Journal Article
. 1999 Sep; 11(2):141-51.
doi: 10.1016/s1074-7613(00)80089-8.

Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

H Nishimura 1 M Nose  H Hiai  N Minato  T Honjo  
  • PMID: 10485649
  •     897 citations


PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-based inhibitory motif, is induced in lymphocytes and monocytic cells following activation. Aged C57BL/6(B6)-PD-1(-/-) congenic mice spontaneously developed characteristic lupus-like proliferative arthritis and glomerulonephritis with predominant IgG3 deposition, which were markedly accelerated by introduction of a Fas mutation (lpr). Introduction of a PD-1 null mutation into the 2C-TCR (anti-H-2Ld) transgenic mice of the H-2(b/d) background resulted in the chronic and systemic graft-versus-host-like disease. Furthermore, CD8+ 2C-TCR+ PD-1(-/-) T cells exhibited markedly augmented proliferation in vitro in response to H-2d allogenic cells. Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses.

Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice.
H Nishimura, T Honjo, N Minato.
J Exp Med, 2000 Mar 08; 191(5). PMID: 10704469    Free PMC article.
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
G J Freeman, A J Long, +16 authors, T Honjo.
J Exp Med, 2000 Oct 04; 192(7). PMID: 11015443    Free PMC article.
Highly Cited.
Genetic remodeling of protein glycosylation in vivo induces autoimmune disease.
D Chui, G Sellakumar, +6 authors, J Marth.
Proc Natl Acad Sci U S A, 2001 Feb 07; 98(3). PMID: 11158608    Free PMC article.
Regulatory function of in vivo anergized CD4(+) T cells.
K Jooss, B Gjata, +2 authors, A Sarukhan.
Proc Natl Acad Sci U S A, 2001 Jul 05; 98(15). PMID: 11438696    Free PMC article.
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.
T Okazaki, A Maeda, +2 authors, T Honjo.
Proc Natl Acad Sci U S A, 2001 Nov 08; 98(24). PMID: 11698646    Free PMC article.
Highly Cited.
Activation and inhibition of lymphocytes by costimulation.
Kenneth A Frauwirth, Craig B Thompson.
J Clin Invest, 2002 Feb 06; 109(3). PMID: 11827987    Free PMC article.
Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells.
Michael J Eppihimer, Jason Gunn, +4 authors, John P Leonard.
Microcirculation, 2002 Apr 05; 9(2). PMID: 11932780    Free PMC article.
Highly Cited.
Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice.
Silvia Bolland, Young-Sun Yim, +2 authors, Jeffrey V Ravetch.
J Exp Med, 2002 May 08; 195(9). PMID: 11994421    Free PMC article.
Susceptibility genes in the pathogenesis of murine lupus.
Charles Nguyen, Nisha Limaye, Edward K Wakeland.
Arthritis Res, 2002 Jul 12; 4 Suppl 3. PMID: 12110145    Free PMC article.
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Yoshiko Iwai, Masayoshi Ishida, +3 authors, Nagahiro Minato.
Proc Natl Acad Sci U S A, 2002 Sep 10; 99(19). PMID: 12218188    Free PMC article.
Highly Cited.
Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.
Margaret L Hibbs, Kenneth W Harder, +5 authors, David M Tarlinton.
J Exp Med, 2002 Dec 18; 196(12). PMID: 12486102    Free PMC article.
Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.
Haidong Dong, Scott E Strome, +6 authors, Lieping Chen.
J Clin Invest, 2003 Feb 06; 111(3). PMID: 12569162    Free PMC article.
B cell inhibitory receptors and autoimmunity.
Nicholas R Pritchard, Kenneth G C Smith.
Immunology, 2003 Feb 27; 108(3). PMID: 12603592    Free PMC article.
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells.
P'ng Loke, James P Allison.
Proc Natl Acad Sci U S A, 2003 Apr 17; 100(9). PMID: 12697896    Free PMC article.
Highly Cited.
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.
Shengdian Wang, Jürgen Bajorath, +3 authors, Lieping Chen.
J Exp Med, 2003 Apr 30; 197(9). PMID: 12719480    Free PMC article.
B7-H1 pathway and its role in the evasion of tumor immunity.
Haidong Dong, Lieping Chen.
J Mol Med (Berl), 2003 May 02; 81(5). PMID: 12721664
A role for complement in feedback enhancement of antibody responses by IgG3.
Teresita Díaz de Ståhl, Jörgen Dahlstrom, Michael C Carroll, Birgitta Heyman.
J Exp Med, 2003 May 07; 197(9). PMID: 12732659    Free PMC article.
B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.
Xingluo Liu, Jian Xin Gao, +7 authors, Yang Liu.
J Exp Med, 2003 Jun 18; 197(12). PMID: 12810690    Free PMC article.
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
Tahiro Shin, Gene Kennedy, +8 authors, Franck Housseau.
J Exp Med, 2003 Jul 09; 198(1). PMID: 12847135    Free PMC article.
PD-1 inhibits antiviral immunity at the effector phase in the liver.
Yoshiko Iwai, Seigo Terawaki, +2 authors, Tasuku Honjo.
J Exp Med, 2003 Jul 09; 198(1). PMID: 12847136    Free PMC article.
Highly Cited.
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
Mohammed Javeed I Ansari, Alan D Salama, +9 authors, Mohamed H Sayegh.
J Exp Med, 2003 Jul 09; 198(1). PMID: 12847137    Free PMC article.
Highly Cited.
Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis.
Alan D Salama, Tanuja Chitnis, +7 authors, Samia J Khoury.
J Exp Med, 2003 Jul 09; 198(1). PMID: 12847138    Free PMC article.
Highly Cited.
Interaction of B7RP-1 with ICOS negatively regulates antigen presentation by B cells.
Patricia Wahl, Roland Schoop, +2 authors, Rudolf P Wüthrich.
Inflammation, 2003 Oct 07; 27(4). PMID: 14527172
T-helper cell tolerance to ubiquitous nuclear antigens.
B Nakken, K E Davis, +2 authors, A D Farris.
Scand J Immunol, 2003 Nov 25; 58(5). PMID: 14629620    Free PMC article.
Costimulatory signals controlling regulatory T cells.
Joerg Ermann, C Garrison Fathman.
Proc Natl Acad Sci U S A, 2003 Dec 17; 100(26). PMID: 14676329    Free PMC article.
Immunology of B7-H1 and its roles in human diseases.
Hideto Tamura, Kiyoyuki Ogata, Haidong Dong, Lieping Chen.
Int J Hematol, 2003 Dec 23; 78(4). PMID: 14686489
The role of ICOS and other costimulatory molecules in allergy and asthma.
Anthony J Coyle, Jose-Carlos Gutierrez-Ramos.
Springer Semin Immunopathol, 2004 Mar 05; 25(3-4). PMID: 14999428
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.
Mübeccel Akdis, Johan Verhagen, +12 authors, Cezmi A Akdis.
J Exp Med, 2004 Jun 03; 199(11). PMID: 15173208    Free PMC article.
Highly Cited.
The candidate gene approach: have murine models informed the study of human SLE?
D S Cunninghame Graham, T J Vyse.
Clin Exp Immunol, 2004 Jun 16; 137(1). PMID: 15196236    Free PMC article.
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.
Yvette E Latchman, Spencer C Liang, +6 authors, Arlene H Sharpe.
Proc Natl Acad Sci U S A, 2004 Jul 14; 101(29). PMID: 15249675    Free PMC article.
Highly Cited.
Role of an intronic polymorphism in the PDCD1 gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid antibodies.
Dharambir K Sanghera, Susan Manzi, +2 authors, M Ilyas Kamboh.
Hum Genet, 2004 Aug 24; 115(5). PMID: 15322919
Current advances in the human lupus genetics.
Nan Shen, Betty P Tsao.
Curr Rheumatol Rep, 2004 Sep 10; 6(5). PMID: 15355752
Bruton's tyrosine kinase is essential for human B cell tolerance.
Yen-Shing Ng, Hedda Wardemann, +2 authors, Eric Meffre.
J Exp Med, 2004 Oct 07; 200(7). PMID: 15466623    Free PMC article.
A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity.
Maureen A McGargill, Ben G Wen, Craig M Walsh, Stephen M Hedrick.
Immunity, 2004 Dec 14; 21(6). PMID: 15589167    Free PMC article.
Dendritic cell-mediated T cell polarization.
Esther C de Jong, Hermelijn H Smits, Martien L Kapsenberg.
Springer Semin Immunopathol, 2004 Dec 21; 26(3). PMID: 15609003
T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens.
Syamal K Datta, Li Zhang, Luting Xu.
J Mol Med (Berl), 2005 Jan 05; 83(4). PMID: 15630591
The balance of immune responses: costimulation verse coinhibition.
Sumit K Subudhi, Maria-Luisa Alegre, Yang-Xin Fu.
J Mol Med (Berl), 2005 Jan 05; 83(3). PMID: 15630593
Costimulation: critical pathways in the immunologic regulation of asthma.
Abdelouahab Bellou, Patricia W Finn.
Curr Allergy Asthma Rep, 2005 Feb 03; 5(2). PMID: 15683616
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.
Jian Wang, Taku Yoshida, +3 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2005 Aug 10; 102(33). PMID: 16087865    Free PMC article.
Highly Cited.
Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).
Bruce R Blazar, William J Murphy.
Philos Trans R Soc Lond B Biol Sci, 2005 Sep 09; 360(1461). PMID: 16147539    Free PMC article.
Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes.
Mary E Keir, Yvette E Latchman, Gordon J Freeman, Arlene H Sharpe.
J Immunol, 2005 Nov 23; 175(11). PMID: 16301644    Free PMC article.
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.
Taku Okazaki, Yumi Otaka, +4 authors, Tasuku Honjo.
J Exp Med, 2005 Dec 15; 202(12). PMID: 16352741    Free PMC article.
Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells.
Alison Taylor, Johan Verhagen, +2 authors, Cezmi A Akdis.
Immunology, 2006 Mar 25; 117(4). PMID: 16556256    Free PMC article.
Highly Cited. Review.
No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation.
Katharina Pfistershammer, Christoph Klauser, +5 authors, Peter Steinberger.
Eur J Immunol, 2006 Apr 07; 36(5). PMID: 16598819    Free PMC article.
Checkpoint blockade in cancer immunotherapy.
Alan J Korman, Karl S Peggs, James P Allison.
Adv Immunol, 2006 May 30; 90. PMID: 16730267    Free PMC article.
Highly Cited. Review.
Modification of accessory molecule signaling.
Mary K Crow.
Springer Semin Immunopathol, 2006 Jun 02; 27(4). PMID: 16738953
BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation.
Thang Nguyen, Xikui K Liu, Yongliang Zhang, Chen Dong.
J Immunol, 2006 Jun 06; 176(12). PMID: 16751379    Free PMC article.
Regulation of T cell activation and tolerance by PDL2.
Yongliang Zhang, Yeonseok Chung, +8 authors, Chen Dong.
Proc Natl Acad Sci U S A, 2006 Jul 26; 103(31). PMID: 16864790    Free PMC article.
Immunoregulatory role of B7-H1 in chronicity of inflammatory responses.
Haidong Dong, Xianming Chen.
Cell Mol Immunol, 2006 Aug 09; 3(3). PMID: 16893498    Free PMC article.
Generation and characterization of B7-H4/B7S1/B7x-deficient mice.
Woong-Kyung Suh, Seng Wang, +14 authors, Tak W Mak.
Mol Cell Biol, 2006 Aug 18; 26(17). PMID: 16914726    Free PMC article.
The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility.
Marta E Alarcón-Riquelme.
Springer Semin Immunopathol, 2006 Sep 12; 28(2). PMID: 16964481
Genetics of SLE in mice.
Dwight H Kono, Argyrios N Theofilopoulos.
Springer Semin Immunopathol, 2006 Sep 15; 28(2). PMID: 16972052
Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications.
Lequn Li, Vassiliki A Boussiotis.
J Mol Med (Berl), 2006 Sep 15; 84(11). PMID: 16972086
Unraveling the genetics of systemic lupus erythematosus.
John B Harley, Jennifer A Kelly, Kenneth M Kaufman.
Springer Semin Immunopathol, 2006 Oct 06; 28(2). PMID: 17021721
Programmed death-1 gene polymorphisms in patients with systemic lupus erythematosus in Taiwan.
Shu-Chen Wang, Yi-Jing Chen, +4 authors, Jeng-Hsien Yen.
J Clin Immunol, 2006 Oct 07; 26(6). PMID: 17024563
Association of the programmed cell death 1 (PDCD1) gene polymorphism with ankylosing spondylitis in the Korean population.
Sang-Hoon Lee, Yeon-Ah Lee, +8 authors, Hyung-In Yang.
Arthritis Res Ther, 2006 Oct 27; 8(6). PMID: 17064404    Free PMC article.
Activating and inhibitory FcgammaRs in autoimmune disorders.
Falk Nimmerjahn.
Springer Semin Immunopathol, 2006 Nov 23; 28(4). PMID: 17115158
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
Brian T Fife, Indira Guleria, +7 authors, Jeffrey A Bluestone.
J Exp Med, 2006 Nov 23; 203(12). PMID: 17116737    Free PMC article.
Highly Cited.
Immunosuppressive strategies that are mediated by tumor cells.
Gabriel A Rabinovich, Dmitry Gabrilovich, Eduardo M Sotomayor.
Annu Rev Immunol, 2006 Dec 01; 25. PMID: 17134371    Free PMC article.
Highly Cited. Review.
Potent systemic antitumor immunity induced by vaccination with chemotactic-prostate tumor associated antigen gene-modified tumor cell and blockade of B7-H1.
Ning Li, Hanjun Qin, +7 authors, Shuren Zhang.
J Clin Immunol, 2006 Dec 21; 27(1). PMID: 17180470
PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children.
Ronghua Ni, Kenji Ihara, +4 authors, Toshiro Hara.
Hum Genet, 2007 Jan 05; 121(2). PMID: 17203303
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling.
Adrian Liston, Kristine Hardy, +4 authors, Christopher C Goodnow.
Genome Biol, 2007 Jan 24; 8(1). PMID: 17239257    Free PMC article.
DC-HIL is a negative regulator of T lymphocyte activation.
Jin-Sung Chung, Kota Sato, +2 authors, Kiyoshi Ariizumi.
Blood, 2007 Feb 08; 109(10). PMID: 17284525    Free PMC article.
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.
Fumihiko Tsushima, Sheng Yao, +6 authors, Lieping Chen.
Blood, 2007 Feb 10; 110(1). PMID: 17289811    Free PMC article.
Putting T cells to sleep: a new paradigm for immune evasion by persistent viruses.
Shweta Dubey, Shahid Jameel.
J Biosci, 2007 Feb 16; 31(5). PMID: 17301484
Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort.
C M Thorburn, L Prokunina-Olsson, +4 authors, L A Criswell.
Genes Immun, 2007 Mar 09; 8(4). PMID: 17344889    Free PMC article.
Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy.
David Vermijlen, Peter Ellis, +6 authors, Matthias Eberl.
J Immunol, 2007 Mar 21; 178(7). PMID: 17371987    Free PMC article.
Molecular basis for checkpoints in the CD8 T cell response: tolerance versus activation.
Matthew F Mescher, Pujya Agarwal, +3 authors, Julie M Curtsinger.
Semin Immunol, 2007 Mar 27; 19(3). PMID: 17382557    Free PMC article.
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.
Monica V Goldberg, Charles H Maris, +12 authors, Charles G Drake.
Blood, 2007 Mar 30; 110(1). PMID: 17392506    Free PMC article.
Costimulation and pancreatic autoimmunity: the PD-1/PD-L conundrum.
Deepak Yadav, Nora Sarvetnick.
Rev Diabet Stud, 2007 May 12; 3(1). PMID: 17491706    Free PMC article.
Polymorphisms of genes for programmed cell death 1 ligands in patients with rheumatoid arthritis.
Shu-Chen Wang, Chia-Hui Lin, +5 authors, Jeng-Hsien Yen.
J Clin Immunol, 2007 Jun 29; 27(6). PMID: 17597384
Inhibitory costimulation and anti-tumor immunity.
Natalia Martin-Orozco, Chen Dong.
Semin Cancer Biol, 2007 Aug 09; 17(4). PMID: 17683946    Free PMC article.
Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation.
Sue-Jane Lin, Craig D Peacock, Kapil Bahl, Raymond M Welsh.
J Exp Med, 2007 Sep 06; 204(10). PMID: 17785507    Free PMC article.
Modulating co-stimulation.
Vissia Viglietta, Samia J Khoury.
Neurotherapeutics, 2007 Oct 09; 4(4). PMID: 17920548    Free PMC article.
B cells in glomerulonephritis: focus on lupus nephritis.
Menna R Clatworthy, Kenneth G C Smith.
Semin Immunopathol, 2007 Oct 19; 29(4). PMID: 17943287
Autoimmunity stimulated by adoptively transferred dendritic cells is initiated by both alphabeta and gammadelta T cells but does not require MyD88 signaling.
David A Martin, Kang Zhang, +4 authors, Keith B Elkon.
J Immunol, 2007 Oct 20; 179(9). PMID: 17947655    Free PMC article.
CD86 has sustained costimulatory effects on CD8 T cells.
Ian J Thomas, Liliana G Petrich de Marquesini, +6 authors, F Susan Wong.
J Immunol, 2007 Oct 20; 179(9). PMID: 17947667    Free PMC article.
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.
Tsvetelina Pentcheva-Hoang, Lieping Chen, Drew M Pardoll, James P Allison.
Proc Natl Acad Sci U S A, 2007 Oct 31; 104(45). PMID: 17968013    Free PMC article.
Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation.
Thomas Lehner.
Immunology, 2007 Dec 25; 123(1). PMID: 18154618    Free PMC article.
T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines.
Tania H Watts, Edward M Bertram, Jacob Bukczynski, Tao Wen.
Can J Infect Dis, 2007 Dec 27; 14(4). PMID: 18159461    Free PMC article.
Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells.
Kristy L Edgtton, Joshua Y Kausman, +6 authors, A Richard Kitching.
J Am Soc Nephrol, 2008 Jan 11; 19(3). PMID: 18184859    Free PMC article.
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.
Takeshi Azuma, Sheng Yao, +3 authors, Lieping Chen.
Blood, 2008 Jan 29; 111(7). PMID: 18223165    Free PMC article.
Highly Cited.
TLR-mediated induction of negative regulatory ligands on dendritic cells.
Stefan Gröschel, Kisha D Piggott, +4 authors, Cornelia M Weyand.
J Mol Med (Berl), 2008 Feb 07; 86(4). PMID: 18253710    Free PMC article.
The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.
Eszter Lázár-Molnár, Attila Gácser, +3 authors, Joshua D Nosanchuk.
Proc Natl Acad Sci U S A, 2008 Feb 13; 105(7). PMID: 18268348    Free PMC article.
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.
David Yin-Wei Lin, Yoshimasa Tanaka, +7 authors, David N Garboczi.
Proc Natl Acad Sci U S A, 2008 Feb 22; 105(8). PMID: 18287011    Free PMC article.
Highly Cited.
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice.
Taku Yoshida, Fang Jiang, Tasuku Honjo, Taku Okazaki.
Proc Natl Acad Sci U S A, 2008 Feb 27; 105(9). PMID: 18299579    Free PMC article.
Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway.
Chris A Benedict, Andrea Loewendorf, +2 authors, Edith M Janssen.
J Immunol, 2008 Mar 21; 180(7). PMID: 18354207    Free PMC article.
Protective role of programmed death 1 ligand 1 (PD-L1)in nonobese diabetic mice: the paradox in transgenic models.
Chia-Jen Wang, Feng-Cheng Chou, +4 authors, Huey-Kang Sytwu.
Diabetes, 2008 Apr 19; 57(7). PMID: 18420489    Free PMC article.
Presence of suppressor HIV-specific CD8+ T cells is associated with increased PD-1 expression on effector CD8+ T cells.
Mohamed Elrefaei, Chris A R Baker, +2 authors, Huyen Cao.
J Immunol, 2008 May 21; 180(11). PMID: 18490780    Free PMC article.
Expression and function of PDCD1 at the human maternal-fetal interface.
Elizabeth S Taglauer, Ann S Trikhacheva, Joyce G Slusser, Margaret G Petroff.
Biol Reprod, 2008 Jun 14; 79(3). PMID: 18550794    Free PMC article.
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.
Fabienne Haspot, Thomas Fehr, +5 authors, Megan Sykes.
Blood, 2008 Jun 26; 112(5). PMID: 18577709    Free PMC article.
Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells.
Li Wang, Karina Pino-Lagos, +3 authors, Randolph J Noelle.
Proc Natl Acad Sci U S A, 2008 Jul 05; 105(27). PMID: 18599457    Free PMC article.
Highly Cited.
Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Eszter Lázár-Molnár, Qingrong Yan, +3 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2008 Jul 22; 105(30). PMID: 18641123    Free PMC article.
Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1.
N Mozaffarian, A E Wiedeman, A M Stevens.
Rheumatology (Oxford), 2008 Jul 25; 47(9). PMID: 18650228    Free PMC article.
Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator.
Yoshihiro Oya, Norihiko Watanabe, +10 authors, Yasushi Saito.
Arthritis Rheum, 2008 Aug 01; 58(8). PMID: 18668554    Free PMC article.
Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.
Julie A Lucas, Julia Menke, +3 authors, Vicki R Kelley.
J Immunol, 2008 Aug 08; 181(4). PMID: 18684942    Free PMC article.
Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism.
Karuppiah Muthumani, Andrew Y Choo, +10 authors, David B Weiner.
J Virol, 2008 Sep 19; 82(23). PMID: 18799583    Free PMC article.
NFATc1 regulates PD-1 expression upon T cell activation.
Kenneth J Oestreich, Hyesuk Yoon, Rafi Ahmed, Jeremy M Boss.
J Immunol, 2008 Sep 20; 181(7). PMID: 18802087    Free PMC article.
Highly Cited.
PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.
Bettina Schreiner, Samantha L Bailey, +2 authors, Stephen D Miller.
Eur J Immunol, 2008 Oct 01; 38(10). PMID: 18825752    Free PMC article.
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure.
Flurina Meiler, Judith Zumkehr, +3 authors, Mübeccel Akdis.
J Exp Med, 2008 Nov 13; 205(12). PMID: 19001136    Free PMC article.
Highly Cited.
Differentiation-induced post-transcriptional control of B7-H1 in human trophoblast cells.
L M Holets, M Z Carletti, +2 authors, M G Petroff.
Placenta, 2008 Nov 18; 30(1). PMID: 19010538    Free PMC article.
Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease.
Maureen A McGargill, Carmen Choy, Ben G Wen, Stephen M Hedrick.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017948    Free PMC article.
Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.
Keiko Nagahara, Tomohiro Arikawa, +12 authors, Mitsuomi Hirashima.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017954    Free PMC article.
Dexamethasone/1alpha-25-dihydroxyvitamin D3-treated dendritic cells suppress colitis in the SCID T-cell transfer model.
Anders Elm Pedersen, Esben Gjerløff Wedebye Schmidt, +2 authors, Mogens Helweg Claesson.
Immunology, 2008 Nov 21; 127(3). PMID: 19019085    Free PMC article.
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection.
David G Brooks, Sang-Jun Ha, +3 authors, Michael B A Oldstone.
Proc Natl Acad Sci U S A, 2008 Dec 17; 105(51). PMID: 19075244    Free PMC article.
Highly Cited.
PD-1 regulates neural damage in oligodendroglia-induced inflammation.
Antje Kroner, Nicholas Schwab, +5 authors, Rudolf Martini.
PLoS One, 2009 Feb 07; 4(2). PMID: 19197390    Free PMC article.
PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.
Vrajesh V Parekh, Saif Lalani, +6 authors, Luc Van Kaer.
J Immunol, 2009 Feb 24; 182(5). PMID: 19234176    Free PMC article.
Immunomodulation in the treatment of haematological malignancies.
Michela Cesco-Gaspere, Emma Morris, Hans J Stauss.
Clin Exp Med, 2009 Feb 25; 9(2). PMID: 19238515
Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation.
