Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
S Read, V Malmström, F Powrie.
J Exp Med, 2000 Jul 19; 192(2). PMID: 10899916 Free PMC article.
Highly Cited.
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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
T Takahashi, T Tagami, +5 authors, S Yamazaki, T Uede, J Shimizu, N Sakaguchi, T W Mak, S Sakaguchi. less
J Exp Med, 2000 Jul 19; 192(2). PMID: 10899917 Free PMC article.
Highly Cited.
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CD28, CTLA-4 and their ligands: who does what and to whom?
D M Sansom.
Immunology, 2000 Sep 30; 101(2). PMID: 11012769 Free PMC article.
Review.
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Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.
T J Sullivan, J J Letterio, +6 authors, A van Elsas, M Mamura, J van Amelsfort, S Sharpe, B Metzler, C A Chambers, J P Allison. less
Proc Natl Acad Sci U S A, 2001 Feb 28; 98(5). PMID: 11226283 Free PMC article.
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CD28 function: a balance of costimulatory and regulatory signals.
Hélène Bour-Jordan, Jeffrey A Blueston.
J Clin Immunol, 2002 Apr 18; 22(1). PMID: 11958588
Review.
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Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes.
S K Smyk-Pearson, A C Bakke, P K Held, R S Wildin.
Clin Exp Immunol, 2003 Jul 19; 133(2). PMID: 12869024 Free PMC article.
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Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation.
Laura L Carter, Beatriz M Carreno.
Immunol Res, 2003 Aug 30; 28(1). PMID: 12947224
Review.
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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.
Mindi R Walker, Deborah J Kasprowicz, +4 authors, Vivian H Gersuk, Angele Benard, Megan Van Landeghen, Jane H Buckner, Steven F Ziegler. less
J Clin Invest, 2003 Nov 05; 112(9). PMID: 14597769 Free PMC article.
Highly Cited.
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Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases.
Monika C Brunner-Weinzierl, Holger Hoff, Gerd-R Burmester.
Arthritis Res Ther, 2004 Apr 03; 6(2). PMID: 15059264 Free PMC article.
Review.
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Differential expression of CTLA-4 among T cell subsets.
C B Jago, J Yates, +2 authors, N Olsen Saraiva Câmara, R I Lechler, G Lombardi. less
Clin Exp Immunol, 2004 May 19; 136(3). PMID: 15147348 Free PMC article.
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Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
Chloe L Thio, Timothy L Mosbruger, +6 authors, Richard A Kaslow, Christopher L Karp, Steffanie A Strathdee, David Vlahov, Stephen J O'Brien, Jacquie Astemborski, David L Thomas. less
J Virol, 2004 Sep 29; 78(20). PMID: 15452244 Free PMC article.
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Function of tumor necrosis factor receptor family members on regulatory T-cells.
Robert H Arch.
Immunol Res, 2005 Aug 18; 32(1-3). PMID: 16106056
Review.
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Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.
Dirk Homann, Wolfgang Dummer, +4 authors, Tom Wolfe, Evelyn Rodrigo, Argyrios N Theofilopoulos, Michael B A Oldstone, Matthias G von Herrath. less
J Virol, 2005 Dec 15; 80(1). PMID: 16352552 Free PMC article.
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Checkpoint blockade in cancer immunotherapy.
Alan J Korman, Karl S Peggs, James P Allison.
Adv Immunol, 2006 May 30; 90. PMID: 16730267 Free PMC article.
Highly Cited. Review.
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CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.
Luca Gattinoni, Anju Ranganathan, +6 authors, Deborah R Surman, Douglas C Palmer, Paul A Antony, Marc R Theoret, David M Heimann, Steven A Rosenberg, Nicholas P Restifo. less
Blood, 2006 Aug 03; 108(12). PMID: 16882704 Free PMC article.
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Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Simon Read, Rebecca Greenwald, +5 authors, Ana Izcue, Nicholas Robinson, Didier Mandelbrot, Loise Francisco, Arlene H Sharpe, Fiona Powrie. less
J Immunol, 2006 Sep 20; 177(7). PMID: 16982872 Free PMC article.
Highly Cited.
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VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.
Lorenz Vogt, Nicole Schmitz, +10 authors, Michael O Kurrer, Monika Bauer, Heather I Hinton, Silvia Behnke, Dominique Gatto, Peter Sebbel, Roger R Beerli, Ivo Sonderegger, Manfred Kopf, Philippe Saudan, Martin F Bachmann. less
J Clin Invest, 2006 Oct 04; 116(10). PMID: 17016562 Free PMC article.
