Journal Article
. 1999 Jul; 163(3):1128-31.

Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous

M F Bachmann 1 G Köhler  B Ecabert  T W Mak  M Kopf  
Affiliations
  • PMID: 10415006
  •     81 citations

Abstract

Mice deficient for the expression of CTLA-4 develop a lethal lymphoproliferative syndrome and multiorgan inflammation leading to death at about 4 wk of age. Here we show that RAG2-deficient mice reconstituted with CTLA-4-deficient bone marrow do not develop a lymphoproliferative syndrome despite lymphocyte infiltration mainly into pericardium and liver. Moreover, RAG2-deficient mice reconstituted with a mixture of normal and CTLA-4-deficient bone marrow remain healthy and do not develop any disease. Thus, the lethal disease observed in CTLA-4-deficient mice is not T cell autonomous and can be prevented by factors produced by normal T cells.

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