.
J Transl Med, 2009 Jun 19; 7. PMID: 19534815    Free PMC article.
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells.
Wenshi Wang, Roy Lau, +3 authors, Jeffrey Weber.
Int Immunol, 2009 Aug 05; 21(9). PMID: 19651643    Free PMC article.
Highly Cited.
Betting on immunotherapy for melanoma.
Mario Sznol.
Curr Oncol Rep, 2009 Aug 15; 11(5). PMID: 19679015
Review.
Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma.
Antoni Ribas, Begoña Comin-Anduix, +15 authors, Jesus Gomez-Navarro.
Clin Cancer Res, 2009 Oct 01; 15(19). PMID: 19789309    Free PMC article.
Antitumor immunity and cancer stem cells.
Tobias Schatton, Markus H Frank.
Ann N Y Acad Sci, 2009 Oct 03; 1176. PMID: 19796244    Free PMC article.
Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.
Penghui Zhou, Xianfeng Fang, +6 authors, Pan Zheng.
Proc Natl Acad Sci U S A, 2009 Oct 07; 106(40). PMID: 19805094    Free PMC article.
Immune responses to malignancies.
Theresa L Whiteside.
J Allergy Clin Immunol, 2010 Jan 12; 125(2 Suppl 2). PMID: 20061007    Free PMC article.
Review.
Pilot study of sentinel-node-based adoptive immunotherapy in advanced colorectal cancer.
Mona Karlsson, Per Marits, +4 authors, Ola Winqvist.
Ann Surg Oncol, 2010 Feb 02; 17(7). PMID: 20119674    Free PMC article.
T-cell exhaustion: characteristics, causes and conversion.
John S Yi, Maureen A Cox, Allan J Zajac.
Immunology, 2010 Mar 06; 129(4). PMID: 20201977    Free PMC article.
Highly Cited. Review.
Enhanced CD8 T cell cross-presentation by macrophages with targeted disruption of STAT3.
Jason Brayer, Fengdong Cheng, +4 authors, Eduardo M Sotomayor.
Immunol Lett, 2010 Mar 30; 131(2). PMID: 20346983    Free PMC article.
Shaping successful and unsuccessful CD8 T cell responses following infection.
Maureen A Cox, Allan J Zajac.
J Biomed Biotechnol, 2010 Apr 10; 2010. PMID: 20379363    Free PMC article.
Review.
Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression.
Theresa L Whiteside.
Expert Opin Biol Ther, 2010 Apr 27; 10(7). PMID: 20415597    Free PMC article.
Review.
Dendritic cell subsets as vectors and targets for improved cancer therapy.
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Curr Top Microbiol Immunol, 2010 May 22; 344. PMID: 20490776    Free PMC article.
Review.
Dendritic cells: are they clinically relevant?
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693842    Free PMC article.
Review.
IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells.
Mary Zimmerman, Dafeng Yang, +8 authors, Kebin Liu.
PLoS One, 2010 Dec 03; 5(11). PMID: 21124930    Free PMC article.
Mechanisms of T-cell protection from death by IRX-2: a new immunotherapeutic.
Malgorzata Czystowska, Miroslaw J Szczepanski, +4 authors, Theresa L Whiteside.
Cancer Immunol Immunother, 2010 Dec 25; 60(4). PMID: 21181158    Free PMC article.
Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases.
John Puskas, Denise Skrombolas, +3 authors, John Frelinger.
Immunology, 2011 Mar 24; 133(2). PMID: 21426339    Free PMC article.
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
Arne N Akbar, Sian M Henson.
Nat Rev Immunol, 2011 Mar 26; 11(4). PMID: 21436838
Highly Cited.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies.
Amy E Gilbert, Panagiotis Karagiannis, +16 authors, Sophia N Karagiannis.
PLoS One, 2011 May 12; 6(4). PMID: 21559411    Free PMC article.
A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells.
Chao Ma, Rong Fan, +9 authors, James R Heath.
Nat Med, 2011 May 24; 17(6). PMID: 21602800    Free PMC article.
Highly Cited.
T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine.