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Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
Yong Zheng, Claire N Manzotti, +4 authors, Fiona Burke, Laure Dussably, Omar Qureshi, Lucy S K Walker, David M Sansom. less
J Immunol, 2008 Jul 22; 181(3). PMID: 18641304 Free PMC article.
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Peripherally induced Treg: mode, stability, and role in specific tolerance.
Irina Apostolou, Panos Verginis, +3 authors, Karsten Kretschmer, Julia Polansky, Jochen Hühn, Harald von Boehmer. less
J Clin Immunol, 2008 Oct 09; 28(6). PMID: 18841451
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CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Josef Kurtz, Forum Raval, +2 authors, Casey Vallot, Jayden Der, Megan Sykes. less
Blood, 2009 Jan 31; 113(15). PMID: 19179471 Free PMC article.
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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Randall H Friedline, David S Brown, +7 authors, Hai Nguyen, Hardy Kornfeld, Jinhee Lee, Yi Zhang, Mark Appleby, Sandy D Der, Joonsoo Kang, Cynthia A Chambers. less
J Exp Med, 2009 Feb 04; 206(2). PMID: 19188497 Free PMC article.
Highly Cited.
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Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.
Hélène Bour-Jordan, Jeffrey A Bluestone.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426214 Free PMC article.
Review.
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CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation.
Dorothy K Sojka, Angela Hughson, Deborah J Fowell.
Eur J Immunol, 2009 May 23; 39(6). PMID: 19462377 Free PMC article.
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Molecular orchestration of differentiation and function of regulatory T cells.
Li-Fan Lu, Alexander Rudensky.
Genes Dev, 2009 Jun 03; 23(11). PMID: 19487568 Free PMC article.
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Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Karl S Peggs, Sergio A Quezada, +2 authors, Cynthia A Chambers, Alan J Korman, James P Allison. less
J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407 Free PMC article.
Highly Cited.
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CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
Wataru Ise, Masako Kohyama, +5 authors, Katherine M Nutsch, Hyang Mi Lee, Anish Suri, Emil R Unanue, Theresa L Murphy, Kenneth M Murphy. less
Nat Immunol, 2009 Dec 29; 11(2). PMID: 20037585 Free PMC article.
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Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells.
Alison M Paterson, Arlene H Sharpe.
Nat Immunol, 2010 Jan 20; 11(2). PMID: 20084066 Free PMC article.
Review.
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B7 family molecules as regulators of the maternal immune system in pregnancy.
Margaret G Petroff, Antoine Perchellet.
Am J Reprod Immunol, 2010 Apr 14; 63(6). PMID: 20384620 Free PMC article.
Review.
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Modulation of CTLA-4 and GITR for cancer immunotherapy.
Francesca Avogadri, Jianda Yuan, +2 authors, Arvin Yang, David Schaer, Jedd D Wolchok. less
Curr Top Microbiol Immunol, 2010 Jun 22; 344. PMID: 20563707 Free PMC article.
Review.
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Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.
Margaret K Callahan, Jedd D Wolchok, James P Allison.
Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074063 Free PMC article.
Review.
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PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.
Taku Okazaki, Il-mi Okazaki, +9 authors, Jian Wang, Daisuke Sugiura, Fumio Nakaki, Taku Yoshida, Yu Kato, Sidonia Fagarasan, Masamichi Muramatsu, Tomoo Eto, Kyoji Hioki, Tasuku Honjo. less
J Exp Med, 2011 Feb 09; 208(2). PMID: 21300912 Free PMC article.
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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, Kyoko Nakamura, Kesley Attridge, Claire Manzotti, Emily M Schmidt, Jennifer Baker, Louisa E Jeffery, Satdip Kaur, Zoe Briggs, Tie Z Hou, Clare E Futter, Graham Anderson, Lucy S K Walker, David M Sansom. less
Science, 2011 Apr 09; 332(6029). PMID: 21474713 Free PMC article.
Highly Cited.
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Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Marc Martinez-Llordella, Cristina Penaranda, Melanie Stumpf, Jeffrey A Bluestone. less
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898 Free PMC article.
Highly Cited. Review.
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Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).
Derek V Chan, Ally-Khan Somani, +7 authors, Andrew B Young, Jessica V Massari, Jennifer Ohtola, Hideaki Sugiyama, Edina Garaczi, Denise Babineau, Kevin D Cooper, Thomas S McCormick. less
BMC Biochem, 2011 May 28; 12. PMID: 21615933 Free PMC article.
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Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells.
Pei-Min Chen, Men-Luh Yen, +2 authors, Ko-Jiunn Liu, Huey-Kang Sytwu, B-Linju Yen. less
J Biomed Sci, 2011 Jul 19; 18. PMID: 21762539 Free PMC article.