Karen L Wood, Homer L Twigg, Andrea I Doseff.
Front Biosci (Landmark Ed), 2009 Mar 11; 14(10). PMID: 19273309    Free PMC article.
PD-1 on dendritic cells impedes innate immunity against bacterial infection.
Sheng Yao, Shengdian Wang, +9 authors, Lieping Chen.
Blood, 2009 Apr 03; 113(23). PMID: 19339692    Free PMC article.
Maternal PD-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy.
Elizabeth S Taglauer, Thomas M Yankee, Margaret G Petroff.
J Reprod Immunol, 2009 Apr 17; 80(1-2). PMID: 19368976    Free PMC article.
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.
Long Zhang, Thomas F Gajewski, Justin Kline.
Blood, 2009 May 07; 114(8). PMID: 19417208    Free PMC article.
Highly Cited.
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
Mojgan Ahmadzadeh, Laura A Johnson, +4 authors, Steven A Rosenberg.
Blood, 2009 May 09; 114(8). PMID: 19423728    Free PMC article.
Highly Cited.
Yin-Yang of costimulation: crucial controls of immune tolerance and function.
Roza I Nurieva, Xikui Liu, Chen Dong.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426216    Free PMC article.
Costimulatory and coinhibitory receptors in anti-tumor immunity.
Gregory Driessens, Justin Kline, Thomas F Gajewski.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426219    Free PMC article.
Sequence, structure, function, immunity: structural genomics of costimulation.
Kausik Chattopadhyay, Eszter Lazar-Molnar, +7 authors, Steven C Almo.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426233    Free PMC article.
Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants.
Antje Kroner, Nicholas Schwab, +6 authors, Heinz Wiendl.
Am J Pathol, 2009 May 16; 174(6). PMID: 19443704    Free PMC article.
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
K S Peggs, S A Quezada, J P Allison.
Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765    Free PMC article.
Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter.
H Kaku, T L Rothstein.
Genes Immun, 2009 Aug 28; 11(1). PMID: 19710692    Free PMC article.
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Benjamin R Marks, Heba N Nowyhed, +4 authors, Joe Craft.
Nat Immunol, 2009 Sep 08; 10(10). PMID: 19734905    Free PMC article.
Chronically inflamed livers up-regulate expression of inhibitory B7 family members.
Rachel Kassel, Michael W Cruise, +3 authors, Young S Hahn.
Hepatology, 2009 Sep 10; 50(5). PMID: 19739236    Free PMC article.
Variable increased expression of program death-1 and program death-1 ligands on peripheral mononuclear cells is not impaired in patients with systemic lupus erythematosus.
Ming-Fei Liu, Chia-Tse Weng, Meng-Yu Weng.
J Biomed Biotechnol, 2009 Sep 18; 2009. PMID: 19759858    Free PMC article.
The role of costimulatory molecules in allergic disease and asthma.
Vincent Lombardi, Abinav K Singh, Omid Akbari.
Int Arch Allergy Immunol, 2009 Sep 30; 151(3). PMID: 19786798    Free PMC article.
Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection.
Shanmugalakshmi Sadagopal, Shelly L Lorey, +5 authors, David W Haas.
J Virol, 2009 Oct 16; 84(1). PMID: 19828602    Free PMC article.
Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C.
Juan-Ramón Larrubia, Selma Benito-Martínez, +3 authors, Trinidad Parra-Cid.
World J Gastroenterol, 2009 Nov 06; 15(41). PMID: 19891011    Free PMC article.
Mechanisms maintaining peripheral tolerance.
Daniel L Mueller.
Nat Immunol, 2009 Dec 18; 11(1). PMID: 20016506
Highly Cited. Review.
The effects of PDL-Ig on collagen-induced arthritis.
Guohua Wang, Ping Hu, +2 authors, Xiongwen Wu.
Rheumatol Int, 2009 Dec 26; 31(4). PMID: 20035333
Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?
Zili Zhang, James T Rosenbaum, +2 authors, David J Hinrichs.
Semin Immunopathol, 2010 Feb 02; 32(1). PMID: 20119686
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
Michael A Curran, Welby Montalvo, Hideo Yagita, James P Allison.
Proc Natl Acad Sci U S A, 2010 Feb 18; 107(9). PMID: 20160101    Free PMC article.
Highly Cited.
Different in vivo effects of HIV-1 immunodominant epitope-specific cytotoxic T lymphocytes on selection of escape mutant viruses.
Hirokazu Koizumi, Masao Hashimoto, +9 authors, Masafumi Takiguchi.
J Virol, 2010 Mar 26; 84(11). PMID: 20335254    Free PMC article.
Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.
Paula S Ramos, Elisabeth E Brown, Robert P Kimberly, Carl D Langefeld.
Semin Nephrol, 2010 Mar 30; 30(2). PMID: 20347645    Free PMC article.
B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals.
Noweeda Mirza, Maria Adelaida Duque, +3 authors, Joseph Lustgarten.
J Immunol, 2010 Apr 09; 184(10). PMID: 20375308    Free PMC article.
B7 family molecules as regulators of the maternal immune system in pregnancy.
Margaret G Petroff, Antoine Perchellet.
Am J Reprod Immunol, 2010 Apr 14; 63(6). PMID: 20384620    Free PMC article.
PD-1, gender, and autoimmunity.
Ravi K Dinesh, Bevra H Hahn, Ram Pyare Singh.
Autoimmun Rev, 2010 May 04; 9(8). PMID: 20433954    Free PMC article.
PD-1 blockade: A promising immunotherapy for HIV?
Bernard J C Macatangay, Charles R Rinaldo.
Cellscience, 2010 May 22; 5(4). PMID: 20490361    Free PMC article.
The immunotherapeutic potential of dendritic cells in type 1 diabetes.
G Mukherjee, T P Dilorenzo.
Clin Exp Immunol, 2010 May 25; 161(2). PMID: 20491789    Free PMC article.
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Julie R Brahmer, Charles G Drake, +17 authors, Suzanne L Topalian.
J Clin Oncol, 2010 Jun 03; 28(19). PMID: 20516446    Free PMC article.
Highly Cited.
Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.
Eszter Lázár-Molnár, Bing Chen, +7 authors, William R Jacobs.
Proc Natl Acad Sci U S A, 2010 Jul 14; 107(30). PMID: 20624978    Free PMC article.
Highly Cited.
The PD-1 pathway in tolerance and autoimmunity.
Loise M Francisco, Peter T Sage, Arlene H Sharpe.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636820    Free PMC article.
Highly Cited. Review.
Prostate cancer as a model for tumour immunotherapy.
Charles G Drake.
Nat Rev Immunol, 2010 Jul 24; 10(8). PMID: 20651745    Free PMC article.
Highly Cited. Review.
Immune regulatory antibodies: are they the next advance?
Jedd D Wolchok, Arvin S Yang, Jeffrey S Weber.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693841    Free PMC article.
Increased programmed death-1 expression on CD4+ T cells in cutaneous T-cell lymphoma: implications for immune suppression.
Sara Samimi, Bernice Benoit, +4 authors, Alain H Rook.
Arch Dermatol, 2010 Aug 18; 146(12). PMID: 20713771    Free PMC article.
Role of PD-L1 and PD-L2 in allergic diseases and asthma.
A K Singh, P Stock, O Akbari.
Allergy, 2010 Aug 21; 66(2). PMID: 20722638    Free PMC article.
Selection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cells.
Takashi Inozume, Ken-Ichi Hanada, +4 authors, James C Yang.
J Immunother, 2010 Oct 16; 33(9). PMID: 20948441    Free PMC article.
T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics.
Yael S Barach, Jun Sik Lee, Xingxing Zang.
Trends Mol Med, 2010 Oct 26; 17(1). PMID: 20971039    Free PMC article.
B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.
Keith M Hamel, Yanxia Cao, +4 authors, Alison Finnegan.
Eur J Immunol, 2010 Nov 10; 40(11). PMID: 21061440    Free PMC article.
Revisiting immune exhaustion during HIV infection.
Alka Khaitan, Derya Unutmaz.
Curr HIV/AIDS Rep, 2010 Dec 29; 8(1). PMID: 21188556    Free PMC article.
Highly Cited. Review.
L2pB1: a new player in autoimmunity.
Xuemei Zhong, Thomas L Rothstein.
Mol Immunol, 2011 Jan 05; 48(11). PMID: 21195478    Free PMC article.
Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities.
Ahmad Zaheen, Alberto Martin.
Am J Pathol, 2011 Feb 02; 178(2). PMID: 21281778    Free PMC article.
The role of co-inhibitory signals in spontaneous tolerance of weakly mismatched transplants.
Govindarajan Thangavelu, Kenneth M Murphy, +2 authors, Colin C Anderson.
Immunobiology, 2011 Feb 02; 216(8). PMID: 21281982    Free PMC article.
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
B Cell and BAFF dependence of IFN-α-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice.
Noam Jacob, Shunhua Guo, +5 authors, William Stohl.
J Immunol, 2011 Mar 09; 186(8). PMID: 21383240    Free PMC article.
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.
Jaikumar Duraiswamy, Chris C Ibegbu, +11 authors, Rafi Ahmed.
J Immunol, 2011 Mar 09; 186(7). PMID: 21383243    Free PMC article.
Highly Cited.
Timeline: a decade of advances in immunotherapy.
Drew Pardoll.
Nat Med, 2011 Mar 09; 17(3). PMID: 21383743    Free PMC article.
A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis.
Mie Oki, Norihiko Watanabe, +7 authors, Hiroshi Nakajima.
Clin Dev Immunol, 2011 Mar 16; 2011. PMID: 21403914    Free PMC article.
LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.
Carrie L Lucas, Creg J Workman, +4 authors, Megan Sykes.
Blood, 2011 Mar 23; 117(20). PMID: 21422469    Free PMC article.
NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.
Sankar Bhattacharyya, Jolly Deb, +19 authors, Edgar Serfling.
J Exp Med, 2011 Apr 06; 208(4). PMID: 21464221    Free PMC article.
Co-inhibitory molecules: Controlling the effectors or controlling the controllers?
Govindarajan Thangavelu, Christa Smolarchuk, Colin C Anderson.
Self Nonself, 2011 Apr 14; 1(2). PMID: 21487510    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Jeffrey A Bluestone.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898    Free PMC article.
Highly Cited. Review.
Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis.
Bechara Mfarrej, Mary Keir, +4 authors, Indira Guleria.
Clin Immunol, 2011 Apr 19; 140(1). PMID: 21498129    Free PMC article.
Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation.
Shinya Ueki, Antonino Castellaneta, +11 authors, Noriko Murase.
Hepatology, 2011 Apr 20; 54(1). PMID: 21503939    Free PMC article.
Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection.
S Rameeza Allie, Weijun Zhang, Shinchiro Fuse, Edward J Usherwood.
J Immunol, 2011 Apr 29; 186(11). PMID: 21525385    Free PMC article.
Divide and conquer: Blocking graft versus host but not graft versus leukemia T cells with agonist BTLA co-inhibitory signals.
Govindarajan Thangavelu, Colin C Anderson.
Chimerism, 2011 May 07; 2(1). PMID: 21547036    Free PMC article.
Inverse correlation of programmed death 1 (PD-1) expression in T cells to the spinal radiologic changes in Taiwanese patients with ankylosing spondylitis.
Ming-Han Chen, Wei-Sheng Chen, +2 authors, Chung-Tei Chou.
Clin Rheumatol, 2011 May 07; 30(9). PMID: 21547439
WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells.
Denada Dibra, Jeffry Cutrera, Xueqing Xia, Shulin Li.
PLoS One, 2011 May 12; 6(4). PMID: 21559505    Free PMC article.
PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine.
Jacalyn Rosenblatt, Brett Glotzbecker, +10 authors, David Avigan.
J Immunother, 2011 May 18; 34(5). PMID: 21577144    Free PMC article.
Highly Cited.
Costimulatory pathways in transplantation.
Nina Pilat, Mohamed H Sayegh, Thomas Wekerle.
Semin Immunol, 2011 May 28; 23(4). PMID: 21616680    Free PMC article.
cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells.
Petra Verdino, Deborah A Witherden, +3 authors, Ian A Wilson.
PLoS One, 2011 Jun 02; 6(5). PMID: 21629689    Free PMC article.
Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.
Tao Shen, Jiajia Zheng, +5 authors, Fengmin Lu.
Virol J, 2011 Jun 08; 8. PMID: 21645420    Free PMC article.
Prostate cancer immunotherapy.
Kenneth F May, James L Gulley, +2 authors, Philip W Kantoff.
Clin Cancer Res, 2011 Jun 28; 17(16). PMID: 21700764    Free PMC article.
Relatively increased number of liver Foxp(3+) regulatory T cells against hepatic lesions in murine lupus.
Likai Yu, Anbin Huang, +3 authors, Xiaohua Hou.
J Huazhong Univ Sci Technolog Med Sci, 2011 Aug 09; 31(4). PMID: 21823008
The expression and distribution of immunomodulatory proteins B7-H1, B7-DC, B7-H3, and B7-H4 in rheumatoid synovium.
Guoning Guo, Yongjun Shang, +3 authors, Yongwen Chen.
Clin Rheumatol, 2011 Aug 13; 31(2). PMID: 21833687
Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets.
Chuanwu Wang, Peter Hillsamer, Chang H Kim.
BMC Immunol, 2011 Sep 15; 12. PMID: 21914188    Free PMC article.
Role of immunotherapy for renal cell cancer in 2011.
Saby George, Roberto Pili, Michael A Carducci, Jenny J Kim.
J Natl Compr Canc Netw, 2011 Sep 16; 9(9). PMID: 21917625    Free PMC article.
Beyond cancer vaccines: a reason for future optimism with immunomodulatory therapy.
Michael Postow, Margaret K Callahan, Jedd D Wolchok.
Cancer J, 2011 Sep 29; 17(5). PMID: 21952288    Free PMC article.
The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion.
Kimberly A Hofmeyer, Hyungjun Jeon, Xingxing Zang.
J Biomed Biotechnol, 2011 Oct 01; 2011. PMID: 21960736    Free PMC article.
Programmed cell death 1 suppresses B-1b cell expansion and long-lived IgG production in response to T cell-independent type 2 antigens.
Karen M Haas.
J Immunol, 2011 Oct 18; 187(10). PMID: 22003198    Free PMC article.
Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.
Qianli Meng, Haike Guo, +3 authors, Peizeng Yang.
PLoS One, 2011 Nov 01; 6(10). PMID: 22039410    Free PMC article.
Genes, tolerance and systemic autoimmunity.
Ram P Singh, Richard T Waldron, Bevra H Hahn.
Autoimmun Rev, 2011 Dec 14; 11(9). PMID: 22155015    Free PMC article.
Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype.
Xiaobin Tang, Linjie Tian, +5 authors, John E Coligan.
J Immunol, 2011 Dec 14; 188(2). PMID: 22156345    Free PMC article.
Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.
Dallas B Flies, Britt J Sandler, Mario Sznol, Lieping Chen.
Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180678    Free PMC article.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Oana Draghiciu, Hans W Nijman, Toos Daemen.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971    Free PMC article.
Cancer immunotherapy comes of age.
Ira Mellman, George Coukos, Glenn Dranoff.
Nature, 2011 Dec 24; 480(7378). PMID: 22193102    Free PMC article.
Highly Cited. Review.
Role of PD-1 in HIV pathogenesis and as target for therapy.
Filippos Porichis, Daniel E Kaufmann.
Curr HIV/AIDS Rep, 2011 Dec 27; 9(1). PMID: 22198819    Free PMC article.
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Curr Opin Immunol, 2012 Jan 13; 24(2). PMID: 22236695    Free PMC article.
Highly Cited. Review.
Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
Masanori Iseki, Miyuki Omori-Miyake, +4 authors, Steven F Ziegler.
Int Immunol, 2012 Jan 28; 24(3). PMID: 22281511    Free PMC article.
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.
Julius Clemence R Hafalla, Carla Claser, +4 authors, Eleanor M Riley.
PLoS Pathog, 2012 Feb 10; 8(2). PMID: 22319445    Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy.
Drew Pardoll, Charles Drake.
J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682    Free PMC article.
TNF-α and TGF-β counter-regulate PD-L1 expression on monocytes in systemic lupus erythematosus.
Jing-Ni Ou, Alice E Wiedeman, Anne M Stevens.
Sci Rep, 2012 Mar 06; 2. PMID: 22389764    Free PMC article.
Immunity, cancer and aging: lessons from mouse models.
Cheryl E Myers, Noweeda N Mirza, Joseph Lustgarten.
Aging Dis, 2012 Mar 08; 2(6). PMID: 22396898    Free PMC article.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma.
Michael A Postow, James Harding, Jedd D Wolchok.
Cancer J, 2012 Mar 29; 18(2). PMID: 22453017    Free PMC article.
Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism.
Guilin Qiao, Lifen Yang, +4 authors, Jian Zhang.
Clin Immunol, 2012 Mar 31; 143(2). PMID: 22459706    Free PMC article.
Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.
Stefano Caserta, Norman Nausch, +5 authors, Rose Zamoyska.
PLoS One, 2012 Apr 13; 7(4). PMID: 22496920    Free PMC article.
Positive and negative regulation of cellular immune responses in physiologic conditions and diseases.
S Viganò, M Perreau, G Pantaleo, A Harari.
Clin Dev Immunol, 2012 May 02; 2012. PMID: 22548114    Free PMC article.
Immunotherapy of cancer in 2012.
John M Kirkwood, Lisa H Butterfield, +3 authors, Soldano Ferrone.
CA Cancer J Clin, 2012 May 12; 62(5). PMID: 22576456    Free PMC article.
Highly Cited. Review.
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Tadashi Yokosuka, Masako Takamatsu, +3 authors, Takashi Saito.
J Exp Med, 2012 May 30; 209(6). PMID: 22641383    Free PMC article.
Highly Cited.
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Julie R Brahmer, Scott S Tykodi, +23 authors, Jon M Wigginton.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658128    Free PMC article.
Highly Cited.
T-cell tolerance: central and peripheral.
Yan Xing, Kristin A Hogquist.
Cold Spring Harb Perspect Biol, 2012 Jun 05; 4(6). PMID: 22661634    Free PMC article.
Highly Cited.
Immune checkpoints in central nervous system autoimmunity.
Nicole Joller, Anneli Peters, Ana C Anderson, Vijay K Kuchroo.
Immunol Rev, 2012 Jun 26; 248(1). PMID: 22725958    Free PMC article.
Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms.
Sivan Sapoznik, Ohad Hammer, +4 authors, Gal Markel.
Clin Dev Immunol, 2012 Jul 11; 2012. PMID: 22778766    Free PMC article.
Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity.
Christian T Mayer, Luciana Berod, Tim Sparwasser.
Front Immunol, 2012 Jul 12; 3. PMID: 22783257    Free PMC article.
Immunoregulatory molecules are master regulators of inflammation during the immune response.
Hortensia de la Fuente, Danay Cibrián, Francisco Sánchez-Madrid.
FEBS Lett, 2012 Jul 24; 586(18). PMID: 22819828    Free PMC article.
Immunotherapy for prostate cancer enters its golden age.
Sosipatros A Boikos, Emmanuel S Antonarakis.
Clin Med Insights Oncol, 2012 Jul 31; 6. PMID: 22844202    Free PMC article.
Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-on-chronic liver failure.
Dayan Cao, Huan Xu, +5 authors, Yongwen Chen.
Inflammation, 2012 Aug 17; 36(1). PMID: 22895698
Role of the PD-1 pathway in the immune response.
L V Riella, A M Paterson, A H Sharpe, A Chandraker.
Am J Transplant, 2012 Aug 21; 12(10). PMID: 22900886    Free PMC article.
Highly Cited. Review.
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines.
Weiyi Peng, Chengwen Liu, +8 authors, Patrick Hwu.
Cancer Res, 2012 Aug 24; 72(20). PMID: 22915761    Free PMC article.
Highly Cited.
Coinhibitory molecules in autoimmune diseases.
Norihiko Watanabe, Hiroshi Nakajima.
Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525    Free PMC article.
T-cell inhibitors: a bench-to-bedside review.
Shinjita Das, Kiyoshi Ariizumi, Ponciano D Cruz.
Dermatitis, 2012 Sep 27; 23(5). PMID: 23010825    Free PMC article.
Advances in the development of cancer immunotherapies.
Jianjun Gao, Chantale Bernatchez, +2 authors, Patrick Hwu.
Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830    Free PMC article.
The 2q37-deletion syndrome: an update of the clinical spectrum including overweight, brachydactyly and behavioural features in 14 new patients.
Camille Leroy, Emilie Landais, +27 authors, Martine Doco-Fenzy.
Eur J Hum Genet, 2012 Oct 18; 21(6). PMID: 23073310    Free PMC article.
Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity.
Jean-Nicolas Schickel, Jean-Louis Pasquali, +8 authors, Pauline Soulas-Sprauel.
EMBO Mol Med, 2012 Oct 31; 4(12). PMID: 23109291    Free PMC article.
Costimulation blockade: current perspectives and implications for therapy.
Gillian Kinnear, Nick D Jones, Kathryn J Wood.
Transplantation, 2012 Nov 07; 95(4). PMID: 23129000    Free PMC article.
PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production.
I P Lewkowich, S Lajoie, +7 authors, M Wills-Karp.
Mucosal Immunol, 2012 Nov 15; 6(4). PMID: 23149662    Free PMC article.
Immunology beats cancer: a blueprint for successful translation.
Drew M Pardoll.
Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205    Free PMC article.
Immunotherapies: the blockade of inhibitory signals.
Yan-Ling Wu, Jing Liang, +2 authors, Hiroshi Sugiyama.
Int J Biol Sci, 2012 Dec 01; 8(10). PMID: 23197939    Free PMC article.
Immune tolerance and transplantation.
Onder Alpdogan, Marcel R M van den Brink.
Semin Oncol, 2012 Dec 05; 39(6). PMID: 23206840    Free PMC article.
The role of B7 family molecules in hematologic malignancy.
Paul Greaves, John G Gribben.
Blood, 2012 Dec 12; 121(5). PMID: 23223433    Free PMC article.
Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.
Helge Frebel, Veronika Nindl, +8 authors, Annette Oxenius.
J Exp Med, 2012 Dec 12; 209(13). PMID: 23230000    Free PMC article.
Highly Cited.
Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer.
Patricia A Tang, Daniel Y C Heng.
Curr Oncol Rep, 2012 Dec 25; 15(2). PMID: 23263823
Demystifying immunotherapy in prostate cancer: understanding current and future treatment strategies.
Ravi A Madan, James L Gulley, Philip W Kantoff.
Cancer J, 2013 Jan 23; 19(1). PMID: 23337757    Free PMC article.
Adenovirus expressing both thymidine kinase and soluble PD1 enhances antitumor immunity by strengthening CD8 T-cell response.
Seung-Pil Shin, Hye-Hyun Seo, +7 authors, Sang-Jin Lee.
Mol Ther, 2013 Jan 23; 21(3). PMID: 23337984    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
Rationale for targeting the immune system through checkpoint molecule blockade in the treatment of non-small-cell lung cancer.
C Zielinski, S Knapp, C Mascaux, F Hirsch.
Ann Oncol, 2013 Feb 09; 24(5). PMID: 23393121    Free PMC article.
Structure and interactions of the human programmed cell death 1 receptor.
Xiaoxiao Cheng, Vaclav Veverka, +16 authors, Simon J Davis.
J Biol Chem, 2013 Feb 19; 288(17). PMID: 23417675    Free PMC article.
Highly Cited.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.
Mario Sznol, Lieping Chen.
Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460533    Free PMC article.
Highly Cited.
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer.
S A Quezada, K S Peggs.
Br J Cancer, 2013 Mar 21; 108(8). PMID: 23511566    Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
Genomics of vasculitis: lessons from mouse models.
Masato Nose, Hiroaki Komori, Tatsuhiko Miyazaki, Shiro Mori.
Ann Vasc Dis, 2013 May 04; 6(1). PMID: 23641278    Free PMC article.
PD-1 regulates T cell proliferation in a tissue and subset-specific manner during normal mouse pregnancy.