Moses K Donkor, Abira Sarkar, +5 authors, Ming O Li.
Immunity, 2011 Jul 16; 35(1). PMID: 21757379    Free PMC article.
Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis.
Mark M Davis, John D Altman, Evan W Newell.
Nat Rev Immunol, 2011 Jul 16; 11(8). PMID: 21760610    Free PMC article.
Review.
Why Do CD8+ T Cells become Indifferent to Tumors: A Dynamic Modeling Approach.
Colin Campbell, Ranran Zhang, +5 authors, Juilee Thakar.
Front Physiol, 2011 Aug 03; 2. PMID: 21808621    Free PMC article.
A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens.
Michael D Valentino, C Siddiq Abdul-Alim, +7 authors, John G Frelinger.
J Immunol Methods, 2011 Aug 30; 373(1-2). PMID: 21872603    Free PMC article.
Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses.
Charles B Kemmler, Eric T Clambey, Ross M Kedl, Jill E Slansky.
J Immunol, 2011 Sep 24; 187(9). PMID: 21940675    Free PMC article.
Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination.
Wolfgang Kratky, Caetano Reis e Sousa, Annette Oxenius, Roman Spörri.
Proc Natl Acad Sci U S A, 2011 Oct 12; 108(42). PMID: 21987815    Free PMC article.
Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).
Carsten Schaefer, Lisa H Butterfield, +5 authors, Theresa L Whiteside.
Int J Cancer, 2011 Oct 25; 131(4). PMID: 22021080    Free PMC article.
Deconvolving heterogeneity in the CD8+ T-cell response to HIV.
W Nicholas Haining, R Anthony Barnitz.
Curr Opin HIV AIDS, 2011 Dec 14; 7(1). PMID: 22156844    Free PMC article.
Review.
Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer.
Neil Senzer, Minal Barve, +23 authors, John Nemunaitis.
Mol Ther, 2011 Dec 22; 20(3). PMID: 22186789    Free PMC article.
Melanoma: new insights and new therapies.
Vasiliki A Nikolaou, Alexander J Stratigos, Keith T Flaherty, Hensin Tsao.
J Invest Dermatol, 2012 Jan 06; 132(3 Pt 2). PMID: 22217739    Free PMC article.
Review.
T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer.
Abira Sarkar, Moses K Donkor, Ming O Li.
Oncotarget, 2012 Jan 18; 2(12). PMID: 22248703    Free PMC article.
Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses.
Arya Biragyn, Dan L Longo.
Semin Cancer Biol, 2012 Jan 20; 22(1). PMID: 22257681    Free PMC article.
Review.
Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo.
Chengwen Liu, Carol M Lewis, +8 authors, Patrick Hwu.
J Immunother, 2012 Mar 17; 35(3). PMID: 22421945    Free PMC article.
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells.
John J Engelhardt, Bijan Boldajipour, +5 authors, Matthew F Krummel.
Cancer Cell, 2012 Mar 24; 21(3). PMID: 22439936    Free PMC article.
Highly Cited.
Positive and negative regulation of cellular immune responses in physiologic conditions and diseases.
S Viganò, M Perreau, G Pantaleo, A Harari.
Clin Dev Immunol, 2012 May 02; 2012. PMID: 22548114    Free PMC article.
Review.
Reflections upon human cancer immune responsiveness to T cell-based therapy.
Ena Wang, Sara Tomei, Francesco M Marincola.
Cancer Immunol Immunother, 2012 May 12; 61(6). PMID: 22576055    Free PMC article.
Review.
Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma.
Elisa Menicali, Sonia Moretti, +3 authors, Efisio Puxeddu.
Front Endocrinol (Lausanne), 2012 Jun 05; 3. PMID: 22661970    Free PMC article.
Tgf-β1 produced by activated CD4(+) T Cells Antagonizes T Cell Surveillance of Tumor Development.
Moses K Donkor, Abira Sarkar, Ming O Li.
Oncoimmunology, 2012 Jun 22; 1(2). PMID: 22720237    Free PMC article.
NFAT1 supports tumor-induced anergy of CD4(+) T cells.