Review.
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Regulatory T cell: a protection for tumour cells.
Yi Wang, Yushui Ma, +4 authors, Ying Fang, Shengdi Wu, Lili Liu, Da Fu, Xizhong Shen. less
J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966 Free PMC article.
Review.
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The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Lucy S K Walker, David M Sansom.
Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087
Highly Cited.
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Regulatory T cells: mechanisms of differentiation and function.
Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781 Free PMC article.
Highly Cited. Review.
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Molecular mechanisms of treg-mediated T cell suppression.
Angelika Schmidt, Nina Oberle, Peter H Krammer.
Front Immunol, 2012 May 09; 3. PMID: 22566933 Free PMC article.
Highly Cited.
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Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities.
Florencia Paula Madorsky-Rowdo, María Laura Lacreu, José Mordoh.
Front Immunol, 2012 May 09; 3. PMID: 22566975 Free PMC article.
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Boosting regulatory T cell function by CD4 stimulation enters the clinic.
Christian Becker, Tobias Bopp, Helmut Jonuleit.
Front Immunol, 2012 Jun 22; 3. PMID: 22719741 Free PMC article.
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Immune checkpoints in central nervous system autoimmunity.
Nicole Joller, Anneli Peters, Ana C Anderson, Vijay K Kuchroo.
Immunol Rev, 2012 Jun 26; 248(1). PMID: 22725958 Free PMC article.
Review.
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Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
Chun Jing Wang, Rupert Kenefeck, +6 authors, Lukasz Wardzinski, Kesley Attridge, Claire Manzotti, Emily M Schmidt, Omar S Qureshi, David M Sansom, Lucy S K Walker. less
J Immunol, 2012 Jul 04; 189(3). PMID: 22753931 Free PMC article.
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Multiple treg suppressive modules and their adaptability.
James B Wing, Shimon Sakaguchi.
Front Immunol, 2012 Jul 04; 3. PMID: 22754556 Free PMC article.
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CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
M J Barnes, T Griseri, +3 authors, A M F Johnson, W Young, F Powrie, A Izcue. less
Mucosal Immunol, 2012 Aug 23; 6(2). PMID: 22910217 Free PMC article.
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FOXO transcription factors throughout T cell biology.
Stephen M Hedrick, Rodrigo Hess Michelini, +2 authors, Andrew L Doedens, Ananda W Goldrath, Erica L Stone. less
Nat Rev Immunol, 2012 Aug 25; 12(9). PMID: 22918467 Free PMC article.
Highly Cited. Review.
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At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198 Free PMC article.
Highly Cited. Review.
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Treg and CTLA-4: two intertwining pathways to immune tolerance.
Lucy S K Walker.
J Autoimmun, 2013 Jul 16; 45. PMID: 23849743 Free PMC article.
Highly Cited. Review.
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CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β.
Christine M Deppong, Traci L Bricker, +3 authors, Brandy D Rannals, Nico Van Rooijen, Chyi-Song Hsieh, Jonathan M Green. less
J Immunol, 2013 Aug 21; 191(6). PMID: 23956428 Free PMC article.
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A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.
Taku Okazaki, Shunsuke Chikuma, +2 authors, Yoshiko Iwai, Sidonia Fagarasan, Tasuku Honjo. less
Nat Immunol, 2013 Nov 19; 14(12). PMID: 24240160
Highly Cited. Review.
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FOXP3 is a direct target of miR15a/16 in umbilical cord blood regulatory T cells.
X Liu, S N Robinson, +14 authors, T Setoyama, S S Tung, L D'Abundo, M Y Shah, H Yang, E Yvon, N Shah, H Yang, M Konopleva, G Garcia-Manero, I McNiece, K Rezvani, G A Calin, E J Shpall, S Parmar. less
Bone Marrow Transplant, 2014 Apr 09; 49(6). PMID: 24710569 Free PMC article.
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A VISTA on PD-1H.
Yang Liu.
J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743142 Free PMC article.
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Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Desirée Schubert, Claudia Bode, +37 authors, Rupert Kenefeck, Tie Zheng Hou, James B Wing, Alan Kennedy, Alla Bulashevska, Britt-Sabina Petersen, Alejandro A Schäffer, Björn A Grüning, Susanne Unger, Natalie Frede, Ulrich Baumann, Torsten Witte, Reinhold E Schmidt, Gregor Dueckers, Tim Niehues, Suranjith Seneviratne, Maria Kanariou, Carsten Speckmann, Stephan Ehl, Anne Rensing-Ehl, Klaus Warnatz, Mirzokhid Rakhmanov, Robert Thimme, Peter Hasselblatt, Florian Emmerich, Toni Cathomen, Rolf Backofen, Paul Fisch, Maximilian Seidl, Annette May, Annette Schmitt-Graeff, Shinji Ikemizu, Ulrich Salzer, Andre Franke, Shimon Sakaguchi, Lucy S K Walker, David M Sansom, Bodo Grimbacher. less
Nat Med, 2014 Oct 21; 20(12). PMID: 25329329 Free PMC article.