Michelle T Shepard, Elizabeth A Bonney.
Immunol Invest, 2013 Jun 21; 42(5). PMID: 23782245    Free PMC article.
B7 family checkpoint regulators in immune regulation and disease.
Sabrina Ceeraz, Elizabeth C Nowak, Randolph J Noelle.
Trends Immunol, 2013 Aug 21; 34(11). PMID: 23954143    Free PMC article.
Highly Cited. Review.
The role of interleukin-6 in the expression of PD-1 and PDL-1 on central nervous system cells following infection with Theiler's murine encephalomyelitis virus.
Young-Hee Jin, Wanqiu Hou, +2 authors, Byung S Kim.
J Virol, 2013 Aug 24; 87(21). PMID: 23966393    Free PMC article.
Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells.
Paul Greaves, Andrew Clear, +6 authors, John G Gribben.
Blood, 2013 Sep 06; 122(16). PMID: 24004665    Free PMC article.
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response.
Yuxiang Rui, Tasuku Honjo, Shunsuke Chikuma.
Proc Natl Acad Sci U S A, 2013 Sep 18; 110(40). PMID: 24043779    Free PMC article.
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Yan Gao, Simone A Nish, +5 authors, Ruslan Medzhitov.
Immunity, 2013 Oct 01; 39(4). PMID: 24076050    Free PMC article.
Highly Cited.
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis.
Su-Jin Moon, Jin-Sil Park, +11 authors, Mi-La Cho.
Exp Mol Med, 2013 Oct 05; 45. PMID: 24091748    Free PMC article.
Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma.
D Atanackovic, T Luetkens, N Kröger.
Leukemia, 2013 Oct 25; 28(5). PMID: 24153012
PD-1 modulates steady-state and infection-induced IL-10 production in vivo.
Cortez McBerry, Alexandra Dias, +5 authors, Julio Aliberti.
Eur J Immunol, 2013 Oct 30; 44(2). PMID: 24165808    Free PMC article.
Tolerance and exhaustion: defining mechanisms of T cell dysfunction.
Andrea Schietinger, Philip D Greenberg.
Trends Immunol, 2013 Nov 12; 35(2). PMID: 24210163    Free PMC article.
Highly Cited. Review.
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.
Taku Okazaki, Shunsuke Chikuma, +2 authors, Tasuku Honjo.
Nat Immunol, 2013 Nov 19; 14(12). PMID: 24240160
Highly Cited. Review.
PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.
Victor D Fedorov, Maria Themeli, Michel Sadelain.
Sci Transl Med, 2013 Dec 18; 5(215). PMID: 24337479    Free PMC article.
Highly Cited.
Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go.
Angela Vasaturo, Stefania Di Blasio, +4 authors, Stanleyson V Hato.
Front Immunol, 2013 Dec 19; 4. PMID: 24348481    Free PMC article.
Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis.
Xin Huang, Yaping Chen, +4 authors, Alfred Ayala.
J Immunol, 2014 Jan 01; 192(3). PMID: 24379123    Free PMC article.
PD-1 as a potential target in cancer therapy.
David F McDermott, Michael B Atkins.
Cancer Med, 2014 Jan 10; 2(5). PMID: 24403232    Free PMC article.
Highly Cited. Review.
To be, or not to be immunocompetent.
Hans-Dieter Volk, Petra Reinke.
Crit Care, 2014 Feb 07; 17(5). PMID: 24499649    Free PMC article.
The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.
Jin-Sung Chung, Kyoichi Tamura, +2 authors, Kiyoshi Ariizumi.
J Immunol, 2014 Feb 12; 192(6). PMID: 24516197    Free PMC article.
Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer?
Julie R Brahmer.
Semin Oncol, 2014 Feb 26; 41(1). PMID: 24565586    Free PMC article.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander".
Lucia Gelao, Carmen Criscitiello, +2 authors, Giuseppe Curigliano.
Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636    Free PMC article.
Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy.
Maxine Bauzon, Terry Hermiston.
Front Immunol, 2014 Mar 08; 5. PMID: 24605114    Free PMC article.
Immune and genetic gardening of the intestinal microbiome.
Jonathan P Jacobs, Jonathan Braun.
FEBS Lett, 2014 Mar 13; 588(22). PMID: 24613921    Free PMC article.
Fallen angels or risen apes? A tale of the intricate complexities of imbalanced immune responses in the pathogenesis and progression of immune-mediated and viral cancers.
Beatrice Omusiro Ondondo.
Front Immunol, 2014 Mar 19; 5. PMID: 24639678    Free PMC article.
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.
Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641    Free PMC article.
Highly Cited.
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.
Janis M Taube, Alison Klein, +7 authors, Robert A Anders.
Clin Cancer Res, 2014 Apr 10; 20(19). PMID: 24714771    Free PMC article.
Highly Cited.
Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy.
Thomas E Stinchcombe.
Med Oncol, 2014 Apr 22; 31(5). PMID: 24748366    Free PMC article.
Restoring the balance: immunotherapeutic combinations for autoimmune disease.
Dawn E Smilek, Mario R Ehlers, Gerald T Nepom.
Dis Model Mech, 2014 May 06; 7(5). PMID: 24795433    Free PMC article.
A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China.
Cuiping Liu, Juean Jiang, +6 authors, Xueguang Zhang.
Int J Genomics, 2014 May 08; 2014. PMID: 24804191    Free PMC article.
Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.
Ilian A Radichev, Lilia V Maneva-Radicheva, +6 authors, Alexei Y Savinov.
Diabetes, 2014 May 23; 63(10). PMID: 24848066    Free PMC article.
Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene.
Qingqing Jiao, Cuiping Liu, +11 authors, Qihong Qian.
Int J Genomics, 2014 May 27; 2014. PMID: 24860805    Free PMC article.
The development of endometrial hyperplasia in aged PD-1-deficient female mice.
Guoning Guo, Hong Li, Dayan Cao, Yongwen Chen.
Diagn Pathol, 2014 Jun 03; 9. PMID: 24886298    Free PMC article.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.
Yi-Chi M Kong, Jeffrey C Flynn.
Front Immunol, 2014 Jun 07; 5. PMID: 24904570    Free PMC article.
DC-HIL+ CD14+ HLA-DR no/low cells are a potential blood marker and therapeutic target for melanoma.
Jake Turrentine, Jin-Sung Chung, +7 authors, Ponciano D Cruz.
J Invest Dermatol, 2014 Jun 17; 134(11). PMID: 24933321    Free PMC article.
PD-1 regulates extrathymic regulatory T-cell differentiation.
Xiufen Chen, Dominick Fosco, +4 authors, Justin Kline.
Eur J Immunol, 2014 Jul 01; 44(9). PMID: 24975127    Free PMC article.
Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes.
Naoko Okiyama, Stephen I Katz.
J Autoimmun, 2014 Jul 23; 53. PMID: 25047812    Free PMC article.
Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands.
Xijun Ou, Shengli Xu, Yan-Feng Li, Kong-Peng Lam.
Proc Natl Acad Sci U S A, 2014 Jul 24; 111(31). PMID: 25053811    Free PMC article.
From the guest editor: Tumor site immune modulation therapy.
Lieping Chen.
Cancer J, 2014 Aug 08; 20(4). PMID: 25098284    Free PMC article.
PD-1 as an immune modulatory receptor.
Sheng Yao, Lieping Chen.
Cancer J, 2014 Aug 08; 20(4). PMID: 25098286    Free PMC article.
Biochemical signaling of PD-1 on T cells and its functional implications.
Vassiliki A Boussiotis, Pranam Chatterjee, Lequn Li.
Cancer J, 2014 Aug 08; 20(4). PMID: 25098287    Free PMC article.
PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence.
Scott S Tykodi.
Onco Targets Ther, 2014 Aug 13; 7. PMID: 25114573    Free PMC article.
T-bet regulates differentiation of forkhead box protein 3+ regulatory T cells in programmed cell death-1-deficient mice.
M Tahara, Y Kondo, +5 authors, T Sumida.
Clin Exp Immunol, 2014 Sep 16; 179(2). PMID: 25219397    Free PMC article.
Targeting dendritic cell function during systemic autoimmunity to restore tolerance.
Juan P Mackern-Oberti, Fabián Vega, +2 authors, Alexis M Kalergis.
Int J Mol Sci, 2014 Sep 18; 15(9). PMID: 25229821    Free PMC article.
Regulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological Disorders.
Shangfeng Zhao, Fengwu Li, +2 authors, Xiaoming Hu.
Front Cell Neurosci, 2014 Sep 19; 8. PMID: 25232304    Free PMC article.
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Li Wang, Isabelle Le Mercier, +7 authors, Randolph J Noelle.
Proc Natl Acad Sci U S A, 2014 Oct 01; 111(41). PMID: 25267631    Free PMC article.
The programmed death-1 immune-suppressive pathway: barrier to antitumor immunity.
Suzanne Ostrand-Rosenberg, Lucas A Horn, Samuel T Haile.
J Immunol, 2014 Oct 05; 193(8). PMID: 25281753    Free PMC article.
Highly Cited. Review.
T cell-macrophage interactions and granuloma formation in vasculitis.
Marc Hilhorst, Tsuyoshi Shirai, +2 authors, Cornelia M Weyand.
Front Immunol, 2014 Oct 14; 5. PMID: 25309534    Free PMC article.
Neuropilin-1 expression is induced on tolerant self-reactive CD8+ T cells but is dispensable for the tolerant phenotype.
Stephanie R Jackson, Melissa Berrien-Elliott, +2 authors, Ryan M Teague.
PLoS One, 2014 Oct 25; 9(10). PMID: 25343644    Free PMC article.
PD-1 induction through TCR activation is partially regulated by endogenous TGF-β.
Raja Rekik, Nadia Belhadj Hmida, +3 authors, Melika Ben Ahmed.
Cell Mol Immunol, 2014 Nov 05; 12(5). PMID: 25363526    Free PMC article.
Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men.
Mohammad Reza Zamani, Firouzeh Akbari Asbagh, +3 authors, Nima Rezaei.
J Assist Reprod Genet, 2014 Nov 17; 32(1). PMID: 25399062    Free PMC article.
Myeloid-derived suppressor cells impair alveolar macrophages through PD-1 receptor ligation during Pneumocystis pneumonia.
Guang-Sheng Lei, Chen Zhang, Chao-Hung Lee.
Infect Immun, 2014 Nov 19; 83(2). PMID: 25404033    Free PMC article.
To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy.
Jessica E Thaxton, Zihai Li.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483644    Free PMC article.
B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease.
Ruishu Deng, Kaniel Cassady, +6 authors, Defu Zeng.
J Immunol, 2014 Dec 10; 194(2). PMID: 25488990    Free PMC article.
The delicate balance of melanoma immunotherapy.
David E Gyorki, Margaret Callahan, Jedd D Wolchok, Charlotte E Ariyan.
Clin Transl Immunology, 2013 Aug 01; 2(8). PMID: 25505953    Free PMC article.
Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Linh T Nguyen, Pamela S Ohashi.
Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622
Highly Cited. Review.
Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.
Rhoanne C McPherson, Joanne E Konkel, +10 authors, Stephen M Anderton.
Elife, 2014 Dec 30; 3. PMID: 25546306    Free PMC article.
Anti-programmed death receptor 1 immunotherapy in melanoma: rationale, evidence and clinical potential.
Morganna Freeman-Keller, Jeffrey S Weber.
Ther Adv Med Oncol, 2015 Jan 02; 7(1). PMID: 25553080    Free PMC article.
Overexpression of programmed death ligands in naturally occurring postweaning multisystemic wasting syndrome.
Feng Yue, Anchun Cheng, +5 authors, Xuannian Wang.
Viral Immunol, 2015 Jan 17; 28(2). PMID: 25594677    Free PMC article.
Immune Checkpoint Blockade in Cancer Therapy.
Michael A Postow, Margaret K Callahan, Jedd D Wolchok.
J Clin Oncol, 2015 Jan 22; 33(17). PMID: 25605845    Free PMC article.
Highly Cited. Review.
Immune checkpoint receptors in regulating immune reactivity in rheumatic disease.
Sabrina Ceeraz, Elizabeth C Nowak, Christopher M Burns, Randolph J Noelle.
Arthritis Res Ther, 2015 Jan 22; 16(5). PMID: 25606596    Free PMC article.
Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.
Jaclyn W McAlees, Stephane Lajoie, +9 authors, Ian P Lewkowich.
Eur J Immunol, 2015 Jan 30; 45(4). PMID: 25630305    Free PMC article.
Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.
R Fujisawa, F Haseda, +8 authors, T Hanafusa.
Clin Exp Immunol, 2015 Feb 17; 180(3). PMID: 25682896    Free PMC article.
Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis.
Lin Cheng, Xian Tang, +13 authors, Zhiwei Chen.
MAbs, 2015 Feb 19; 7(3). PMID: 25692916    Free PMC article.
IL-15 temporally reorients IL-10 biased B-1a cells toward IL-12 expression.
Amlan Kanti Ghosh, Debolina Sinha, +2 authors, Tapas Biswas.
Cell Mol Immunol, 2015 Mar 10; 13(2). PMID: 25748019    Free PMC article.
The Role of Anti-PD-1/PD-L1 Agents in Melanoma: Progress to Date.
Katy K Tsai, Adil I Daud.
Drugs, 2015 Mar 25; 75(6). PMID: 25802230
NF-κB regulates PD-1 expression in macrophages.
Alexander P R Bally, Peiyuan Lu, +4 authors, Jeremy M Boss.
J Immunol, 2015 Mar 27; 194(9). PMID: 25810391    Free PMC article.
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma.
Kathleen M Mahoney, Gordon J Freeman, David F McDermott.
Clin Ther, 2015 Apr 01; 37(4). PMID: 25823918    Free PMC article.
Highly Cited. Review.
Lectin microarray technology identifies specific lectins related to lymph node metastasis of advanced gastric cancer.
Keishi Yamashita, Atsushi Kuno, +5 authors, Masahiko Watanabe.
Gastric Cancer, 2015 Apr 05; 19(2). PMID: 25840959
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Association between PDCD1 Gene Polymorphisms and Risk of Systemic Lupus Erythematosus in Three Main Ethnic Groups of the Malaysian Population.
Kek Heng Chua, Lay Hoong Lian, +2 authors, Tze Pheng Lau.
Int J Mol Sci, 2015 May 06; 16(5). PMID: 25938972    Free PMC article.
Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.
Franz J Gassner, Nadja Zaborsky, +6 authors, Roland Geisberger.
Br J Haematol, 2015 May 06; 170(4). PMID: 25940792    Free PMC article.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
FGL2 as a Multimodality Regulator of Tumor-Mediated Immune Suppression and Therapeutic Target in Gliomas.
Jun Yan, Ling-Yuan Kong, +5 authors, Shulin Li.
J Natl Cancer Inst, 2015 May 15; 107(8). PMID: 25971300    Free PMC article.
Programmed death-1 controls T cell survival by regulating oxidative metabolism.
Victor Tkachev, Stefanie Goodell, +5 authors, Craig A Byersdorfer.
J Immunol, 2015 May 15; 194(12). PMID: 25972478    Free PMC article.
Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model.
Fabienne McClanahan, John C Riches, +6 authors, John G Gribben.
Blood, 2015 May 17; 126(2). PMID: 25979947    Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy.
Keishi Adachi, Koji Tamada.
Cancer Sci, 2015 May 20; 106(8). PMID: 25981182    Free PMC article.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
Programmed death-1 checkpoint blockade in acute myeloid leukemia.
Alison Sehgal, Theresa L Whiteside, Michael Boyiadzis.
Expert Opin Biol Ther, 2015 Jun 04; 15(8). PMID: 26036819    Free PMC article.
Inhibitory Receptors Beyond T Cell Exhaustion.
Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser.
Front Immunol, 2015 Jul 15; 6. PMID: 26167163    Free PMC article.
Highly Cited. Review.
Engineering CAR-T cells: Design concepts.
Shivani Srivastava, Stanley R Riddell.
Trends Immunol, 2015 Jul 15; 36(8). PMID: 26169254    Free PMC article.
Highly Cited. Review.
Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus.
Juan P Mackern-Oberti, Carolina Llanos, +2 authors, Alexis M Kalergis.
Immunology, 2015 Jul 16; 146(4). PMID: 26173489    Free PMC article.
T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment.
Frauke M Schnorfeil, Felix S Lichtenegger, +5 authors, Marion Subklewe.
J Hematol Oncol, 2015 Jul 30; 8. PMID: 26219463    Free PMC article.
Highly Cited.
Why has active immunotherapy not worked in lung cancer?
A Thomas, G Giaccone.
Ann Oncol, 2015 Aug 02; 26(11). PMID: 26232492    Free PMC article.
Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors.
Francesca De Felice, Claudia Marchetti, +4 authors, Pierluigi Benedetti Panici.
J Immunol Res, 2015 Aug 04; 2015. PMID: 26236750    Free PMC article.
Nivolumab in the treatment of malignant melanoma: review of the literature.
Emi Mashima, Akiha Inoue, +10 authors, Motonobu Nakamura.
Onco Targets Ther, 2015 Aug 15; 8. PMID: 26273207    Free PMC article.
Leila Khoja, Marcus O Butler, +2 authors, Anthony M Joshua.
J Immunother Cancer, 2015 Aug 20; 3. PMID: 26288737    Free PMC article.
Lung cancer: Biology and treatment options.
Hassan Lemjabbar-Alaoui, Omer Ui Hassan, Yi-Wei Yang, Petra Buchanan.
Biochim Biophys Acta, 2015 Aug 25; 1856(2). PMID: 26297204    Free PMC article.
Highly Cited. Review.
LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model.
Ruea-Yea Huang, Cheryl Eppolito, +3 authors, Kunle Odunsi.
Oncotarget, 2015 Sep 01; 6(29). PMID: 26318293    Free PMC article.
Highly Cited.
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.
Lieping Chen, Xue Han.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325035    Free PMC article.
Highly Cited. Review.
Several immune escape patterns in non-Hodgkin's lymphomas.
Camille Laurent, Konstantina Charmpi, +7 authors, Jean-Jacques Fournié.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405585    Free PMC article.
Human Cancer Immunotherapy with PD-1/PD-L1 Blockade.
Peilin Zheng, Zhiguang Zhou.
Biomark Cancer, 2015 Oct 09; 7(Suppl 2). PMID: 26448693    Free PMC article.
Clinical significance of programmed death ligand-1 (PD-L1) in colorectal serrated adenocarcinoma.
Hailong Zhu, Huali Qin, +6 authors, Xianghua Yi.
Int J Clin Exp Pathol, 2015 Oct 16; 8(8). PMID: 26464688    Free PMC article.
Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy.
Mohamed L Salem, Ahmed El-Badawy.
World J Hepatol, 2015 Oct 21; 7(23). PMID: 26483866    Free PMC article.
Immune checkpoints and immunotherapy for colorectal cancer.
Preet Paul Singh, Piyush K Sharma, Gayathri Krishnan, A Craig Lockhart.
Gastroenterol Rep (Oxf), 2015 Oct 30; 3(4). PMID: 26510455    Free PMC article.
Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases.
Patrick N Harter, Simon Bernatz, +17 authors, Michel Mittelbronn.
Oncotarget, 2015 Oct 31; 6(38). PMID: 26517811    Free PMC article.
Novel immunotherapies in lymphoid malignancies.
Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes.
Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683    Free PMC article.
Highly Cited. Review.
Association of programmed death-1 gene polymorphism rs2227981 with tumor: evidence from a meta analysis.
Umarjan Mamat, Muyassar Arkinjan.
Int J Clin Exp Med, 2015 Nov 10; 8(8). PMID: 26550254    Free PMC article.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.
Anna Śledzińska, Laurie Menger, +2 authors, Sergio A Quezada.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451    Free PMC article.
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors.
Karishma R Rajani, Richard G Vile.
Viruses, 2015 Nov 19; 7(11). PMID: 26580645    Free PMC article.
Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways.
Cuiping Liu, Juean Jiang, +7 authors, Xueguang Zhang.
Arthritis Res Ther, 2015 Nov 27; 17. PMID: 26608464    Free PMC article.
Programmed cell death ligand 1 (PD-L1) expression on gastric cancer and its relationship with clinicopathologic factors.
Lin Zhang, Miaozhen Qiu, +6 authors, Dajun Yang.
Int J Clin Exp Pathol, 2015 Dec 01; 8(9). PMID: 26617827    Free PMC article.
Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders.
Samir V Parikh, Ana Malvar, +6 authors, Brad H Rovin.
Lupus Sci Med, 2015 Dec 03; 2(1). PMID: 26629350    Free PMC article.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy.
Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake.
Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632    Free PMC article.
An increased number of PD-1+ and Tim-3+ CD8+ T cells is involved in immune evasion in gastric cancer.
Shuichi Takano, Hiroaki Saito, Masahide Ikeguchi.
Surg Today, 2016 Jan 24; 46(11). PMID: 26801344
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.
Kerstin Sarter, Elisa Leimgruber, +16 authors, Walter Reith.
J Exp Med, 2016 Jan 27; 213(2). PMID: 26809444    Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Basics of PD-1 in self-tolerance, infection, and cancer immunity.
Shunsuke Chikuma.
Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303
Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview.
Angela K B Alme, Beerinder S Karir, Bishoy M Faltas, Charles G Drake.
Urol Oncol, 2016 Mar 01; 34(4). PMID: 26923782    Free PMC article.
PD-1 expression conditions T cell avidity within an antigen-specific repertoire.
Sylvain Simon, Virginie Vignard, +4 authors, N Labarriere.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942093    Free PMC article.
Genetic and Epigenetic Regulation of PD-1 Expression.
Alexander P R Bally, James W Austin, Jeremy M Boss.
J Immunol, 2016 Mar 06; 196(6). PMID: 26945088    Free PMC article.
Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment.
Kenneth Friedman, Alexander S Brodsky, +5 authors, Murray B Resnick.
Mod Pathol, 2016 Mar 12; 29(5). PMID: 26965581
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.
Pushpa Jayaraman, Miye K Jacques, +6 authors, Samuel M Behar.
PLoS Pathog, 2016 Mar 12; 12(3). PMID: 26967901    Free PMC article.
Highly Cited.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin.
Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985    Free PMC article.
Highly Cited. Review.
PD-1, PD-L1 and PD-L2 expression in mouse prostate cancer.
Shijie Yang, Qiuyang Zhang, +2 authors, Zongbing You.
Am J Clin Exp Urol, 2016 Apr 14; 4(1). PMID: 27069956    Free PMC article.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy.
Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll.
Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802    Free PMC article.
Highly Cited. Review.
Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis.
Shu-Yi Yin, Feng-Yin Jian, +6 authors, Ning-Sun Yang.
Nat Commun, 2016 Apr 19; 7. PMID: 27089063    Free PMC article.
Fatal GvHD induced by PD-1 inhibitor pembrolizumab in a patient with Hodgkin's lymphoma.
A K Singh, L F Porrata, +5 authors, S Abhyankar.
Bone Marrow Transplant, 2016 Apr 26; 51(9). PMID: 27111048
Role of the tumor microenvironment in mature B-cell lymphoid malignancies.
Nathan H Fowler, Chan Yoon Cheah, +13 authors, Kieron Dunleavy.
Haematologica, 2016 May 02; 101(5). PMID: 27132279    Free PMC article.
PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity.
Tong Seng Lim, Valerie Chew, +4 authors, Paola Ricciardi-Castagnoli.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141339    Free PMC article.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination.
Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert.
Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885
Highly Cited. Review.
Comprehensive Immunohistochemical Study of Programmed Cell Death Ligand 1 (PD-L1): Analysis in 5536 Cases Revealed Consistent Expression in Trophoblastic Tumors.
Shingo Inaguma, Zengfeng Wang, +4 authors, Markku Miettinen.
Am J Surg Pathol, 2016 May 10; 40(8). PMID: 27158757    Free PMC article.
Enhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy.
Jae Hun Shin, Hyung Bae Park, Kyungho Choi.
Immune Netw, 2016 May 11; 16(2). PMID: 27162530    Free PMC article.