Brian T Abe, Daniel S Shin, Enric Mocholi, Fernando Macian.
Cancer Res, 2012 Aug 07; 72(18). PMID: 22865456    Free PMC article.
CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.
Yoav Peretz, Zhong He, +14 authors, Rafick-Pierre Sékaly.
PLoS Pathog, 2012 Aug 24; 8(8). PMID: 22916009    Free PMC article.
Improving T cell responses to modified peptides in tumor vaccines.
Jonathan D Buhrman, Jill E Slansky.
Immunol Res, 2012 Sep 01; 55(1-3). PMID: 22936035    Free PMC article.
Review.
Augmenting antitumor T-cell responses to mimotope vaccination by boosting with native tumor antigens.
Jonathan D Buhrman, Kimberly R Jordan, +3 authors, Jill E Slansky.
Cancer Res, 2012 Nov 20; 73(1). PMID: 23161490    Free PMC article.
Inefficient boosting of antitumor CD8(+) T cells by dendritic-cell vaccines is rescued by restricting T-cell cytotoxic functions.
Joel Zhi-Iong Ma, Jianping Yang, +5 authors, Franca Ronchese.
Oncoimmunology, 2012 Dec 25; 1(9). PMID: 23264897    Free PMC article.
Enhanced function of cytotoxic T lymphocytes induced by dendritic cells modified with truncated PSMA and 4-1BBL.
Kuang Youlin, Zhang Li, +3 authors, Weng Xiaodong.
Hum Vaccin Immunother, 2013 Jan 09; 9(4). PMID: 23295983    Free PMC article.
KIR gene variability in cutaneous malignant melanoma: influence of KIR2D/HLA-C pairings on disease susceptibility and prognosis.
José A Campillo, Isabel Legaz, +10 authors, Jorge A Martínez-Escribano.
Immunogenetics, 2013 Feb 02; 65(5). PMID: 23370861
Targeted therapy and immunotherapy in advanced melanoma: an evolving paradigm.
Muhammad Khattak, Rosalie Fisher, Samra Turajlic, James Larkin.
Ther Adv Med Oncol, 2013 Mar 02; 5(2). PMID: 23450149    Free PMC article.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
Adam J Adler, Anthony T Vella.
Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891    Free PMC article.
PD-1 coinhibitory signals: the link between pathogenesis and protection.
Deanna A Kulpa, Mariam Lawani, +3 authors, Rafick-Pierre Sékaly.
Semin Immunol, 2013 Apr 04; 25(3). PMID: 23548749    Free PMC article.
Review.
Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma.
Sunitha Kakarla, Kevin K H Chow, +8 authors, Stephen Gottschalk.
Mol Ther, 2013 Jun 05; 21(8). PMID: 23732988    Free PMC article.
Highly Cited.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski.
Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400    Free PMC article.
Highly Cited.
Sindbis viral vectors transiently deliver tumor-associated antigens to lymph nodes and elicit diversified antitumor CD8+ T-cell immunity.
Tomer Granot, Yoshihide Yamanashi, Daniel Meruelo.
Mol Ther, 2013 Sep 13; 22(1). PMID: 24025748    Free PMC article.
Allogeneic tumor cell vaccines: the promise and limitations in clinical trials.
Sanjay Srivatsan, Jaina M Patel, +4 authors, Periasamy Selvaraj.
Hum Vaccin Immunother, 2013 Sep 26; 10(1). PMID: 24064957    Free PMC article.
Review.
Stem cells and targeted approaches to melanoma cure.
George F Murphy, Brian J Wilson, +2 authors, Markus H Frank.
Mol Aspects Med, 2013 Oct 23; 39. PMID: 24145241    Free PMC article.
Review.
Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.
Pauline Weder, Ton N M Schumacher, Hergen Spits, Rosalie M Luiten.
Results Immunol, 2012 Jan 01; 2. PMID: 24371571    Free PMC article.
Monitoring the immune competence of cancer patients to predict outcome.
Serena Chang, Holbrook Kohrt, Holden T Maecker.
Cancer Immunol Immunother, 2014 Feb 04; 63(7). PMID: 24487923    Free PMC article.
