Journal Article
. 2000 Feb; 6(2):189-95.
doi: 10.1038/72294.

The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

X Xing 1 S C Wang  W Xia  Y Zou  R Shao  K Y Kwong  Z Yu  S Zhang  S Miller  L Huang  M C Hung  
Affiliations
  • PMID: 10655108
  •     45 citations

Abstract

Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER-2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu-overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

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