Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

S Read ¹, V Malmström , F Powrie

Affiliations

¹ Oxford University, Nuffield Department of Surgery, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

PMID: 10899916
46 References
658 citations

Abstract

It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both self- and intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same phenotype (CD25(+)CD45RB(low)CD4(+)) as those that control autoimmunity. Previous studies have failed to identify how CD25(+) Treg cells function in vivo. Our studies reveal that the immune-suppressive function of these cells in vivo is dependent on signaling via the negative regulator of T cell activation cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), as well as secretion of the immune-suppressive cytokine transforming growth factor beta. Strikingly, constitutive expression of CTLA-4 among CD4(+) cells was restricted primarily to Treg cells, suggesting that CTLA-4 expression by these cells is involved in their immune-suppressive function. These findings raise the possibility that Treg cell function contributes to the immune suppression characteristic of CTLA-4 signaling. Identification of costimulatory molecules involved in the function of Treg cells may facilitate further characterization of these cells and development of new therapeutic strategies for the treatment of inflammatory diseases.

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TGF-beta: how tolerant can it be? Sharon M Wahl, Wanjun Chen. Immunol Res, 2004 Jan 10; 28(3). PMID: 14713712 Review.
Antibody-induced transplantation tolerance: the role of dominant regulation. Luis Graca, Alain Le Moine, Stephen P Cobbold, Herman Waldmann. Immunol Res, 2004 Jan 10; 28(3). PMID: 14713713 Review.
Oral tolerance. Henry Yim Wu, Howard L Weiner. Immunol Res, 2004 Jan 10; 28(3). PMID: 14713719 Review.
A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses. Zoltán Fehérvári, Shimon Sakaguchi. Arthritis Res Ther, 2004 Feb 26; 6(1). PMID: 14979928 Free PMC article.
The concept of space and competition in immune regulation. Brigitta Stockinger, Thomas Barthlott, George Kassiotis. Immunology, 2004 Mar 11; 111(3). PMID: 15009422 Free PMC article. Review.
Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen. Masako Kohyama, Daisuke Sugahara, +3 authors, Nobumichi Hozumi. less Proc Natl Acad Sci U S A, 2004 Mar 12; 101(12). PMID: 15014176 Free PMC article.
CD4+ CD25+ Treg: divide and rule? Lucy S K Walker. Immunology, 2004 Mar 19; 111(2). PMID: 15027897 Free PMC article. Review.
Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases. Monika C Brunner-Weinzierl, Holger Hoff, Gerd-R Burmester. Arthritis Res Ther, 2004 Apr 03; 6(2). PMID: 15059264 Free PMC article. Review.
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. Vissia Viglietta, Clare Baecher-Allan, Howard L Weiner, David A Hafler. J Exp Med, 2004 Apr 07; 199(7). PMID: 15067033 Free PMC article. Highly Cited.
Maintenance of remission in Crohn's disease: current and emerging therapeutic options. Matthew J Brookes, Jonathon R B Green. Drugs, 2004 May 14; 64(10). PMID: 15139787 Review.
Differential expression of CTLA-4 among T cell subsets. C B Jago, J Yates, +2 authors, N Olsen Saraiva Câmara, R I Lechler, G Lombardi. less Clin Exp Immunol, 2004 May 19; 136(3). PMID: 15147348 Free PMC article.
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. Mübeccel Akdis, Johan Verhagen, +12 authors, Cezmi A Akdis. less J Exp Med, 2004 Jun 03; 199(11). PMID: 15173208 Free PMC article. Highly Cited.
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. Qizhi Tang, Kammi J Henriksen, +7 authors, Jeffrey A Bluestone. less J Exp Med, 2004 Jun 09; 199(11). PMID: 15184499 Free PMC article. Highly Cited.
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. Ann E Herman, Gordon J Freeman, Diane Mathis, Christophe Benoist. J Exp Med, 2004 Jun 09; 199(11). PMID: 15184501 Free PMC article. Highly Cited.
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes. Catrin M McGregor, Stephen P Schoenberger, E Allison Green. Proc Natl Acad Sci U S A, 2004 Jun 12; 101(25). PMID: 15192149 Free PMC article.
Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. Malin R Karlsson, Jarle Rugtveit, Per Brandtzaeg. J Exp Med, 2004 Jun 16; 199(12). PMID: 15197226 Free PMC article.
Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. Mark P Eggena, Lucy S K Walker, +3 authors, Abul K Abbas. less J Exp Med, 2004 Jun 24; 199(12). PMID: 15210748 Free PMC article.
CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Duojia Cao, Ronald van Vollenhoven, +2 authors, Lars Klareskog, Christina Trollmo, Vivianne Malmström. less Arthritis Res Ther, 2004 Jul 01; 6(4). PMID: 15225369 Free PMC article.
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. Kyra Oswald-Richter, Stacy M Grill, +4 authors, Derya Unutmaz. less PLoS Biol, 2004 Jul 15; 2(7). PMID: 15252446 Free PMC article. Highly Cited.
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. Michael R Ehrenstein, Jamie G Evans, +4 authors, Claudia Mauri. less J Exp Med, 2004 Jul 29; 200(3). PMID: 15280421 Free PMC article. Highly Cited.
Suppressor T cells in human diseases. Clare Baecher-Allan, David A Hafler. J Exp Med, 2004 Jul 29; 200(3). PMID: 15280423 Free PMC article.
Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells. Helene C Dujardin, Odile Burlen-Defranoux, +3 authors, Antonio Bandeira. less Proc Natl Acad Sci U S A, 2004 Sep 29; 101(40). PMID: 15452347 Free PMC article.
CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Taeko Dohi, Kohtaro Fujihashi, +4 authors, Jerry R McGhee. less Am J Pathol, 2004 Oct 07; 165(4). PMID: 15466391 Free PMC article.
CD4+ Tregs and immune control. Zoltán Fehérvari, Shimon Sakaguchi. J Clin Invest, 2004 Nov 03; 114(9). PMID: 15520849 Free PMC article. Highly Cited. Review.
Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody. Dean T Nardelli, Matthew A Burchill, +3 authors, Ronald F Schell. less Clin Diagn Lab Immunol, 2004 Nov 13; 11(6). PMID: 15539509 Free PMC article.
IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. Anne O'Garra, Pedro L Vieira, Paulo Vieira, Anne E Goldfeld. J Clin Invest, 2004 Nov 17; 114(10). PMID: 15545984 Free PMC article. Highly Cited. Review.
Tregs and allergic disease. Douglas S Robinson, Mark Larché, Stephen R Durham. J Clin Invest, 2004 Nov 17; 114(10). PMID: 15545986 Free PMC article. Review.
Characterization of T-regulatory cells, induced by immature dendritic cells, which inhibit enteroantigen-reactive colitis-inducing T-cell responses in vitro and in vivo. Monika Gad, Nanna N Kristensen, Evelyn Kury, Mogens H Claesson. Immunology, 2004 Nov 24; 113(4). PMID: 15554928 Free PMC article.
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. Hyung W Lim, Peter Hillsamer, Chang H Kim. J Clin Invest, 2004 Dec 04; 114(11). PMID: 15578096 Free PMC article.
Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. Hideaki Sugiyama, Rolland Gyulai, +5 authors, Kevin D Cooper. less J Immunol, 2004 Dec 22; 174(1). PMID: 15611238 Free PMC article. Highly Cited.
Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. Shuang Liang, Pascale Alard, +3 authors, Michele M Kosiewicz. less J Exp Med, 2005 Jan 05; 201(1). PMID: 15630140 Free PMC article.
Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGepsilon26 mice leading to the prevention of colitis. C Veltkamp, R B Sartor, +6 authors, W Stremmel. less Gut, 2005 Jan 14; 54(2). PMID: 15647183 Free PMC article.
Regulatory cells and the control of respiratory infection. Peter McGuirk, Sarah C Higgins, Kingston H G Mills. Curr Allergy Asthma Rep, 2005 Jan 22; 5(1). PMID: 15659263 Review.
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. Roland Grenningloh, Bok Yun Kang, I-Cheng Ho. J Exp Med, 2005 Feb 25; 201(4). PMID: 15728239 Free PMC article.
Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases. Sharon M Wahl, Wanjun Chen. Arthritis Res Ther, 2005 Mar 04; 7(2). PMID: 15743491 Free PMC article. Review.
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. Linda Fahlén, Simon Read, +4 authors, Fiona Powrie. less J Exp Med, 2005 Mar 09; 201(5). PMID: 15753207 Free PMC article. Highly Cited.
Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Santiago Zelenay, Thiago Lopes-Carvalho, +3 authors, Jocelyne Demengeot. less Proc Natl Acad Sci U S A, 2005 Mar 09; 102(11). PMID: 15753306 Free PMC article.
A role for alphabeta T cells in the resistant phase of the Brown Norway rat model of vasculitis. C S Vinen, D R Turner, D B G Oliveira. Clin Exp Immunol, 2005 Mar 15; 140(1). PMID: 15762872 Free PMC article.
Down-regulation of epithelial IL-8 responses in Helicobacter pylori-infected duodenal ulcer patients depends on host factors, rather than bacterial factors. E Strömberg, A Edebo, +4 authors, C Lindholm. less Clin Exp Immunol, 2005 Mar 15; 140(1). PMID: 15762883 Free PMC article.
CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. M Möttönen, J Heikkinen, +3 authors, L Mustonen, P Isomäki, R Luukkainen, O Lassila. less Clin Exp Immunol, 2005 Apr 06; 140(2). PMID: 15807863 Free PMC article.
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. Shannon M Pop, Carmen P Wong, +2 authors, Donna A Culton, Stephen H Clarke, Roland Tisch. less J Exp Med, 2005 Apr 20; 201(8). PMID: 15837817 Free PMC article.
Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease. Yoshihisa Yamano, Norihiro Takenouchi, +5 authors, Steven Jacobson. less J Clin Invest, 2005 May 03; 115(5). PMID: 15864353 Free PMC article.
Multiple costimulatory modalities enhance CTL avidity. James W Hodge, Mala Chakraborty, +2 authors, Chie Kudo-Saito, Charlie T Garnett, Jeffrey Schlom. less J Immunol, 2005 May 10; 174(10). PMID: 15879092 Free PMC article.
Regulatory T cells in rheumatoid arthritis. Jan Leipe, Alla Skapenko, Peter E Lipsky, Hendrik Schulze-Koops. Arthritis Res Ther, 2005 May 19; 7(3). PMID: 15899057 Free PMC article. Review.
Oral tolerance in the absence of naturally occurring Tregs. Daniel Mucida, Nino Kutchukhidze, +3 authors, Maria A Curotto de Lafaille. less J Clin Invest, 2005 Jun 07; 115(7). PMID: 15937545 Free PMC article. Highly Cited.
CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection. Dean T Nardelli, Joseph P Cloute, +4 authors, Ronald F Schell. less Clin Diagn Lab Immunol, 2005 Jun 09; 12(6). PMID: 15939755 Free PMC article.
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. Claudia R Ruprecht, Marco Gattorno, +4 authors, Federica Sallusto. less J Exp Med, 2005 Jun 09; 201(11). PMID: 15939793 Free PMC article. Highly Cited.
Activated CD4+ CD25+ T cells suppress antigen-specific CD4+ and CD8+ T cells but induce a suppressive phenotype only in CD4+ T cells. Detlef Dieckmann, Heidi Plöttner, Stefanie Dotterweich, Gerold Schuler. Immunology, 2005 Jun 11; 115(3). PMID: 15946248 Free PMC article.