Review.
High-dimensional single-cell cancer biology.
Jonathan M Irish, Deon B Doxie.
Curr Top Microbiol Immunol, 2014 Mar 29; 377. PMID: 24671264    Free PMC article.
Review.
Melanoma NOS1 expression promotes dysfunctional IFN signaling.
Qiuzhen Liu, Sara Tomei, +19 authors, Francesco M Marincola.
J Clin Invest, 2014 Apr 03; 124(5). PMID: 24691438    Free PMC article.
ELISPOT Assay for Monitoring Cytotoxic T Lymphocytes (CTL) Activity in Cancer Vaccine Clinical Trials.
Anatoli M Malyguine, Susan Strobl, +2 authors, Thomas J Sayers.
Cells, 2012 Jan 01; 1(2). PMID: 24710418    Free PMC article.
Shaping the repertoire of tumor-infiltrating effector and regulatory T cells.
Peter A Savage, Daniel S Leventhal, Sven Malchow.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712470    Free PMC article.
Review.
Control of the immune response by pro-angiogenic factors.
Thibault Voron, Elie Marcheteau, +4 authors, Magali Terme.
Front Oncol, 2014 Apr 26; 4. PMID: 24765614    Free PMC article.
Highly Cited. Review.
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity.
Liang-Chuan S Wang, Albert Lo, +11 authors, Steven M Albelda.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778279    Free PMC article.
Highly Cited.
Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation.
Jonathan M Eby, Hee-Kap Kang, +8 authors, I Caroline Le Poole.
Pigment Cell Melanoma Res, 2014 Jun 18; 27(6). PMID: 24935676    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
Treatment of unresectable stage IV metastatic melanoma with aviscumine after anti-neoplastic treatment failure: a phase II, multi-centre study.
Uwe Trefzer, Ralf Gutzmer, +6 authors, Peter Mohr.
J Immunother Cancer, 2014 Oct 18; 2. PMID: 25324973    Free PMC article.
Immune response in thyroid cancer: widening the boundaries.
Laura Sterian Ward.
Scientifica (Cairo), 2014 Oct 21; 2014. PMID: 25328756    Free PMC article.
Review.
To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy.
Jessica E Thaxton, Zihai Li.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483644    Free PMC article.
Review.
Current advances in T-cell-based cancer immunotherapy.
Mingjun Wang, Bingnan Yin, Helen Y Wang, Rong-Fu Wang.
Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524383    Free PMC article.
Review.
Immune profiling and cancer post transplantation.
Christopher Martin Hope, Patrick Toby H Coates, Robert Peter Carroll.
World J Nephrol, 2015 Feb 11; 4(1). PMID: 25664246    Free PMC article.
Review.
Overcoming T cell exhaustion in infection and cancer.
Kristen E Pauken, E John Wherry.
Trends Immunol, 2015 Mar 24; 36(4). PMID: 25797516    Free PMC article.
Highly Cited. Review.
MHC class I chain-related gene a diversity in patients with cutaneous malignant melanoma from southeastern Spain.
José Antonio Campillo, Ruth López-Hernández, +13 authors, Manuel Muro.
Dis Markers, 2015 Apr 04; 2015. PMID: 25838620    Free PMC article.
An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen.
Matthew P Rausch, Karen Taraszka Hastings.
PLoS One, 2015 Apr 16; 10(4). PMID: 25875653    Free PMC article.
Melanoma-derived factors alter the maturation and activation of differentiated tissue-resident dendritic cells.
Kristian M Hargadon, Johnathan D Bishop, +3 authors, Osric A Forrest.
Immunol Cell Biol, 2015 May 27; 94(1). PMID: 26010746
Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer.
Jie Chen, Qiwen Deng, +5 authors, Shukui Wang.
FEBS Open Bio, 2015 Jul 03; 5. PMID: 26137435    Free PMC article.
Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer.
Edmund K Moon, Raghuveer Ranganathan, +7 authors, Steven M Albelda.
Clin Cancer Res, 2015 Sep 02; 22(2). PMID: 26324743    Free PMC article.
