Journal Article
. 1999 Jul; 59(13):3128-33.

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody

S Onizuka 1 I Tawara  J Shimizu  S Sakaguchi  T Fujita  E Nakayama  
  • PMID: 10397255
  •     336 citations


Immune regulation has been shown to be involved in the progressive growth of some murine tumors. In this study, we demonstrated that a single in vivo administration of an amount less than 0.125 mg of anti-CD25 interleukin 2 receptor alpha monoclonal antibody (mAb; PC61) caused the regression of tumors that grew progressively in syngeneic mice. The tumors used were five leukemias, a myeloma, and two sarcomas derived from four different inbred mouse strains. Anti-CD25 mAb (PC61) showed an effect in six of the eight tumors. Administration of anti-CD25 mAb (PC61) caused a reduction in the number of CD4+ CD25+ cells in the peripheral lymphoid tissues. The findings suggested that CD4+ CD25+ immunoregulatory cells were involved in the growth of those tumors. Kinetic analysis showed that the administration of anti-CD25 mAb (PC61) later than day 2 after tumor inoculation caused no tumor regression, irrespective of depletion of CD4+ CD25+ immunoregulatory cells. Two leukemias, on which the PC61-treatment had no effect, seemed to be incapable of eliciting effective rejection responses in the recipient mice because of low or no antigenicity.

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Juan R Cubillos-Ruiz, Melanie Rutkowski, Jose R Conejo-Garcia.
Cell Cycle, 2009 Dec 22; 9(2). PMID: 20023378    Free PMC article.
High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma.
Jochen Greiner, Anita Schmitt, +9 authors, Michael Schmitt.
Haematologica, 2010 Jan 19; 95(7). PMID: 20081055    Free PMC article.
The role of regulatory T cells in cancer.
Tai-You Ha.
Immune Netw, 2010 Feb 17; 9(6). PMID: 20157609    Free PMC article.
Vaccines against human carcinomas: strategies to improve antitumor immune responses.
Claudia Palena, Jeffrey Schlom.
J Biomed Biotechnol, 2010 Mar 20; 2010. PMID: 20300434    Free PMC article.
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts.
Sankar Bhattacharyya, Dewan Md Sakib Hossain, +8 authors, Gaurisankar Sa.
Cell Mol Immunol, 2010 Mar 23; 7(4). PMID: 20305684    Free PMC article.
Effective depletion of regulatory T cells allows the recruitment of mesothelin-specific CD8 T cells to the antitumor immune response against a mesothelin-expressing mouse pancreatic adenocarcinoma.
Ihid C Leao, Priya Ganesan, Todd D Armstrong, Elizabeth M Jaffee.
Clin Transl Sci, 2008 Oct 24; 1(3). PMID: 20357913    Free PMC article.
Proliferation of CD4CD25Foxp3 regulatory T lymphocytes in ex vivo expanded ascitic fluid from primary and recurrent ovarian carcinoma.
Shin Wha Lee, Yong-Man Kim, +4 authors, Young-Tak Kim.
J Gynecol Oncol, 2010 Apr 10; 21(1). PMID: 20379446    Free PMC article.
Monoclonal antibodies: versatile platforms for cancer immunotherapy.
Louis M Weiner, Rishi Surana, Shangzi Wang.
Nat Rev Immunol, 2010 Apr 24; 10(5). PMID: 20414205    Free PMC article.
Highly Cited. Review.
Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.
Yannick D Muller, Gang Mai, +12 authors, Leo H Bühler.
PLoS One, 2010 May 04; 5(4). PMID: 20436684    Free PMC article.
Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells.
A-S Bergot, A Durgeau, +3 authors, D Klatzmann.
Cancer Gene Ther, 2010 May 15; 17(9). PMID: 20467452    Free PMC article.
Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine.
M Eric Kohler, William H D Hallett, +3 authors, Rimas J Orentas.
Cell Immunol, 2010 Aug 10; 265(1). PMID: 20692654    Free PMC article.
Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta.
Kwesi Frimpong-Boateng, Nico van Rooijen, Ralf Geiben-Lynn.
PLoS One, 2010 Sep 03; 5(8). PMID: 20808850    Free PMC article.
Attenuated T cell responses to a high-potency ligand in vivo.
Emily Corse, Rachel A Gottschalk, Michelle Krogsgaard, James P Allison.
PLoS Biol, 2010 Sep 22; 8(9). PMID: 20856903    Free PMC article.
Vaccines and immunotherapeutics for the treatment of malignant disease.
Joel F Aldrich, Devin B Lowe, +3 authors, Ronald C Kennedy.
Clin Dev Immunol, 2010 Oct 12; 2010. PMID: 20936120    Free PMC article.
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
Sandra Hubert, Björn Rissiek, +7 authors, Sahil Adriouch.
J Exp Med, 2010 Oct 27; 207(12). PMID: 20975043    Free PMC article.
A strategy of tumor treatment in mice with doxorubicin-cyclophosphamide combination based on dendritic cell activation by human double-stranded DNA preparation.
Ekaterina A Alyamkina, Valeriy P Nikolin, +11 authors, Mikhail A Shurdov.
Genet Vaccines Ther, 2010 Nov 03; 8. PMID: 21040569    Free PMC article.
Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.
Adam W Mailloux, M Rita I Young.
Crit Rev Immunol, 2010 Nov 19; 30(5). PMID: 21083525    Free PMC article.
A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4(+)FOXP3(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix.
Walayat Shah, Xiaofei Yan, +3 authors, Yili Wang.
Cell Mol Immunol, 2011 Jan 05; 8(1). PMID: 21200385    Free PMC article.
Immunotherapeutic modulation of the suppressive liver and tumor microenvironments.
Tim Chan, Robert H Wiltrout, Jonathan M Weiss.
Int Immunopharmacol, 2011 Jan 19; 11(7). PMID: 21241810    Free PMC article.
Immunotherapy for renal cell carcinoma.
Momoe Itsumi, Katsunori Tatsugami.
Clin Dev Immunol, 2011 Jan 22; 2010. PMID: 21253521    Free PMC article.
Nondominant CD8 T cells are active players in the vaccine-induced antitumor immune response.