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
Jianxun Wang, Masayuki Mizui, +7 authors, Maria I Kontaridis.
J Clin Invest, 2016 May 18; 126(6). PMID: 27183387    Free PMC article.
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Ana C Anderson, Nicole Joller, Vijay K Kuchroo.
Immunity, 2016 May 19; 44(5). PMID: 27192565    Free PMC article.
Highly Cited. Review.
Co-stimulatory and Co-inhibitory Pathways in Autoimmunity.
Qianxia Zhang, Dario A A Vignali.
Immunity, 2016 May 19; 44(5). PMID: 27192568    Free PMC article.
Highly Cited. Review.
PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study.
Hong-Tao Ren, Yi-Ming Li, +9 authors, Zhi-Jun Dai.
Medicine (Baltimore), 2016 May 27; 95(21). PMID: 27227944    Free PMC article.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy.
Weijie Ma, Barbara M Gilligan, Jianda Yuan, Tianhong Li.
J Hematol Oncol, 2016 May 29; 9(1). PMID: 27234522    Free PMC article.
Highly Cited. Review.
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma.
Naoka Murakami, Thiago J Borges, Michifumi Yamashita, Leonardo V Riella.
Clin Kidney J, 2016 Jun 09; 9(3). PMID: 27274826    Free PMC article.
The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats.
Mei Tian, Yonghong Zhang, +3 authors, Aihua Liao.
Sci Rep, 2016 Jun 10; 6. PMID: 27277012    Free PMC article.
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors.
Frank B Cortazar, Kristen A Marrone, +15 authors, David E Leaf.
Kidney Int, 2016 Jun 11; 90(3). PMID: 27282937    Free PMC article.
Highly Cited.
The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints.
Santosha Vardhana, Anas Younes.
Haematologica, 2016 Jul 02; 101(7). PMID: 27365459    Free PMC article.
Engagement of distinct epitopes on CD43 induces different co-stimulatory pathways in human T cells.
Madhura Modak, Otto Majdic, +7 authors, Johannes Stöckl.
Immunology, 2016 Jul 09; 149(3). PMID: 27392084    Free PMC article.
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.
Baihao Zhang, Shunsuke Chikuma, +2 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2016 Jul 14; 113(30). PMID: 27410049    Free PMC article.
Highly Cited.
PD-1/PD-L1 blockade in renal cell cancer.
Kathryn E Beckermann, Douglas B Johnson, Jeffrey A Sosman.
Expert Rev Clin Immunol, 2016 Jul 19; 13(1). PMID: 27426025    Free PMC article.
Metastatic melanoma and immunotherapy.
Benjamin Herzberg, David E Fisher.
Clin Immunol, 2016 Jul 20; 172. PMID: 27430520    Free PMC article.
PD-L1 expression is associated with advanced non-small cell lung cancer.
Zhiquan Chen, Jiandong Mei, +6 authors, Liu Zhang.
Oncol Lett, 2016 Jul 23; 12(2). PMID: 27446371    Free PMC article.
Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression.
Naeem K Patil, Julia K Bohannon, Edward R Sherwood.
Pharmacol Res, 2016 Jul 30; 111. PMID: 27468649    Free PMC article.
Emerging treatments in management of prostate cancer: biomarker validation and endpoints for immunotherapy clinical trial design.
Susan F Slovin.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27471695    Free PMC article.
PD-1 Antibody Monotherapy for Malignant Melanoma: A Systematic Review and Meta-Analysis.
Zhijuan Lin, Xing Chen, +4 authors, Mingzhe Han.
PLoS One, 2016 Aug 03; 11(8). PMID: 27483468    Free PMC article.
Systematic Review.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Benjamin Herzberg, Meghan J Campo, Justin F Gainor.
Oncologist, 2016 Aug 19; 22(1). PMID: 27534574    Free PMC article.
New targeted treatments for non-small-cell lung cancer - role of nivolumab.
Giulia Zago, Mirte Muller, Michel van den Heuvel, Paul Baas.
Biologics, 2016 Aug 19; 10. PMID: 27536062    Free PMC article.
Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?
Michiel van der Vlist, Jurgen Kuball, Timothy R D Radstake, Linde Meyaard.
Nat Rev Rheumatol, 2016 Aug 20; 12(10). PMID: 27539666
Melanoma immunotherapy dominates the field.
Panagiotis Diamantopoulos, Helen Gogas.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563656    Free PMC article.
T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases.
Eoin F McKinney, Kenneth Gc Smith.
Immunol Cell Biol, 2016 Sep 01; 94(10). PMID: 27577866
Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction.
Djoke Hendriks, Yuan He, +5 authors, Edwin Bremer.
Oncoimmunology, 2016 Sep 14; 5(8). PMID: 27622071    Free PMC article.
Varicella-Zoster Virus Downregulates Programmed Death Ligand 1 and Major Histocompatibility Complex Class I in Human Brain Vascular Adventitial Fibroblasts, Perineurial Cells, and Lung Fibroblasts.
Dallas Jones, Anna Blackmon, +4 authors, Maria A Nagel.
J Virol, 2016 Sep 16; 90(23). PMID: 27630241    Free PMC article.
The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: a meta-analysis.
Tengfei Zhang, Jing Xie, +13 authors, Yi Zhang.
Oncotarget, 2016 Sep 30; 7(45). PMID: 27683031    Free PMC article.
On the origin of myeloid-derived suppressor cells.
Camilla Rydberg Millrud, Caroline Bergenfelz, Karin Leandersson.
Oncotarget, 2016 Oct 01; 8(2). PMID: 27690299    Free PMC article.
High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1.
Shoichiro Horita, Yayoi Nomura, +3 authors, Norimichi Nomura.
Sci Rep, 2016 Oct 14; 6. PMID: 27734966    Free PMC article.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.
Vassiliki A Boussiotis.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234    Free PMC article.
Highly Cited. Review.
Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.
Shingo Inaguma, Jerzy Lasota, +3 authors, Markku Miettinen.
Mod Pathol, 2016 Nov 05; 30(2). PMID: 27813511    Free PMC article.
Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies.
Shuguang Tan, Danqing Chen, +9 authors, George F Gao.
Protein Cell, 2016 Nov 07; 7(12). PMID: 27815822    Free PMC article.
Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity.
Tony T Jiang, Tijana Martinov, +4 authors, Sing Sing Way.
Cell Rep, 2016 Nov 10; 17(7). PMID: 27829150    Free PMC article.
Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy.
Maarten Swart, Inge Verbrugge, Joost B Beltman.
Front Oncol, 2016 Nov 17; 6. PMID: 27847783    Free PMC article.
Highly Cited. Review.
Using Model-Based "Learn and Confirm" to Reveal the Pharmacokinetics-Pharmacodynamics Relationship of Pembrolizumab in the KEYNOTE-001 Trial.
J Elassaiss-Schaap, S Rossenu, +4 authors, D P de Alwis.
CPT Pharmacometrics Syst Pharmacol, 2016 Nov 20; 6(1). PMID: 27863143    Free PMC article.
IL-1β, But Not Programed Death-1 and Programed Death Ligand Pathway, Is Critical for the Human Th17 Response to Mycobacterium tuberculosis.
Emmanuel Stephen-Victor, Varun Kumar Sharma, +6 authors, Jagadeesh Bayry.
Front Immunol, 2016 Nov 22; 7. PMID: 27867382    Free PMC article.
The role of B7 family costimulatory molecules and indoleamine 2,3-dioxygenase in primary Sjögren's syndrome and systemic sclerosis.
Nóra Legány, László Berta, +2 authors, Gergely Toldi.
Immunol Res, 2016 Nov 24; 65(3). PMID: 27878564
Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory.
Alexander P R Bally, Yan Tang, +4 authors, Jeremy M Boss.
J Immunol, 2016 Nov 30; 198(1). PMID: 27895178    Free PMC article.
Checkpoint inhibition in myeloma.
Don M Benson.
Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913525    Free PMC article.
Endogenous programmed death ligand-1 restrains the development and onset of Sjӧgren's syndrome in non-obese diabetic mice.
Jing Zhou, Jun-O Jin, Toshihisa Kawai, Qing Yu.
Sci Rep, 2016 Dec 15; 6. PMID: 27966604    Free PMC article.
Immunoregulation in Fungal Diseases.
Jonathan A Roussey, Michal A Olszewski, John J Osterholzer.
Microorganisms, 2016 Dec 16; 4(4). PMID: 27973396    Free PMC article.
PD-1 and its ligands are important immune checkpoints in cancer.
Yinan Dong, Qian Sun, Xinwei Zhang.
Oncotarget, 2016 Dec 16; 8(2). PMID: 27974689    Free PMC article.
Highly Cited. Review.
Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer.
J C Osorio, A Ni, +11 authors, M D Hellmann.
Ann Oncol, 2016 Dec 22; 28(3). PMID: 27998967    Free PMC article.
Highly Cited.
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation.
Kankana Bardhan, Theodora Anagnostou, Vassiliki A Boussiotis.
Front Immunol, 2016 Dec 27; 7. PMID: 28018338    Free PMC article.
Highly Cited. Review.
Genetically engineered mouse models in oncology research and cancer medicine.
Kelly Kersten, Karin E de Visser, Martine H van Miltenburg, Jos Jonkers.
EMBO Mol Med, 2016 Dec 29; 9(2). PMID: 28028012    Free PMC article.
Highly Cited. Review.
Death receptor 6 contributes to autoimmunity in lupus-prone mice.
Daisuke Fujikura, Masahiro Ikesue, +3 authors, Toshimitsu Uede.
Nat Commun, 2017 Jan 04; 8. PMID: 28045014    Free PMC article.
Soluble B and T Lymphocyte Attenuator Correlates to Disease Severity in Sepsis and High Levels Are Associated with an Increased Risk of Mortality.
Anna Lange, Jonas Sundén-Cullberg, Anders Magnuson, Olof Hultgren.
PLoS One, 2017 Jan 06; 12(1). PMID: 28056053    Free PMC article.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger.
Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373    Free PMC article.
Highly Cited. Review.
New Immunotherapy Strategies in Breast Cancer.
Lin-Yu Yu, Jie Tang, +4 authors, Xiao-Ping Chen.
Int J Environ Res Public Health, 2017 Jan 14; 14(1). PMID: 28085094    Free PMC article.
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Kenji Chamoto, Partha S Chowdhury, +4 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2017 Jan 18; 114(5). PMID: 28096382    Free PMC article.
Highly Cited.
Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation.
Richard Greil, Evelyn Hutterer, Tanja Nicole Hartmann, Lisa Pleyer.
Cell Commun Signal, 2017 Jan 20; 15(1). PMID: 28100240    Free PMC article.
Cancer immunotherapy - immune checkpoint blockade and associated endocrinopathies.
David J Byun, Jedd D Wolchok, Lynne M Rosenberg, Monica Girotra.
Nat Rev Endocrinol, 2017 Jan 21; 13(4). PMID: 28106152    Free PMC article.
Highly Cited. Review.
Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.
Hui Zhang, Ryu Watanabe, +5 authors, Cornelia M Weyand.
Proc Natl Acad Sci U S A, 2017 Jan 25; 114(6). PMID: 28115719    Free PMC article.
Highly Cited.
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective.
Jun Wang, Ruirong Yuan, +3 authors, Zihai Li.
J Hematol Oncol, 2017 Jan 27; 10(1). PMID: 28122590    Free PMC article.
Highly Cited. Review.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka.
Blood, 2017 Feb 06; 129(15). PMID: 28151427    Free PMC article.
Highly Cited.
Renal complications of immune checkpoint blockade.
Naoka Murakami, Shveta Motwani, Leonardo V Riella.
Curr Probl Cancer, 2017 Feb 13; 41(2). PMID: 28189263    Free PMC article.
CD103+ lung dendritic cells (LDCs) induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11bhi LDCs.
Sudhanshu Shekhar, Ying Peng, Shuhe Wang, Xi Yang.
Cell Mol Immunol, 2017 Feb 15; 15(4). PMID: 28194020    Free PMC article.
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer.
Andreas D Hartkopf, Florin-Andrei Taran, +4 authors, Sara Y Brucker.
Breast Care (Basel), 2017 Feb 24; 11(6). PMID: 28228704    Free PMC article.
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.
Eszter Lázár-Molnár, Lisa Scandiuzzi, +7 authors, Steven C Almo.
EBioMedicine, 2017 Feb 25; 17. PMID: 28233730    Free PMC article.
Inflammatory cytokines compromise programmed cell death-1 (PD-1)-mediated T cell suppression in inflammatory arthritis through up-regulation of soluble PD-1.
D Bommarito, C Hall, L S Taams, V M Corrigall.
Clin Exp Immunol, 2017 Mar 01; 188(3). PMID: 28245522    Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors.
Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim.
Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545    Free PMC article.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.
Liliana E Lucca, David A Hafler.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696    Free PMC article.
Tim-3 and its role in regulating anti-tumor immunity.
Madhumita Das, Chen Zhu, Vijay K Kuchroo.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258697    Free PMC article.
Highly Cited. Review.
In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network.
Kaitao Li, Xiaoxiao Cheng, +2 authors, Cheng Zhu.
J Biol Chem, 2017 Mar 09; 292(16). PMID: 28270509    Free PMC article.
Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients.
Hui Shi, Junna Ye, +13 authors, Chengde Yang.
Arthritis Res Ther, 2017 Mar 10; 19(1). PMID: 28274252    Free PMC article.
Expanding the B Cell-Centric View of Systemic Lupus Erythematosus.
Peter A Morawski, Silvia Bolland.
Trends Immunol, 2017 Mar 10; 38(5). PMID: 28274696    Free PMC article.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma.
Manohan Sinnadurai, Kerrie L McDonald.
J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764
Immune checkpoint dysfunction in large and medium vessel vasculitis.
Ryu Watanabe, Hui Zhang, +2 authors, Cornelia M Weyand.
Am J Physiol Heart Circ Physiol, 2017 Mar 21; 312(5). PMID: 28314758    Free PMC article.
Imaging and clinicopathological features of nivolumab-related cholangitis in patients with non-small cell lung cancer.
Hisato Kawakami, Junko Tanizaki, +11 authors, Kazuhiko Nakagawa.
Invest New Drugs, 2017 Mar 21; 35(4). PMID: 28317087
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
Jennifer D Moy, Jessica M Moskovitz, Robert L Ferris.
Eur J Cancer, 2017 Mar 23; 76. PMID: 28324750    Free PMC article.
Clinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients.
Takashi Nomizo, Hiroaki Ozasa, +8 authors, Young Hak Kim.
Sci Rep, 2017 Mar 24; 7. PMID: 28332580    Free PMC article.
Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone.
Megan L Cramer, Guohong Shao, +2 authors, Paul T Martin.
Hum Gene Ther, 2017 Mar 28; 28(6). PMID: 28345428    Free PMC article.
Cancer Immunotherapy: Whence and Whither.
Peter J Stambrook, John Maher, Farzin Farzaneh.
Mol Cancer Res, 2017 Mar 31; 15(6). PMID: 28356330    Free PMC article.
Role of TIM-3 in ovarian cancer.
Y Xu, H Zhang, +2 authors, F Zheng.
Clin Transl Oncol, 2017 Mar 31; 19(9). PMID: 28357631
CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway.
Pablo Penaloza-MacMaster.
Immunology, 2017 Apr 05; 151(2). PMID: 28375543    Free PMC article.
Cancer immunotherapies targeting the PD-1 signaling pathway.
Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo.
J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884    Free PMC article.
Highly Cited. Review.
Targeted Therapy in Head and Neck Cancer: An Update on Current Clinical Developments in Epidermal Growth Factor Receptor-Targeted Therapy and Immunotherapies.
Jonathan Moreira, Alexander Tobias, Michael P O'Brien, Mark Agulnik.
Drugs, 2017 Apr 07; 77(8). PMID: 28382569
Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis.
Qiang Liu, Chun-Sheng Li.
Chin Med J (Engl), 2017 Apr 12; 130(8). PMID: 28397730    Free PMC article.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.
Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri.
Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974    Free PMC article.
Meta-analysis of programmed cell death 1 polymorphisms with systemic lupus erythematosus risk.
Jie Gao, Nan Gai, +9 authors, Rong-Guo Fu.
Oncotarget, 2017 Apr 19; 8(22). PMID: 28415570    Free PMC article.
Spotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy.
Vyshak Alva Venur, Monika Joshi, Kenneth G Nepple, Yousef Zakharia.
Drug Des Devel Ther, 2017 Apr 27; 11. PMID: 28442891    Free PMC article.
In vitro and in vivo antivirus activity of an anti-programmed death-ligand 1 (PD-L1) rat-bovine chimeric antibody against bovine leukemia virus infection.
Asami Nishimori, Satoru Konnai, +10 authors, Kazuhiko Ohashi.
PLoS One, 2017 Apr 27; 12(4). PMID: 28445479    Free PMC article.
Checkpoint inhibitors in hematological malignancies.
Chi Young Ok, Ken H Young.
J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851    Free PMC article.
Highly Cited. Review.
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
Sydney R Gordon, Roy L Maute, +10 authors, Irving L Weissman.
Nature, 2017 May 18; 545(7655). PMID: 28514441    Free PMC article.
Highly Cited.
Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer.
Allison M Campbell, Roy H Decker.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529904    Free PMC article.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
Hwei-Fang Tsai, Ping-Ning Hsu.
J Biomed Sci, 2017 May 27; 24(1). PMID: 28545567    Free PMC article.
Targeting the programmed cell death-1 pathway in rheumatoid arthritis.
Sabina Sandigursky, Gregg J Silverman, Adam Mor.
Autoimmun Rev, 2017 Jun 03; 16(8). PMID: 28572054    Free PMC article.
Pembrolizumab-Induced Thyroiditis: Comprehensive Clinical Review and Insights Into Underlying Involved Mechanisms.
Danae A Delivanis, Michael P Gustafson, +5 authors, Mabel Ryder.
J Clin Endocrinol Metab, 2017 Jun 15; 102(8). PMID: 28609832    Free PMC article.
Highly Cited.
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Sebastian Peer, Gottfried Baier, Thomas Gruber.
Oncotarget, 2017 Jun 15; 8(26). PMID: 28611299    Free PMC article.
Autoimmune Diabetes and Thyroiditis Complicating Treatment with Nivolumab.
Li Li, Awais Masood, +2 authors, Alan B Grosbach.
Case Rep Oncol, 2017 Jun 15; 10(1). PMID: 28611636    Free PMC article.
B lymphocytes and cancer: a love-hate relationship.
Grace J Yuen, Ezana Demissie, Shiv Pillai.
Trends Cancer, 2017 Jun 20; 2(12). PMID: 28626801    Free PMC article.
Highly Cited. Review.
Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.
Maher G Nawaf, Maria H Ulvmar, +7 authors, Peter J L Lane.
J Immunol, 2017 Jun 25; 199(3). PMID: 28646041    Free PMC article.
PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF.
Conor J Kearney, Najoua Lalaoui, +3 authors, Jane Oliaro.
Cell Death Differ, 2017 Jul 01; 24(10). PMID: 28665401    Free PMC article.
The emerging role of immune checkpoint based approaches in AML and MDS.
Prajwal Boddu, Hagop Kantarjian, +3 authors, Naval Daver.
Leuk Lymphoma, 2017 Jul 07; 59(4). PMID: 28679300    Free PMC article.
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Andrew Gibson, Lee Faulkner, +8 authors, Dean J Naisbitt.
J Immunol, 2017 Jul 09; 199(4). PMID: 28687658    Free PMC article.
B7-H3 role in the immune landscape of cancer.
Jose R Castellanos, Ian J Purvis, +4 authors, Swapna Asuthkar.
Am J Clin Exp Immunol, 2017 Jul 12; 6(4). PMID: 28695059    Free PMC article.
Atezolizumab for the treatment of non-small cell lung cancer.
Fernando C Santini, Charles M Rudin.
Expert Rev Clin Pharmacol, 2017 Jul 18; 10(9). PMID: 28714780    Free PMC article.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.
Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour.
ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757    Free PMC article.
Highly Cited. Review.
Mismatch Repair Deficiency as a Predictive Biomarker for Immunotherapy Efficacy.
Giulia Viale, Dario Trapani, Giuseppe Curigliano.
Biomed Res Int, 2017 Aug 05; 2017. PMID: 28770222    Free PMC article.
The PD-1/PD-L1 Inhibitory Pathway is Altered in Primary Glomerulonephritides.
Ewelina Grywalska, Iwona Smarz-Widelska, +7 authors, Wojciech Zaluska.
Arch Immunol Ther Exp (Warsz), 2017 Aug 05; 66(2). PMID: 28770269    Free PMC article.
Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma.
Shingo Inaguma, Jerzy Lasota, +11 authors, Markku Miettinen.
Hum Pathol, 2017 Aug 16; 71. PMID: 28811252    Free PMC article.
Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies.
Lorenzo Falchi.
Curr Hematol Malig Rep, 2017 Aug 20; 12(5). PMID: 28822058
A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma.
Naoya Maekawa, Satoru Konnai, +13 authors, Kazuhiko Ohashi.
Sci Rep, 2017 Aug 23; 7(1). PMID: 28827658    Free PMC article.
The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases.
Lee Ann Garrett-Sinha, Alyssa Kearly, Anne B Satterthwaite.
Crit Rev Immunol, 2016 Jan 01; 36(6). PMID: 28845756    Free PMC article.
The promise of immunotherapy in head and neck squamous cell carcinoma: combinatorial immunotherapy approaches.
Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri.
ESMO Open, 2017 Aug 30; 1(6). PMID: 28848660    Free PMC article.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656    Free PMC article.
Tim-3, Lag-3, and TIGIT.
Nicole Joller, Vijay K Kuchroo.
Curr Top Microbiol Immunol, 2017 Sep 14; 410. PMID: 28900677    Free PMC article.
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Romualdo Barroso-Sousa, William T Barry, +4 authors, Sara M Tolaney.
JAMA Oncol, 2017 Oct 04; 4(2). PMID: 28973656    Free PMC article.
Highly Cited. Systematic Review.
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
Control of NK Cell Activation by Immune Checkpoint Molecules.
Asma Beldi-Ferchiou, Sophie Caillat-Zucman.
Int J Mol Sci, 2017 Oct 13; 18(10). PMID: 29023417    Free PMC article.
Challenging the standard of care in advanced melanoma: focus on pembrolizumab.
Raghad M Abdul-Karim, C Lance Cowey.
Cancer Manag Res, 2017 Oct 14; 9. PMID: 29026335    Free PMC article.
Safety and efficacy profile of pembrolizumab in solid cancer: pooled reanalysis based on randomized controlled trials.
Manni Wang, Xuelei Ma, Linghong Guo, Fan Xia.
Drug Des Devel Ther, 2017 Oct 17; 11. PMID: 29033546    Free PMC article.
MAGT1-mediated disturbance of Mg2+ homeostasis lead to exhausted of HBV-infected NK and CD8+ T cells.
Bo Diao, Xiaoyong Huang, +4 authors, Yuzhang Wu.
Sci Rep, 2017 Oct 21; 7(1). PMID: 29051561    Free PMC article.
Clinical features, predictive correlates, and pathophysiology of immune-related adverse events in immune checkpoint inhibitor treatments in cancer: a short review.
Jennifer M Yoest.
Immunotargets Ther, 2017 Oct 27; 6. PMID: 29067284    Free PMC article.
PD-1 Controls Tonic Signaling and Lymphopenia-Induced Proliferation of T Lymphocytes.
Kristofor K Ellestad, Jiaxin Lin, Louis Boon, Colin C Anderson.
Front Immunol, 2017 Oct 28; 8. PMID: 29075267    Free PMC article.
Immune checkpoint inhibitors in renal cell carcinoma.
Kirsty Ross, Rob J Jones.
Clin Sci (Lond), 2017 Oct 29; 131(21). PMID: 29079639    Free PMC article.
Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.
Shingo Inaguma, Jerzy Lasota, +6 authors, Markku Miettinen.
J Pathol Clin Res, 2017 Nov 01; 3(4). PMID: 29085667    Free PMC article.
Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy.
Seung Tae Kim, Samuel J Klempner, +6 authors, Jeeyun Lee.