Targeting cryptic epitope with modified antigen coupled to the surface of liposomes induces strong antitumor CD8 T-cell immune responses in vivo.
Yutaka Horiuchi, Akira Takagi, Tetsuya Uchida, Toshitaka Akatsuka.
Oncol Rep, 2015 Sep 24; 34(6). PMID: 26398429    Free PMC article.
Screening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array.
Yu-Yen Huang, Peng Chen, +7 authors, John X J Zhang.
Sci Rep, 2015 Nov 06; 5. PMID: 26538094    Free PMC article.
A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality.
Wei Zhu, Claire Germain, +12 authors, Brandon W Higgs.
Oncoimmunology, 2015 Nov 21; 4(12). PMID: 26587322    Free PMC article.
Tailoring the Treatment of Melanoma: Implications for Personalized Medicine.
Linna Duan, Eric M Mukherjee, Deepak Narayan.
Yale J Biol Med, 2015 Nov 26; 88(4). PMID: 26604863    Free PMC article.
Review.
Obligate anaerobic Salmonella typhimurium strain YB1 treatment on xenograft tumor in immunocompetent mouse model.
Bin Yu, Lei Shi, +4 authors, Jun-LE Qu.
Oncol Lett, 2015 Dec 02; 10(2). PMID: 26622627    Free PMC article.
Single-cell analysis tools for drug discovery and development.
James R Heath, Antoni Ribas, Paul S Mischel.
Nat Rev Drug Discov, 2015 Dec 17; 15(3). PMID: 26669673    Free PMC article.
Highly Cited. Review.
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape.
Sanmay Bandyopadhyay, Thomas J Quinn, +5 authors, Chandan Guha.
J Immunol, 2016 Jan 13; 196(4). PMID: 26755821    Free PMC article.
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients.
Amos Kirilovsky, Florence Marliot, +3 authors, Franck Pagès.
Int Immunol, 2016 Apr 29; 28(8). PMID: 27121213    Free PMC article.
Highly Cited. Review.
Anticancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response.
Jessie Thalmensi, Elodie Pliquet, +12 authors, Pierre Langlade-Demoyen.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141336    Free PMC article.
Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy.
Boris Simovic, Scott R Walsh, Yonghong Wan.
Oncolytic Virother, 2015 Jan 01; 4. PMID: 27512679    Free PMC article.
Review.
Regulatory circuits of T cell function in cancer.
Daniel E Speiser, Ping-Chih Ho, Grégory Verdeil.
Nat Rev Immunol, 2016 Aug 17; 16(10). PMID: 27526640
Highly Cited. Review.
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.
Qian Chen, Ligeng Xu, +3 authors, Zhuang Liu.
Nat Commun, 2016 Oct 22; 7. PMID: 27767031    Free PMC article.
Highly Cited.
Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.
Hazem E Ghoneim, Anthony E Zamora, Paul G Thomas, Ben A Youngblood.
Trends Mol Med, 2016 Nov 09; 22(12). PMID: 27825667    Free PMC article.
Review.
Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine.
Bijan Boldajipour, Amanda Nelson, Matthew F Krummel.
JCI Insight, 2016 Dec 13; 1(20). PMID: 27942588    Free PMC article.
The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.
Shona A Hendry, Rae H Farnsworth, +3 authors, Stephen B Fox.
Front Immunol, 2017 Jan 10; 7. PMID: 28066431    Free PMC article.
Highly Cited. Review.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger.
Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373    Free PMC article.
Highly Cited. Review.
The Principles of Engineering Immune Cells to Treat Cancer.
Wendell A Lim, Carl H June.
Cell, 2017 Feb 12; 168(4). PMID: 28187291    Free PMC article.
Highly Cited. Review.
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Curr Protoc Mol Biol, 2017 Apr 04; 118. PMID: 28369679    Free PMC article.
Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack.
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Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System.
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Front Immunol, 2017 Jun 24; 8. PMID: 28638382    Free PMC article.
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The Antitumor Effects of Vaccine-Activated CD8+ T Cells Associate with Weak TCR Signaling and Induction of Stem-Like Memory T Cells.