Jennifer N Uram, Chelsea M Black, +3 authors, Elizabeth M Jaffee.
J Immunol, 2011 Feb 25; 186(7). PMID: 21346233    Free PMC article.
Microbiota regulates immune defense against respiratory tract influenza A virus infection.
Takeshi Ichinohe, Iris K Pang, +4 authors, Akiko Iwasaki.
Proc Natl Acad Sci U S A, 2011 Mar 16; 108(13). PMID: 21402903    Free PMC article.
Highly Cited.
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.
Alice McNally, Geoffrey R Hill, +2 authors, Raymond J Steptoe.
Proc Natl Acad Sci U S A, 2011 Apr 20; 108(18). PMID: 21502514    Free PMC article.
Depletion of CD25⁺ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma.
Weiqing Jing, Xiaocai Yan, +2 authors, Bryon D Johnson.
Blood, 2011 Apr 28; 117(25). PMID: 21521781    Free PMC article.
TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo.
Sayuri Yamazaki, Kohei Okada, +3 authors, Tsukasa Seya.
PLoS One, 2011 May 03; 6(4). PMID: 21533081    Free PMC article.
How tumors might withstand γδ T-cell attack.
Aude-Hélène Capietto, Ludovic Martinet, Jean-Jacques Fournié.
Cell Mol Life Sci, 2011 May 07; 68(14). PMID: 21547501
Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice.
Jinlin Liu, Ning Zhang, +6 authors, Honglin Wang.
PLoS One, 2011 May 12; 6(4). PMID: 21559338    Free PMC article.
Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer.
P Goedegebuure, J B Mitchem, +6 authors, D C Linehan.
Curr Cancer Drug Targets, 2011 May 24; 11(6). PMID: 21599634    Free PMC article.
Immunomodulatory effects of cyclophosphamide and implementations for vaccine design.
Antonella Sistigu, Sophie Viaud, +3 authors, Laurence Zitvogel.
Semin Immunopathol, 2011 May 26; 33(4). PMID: 21611872
Highly Cited. Review.
Dual roles of immune cells and their factors in cancer development and progression.
Brian F Zamarron, WanJun Chen.
Int J Biol Sci, 2011 Jun 08; 7(5). PMID: 21647333    Free PMC article.
Highly Cited. Review.
Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses.
Shannon E Smith, Dominique B Hoelzinger, +2 authors, Joseph Lustgarten.
Cancer Immunol Immunother, 2011 Jul 27; 60(12). PMID: 21789593    Free PMC article.
Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin.
Mario Orozco-Morales, Francisco-Javier Sánchez-García, +7 authors, Julio Sotelo.
J Cancer Res Clin Oncol, 2011 Sep 29; 138(1). PMID: 21947268
Immune recovery after cyclophosphamide treatment in multiple myeloma: implication for maintenance immunotherapy.
Amir Sharabi, Nechama Haran-Ghera.
Bone Marrow Res, 2011 Nov 03; 2011. PMID: 22046558    Free PMC article.
Granzyme B regulates antiviral CD8+ T cell responses.
Suzan M Salti, Erin M Hammelev, +5 authors, James W Verbsky.
J Immunol, 2011 Nov 16; 187(12). PMID: 22084442    Free PMC article.
Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells.
Li Wang, Jinpiao Lin, +4 authors, Ningli Li.
PLoS One, 2011 Nov 17; 6(11). PMID: 22087281    Free PMC article.
Suppression of tumour-specific CD4⁺ T cells by regulatory T cells is associated with progression of human colorectal cancer.
Gareth Betts, Emma Jones, +9 authors, Andrew Godkin.
Gut, 2011 Dec 31; 61(8). PMID: 22207629    Free PMC article.
Regulatory immunotherapy in bone marrow transplantation.
Vanessa Morales-Tirado, Wioleta Luszczek, Marié van der Merwe, Asha Pillai.
ScientificWorldJournal, 2012 Jan 21; 11. PMID: 22262950    Free PMC article.
Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch.
Chuanwu Wang, Jee H Lee, Chang H Kim.
PLoS One, 2012 Feb 01; 7(1). PMID: 22292042    Free PMC article.
Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models.
Li Shen, Michael Ciesielski, +6 authors, Roberto Pili.
PLoS One, 2012 Feb 04; 7(1). PMID: 22303460    Free PMC article.
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
John H Sampson, Robert J Schmittling, +13 authors, Duane A Mitchell.
PLoS One, 2012 Mar 03; 7(2). PMID: 22383993    Free PMC article.
Myeloid suppressor cells and immune modulation in lung cancer.
Minu K Srivastava, Åsa Andersson, +4 authors, Sherven Sharma.
Immunotherapy, 2012 Mar 10; 4(3). PMID: 22401635    Free PMC article.
The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells.
Bong Ihn Koh, Yibin Kang.
EMBO Rep, 2012 Apr 05; 13(5). PMID: 22473297    Free PMC article.
Regulatory T cells in human ovarian cancer.
Dong-Jun Peng, Rebecca Liu, Weiping Zou.
J Oncol, 2012 Apr 07; 2012. PMID: 22481922    Free PMC article.
Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immunosuppressive cells.
Yushe Dang, Wolfgang M Wagner, +4 authors, Mary L Disis.
Clin Cancer Res, 2012 Apr 19; 18(11). PMID: 22510348    Free PMC article.
T-regulatory cells: key players in tumor immune escape and angiogenesis.
Andrea Facciabene, Gregory T Motz, George Coukos.
Cancer Res, 2012 May 03; 72(9). PMID: 22549946    Free PMC article.
Highly Cited. Review.
CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients.
Andrew J Rech, Rosemarie Mick, +13 authors, Robert H Vonderheide.
Sci Transl Med, 2012 May 18; 4(134). PMID: 22593175    Free PMC article.
Highly Cited.
Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions.
Ivetta Danylesko, Katia Beider, Avichai Shimoni, Arnon Nagler.
Clin Dev Immunol, 2012 Jun 01; 2012. PMID: 22649466    Free PMC article.
Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.
Shawn M Jensen, Christopher G Twitty, +6 authors, Bernard A Fox.