Highly Cited.
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Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.
Helga Schneider, Christopher E Rudd.
Front Immunol, 2014 Dec 30; 5. PMID: 25538704 Free PMC article.
Review.
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Confusing signals: recent progress in CTLA-4 biology.
Lucy S K Walker, David M Sansom.
Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039 Free PMC article.
Highly Cited. Review.
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A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.
Tie Zheng Hou, Omar S Qureshi, +4 authors, Chun Jing Wang, Jennifer Baker, Stephen P Young, Lucy S K Walker, David M Sansom. less
J Immunol, 2015 Jan 30; 194(5). PMID: 25632005 Free PMC article.
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Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients.
Emanuela Romano, Monika Kusio-Kobialka, +7 authors, Periklis G Foukas, Petra Baumgaertner, Christiane Meyer, Pierluigi Ballabeni, Olivier Michielin, Benjamin Weide, Pedro Romero, Daniel E Speiser. less
Proc Natl Acad Sci U S A, 2015 Apr 29; 112(19). PMID: 25918390 Free PMC article.
Highly Cited.
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Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.
Holly A Bolton, Erhua Zhu, +9 authors, Alexandra M Terry, Thomas V Guy, Woon-Puay Koh, Sioh-Yang Tan, Carl A Power, Patrick Bertolino, Katharina Lahl, Tim Sparwasser, Elena Shklovskaya, Barbara Fazekas de St Groth. less
J Clin Invest, 2015 Aug 25; 125(9). PMID: 26301814 Free PMC article.
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Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M Paterson, Scott B Lovitch, +9 authors, Peter T Sage, Vikram R Juneja, Youjin Lee, Justin D Trombley, Carolina V Arancibia-Cárcamo, Raymond A Sobel, Alexander Y Rudensky, Vijay K Kuchroo, Gordon J Freeman, Arlene H Sharpe. less
J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185 Free PMC article.
Highly Cited.
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Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.
Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, Kajsa Wing.
Proc Natl Acad Sci U S A, 2016 Apr 14; 113(17). PMID: 27071130 Free PMC article.
Highly Cited.
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Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Frank A Schildberg, Sarah R Klein, Gordon J Freeman, Arlene H Sharpe.
Immunity, 2016 May 19; 44(5). PMID: 27192563 Free PMC article.
Highly Cited. Review.
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CD28 co-stimulation in T-cell homeostasis: a recent perspective.
Niklas Beyersdorf, Thomas Kerkau, Thomas Hünig.
Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471717 Free PMC article.
Review.
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Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function.
Maria Sophia Mackroth, Annemieke Abel, +2 authors, Christiane Steeg, Julian Schulze Zur Wiesch, Thomas Jacobs. less
PLoS Pathog, 2016 Nov 02; 12(11). PMID: 27802341 Free PMC article.
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Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Tie Zheng Hou, Nisha Verma, +17 authors, Jennifer Wanders, Alan Kennedy, Blagoje Soskic, Daniel Janman, Neil Halliday, Behzad Rowshanravan, Austen Worth, Waseem Qasim, Helen Baxendale, Hans Stauss, Suranjith Seneviratne, Olaf Neth, Peter Olbrich, Sophie Hambleton, Peter D Arkwright, Siobhan O Burns, Lucy S K Walker, David M Sansom. less
Blood, 2017 Feb 06; 129(11). PMID: 28159733 Free PMC article.
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Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.
Rebecca L Crepeau, Mandy L Ford.
Expert Opin Biol Ther, 2017 May 21; 17(8). PMID: 28525959 Free PMC article.
Review.
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Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations.
N Verma, S O Burns, L S K Walker, D M Sansom.
Clin Exp Immunol, 2017 Jun 11; 190(1). PMID: 28600865 Free PMC article.
Review.
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A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy.
Xuexiang Du, Fei Tang, +14 authors, Mingyue Liu, Juanjuan Su, Yan Zhang, Wei Wu, Martin Devenport, Christopher A Lazarski, Peng Zhang, Xu Wang, Peiying Ye, Changyu Wang, Eugene Hwang, Tinghui Zhu, Ting Xu, Pan Zheng, Yang Liu. less
Cell Res, 2018 Feb 24; 28(4). PMID: 29472691 Free PMC article.