The role of mucosal T lymphocytes in regulating intestinal inflammation. Holm H Uhlig, Fiona Powrie. Springer Semin Immunopathol, 2005 Jun 17; 27(2). PMID: 15959782 Review.
Role of helminths in regulating mucosal inflammation. Joel V Weinstock, Robert W Summers, David E Elliott. Springer Semin Immunopathol, 2005 Jun 17; 27(2). PMID: 15959781 Review.
Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae. Victoria Gillan, Eileen Devaney. Infect Immun, 2005 Jun 24; 73(7). PMID: 15972491 Free PMC article.
A peripheral circulating compartment of natural naive CD4 Tregs. Danila Valmori, Andrea Merlo, +2 authors, Maha Ayyoub. less J Clin Invest, 2005 Jul 12; 115(7). PMID: 16007258 Free PMC article. Highly Cited.
Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells. Badiga Venkata Aruna, Michael Sela, Edna Mozes. Proc Natl Acad Sci U S A, 2005 Jul 15; 102(29). PMID: 16014414 Free PMC article.
FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease. J Kelsen, J Agnholt, +3 authors, H J Hoffmann, J L Rømer, C L Hvas, J F Dahlerup. less Clin Exp Immunol, 2005 Jul 28; 141(3). PMID: 16045746 Free PMC article.
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. Niklas Beyersdorf, Stefanie Gaupp, +7 authors, Ralf Gold. less J Exp Med, 2005 Aug 03; 202(3). PMID: 16061730 Free PMC article.
The role of the FOXP3 transcription factor in the immune regulation of allergic asthma. Carsten B Schmidt-Weber, Kurt Blaser. Curr Allergy Asthma Rep, 2005 Aug 11; 5(5). PMID: 16091206 Review.
Function of tumor necrosis factor receptor family members on regulatory T-cells. Robert H Arch. Immunol Res, 2005 Aug 18; 32(1-3). PMID: 16106056 Review.
Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor. Iris Bellinghausen, Bettina König, +2 authors, Ingo Böttcher, Jürgen Knop, Joachim Saloga. less Immunology, 2005 Aug 20; 116(1). PMID: 16108822 Free PMC article.
Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice. K Inagaki-Ohara, A Sasaki, +7 authors, A Yoshimura. less Gut, 2005 Aug 27; 55(2). PMID: 16120757 Free PMC article.
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. Helga Schneider, Elke Valk, +2 authors, Silvy da Rocha Dias, Bin Wei, Christopher E Rudd. less Proc Natl Acad Sci U S A, 2005 Aug 30; 102(36). PMID: 16126897 Free PMC article.
CD4+ regulatory cells as a potential immunotherapy. Zoltán Fehérvari, Shimon Sakaguchi. Philos Trans R Soc Lond B Biol Sci, 2005 Sep 09; 360(1461). PMID: 16147529 Free PMC article. Review.
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Masayuki Sho, Koji Kishimoto, +8 authors, David M Rothstein. less Proc Natl Acad Sci U S A, 2005 Sep 10; 102(37). PMID: 16150717 Free PMC article.
Co-stimulatory blockade as therapy for rheumatoid arthritis. Sarah L Mackie, Edward M Vital, Frederique Ponchel, Paul Emery. Curr Rheumatol Rep, 2005 Sep 22; 7(5). PMID: 16174492 Review.
Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44. Mihail Firan, Sohita Dhillon, Pila Estess, Mark H Siegelman. Blood, 2005 Sep 24; 107(2). PMID: 16179372 Free PMC article.
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. Kuibeom Ko, Sayuri Yamazaki, +7 authors, Shimon Sakaguchi. less J Exp Med, 2005 Sep 28; 202(7). PMID: 16186187 Free PMC article. Highly Cited.
Essential role for CD103 in the T cell-mediated regulation of experimental colitis. Oliver Annacker, Janine L Coombes, +6 authors, Fiona Powrie. less J Exp Med, 2005 Oct 12; 202(8). PMID: 16216886 Free PMC article. Highly Cited.
Biologic therapy for inflammatory bowel disease. Sandro Ardizzone, Gabriele Bianchi Porro. Drugs, 2005 Nov 04; 65(16). PMID: 16266194 Review.
Modulation of surgical fibrosis by microbial zwitterionic polysaccharides. Begonia Ruiz-Perez, Doo R Chung, +5 authors, Arthur O Tzianabos. less Proc Natl Acad Sci U S A, 2005 Nov 09; 102(46). PMID: 16275921 Free PMC article.
Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes. Roberto Mallone, Gerald T Nepom. Am J Ther, 2005 Nov 11; 12(6). PMID: 16280647 Free PMC article. Review.
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ajay V Maker, Giao Q Phan, +11 authors, Steven A Rosenberg. less Ann Surg Oncol, 2005 Nov 12; 12(12). PMID: 16283570 Free PMC article. Highly Cited.
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. Ajay V Maker, Peter Attia, Steven A Rosenberg. J Immunol, 2005 Nov 23; 175(11). PMID: 16301685 Free PMC article.
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Qizhi Tang, Jason Y Adams, +7 authors, Jeffrey A Bluestone. less Nat Immunol, 2005 Nov 29; 7(1). PMID: 16311599 Free PMC article. Highly Cited.
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. Ian P Lewkowich, Nancy S Herman, +8 authors, Marsha Wills-Karp. less J Exp Med, 2005 Nov 30; 202(11). PMID: 16314437 Free PMC article. Highly Cited.
Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity. Dirk Homann, Wolfgang Dummer, +4 authors, Matthias G von Herrath. less J Virol, 2005 Dec 15; 80(1). PMID: 16352552 Free PMC article.
Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells. Elena Gonzalez-Rey, Alejo Chorny, +2 authors, Amelia Fernandez-Martin, Doina Ganea, Mario Delgado. less Blood, 2006 Jan 07; 107(9). PMID: 16397128 Free PMC article.
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Zhi-Zhang Yang, Anne J Novak, +2 authors, Mary J Stenson, Thomas E Witzig, Stephen M Ansell. less Blood, 2006 Jan 13; 107(9). PMID: 16403912 Free PMC article. Highly Cited.
Involvement of 4-1BB (CD137)-4-1BBligand interaction in the modulation of CD4 T cell-mediated inflammatory colitis. P Maerten, B S Kwon, +9 authors, J L Ceuppens. less Clin Exp Immunol, 2006 Jan 18; 143(2). PMID: 16412046 Free PMC article.
Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4(+) CD25(+) T cells of patients with inflammatory bowel disease. Maho Ikeda, Fuminao Takeshima, +6 authors, Shigeru Kohno. less Dig Dis Sci, 2006 Jan 18; 51(1). PMID: 16416233
Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response. Alejo Chorny, Elena Gonzalez-Rey, +2 authors, Amelia Fernandez-Martin, Doina Ganea, Mario Delgado. less Blood, 2006 Jan 19; 107(9). PMID: 16418327 Free PMC article.
Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Jyh-Hong Lee, Li-Chieh Wang, +3 authors, Bor-Luen Chiang. less Immunology, 2006 Jan 21; 117(2). PMID: 16423064 Free PMC article.
The immune paradox of sarcoidosis and regulatory T cells. Makoto Miyara, Zahir Amoura, +9 authors, Guy Gorochov. less J Exp Med, 2006 Jan 25; 203(2). PMID: 16432251 Free PMC article. Highly Cited.
Selective roles and dysregulation of interleukin-10 in allergic disease. Judith A Woodfolk. Curr Allergy Asthma Rep, 2006 Feb 16; 6(1). PMID: 16476193 Review.
Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Alison Taylor, Johan Verhagen, +2 authors, Kurt Blaser, Mübeccel Akdis, Cezmi A Akdis. less Immunology, 2006 Mar 25; 117(4). PMID: 16556256 Free PMC article. Highly Cited. Review.
Total colectomy improves altered distribution of regulatory T cells in patients with ulcerative colitis. Makoto Furihata, Tokihiko Sawada, +5 authors, Keiichi Kubota. less World J Surg, 2006 Mar 29; 30(4). PMID: 16568230
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. Ichiko Kinjyo, Hiromasa Inoue, +8 authors, Akihiko Yoshimura. less J Exp Med, 2006 Apr 12; 203(4). PMID: 16606674 Free PMC article.
T regulatory cell suppression of colitis: the role of TGF-beta. R Duchmann, M Zeitz. Gut, 2006 Apr 13; 55(5). PMID: 16609133 Free PMC article.
An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis. Makoto Takahashi, Kazuhiko Nakamura, +7 authors, Hajime Nawata. less Dig Dis Sci, 2006 Apr 15; 51(4). PMID: 16614988
Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels. F Bolacchi, A Sinistro, +6 authors, A Bergamini. less Clin Exp Immunol, 2006 Apr 26; 144(2). PMID: 16634790 Free PMC article.
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. Kimberly E Beck, Joseph A Blansfield, +12 authors, James C Yang. less J Clin Oncol, 2006 May 20; 24(15). PMID: 16710025 Free PMC article. Highly Cited.
CD4+ CD25+ regulatory T cells modulate the T-cell and antibody responses in helicobacter-infected BALB/c mice. Maria Kaparakis, Karen L Laurie, +5 authors, Richard A Strugnell. less Infect Immun, 2006 May 23; 74(6). PMID: 16714584 Free PMC article.
Checkpoint blockade in cancer immunotherapy. Alan J Korman, Karl S Peggs, James P Allison. Adv Immunol, 2006 May 30; 90. PMID: 16730267 Free PMC article. Highly Cited. Review.
The role of CD4 T cells in the pathogenesis of murine AIDS. Wen Li, William R Green. J Virol, 2006 May 30; 80(12). PMID: 16731917 Free PMC article.
Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma. Machteld M Tiemessen, Tracey J Mitchell, +3 authors, Susan John. less J Invest Dermatol, 2006 Jun 03; 126(10). PMID: 16741512 Free PMC article.
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression. Cecilia Oderup, Lukas Cederbom, +2 authors, Anna Makowska, Corrado M Cilio, Fredrik Ivars. less Immunology, 2006 Jun 15; 118(2). PMID: 16771859 Free PMC article.
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. Sergio A Quezada, Karl S Peggs, Michael A Curran, James P Allison. J Clin Invest, 2006 Jun 17; 116(7). PMID: 16778987 Free PMC article. Highly Cited.
The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children. C-O Jonson, M Hedman, +5 authors, ABIS Study Group. less Clin Exp Immunol, 2006 Jun 24; 145(1). PMID: 16792673 Free PMC article.
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. Ajay V Maker, James C Yang, +11 authors, Steven A Rosenberg. less J Immunother, 2006 Jun 27; 29(4). PMID: 16799341 Free PMC article.
Signatures of human regulatory T cells: an encounter with old friends and new players. Susanne Pfoertner, Andreas Jeron, +8 authors, Robert Geffers. less Genome Biol, 2006 Jul 14; 7(7). PMID: 16836768 Free PMC article.
Regulatory T cells in experimental autoimmune disease. Elisabeth Suri-Payer, Benedikt Fritzsching. Springer Semin Immunopathol, 2006 Jul 14; 28(1). PMID: 16838180 Review.
Costimulation couture: a designer approach to regulating autoimmunity. Mohammed Javeed Ansari, Mohamed H Sayegh. J Clin Invest, 2006 Aug 04; 116(8). PMID: 16886054 Free PMC article.
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. Brian T Fife, Matthew D Griffin, +2 authors, Abul K Abbas, Richard M Locksley, Jeffrey A Bluestone. less J Clin Invest, 2006 Aug 04; 116(8). PMID: 16886063 Free PMC article.
Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy. Kirsty S Nicolson, David C Wraith. Inflamm Allergy Drug Targets, 2006 Aug 22; 5(3). PMID: 16918477 Free PMC article. Review.
Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule. Henri Braat, Peter McGuirk, +5 authors, Kingston H G Mills. less Gut, 2006 Sep 06; 56(3). PMID: 16952913 Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer. R Houston Thompson, James P Allison, Eugene D Kwon. Urol Oncol, 2006 Sep 12; 24(5). PMID: 16962497 Free PMC article. Review.
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. Simon Read, Rebecca Greenwald, +5 authors, Fiona Powrie. less J Immunol, 2006 Sep 20; 177(7). PMID: 16982872 Free PMC article. Highly Cited.
Cancer immunosuppression and autoimmune disease: beyond immunosuppressive networks for tumour immunity. Ryungsa Kim, Manabu Emi, Kazuaki Tanabe. Immunology, 2006 Sep 29; 119(2). PMID: 17005005 Free PMC article. Review.
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection. John J Zaunders, Susanna Ip, +15 authors, Anthony D Kelleher. less J Virol, 2006 Sep 29; 80(20). PMID: 17005693 Free PMC article.
Interleukin-23 drives innate and T cell-mediated intestinal inflammation. Sophie Hue, Philip Ahern, +5 authors, Kevin J Maloy. less J Exp Med, 2006 Oct 13; 203(11). PMID: 17030949 Free PMC article. Highly Cited.
Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities. Masahisa Jinushi, Tetsuo Takehara, +6 authors, Norio Hayashi. less Immunology, 2006 Oct 21; 120(1). PMID: 17052247 Free PMC article.
Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. Holm H Uhlig, Janine Coombes, +7 authors, Fiona Powrie. less J Immunol, 2006 Oct 24; 177(9). PMID: 17056509 Free PMC article. Highly Cited.
Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells. Deborah H Strickland, Philip A Stumbles, +5 authors, Patrick G Holt. less J Exp Med, 2006 Nov 08; 203(12). PMID: 17088431 Free PMC article.
CD8 blockade promotes the expansion of antigen-specific CD4+ FOXP3+ regulatory T cells in vivo. Z Wang, J D Davies. Int Immunopharmacol, 2006 Dec 21; 7(2). PMID: 17178393 Free PMC article.
CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. Sarah L Clarke, Gareth J Betts, +8 authors, Andrew J Godkin. less PLoS One, 2007 Jan 06; 1. PMID: 17205133 Free PMC article.
The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. Michel H Maillard, Vinicius Cotta-de-Almeida, +5 authors, Scott B Snapper. less J Exp Med, 2007 Feb 14; 204(2). PMID: 17296786 Free PMC article.
CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis. Catherine Q Nie, Nicholas J Bernard, Louis Schofield, Diana S Hansen. Infect Immun, 2007 Feb 28; 75(5). PMID: 17325053 Free PMC article.
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. B Afzali, G Lombardi, R I Lechler, G M Lord. Clin Exp Immunol, 2007 Mar 03; 148(1). PMID: 17328715 Free PMC article. Highly Cited. Review.
The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma. J-H Lee, H-H Yu, +3 authors, L-C Wang, Y-H Yang, Y-T Lin, B-L Chiang. less Clin Exp Immunol, 2007 Mar 14; 148(1). PMID: 17349011 Free PMC article.
Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients. Khoon Lin Ling, Sarah E Pratap, +9 authors, Vincenzo Cerundolo. less Cancer Immun, 2007 Mar 29; 7. PMID: 17388261 Free PMC article.
Demonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis. Yoko Yokoyama, Ken Fukunaga, +9 authors, Takayuki Matsumoto. less Dig Dis Sci, 2007 Apr 04; 52(10). PMID: 17404876
An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. David C Thomas, Richard J Mellanby, Jenny M Phillips, Anne Cooke. Immunology, 2007 Apr 18; 121(4). PMID: 17437531 Free PMC article.
Regulatory cells and immunosuppressive cytokines: parasite-derived factors induce immune polarization. Ali Ouaissi. J Biomed Biotechnol, 2007 Jun 29; 2007(4). PMID: 17597838 Free PMC article.
Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection. Ellen Marks, Martina Verolin, Anneli Stensson, Nils Lycke. Infect Immun, 2007 Jul 20; 75(9). PMID: 17635872 Free PMC article.
CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion. Anders E Pedersen, Franca Ronchese. J Immune Based Ther Vaccines, 2007 Jul 31; 5. PMID: 17662155 Free PMC article.
Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice. L-Y Khil, H-S Jun, +4 authors, H Kwon, J K Yoo, S Kim, A L Notkins, J-W Yoon. less Diabetologia, 2007 Aug 07; 50(10). PMID: 17676307
Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Sayuri Yamazaki, Anthony J Bonito, +3 authors, Ralph M Steinman. less Blood, 2007 Aug 19; 110(13). PMID: 17699744 Free PMC article.
Transplantation tolerance: lessons from experimental rodent models. Cherry I Kingsley, Satish N Nadig, Kathryn J Wood. Transpl Int, 2007 Aug 23; 20(10). PMID: 17711408 Free PMC article. Review.
Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Guoping Peng, Shuping Li, +3 authors, Wei Wu, Zhen Sun, Yiqiong Chen, Zhi Chen. less Immunology, 2007 Sep 04; 123(1). PMID: 17764450 Free PMC article.
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. Heather M Gibson, Carrie J Hedgcock, +4 authors, Henry K Wong. less J Immunol, 2007 Sep 06; 179(6). PMID: 17785820 Free PMC article.
Regulatory T cells in viral hepatitis. Eva Billerbeck, Tobias Bottler, Robert Thimme. World J Gastroenterol, 2007 Sep 11; 13(36). PMID: 17828817 Free PMC article. Review.
Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection. Amanda J Chase, Ahmad R Sedaghat, +4 authors, Robert F Siliciano. less J Virol, 2007 Sep 15; 81(23). PMID: 17855517 Free PMC article.
FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. Ingrid Karlsson, Benoît Malleret, +4 authors, Bruno Vaslin. less J Virol, 2007 Sep 28; 81(24). PMID: 17898053 Free PMC article.
Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression. Elizabeth H Field, Katarina Kulhankova, Mohamed E Nasr. Immunol Res, 2007 Oct 06; 39(1-3). PMID: 17917056
Resistance to apoptosis and expansion of regulatory T cells in relation to the detection of circulating tumor cells in patients with metastatic epithelial cancer. Stefanie Stanzer, Nadia Dandachi, +3 authors, Thomas Bauernhofer. less J Clin Immunol, 2007 Oct 17; 28(2). PMID: 17939021
Advancements in immune tolerance. Ping-Ying Pan, Junko Ozao, Zuping Zhou, Shu-Hsia Chen. Adv Drug Deliv Rev, 2007 Nov 03; 60(2). PMID: 17976856 Free PMC article. Review.
Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. Jane E Willoughby, Patrick S Costello, +4 authors, Richard Treisman. less J Immunol, 2007 Nov 06; 179(10). PMID: 17982074 Free PMC article.
The role of CTLA-4 in immune regulation. Johan Verhagen, Catherine A Sabatos, David C Wraith. Immunol Lett, 2007 Nov 24; 115(1). PMID: 18035425 Free PMC article.
Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier. Ana Izcue, Fiona Powrie. Immunology, 2007 Dec 25; 123(1). PMID: 18154611 Free PMC article. Review.
Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis. Shailesh R Satpute, Malarvizhi Durai, Kamal D Moudgil. Semin Arthritis Rheum, 2008 Jan 08; 38(3). PMID: 18177689 Free PMC article. Review.
Pathogen induced regulatory cell populations preventing allergy through the Th1/Th2 paradigm point of view. Thomas Roumier, Monique Capron, David Dombrowicz, Christelle Faveeuw. Immunol Res, 2008 Jan 15; 40(1). PMID: 18193360 Review.
Immune function abnormalities in peripheral blood mononuclear cell cytokine expression differentiates stages of cutaneous T-cell lymphoma/mycosis fungoides. Benjamin F Chong, Adam J Wilson, +4 authors, Henry K Wong. less Clin Cancer Res, 2008 Feb 05; 14(3). PMID: 18245523 Free PMC article.
Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease? Esaki Muthu Shankar, Ramachandran Vignesh, +7 authors, Nagalingeswaran Kumarasamy. less J Inflamm (Lond), 2008 Feb 20; 5. PMID: 18282273 Free PMC article.
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. F Stephen Hodi, Marcus Butler, +17 authors, Glenn Dranoff. less Proc Natl Acad Sci U S A, 2008 Feb 22; 105(8). PMID: 18287062 Free PMC article. Highly Cited.
Lentivirus-induced immune dysregulation. Mary B Tompkins, Wayne A Tompkins. Vet Immunol Immunopathol, 2008 Feb 22; 123(1-2). PMID: 18289702 Free PMC article. Review.
Comparative methodologies of regulatory T cell depletion in a murine melanoma model. Norimasa Matsushita, Shari A Pilon-Thomas, Lisa M Martin, Adam I Riker. J Immunol Methods, 2008 Feb 26; 333(1-2). PMID: 18295790 Free PMC article.
Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Panayotis Verginis, Katherine A McLaughlin, +2 authors, Irina Apostolou. less Proc Natl Acad Sci U S A, 2008 Feb 27; 105(9). PMID: 18299571 Free PMC article.
Regulatory T cells and human disease. Nathalie Cools, Peter Ponsaerts, Viggo F I Van Tendeloo, Zwi N Berneman. Clin Dev Immunol, 2008 Mar 05; 2007. PMID: 18317534 Free PMC article. Review.
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Dorothy K Sojka, Yu-Hui Huang, Deborah J Fowell. Immunology, 2008 Mar 19; 124(1). PMID: 18346152 Free PMC article. Review.
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Ana Izcue, Sophie Hue, +5 authors, Fiona Powrie. less Immunity, 2008 Apr 11; 28(4). PMID: 18400195 Free PMC article. Highly Cited.
Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. Christy Toms, Heidi Jessup, +3 authors, Fiona Powrie. less Immunology, 2008 May 16; 125(3). PMID: 18479351 Free PMC article.
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. Mei-Ling Chen, Bo-Shiun Yan, +2 authors, Yoshio Bando, Vijay K Kuchroo, Howard L Weiner. less J Immunol, 2008 May 21; 180(11). PMID: 18490732 Free PMC article.
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis. Honglin Wang, Thorsten Peters, +11 authors, Karin Scharffetter-Kochanek. less J Clin Invest, 2008 Jun 04; 118(7). PMID: 18521187 Free PMC article.
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion. Brian Kavanagh, Shaun O'Brien, +6 authors, Lawrence Fong. less Blood, 2008 Jun 05; 112(4). PMID: 18523152 Free PMC article.
Toll-like receptor signalling on Tregs: to suppress or not to suppress? Wendy W C van Maren, Joannes F M Jacobs, +2 authors, Gosse J Adema. less Immunology, 2008 Jun 11; 124(4). PMID: 18540962 Free PMC article. Review.
Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity. William Stohl, Noam Jacob, +6 authors, Michael N Koss. less J Immunol, 2008 Jun 21; 181(1). PMID: 18566449 Free PMC article.
How regulatory T cells work. Dario A A Vignali, Lauren W Collison, Creg J Workman. Nat Rev Immunol, 2008 Jun 21; 8(7). PMID: 18566595 Free PMC article. Highly Cited. Review.
Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation. Amanda J Chase, Hung-Chih Yang, +2 authors, Hao Zhang, Joel N Blankson, Robert F Siliciano. less J Virol, 2008 Jun 27; 82(17). PMID: 18579608 Free PMC article.
Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Wenwei Tu, Yu-Lung Lau, +6 authors, David B Lewis. less Blood, 2008 Jul 05; 112(6). PMID: 18599794 Free PMC article.
IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen. Javier Ochoa-Repáraz, Agnieszka Rynda, +6 authors, David W Pascual. less J Immunol, 2008 Jul 09; 181(2). PMID: 18606647 Free PMC article.
Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. Takayoshi Yamaza, Yasuo Miura, +11 authors, Songtao Shi. less PLoS One, 2008 Jul 10; 3(7). PMID: 18612428 Free PMC article.
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Yasushi Onishi, Zoltan Fehervari, Tomoyuki Yamaguchi, Shimon Sakaguchi. Proc Natl Acad Sci U S A, 2008 Jul 19; 105(29). PMID: 18635688 Free PMC article. Highly Cited.
Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. Yong Zheng, Claire N Manzotti, +4 authors, David M Sansom. less J Immunol, 2008 Jul 22; 181(3). PMID: 18641304 Free PMC article.
CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis. Anita L Tang, John R Teijaro, +5 authors, Donna L Farber. less J Immunol, 2008 Jul 22; 181(3). PMID: 18641318 Free PMC article.
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. Celine S Lages, Isabelle Suffia, +5 authors, Claire Chougnet. less J Immunol, 2008 Jul 22; 181(3). PMID: 18641321 Free PMC article. Highly Cited.
Gammadelta T lymphocytes: a new type of regulatory T cells suppressing murine 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Jörg C Hoffmann, Nina N Pawlowski, +3 authors, Anja A Kühl. less Int J Colorectal Dis, 2008 Jul 24; 23(10). PMID: 18649083
The IL-10 and IFN-gamma pathways are essential to the potent immunosuppressive activity of cultured CD8+ NKT-like cells. Li Zhou, Hongjie Wang, +7 authors, Jin-Xiong She. less Genome Biol, 2008 Jul 31; 9(7). PMID: 18664279 Free PMC article.
The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis. Jakob Michaëlsson, Hugo Marcelo R Barbosa, +9 authors, Esper G Kallas. less BMC Immunol, 2008 Jul 31; 9. PMID: 18664281 Free PMC article.
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Renata Mazzucchelli, Julie A Hixon, +7 authors, Scott K Durum. less Blood, 2008 Jul 31; 112(8). PMID: 18664628 Free PMC article.
Multiple sclerosis and regulatory T cells. Cristina Maria Costantino, Clare Baecher-Allan, David A Hafler. J Clin Immunol, 2008 Sep 03; 28(6). PMID: 18763026 Free PMC article. Review.
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Amanda Huber, Francesca Menconi, +2 authors, Sarah Corathers, Eric M Jacobson, Yaron Tomer. less Endocr Rev, 2008 Sep 09; 29(6). PMID: 18776148 Free PMC article. Review.
Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells. David C Gondek, Victor Devries, +4 authors, Randolph J Noelle. less J Immunol, 2008 Sep 20; 181(7). PMID: 18802078 Free PMC article.
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood. Wakae Fujimaki, Nozomu Takahashi, +6 authors, Chikao Morimoto. less Clin Dev Immunol, 2008 Sep 26; 2008. PMID: 18815628 Free PMC article.
Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis. Koichiro Watanabe, Varada P Rao, +9 authors, James G Fox. less Infect Immun, 2008 Oct 01; 76(12). PMID: 18824539 Free PMC article.
Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation. Gisen Kim, Olga Turovskaya, +4 authors, Mitchell Kronenberg. less J Immunol, 2008 Oct 04; 181(8). PMID: 18832683 Free PMC article.
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. Julia Yuen-Shan Tsang, Yakup Tanriver, +7 authors, Robert Lechler. less J Clin Invest, 2008 Oct 11; 118(11). PMID: 18846251 Free PMC article.
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Valérie Dardalhon, Amit Awasthi, +10 authors, Vijay K Kuchroo. less Nat Immunol, 2008 Nov 11; 9(12). PMID: 18997793 Free PMC article. Highly Cited.
Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. Kristian G Andersen, Tracey Butcher, Alexander G Betz. PLoS Biol, 2008 Nov 13; 6(11). PMID: 18998771 Free PMC article.
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. Flurina Meiler, Judith Zumkehr, +3 authors, Mübeccel Akdis. less J Exp Med, 2008 Nov 13; 205(12). PMID: 19001136 Free PMC article. Highly Cited.
Involvement of IL-10 in the suppression of antibody production by in vitro immunized peripheral blood mononuclear cells. Makiko Yamashita, Yoshinori Katakura, +5 authors, Sanetaka Shirahata. less Cytotechnology, 2008 Nov 13; 55(2-3). PMID: 19002996 Free PMC article.
CD25+ T cells induce Helicobacter pylori-specific CD25- T-cell anergy but are not required to maintain persistent hyporesponsiveness. Kathleen A Stuller, Hua Ding, +2 authors, Raymond W Redline, Steven J Czinn, Thomas G Blanchard. less Eur J Immunol, 2008 Nov 13; 38(12). PMID: 19003932 Free PMC article.
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Xin Yu, Kristin Harden, +9 authors, Jane L Grogan. less Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627 Highly Cited.
Induction of T regulatory cells attenuates idiopathic nephrotic syndrome. Ludmilla Le Berre, Sarah Bruneau, +7 authors, Jacques Dantal. less J Am Soc Nephrol, 2008 Nov 21; 20(1). PMID: 19020006 Free PMC article.
APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes. Yulan Jin, Xueqin Chen, +4 authors, Jin-Xiong She. less Clin Immunol, 2008 Nov 28; 130(3). PMID: 19036642 Free PMC article.
May genetic factors in fibromyalgia help to identify patients with differentially altered frequencies of immune cells? L S C Carvalho, H Correa, +5 authors, D d'Avila Reis. less Clin Exp Immunol, 2008 Nov 29; 154(3). PMID: 19037919 Free PMC article.
Neonatal bacillus Calmette-Guérin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells. Qian Li, Hua-hao Shen. Acta Pharmacol Sin, 2008 Dec 09; 30(1). PMID: 19060917 Free PMC article.
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Jianda Yuan, Sacha Gnjatic, +17 authors, Jedd D Wolchok. less Proc Natl Acad Sci U S A, 2008 Dec 17; 105(51). PMID: 19074257 Free PMC article. Highly Cited.
Immunoregulatory pathways controlling progression of autoimmunity in NOD mice. Sylvaine You, Marie-Alexandra Alyanakian, +4 authors, Lucienne Chatenoud. less Ann N Y Acad Sci, 2009 Jan 06; 1150. PMID: 19120317 Free PMC article. Review.
Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. E Bourreau, C Ronet, +6 authors, P Launois. less Infect Immun, 2009 Jan 27; 77(4). PMID: 19168733 Free PMC article.
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants. Marta Barreto, Ricardo C Ferreira, +12 authors, Astrid M Vicente. less BMC Immunol, 2009 Jan 29; 10. PMID: 19173720 Free PMC article.
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. Randall H Friedline, David S Brown, +7 authors, Cynthia A Chambers. less J Exp Med, 2009 Feb 04; 206(2). PMID: 19188497 Free PMC article. Highly Cited.
Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge. Jared H Rowe, Tanner M Johanns, +2 authors, James M Ertelt, Joseph C Lai, Sing Sing Way. less Immunology, 2009 Feb 05; 128(1 Suppl). PMID: 19191906 Free PMC article.
Treatment of Crohn's disease with colony-stimulating factors: An overview. Luisa Guidi, Giammarco Mocci, Manuela Marzo, Sergio Rutella. Ther Clin Risk Manag, 2009 Feb 12; 4(5). PMID: 19209275 Free PMC article.
Reduced circulating CD4+CD25+ cell populations in haemorrhagic fever with renal syndrome. L Y Zhu, L J Chi, X Wang, H Zhou. Clin Exp Immunol, 2009 Feb 13; 156(1). PMID: 19210520 Free PMC article.
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Johan Verhagen, Leona Gabrysová, +4 authors, David C Wraith. less Proc Natl Acad Sci U S A, 2009 Feb 17; 106(9). PMID: 19218450 Free PMC article.
Effects of oral commensal and pathogenic bacteria on human dendritic cells. T Chino, D M Santer, +5 authors, E A Clark. less Oral Microbiol Immunol, 2009 Feb 26; 24(2). PMID: 19239635 Free PMC article.
Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets. Maria Nikolova, Jean-Daniel Lelievre, +2 authors, Matthieu Carriere, Armand Bensussan, Yves Lévy. less Blood, 2009 Feb 28; 113(19). PMID: 19246340 Free PMC article.
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. Nobuhiro Nakamoto, Hyosun Cho, +8 authors, Kyong-Mi Chang. less PLoS Pathog, 2009 Feb 28; 5(2). PMID: 19247441 Free PMC article. Highly Cited.
Regulatory T cells overturned: the effectors fight back. Lucy S K Walker. Immunology, 2009 Mar 13; 126(4). PMID: 19278420 Free PMC article. Review.
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Ulrike Lorenz. Immunol Rev, 2009 Mar 18; 228(1). PMID: 19290938 Free PMC article. Highly Cited. Review.
Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress. Andrea L Szymczak-Workman, Creg J Workman, Dario A A Vignali. J Immunol, 2009 Apr 22; 182(9). PMID: 19380762 Free PMC article.
CD4+ lymphocytes modulate prostate cancer progression in mice. Theofilos Poutahidis, Varada P Rao, +7 authors, Susan E Erdman. less Int J Cancer, 2009 May 02; 125(4). PMID: 19408303 Free PMC article.
Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. Lauren W Collison, Meenu R Pillai, Vandana Chaturvedi, Dario A A Vignali. J Immunol, 2009 May 06; 182(10). PMID: 19414764 Free PMC article.
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Hélène Bour-Jordan, Jeffrey A Bluestone. Immunol Rev, 2009 May 12; 229(1). PMID: 19426214 Free PMC article. Review.
CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation. Dorothy K Sojka, Angela Hughson, Deborah J Fowell. Eur J Immunol, 2009 May 23; 39(6). PMID: 19462377 Free PMC article.
Molecular orchestration of differentiation and function of regulatory T cells. Li-Fan Lu, Alexander Rudensky. Genes Dev, 2009 Jun 03; 23(11). PMID: 19487568 Free PMC article.
Colitis-associated cancer: the role of T cells in tumor development. Maximilian J Waldner, Markus F Neurath. Semin Immunopathol, 2009 Jun 06; 31(2). PMID: 19495757 Review.
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis. C Coquerelle, G Oldenhove, +6 authors, M Moser. less Gut, 2009 Jun 10; 58(10). PMID: 19505881 Free PMC article.
Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells. James D Lord, Robert C Hackman, +5 authors, George B McDonald. less Dig Dis Sci, 2009 Jun 10; 55(5). PMID: 19507029 Free PMC article.
Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population. Belén Blanco, José A Pérez-Simón, +10 authors, Jesús F San Miguel. less Haematologica, 2009 Jun 11; 94(7). PMID: 19508976 Free PMC article.
Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. Caroline E von Allmen, Nicole Schmitz, +8 authors, Martin F Bachmann. less Proc Natl Acad Sci U S A, 2009 Jul 01; 106(28). PMID: 19564598 Free PMC article.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. Karl S Peggs, Sergio A Quezada, +2 authors, Cynthia A Chambers, Alan J Korman, James P Allison. less J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407 Free PMC article. Highly Cited.
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice. Carol H Miao, Benjamin R Harmeling, +8 authors, David J Rawlings. less Blood, 2009 Aug 29; 114(19). PMID: 19713458 Free PMC article.
How do regulatory T cells work? A Corthay. Scand J Immunol, 2009 Sep 16; 70(4). PMID: 19751267 Free PMC article. Highly Cited. Review.
Regulatory T cells and immune tolerance to tumors. Xuefang Cao. Immunol Res, 2009 Sep 19; 46(1-3). PMID: 19763889 Review.
Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms. Mei-Ling Chen, Bo-Shiun Yan, Deneen Kozoriz, Howard L Weiner. Eur J Immunol, 2009 Sep 22; 39(12). PMID: 19768696 Free PMC article.
The role of costimulatory molecules in allergic disease and asthma. Vincent Lombardi, Abinav K Singh, Omid Akbari. Int Arch Allergy Immunol, 2009 Sep 30; 151(3). PMID: 19786798 Free PMC article. Review.
Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation. R A O'Connor, L S Taams, S M Anderton. Clin Exp Immunol, 2009 Nov 17; 159(2). PMID: 19912249 Free PMC article. Review.
Immune tolerance induction by integrating innate and adaptive immune regulators. Jun Suzuki, Camillo Ricordi, Zhibin Chen. Cell Transplant, 2009 Nov 19; 19(3). PMID: 19919733 Free PMC article. Review.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention. William Humphries, Jun Wei, John H Sampson, Amy B Heimberger. Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972 Free PMC article. Review.
CD4(+)CD25(+) regulatory T cells resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis. Nagendra Singh, Mutsumi Yamamoto, +4 authors, Makio Iwashima. less J Immunol, 2009 Dec 02; 184(1). PMID: 19949106 Free PMC article.
TLR2-independent induction and regulation of chronic intestinal inflammation. Olivier Boulard, Mark J Asquith, Fiona Powrie, Kevin J Maloy. Eur J Immunol, 2009 Dec 02; 40(2). PMID: 19950179 Free PMC article.
Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Kajsa Wing, Shimon Sakaguchi. Nat Immunol, 2009 Dec 18; 11(1). PMID: 20016504 Highly Cited. Review.
Gatekeepers of intestinal inflammation. Heather A Arnett, Joanne L Viney. Inflamm Res, 2010 Jan 13; 59(1). PMID: 20066780 Review.
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity. Nitya Jain, Hai Nguyen, Cynthia Chambers, Joonsoo Kang. Proc Natl Acad Sci U S A, 2010 Jan 19; 107(4). PMID: 20080649 Free PMC article.
Fiona Powrie: Gut diplomacy. Interview by Amy Maxmen. Fiona Powrie. J Exp Med, 2010 Jan 20; 207(1). PMID: 20083579 Free PMC article.
Short-term administrations of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induce tolerance to neonatal porcine islet xenografts in mice. Hossein Arefanian, Eric B Tredget, +3 authors, Gina R Rayat. less Diabetes, 2010 Jan 21; 59(4). PMID: 20086231 Free PMC article.
Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells. Shuzi Zhang, Hehua Dai, +2 authors, Ni Wan, Yolonda Moore, Zhenhua Dai. less PLoS One, 2010 Jan 22; 5(1). PMID: 20090908 Free PMC article.
Association of two clones allows for optimal detection of human FOXP3. Pietro Presicce, Maria E Moreno-Fernandez, +2 authors, Celine S Lages, Kris I Orsborn, Claire A Chougnet. less Cytometry A, 2010 Feb 18; 77(6). PMID: 20162533 Free PMC article.
Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases. Franco Pandolfi, Rossella Cianci, +2 authors, Danilo Pagliari, Raffaele Landolfi, Giovanni Cammarota. less Mediators Inflamm, 2010 Feb 20; 2009. PMID: 20169125 Free PMC article. Review.
Regulatory T cells: roles of T cell receptor for their development and function. Naganari Ohkura, Shimon Sakaguchi. Semin Immunopathol, 2010 Feb 25; 32(2). PMID: 20179931 Review.
Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Aya M Westbrook, Akos Szakmary, Robert H Schiestl. Mutat Res, 2010 Mar 20; 705(1). PMID: 20298806 Free PMC article. Review.
A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma. Marie-Denise Poirier, Houda Haban, Abdeljabar El Andaloussi. J Oncol, 2009 Jan 01; 2009. PMID: 20339520 Free PMC article.
Proliferation of CD4CD25Foxp3 regulatory T lymphocytes in ex vivo expanded ascitic fluid from primary and recurrent ovarian carcinoma. Shin Wha Lee, Yong-Man Kim, +4 authors, Young-Tak Kim. less J Gynecol Oncol, 2010 Apr 10; 21(1). PMID: 20379446 Free PMC article.
CD8alpha+ dendritic cells prime TCR-peptide-reactive regulatory CD4+FOXP3- T cells. Trevor R F Smith, Igor Maricic, +2 authors, Francesco Ria, Susan Schneider, Vipin Kumar. less Eur J Immunol, 2010 Apr 16; 40(7). PMID: 20394075 Free PMC article.
E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Karima R R Siddiqui, Sophie Laffont, Fiona Powrie. Immunity, 2010 Apr 20; 32(4). PMID: 20399121 Free PMC article. Highly Cited.
CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population. Farha Deeba, Rabbani Syed, +3 authors, Hanmanth Rao. less Indian J Dermatol, 2010 Apr 27; 55(1). PMID: 20418973 Free PMC article.
Is aspirin treatment an appropriate intervention to osteoporosis? Songtao Shi, Takayoshi Yamaza, Kentaro Akiyama. Fut Rheumatol, 2008 Dec 01; 3(6). PMID: 20428329 Free PMC article.
The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells. Pu Feng, Hong Wang, +2 authors, Roy S Feldman, Edmund A Pribitkin, Paul A S Breslin. less Chem Senses, 2010 May 12; 35(6). PMID: 20457570 Free PMC article.
In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus. S Rochelle Mikkelsen, Stacie K Reckling, Erin A Egan, Gregg A Dean. Virology, 2010 May 18; 403(2). PMID: 20471053 Free PMC article.
CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model. Haruei Ogino, Kazuhiko Nakamura, +2 authors, Eikich Ihara, Hirotada Akiho, Ryoichi Takayanagi. less Dig Dis Sci, 2010 Jun 04; 56(2). PMID: 20521112
The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease. Ondrej Hradsky, Petra Dusatkova, +6 authors, Ondrej Cinek. less BMC Med Genet, 2010 Jun 12; 11. PMID: 20537165 Free PMC article.
Modulation of CTLA-4 and GITR for cancer immunotherapy. Francesca Avogadri, Jianda Yuan, +2 authors, Arvin Yang, David Schaer, Jedd D Wolchok. less Curr Top Microbiol Immunol, 2010 Jun 22; 344. PMID: 20563707 Free PMC article. Review.
The PD-1 pathway in tolerance and autoimmunity. Loise M Francisco, Peter T Sage, Arlene H Sharpe. Immunol Rev, 2010 Jul 20; 236. PMID: 20636820 Free PMC article. Highly Cited. Review.
Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. Ross B Fulton, David K Meyerholz, Steven M Varga. J Immunol, 2010 Jul 20; 185(4). PMID: 20639494 Free PMC article. Highly Cited.
Therapeutic potential of TGF-β-induced CD4(+) Foxp3(+) regulatory T cells in autoimmune diseases. Xiaohui Zhou, Ning Kong, +4 authors, Song Guo Zheng. less Autoimmunity, 2010 Jul 31; 44(1). PMID: 20670119 Free PMC article. Review.
Gene expression profiling of the local cecal response of genetic chicken lines that differ in their susceptibility to Campylobacter jejuni colonization. Xianyao Li, Christina L Swaggerty, +5 authors, Huaijun Zhou. less PLoS One, 2010 Aug 03; 5(7). PMID: 20676366 Free PMC article.
Checks and balances: IL-23 in the intestine. Samuel Huber, Richard A Flavell. Immunity, 2010 Aug 25; 33(2). PMID: 20732638 Free PMC article.
Interleukin-23 drives intestinal inflammation through direct activity on T cells. Philip P Ahern, Chris Schiering, +4 authors, Fiona Powrie. less Immunity, 2010 Aug 25; 33(2). PMID: 20732640 Free PMC article. Highly Cited.
IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions. Cécile Le Saout, Marine Villard, +3 authors, Javier Hernandez. less PLoS One, 2010 Sep 22; 5(9). PMID: 20856822 Free PMC article.
Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells. Carol H Miao. Expert Rev Hematol, 2010 Oct 27; 3(4). PMID: 20976115 Free PMC article. Review.
Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination. Matteo Vergati, Vittore Cereda, +7 authors, Kwong Y Tsang. less Cancer Immunol Immunother, 2010 Oct 27; 60(2). PMID: 20976449 Free PMC article.
Evaluation of the immunoregulatory activity of intraepithelial lymphocytes in a mouse model of chronic intestinal inflammation. D V Ostanin, C M Brown, +2 authors, L Gray, S Bharwani, M B Grisham. less Int Immunol, 2010 Nov 13; 22(12). PMID: 21071622 Free PMC article.
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy. Margaret K Callahan, Jedd D Wolchok, James P Allison. Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074063 Free PMC article. Review.
T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD. Amir J Guri, Nicholas P Evans, Raquel Hontecillas, Josep Bassaganya-Riera. J Nutr Biochem, 2010 Nov 27; 22(9). PMID: 21109419 Free PMC article.
IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression. Kathrin Eller, Dominik Wolf, +6 authors, Anna M Wolf. less J Immunol, 2010 Dec 01; 186(1). PMID: 21115728 Free PMC article.
The role of natural regulatory T cells in infection. Ana M Sanchez, Yiping Yang. Immunol Res, 2010 Dec 01; 49(1-3). PMID: 21116872 Free PMC article. Review.
Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu. Anagha A Divekar, Shweta Dubey, Pallavi R Gangalum, Ram Raj Singh. J Immunol, 2010 Dec 15; 186(2). PMID: 21149603 Free PMC article.
The type of responder T-cell has a significant impact in a human in vitro suppression assay. Srikanta Jana, Hope Campbell, +5 authors, Sanja Glisic. less PLoS One, 2010 Dec 15; 5(12). PMID: 21151941 Free PMC article.
Role of CD4CD25FOXP3 Regulatory T Cells in Psoriasis. Woo-Jin Yun, Deok-Woo Lee, +8 authors, Jee-Ho Choi. less Ann Dermatol, 2010 Dec 18; 22(4). PMID: 21165208 Free PMC article.
Releasing the brake on the immune system: ipilimumab in melanoma and other tumors. Ahmad Tarhini, Ernest Lo, David R Minor. Cancer Biother Radiopharm, 2011 Jan 06; 25(6). PMID: 21204754 Free PMC article. Review.
Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells. R C Dutra, M Cola, +5 authors, J B Calixto. less Br J Pharmacol, 2011 Jan 20; 163(2). PMID: 21244371 Free PMC article.
T-cell subset regulation in atopy. Marek Jutel, Cezmi A Akdis. Curr Allergy Asthma Rep, 2011 Jan 29; 11(2). PMID: 21271314 Free PMC article. Review.