J Immunol, 2012 Jun 23; 189(2). PMID: 22723522    Free PMC article.
Partial regulatory T cell depletion prior to schistosomiasis vaccination does not enhance the protection.
Xuefeng Wang, Fan Liu, +8 authors, Chuan Su.
PLoS One, 2012 Jul 18; 7(7). PMID: 22802961    Free PMC article.
Immunosuppressive prednisolone enhances early cholangiocarcinoma in Syrian hamsters with liver fluke infection and administration of N-nitrosodimethylamine.
Amornrat Juasook, Thidarut Boonmars, +7 authors, Ratchadawan Aukkanimart.
Pathol Oncol Res, 2012 Aug 02; 19(1). PMID: 22851165
NFAT1 supports tumor-induced anergy of CD4(+) T cells.
Brian T Abe, Daniel S Shin, Enric Mocholi, Fernando Macian.
Cancer Res, 2012 Aug 07; 72(18). PMID: 22865456    Free PMC article.
Expansion of effector memory regulatory T cells represents a novel prognostic factor in lower risk myelodysplastic syndrome.
Adam W Mailloux, Chiharu Sugimori, +7 authors, Pearlie K Epling-Burnette.
J Immunol, 2012 Aug 10; 189(6). PMID: 22875800    Free PMC article.
Adoptive cellular therapy enhances the helper T cell response and reduces the number of regulatory T cells.
Takeshi Ishikawa, Satoshi Kokura, +12 authors, Toshikazu Yoshikawa.
Exp Ther Med, 2011 Jul 01; 2(4). PMID: 22977568    Free PMC article.
Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration.
John Karavitis, Laura M Hix, +3 authors, Ming Zhang.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029485    Free PMC article.
Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.
Wiebke Hansen, Marina Hutzler, +10 authors, Iris Helfrich.
J Exp Med, 2012 Oct 10; 209(11). PMID: 23045606    Free PMC article.
Highly Cited.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Comparative antitumor effect of preventive versus therapeutic vaccines employing B16 melanoma cells genetically modified to express GM-CSF and B7.2 in a murine model.
Antonio Miguel, María José Herrero, +4 authors, Salvador F Aliño.
Toxins (Basel), 2012 Dec 04; 4(11). PMID: 23202306    Free PMC article.
The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells.
Dennis Lindau, Paul Gielen, +2 authors, Gosse J Adema.
Immunology, 2012 Dec 12; 138(2). PMID: 23216602    Free PMC article.
Highly Cited. Review.
Radiation-induced effects and the immune system in cancer.
Punit Kaur, Alexzander Asea.
Front Oncol, 2012 Dec 20; 2. PMID: 23251903    Free PMC article.
Delicate balance among three types of T cells in concurrent regulation of tumor immunity.
Liat Izhak, Elena Ambrosino, +7 authors, Masaki Terabe.
Cancer Res, 2013 Jan 16; 73(5). PMID: 23319803    Free PMC article.
Effects of anticancer agents on cell viability, proliferative activity and cytokine production of peripheral blood mononuclear cells.
Hiromi Sakai, Satoshi Kokura, +12 authors, Toshikazu Yoshikawa.
J Clin Biochem Nutr, 2013 Jan 24; 52(1). PMID: 23341700    Free PMC article.
Immunoregulatory CD4(-)CD8(-) T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer.
Erin E Hillhouse, Jean-Sébastien Delisle, Sylvie Lesage.
Front Immunol, 2013 Jan 29; 4. PMID: 23355840    Free PMC article.
Influence of tumors on protective anti-tumor immunity and the effects of irradiation.
Gemma A Foulds, Jürgen Radons, +2 authors, Alan G Pockley.
Front Oncol, 2013 Feb 05; 3. PMID: 23378947    Free PMC article.
Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer.
Mia Kim, Tanja Grimmig, +9 authors, Martin Gasser.
PLoS One, 2013 Feb 06; 8(1). PMID: 23382847    Free PMC article.
Antigen choice determines vaccine-induced generation of immunogenic versus tolerogenic dendritic cells that are marked by differential expression of pancreatic enzymes.
Adam M Farkas, Douglas M Marvel, Olivera J Finn.
J Immunol, 2013 Feb 20; 190(7). PMID: 23420890    Free PMC article.
Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease.
Michael Weber, Corinna Lupp, +6 authors, Markus P Radsak.
PLoS One, 2013 Mar 14; 8(3). PMID: 23483980    Free PMC article.
Protumor activities of the immune response: insights in the mechanisms of immunological shift, oncotraining, and oncopromotion.
G K Chimal-Ramírez, N A Espinoza-Sánchez, E M Fuentes-Pananá.
J Oncol, 2013 Apr 12; 2013. PMID: 23577028    Free PMC article.
Tumor-related gene changes in immunosuppressive Syrian hamster cholangiocarcinoma.
Amornrat Juasook, Ratchadawan Aukkanimart, +4 authors, Pranee Sriraj.
Pathol Oncol Res, 2013 May 07; 19(4). PMID: 23645518
A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma.
Chen Chen, Jiajie Hou, +8 authors, Beicheng Sun.
Cell Mol Immunol, 2013 May 21; 10(4). PMID: 23686226    Free PMC article.
Targeting Tregs in Malignant Brain Cancer: Overcoming IDO.
Derek A Wainwright, Mahua Dey, Alan Chang, Maciej S Lesniak.
Front Immunol, 2013 May 31; 4. PMID: 23720663    Free PMC article.
Regulatory T cells in allogeneic stem cell transplantation.
Maria Michael, Avichai Shimoni, Arnon Nagler.
Clin Dev Immunol, 2013 Jun 06; 2013. PMID: 23737813    Free PMC article.
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer.
L Bracci, G Schiavoni, A Sistigu, F Belardelli.
Cell Death Differ, 2013 Jun 22; 21(1). PMID: 23787994    Free PMC article.
Highly Cited. Review.
Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.
Anusha-Preethi Ganesan, Magnus Johansson, +5 authors, Lisa M Coussens.
J Immunol, 2013 Jul 16; 191(4). PMID: 23851682    Free PMC article.
Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ foxp3+ ICOS- regulatory T cells.
Sheng Zhang, Lin-Kin Yong, +3 authors, Qizhi Yao.
PLoS One, 2013 Jul 23; 8(7). PMID: 23874581    Free PMC article.
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.
Jorg van Loosdregt, Veerle Fleskens, +15 authors, Paul J Coffer.
Immunity, 2013 Aug 27; 39(2). PMID: 23973222    Free PMC article.
Highly Cited.
Depletion of CD4+ CD25+ regulatory T cells promotes CCL21-mediated antitumor immunity.
Shuang Zhou, Long Chen, +10 authors, Chunmin Liang.
PLoS One, 2013 Sep 12; 8(9). PMID: 24023916    Free PMC article.
GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells.
Emilie Gauthy, Julia Cuende, +6 authors, Sophie Lucas.
PLoS One, 2013 Oct 08; 8(9). PMID: 24098777    Free PMC article.
How numbers, nature, and immune status of foxp3(+) regulatory T-cells shape the early immunological events in tumor development.
Guillaume Darrasse-Jèze, Katrina Podsypanina.
Front Immunol, 2013 Oct 18; 4. PMID: 24133490    Free PMC article.
Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics.
Kalet León, Karina García-Martínez, Tania Carmenate.
Front Immunol, 2014 Jan 01; 4. PMID: 24376444    Free PMC article.
The immunoregulatory role of type I and type II NKT cells in cancer and other diseases.
Masaki Terabe, Jay A Berzofsky.
Cancer Immunol Immunother, 2014 Jan 05; 63(3). PMID: 24384834    Free PMC article.
C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.
Ida Christine Norrie, Ewa Ohlsson, +2 authors, Bo T Porse.
PLoS One, 2014 Jan 10; 9(1). PMID: 24404186    Free PMC article.
Th17 cells and Tregs: unlikely allies.
Xin Chen, Joost J Oppenheim.
J Leukoc Biol, 2014 Feb 25; 95(5). PMID: 24563509    Free PMC article.
Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy.
David Escors.
New J Sci, 2014 Mar 19; 2014. PMID: 24634791    Free PMC article.
Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.
Kate S Smigiel, Shivani Srivastava, J Michael Stolley, Daniel J Campbell.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712458    Free PMC article.
Highly Cited. Review.
Prognostic value of peripheral and local forkhead box P3+ regulatory T cells in patients with non-small-cell lung cancer.
Takeo Hasegawa, Hiroyuki Suzuki, +7 authors, Mitsukazu Gotoh.
Mol Clin Oncol, 2014 Jul 24; 2(5). PMID: 25054031    Free PMC article.
Antibody-based depletion of Foxp3+ T cells potentiates antitumor immune memory stimulated by mTOR inhibition.
Hyung L Kim.
Oncoimmunology, 2014 Aug 02; 3. PMID: 25083329    Free PMC article.
Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth.
Yuan Yin, Xing Cai, +19 authors, Chen-Yu Zhang.
Cell Res, 2014 Sep 17; 24(10). PMID: 25223704    Free PMC article.
Highly Cited.
Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy.
Shirin Karimi, Subhasis Chattopadhyay, Nitya G Chakraborty.
Immunology, 2014 Sep 23; 144(2). PMID: 25243729    Free PMC article.
Immune reaction and colorectal cancer: friends or foes?
Vincenzo Formica, Vittore Cereda, +2 authors, Mario Roselli.
World J Gastroenterol, 2014 Sep 26; 20(35). PMID: 25253941    Free PMC article.
Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state.
Miki Tongu, Nanae Harashima, +2 authors, Mamoru Harada.
Cancer Sci, 2014 Nov 05; 106(1). PMID: 25363339    Free PMC article.
Depletion of Foxp3+ Regulatory T Cells Promotes Profibrogenic Milieu of Cholestasis-Induced Liver Injury.
Yoon Seok Roh, Surim Park, Chae Woong Lim, Bumseok Kim.
Dig Dis Sci, 2014 Nov 25; 60(7). PMID: 25416630
Immune regulation of bone metastasis.
Aude-Hélène Capietto, Roberta Faccio.
Bonekey Rep, 2014 Dec 17; 3. PMID: 25512853    Free PMC article.
Immune-mediated antitumor effect by type 2 diabetes drug, metformin.
Shingo Eikawa, Mikako Nishida, +3 authors, Heiichiro Udono.
Proc Natl Acad Sci U S A, 2015 Jan 28; 112(6). PMID: 25624476    Free PMC article.
Highly Cited.
Results of multicenter double-blind placebo-controlled phase II clinical trial of Panagen preparation to evaluate its leukostimulatory activity and formation of the adaptive immune response in patients with stage II-IV breast cancer.
Anastasia S Proskurina, Tatiana S Gvozdeva, +18 authors, Mikhail A Shurdov.
BMC Cancer, 2015 Apr 18; 15. PMID: 25886605    Free PMC article.
The immune system in hepatocellular carcinoma and potential new immunotherapeutic strategies.
Gaetano Bertino, Shirin Demma, +9 authors, Michele Malaguarnera.
Biomed Res Int, 2015 Apr 22; 2015. PMID: 25893197    Free PMC article.
Targeting the innate immune system as immunotherapy for acute myeloid leukemia.
Emily Curran, Leticia Corrales, Justin Kline.
Front Oncol, 2015 Apr 29; 5. PMID: 25914882    Free PMC article.
Clinically feasible approaches to potentiating cancer cell-based immunotherapies.
V I Seledtsov, A G Goncharov, G V Seledtsova.
Hum Vaccin Immunother, 2015 May 02; 11(4). PMID: 25933181    Free PMC article.
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Christel Devaud, Jennifer A Westwood, +6 authors, Michael H Kershaw.
Oncoimmunology, 2015 May 06; 3(11). PMID: 25941590    Free PMC article.
Regulatory T cells turn pathogenic.
Jitao Guo, Xuyu Zhou.
Cell Mol Immunol, 2015 May 06; 12(5). PMID: 25942597    Free PMC article.
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity.
Alice O Kamphorst, Koichi Araki, Rafi Ahmed.