Oncotarget, 2017 Nov 05; 8(44). PMID: 29100397    Free PMC article.
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.
Jiehui Deng, Eric S Wang, +44 authors, Kwok-Kin Wong.
Cancer Discov, 2017 Nov 05; 8(2). PMID: 29101163    Free PMC article.
Highly Cited.
Cardiotoxicity of immune checkpoint inhibitors.
Gilda Varricchi, Maria Rosaria Galdiero, +5 authors, Carlo Gabriele Tocchetti.
ESMO Open, 2017 Nov 07; 2(4). PMID: 29104763    Free PMC article.
Highly Cited. Review.
Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma.
Dirk Schadendorf, Paul Nghiem, +5 authors, Howard L Kaufman.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123950    Free PMC article.
Targeting Immune Cell Checkpoints during Sepsis.
Naeem K Patil, Yin Guo, Liming Luan, Edward R Sherwood.
Int J Mol Sci, 2017 Nov 15; 18(11). PMID: 29135922    Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
PD-L1 expression heterogeneity in non-small cell lung cancer: evaluation of small biopsies reliability.
Enrico Munari, Giuseppe Zamboni, +15 authors, Giuseppe Bogina.
Oncotarget, 2017 Nov 23; 8(52). PMID: 29163815    Free PMC article.
High-affinity human PD-L1 variants attenuate the suppression of T cell activation.
Zhaoduan Liang, Ye Tian, +5 authors, Yi Li.
Oncotarget, 2017 Nov 29; 8(51). PMID: 29179441    Free PMC article.
Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200.
Reginald M Gorczynski, Fang Zhu.
Cancer Manag Res, 2017 Nov 29; 9. PMID: 29180896    Free PMC article.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy.
Robert J Torphy, Richard D Schulick, Yuwen Zhu.
Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042    Free PMC article.
Investigational PD-1 inhibitors in HL and NHL and biomarkers for predictors of response and outcome.
Andres Chang, Danielle Schlafer, Christopher R Flowers, Pamela B Allen.
Expert Opin Investig Drugs, 2017 Dec 13; 27(1). PMID: 29228840    Free PMC article.
Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract.
Michael Dougan.
Front Immunol, 2017 Dec 13; 8. PMID: 29230210    Free PMC article.
Highly Cited. Review.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young.
Front Immunol, 2017 Dec 20; 8. PMID: 29255458    Free PMC article.
Highly Cited. Review.
Forced expression of IL-7R promotes CD8 T cell cytotoxicity to self antigen.
YuFeng Peng.
PLoS One, 2017 Dec 23; 12(12). PMID: 29272267    Free PMC article.
Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma.
Hassan Sadozai, Thomas Gruber, Robert Emil Hunger, Mirjam Schenk.
Front Immunol, 2017 Dec 26; 8. PMID: 29276510    Free PMC article.
IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma.
Seiji Kishi, Masanori Minato, +8 authors, Toshio Doi.
Intern Med, 2017 Dec 28; 57(9). PMID: 29279511    Free PMC article.
Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.
Michael Peled, Anna S Tocheva, +10 authors, Adam Mor.
Proc Natl Acad Sci U S A, 2017 Dec 29; 115(3). PMID: 29282323    Free PMC article.
PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?
Sylvain Simon, Nathalie Labarriere.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296515    Free PMC article.
Highly Cited. Review.
Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma.
Reid W Merryman, Philippe Armand, Kyle T Wright, Scott J Rodig.
Blood Adv, 2018 Jan 04; 1(26). PMID: 29296917    Free PMC article.
Highly Cited. Review.
Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade.
Jie Bai, Zhitao Gao, +3 authors, Jing Nie.
Oncotarget, 2018 Jan 05; 8(66). PMID: 29299180    Free PMC article.
Mycoplasma bovis-Induced Inhibition of Bovine Peripheral Blood Mononuclear Cell Proliferation Is Ameliorated after Blocking the Immune-Inhibitory Programmed Death 1 Receptor.
Muhammad Suleman, Farhan S Cyprian, +4 authors, Jose Perez-Casal.
Infect Immun, 2018 Jan 10; 86(3). PMID: 29311234    Free PMC article.
Inhibitors of the PD-1 Pathway in Tumor Therapy.
Martin W LaFleur, Yuki Muroyama, Charles G Drake, Arlene H Sharpe.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311378    Free PMC article.
Percentages of PD-1+CD4+T cells and PD-L1+DCs are increased and sPD-1 level is elevated in patients with immune thrombocytopenia.
Yingying Wang, Nannan Pang, +9 authors, Jianbing Ding.
Hum Vaccin Immunother, 2018 Jan 16; 14(4). PMID: 29333980    Free PMC article.
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations.
Jun Gong, Alexander Chehrazi-Raffle, Srikanth Reddi, Ravi Salgia.
J Immunother Cancer, 2018 Jan 24; 6(1). PMID: 29357948    Free PMC article.
Highly Cited. Review.
Clinical Development of PD-1 in Advanced Melanoma.
Rodrigo Ramella Munhoz, Michael Andrew Postow.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360722    Free PMC article.
Inhibition of the checkpoint protein PD-1 by the therapeutic antibody pembrolizumab outlined by quantum chemistry.
Ana Beatriz M L A Tavares, José X Lima Neto, Umberto L Fulco, Eudenilson L Albuquerque.
Sci Rep, 2018 Feb 01; 8(1). PMID: 29382901    Free PMC article.
Prior to Peripheral Tolerance, Newly Generated CD4 T Cells Maintain Dangerous Autoimmune Potential: Fas- and Perforin-Independent Autoimmunity Controlled by Programmed Death-1.
Kristofor K Ellestad, Govindarajan Thangavelu, +3 authors, Colin C Anderson.
Front Immunol, 2018 Feb 09; 9. PMID: 29416537    Free PMC article.
Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies.
Danuta J Herzyk, Helen G Haggerty.
AAPS J, 2018 Feb 09; 20(2). PMID: 29417397
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Immune checkpoint inhibitors, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors).
G Redelman-Sidi, O Michielin, +4 authors, O Manuel.
Clin Microbiol Infect, 2018 Feb 11; 24 Suppl 2. PMID: 29427804    Free PMC article.
PD-1 is required to maintain stem cell properties in human dental pulp stem cells.
Yao Liu, Huan Jing, +5 authors, Songtao Shi.
Cell Death Differ, 2018 Feb 24; 25(7). PMID: 29472716    Free PMC article.
Prostaglandin E2 Induction Suppresses the Th1 Immune Responses in Cattle with Johne's Disease.
Yamato Sajiki, Satoru Konnai, +14 authors, Kazuhiko Ohashi.
Infect Immun, 2018 Feb 28; 86(5). PMID: 29483289    Free PMC article.
Immune checkpoint inhibitor (nivolumab)-associated kidney injury and the importance of recognizing concomitant medications known to cause acute tubulointerstitial nephritis: a case report.
Ryo Koda, Hirofumi Watanabe, +5 authors, Ichiei Narita.
BMC Nephrol, 2018 Mar 01; 19(1). PMID: 29486725    Free PMC article.
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.
Yanxia Guo, Alice M Walsh, +18 authors, Sunil Nagpal.
PLoS One, 2018 Mar 01; 13(2). PMID: 29489833    Free PMC article.
Highly Cited.
BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironment.
Guillaume P Andrieu, Jordan S Shafran, +3 authors, Gerald V Denis.
J Leukoc Biol, 2018 Mar 02; 104(2). PMID: 29493812    Free PMC article.
Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes.
Kim L Good-Jacobson, Joanna R Groom.
Front Immunol, 2018 Mar 24; 9. PMID: 29568300    Free PMC article.
Analysis of PD-1 and Tim-3 expression on CD4+ T cells of patients with rheumatoid arthritis; negative association with DAS28.
Zohreh Koohini, Hadi Hossein-Nataj, +3 authors, Hossein Asgarian-Omran.
Clin Rheumatol, 2018 Apr 08; 37(8). PMID: 29626269
Evaluation of programmed cell death protein 1 (PD-1) expression as a prognostic biomarker in patients with clear cell renal cell carcinoma.
Kyu Seo Kim, Rishi R Sekar, +5 authors, Viraj A Master.
Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632730    Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations.
Judith A Seidel, Atsushi Otsuka, Kenji Kabashima.
Front Oncol, 2018 Apr 13; 8. PMID: 29644214    Free PMC article.
Highly Cited. Review.
Immunotherapy for Breast Cancer: Current and Future Strategies.
Austin D Williams, Kyle K Payne, +4 authors, Julia Tchou.
Curr Surg Rep, 2018 Apr 17; 5. PMID: 29657904    Free PMC article.
The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?
Laura de Ramon, Jordi Guiteras, +3 authors, Juan Torras.
Int J Mol Sci, 2018 Apr 26; 19(5). PMID: 29693595    Free PMC article.
Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients.
Sander Bins, Edwin A Basak, +9 authors, Ron H J Mathijssen.
Br J Cancer, 2018 Apr 27; 118(10). PMID: 29695768    Free PMC article.
Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma.
Maarten A Ligtenberg, Yago Pico de Coaña, +7 authors, Rolf Kiessling.
Mol Ther, 2018 May 08; 26(6). PMID: 29735366    Free PMC article.
Programmed cell death-1 and programmed cell death ligand-1 antibodies-induced dysthyroidism.
Jaafar Jaafar, Eugenio Fernandez, Heba Alwan, Jacques Philippe.
Endocr Connect, 2018 May 10; 7(5). PMID: 29739808    Free PMC article.
Immune checkpoint receptors: homeostatic regulators of immunity.
Antonio Riva, Shilpa Chokshi.
Hepatol Int, 2018 May 10; 12(3). PMID: 29740793    Free PMC article.
Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus.
Yantong Zhu, Xuebing Feng.
Stem Cell Res Ther, 2018 May 26; 9(1). PMID: 29793537    Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
Defining and Understanding Adaptive Resistance in Cancer Immunotherapy.
Tae Kon Kim, Roy S Herbst, Lieping Chen.
Trends Immunol, 2018 May 29; 39(8). PMID: 29802087    Free PMC article.
Highly Cited. Review.
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Kevin C Osum, Adam L Burrack, +8 authors, Brian T Fife.
Sci Rep, 2018 May 31; 8(1). PMID: 29844327    Free PMC article.
Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies.
Philipp Metzger, Sabrina V Kirchleitner, +5 authors, Peter Duewell.
Sci Rep, 2018 Jun 13; 8(1). PMID: 29892077    Free PMC article.
Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis.
Heidi Harjunpää, Stephen J Blake, +12 authors, Michele W L Teng.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900061    Free PMC article.
Construction of an anti-programmed death-ligand 1 chimeric antigen receptor and determination of its antitumor function with transduced cells.
Jiasen Xie, Zishan Zhou, Shunchang Jiao, Xiaokun Li.
Oncol Lett, 2018 Jun 22; 16(1). PMID: 29928397    Free PMC article.
Association of Immune-Related Adverse Events with Clinical Benefit in Patients with Advanced Non-Small-Cell Lung Cancer Treated with Nivolumab.
Yukihiro Toi, Shunichi Sugawara, +14 authors, Yoshihiro Honda.
Oncologist, 2018 Jun 24; 23(11). PMID: 29934411    Free PMC article.
Highly Cited.
Clinicopathological value of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) expression in synovium of patients with rheumatoid arthritis.
Kotaro Matsuda, Hiroaki Miyoshi, +6 authors, Koichi Ohshima.
Clin Exp Med, 2018 Jul 02; 18(4). PMID: 29961175
Minimal change disease associated with anti-PD1 immunotherapy: a case report.
Bixia Gao, Ningjing Lin, Suxia Wang, Yu Wang.
BMC Nephrol, 2018 Jul 05; 19(1). PMID: 29970032    Free PMC article.
Cancer Immune Therapy: Prognostic Significance and Implications for Therapy of PD-1 in BCG-Relapsing Bladder Cancer.
Neelam Mukherjee, Robert Svatek.
Ann Surg Oncol, 2018 Jul 05; 25(9). PMID: 29971674    Free PMC article.
Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond.
Emily M Lin, Jun Gong, Samuel J Klempner, Joseph Chao.
World J Gastroenterol, 2018 Jul 12; 24(25). PMID: 29991874    Free PMC article.
Microbial biomarkers for immune checkpoint blockade therapy against cancer.
Keishi Adachi, Koji Tamada.
J Gastroenterol, 2018 Jul 14; 53(9). PMID: 30003334    Free PMC article.
PD-L1 expression comparison between primary and relapsed non-small cell lung carcinoma using whole sections and clone SP263.
Enrico Munari, Giuseppe Zamboni, +13 authors, Giuseppe Bogina.
Oncotarget, 2018 Aug 14; 9(54). PMID: 30101000    Free PMC article.
Management of Brain Metastases in the New Era of Checkpoint Inhibition.
Adam Lauko, Bicky Thapa, Vyshak Alva Venur, Manmeet S Ahluwalia.
Curr Neurol Neurosci Rep, 2018 Aug 20; 18(10). PMID: 30121715
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.
Ying Wang, Lijing Su, +17 authors, Bruce Beutler.
Proc Natl Acad Sci U S A, 2018 Aug 29; 115(37). PMID: 30150374    Free PMC article.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.
Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül.
Front Immunol, 2018 Aug 31; 9. PMID: 30158932    Free PMC article.
Programmed Cell Death-1/Programmed Death-Ligand 1 Blockade Improves Survival of Animals with Sepsis: A Systematic Review and Meta-Analysis.
Qiang Zhang, Zhijiang Qi, Bo-Liu, Chun-Sheng Li.
Biomed Res Int, 2018 Aug 31; 2018. PMID: 30159323    Free PMC article.
Systematic Review.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.
Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar.
J Autoimmun, 2018 Sep 04; 95. PMID: 30174217    Free PMC article.
Clinical relevance of PD-L1 and PD-L2 overexpression in patients with esophageal squamous cell carcinoma.
Chih-Cheng Hsieh, Han-Shui Hsu, Anna Fen-Yau Li, Yann-Jang Chen.
J Thorac Dis, 2018 Sep 04; 10(7). PMID: 30174892    Free PMC article.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
Anti-PD1 and anti-PD-L1 in the treatment of metastatic melanoma.
Ester Simeone, Antonio M Grimaldi, Paolo A Ascierto.
Melanoma Manag, 2015 Feb 01; 2(1). PMID: 30190830    Free PMC article.
Immune-Related Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors.
Sabina Sandigursky, Adam Mor.
Curr Rheumatol Rep, 2018 Sep 08; 20(10). PMID: 30191417    Free PMC article.
New developments in immunotherapy for lymphoma.
Benjamin Heyman, Yiping Yang.
Cancer Biol Med, 2018 Sep 11; 15(3). PMID: 30197788    Free PMC article.
Combining immunotherapy with radiation therapy in thoracic oncology.
Shahed N Badiyan, Michael C Roach, +7 authors, Charles B Simone.
J Thorac Dis, 2018 Sep 13; 10(Suppl 21). PMID: 30206494    Free PMC article.
Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver.
Itziar Otano, David Escors, +14 authors, Mala K Maini.
Mol Ther, 2018 Sep 16; 26(11). PMID: 30217730    Free PMC article.
Circulating HLA-DR+CD4+ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis.
Asma Ahmed, Vasista Adiga, +6 authors, Annapurna Vyakarnam.
PLoS Pathog, 2018 Sep 20; 14(9). PMID: 30231065    Free PMC article.
Not All Immune Checkpoints Are Created Equal.
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger.
Front Immunol, 2018 Sep 21; 9. PMID: 30233564    Free PMC article.
Highly Cited. Review.
Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells.
Cherry S Leung, Kevin Y Yang, +7 authors, Kathy O Lui.
Genome Med, 2018 Sep 22; 10(1). PMID: 30236153    Free PMC article.
EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity.
Michael Peled, Matthew A Dragovich, +4 authors, Adam Mor.
J Immunol, 2018 Oct 03; 201(9). PMID: 30275048    Free PMC article.
Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer.
Qingyuan Li, Feng Li, +2 authors, Chengjian Qiao.
Med Sci Monit, 2018 Oct 14; 24. PMID: 30315148    Free PMC article.
Immune Checkpoints as Therapeutic Targets in Autoimmunity.
Christopher Paluch, Ana Mafalda Santos, +2 authors, Simon J Davis.
Front Immunol, 2018 Oct 24; 9. PMID: 30349540    Free PMC article.
[Mode of action, new targets and potential biomarkers in modern immunotherapy].
J Bedke, V Stühler, T Todenhöfer, A Stenzl.
Urologe A, 2018 Oct 24; 57(11). PMID: 30350128
Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.
Theinmozhi Arulraj, Debashis Barik.
PLoS One, 2018 Oct 26; 13(10). PMID: 30356330    Free PMC article.
Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again.
Samantha L Bucktrout, Jeffrey A Bluestone, Fred Ramsdell.
Genome Med, 2018 Nov 01; 10(1). PMID: 30376867    Free PMC article.
Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression.
Elena Gianchecchi, Alessandra Fierabracci.
Front Immunol, 2018 Nov 06; 9. PMID: 30386337    Free PMC article.
Highly Cited. Review.
2018 Nobel Prize in physiology or medicine.
Mark J Smyth, Michele Wl Teng.
Clin Transl Immunology, 2018 Nov 06; 7(10). PMID: 30386598    Free PMC article.
The Role of Co-Stimulatory Molecules in Chagas Disease.
Bruna F Pinto, Nayara I Medeiros, +4 authors, Juliana A S Gomes.
Cells, 2018 Nov 09; 7(11). PMID: 30405039    Free PMC article.
The Central Role of Inflammation Associated with Checkpoint Inhibitor Treatments.
Cristina Vajaitu, Carmen Cristina Draghici, +6 authors, Vlad Mihai Voiculescu.
J Immunol Res, 2018 Nov 13; 2018. PMID: 30417020    Free PMC article.
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
Jianqin Lu, Xiangsheng Liu, +6 authors, Andre E Nel.
ACS Nano, 2018 Nov 30; 12(11). PMID: 30481959    Free PMC article.
The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy.
Arabella Young, Zoe Quandt, Jeffrey A Bluestone.
Cancer Immunol Res, 2018 Dec 05; 6(12). PMID: 30510057    Free PMC article.
Immunological targets for cancer therapy: new recognition.
Michael R Shurin.
Immunotargets Ther, 2018 Dec 13; 7. PMID: 30538966    Free PMC article.
Human NK cells: surface receptors, inhibitory checkpoints, and translational applications.
Simona Sivori, Paola Vacca, +3 authors, Lorenzo Moretta.
Cell Mol Immunol, 2019 Feb 20; 16(5). PMID: 30778167    Free PMC article.
Highly Cited. Review.
Modulation of immune checkpoint molecule expression in mantle cell lymphoma.
Bonnie K Harrington, Esther Wheeler, +12 authors, Lapo Alinari.
Leuk Lymphoma, 2019 Mar 02; 60(10). PMID: 30821551    Free PMC article.
Application of PD-1 Blockade in Cancer Immunotherapy.
Xiaomo Wu, Zhongkai Gu, +4 authors, Xiaolong Liu.
Comput Struct Biotechnol J, 2019 Jun 18; 17. PMID: 31205619    Free PMC article.
Highly Cited. Review.
Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy.
Shixiang Wang, Li An Cowley, Xue-Song Liu.
Molecules, 2019 Sep 07; 24(18). PMID: 31487832    Free PMC article.
Highly Cited. Review.
Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor-related Pneumonitis. An Official American Thoracic Society Research Statement.
Catherine R Sears, Tobias Peikert, +11 authors, M Patricia Rivera.
Am J Respir Crit Care Med, 2019 Sep 14; 200(6). PMID: 31518182    Free PMC article.
Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance.
Georgia Fousteri, Amy Dave Jhatakia.
Viruses, 2019 Sep 25; 11(10). PMID: 31546586    Free PMC article.
Molecular Modeling Studies on the Binding Mode of the PD-1/PD-L1 Complex Inhibitors.
Suliman Almahmoud, Haizhen A Zhong.
Int J Mol Sci, 2019 Sep 25; 20(18). PMID: 31546905    Free PMC article.
Challenges and Opportunities for Childhood Cancer Drug Development.
Peter J Houghton, Raushan T Kurmasheva.
Pharmacol Rev, 2019 Sep 29; 71(4). PMID: 31558580    Free PMC article.
The mechanisms of acute interstitial nephritis in the era of immune checkpoint inhibitors in melanoma.
Tucci Marco, Passarelli Anna, +7 authors, Silvestris Franco.
Ther Adv Med Oncol, 2019 Oct 04; 11. PMID: 31579108    Free PMC article.
The Role of Immune Checkpoint Receptors in Regulating Immune Reactivity in Lupus.
Kun-Lin Lu, Ming-Ying Wu, +4 authors, Chun-Bing Chen.
Cells, 2019 Oct 11; 8(10). PMID: 31597242    Free PMC article.
CEACAM1 structure and function in immunity and its therapeutic implications.
Walter M Kim, Yu-Hwa Huang, Amit Gandhi, Richard S Blumberg.
Semin Immunol, 2019 Oct 13; 42. PMID: 31604530    Free PMC article.
[Recommendation of Diagnosis and Management for the Infections Related to Immune Checkpoint Inhibitors].
Minya Lu, Li Zhang, +7 authors, Li Zhang.
Zhongguo Fei Ai Za Zhi, 2019 Oct 28; 22(10). PMID: 31650951    Free PMC article.
[Management of Rheumatic Adverse Events Related to Immune Checkpoint Inhibitors].
Jiaxin Zhou, Qian Wang, +8 authors, Li Zhang.
Zhongguo Fei Ai Za Zhi, 2019 Oct 28; 22(10). PMID: 31650952    Free PMC article.
Immune Checkpoint Inhibition in Hodgkin Lymphoma.
Ryan H Moy, Anas Younes.
Hemasphere, 2018 Feb 16; 2(1). PMID: 31723749    Free PMC article.
Analysis of key clinical features for achieving complete remission in stage III and IV non-small cell lung cancer patients.
Takuya Aoki, Takeshi Akiba, +21 authors, Koichiro Asano.
Respir Res, 2019 Nov 23; 20(1). PMID: 31752884    Free PMC article.
Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells.
Kankana Bardhan, Halil-Ibrahim Aksoylar, +6 authors, Vassiliki A Boussiotis.
Sci Rep, 2019 Nov 23; 9(1). PMID: 31754127    Free PMC article.
Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor.
Xianguang Bai, Ming Yi, +2 authors, Kongming Wu.
Onco Targets Ther, 2019 Dec 07; 12. PMID: 31807028    Free PMC article.
Observational Molecular Case-Control Study of Genetic Polymorphisms 1 in Programmed Cell Death Protein-1 in Patients with Oral Lichen Planus
Janan Ghapanchi, Hamid Ghaderi, +6 authors, Ahmad Hasan Kalantari.
Asian Pac J Cancer Prev, 2019 Feb 26; 20(2). PMID: 30803202    Free PMC article.
High hopes and high honours for cancer immunotherapy.
Sophia Julia Häfner.
Biomed J, 2019 Dec 01; 42(5). PMID: 31783989    Free PMC article.
Immune checkpoint inhibitors win the 2018 Nobel Prize.
Pei-Wei Huang, John Wen-Cheng Chang.
Biomed J, 2019 Dec 01; 42(5). PMID: 31783990    Free PMC article.
Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway.
Grace Wakabayashi, Yu-Ching Lee, +3 authors, Yun Yen.
J Biomed Sci, 2019 Dec 06; 26(1). PMID: 31801525    Free PMC article.
Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors.
Sophia C Weinmann, David S Pisetsky.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816080    Free PMC article.
Harnessing NK Cells for Cancer Treatment.
Paola Minetto, Fabio Guolo, +7 authors, Emanuela Marcenaro.
Front Immunol, 2019 Dec 24; 10. PMID: 31867006    Free PMC article.
Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.
Kevin S Cashman, Scott A Jenks, +6 authors, Iñaki Sanz.
Immunol Rev, 2019 Nov 23; 292(1). PMID: 31755562    Free PMC article.