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Cancer Immunol Res, 2017 Aug 31; 5(10). PMID: 28851693    Free PMC article.
Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection.
Jeffrey E Teigler, Gennadiy Zelinskyy, +11 authors, Hendrik Streeck.
J Virol, 2017 Sep 15; 91(23). PMID: 28904197    Free PMC article.
Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma.
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T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.
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Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.
Marjolein W J Wentink, Yvonne M Mueller, +5 authors, Peter D Katsikis.
Front Immunol, 2018 Mar 23; 9. PMID: 29563914    Free PMC article.
Current Strategies to Enhance Anti-Tumour Immunity.
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T-cell Dysfunction in Glioblastoma: Applying a New Framework.
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IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy.
Jianmin Zhu, Jin-Qing Liu, +11 authors, Xue-Feng Bai.
JCI Insight, 2018 Apr 06; 3(7). PMID: 29618655    Free PMC article.
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Tingting Wang, Dangge Wang, +6 authors, Yaping Li.
Nat Commun, 2018 Apr 20; 9(1). PMID: 29670088    Free PMC article.
Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) Tax-specific T-cell exhaustion in HTLV-1-infected individuals.
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Cancer Sci, 2018 May 31; 109(8). PMID: 29845702    Free PMC article.
The expansion of targetable biomarkers for CAR T cell therapy.
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The impact of inflationary cytomegalovirus-specific memory T cells on anti-tumour immune responses in patients with cancer.
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Immunology, 2018 Aug 12; 155(3). PMID: 30098205    Free PMC article.
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Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression.
Colt A Egelston, Christian Avalos, +9 authors, Peter P Lee.
Nat Commun, 2018 Oct 18; 9(1). PMID: 30327458    Free PMC article.
T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide-MHC complexes.
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Nat Biotechnol, 2018 Nov 20;. PMID: 30451992
The prognostic role of circulating CD8+ T cell proliferation in patients with untreated extensive stage small cell lung cancer.
Ning An, Haoyi Wang, +4 authors, Jinming Yu.
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Differential Expression of Immune Checkpoint Molecules on CD8+ T Cells Specific for Immunodominant and Subdominant Herpes Simplex Virus 1 Epitopes.
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J Virol, 2019 Oct 28; 94(2). PMID: 31645447    Free PMC article.
DNA-Barcoded pMHC Tetramers for Detection of Single Antigen-Specific T Cells by Digital PCR.
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Anal Chem, 2019 Jan 19; 91(4). PMID: 30656939    Free PMC article.
Pegylated recombinant human granulocyte colony-stimulating factor regulates the immune status of patients with small cell lung cancer.
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A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4+ T and Natural Killer Cells.
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Semin Immunopathol, 2019 Apr 17; 41(3). PMID: 30989321
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Curr Opin Endocrinol Diabetes Obes, 2019 Jun 04; 26(4). PMID: 31157632    Free PMC article.
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Melanoma and Vitiligo: In Good Company.
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Biophysicochemical motifs in T cell receptor sequences as a potential biomarker for high-grade serous ovarian carcinoma.
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PLoS One, 2020 Mar 07; 15(3). PMID: 32134923    Free PMC article.
Re-defining T-Cell Exhaustion: Subset, Function, and Regulation.
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The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.
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Preferential Homing of Tumor-specific and Functional CD8+ Stem Cell-like Memory T Cells to the Bone Marrow.
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Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?
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Front Immunol, 2019 Jun 14; 10. PMID: 31191545    Free PMC article.
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Identification of novel human leukocyte antigen-A*11:01-restricted cytotoxic T-lymphocyte epitopes derived from osteosarcoma antigen papillomavirus binding factor.
Dongliang Li, Shingo Toji, +2 authors, Tomohide Tsukahara.
Cancer Sci, 2019 Feb 16; 110(4). PMID: 30767336    Free PMC article.
Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma.
Akiko Arakawa, Sigrid Vollmer, +5 authors, Jörg C Prinz.
Front Immunol, 2019 Jul 06; 10. PMID: 31275310    Free PMC article.
Ushering in Integrated T Cell Repertoire Profiling in Cancer.