Vaccine, 2015 May 30; 33 Suppl 2. PMID: 26022562    Free PMC article.
T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it?
Florian Anzengruber, Pinar Avci, Lucas Freitas de Freitas, Michael R Hamblin.
Photochem Photobiol Sci, 2015 Jun 13; 14(8). PMID: 26062987    Free PMC article.
Highly clonal regulatory T-cell population in follicular lymphoma - inverse correlation with the diversity of CD8+ T cells.
Xiao Liu, Girish Venkataraman, +5 authors, Justin Kline.
Oncoimmunology, 2015 Jul 15; 4(5). PMID: 26155390    Free PMC article.
Protective Effect of CXCR3⁺CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells in Renal Ischemia-Reperfusion Injury.
Cao Jun, Li Qingshu, +4 authors, Min Su.
Mediators Inflamm, 2015 Aug 15; 2015. PMID: 26273136    Free PMC article.
Immunosuppression associated with chronic inflammation in the tumor microenvironment.
Dingzhi Wang, Raymond N DuBois.
Carcinogenesis, 2015 Sep 12; 36(10). PMID: 26354776    Free PMC article.
Highly Cited. Review.
Emerging strategies for cancer immunoprevention.
J C Roeser, S D Leach, F McAllister.
Oncogene, 2015 Sep 15; 34(50). PMID: 26364615
Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.
Wendy Wj Unger, Christian T Mayer, +9 authors, Yvette van Kooyk.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405564    Free PMC article.
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
Alan Serrels, Tom Lund, +15 authors, Margaret C Frame.
Cell, 2015 Sep 26; 163(1). PMID: 26406376    Free PMC article.
Highly Cited.
Clinical significance of expanded Foxp3⁺ Helios⁻ regulatory T cells in patients with non-small cell lung cancer.
Satoshi Muto, Yuki Owada, +11 authors, Mitsukazu Gotoh.
Int J Oncol, 2015 Oct 16; 47(6). PMID: 26460798    Free PMC article.
Accumulation of Regulatory T Cells and Chronic Inflammation in the Middle Ear in a Mouse Model of Chronic Otitis Media with Effusion Induced by Combined Eustachian Tube Blockage and Nontypeable Haemophilus influenzae Infection.
Takashi Hirano, Satoru Kodama, Toshiaki Kawano, Masashi Suzuki.
Infect Immun, 2015 Nov 11; 84(1). PMID: 26553466    Free PMC article.
Effects of radiation on T regulatory cells in normal states and cancer: mechanisms and clinical implications.
Shu Liu, Xiangdong Sun, +5 authors, Xinchen Sun.
Am J Cancer Res, 2016 Jan 26; 5(11). PMID: 26807310    Free PMC article.
Roles of regulatory T cells in cancer immunity.
Yoshiko Takeuchi, Hiroyoshi Nishikawa.
Int Immunol, 2016 May 11; 28(8). PMID: 27160722    Free PMC article.
Highly Cited. Review.
Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells.
Nicolas Goudin, Pascal Chappert, +3 authors, Orly Azogui.
PLoS One, 2016 Jun 25; 11(6). PMID: 27341421    Free PMC article.
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade.
Wei Xue, Rachael L Metheringham, +5 authors, Lindy G Durrant.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471648    Free PMC article.
TGF-β and VEGF cooperatively control the immunotolerant tumor environment and the efficacy of cancer immunotherapies.
Tristan Courau, Djamel Nehar-Belaid, +5 authors, David Klatzmann.
JCI Insight, 2016 Oct 05; 1(9). PMID: 27699271    Free PMC article.
Friend or foe? Mogamulizumab in allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma.
Shigeo Fuji, Takero Shindo.
Stem Cell Investig, 2016 Nov 22; 3. PMID: 27868052    Free PMC article.
Potential applications of nanoparticles in cancer immunotherapy.
Yimei Jia, Abdelwahab Omri, Lakshmi Krishnan, Michael J McCluskie.
Hum Vaccin Immunother, 2016 Nov 22; 13(1). PMID: 27870598    Free PMC article.
Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study.
H Raza Ali, Leon Chlon, +2 authors, Carlos Caldas.
PLoS Med, 2016 Dec 14; 13(12). PMID: 27959923    Free PMC article.
Highly Cited.
Regulatory T cells in cancer immunotherapy.
Atsushi Tanaka, Shimon Sakaguchi.
Cell Res, 2016 Dec 21; 27(1). PMID: 27995907    Free PMC article.
Highly Cited. Review.
Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells.
Vinodh Kannappan, Kate Butcher, +3 authors, Kesley Attridge.
Cancer Immunol Immunother, 2017 Feb 28; 66(5). PMID: 28239749    Free PMC article.
Transient Treg depletion enhances therapeutic anti-cancer vaccination.
Scott A Fisher, Wayne J Aston, +11 authors, Richard A Lake.
Immun Inflamm Dis, 2017 Mar 03; 5(1). PMID: 28250921    Free PMC article.
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Frederick Arce Vargas, Andrew J S Furness, +29 authors, Sergio A Quezada.
Immunity, 2017 Apr 16; 46(4). PMID: 28410988    Free PMC article.
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Exendin-4 Exhibits Enhanced Anti-tumor Effects in Diabetic Mice.
Lan He, Priscilla T Y Law, +2 authors, Paul K S Chan.
Sci Rep, 2017 May 13; 7(1). PMID: 28496193    Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
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Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer.
Baodan Yu, Junli Wang, +8 authors, Jun Xu.
Exp Ther Med, 2017 Jul 05; 14(1). PMID: 28673007    Free PMC article.
CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer.
Fee Bengsch, Dawson M Knoblock, +2 authors, Gregory L Beatty.
Cancer Immunol Immunother, 2017 Sep 01; 66(12). PMID: 28856392    Free PMC article.
Colorectal cancer-infiltrating T lymphocytes display a distinct chemokine receptor expression profile.
Ann-Britt Löfroos, Mohammad Kadivar, Sabina Resic Lindehammer, Jan Marsal.
Eur J Med Res, 2017 Oct 13; 22(1). PMID: 29020986    Free PMC article.
Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug.