In vitro Treg suppression assays. Lauren W Collison, Dario A A Vignali. Methods Mol Biol, 2011 Feb 03; 707. PMID: 21287326 Free PMC article.
Genetic susceptibility to autoimmune liver disease. Jochen Mattner. World J Hepatol, 2011 Feb 11; 3(1). PMID: 21307981 Free PMC article.
Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: tools for allogeneic transplantation. Scott S Graves, Diane M Stone, +6 authors, Rainer Storb. less Transplantation, 2011 Feb 24; 91(8). PMID: 21343872 Free PMC article.
Allogeneic apoptotic thymocyte-stimulated dendritic cells expand functional regulatory T cells. Thaís Boccia da Costa, Luiz R Sardinha, +2 authors, Rafael Larocca, Jean P S Peron, Luiz V Rizzo. less Immunology, 2011 Mar 02; 133(1). PMID: 21355864 Free PMC article.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom. less Science, 2011 Apr 09; 332(6029). PMID: 21474713 Free PMC article. Highly Cited.
Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations. Jochen Maul, Martin Zeitz. Langenbecks Arch Surg, 2011 Apr 12; 397(1). PMID: 21479621 Review.
In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. James C Lee, Erik Hayman, +4 authors, Renier Brentjens. less Cancer Res, 2011 Apr 14; 71(8). PMID: 21487038 Free PMC article.
Treatment with IP-10 induces host-protective immune response by regulating the T regulatory cell functioning in Leishmania donovani-infected mice. Gaurav Gupta, Saikat Majumdar, +4 authors, Subrata Majumdar. less Med Microbiol Immunol, 2011 May 03; 200(4). PMID: 21533785
Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. André Hoerning, Kerith Koss, +9 authors, David M Briscoe. less Eur J Immunol, 2011 May 04; 41(8). PMID: 21538345 Free PMC article.
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. Todd V Brennan, Qizhi Tang, +4 authors, Sang-Mo Kang. less J Surg Res, 2011 May 17; 169(1). PMID: 21571317 Free PMC article.
Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity. Masako Nakanishi, Antoine Menoret, +4 authors, Daniel W Rosenberg. less Cancer Prev Res (Phila), 2011 May 18; 4(8). PMID: 21576350 Free PMC article.
The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. Kay D Gerold, Peilin Zheng, +3 authors, Stephan Kissler. less Diabetes, 2011 May 24; 60(7). PMID: 21602513 Free PMC article.
The variation of CD4+CD25+ regulatory T cells in the periphery blood and tumor microenvironment of non-small cell lung cancer patients and the downregulation effects induced by CpG ODN. Yan-Ying Wang, Xiao-Ye He, +2 authors, Ying-Yun Cai, Zhi-Jun Wang, Shao-Hua Lu. less Target Oncol, 2011 May 26; 6(3). PMID: 21611754
Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice. Eva Gückel, Silke Frey, +3 authors, Reinhard E Voll. less PLoS One, 2011 Jun 01; 6(5). PMID: 21625598 Free PMC article.
Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells. Xin Chen, Joost J Oppenheim. Int Immunopharmacol, 2011 Jun 04; 11(10). PMID: 21635972 Free PMC article. Review.
Regulatory T cells phenotype in different clinical forms of Chagas' disease. Fernanda Fortes de Araújo, Danielle Marquete Vitelli-Avelar, +8 authors, Olindo Assis Martins-Filho. less PLoS Negl Trop Dis, 2011 Jun 10; 5(5). PMID: 21655351 Free PMC article. Review.
Transplantation tolerance: Clinical potential of regulatory T cells. Yannick D Muller, Jörg D Seebach, +2 authors, Leo H Bühler, Manuel Pascual, Dela Golshayan. less Self Nonself, 2011 Jul 22; 2(1). PMID: 21776332 Free PMC article.
Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling. Felipe Saldanha-Araujo, Rodrigo Haddad, +8 authors, Rodrigo A Panepucci. less J Cell Mol Med, 2011 Jul 23; 16(6). PMID: 21777379 Free PMC article.
Characterization of antigenic variants of hepatitis C virus in immune evasion. Jane H Wang, Matthew J Pianko, +6 authors, Lijun Rong. less Virol J, 2011 Aug 02; 8. PMID: 21801418 Free PMC article.
Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis. Narendra P Singh, Udai P Singh, +3 authors, Prakash S Nagarkatti. less PLoS One, 2011 Aug 23; 6(8). PMID: 21858153 Free PMC article. Highly Cited.
Intravenous injection of endogenous microbial components abrogates DSS-induced colitis. Beate C Sydora, Eric J Albert, +3 authors, Richard N Fedorak. less Dig Dis Sci, 2011 Sep 02; 57(2). PMID: 21881971
Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). Henry K Wong, Anjali Mishra, Timothy Hake, Pierluigi Porcu. Br J Haematol, 2011 Sep 03; 155(2). PMID: 21883142 Free PMC article. Review.
Regulatory T cell: a protection for tumour cells. Yi Wang, Yushui Ma, +4 authors, Xizhong Shen. less J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966 Free PMC article. Review.
Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors. Derek A Wainwright, Sadhak Sengupta, Yu Han, Maciej S Lesniak. Neuro Oncol, 2011 Sep 13; 13(12). PMID: 21908444 Free PMC article.
Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy. Kathrin Eller, Alexander Kirsch, +7 authors, Philipp Eller. less Diabetes, 2011 Sep 14; 60(11). PMID: 21911743 Free PMC article. Highly Cited.
Influence of short-term glucocorticoid therapy on regulatory T cells in vivo. Silviu Sbiera, Thomas Dexneit, +10 authors, Martin Fassnacht. less PLoS One, 2011 Sep 14; 6(9). PMID: 21912688 Free PMC article.
GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. Elizabeth A Wohlfert, John R Grainger, +14 authors, Yasmine Belkaid. less J Clin Invest, 2011 Oct 04; 121(11). PMID: 21965331 Free PMC article. Highly Cited.
Inflammatory bowel disease: is it a primary immunodeficiency? Erik Glocker, Bodo Grimbacher. Cell Mol Life Sci, 2011 Oct 15; 69(1). PMID: 21997382 Review.
Induction of contact-dependent CD8(+) regulatory T cells through stimulation with staphylococcal and streptococcal superantigens. Amanda L Taylor, Elizabeth L A Cross, Martin J Llewelyn. Immunology, 2011 Nov 03; 135(2). PMID: 22043981 Free PMC article.
Identification of a unique double-negative regulatory T-cell population. Byung O Lee, Joyce E Jones, +5 authors, David R Milich. less Immunology, 2011 Nov 03; 134(4). PMID: 22044159 Free PMC article.
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance. Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier. Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524 Free PMC article. Review.
T regulatory cells in B-cell malignancy - tumour support or kiss of death? Camilla A Lindqvist, Angelica S I Loskog. Immunology, 2011 Nov 25; 135(4). PMID: 22112044 Free PMC article. Review.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Lucy S K Walker, David M Sansom. Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087 Highly Cited.
Lung function early after lung transplantation is correlated with the frequency of regulatory T cells. Tomoyuki Nakagiri, Gregor Warnecke, +12 authors, Martin Strüber. less Surg Today, 2011 Dec 17; 42(3). PMID: 22173646
Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury. Li-Wen Lai, Kim-Chong Yong, Yeong-Hau H Lien. Kidney Int, 2011 Dec 23; 81(10). PMID: 22189844 Free PMC article.
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Christopher Jackson, Jacob Ruzevick, +2 authors, Jillian Phallen, Zineb Belcaid, Michael Lim. less Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190972 Free PMC article. Review.
Regulatory T cells: mechanisms of differentiation and function. Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky. Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781 Free PMC article. Highly Cited. Review.
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. Aymeric Rivollier, Jianping He, +2 authors, Abhisake Kole, Vassilis Valatas, Brian L Kelsall. less J Exp Med, 2012 Jan 11; 209(1). PMID: 22231304 Free PMC article. Highly Cited.
Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. Yong Chen, Shudan Shen, +2 authors, Balachandra K Gorentla, Jimin Gao, Xiao-Ping Zhong. less J Immunol, 2012 Jan 11; 188(4). PMID: 22231701 Free PMC article.
Targeting regulatory T cells. Christine Ménétrier-Caux, Tyler Curiel, +3 authors, Weiping Zou. less Target Oncol, 2012 Feb 14; 7(1). PMID: 22327882 Review.
Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis. Saleh A Naser, Melissa Arce, +4 authors, Saisathya Thanigachalam. less World J Gastroenterol, 2012 Feb 22; 18(5). PMID: 22346247 Free PMC article. Review.
Correlation between the cord vitamin D levels and regulatory T cells in newborn infants. Ayşegül Güven, Ayşe Ecevit, +3 authors, Namık Ozbek. less Eur J Pediatr, 2012 Mar 03; 171(8). PMID: 22383070
Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Shounan Yi, Ming Ji, +4 authors, Philip J O'Connell. less Diabetes, 2012 Mar 10; 61(5). PMID: 22403295 Free PMC article.
Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid. Mojgan Zadeh, Mohammad W Khan, +4 authors, Mansour Mohamadzadeh. less J Inflamm (Lond), 2012 Mar 20; 9. PMID: 22423982 Free PMC article.
Regulation generation: the suppressive functions of human regulatory T cells. Wendy A Goodman, Kevin D Cooper, Thomas S McCormick. Crit Rev Immunol, 2012 Mar 21; 32(1). PMID: 22428855 Free PMC article. Review.
Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism. Guilin Qiao, Lifen Yang, +4 authors, Jian Zhang. less Clin Immunol, 2012 Mar 31; 143(2). PMID: 22459706 Free PMC article.
Regulatory T cells in human ovarian cancer. Dong-Jun Peng, Rebecca Liu, Weiping Zou. J Oncol, 2012 Apr 07; 2012. PMID: 22481922 Free PMC article.
Immunoregulation by the gut microbiota. Junko Nishio, Kenya Honda. Cell Mol Life Sci, 2012 Apr 25; 69(21). PMID: 22527722 Review.
Requirements for growth and IL-10 expression of highly purified human T regulatory cells. Benedetta Bonacci, Brandon Edwards, +4 authors, James W Verbsky. less J Clin Immunol, 2012 May 09; 32(5). PMID: 22562448 Free PMC article.
Molecular mechanisms of treg-mediated T cell suppression. Angelika Schmidt, Nina Oberle, Peter H Krammer. Front Immunol, 2012 May 09; 3. PMID: 22566933 Free PMC article. Highly Cited.
On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation. Anja U Engela, Carla C Baan, +2 authors, Frank J M F Dor, Willem Weimar, Martin J Hoogduijn. less Front Immunol, 2012 May 26; 3. PMID: 22629256 Free PMC article.
Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation? Francisco Salcido-Ochoa, Nurhashikin Yusof, +3 authors, Olaf Rotzschke. less J Transplant, 2012 Jun 13; 2012. PMID: 22690325 Free PMC article.
Boosting regulatory T cell function by CD4 stimulation enters the clinic. Christian Becker, Tobias Bopp, Helmut Jonuleit. Front Immunol, 2012 Jun 22; 3. PMID: 22719741 Free PMC article.
Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance. Mara Kornete, Ciriaco A Piccirillo. Front Immunol, 2012 Jun 28; 3. PMID: 22737152 Free PMC article.
Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells. Chun Jing Wang, Rupert Kenefeck, +6 authors, Lucy S K Walker. less J Immunol, 2012 Jul 04; 189(3). PMID: 22753931 Free PMC article.