Highly Cited.
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Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells.
Niloufar Safinia, Nathali Grageda, +5 authors, Cristiano Scottà, Sarah Thirkell, Laura J Fry, Trishan Vaikunthanathan, Robert I Lechler, Giovanna Lombardi. less
Front Immunol, 2018 Mar 15; 9. PMID: 29535728 Free PMC article.
Review.
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Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Sara M Tolaney, F Stephen Hodi, Ursula B Kaiser, Le Min. less
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160 Free PMC article.
Review.
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Characterization of CTLA4 Trafficking and Implications for Its Function.
Sahamoddin Khailaie, Behzad Rowshanravan, +6 authors, Philippe A Robert, Erin Waters, Neil Halliday, Jesus David Badillo Herrera, Lucy S K Walker, David M Sansom, Michael Meyer-Hermann. less
Biophys J, 2018 Sep 17; 115(7). PMID: 30219287 Free PMC article.
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CTLA-4: a moving target in immunotherapy.
Behzad Rowshanravan, Neil Halliday, David M Sansom.
Blood, 2017 Nov 10; 131(1). PMID: 29118008 Free PMC article.
Highly Cited. Review.
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Development of immune checkpoint therapy for cancer.
Jill M Fritz, Michael J Lenardo.
J Exp Med, 2019 May 10; 216(6). PMID: 31068379 Free PMC article.
Highly Cited. Review.
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T cell costimulation, checkpoint inhibitors and anti-tumor therapy.
Dipankar Nandi, Sanmoy Pathak, +6 authors, Taru Verma, Madhulika Singh, Avik Chattopadhyay, Samriddhi Thakur, Abinaya Raghavan, Abhijeet Gokhroo, Vijayamahantesh. less
J Biosci, 2020 Apr 30; 45. PMID: 32345776
Review.
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Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer.
Clélia Coutzac, Jean-Mehdi Jouniaux, +22 authors, Angelo Paci, Julien Schmidt, Domenico Mallardo, Atmane Seck, Vahe Asvatourian, Lydie Cassard, Patrick Saulnier, Ludovic Lacroix, Paul-Louis Woerther, Aurore Vozy, Marie Naigeon, Laetitia Nebot-Bral, Mélanie Desbois, Ester Simeone, Christine Mateus, Lisa Boselli, Jonathan Grivel, Emilie Soularue, Patricia Lepage, Franck Carbonnel, Paolo Antonio Ascierto, Caroline Robert, Nathalie Chaput. less
Nat Commun, 2020 May 03; 11(1). PMID: 32358520 Free PMC article.
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Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy.
Yang Liu, Pan Zheng.
Trends Pharmacol Sci, 2019 Dec 15; 41(1). PMID: 31836191 Free PMC article.
Review.
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Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation.
Seungman Park, Yu Shi, +7 authors, Byoung Choul Kim, Myung Hyun Jo, Leilani O Cruz, Zheming Gou, Taekjip Ha, Li-Fan Lu, Daniel H Reich, Yun Chen. less
Biosens Bioelectron, 2020 Jul 31; 165. PMID: 32729511 Free PMC article.
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CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.
Navid Sobhani, Dana Rae Tardiel-Cyril, +3 authors, Aram Davtyan, Daniele Generali, Raheleh Roudi, Yong Li. less
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809974 Free PMC article.
Review.
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The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives.
Yifan Li, Lan Lu, +10 authors, Xu Wu, Qianxiu Li, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Zhangang Xiao, Zhigui Wu, Wei Hu, Chi Hin Cho, Mingxing Li. less
Int J Biol Sci, 2021 Aug 05; 17(11). PMID: 34345204 Free PMC article.
Review.
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Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells.
Murat Tekguc, James Badger Wing, +2 authors, Motonao Osaki, Jia Long, Shimon Sakaguchi. less
Proc Natl Acad Sci U S A, 2021 Jul 25; 118(30). PMID: 34301886 Free PMC article.
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Cytotoxic T lymphocyte antigen-4 regulates development of xenogenic graft versus host disease in mice via modulation of host immune responses induced by changes in human T cell engraftment and gene expression.
Chunxu Gao, Debra Gardner, +7 authors, Marie-Clare Theobalds, Shannon Hitchcock, Heather Deutsch, Chidozie Amuzie, Matteo Cesaroni, Davit Sargsyan, Tadimeti S Rao, Ravi Malaviya. less
Clin Exp Immunol, 2021 Sep 07; 206(3). PMID: 34487545 Free PMC article.
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Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
Review.
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