Yuki Kunisada, Shingo Eikawa, +7 authors, Heiichiro Udono.
EBioMedicine, 2017 Oct 27; 25. PMID: 29066174    Free PMC article.
CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy.
Anna Wasiuk, James Testa, +9 authors, Li-Zhen He.
J Immunol, 2017 Nov 08; 199(12). PMID: 29109120    Free PMC article.
Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity.
Christophe Pedros, Ann J Canonigo-Balancio, Kok-Fai Kong, Amnon Altman.
JCI Insight, 2017 Dec 08; 2(23). PMID: 29212947    Free PMC article.
Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells.
Martin Y Fan, Laurence A Turka.
Front Immunol, 2018 Feb 13; 9. PMID: 29434595    Free PMC article.
The Abscopal Effect in the Era of Cancer Immunotherapy: a Spontaneous Synergism Boosting Anti-tumor Immunity?
Zuzana Hlavata, Cinzia Solinas, +4 authors, Mario Scartozzi.
Target Oncol, 2018 Feb 23; 13(2). PMID: 29470785
Tumor Necrosis Factor α and Regulatory T Cells in Oncoimmunology.
Benoît L Salomon, Mathieu Leclerc, +3 authors, José L Cohen.
Front Immunol, 2018 Mar 30; 9. PMID: 29593717    Free PMC article.
IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy.
Jianmin Zhu, Jin-Qing Liu, +11 authors, Xue-Feng Bai.
JCI Insight, 2018 Apr 06; 3(7). PMID: 29618655    Free PMC article.
Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation.
Van Ngo Thai Bich, Tsunaki Hongu, +6 authors, Yasunori Kanaho.
Sci Rep, 2018 Apr 21; 8(1). PMID: 29674728    Free PMC article.
Norcantharidin enhances antitumor immunity of GM-CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells.
Lijun Mo, Xinji Zhang, +6 authors, Zhiming Hu.
Cancer Sci, 2018 May 18; 109(7). PMID: 29770533    Free PMC article.
Differential Regulation of T-cell mediated anti-tumor memory and cross-protection against the same tumor in lungs versus skin.
Jessica J O'Konek, Elena Ambrosino, +5 authors, Jay A Berzofsky.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900040    Free PMC article.
Alteration of circulating natural autoantibodies to CD25-derived peptide antigens and FOXP3 in non-small cell lung cancer.
Huan Zhao, Xuan Zhang, +3 authors, Jun Wei.
Sci Rep, 2018 Jul 01; 8(1). PMID: 29959381    Free PMC article.
Treg Fragility: A Prerequisite for Effective Antitumor Immunity?
Abigail E Overacre-Delgoffe, Dario A A Vignali.
Cancer Immunol Res, 2018 Aug 03; 6(8). PMID: 30068755    Free PMC article.
Complex interplay between tumor microenvironment and cancer therapy.
Minhong Shen, Yibin Kang.
Front Med, 2018 Aug 12; 12(4). PMID: 30097962
Differential Roles of IL-2 Signaling in Developing versus Mature Tregs.
Martin Y Fan, Jun Siong Low, +5 authors, Laurence A Turka.
Cell Rep, 2018 Nov 01; 25(5). PMID: 30380412    Free PMC article.
Effects of tumor metabolic microenvironment on regulatory T cells.
Yi-An Wang, Xiao-Ling Li, +13 authors, Wei Xiong.
Mol Cancer, 2018 Nov 28; 17(1). PMID: 30477520    Free PMC article.
A novel approach for rapid high-throughput selection of recombinant functional rat monoclonal antibodies.
Qin Chen, Shengping Qiu, +7 authors, Chenghao Huang.
BMC Immunol, 2018 Dec 06; 19(1). PMID: 30514214    Free PMC article.
Reduced GRAMD1C expression correlates to poor prognosis and immune infiltrates in kidney renal clear cell carcinoma.
Haiyan Hao, Ziheng Wang, +4 authors, Wei Wang.
PeerJ, 2019 Dec 26; 7. PMID: 31875150    Free PMC article.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Julianna Blagih, Fabio Zani, +13 authors, Karen H Vousden.
Cell Rep, 2020 Jan 16; 30(2). PMID: 31940491    Free PMC article.
Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms.
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Eur J Immunol, 2011 Jun 29; 41(10). PMID: 21710477    Free PMC article.
Effect of Apatinib on Serum CD4+CD25+ T cells, NK Cells, and T Cells Subgroup in Malignant Tumor.
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Technol Cancer Res Treat, 2020 Jan 01; 18. PMID: 31888413    Free PMC article.
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.
Atsushi Tanaka, Hiroyoshi Nishikawa, +19 authors, Shimon Sakaguchi.
J Exp Med, 2019 Nov 11; 217(2). PMID: 31704808    Free PMC article.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
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Proc Natl Acad Sci U S A, 2019 Apr 28; 116(20). PMID: 31028147    Free PMC article.
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Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis.
Tamer B Shabaneh, Aleksey K Molodtsov, +7 authors, Mary Jo Turk.
Cancer Res, 2018 Jul 22; 78(17). PMID: 30026331    Free PMC article.
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity.
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Proc Natl Acad Sci U S A, 2019 Feb 15; 116(10). PMID: 30760587    Free PMC article.
Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy.
Ee Lyn Lim, Klaus Okkenhaug.
Immunology, 2019 May 21; 157(3). PMID: 31107985    Free PMC article.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy.
Jung-Ho Kim, Beom Seok Kim, Sang-Kyou Lee.
Immune Netw, 2020 Mar 12; 20(1). PMID: 32158592    Free PMC article.
Mechanisms of human FoxP3+ Treg cell development and function in health and disease.
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Clin Exp Immunol, 2019 Mar 14; 197(1). PMID: 30864147    Free PMC article.
The multifaceted Foxp3fgfp allele enhances spontaneous and therapeutic immune surveillance of cancer in mice.
José Almeida-Santos, Marie-Louise Bergman, +3 authors, Jocelyne Demengeot.
Eur J Immunol, 2019 Nov 16; 50(3). PMID: 31729760    Free PMC article.
Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy.
Afsheen Raza, Maysaloun Merhi, +4 authors, Said Dermime.