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Yunlong Zhao, Calvin K Lee, +8 authors, Enfu Hui.
Immunity, 2019 Nov 24; 51(6). PMID: 31757674    Free PMC article.
Neurological Immune Related Adverse Events Associated with Nivolumab, Ipilimumab, and Pembrolizumab Therapy-Review of the Literature and Future Outlook.
Nora Möhn, Gernot Beutel, +3 authors, Thomas Skripuletz.
J Clin Med, 2019 Oct 28; 8(11). PMID: 31653079    Free PMC article.
Management of immune checkpoint inhibitor-related rheumatic adverse events.
Jiaxin Zhou, Hanping Wang, +8 authors, Li Zhang.
Thorac Cancer, 2019 Nov 26; 11(1). PMID: 31762209    Free PMC article.
Systematic Review.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
Kazushige Yoshida, Masanori Okamoto, +13 authors, Naoto Saito.
BMC Cancer, 2020 Jan 10; 20(1). PMID: 31914969    Free PMC article.
Giant cell myocarditis with central diabetes insipidus: A case report.
Shogo Yamaguchi, Akinori Sawamura, +12 authors, Toyoaki Murohara.
J Cardiol Cases, 2020 Jan 15; 21(1). PMID: 31933698    Free PMC article.
Combined induction with anti-PD-1 and anti-CTLA-4 antibodies provides synergistic antitumor effects in DC-CIK cells in renal carcinoma cell lines.
Zhaohu Yuan, Huikuan Yang, Yaming Wei.
Int J Clin Exp Pathol, 2020 Jan 15; 12(1). PMID: 31933726    Free PMC article.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Florian Wiede, Kun-Hui Lu, +16 authors, Tony Tiganis.
EMBO J, 2019 Dec 06; 39(2). PMID: 31803974    Free PMC article.
Odds ratio of programmed cell death-1 or ligand 1 inhibitor-related endocrine dysfunction in patients with lung cancer: A systematic review and meta-analysis.
Jian Xie, Zewen Zhang, +4 authors, Yuan Tian.
Medicine (Baltimore), 2019 Dec 20; 98(50). PMID: 31852114    Free PMC article.
Systematic Review.
Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review.
Shaheen Khan, David E Gerber.
Semin Cancer Biol, 2019 Jul 23; 64. PMID: 31330185    Free PMC article.
Prevalence of programmed death-1 ligand-1 (PD-L1) and infiltrating lymphocytes in human gastric carcinogenesis.
Zhonghua Liu, Yufang Wang, +3 authors, Tao Wang.
Int J Clin Exp Pathol, 2017 Dec 01; 10(12). PMID: 31966537    Free PMC article.
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Tijana Martinov, Brian T Fife.
Ann N Y Acad Sci, 2019 Apr 27; 1461(1). PMID: 31025378    Free PMC article.
Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?
Pilar M Lanuza, Cecilia Pesini, +3 authors, Julian Pardo.
Front Immunol, 2020 Jan 31; 10. PMID: 31998304    Free PMC article.
Current status of the clinical use of PD-1/PD-L1 inhibitors: a questionnaire survey of oncologists in China.
Bicheng Zhang, Yuxiao Song, +3 authors, Jun Wang.
BMC Cancer, 2020 Feb 02; 20(1). PMID: 32005140    Free PMC article.
Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC.
Kelvin Anderson, Nathan Ryan, +3 authors, Steve Oghumu.
Front Immunol, 2020 Feb 06; 10. PMID: 32010142    Free PMC article.
Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma.
Taisuke Irifuku, Ayaka Satoh, +2 authors, Takao Masaki.
CEN Case Rep, 2019 Oct 13; 9(1). PMID: 31605271    Free PMC article.
Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity.
Huan Deng, Songwei Tan, +7 authors, Zhiping Zhang.
Acta Pharm Sin B, 2020 Feb 23; 10(2). PMID: 32082979    Free PMC article.
Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population.
Takuji Iwamoto, Katsunori Ikari, +6 authors, Naoyuki Kamatani.
J Hum Genet, 2007 May 01; 52(6). PMID: 17468813
Single injection of IL-12 coacervate as an effective therapy against B16-F10 melanoma in mice.
Mintai P Hwang, Ronald J Fecek, +2 authors, Yadong Wang.
J Control Release, 2019 Dec 24; 318. PMID: 31866503    Free PMC article.
Structure and Optimization of Checkpoint Inhibitors.
Sarah L Picardo, Jeffrey Doi, Aaron R Hansen.
Cancers (Basel), 2019 Dec 28; 12(1). PMID: 31877721    Free PMC article.
Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis.
Laura C Cappelli, Mekha A Thomas, +2 authors, Erika Darrah.
Immunol Rev, 2020 Jan 14; 294(1). PMID: 31930524    Free PMC article.
Predictive and prognostic value of PDL1 protein expression in breast cancer patients in neoadjuvant setting.
Ziping Wu, Lei Zhang, +7 authors, Jinsong Lu.
Cancer Biol Ther, 2019 Mar 15; 20(6). PMID: 30866717    Free PMC article.
The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.
Katrin Neumann, Annett Ostmann, +5 authors, Gisa Tiegs.
Sci Rep, 2019 Feb 16; 9(1). PMID: 30765734    Free PMC article.
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma.
Megumi Goto, Kenji Chamoto, +17 authors, Tasuku Honjo.
Sci Rep, 2019 Jul 14; 9(1). PMID: 31300681    Free PMC article.
Recommendation for the diagnosis and management of immune checkpoint inhibitor related infections.
Minya Lu, Li Zhang, +7 authors, Li Zhang.
Thorac Cancer, 2020 Jan 24; 11(3). PMID: 31970940    Free PMC article.
Autoimmune haemolytic anaemia in a patient with advanced lung adenocarcinoma and chronic lymphocytic leukaemia receiving nivolumab and intravenous immunoglobulin.
Sandra D Algaze, Wungki Park, Thomas J Harrington, Raja Mudad.
BMJ Case Rep, 2018 Mar 11; 2018. PMID: 29523604    Free PMC article.
A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma.
Y Cai, Fei Wang, +3 authors, Z Sun.
Invest New Drugs, 2018 Oct 29; 37(5). PMID: 30368626
Class II MHC antigen processing in immune tolerance and inflammation.
Mollie M Jurewicz, Lawrence J Stern.
Immunogenetics, 2018 Nov 14; 71(3). PMID: 30421030    Free PMC article.
Immunotherapy transforms cancer treatment.
Neeha Zaidi, Elizabeth M Jaffee.
J Clin Invest, 2018 Dec 07; 129(1). PMID: 30507614    Free PMC article.
IL-10 producing CD8+ CD122+ PD-1+ regulatory T cells are expanded by dendritic cells silenced for Allograft Inflammatory Factor-1.
Diana M Elizondo, Temesgen E Andargie, +3 authors, Michael W Lipscomb.
J Leukoc Biol, 2018 Dec 05; 105(1). PMID: 30512224    Free PMC article.
Autoimmunity and Cancer, the Paradox Comorbidities Challenging Therapy in the Context of Preexisting Autoimmunity.
Julio C Valencia, Nkolika Egbukichi, Rebecca A Erwin-Cohen.
J Interferon Cytokine Res, 2018 Dec 19; 39(1). PMID: 30562133    Free PMC article.
Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing.
Zihai Li, Wenru Song, Mark Rubinstein, Delong Liu.
J Hematol Oncol, 2018 Dec 24; 11(1). PMID: 30577797    Free PMC article.
Highly Cited. Review.
Profiling Preexisting Antibodies in Patients Treated With Anti-PD-1 Therapy for Advanced Non-Small Cell Lung Cancer.
Yukihiro Toi, Shunichi Sugawara, +15 authors, Yoshihiro Honda.
JAMA Oncol, 2018 Dec 28; 5(3). PMID: 30589930    Free PMC article.
Highly Cited.
Regulation of GVHD and GVL Activity via PD-L1 Interaction With PD-1 and CD80.
Kaniel Cassady, Paul J Martin, Defu Zeng.
Front Immunol, 2019 Jan 10; 9. PMID: 30622541    Free PMC article.
Adverse events associated with immune checkpoint inhibitor treatment for cancer.
Khashayar Esfahani, Nicholas Meti, Wilson H Miller, Marie Hudson.
CMAJ, 2019 Jan 16; 191(2). PMID: 30642824    Free PMC article.
Roles, function and relevance of LAG3 in HIV infection.
Colin G Graydon, Allison L Balasko, Keith R Fowke.
PLoS Pathog, 2019 Jan 18; 15(1). PMID: 30653605    Free PMC article.
Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells.
Christine E Nelson, Lauren J Mills, +6 authors, Vaiva Vezys.
Proc Natl Acad Sci U S A, 2019 Jan 27; 116(7). PMID: 30679280    Free PMC article.
PDL1 Fusion Protein Protects Against Experimental Cerebral Malaria via Repressing Over-Reactive CD8+ T Cell Responses.
Jun Wang, Yue Li, +8 authors, Kun Yang.
Front Immunol, 2019 Jan 30; 9. PMID: 30693001    Free PMC article.
Cardiovascular toxicities associated with immune checkpoint inhibitors.
Jiun-Ruey Hu, Roberta Florido, +7 authors, Javid Moslehi.
Cardiovasc Res, 2019 Feb 05; 115(5). PMID: 30715219    Free PMC article.
Highly Cited. Review.
Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs.
Betul Gok Yavuz, Gurcan Gunaydin, +4 authors, Dicle Guc.
Sci Rep, 2019 Mar 01; 9(1). PMID: 30816272    Free PMC article.
Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients.
Silvia Medina, Susana Sainz de la Maza, +9 authors, Luisa M Villar.
Ann Clin Transl Neurol, 2019 Mar 09; 6(2). PMID: 30847367    Free PMC article.
Diabetes mellitus secondary to treatment with immune checkpoint inhibitors.
V Venetsanaki, A Boutis, A Chrisoulidou, P Papakotoulas.
Curr Oncol, 2019 Mar 12; 26(1). PMID: 30853817    Free PMC article.
PD‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling.
Anyuan Zheng, Fen Li, +6 authors, Zezhang Tao.
Oncol Rep, 2019 Mar 14; 41(5). PMID: 30864729    Free PMC article.
Cat and Mouse: HIV Transcription in Latency, Immune Evasion and Cure/Remission Strategies.
Aurélie Delannoy, Mikaël Poirier, Brendan Bell.
Viruses, 2019 Mar 21; 11(3). PMID: 30889861    Free PMC article.
Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.
Yu Fujita, Roberto Tinoco, +2 authors, Ze'ev A Ronai.
Trends Mol Med, 2019 Mar 23; 25(5). PMID: 30898473    Free PMC article.
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Spencer C Wei, Roshan Sharma, +8 authors, James P Allison.
Immunity, 2019 Mar 31; 50(4). PMID: 30926234    Free PMC article.
The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Danqing Chen, Shuguang Tan, +12 authors, George F Gao.
iScience, 2019 Apr 06; 14. PMID: 30952089    Free PMC article.
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy.
Xinyi Tu, Bo Qin, +16 authors, Zhenkun Lou.
Mol Cell, 2019 May 06; 74(6). PMID: 31053471    Free PMC article.
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance.
Günther Schönrich, Martin J Raftery.
Front Cell Infect Microbiol, 2019 Jul 03; 9. PMID: 31263684    Free PMC article.
Highly Cited. Review.
Neoantigen vaccine: an emerging tumor immunotherapy.
Miao Peng, Yongzhen Mo, +10 authors, Zhaoyang Zeng.
Mol Cancer, 2019 Aug 25; 18(1). PMID: 31443694    Free PMC article.
Highly Cited. Review.
Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers.
Yves Lecarpentier, Olivier Schussler, Jean-Louis Hébert, Alexandre Vallée.
Front Oncol, 2019 Dec 06; 9. PMID: 31803621    Free PMC article.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges.
Kei Kunimasa, Taichiro Goto.
Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413    Free PMC article.
Association Between Skin Reaction and Clinical Benefit in Patients Treated with Anti-Programmed Cell Death 1 Monotherapy for Advanced Non-Small Cell Lung Cancer.
Mari Aso, Yukihiro Toi, +15 authors, Shunichi Sugawara.
Oncologist, 2020 Mar 13; 25(3). PMID: 32162801    Free PMC article.
Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes.
Tijana Martinov, Linnea A Swanson, +10 authors, Brian T Fife.
J Immunol, 2019 Jul 22; 203(4). PMID: 31324724    Free PMC article.
The past, present, and future of costimulation blockade in organ transplantation.
Paul M Schroder, Zachary W Fitch, +3 authors, Stuart J Knechtle.
Curr Opin Organ Transplant, 2019 Jun 04; 24(4). PMID: 31157670    Free PMC article.
Kidney Complications of Immune Checkpoint Inhibitors: A Review.
Roman Shingarev, Ilya G Glezerman.
Am J Kidney Dis, 2019 Jul 16; 74(4). PMID: 31303350    Free PMC article.
Immune checkpoint inhibitors of PD-L1 as cancer therapeutics.
Akintunde Akinleye, Zoaib Rasool.
J Hematol Oncol, 2019 Sep 07; 12(1). PMID: 31488176    Free PMC article.
Highly Cited. Review.
Assessment of the Safety of Pembrolizumab in Patients With HIV and Advanced Cancer-A Phase 1 Study.
Thomas S Uldrick, Priscila H Gonçalves, +19 authors, Cancer Immunotherapy Trials Network (CITN)-12 Study Team.
JAMA Oncol, 2019 Jun 04; 5(9). PMID: 31154457    Free PMC article.
Highly Cited.
Mouse Systems Genetics as a Prelude to Precision Medicine.
Hao Li, Johan Auwerx.
Trends Genet, 2020 Feb 11; 36(4). PMID: 32037011    Free PMC article.
The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses.
Helge Frebel, Annette Oxenius.
Trends Immunol, 2013 Jan 22; 34(5). PMID: 23333205    Free PMC article.
Foxp3⁺ T(reg) cells in humoral immunity.
James B Wing, Shimon Sakaguchi.
Int Immunol, 2013 Dec 11; 26(2). PMID: 24324208    Free PMC article.
Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits.
Verónica C Martínez Allo, Vanesa Hauk, +18 authors, Marta A Toscano.
Proc Natl Acad Sci U S A, 2020 Mar 13; 117(12). PMID: 32161138    Free PMC article.
Rebalancing Immune Homeostasis to Treat Autoimmune Diseases.
David A Horwitz, Tarek M Fahmy, Ciriaco A Piccirillo, Antonio La Cava.
Trends Immunol, 2019 Oct 12; 40(10). PMID: 31601519    Free PMC article.
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.
Alexandra Schnell, Lloyd Bod, Asaf Madi, Vijay K Kuchroo.
Cell Res, 2020 Jan 25; 30(4). PMID: 31974523    Free PMC article.
Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy.
Chongxian Pan, Hongtao Liu, +4 authors, Lei Zheng.
J Hematol Oncol, 2020 Apr 05; 13(1). PMID: 32245497    Free PMC article.
T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.
Jonatan Tuncel, Christophe Benoist, Diane Mathis.
J Exp Med, 2019 Apr 17; 216(6). PMID: 30988052    Free PMC article.
Development of immune checkpoint therapy for cancer.
Jill M Fritz, Michael J Lenardo.
J Exp Med, 2019 May 10; 216(6). PMID: 31068379    Free PMC article.
Highly Cited. Review.
A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia.
Jason D Lickliter, Hui K Gan, +17 authors, Tarek Meniawy.
Drug Des Devel Ther, 2020 Apr 08; 14. PMID: 32256049    Free PMC article.
Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?
Thaiz Rivera Vargas, Lionel Apetoh.
Front Immunol, 2019 Jun 14; 10. PMID: 31191545    Free PMC article.
Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis.
Karine Chemin, Christina Gerstner, Vivianne Malmström.
Front Immunol, 2019 Mar 28; 10. PMID: 30915067    Free PMC article.
Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors.
Franziska Eckert, Kerstin Zwirner, +3 authors, Stephan M Huber.
Front Immunol, 2019 Apr 02; 10. PMID: 30930892    Free PMC article.
FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy.
Xin Chen, Xiaomin Song, Kang Li, Tong Zhang.
Front Immunol, 2019 Mar 14; 10. PMID: 30863404    Free PMC article.
Highly Cited. Review.
The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer.
Nanna Jørgensen, Gry Persson, Thomas Vauvert F Hviid.
Front Immunol, 2019 May 28; 10. PMID: 31134056    Free PMC article.
Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis.
Iris Lavon, Coral Heli, +2 authors, Adi Vaknin-Dembinsky.
Front Immunol, 2019 May 28; 10. PMID: 31134049    Free PMC article.
A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma-A Proof of Antigen Discovery Feasibility in Three Patients.
Michal Bassani-Sternberg, Antonia Digklia, +15 authors, Lana E Kandalaft.
Front Immunol, 2019 Aug 24; 10. PMID: 31440238    Free PMC article.
TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2.
Paramita Baruah, Jessica Bullenkamp, +3 authors, Ingrid E Dumitriu.
Front Immunol, 2019 Aug 06; 10. PMID: 31379843    Free PMC article.
TIGIT as an emerging immune checkpoint.
H Harjunpää, C Guillerey.
Clin Exp Immunol, 2019 Dec 13; 200(2). PMID: 31828774    Free PMC article.
HX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic properties.
Jibin Zhang, Ying Huang, Gan Xi, Faming Zhang.
MAbs, 2020 Feb 29; 12(1). PMID: 32106752    Free PMC article.
The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PD-L1 levels on CNS cells.
Camille L Pittet, Jia Newcombe, Jack P Antel, Nathalie Arbour.
Glia, 2011 Mar 02; 59(5). PMID: 21360758    Free PMC article.
Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma.
Akiko Arakawa, Sigrid Vollmer, +5 authors, Jörg C Prinz.
Front Immunol, 2019 Jul 06; 10. PMID: 31275310    Free PMC article.
PD/1-PD-Ls Checkpoint: Insight on the Potential Role of NK Cells.
Silvia Pesce, Marco Greppi, +5 authors, Emanuela Marcenaro.
Front Immunol, 2019 Jun 20; 10. PMID: 31214193    Free PMC article.
Highly Cited. Review.
Modeling clear cell renal cell carcinoma and therapeutic implications.
Melissa M Wolf, W Kimryn Rathmell, Kathryn E Beckermann.
Oncogene, 2020 Mar 04; 39(17). PMID: 32123314    Free PMC article.
Renal Effects after Pembrolizumab Treatment for Non-small Cell Lung Carcinoma.
Rikako Oki, Yosuke Hirakawa, +7 authors, Masaomi Nangaku.
Intern Med, 2019 Dec 10; 59(7). PMID: 31813918    Free PMC article.
T cell costimulation, checkpoint inhibitors and anti-tumor therapy.
Dipankar Nandi, Sanmoy Pathak, +6 authors, Vijayamahantesh.
J Biosci, 2020 Apr 30; 45. PMID: 32345776
Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA.
Pierre Tannig, Antonia Sophia Peter, +5 authors, Vladimir Temchura.
Vaccines (Basel), 2020 Jan 18; 8(1). PMID: 31947643    Free PMC article.
Current issues and perspectives in PD-1 blockade cancer immunotherapy.
Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo.
Int J Clin Oncol, 2020 Jan 05; 25(5). PMID: 31900651    Free PMC article.
Cancer-induced immunosuppression can enable effectiveness of immunotherapy through bistability generation: A mathematical and computational examination.
Victor Garcia, Sebastian Bonhoeffer, Feng Fu.
J Theor Biol, 2020 Feb 10; 492. PMID: 32035826    Free PMC article.
Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy.
Robert D Carlson, John C Flickinger, Adam E Snook.
Toxins (Basel), 2020 Apr 15; 12(4). PMID: 32283684    Free PMC article.
Combination Strategies for Immune-Checkpoint Blockade and Response Prediction by Artificial Intelligence.
Florian Huemer, Michael Leisch, +4 authors, Richard Greil.
Int J Mol Sci, 2020 Apr 25; 21(8). PMID: 32325898    Free PMC article.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
Rheumatic Manifestations in Patients Treated with Immune Checkpoint Inhibitors.
Konstantinos Melissaropoulos, Kalliopi Klavdianou, +3 authors, Dimitrios Daoussis.
Int J Mol Sci, 2020 May 15; 21(9). PMID: 32403289    Free PMC article.
CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.
Yang Liu, Yuting Gao, Huiqin Hao, Tiezheng Hou.
FEBS Open Bio, 2020 Apr 24; 10(6). PMID: 32324337    Free PMC article.
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
Xiaozheng Xu, Bowen Hou, +10 authors, Enfu Hui.
J Cell Biol, 2020 May 22; 219(6). PMID: 32437509    Free PMC article.
Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28.
F R Mariotti, L Quatrini, +5 authors, L Moretta.
Br J Pharmacol, 2020 Apr 27; 177(13). PMID: 32335915    Free PMC article.
Pancreatic Cancer and Its Microenvironment-Recent Advances and Current Controversies.
Kinga B Stopa, Agnieszka A Kusiak, +2 authors, Monika A Jakubowska.
Int J Mol Sci, 2020 May 07; 21(9). PMID: 32370075    Free PMC article.
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.
Zhenzhen Fan, Yahui Tian, +13 authors, Liang Chen.
EMBO Mol Med, 2020 May 12; 12(6). PMID: 32391629    Free PMC article.
Adjuvant Effect of Toll-Like Receptor 9 Activation on Cancer Immunotherapy Using Checkpoint Blockade.
Yu-Chen Chuang, Jen-Chih Tseng, +3 authors, Tsung-Hsien Chuang.
Front Immunol, 2020 Jun 18; 11. PMID: 32547560    Free PMC article.
Implications of the HDAC6-ERK1 feed-forward loop in immunotherapy.
Jheng-Yu Wu, Niko Moses, Wenlong Bai, Xiaohong Mary Zhang.
J Immunol Sci, 2018 Jan 01; 2(3). PMID: 30854521    Free PMC article.
Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors.
Junko Hori, Tomoyuki Kunishige, Yuji Nakano.
Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486493    Free PMC article.
TIM3 comes of age as an inhibitory receptor.
Yochai Wolf, Ana C Anderson, Vijay K Kuchroo.
Nat Rev Immunol, 2019 Nov 05; 20(3). PMID: 31676858    Free PMC article.
Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression.
Lalit Batra, Pradeep Shrestha, +9 authors, Esma S Yolcu.
J Immunol, 2020 Apr 08; 204(10). PMID: 32253240    Free PMC article.
Immune reaction and regulation in transplantation based on pluripotent stem cell technology.
Ryo Otsuka, Haruka Wada, Tomoki Murata, Ken-Ichiro Seino.
Inflamm Regen, 2020 Jul 09; 40. PMID: 32636970    Free PMC article.
Programmed Death Ligand 1: A Poor Prognostic Marker in Endometrial Carcinoma.
Mianxin Chew, Yin Ping Wong, +3 authors, Geok Chin Tan.
Diagnostics (Basel), 2020 Jun 18; 10(6). PMID: 32545177    Free PMC article.
PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond.
Yasumasa Ishida.
Cells, 2020 Jun 05; 9(6). PMID: 32492969    Free PMC article.
Immune checkpoint inhibitor-induced musculoskeletal manifestations. A multicentre prospective study.
Dimitrios Daoussis, Konstantinos Melissaropoulos, +7 authors, Haralabos Kalofonos.
Mediterr J Rheumatol, 2020 Jul 18; 31(2). PMID: 32676566    Free PMC article.
The Role of Immunomodulatory Receptors in the Pathogenesis of HIV Infection: A Therapeutic Opportunity for HIV Cure?
Hui Chen, Maha Moussa, Marta Catalfamo.
Front Immunol, 2020 Jul 28; 11. PMID: 32714317    Free PMC article.
Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy.
Caitlin C Zebley, Stephen Gottschalk, Ben Youngblood.
Trends Immunol, 2020 Jul 07; 41(8). PMID: 32624330    Free PMC article.
Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events.
Sandra M Herrmann, Mark A Perazella.
