. 1999 Sep; 29(2):143-50.
doi: 10.1097/00004836-199909000-00008.

D-xylose testing

R M Craig 1 E D Ehrenpreis  
  • PMID: 10478874
  •     18 citations


The literature on D-xylose testing has been reviewed, stressing advances in our understanding of absorption in general (including D-xylose absorption), the relationship of D-xylose testing to the development of excellent serologic tests for the diagnosis of celiac disease, the use of D-xylose testing in the evaluation of diarrhea in acquired immunodeficiency syndrome, new information on breath testing for the evaluation of malabsorption, and recent information on the understanding of D-xylose absorption compared with transcellular vs. paracellular transport. The authors suggest ways in which D-xylose testing might be employed in malabsorption or diarrhea evaluations, including some algorithms.

Malabsorption testing: a review.
P M Ginsburg, P Janefalkar, D T Rubin, E D Ehrenpreis.
Curr Gastroenterol Rep, 2000 Sep 22; 2(5). PMID: 10998664
Small Intestinal Bacterial Overgrowth Syndrome.
Jeffery S. Meyers, Eli D. Ehrenpreis, Robert M. Craig.
Curr Treat Options Gastroenterol, 2001 Feb 15; 4(1). PMID: 11177677
Guidelines for the investigation of chronic diarrhoea, 2nd edition.
P D Thomas, A Forbes, +10 authors, G Brydon.
Gut, 2003 Jun 13; 52 Suppl 5. PMID: 12801941    Free PMC article.
Assessment of gastrointestinal function and response to megesterol acetate in subjects with gastrointestinal cancers and weight loss.
John Deutsch, J Fred Kolhouse.
Support Care Cancer, 2004 Apr 06; 12(7). PMID: 15064933
Assessment of intestinal permeability and absorption in cirrhotic patients with ascites using combined sugar probes.
Marc J Zuckerman, Ian S Menzies, +4 authors, Jesus A Hernandez.
Dig Dis Sci, 2004 Jun 10; 49(4). PMID: 15185867
Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome.
Robert W Chang, Patrick J Javid, +4 authors, Tom Jaksic.
Ann Surg, 2006 Jan 25; 243(2). PMID: 16432355    Free PMC article.
The serum D-xylose test as a useful tool to identify malabsorption in rats with antigen specific gut inflammatory reaction.
Danielle Mota Fontes Antunes, Janilda Pacheco da Costa, +5 authors, Gilberto Perez Cardoso.
Int J Exp Pathol, 2009 Apr 02; 90(2). PMID: 19335552    Free PMC article.
Accelerated gastric emptying but no carbohydrate malabsorption 1 year after gastric bypass surgery (GBP).
Gary Wang, Keesandra Agenor, +6 authors, Blandine Laferrère.
Obes Surg, 2012 Apr 25; 22(8). PMID: 22527599    Free PMC article.
The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease.
Phillipp Hartmann, Wei-Chung Chen, Bernd Schnabl.
Front Physiol, 2012 Oct 23; 3. PMID: 23087650    Free PMC article.
Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes.
Tongzhi Wu, Michelle J Bound, +5 authors, Christopher K Rayner.
Diabetes Care, 2013 Jan 30; 36(7). PMID: 23359361    Free PMC article.
ACG clinical guidelines: diagnosis and management of celiac disease.
Alberto Rubio-Tapia, Ivor D Hill, +3 authors, American College of Gastroenterology.
Am J Gastroenterol, 2013 Apr 24; 108(5). PMID: 23609613    Free PMC article.
Highly Cited.
Improvement and validation of d-xylose determination in urine and serum as a new tool for the noninvasive evaluation of lactase activity in humans.
Carmen Hermida, Oscar H Martínez-Costa, +9 authors, Juan J Aragón.
J Clin Lab Anal, 2014 Mar 25; 28(6). PMID: 24659338    Free PMC article.
Predisposing factors for positive D-Xylose breath test for evaluation of small intestinal bacterial overgrowth: a retrospective study of 932 patients.
Richard A Schatz, Qing Zhang, +3 authors, Baharak Moshiree.
World J Gastroenterol, 2015 Apr 29; 21(15). PMID: 25914466    Free PMC article.
The Surgical Approach to Short Bowel Syndrome - Autologous Reconstruction versus Transplantation.
Aparna Rege.
Viszeralmedizin, 2014 Jun 01; 30(3). PMID: 26288592    Free PMC article.
Chronic alcohol overconsumption may alter gut microbial metabolism: a retrospective study of 719 13C-D-xylose breath test results.
Steinar Traae Bjørkhaug, Viggo Skar, +3 authors, Jørgen Valeur.
Microb Ecol Health Dis, 2017 Jun 03; 28(1). PMID: 28572752    Free PMC article.
Impact of Xylose on Glucose-Dehydrogenase-Based Blood Glucose Meters for Patient Self-Testing.
Andreas Pfützner, Filiz Demircik, +3 authors, Sanja Ramljak.
J Diabetes Sci Technol, 2017 Jul 27; 11(3). PMID: 28745092    Free PMC article.
Analytical Validation of a New Enzymatic and Automatable Method for d-Xylose Measurement in Human Urine Samples.
Israel Sánchez-Moreno, Carmen Monsalve-Hernando, +8 authors, Carmen Hermida.
Biomed Res Int, 2017 Nov 18; 2017. PMID: 29147660    Free PMC article.
Safety of xylo-oligosaccharides (XOS) as a novel food pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Dominique Turck, +25 authors, Henk van Loveren.
EFSA J, 2018 Jul 23; 16(7). PMID: 32625993    Free PMC article.