J Transl Med, 2020 Mar 30; 18(1). PMID: 32220256    Free PMC article.
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts.
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Cancer Discov, 2019 Jun 15; 9(8). PMID: 31197017    Free PMC article.
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Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges.
Ilenia Pacella, Silvia Piconese.
Front Immunol, 2019 Sep 12; 10. PMID: 31507585    Free PMC article.
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
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Cancer Sci, 2019 May 19; 110(7). PMID: 31102428    Free PMC article.
Highly Cited. Review.
Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells.
SeongJun Han, Douglas C Chung, +6 authors, Pamela S Ohashi.
Oncoimmunology, 2020 Apr 22; 9(1). PMID: 32313719    Free PMC article.
Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy.
Michael J Gough, Shay Sharon, Marka R Crittenden, Kristina H Young.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381295    Free PMC article.
Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity - A Mini-Review.
Weikan Wang, Rachel Thomas, Olga Sizova, Dong-Ming Su.
Front Immunol, 2020 May 20; 11. PMID: 32425946    Free PMC article.
Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia.
Yuling Wan, Congxiao Zhang, +8 authors, Jianxiang Wang.
BMC Cancer, 2020 May 28; 20(1). PMID: 32456622    Free PMC article.
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.
Rodolfo Daniel Cervantes-Villagrana, Damaris Albores-García, Alberto Rafael Cervantes-Villagrana, Sara Judit García-Acevez.
Signal Transduct Target Ther, 2020 Jun 20; 5(1). PMID: 32555170    Free PMC article.
Detection of circulating natural antibodies against CD25, MUC1, and VEGFR1 for early diagnosis of non-small cell lung cancer.
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FEBS Open Bio, 2020 May 12; 10(7). PMID: 32392378    Free PMC article.
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression.
Monika Sharma, Martin P Schlegel, +15 authors, Kathryn J Moore.
Circ Res, 2020 Apr 28; 127(3). PMID: 32336197    Free PMC article.
The Effect of Antibody Fragments on CD25 Targeted Regulatory T Cell Near-Infrared Photoimmunotherapy.
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Bioconjug Chem, 2019 Sep 10; 30(10). PMID: 31498995    Free PMC article.
Increase in CD4+FOXP3+ regulatory T cell number and upregulation of the HGF/c-Met signaling pathway during the liver metastasis of colorectal cancer.
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Oncol Lett, 2020 Aug 13; 20(3). PMID: 32782528    Free PMC article.
Tregs, Helios and tumor immunity: the sun has not yet risen.
Angela M Thornton, Ethan M Shevach.
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Regulatory T Cells in Gynecologic Cancer.
Yang Ou, Martin J Cannon, Mayumi Nakagawa.
MOJ Immunol, 2019 Jan 15; 6(2). PMID: 30637330    Free PMC article.
Sudachitin, polymethoxyflavone from Citrus sudachi, enhances antigen-specific cellular and humoral immune responses in BALB/c mice.
Mami Mitani, Yuki Minatogawa, +4 authors, Tohru Sakai.
J Clin Biochem Nutr, 2019 Apr 03; 64(2). PMID: 30936628    Free PMC article.
Turning the Tide Against Regulatory T Cells.
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Front Oncol, 2019 May 07; 9. PMID: 31058083    Free PMC article.
Therapy with CD4+CD25+ T regulatory cells - should we be afraid of cancer?
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Contemp Oncol (Pozn), 2019 May 08; 23(1). PMID: 31061630    Free PMC article.
Biomarkers for Immune Checkpoint Inhibitor-Mediated Tumor Response and Adverse Events.
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Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting?
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Cancers (Basel), 2020 Nov 05; 12(11). PMID: 33143070    Free PMC article.
CD25 Blockade Delays Regulatory T Cell Reconstitution and Does Not Prevent Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation.
Frederick L Locke, Joseph Pidala, +14 authors, Claudio Anasetti.
Biol Blood Marrow Transplant, 2016 Dec 23; 23(3). PMID: 28007665    Free PMC article.
Cellular constituents of immune escape within the tumor microenvironment.
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How Does an Anti-CTLA-4 Antibody Promote Cancer Immunity?
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Trends Immunol, 2018 Dec 01; 39(12). PMID: 30497614    Free PMC article.
Microbiota: Overview and Implication in Immunotherapy-Based Cancer Treatments.
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Int J Mol Sci, 2019 Jun 05; 20(11). PMID: 31159348    Free PMC article.
CD4+CD25+ Cells Are Essential for Maintaining Immune Tolerance in Chickens Inoculated with Bovine Serum Albumin at the Late Stage of Embryonic Development.
Xiaoxue Yu, Yufang Meng, +3 authors, Zandong Li.
Vet Sci, 2020 Oct 08; 7(4). PMID: 33022909    Free PMC article.
Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators.
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Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816    Free PMC article.
Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy.
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Sci Transl Med, 2016 Aug 19; 8(352). PMID: 27535621    Free PMC article.
Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy.
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Cancers (Basel), 2020 Dec 31; 13(1). PMID: 33375291    Free PMC article.
Domain binding and isotype dictate the activity of anti-human OX40 antibodies.
Jordana Griffiths, Khiyam Hussain, +18 authors, Mark S Cragg.
J Immunother Cancer, 2021 Jan 12; 8(2). PMID: 33428585    Free PMC article.
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy.
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Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities.
Fatemeh Bayati, Mahsa Mohammadi, +3 authors, Ehsan Sharif-Paghaleh.
Front Immunol, 2021 Feb 02; 11. PMID: 33519807    Free PMC article.
Front Line Applications and Future Directions of Immunotherapy in Small-Cell Lung Cancer.
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Cancers (Basel), 2021 Feb 13; 13(3). PMID: 33572705    Free PMC article.
CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity.
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Nat Cancer, 2021 Mar 02; 1(12). PMID: 33644766    Free PMC article.
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy.
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J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589525    Free PMC article.
The Impact of Tregs on the Anticancer Immunity and the Efficacy of Immune Checkpoint Inhibitor Therapies.
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Front Immunol, 2021 Mar 16; 12. PMID: 33717139    Free PMC article.