Kidney Int Rep, 2020 Aug 11; 5(8). PMID: 32775813    Free PMC article.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.
Yuanyuan Zhang, Zemin Zhang.
Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154    Free PMC article.
PD-1 immunobiology in systemic lupus erythematosus.
Colleen S Curran, Sarthak Gupta, Ignacio Sanz, Elad Sharon.
J Autoimmun, 2018 Nov 07; 97. PMID: 30396745    Free PMC article.
Strategies for Deliberate Induction of Immune Tolerance in Liver Transplantation: From Preclinical Models to Clinical Application.
Naoki Tanimine, Masahiro Ohira, +4 authors, Hideki Ohdan.
Front Immunol, 2020 Aug 28; 11. PMID: 32849546    Free PMC article.
Critical roles of super-enhancers in the pathogenesis of autoimmune diseases.
Kaoru Yamagata, Shingo Nakayamada, Yoshiya Tanaka.
Inflamm Regen, 2020 Sep 15; 40. PMID: 32922569    Free PMC article.
Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis.
Chenxin Qie, Jingwei Jiang, +4 authors, Jun Liu.
Theranostics, 2020 Sep 16; 10(23). PMID: 32929361    Free PMC article.
Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes.
Marika Falcone, Georgia Fousteri.
Front Endocrinol (Lausanne), 2020 Sep 26; 11. PMID: 32973682    Free PMC article.
2018 Nobel Prize in medicine awarded to cancer immunotherapy: Immune checkpoint blockade - A personal account.
Xingxing Zang.
Genes Dis, 2018 Dec 29; 5(4). PMID: 30591930    Free PMC article.
Immune checkpoint therapy and type 1 diabetes.
Hiroshi Ikegami, Yumiko Kawabata, Shinsuke Noso.
Diabetol Int, 2016 Jul 05; 7(3). PMID: 30603267    Free PMC article.
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28.
Leonardo Chicaybam, Prasad S Adusumilli.
Transl Cancer Res, 2017 Aug 01; 6(Suppl 6). PMID: 30613486    Free PMC article.
Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer.
Jennifer A Bridge, James C Lee, +2 authors, Jeffrey A Bluestone.
Front Med (Lausanne), 2019 Jan 12; 5. PMID: 30631766    Free PMC article.
Heart failure in cancer: role of checkpoint inhibitors.
Murilo Delgobo, Stefan Frantz.
J Thorac Dis, 2019 Feb 01; 10(Suppl 35). PMID: 30701100    Free PMC article.
Renal toxicities associated with pembrolizumab.
Hassan Izzedine, Alexis Mathian, +16 authors, Isabelle Brocheriou.
Clin Kidney J, 2019 Feb 13; 12(1). PMID: 30746132    Free PMC article.
Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab.
Panagiotis I Georgianos, Vasilios Vaios, +5 authors, Pantelis E Zebekakis.
Case Rep Nephrol, 2019 Feb 19; 2019. PMID: 30775040    Free PMC article.
Immune checkpoint inhibitors: Advances and impact in neuro-oncology.
Jawad Fares, Mohamad Y Fares, Youssef Fares.
Surg Neurol Int, 2019 Feb 21; 10. PMID: 30783540    Free PMC article.
Complete response to pembrolizumab in a patient with metastatic colon cancer with microsatellite instability and a history of Guillain-Barre syndrome.
Chongkai Wang, Jaideep Sandhu, Marwan Fakih.
J Gastrointest Oncol, 2019 Feb 23; 10(1). PMID: 30788172    Free PMC article.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma.
Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns.
Front Oncol, 2019 Mar 12; 8. PMID: 30854331    Free PMC article.
Therapeutic targeting of immune checkpoints with small molecule inhibitors.
Wade M Smith, Ian J Purvis, +7 authors, Swapna Asuthkar.
Am J Transl Res, 2019 Mar 23; 11(2). PMID: 30899360    Free PMC article.
Managing cardiotoxicity associated with immune checkpoint inhibitors.
Sireesha Upadhrasta, Hadi Elias, Keval Patel, Lei Zheng.
Chronic Dis Transl Med, 2019 Apr 18; 5(1). PMID: 30993259    Free PMC article.
Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers.
Kazushige Yoshida, Masanori Okamoto, +14 authors, Naoto Saito.
Onco Targets Ther, 2019 May 02; 12. PMID: 31040694    Free PMC article.
The role of pembrolizumab in relapsed/refractory primary mediastinal large B-cell lymphoma.
Sarah Tomassetti, Robert Chen, Savita Dandapani.
Ther Adv Hematol, 2019 May 02; 10. PMID: 31040936    Free PMC article.
Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.
Daniele Lecis, Sabina Sangaletti, Mario P Colombo, Claudia Chiodoni.
Cancers (Basel), 2019 May 08; 11(5). PMID: 31060225    Free PMC article.
Incidence risk of PD-1/PD-L1 related diarrhea in non-small cell lung cancer (NSCLC) patients: a systematic review and meta-analysis.
Caiqing Zhang, Shuisheng Zhang, +5 authors, Yuan Tian.
Cancer Manag Res, 2019 May 24; 11. PMID: 31118808    Free PMC article.
Myocarditis in Humans and in Experimental Animal Models.
Przemysław Błyszczuk.
Front Cardiovasc Med, 2019 Jun 04; 6. PMID: 31157241    Free PMC article.
Acute Interstitial Nephritis With Karyomegalic Epithelial Cells After Nivolumab Treatment-Two Case Reports.
Masaki Ryuzaki, Hirobumi Tokuyama, +7 authors, Hiroshi Itoh.
Clin Med Insights Case Rep, 2019 Jun 22; 12. PMID: 31223235    Free PMC article.
Immune-Related Adverse Events: A Case-Based Approach.
Caoilfhionn Connolly, Kalindi Bambhania, Jarushka Naidoo.
Front Oncol, 2019 Jul 12; 9. PMID: 31293970    Free PMC article.
Management of Adverse Events in Cancer Patients Treated With PD-1/PD-L1 Blockade: Focus on Asian Populations.
Jiqiao Yang, Xiujing He, +2 authors, Hubing Shi.
Front Pharmacol, 2019 Jul 18; 10. PMID: 31312140    Free PMC article.
Checkpoint inhibition in advanced gastroesophageal cancer: clinical trial data, molecular subtyping, predictive biomarkers, and the potential of combination therapies.
Jeremy Chuang, Joseph Chao, +2 authors, Jun Gong.
Transl Gastroenterol Hepatol, 2019 Sep 29; 4. PMID: 31559344    Free PMC article.
LAG-3: from molecular functions to clinical applications.
Takumi Maruhashi, Daisuke Sugiura, Il-Mi Okazaki, Taku Okazaki.
J Immunother Cancer, 2020 Sep 16; 8(2). PMID: 32929051    Free PMC article.
Revisiting the PD-1 pathway.
Nikolaos Patsoukis, Qi Wang, Laura Strauss, Vassiliki A Boussiotis.
Sci Adv, 2020 Sep 20; 6(38). PMID: 32948597    Free PMC article.
Glioma escape signature and clonal development under immune pressure.
Cecile L Maire, Malte Mohme, +14 authors, Katrin Lamszus.
J Clin Invest, 2020 Jul 01; 130(10). PMID: 32603315    Free PMC article.
Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates.
Zilong Wang, Changyu Jiang, +7 authors, Ru-Rong Ji.
Sci Transl Med, 2020 Feb 23; 12(531). PMID: 32075945    Free PMC article.
Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis.
Stephanie M Slevin, Lucy C Garner, +18 authors, Satish Keshav.
J Crohns Colitis, 2020 Mar 18; 14(10). PMID: 32179884    Free PMC article.
Why the Outcome of Anti-Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers.
Jing H Wang.
Bioessays, 2020 Aug 09; 42(10). PMID: 32767371    Free PMC article.
Pneumonitis Induced by Immune Checkpoint Inhibitors: From Clinical Data to Translational Investigation.
Shicong Zhu, Yang Fu, +2 authors, Jun Wang.
Front Oncol, 2020 Oct 13; 10. PMID: 33042827    Free PMC article.
Monoclonal Antibodies in Cancer Therapy.
David Zahavi, Louis Weiner.
Antibodies (Basel), 2020 Jul 24; 9(3). PMID: 32698317    Free PMC article.
Management of Immune Checkpoint Inhibitor Toxicities.
Quentin Durrechou, Charlotte Domblides, +5 authors, Amaury Daste.
Cancer Manag Res, 2020 Oct 17; 12. PMID: 33061607    Free PMC article.
PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia.
Changyu Jiang, Zilong Wang, +6 authors, Ru-Rong Ji.
iScience, 2020 Oct 22; 23(10). PMID: 33083737    Free PMC article.
Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.
Weilei Hu, Guosheng Wang, +2 authors, Ming You.
iScience, 2020 Oct 22; 23(10). PMID: 33083746    Free PMC article.
Immune-related signature predicts the prognosis and immunotherapy benefit in bladder cancer.
Yejinpeng Wang, Liang Chen, +6 authors, Xinghuan Wang.
Cancer Med, 2020 Aug 26; 9(20). PMID: 32841548    Free PMC article.
First-Line Immune-Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Current Landscape and Future Progress.
Zhangfeng Huang, Wenhao Su, +6 authors, Wenjie Jiao.
Front Pharmacol, 2020 Oct 30; 11. PMID: 33117170    Free PMC article.
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Rossana Franzin, Giuseppe Stefano Netti, +5 authors, Elena Ranieri.
Front Immunol, 2020 Nov 10; 11. PMID: 33162990    Free PMC article.
The effects of age and systemic metabolism on anti-tumor T cell responses.
Jefte M Drijvers, Arlene H Sharpe, Marcia C Haigis.
Elife, 2020 Nov 11; 9. PMID: 33170123    Free PMC article.
Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance.
Priya Veluswamy, Max Wacker, Maximilian Scherner, Jens Wippermann.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142805    Free PMC article.
Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction.
Haiting Ma, Jacob F Jeppesen, Rudolf Jaenisch.
Cell Rep Med, 2020 Nov 19; 1(6). PMID: 33205073    Free PMC article.
Coexisting TIF1γ-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis.
Yu Nakanishi, Kakuhiro Yamaguchi, +11 authors, Noboru Hattori.
Intern Med, 2020 Jun 26; 59(20). PMID: 32581161    Free PMC article.
The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy.
Linda Quatrini, Francesca Romana Mariotti, +3 authors, Lorenzo Moretta.
Cancers (Basel), 2020 Nov 12; 12(11). PMID: 33172030    Free PMC article.
Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus.
Chrissy Bolton, Yifan Chen, +8 authors, Joel Smith.
Drugs R D, 2020 Sep 23; 20(4). PMID: 32960413    Free PMC article.
Systematic Review.
Co-inhibitory Receptor Signaling in T-Cell-Mediated Autoimmune Glomerulonephritis.
Kei Nagai.
Front Med (Lausanne), 2020 Dec 01; 7. PMID: 33251233    Free PMC article.
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
Tim Magnus, Bettina Schreiner, +8 authors, Heinz Wiendl.
J Neurosci, 2005 Mar 11; 25(10). PMID: 15758163    Free PMC article.
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.
Pavan Brahmamdam, Shigeaki Inoue, +3 authors, Richard S Hotchkiss.
J Leukoc Biol, 2010 May 21; 88(2). PMID: 20483923    Free PMC article.
Highly Cited.
Developing combination strategies using PD-1 checkpoint inhibitors to treat cancer.
Emmett V Schmidt.
Semin Immunopathol, 2018 Oct 31; 41(1). PMID: 30374524    Free PMC article.
PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state.
Iris Mair, Dario Besusso, +7 authors, Richard J Mellanby.
Eur J Immunol, 2018 Nov 30; 49(1). PMID: 30485411    Free PMC article.
The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters.
Monika Walankiewicz, Ewelina Grywalska, +5 authors, Jacek Rolinski.
Mediators Inflamm, 2019 Jan 01; 2018. PMID: 30595667    Free PMC article.
Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy.
David J Zahavi, Louis M Weiner.
Int J Mol Sci, 2019 Jan 10; 20(1). PMID: 30621125    Free PMC article.
A Case of Acute Exacerbation of Chronic Adrenal Insufficiency Due to Ipilimumab Treatment for Advanced Melanoma.
Chihiro Sakaguchi, Seiichi Yano, +11 authors, Yoshihiro Ogawa.
Am J Case Rep, 2019 Jan 27; 20. PMID: 30679413    Free PMC article.
The growing role of precision and personalized medicine for cancer treatment.
Paulina Krzyszczyk, Alison Acevedo, +13 authors, Martin L Yarmush.
Technology (Singap World Sci), 2019 Feb 05; 6(3-4). PMID: 30713991    Free PMC article.
Recent success and limitations of immune checkpoint inhibitors for cancer: a lesson from melanoma.
Margaret Ottaviano, Sabino De Placido, Paolo Antonio Ascierto.
Virchows Arch, 2019 Feb 13; 474(4). PMID: 30747264
Targeting Immune Checkpoints in Lung Cancer: Current Landscape and Future Prospects.
Long Long, Chen Zhao, +3 authors, Honglei Chen.
Clin Drug Investig, 2019 Feb 20; 39(4). PMID: 30778885
Co-inhibitory T cell receptor KLRG1: human cancer expression and efficacy of neutralization in murine cancer models.
Steven A Greenberg, Sek Won Kong, Evan Thompson, Stefano V Gulla.
Oncotarget, 2019 Mar 13; 10(14). PMID: 30858925    Free PMC article.
Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Hongchuan Liu, Lijing Guo, +12 authors, Jinghua Yan.
MAbs, 2019 Mar 21; 11(4). PMID: 30892132    Free PMC article.
Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes.
Peng Sun, Qingyan Jin, +4 authors, Fang Guo.
J Diabetes Res, 2019 Apr 23; 2019. PMID: 31008114    Free PMC article.
Combination of CTLA-4 and PD-1 blockers for treatment of cancer.
Anand Rotte.
J Exp Clin Cancer Res, 2019 Jun 15; 38(1). PMID: 31196207    Free PMC article.
Highly Cited. Review.
Genetic and genomic basis of the mismatch repair system involved in Lynch syndrome.
Kazuo Tamura, Motohide Kaneda, +5 authors, Junko Tatsumi-Miyajima.
Int J Clin Oncol, 2019 Jul 06; 24(9). PMID: 31273487
The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition.
Gilda Varricchi, Stefania Loffredo, +6 authors, Maria Rosaria Galdiero.
Int J Mol Sci, 2019 Aug 16; 20(16). PMID: 31412566    Free PMC article.
Unraveling exhaustion in adaptive and conventional NK cells.
Aimee M Merino, Hansol Kim, Jeffrey S Miller, Frank Cichocki.
J Leukoc Biol, 2020 Jul 30; 108(4). PMID: 32726880    Free PMC article.
CNOT4 enhances the efficacy of anti-PD-1 immunotherapy in a model of non-small cell lung cancer.
Biao Zhang, Song Han, Haitao Ma, Shaomu Chen.
FEBS Open Bio, 2020 Oct 10; 10(12). PMID: 33034149    Free PMC article.
Discovery Strategies to Maximize the Clinical Potential of T-Cell Engaging Antibodies for the Treatment of Solid Tumors.
Vladimir Voynov, Paul J Adam, Andrew E Nixon, Justin M Scheer.
Antibodies (Basel), 2020 Nov 22; 9(4). PMID: 33217946    Free PMC article.
Overcoming Immune Evasion in Melanoma.
Kevinn Eddy, Suzie Chen.
Int J Mol Sci, 2020 Dec 02; 21(23). PMID: 33256089    Free PMC article.
Effect of age and sex on immune checkpoint expression and kinetics in human T cells.
Rosanne D Reitsema, Rebeca Hid Cadena, +6 authors, Peter Heeringa.
Immun Ageing, 2020 Dec 10; 17(1). PMID: 33292359    Free PMC article.
Activating the Antitumor Immune Response in Non-Hodgkin Lymphoma Using Immune Checkpoint Inhibitors.
Maansi Joshi, Stephen M Ansell.
J Immunol Res, 2020 Dec 10; 2020. PMID: 33294467    Free PMC article.
The biomarkers related to immune related adverse events caused by immune checkpoint inhibitors.
Xiao-Hui Jia, Lu-Ying Geng, +7 authors, Hui Guo.
J Exp Clin Cancer Res, 2020 Dec 16; 39(1). PMID: 33317597    Free PMC article.
Regulation of PD-L1 Expression by NF-κB in Cancer.
Fabrizio Antonangeli, Ambra Natalini, +3 authors, Francesca Di Rosa.
Front Immunol, 2020 Dec 17; 11. PMID: 33324403    Free PMC article.
Inhibitory receptor agonists: the future of autoimmune disease therapeutics?
Stephanie Grebinoski, Dario Aa Vignali.
Curr Opin Immunol, 2020 Jul 04; 67. PMID: 32619929    Free PMC article.
Stroke-Induced Modulation of Myeloid-Derived Suppressor Cells (MDSCs) and IL-10-Producing Regulatory Monocytes.
Lennart Achmus, Johanna Ruhnau, +5 authors, Antje Vogelgesang.
Front Neurol, 2020 Dec 18; 11. PMID: 33329318    Free PMC article.
From the T-cell receptor to cancer therapy: an interview with Tak W. Mak.
Tak W Mak.
Cell Death Differ, 2020 Dec 19; 28(1). PMID: 33335286    Free PMC article.
Regulation and Function of the PD-L1 Checkpoint.
Chong Sun, Riccardo Mezzadra, Ton N Schumacher.
Immunity, 2018 Mar 22; 48(3). PMID: 29562194    Free PMC article.
Highly Cited. Review.
Neoadjuvant checkpoint blockade for cancer immunotherapy.
Suzanne L Topalian, Janis M Taube, Drew M Pardoll.
Science, 2020 Feb 01; 367(6477). PMID: 32001626    Free PMC article.
Management of nephrotoxicity of chemotherapy and targeted agents: 2020.
Varsha Chiruvella, Pavan Annamaraju, Achuta K Guddati.
Am J Cancer Res, 2021 Jan 09; 10(12). PMID: 33414992    Free PMC article.
The PD-1:PD-L1 axis in Inflammatory Arthritis.
Mary Canavan, Achilleas Floudas, Douglas J Veale, Ursula Fearon.
BMC Rheumatol, 2021 Jan 12; 5(1). PMID: 33423684    Free PMC article.
Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function.
Juan Huang, Jian Peng, +11 authors, Li Wen.
Cell Mol Immunol, 2021 Jan 13; 18(2). PMID: 33432061    Free PMC article.
Immune checkpoint inhibitor-induced musculoskeletal manifestations.
Foteini Angelopoulou, Dimitrios Bogdanos, +2 authors, Dimitrios Daoussis.
Rheumatol Int, 2020 Aug 04; 41(1). PMID: 32743706
High expression level of interleukin-1β is correlated with poor prognosis and PD-1 expression in patients with lung adenocarcinoma.
X Ding, J Zhang, +5 authors, K Ai.
Clin Transl Oncol, 2020 May 31; 23(1). PMID: 32472456
Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome.
Akinsola Oyelakin, Erich Horeth, +17 authors, Rose-Anne Romano.
Front Immunol, 2021 Jan 26; 11. PMID: 33488608    Free PMC article.
Immune regulation in renal inflammation.
Katrin Neumann, Gisa Tiegs.
Cell Tissue Res, 2021 Jan 27; 385(2). PMID: 33496881    Free PMC article.
Rethinking immune checkpoint blockade: 'Beyond the T cell'.
Xiuting Liu, Graham D Hogg, David G DeNardo.
J Immunother Cancer, 2021 Jan 21; 9(1). PMID: 33468555    Free PMC article.
Immune Checkpoint Molecules-Inherited Variations as Markers for Cancer Risk.
Marta Wagner, Monika Jasek, Lidia Karabon.
Front Immunol, 2021 Feb 02; 11. PMID: 33519815    Free PMC article.
Immune Checkpoint-Related Gene Polymorphisms Are Associated With Primary Immune Thrombocytopenia.
Shuwen Wang, Xiaoyu Zhang, +8 authors, Xiang Hu.
Front Immunol, 2021 Feb 16; 11. PMID: 33584705    Free PMC article.
Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events.
Matin Dokht Ashoori, Kensuke Suzuki, +4 authors, Akio Ohta.
Front Immunol, 2021 Feb 16; 11. PMID: 33584713    Free PMC article.
Immune checkpoint inhibition in COVID-19: risks and benefits.
Parmida Sadat Pezeshki, Nima Rezaei.
Expert Opin Biol Ther, 2021 Feb 06; 21(9). PMID: 33543652    Free PMC article.
Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities.
Kevinn Eddy, Raj Shah, Suzie Chen.
Front Oncol, 2021 Feb 23; 10. PMID: 33614507    Free PMC article.
Immune Checkpoint Inhibitors: Cardiotoxicity in Pre-clinical Models and Clinical Studies.
Shirley Xu, Umesh C Sharma, Cheyanna Tuttle, Saraswati Pokharel.
Front Cardiovasc Med, 2021 Feb 23; 8. PMID: 33614750    Free PMC article.
Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets.
Trixy Fang, Jonatan Alvelid, +3 authors, Ana I Teixeira.
ACS Nano, 2021 Feb 09; 15(2). PMID: 33556239    Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
Immune Profile Analysis in Peripheral Blood and Tumor in Patients with Malignant Melanoma.
Ryuichi Saito, Yu Sawada, Motonobu Nakamura.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33669410    Free PMC article.
CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.
Hadas Lewinsky, Emine G Gunes, +24 authors, Idit Shachar.
JCI Insight, 2021 Jan 20; 6(4). PMID: 33465053    Free PMC article.
Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy.
Rangarirai Makuku, Neda Khalili, +2 authors, Nima Rezaei.
J Immunol Res, 2021 Mar 09; 2021. PMID: 33681388    Free PMC article.
The Efficacy and Safety of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease.
Hui Tang, Jianfeng Zhou, Chunmei Bai.
Front Oncol, 2021 Mar 12; 11. PMID: 33692958    Free PMC article.
Novel PD-L1 mAb HC16 reveals upregulation of PD-L1 in BAC subtype.
Bor-Chyuan Su, Chen-Hung Ting, +4 authors, Jyh-Yih Chen.
Histol Histopathol, 2020 Oct 29; 36(1). PMID: 33112410
Transcriptional and epigenetic regulation of PD-1 expression.
Zengde Chi, Yan Lu, +2 authors, Peiyuan Lu.
Cell Mol Life Sci, 2021 Mar 20; 78(7). PMID: 33738533
An in vivo method for diversifying the functions of therapeutic antibodies.
Ming Tian, Hwei-Ling Cheng, +8 authors, Frederick W Alt.
Proc Natl Acad Sci U S A, 2021 Mar 05; 118(10). PMID: 33658386    Free PMC article.
Renal toxicity of targeted therapies for renal cell carcinoma in patients with normal and impaired kidney function.
Łukasz Mielczarek, Anna Brodziak, +3 authors, Anna M Czarnecka.
Cancer Chemother Pharmacol, 2021 Mar 27; 87(6). PMID: 33768301    Free PMC article.
The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy.
Jongdae Lee, Beatriz Lozano-Ruiz, +3 authors, Jose M González-Navajas.
Front Immunol, 2021 Mar 30; 12. PMID: 33777008    Free PMC article.
Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer.
Pilar Martín, Rafael Blanco-Domínguez, Raquel Sánchez-Díaz.
Cell Mol Immunol, 2020 Nov 26; 18(4). PMID: 33235388    Free PMC article.
Advanced Nanotechnology for Enhancing Immune Checkpoint Blockade Therapy.
Chiara Cremolini, Emanuela Vitale, Raffaella Rastaldo, Claudia Giachino.
Nanomaterials (Basel), 2021 Apr 04; 11(3). PMID: 33800368    Free PMC article.
Thyroid Dysfunction in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors (ICIs): Outcomes in a Multiethnic Urban Cohort.
Angelica D'Aiello, Juan Lin, +5 authors, Balazs Halmos.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33806774    Free PMC article.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison.
Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470    Free PMC article.