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Perspective: Designing T-Cell Engagers With Better Therapeutic Windows.
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Front Oncol, 2020 May 01; 10. PMID: 32351885    Free PMC article.
Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3-CD8+ T cells.
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JCI Insight, 2020 Apr 10; 5(7). PMID: 32271164    Free PMC article.
T-cell exhaustion correlates with improved outcomes in kidney transplant recipients.
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Precision Medicine for NSCLC in the Era of Immunotherapy: New Biomarkers to Select the Most Suitable Treatment or the Most Suitable Patient.
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Old dogs, new trick: classic cancer therapies activate cGAS.
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The Ways of Isolating Neoantigen-Specific T Cells.
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Multitarget Direct-Acting Antiviral Therapy Is Associated With Superior Immunologic Recovery in Patients Coinfected With Human Immunodeficiency Virus and Hepatitis C Virus.
Shikha Shrivastava, Manasa Bhatta, +8 authors, Eleanor Wilson.
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Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases.
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NKG2D Polymorphism in Melanoma Patients from Southeastern Spain.
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Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation, Dysfunction and Exhaustion.
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Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer.
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Combining therapeutic vaccines with chemo- and immunotherapies in the treatment of cancer.
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Functional T Cell Reactivity to Melanocyte Antigens Is Lost during the Progression of Malignant Melanoma, but Is Restored by Immunization.
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Daria Beshnova, Jianfeng Ye, +6 authors, Bo Li.
Sci Transl Med, 2020 Aug 21; 12(557). PMID: 32817363    Free PMC article.
Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy.
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Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis.
Amy I Yu, Lili Zhao, +13 authors, Grace Y Chen.
Cell Rep, 2020 Apr 09; 31(1). PMID: 32268087    Free PMC article.
Metabolic barriers to cancer immunotherapy.
Kristin DePeaux, Greg M Delgoffe.
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Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment.
Linbang Wang, Tao He, +4 authors, Zhengxue Quan.
Exp Hematol Oncol, 2021 May 12; 10(1). PMID: 33971970    Free PMC article.
Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities.
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Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells.
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Cell Rep, 2021 May 13; 35(6). PMID: 33979613    Free PMC article.
Fibroblasts Influence the Efficacy, Resistance, and Future Use of Vaccines and Immunotherapy in Cancer Treatment.
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Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells.
Nicholas J Maurice, Jacqueline Berner, +2 authors, Martin Prlic.
JCI Insight, 2021 May 26; 6(13). PMID: 34032638    Free PMC article.
HLA-DRB1∗16:01 and HLA-DQB1∗05:02 Alleles Influence the Susceptibility and Progression of Cutaneous Malignant Melanoma.
Xu Wang, Francisco Almazan, +4 authors, Miguel Angel López-Nevot.
J Oncol, 2021 Oct 12; 2021. PMID: 34630564    Free PMC article.
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigens.
Sung-Woo Lee, He Yun Choi, +6 authors, Jae-Ho Cho.
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Anti-PD-1 Checkpoint Therapy Can Promote the Function and Survival of Regulatory T Cells.
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Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.
Youmna Kfoury, Ninib Baryawno, +16 authors, as part of the Boston Bone Metastases Consortium.
Cancer Cell, 2021 Nov 02; 39(11). PMID: 34719426    Free PMC article.
Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors.
Samuel Rivero-Hinojosa, Melanie Grant, +4 authors, Brian R Rood.
Nat Commun, 2021 Nov 20; 12(1). PMID: 34795224    Free PMC article.
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients.
Chuan Li, Yee Peng Phoon, +19 authors, Brian R Gastman.
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Single-Cell Transcriptome Analysis Reveals RGS1 as a New Marker and Promoting Factor for T-Cell Exhaustion in Multiple Cancers.
Yunmeng Bai, Meiling Hu, +2 authors, Hongli Du.
Front Immunol, 2021 Dec 28; 12. PMID: 34956194    Free PMC article.
Tumor vaccines and beyond.
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An In Vivo Screen to Identify Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity.
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Cancer Immunol Res, 2022 Jan 08; 10(3). PMID: 34992135    Free PMC article.