Protective low-avidity anti-tumour CD8+ T cells are selectively attenuated by regulatory T cells.
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Immunother Adv, 2021 Mar 23; 1(1). PMID: 33748824    Free PMC article.
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.
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Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809974    Free PMC article.
Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.
Yingjie Nie, Jiang He, +5 authors, Xin Chen.
Sci Signal, 2018 Jan 04; 11(511). PMID: 29295954    Free PMC article.
Regulatory T Cells as an Escape Mechanism to the Immune Response in Taenia crassiceps Infection.
Laura Adalid-Peralta, Alexander Lopez-Roblero, +15 authors, Edgar E Sevilla-Reyes.
Front Cell Infect Microbiol, 2021 May 01; 11. PMID: 33928043    Free PMC article.
Targeting regulatory T cells for improving cancer therapy: Challenges and prospects.
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Tumor-Derived Exosomes Enriched by miRNA-124 Promote Anti-tumor Immune Response in CT-26 Tumor-Bearing Mice.
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Front Med (Lausanne), 2021 May 15; 8. PMID: 33987190    Free PMC article.
Acute pharmacological degradation of Helios destabilizes regulatory T cells.
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Nat Chem Biol, 2021 May 27; 17(6). PMID: 34035522    Free PMC article.
A Novel CAR Expressing NK Cell Targeting CD25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers.
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Front Oncol, 2021 Jun 01; 11. PMID: 34055618    Free PMC article.
Regulatory T-Cells as an Emerging Barrier to Immune Checkpoint Inhibition in Lung Cancer.
Daniel R Principe, Lauren Chiec, Nisha A Mohindra, Hidayatullah G Munshi.
Front Oncol, 2021 Jun 19; 11. PMID: 34141625    Free PMC article.
L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma.
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Cancer Biol Med, 2021 Mar 13;. PMID: 33710805    Free PMC article.
Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment.
Ellen N Scott, Angela M Gocher, Creg J Workman, Dario A A Vignali.
Front Immunol, 2021 Jun 29; 12. PMID: 34177968    Free PMC article.
Resistance to immune checkpoint inhibitors in advanced gastro-oesophageal cancers.
Mark A Baxter, Fearghas Middleton, Hannah P Cagney, Russell D Petty.
Br J Cancer, 2021 Jul 08; 125(8). PMID: 34230609    Free PMC article.
Identification of Cancer Hub Gene Signatures Associated with Immune-Suppressive Tumor Microenvironment and Ovatodiolide as a Potential Cancer Immunotherapeutic Agent.
Jia-Hong Chen, Alexander T H Wu, +4 authors, Tsu-Yi Chao.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359748    Free PMC article.
Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study.
Dmitriy Zamarin, Omid Hamid, +6 authors, David S Hong.
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Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy.
Laura A Huppert, Michael D Green, +4 authors, James C Lee.
Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572    Free PMC article.
Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies.
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J Immunother Cancer, 2021 Aug 01; 9(7). PMID: 34330764    Free PMC article.
Aptamer-mediated transcriptional gene silencing of Fox p 3 inhibits regulatory T cells and potentiates antitumor response.
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Mol Ther Nucleic Acids, 2021 Aug 31; 25. PMID: 34457999    Free PMC article.
A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
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Current strategies in engaging oncolytic viruses with antitumor immunity.
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Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
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Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle.
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Front Immunol, 2021 Sep 21; 12. PMID: 34539668    Free PMC article.
Transient regulatory T-cell targeting triggers immune control of multiple myeloma and prevents disease progression.
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Leukemia, 2021 Sep 30; 36(3). PMID: 34584204    Free PMC article.
LncRNA MIAT Services as a Noninvasive Biomarker for Diagnosis and Correlated with Immune Infiltrates in Breast Cancer.
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Int J Womens Health, 2021 Oct 30; 13. PMID: 34712062    Free PMC article.
Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a.
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Elife, 2021 Nov 10; 10. PMID: 34751648    Free PMC article.
Postoperative Natural Killer Cell Dysfunction: The Prime Suspect in the Case of Metastasis Following Curative Cancer Surgery.
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Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34768810    Free PMC article.
Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity.
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Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies.
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Front Immunol, 2021 Dec 07; 12. PMID: 34868044    Free PMC article.
Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer.
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Front Oncol, 2021 Dec 07; 11. PMID: 34868991    Free PMC article.
Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab.
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Nat Commun, 2021 Dec 16; 12(1). PMID: 34907192    Free PMC article.
Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors.
Takuro Saito, Koji Kurose, +11 authors, Hisashi Wada.
Nagoya J Med Sci, 2021 Dec 18; 83(4). PMID: 34916725    Free PMC article.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial.
Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg.
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Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity.
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J Histochem Cytochem, 2021 Nov 10; 70(1). PMID: 34751050    Free PMC article.
Immunometabolism in biofilm infection: lessons from cancer.
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Mol Med, 2022 Jan 31; 28(1). PMID: 35093033    Free PMC article.
Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway.
Linzhi Han, Hongjie Shi, +9 authors, Yan Gong.
Front Oncol, 2022 Feb 04; 11. PMID: 35111682    Free PMC article.
How to kill Treg cells for immunotherapy.
Gavin I Ellis, James L Riley.
Nat Cancer, 2020 Dec 01; 1(12). PMID: 35121936
Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer.
Shingo Maeda, Tomoki Motegi, +8 authors, Yasuyuki Momoi.
J Immunother Cancer, 2022 Feb 09; 10(2). PMID: 35131860    Free PMC article.
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Yujiro Kidani, Wataru Nogami, +39 authors, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2022 Feb 11; 119(7). PMID: 35140181    Free PMC article.
A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia.
Agnieszka Goral, Malgorzata Firczuk, +15 authors, Angelika Muchowicz.
Front Immunol, 2022 Mar 18; 13. PMID: 35296093    Free PMC article.
Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders - Advances and challenges.
Tapas Kumar Goswami, Mithilesh Singh, +7 authors, Kuldeep Dhama.
Hum Vaccin Immunother, 2022 Mar 05; 18(1). PMID: 35240914    Free PMC article.
Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma.
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