A snapshot of the PD-1/PD-L1 pathway.
Chinmoy Ghosh, Gary Luong, Yue Sun.
J Cancer, 2021 Apr 16; 12(9). PMID: 33854633    Free PMC article.
Emerging Role of PD-1 in the Central Nervous System and Brain Diseases.
Junli Zhao, Alexus Roberts, +2 authors, Ru-Rong Ji.
Neurosci Bull, 2021 Apr 21; 37(8). PMID: 33877518    Free PMC article.
Immune Checkpoints in Pediatric Solid Tumors: Targetable Pathways for Advanced Therapeutic Purposes.
Claudia Cocco, Fabio Morandi, Irma Airoldi.
Cells, 2021 May 01; 10(4). PMID: 33920505    Free PMC article.
Immune Checkpoints, Inhibitors and Radionuclides in Prostate Cancer: Promising Combinatorial Therapy Approach.
Mankgopo M Kgatle, Tebatso M G Boshomane, +7 authors, Mike M Sathekge.
Int J Mol Sci, 2021 May 01; 22(8). PMID: 33921181    Free PMC article.
Immune Checkpoint Inhibitors: New Weapons Against Medullary Thyroid Cancer?
Sergio Di Molfetta, Andrea Dotto, +4 authors, Antongiulio Faggiano.
Front Endocrinol (Lausanne), 2021 May 04; 12. PMID: 33935977    Free PMC article.
The Role of Programmed Death-1 in Type 1 Diabetes.
Christopher G Tucker, Alexander J Dwyer, Brian T Fife, Tijana Martinov.
Curr Diab Rep, 2021 May 07; 21(6). PMID: 33956235    Free PMC article.
Immune-related adverse events of checkpoint inhibitors.
Manuel Ramos-Casals, Julie R Brahmer, +7 authors, Maria E Suárez-Almazor.
Nat Rev Dis Primers, 2020 May 10; 6(1). PMID: 32382051
Mesencephalic astrocyte-derived neurotrophic factor is secreted from interferon-γ-activated tumor cells through ER calcium depletion.
Michael Peled, Tali H Bar-Lev, +7 authors, Amir Onn.
PLoS One, 2021 Apr 24; 16(4). PMID: 33891607    Free PMC article.
Soluble immune checkpoint molecules: Serum markers for cancer diagnosis and prognosis.
Rituparna Chakrabarti, Bhavya Kapse, Gayatri Mukherjee.
Cancer Rep (Hoboken), 2020 Jul 29; 2(4). PMID: 32721130    Free PMC article.
Luminal Breast Cancer: Risk of Recurrence and Tumor-Associated Immune Suppression.
Benedetta Pellegrino, Zuzana Hlavata, +5 authors, Cinzia Solinas.
Mol Diagn Ther, 2021 May 12; 25(4). PMID: 33974235    Free PMC article.
Immune Checkpoints, a Novel Class of Therapeutic Targets for Autoimmune Diseases.
Yujia Zhai, Reza Moosavi, Mingnan Chen.
Front Immunol, 2021 May 11; 12. PMID: 33968036    Free PMC article.
Mechanisms and Management of Immune Checkpoint Inhibitor-Related Cardiac Adverse Events.
Hiroshi Kadowaki, Hiroshi Akazawa, Junichi Ishida, Issei Komuro.
JMA J, 2021 May 18; 4(2). PMID: 33997442    Free PMC article.
PD-1/PD-L1 in Cancer: Pathophysiological, Diagnostic and Therapeutic Aspects.
Enrico Munari, Francesca R Mariotti, +9 authors, Lorenzo Moretta.
Int J Mol Sci, 2021 Jun 03; 22(10). PMID: 34066087    Free PMC article.
PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma.
Joshua W D Tobin, Karolina Bednarska, Ashlea Campbell, Colm Keane.
Cells, 2021 Jun 03; 10(5). PMID: 34068762    Free PMC article.
Molecular Mechanisms of PD-1 and PD-L1 Activity on a Pan-Cancer Basis: A Bioinformatic Exploratory Study.
Siddarth Kannan, Geraldine Martina O'Connor, Emyr Yosef Bakker.
Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34067485    Free PMC article.
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Kyoko Oura, Asahiro Morishita, Joji Tani, Tsutomu Masaki.
Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34071550    Free PMC article.
Immune Checkpoint Inhibitor-Associated Pneumonitis in Non-Small Cell Lung Cancer: Current Understanding in Characteristics, Diagnosis, and Management.
Qin Zhang, Liansha Tang, +2 authors, Weimin Li.
Front Immunol, 2021 Jun 15; 12. PMID: 34122422    Free PMC article.
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity.
Jenna L Collier, Sarah A Weiss, +2 authors, Arlene H Sharpe.
Nat Immunol, 2021 Jun 19; 22(7). PMID: 34140679
The Immunology of Hormone Receptor Positive Breast Cancer.
Jonathan Goldberg, Ricardo G Pastorello, +9 authors, Jennifer L Guerriero.
Front Immunol, 2021 Jun 18; 12. PMID: 34135901    Free PMC article.
Dynamic Collaborations for the Development of Immune Checkpoint Blockade Agents.
Arisa Djurian, Tomohiro Makino, +2 authors, Kota Kodama.
J Pers Med, 2021 Jun 03; 11(6). PMID: 34073680    Free PMC article.
Spontaneous and Immune Checkpoint Inhibitor-Induced Autoimmune Diseases: Analysis of Temporal Information by Using the Japanese Adverse Drug Event Report Database.
Keiko Ogawa, Yoshihiro Kozuka, +3 authors, Rumiko Hosoki.
Clin Drug Investig, 2021 Jun 11; 41(7). PMID: 34110613
Rheumatic Immune-Related Adverse Events-A Consequence of Immune Checkpoint Inhibitor Therapy.
Anca Bobircă, Florin Bobircă, +6 authors, Anca Emanuela Mușetescu.
Biology (Basel), 2021 Jul 03; 10(6). PMID: 34203101    Free PMC article.
Neurological Immunotoxicity from Cancer Treatment.
Sarah F Wesley, Aya Haggiagi, Kiran T Thakur, Philip L De Jager.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201529    Free PMC article.
CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness.
Shingo Inaguma, Jerzy Lasota, +11 authors, Hiroshi Ikeda.
J Pathol, 2019 Oct 23; 250(2). PMID: 31639216    Free PMC article.
Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma.
Teizo Asano, Tomokazu Ohishi, +9 authors, Yukinari Kato.
Oncol Rep, 2021 Jun 30; 46(2). PMID: 34184091    Free PMC article.
A phase I study of IMC-001, a PD-L1 blocker, in patients with metastatic or locally advanced solid tumors.
Bhumsuk Keam, Chan-Young Ock, +12 authors, Young Suk Park.
Invest New Drugs, 2021 Jul 17; 39(6). PMID: 34268711
Myocarditis Induced by Immune Checkpoint Inhibitors: Mechanisms and Therapeutic Prospects.
Wenlu Zou, Jie Lu, Yan Hao.
J Inflamm Res, 2021 Jul 17; 14. PMID: 34267536    Free PMC article.
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy.
Bonnie L Russell, Selisha A Sooklal, +2 authors, Monde Ntwasa.
Front Oncol, 2021 Jul 17; 11. PMID: 34268109    Free PMC article.
Detection of Immune Checkpoint Receptors - A Current Challenge in Clinical Flow Cytometry.
Benjamin Shibru, Katharina Fey, +8 authors, Andreas Boldt.
Front Immunol, 2021 Jul 20; 12. PMID: 34276685    Free PMC article.
PD-1 and beyond to Activate T Cells in Cutaneous Squamous Cell Cancers: The Case for 4-1BB and VISTA Antibodies in Combination Therapy.
Quentin Wright, Jazmina L Gonzalez Cruz, James W Wells, Graham R Leggatt.
Cancers (Basel), 2021 Jul 21; 13(13). PMID: 34282763    Free PMC article.
Computational design of a synthetic PD-1 agonist.
Cassie M Bryan, Gabriel J Rocklin, +10 authors, David Baker.
Proc Natl Acad Sci U S A, 2021 Jul 18; 118(29). PMID: 34272285    Free PMC article.
PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective.
HaiXia Li, Chao Zheng, +3 authors, Tao Jin.
Front Cell Neurosci, 2021 Aug 13; 15. PMID: 34381337    Free PMC article.
Post-transcriptional control of T-cell cytokine production: Implications for cancer therapy.
Julian J Freen-van Heeren.
Immunology, 2021 Apr 23; 164(1). PMID: 33884612    Free PMC article.
Role of the PD-1/PD-L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions.
Yan Mi, Jinming Han, Jie Zhu, Tao Jin.
Mol Neurobiol, 2021 Sep 05; 58(12). PMID: 34480337    Free PMC article.
The Role of Oncogenes and Redox Signaling in the Regulation of PD-L1 in Cancer.
Christophe Glorieux, Xiaojun Xia, Peng Huang.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503236    Free PMC article.
Immunotherapy in Gastroesophageal Cancers: Current Evidence and Ongoing Trials.
Jasmine Huynh, Kanishka Patel, +4 authors, Samuel Klempner.
Curr Treat Options Oncol, 2021 Sep 16; 22(11). PMID: 34524553
Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan.
Saori Mizuno-Iijima, Toshiaki Nakashiba, +11 authors, Atsushi Yoshiki.
Mamm Genome, 2021 Sep 18; 33(1). PMID: 34532769    Free PMC article.
Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer.
Yong-Bo Kang, Yue Cai.
World J Gastroenterol, 2021 Sep 21; 27(32). PMID: 34539138    Free PMC article.
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy.
Jinhua Liu, Zichao Chen, +3 authors, Zhen Zhang.
Front Pharmacol, 2021 Sep 21; 12. PMID: 34539412    Free PMC article.
p53 Activation Effect in the Balance of T Regulatory and Effector Cell Subsets in Patients With Thyroid Cancer and Autoimmunity.
Andrea Arena, Antonio Stigliano, +6 authors, Alessandra Fierabracci.
Front Immunol, 2021 Sep 21; 12. PMID: 34539667    Free PMC article.
Development of poly(ADP-ribose) polymerase inhibitor and immunotherapy combinations: progress, pitfalls, and promises.
Melissa M Pham, Natalie Y L Ngoi, +2 authors, Timothy A Yap.
Trends Cancer, 2021 Jun 24; 7(10). PMID: 34158277    Free PMC article.
The Anti-PD-1/PD-L1 Immunotherapy for Gastric Esophageal Cancer: A Systematic Review and Meta-Analysis and Literature Review.
Ke Chen, Xiao Wang, Liu Yang, Zheling Chen.
Cancer Control, 2021 Feb 24; 28. PMID: 33618535    Free PMC article.
Systematic Review.
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH.
Sunil Kumar, Parth Sarthi, +4 authors, Yong-Soo Bae.
Cells, 2021 Sep 29; 10(9). PMID: 34571899    Free PMC article.
Targeting TIGIT for Immunotherapy of Cancer: Update on Clinical Development.
Anand Rotte, Srikumar Sahasranaman, Nageshwar Budha.
Biomedicines, 2021 Sep 29; 9(9). PMID: 34572463    Free PMC article.
Immune Checkpoints in Cancers: From Signaling to the Clinic.
Céline Pisibon, Amira Ouertani, +2 authors, Yann Cheli.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572799    Free PMC article.
Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade.
Yasuhiro Kanda, Taku Okazaki, Tomoya Katakai.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572844    Free PMC article.
Targeting the spectrum of immune checkpoints in prostate cancer.
Laura A Sena, Samuel R Denmeade, Emmanuel S Antonarakis.
Expert Rev Clin Pharmacol, 2021 Jul 16; 14(10). PMID: 34263692    Free PMC article.
Programmed cell death-1 rs11568821 and interleukin-28B rs12979860 polymorphisms in autoimmune hepatitis.
Nikolaos K Gatselis, Kalliopi Azariadis, Aggeliki Lyberopoulou, George N Dalekos.
J Transl Autoimmun, 2021 Oct 12; 4. PMID: 34632357    Free PMC article.
Emerging concepts in PD-1 checkpoint biology.
Kristen E Pauken, James A Torchia, +2 authors, Gordon J Freeman.
Semin Immunol, 2021 May 20; 52. PMID: 34006473    Free PMC article.
PD-1 preferentially inhibits the activation of low-affinity T cells.
Kenji Shimizu, Daisuke Sugiura, +3 authors, Taku Okazaki.
Proc Natl Acad Sci U S A, 2021 Aug 27; 118(35). PMID: 34433672    Free PMC article.
Identification of Novel Modalities Through Bibliometric Analysis for Timely Development of Regulatory Guidance: A Case Study of T Cell Immunity.
Ai Fukaya-Shiba, Kouhei Otsuka, +2 authors, Rika Wakao.
Front Med (Lausanne), 2021 Oct 29; 8. PMID: 34708061    Free PMC article.
Risk factors for immune-related adverse events: what have we learned and what lies ahead?
Xiaoyan Liu, Yuequan Shi, +7 authors, Mengzhao Wang.
Biomark Res, 2021 Nov 05; 9(1). PMID: 34732257    Free PMC article.
Checkpoint Inhibitors in Melanoma Patients with Underlying Autoimmune Disease.
Hilary Dietz, Sophia C Weinmann, April K Salama.
Cancer Manag Res, 2021 Nov 11; 13. PMID: 34754240    Free PMC article.
Gene editing to enhance the efficacy of cancer cell therapies.
Tara Murty, Crystal L Mackall.
Mol Ther, 2021 Oct 22; 29(11). PMID: 34673274    Free PMC article.
New Insights into the Role of PD-1 and Its Ligands in Allergic Disease.
Miguel Angel Galván Morales, Josaphat Miguel Montero-Vargas, Juan Carlos Vizuet-de-Rueda, Luis M Teran.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34769327    Free PMC article.
Biological Bases of Immune-Related Adverse Events and Potential Crosslinks With Immunogenic Effects of Radiation.
Lilia Bardoscia, Nadia Pasinetti, +2 authors, Angela Sardaro.
Front Pharmacol, 2021 Nov 19; 12. PMID: 34790123    Free PMC article.
Unravelling Checkpoint Inhibitor Associated Autoimmune Diabetes: From Bench to Bedside.
Linda Wu, Venessa H M Tsang, +5 authors, Jenny E Gunton.
Front Endocrinol (Lausanne), 2021 Nov 23; 12. PMID: 34803927    Free PMC article.
The immunotherapeutic role of indoleamine 2,3-dioxygenase in head and neck squamous cell carcinoma: A systematic review.
Daniel J Lin, James C K Ng, +4 authors, Andrew L Mellor.
Clin Otolaryngol, 2021 May 31; 46(5). PMID: 34053179    Free PMC article.
Systematic Review.
Study on Horizon Scanning by Citation Network Analysis and Text Mining: A Focus on Drug Development Related to T Cell Immune Response.
Erika Fujii, Takuya Takata, +4 authors, Mayumi Shikano.
Ther Innov Regul Sci, 2021 Nov 24; 56(2). PMID: 34811710    Free PMC article.
The Potential Advantage of Targeting Both PD-L1/PD-L2/PD-1 and IL-10-IL-10R Pathways in Acute Myeloid Leukemia.
Laura Jimbu, Oana Mesaros, +5 authors, Mihnea Zdrenghea.
Pharmaceuticals (Basel), 2021 Nov 28; 14(11). PMID: 34832887    Free PMC article.
Role of PD-L1 in licensing immunoregulatory function of dental pulp mesenchymal stem cells.
Rosanna Di Tinco, Giulia Bertani, +11 authors, Gianluca Carnevale.
Stem Cell Res Ther, 2021 Dec 06; 12(1). PMID: 34863286    Free PMC article.
Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy.
Nicolas Jacquelot, Maryam Ghaedi, +3 authors, Pamela S Ohashi.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885076    Free PMC article.
Immunotherapy of Ovarian Cancer with Particular Emphasis on the PD-1/PDL-1 as Target Points.
Janina Świderska, Mateusz Kozłowski, Sebastian Kwiatkowski, Aneta Cymbaluk-Płoska.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885169    Free PMC article.
The Price of Success: Immune-Related Adverse Events from Immunotherapy in Lung Cancer.
Courtney H Coschi, Rosalyn A Juergens.
Curr Oncol, 2021 Dec 14; 28(6). PMID: 34898551    Free PMC article.
Biomarkers for immunotherapy in genitourinary malignancies.
Susan F Slovin.
Urol Oncol, 2015 Mar 21; 34(4). PMID: 25791754    Free PMC article.
Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis.
Sigrun R Hofmann, Emil Carlsson, +10 authors, Christian M Hedrich.
J Immunol, 2021 Jun 18; 207(1). PMID: 34135066    Free PMC article.
Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy.
Sukanya Raghavan, Nataliya Tovbis-Shifrin, +10 authors, Rene de Waal Malefyt.
Front Immunol, 2021 Dec 17; 12. PMID: 34912335    Free PMC article.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial.
Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg.
Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy.
Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern.
Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146    Free PMC article.
Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.
Markus P Kummer, Christina Ising, +11 authors, Michael T Heneka.
EMBO J, 2021 Nov 27; 40(24). PMID: 34825707    Free PMC article.
An Update on Immune Based Therapies in Acute Myeloid Leukemia: 2021 and Beyond!
Fadi Haddad, Naval Daver.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972969
Renal Toxicity.
Maen Abdelrahim, Ala Abudayyeh.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972976
pH Low Insertion Peptide-Modified Programmed Cell Death-Ligand 1 Potently Suppresses T-Cell Activation Under Acidic Condition.
Ying Sun, Linhan Hu, +11 authors, Guojiang Chen.
Front Immunol, 2022 Jan 11; 12. PMID: 35003115    Free PMC article.
Metabolic Implications of Immune Checkpoint Proteins in Cancer.
Elizabeth R Stirling, Steven M Bronson, +3 authors, David R Soto-Pantoja.
Cells, 2022 Jan 12; 11(1). PMID: 35011741    Free PMC article.
T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation.
Amalie Kai Bentzen, Sine Reker Hadrup.
Immunooncol Technol, 2019 Sep 01; 2. PMID: 35036898    Free PMC article.
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade.
Golnaz Morad, Beth A Helmink, Padmanee Sharma, Jennifer A Wargo.
Cell, 2021 Oct 09; 184(21). PMID: 34624224    Free PMC article.
Transplantation of IL-1β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats.
Shifeng Pan, Xuan Dong, +4 authors, Hua Xing.
Exp Ther Med, 2022 Jan 25; 23(2). PMID: 35069820    Free PMC article.
Regulation of activated T cell survival in rheumatic autoimmune diseases.
Florencia Rosetti, Iris K Madera-Salcedo, Noé Rodríguez-Rodríguez, José C Crispín.
Nat Rev Rheumatol, 2022 Jan 26; 18(4). PMID: 35075294
Immune-checkpoint inhibitors: long-term implications of toxicity.
Douglas B Johnson, Caroline A Nebhan, Javid J Moslehi, Justin M Balko.
Nat Rev Clin Oncol, 2022 Jan 28; 19(4). PMID: 35082367    Free PMC article.
Vitamin D can reduce severity in COVID-19 through regulation of PD-L1.
Hatice Aygun.
Naunyn Schmiedebergs Arch Pharmacol, 2022 Feb 01; 395(4). PMID: 35099571    Free PMC article.
A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy.
Jin Bian, Yan Niu, +2 authors, Ning Ma.
Appl Bionics Biomech, 2022 Feb 08; 2022. PMID: 35126664    Free PMC article.
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity.
Daisuke Sugiura, Il-Mi Okazaki, +6 authors, Taku Okazaki.
Nat Immunol, 2022 Feb 12; 23(3). PMID: 35145298
Anti-Programmed Death Ligand-1 Induced Acute Vision Loss in a Patient With Cancer-Associated Retinopathy.
Muhammad Z Chauhan, Hana A Mansour, Maroof K Zafar, Sami H Uwaydat.
Cureus, 2022 Feb 12; 14(1). PMID: 35145825    Free PMC article.
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1.
Yuwei Hao, Matthew C Cook.
Front Immunol, 2022 Feb 15; 12. PMID: 35154081    Free PMC article.
Epigenetic Modification of PD-1/PD-L1-Mediated Cancer Immunotherapy against Melanoma.
Hikaru Nanamori, Yu Sawada.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163049    Free PMC article.
Immunogenetics of Lupus Erythematosus.
Begüm Ünlü, Ümit Türsen, +2 authors, Fateme Rajabi.
Adv Exp Med Biol, 2022 Mar 15; 1367. PMID: 35286698
CMTM6 as a master regulator of PD-L1.
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani.
Cancer Immunol Immunother, 2022 Mar 17;. PMID: 35294592
Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors.
Xin Du, Phillip K Darcy, Florian Wiede, Tony Tiganis.
Mol Cell Biol, 2022 Jan 19; 42(3). PMID: 35041491    Free PMC article.
Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy.
Jii Bum Lee, Hye Ryun Kim, Sang-Jun Ha.
Immune Netw, 2022 Mar 17; 22(1). PMID: 35291660    Free PMC article.
Checkpoint Inhibitors and Induction of Celiac Disease-like Condition.
Aaron Lerner, Carina Benzvi.
Biomedicines, 2022 Mar 26; 10(3). PMID: 35327411    Free PMC article.
HLA-G and Other Immune Checkpoint Molecules as Targets for Novel Combined Immunotherapies.
Fabio Morandi, Irma Airoldi.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328349    Free PMC article.
The spectrum of renal diseases with lupus-like features: a single-center study.
Maliha Ahmed, Tanzy Love, +4 authors, Hae Yoon Grace Choung.
Ren Fail, 2022 Apr 01; 44(1). PMID: 35357272    Free PMC article.
PD-1/PD-L1 Inhibitors in Patients With Preexisting Autoimmune Diseases.
Ke Zhang, Xiangyi Kong, +3 authors, Lixue Xuan.
Front Pharmacol, 2022 Apr 05; 13. PMID: 35370736    Free PMC article.
Effects of PD-1 Signaling on Immunometabolic Reprogramming.
Vassiliki A Boussiotis, Nikolaos Patsoukis.
Immunometabolism, 2022 Apr 05; 4(2). PMID: 35371563    Free PMC article.
Immune Checkpoint Inhibitor Nephrotoxicity: Update 2020.
Shruti Gupta, Frank B Cortazar, Leonardo V Riella, David E Leaf.
Kidney360, 2020 Jan 14; 1(2). PMID: 35372904    Free PMC article.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration.
Wenji Piao, Lushen Li, +12 authors, Jonathan S Bromberg.
Nat Commun, 2022 Apr 23; 13(1). PMID: 35449134    Free PMC article.
A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors.
Justin B Hackett, James E Glassbrook, +7 authors, Heather M Gibson.
Oncoimmunology, 2022 Apr 29; 11(1). PMID: 35481286    Free PMC article.
Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues.
Christopher M Bailey, Yan Liu, +5 authors, Yin Wang.
J Clin Invest, 2022 Mar 04; 132(9). PMID: 35239514    Free PMC article.
Melanoma: An immunotherapy journey from bench to bedside.
Vishal Navani, Moira C Graves, +4 authors, Nikola A Bowden.
Cancer Treat Res, 2022 May 14; 183. PMID: 35551656
Endothelial Cells Activated by Extracellular Histones Promote Foxp3+ Suppressive Treg Cells In Vitro.
Marine Arnaud, Jordane Demonchy, +6 authors, Lara Zafrani.
Int J Mol Sci, 2022 May 15; 23(9). PMID: 35562918    Free PMC article.
High-throughput virtual screening of small-molecule inhibitors targeting immune cell checkpoints to discover new immunotherapeutics for human diseases.
Satyendra Singh, Ketan Kumar, +3 authors, Vijay Kumar Prajapati.
Mol Divers, 2022 May 29;. PMID: 35633442
Challenging Dermatologic Considerations Associated with Immune Checkpoint Inhibitors.
Benjamin C Park, Seungyeon Jung, +2 authors, Douglas B Johnson.
Am J Clin Dermatol, 2022 Jun 17;. PMID: 35708849