Homeostasis and function of regulatory T cells in HIV/SIV infection. Maria E Moreno-Fernandez, Pietro Presicce, Claire A Chougnet. J Virol, 2012 Jul 20; 86(19). PMID: 22811537 Free PMC article. Review.
Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Weihua Zhao, David R Beers, +2 authors, Bing Liao, Jenny S Henkel, Stanley H Appel. less Neurobiol Dis, 2012 Jul 24; 48(3). PMID: 22820142 Free PMC article.
Autologous regulatory T cells for the treatment of type 1 diabetes. James A Thompson, Daniel Perry, Todd M Brusko. Curr Diab Rep, 2012 Jul 31; 12(5). PMID: 22843491 Review.
Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation. Leela Rani Avula, Dries Knapen, +4 authors, Jean-Pierre Timmermans. less BMC Genomics, 2012 Aug 08; 13. PMID: 22866923 Free PMC article.
CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria. M J Barnes, T Griseri, +3 authors, A M F Johnson, W Young, F Powrie, A Izcue. less Mucosal Immunol, 2012 Aug 23; 6(2). PMID: 22910217 Free PMC article.
Does the PI3K pathway promote or antagonize regulatory T cell development and function? Dalya R Soond, Elizabeth C M Slack, +2 authors, Oliver A Garden, Daniel T Patton, Klaus Okkenhaug. less Front Immunol, 2012 Aug 23; 3. PMID: 22912633 Free PMC article.
Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells. Rafael M Rezende, Rafael P Oliveira, +10 authors, Ana M C Faria. less J Autoimmun, 2012 Sep 04; 40. PMID: 22939403 Free PMC article.
Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression. Leticia Corrales, Daniel Ajona, +7 authors, Ruben Pio. less J Immunol, 2012 Oct 03; 189(9). PMID: 23028051 Free PMC article. Highly Cited.
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal. Yuning Lu, Helga Schneider, Christopher E Rudd. Blood, 2012 Oct 11; 120(23). PMID: 23047820 Free PMC article.
The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells. Andrea Balogh, Eszter Persa, +4 authors, Katalin Lumniczky. less Inflamm Res, 2012 Oct 20; 62(2). PMID: 23080082
Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions. Joshua F Heiber, Terrence L Geiger. Cell Immunol, 2012 Oct 24; 279(1). PMID: 23089195 Free PMC article. Review.
Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes. Yoshiki Shigematsu, Takeshi Hanagiri, +8 authors, Fumihiro Tanaka. less Oncol Lett, 2012 Dec 04; 4(4). PMID: 23205074 Free PMC article.
The role of B7 family molecules in hematologic malignancy. Paul Greaves, John G Gribben. Blood, 2012 Dec 12; 121(5). PMID: 23223433 Free PMC article. Review.
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go? V Kumar. Purinergic Signal, 2012 Dec 29; 9(2). PMID: 23271562 Free PMC article. Review.
A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes. Gisen Kim, Ryo Shinnakasu, +2 authors, Mitchell Kronenberg. less J Immunol, 2013 Jan 22; 190(4). PMID: 23335749 Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation. Sheng Yao, Yuwen Zhu, Lieping Chen. Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250 Free PMC article. Highly Cited. Review.
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells. Wing-hong Kwan, William van der Touw, +2 authors, Estela Paz-Artal, Ming O Li, Peter S Heeger. less J Exp Med, 2013 Feb 06; 210(2). PMID: 23382542 Free PMC article. Highly Cited.
CD4(+) T-cell subsets in intestinal inflammation. Matthew Shale, Chris Schiering, Fiona Powrie. Immunol Rev, 2013 Feb 15; 252(1). PMID: 23405904 Free PMC article. Review.
Functional complexity of the Leishmania granuloma and the potential of in silico modeling. John W J Moore, Daniel Moyo, +3 authors, Paul M Kaye. less Front Immunol, 2013 Feb 21; 4. PMID: 23423646 Free PMC article.
The nature of activatory and tolerogenic dendritic cell-derived signal II. Ghaith Bakdash, Simone P Sittig, +2 authors, Tjeerd van Dijk, Carl G Figdor, I Jolanda M de Vries. less Front Immunol, 2013 Mar 02; 4. PMID: 23450201 Free PMC article.
Molecular signatures of T-cell inhibition in HIV-1 infection. Marie Larsson, Esaki M Shankar, +5 authors, Adeeba Kamarulzaman. less Retrovirology, 2013 Mar 22; 10. PMID: 23514593 Free PMC article. Review.
Nutritional protective mechanisms against gut inflammation. Monica Viladomiu, Raquel Hontecillas, +2 authors, Lijuan Yuan, Pinyi Lu, Josep Bassaganya-Riera. less J Nutr Biochem, 2013 Apr 02; 24(6). PMID: 23541470 Free PMC article. Review.
Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes. M Pihl, L Akerman, +5 authors, R Casas. less Clin Exp Immunol, 2013 Apr 23; 172(3). PMID: 23600827 Free PMC article.
Indoleamine 2,3 dioxygenase contributes to transferable tolerance in rat red blood cell inducible model of experimental autoimmune haemolytic anaemia. L N Dahal, L S Hall, R N Barker, F J Ward. Clin Exp Immunol, 2013 Apr 24; 173(1). PMID: 23607691 Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. Andrew M Intlekofer, Craig B Thompson. J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198 Free PMC article. Highly Cited. Review.
Monitoring regulatory immune responses in tumor immunotherapy clinical trials. Brian M Olson, Douglas G McNeel. Front Oncol, 2013 May 09; 3. PMID: 23653893 Free PMC article.
Leptin antagonist ameliorates chronic colitis in IL-10⁻/⁻ mice. Udai P Singh, Narendra P Singh, +7 authors, Prakash S Nagarkatti. less Immunobiology, 2013 Jun 04; 218(12). PMID: 23726523 Free PMC article.
Analysis of circulating regulatory T cells (CD4+CD25+CD127-) after cryosurgery in prostate cancer. Tong-Guo Si, Jun-Ping Wang, Zhi Guo. Asian J Androl, 2013 Jun 04; 15(4). PMID: 23728588 Free PMC article.
The role of the immune system in governing host-microbe interactions in the intestine. Eric M Brown, Manish Sadarangani, B Brett Finlay. Nat Immunol, 2013 Jun 20; 14(7). PMID: 23778793 Highly Cited. Review.
Treatment of graft-versus-host disease with naturally occurring T regulatory cells. Piotr Trzonkowski, Anna Dukat-Mazurek, +6 authors, Andrzej Hellmann. less BioDrugs, 2013 Jul 03; 27(6). PMID: 23813436 Free PMC article. Review.
The emerging role of leptin antagonist as potential therapeutic option for inflammatory bowel disease. Udai P Singh, Narendra P Singh, +7 authors, Prakash S Nagarkatti. less Int Rev Immunol, 2013 Jul 12; 33(1). PMID: 23841494 Free PMC article. Review.
Treg and CTLA-4: two intertwining pathways to immune tolerance. Lucy S K Walker. J Autoimmun, 2013 Jul 16; 45. PMID: 23849743 Free PMC article. Highly Cited. Review.
Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells. Cong Wu, Yi Zhang, +5 authors, Guoyou Chen. less Cell Mol Immunol, 2013 Jul 23; 10(5). PMID: 23872920 Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
T cell Receptor Signal Transduction in T lymphocytes. Balachandra K Gorentla, Xiao-Ping Zhong. J Clin Cell Immunol, 2013 Aug 16; 2012(Suppl 12). PMID: 23946894 Free PMC article.
CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β. Christine M Deppong, Traci L Bricker, +3 authors, Jonathan M Green. less J Immunol, 2013 Aug 21; 191(6). PMID: 23956428 Free PMC article.
ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection. Qiang Wu, Gail J Gardiner, +11 authors, Rebecca A Shilling. less PLoS One, 2013 Aug 24; 8(8). PMID: 23967339 Free PMC article.
PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3. Pin Zhang, Takashi Maruyama, +4 authors, Wanjun Chen. less PLoS One, 2013 Aug 27; 8(8). PMID: 23977081 Free PMC article.
Regulatory T cells and Atherosclerosis. Jahaira Lopez Pastrana, Xiaojin Sha, +5 authors, Xiao-Feng Yang. less J Clin Exp Cardiolog, 2013 Sep 03; 2012(Suppl 12). PMID: 23997979 Free PMC article.
FOXP3⁺ T regulatory cell modifications in inflammatory bowel disease patients treated with anti-TNFα agents. Luisa Guidi, Carla Felice, +11 authors, Sergio Rutella. less Biomed Res Int, 2013 Sep 26; 2013. PMID: 24063002 Free PMC article.
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis. Su-Jin Moon, Jin-Sil Park, +11 authors, Mi-La Cho. less Exp Mol Med, 2013 Oct 05; 45. PMID: 24091748 Free PMC article.
Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. Qiuming He, Y Maurice Morillon, +5 authors, Roland Tisch. less J Immunol, 2013 Nov 08; 191(12). PMID: 24198282 Free PMC article.
Regulatory T cells in colorectal cancer: from biology to prognostic relevance. Dimitrios Mougiakakos. Cancers (Basel), 2011 Jan 01; 3(2). PMID: 24212779 Free PMC article.
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases. James W Verbsky, Talal A Chatila. Curr Opin Pediatr, 2013 Nov 19; 25(6). PMID: 24240290 Free PMC article. Review.
Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes. Altin Gjymishka, Roxana M Coman, Todd M Brusko, Sarah C Glover. Immunotherapy, 2013 Nov 29; 5(12). PMID: 24283846 Free PMC article. Review.
ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner. Jian Zheng, Ping-Lung Chan, +6 authors, Wenwei Tu. less PLoS One, 2013 Dec 07; 8(12). PMID: 24312642 Free PMC article.
Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice. V Dugas, A Liston, +6 authors, S Lesage. less Genes Immun, 2013 Dec 18; 15(2). PMID: 24335706
Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go. Angela Vasaturo, Stefania Di Blasio, +4 authors, Stanleyson V Hato. less Front Immunol, 2013 Dec 19; 4. PMID: 24348481 Free PMC article. Review.
Efficient expansion of cryopreserved CD4(+)CD25(+)CD127(lo/-) cells in Type 1 diabetes. Anna Rydén, Maria Faresjö. Results Immunol, 2011 Jan 01; 1(1). PMID: 24371551 Free PMC article.
Mechanisms of immune tolerance to allergens in children. Umut C Kucuksezer, Cevdet Ozdemir, Mübeccel Akdis, Cezmi A Akdis. Korean J Pediatr, 2014 Jan 15; 56(12). PMID: 24416044 Free PMC article. Review.
CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells. Cecilia Fernandez-Ponce, Margarita Dominguez-Villar, Enrique Aguado, Francisco Garcia-Cozar. PLoS One, 2014 Jan 28; 9(1). PMID: 24465502 Free PMC article.
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity. Mathieu Angin, Paul L Klarenbeek, +10 authors, Marylyn M Addo. less PLoS One, 2014 Feb 06; 9(2). PMID: 24498287 Free PMC article.
Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance. Jason Miska, Midhat H Abdulreda, +5 authors, Zhibin Chen. less J Exp Med, 2014 Feb 26; 211(3). PMID: 24567447 Free PMC article.
The gut microbiota in mouse models of inflammatory bowel disease. Kalliopi K Gkouskou, Chrysoula Deligianni, Christos Tsatsanis, Aristides G Eliopoulos. Front Cell Infect Microbiol, 2014 Mar 13; 4. PMID: 24616886 Free PMC article. Review.
Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo. Linda C Sandin, Fredrik Eriksson, +3 authors, Sara M Mangsbo. less Oncoimmunology, 2014 Apr 05; 3(1). PMID: 24701377 Free PMC article.
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function. Kok-Fai Kong, Guo Fu, +10 authors, Amnon Altman. less Nat Immunol, 2014 Apr 08; 15(5). PMID: 24705298 Free PMC article. Highly Cited.
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs. Kesley Attridge, Lucy S K Walker. Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712457 Free PMC article. Review.
CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints--analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood. Babak Moradi, Philipp Schnatzer, +7 authors, Theresa Tretter. less Arthritis Res Ther, 2014 Apr 20; 16(2). PMID: 24742142 Free PMC article.
CD4⁺CD25⁻Foxp3⁺ T cells: a marker for lupus nephritis? Michael Bonelli, Lisa Göschl, +5 authors, Clemens Scheinecker. less Arthritis Res Ther, 2014 Apr 30; 16(2). PMID: 24774748 Free PMC article.
Bifidobacterium breve attenuates murine dextran sodium sulfate-induced colitis and increases regulatory T cell responses. Bin Zheng, Jeroen van Bergenhenegouwen, +6 authors, Aletta D Kraneveld. less PLoS One, 2014 May 03; 9(5). PMID: 24787575 Free PMC article.
Bacillus Calmette-Guérin Suppresses Asthmatic Responses via CD4(+)CD25(+) Regulatory T Cells and Dendritic Cells. Young-Joon Kim, Ha-Jung Kim, +6 authors, Soo-Jong Hong. less Allergy Asthma Immunol Res, 2014 May 21; 6(3). PMID: 24843794 Free PMC article.
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Edward Cha, Mark Klinger, +4 authors, Lawrence Fong. less Sci Transl Med, 2014 May 30; 6(238). PMID: 24871131 Free PMC article. Highly Cited.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1. Yi-Chi M Kong, Jeffrey C Flynn. Front Immunol, 2014 Jun 07; 5. PMID: 24904570 Free PMC article. Review.
Animal models of inflammatory bowel disease: a review. Nidhi Goyal, Ajay Rana, +2 authors, Puneet Kumar. less Inflammopharmacology, 2014 Jun 08; 22(4). PMID: 24906689 Review.
Helicobacter pylori infection and inflammatory bowel disease: is there a link? Konstantinos Papamichael, Panagiotis Konstantopoulos, Gerassimos J Mantzaris. World J Gastroenterol, 2014 Jun 11; 20(21). PMID: 24914359 Free PMC article. Review.
Antigen-Pulsed CpG-ODN-Activated Dendritic Cells Induce Host-Protective Immune Response by Regulating the T Regulatory Cell Functioning in Leishmania donovani-Infected Mice: Critical Role of CXCL10. Saikat Majumder, Amrita Bhattacharjee, +2 authors, Subrata Majumdar. less Front Immunol, 2014 Jun 14; 5. PMID: 24926293 Free PMC article.
Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles. Laura Esposito, Kara M D Hunter, +12 authors, Linda S Wicker. less J Immunol, 2014 Jun 15; 193(2). PMID: 24928993 Free PMC article.
The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts. Peter Urbanellis, Wendy Shyu, +12 authors, Andrzej Chruscinski. less Immunology, 2014 Jul 06; 144(1). PMID: 24990517 Free PMC article.
The alarmin IL-33 promotes regulatory T-cell function in the intestine. Chris Schiering, Thomas Krausgruber, +13 authors, Fiona Powrie. less Nature, 2014 Jul 22; 513(7519). PMID: 25043027 Free PMC article. Highly Cited.
Direct detection of FoxP3 expression in thymic double-negative CD4-CD8- cells by flow cytometry. Gang Liu, Zongfang Li, +3 authors, Yang Wei, Yan Lin, Cengceng Yang, Tie Liu. less Sci Rep, 2014 Jul 26; 4. PMID: 25060864 Free PMC article.
Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms. Daniel S Shin, Ayana Jordan, +5 authors, Fernando Macian. less EMBO Rep, 2014 Jul 31; 15(9). PMID: 25074018 Free PMC article.
T helper subsets in allergic eye disease. Nancy J Reyes, Daniel R Saban. Curr Opin Allergy Clin Immunol, 2014 Aug 12; 14(5). PMID: 25111509 Free PMC article. Review.
Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8. Justin P Edwards, Angela M Thornton, Ethan M Shevach. J Immunol, 2014 Aug 17; 193(6). PMID: 25127859 Free PMC article.
CD4+CD25hiCD127low regulatory T cells are increased in oral squamous cell carcinoma patients. Kue Peng Lim, Nicole Ai Leng Chun, +6 authors, Sok Ching Cheong. less PLoS One, 2014 Aug 26; 9(8). PMID: 25153698 Free PMC article.
TGFβ in T cell biology and tumor immunity: Angel or devil? Eric Tu, Pei Zhi Cheryl Chia, Wanjun Chen. Cytokine Growth Factor Rev, 2014 Aug 27; 25(4). PMID: 25156420 Free PMC article. Review.
Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke. Sheetal Bodhankar, Yingxin Chen, +3 authors, Halina Offner. less Front Cell Neurosci, 2014 Aug 27; 8. PMID: 25157219 Free PMC article.
Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy. Shirin Karimi, Subhasis Chattopadhyay, Nitya G Chakraborty. Immunology, 2014 Sep 23; 144(2). PMID: 25243729 Free PMC article. Review.
Tolerance in organ transplantation: from conventional immunosuppression to extracellular vesicles. Marta Monguió-Tortajada, Ricardo Lauzurica-Valdemoros, Francesc E Borràs. Front Immunol, 2014 Oct 04; 5. PMID: 25278936 Free PMC article. Review.
Targeting CD8+ T-cell tolerance for cancer immunotherapy. Stephanie R Jackson, Jinyun Yuan, Ryan M Teague. Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416 Free PMC article. Review.
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Desirée Schubert, Claudia Bode, +37 authors, Bodo Grimbacher. less Nat Med, 2014 Oct 21; 20(12). PMID: 25329329 Free PMC article. Highly Cited.
Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses. S M Krummey, M L Ford. Am J Transplant, 2014 Nov 13; 14(12). PMID: 25387592 Free PMC article. Review.
Anti-TNF-alpha loss of response is associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with Crohn's disease. Oriol Juanola, Alba Moratalla, +8 authors, Rubén Francés. less J Gastroenterol, 2014 Dec 17; 50(7). PMID: 25500977
Clinical blockade of PD1 and LAG3--potential mechanisms of action. Linh T Nguyen, Pamela S Ohashi. Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622 Highly Cited. Review.
Confusing signals: recent progress in CTLA-4 biology. Lucy S K Walker, David M Sansom. Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039 Free PMC article. Highly Cited. Review.
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Dalil Hannani, Marie Vétizou, +30 authors, Laurence Zitvogel. less Cell Res, 2015 Jan 15; 25(2). PMID: 25582080 Free PMC article. Highly Cited.
T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis. Rhoanne C McPherson, Darryl G Turner, +2 authors, Iris Mair, Richard A O'Connor, Stephen M Anderton. less Front Immunol, 2015 Mar 06; 6. PMID: 25741342 Free PMC article.
N-3-(oxododecanoyl)-L-homoserine lactone promotes the induction of regulatory T-cells by preventing human dendritic cell maturation. Youqiang Li, Huayou Zhou, +7 authors, Jianping Liu. less Exp Biol Med (Maywood), 2015 Mar 10; 240(7). PMID: 25749498 Free PMC article.
Harnessing regulatory T cells for the treatment of inflammatory bowel disease. Duke Geem, Akihito Harusato, Kyle Flannigan, Timothy L Denning. Inflamm Bowel Dis, 2015 Mar 21; 21(6). PMID: 25793328 Free PMC article. Review.
Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults. Steven A Yukl, Amandeep K Shergill, +10 authors, Joseph K Wong. less PLoS One, 2015 Mar 27; 10(3). PMID: 25811360 Free PMC article.
Korean Red Ginseng and Ginsenoside-Rb1/-Rg1 Alleviate Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells and Upregulating Regulatory T Cells. Min Jung Lee, Minhee Jang, +9 authors, Ik-Hyun Cho. less Mol Neurobiol, 2015 Apr 08; 53(3). PMID: 25846819
iPSC-MSCs Combined with Low-Dose Rapamycin Induced Islet Allograft Tolerance Through Suppressing Th1 and Enhancing Regulatory T-Cell Differentiation. Pan-Pan Cheng, Xiao-Cun Liu, +13 authors, Zhong-Quan Qi. less Stem Cells Dev, 2015 Apr 14; 24(15). PMID: 25867817 Free PMC article.
Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+ CD45RB high T Cells into Immunodeficient Mice. Erin C Steinbach, Gregory R Gipson, Shehzad Z Sheikh. J Vis Exp, 2015 May 06; (98). PMID: 25938395 Free PMC article.
Experimental Models of Inflammatory Bowel Diseases. Patricia Kiesler, Ivan J Fuss, Warren Strober. Cell Mol Gastroenterol Hepatol, 2015 May 23; 1(2). PMID: 26000334 Free PMC article. Highly Cited.
An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy. J-S Do, A Visperas, +10 authors, B Min. less Mucosal Immunol, 2015 May 28; 9(1). PMID: 26013006 Free PMC article.
Resident bacteria-stimulated IL-10-secreting B cells ameliorate T cell-mediated colitis by inducing Tr-1 cells that require IL-27-signaling. Yoshiyuki Mishima, Bo Liu, Jonathan J Hansen, R Balfour Sartor. Cell Mol Gastroenterol Hepatol, 2015 Jun 03; 1(3). PMID: 26034781 Free PMC article.
In-situ tumor vaccination: Bringing the fight to the tumor. Robert H Pierce, Jean S Campbell, +2 authors, Sara I Pai, Joshua D Brody, Holbrook E K Kohrt. less Hum Vaccin Immunother, 2015 Jun 10; 11(8). PMID: 26055074 Free PMC article. Review.
T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it? Florian Anzengruber, Pinar Avci, Lucas Freitas de Freitas, Michael R Hamblin. Photochem Photobiol Sci, 2015 Jun 13; 14(8). PMID: 26062987 Free PMC article.
Combination of Id2 Knockdown Whole Tumor Cells and Checkpoint Blockade: A Potent Vaccine Strategy in a Mouse Neuroblastoma Model. Lina Chakrabarti, Clifford Morgan, Anthony D Sandler. PLoS One, 2015 Jun 17; 10(6). PMID: 26079374 Free PMC article.
The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression. Alfred P See, Jonathon J Parker, Allen Waziri. J Neurooncol, 2015 Jul 01; 123(3). PMID: 26123363 Review.
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. Louisa E Jeffery, Omar S Qureshi, +6 authors, David M Sansom. less PLoS One, 2015 Jul 03; 10(7). PMID: 26134669 Free PMC article.
Different aspects of CD4 T cells that lead to viral clearance or persistence of HCV infection. Kazushi Sugimoto, Katsuya Shiraki. Hepatol Int, 2012 Jan 01; 6(1). PMID: 26201340
Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective. Masahiro Ono, Reiko J Tanaka. Immunol Cell Biol, 2015 Jul 29; 94(1). PMID: 26215792 Free PMC article.
Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells. Danielle Califano, Jonathan J Cho, +5 authors, Dorina Avram. less Immunity, 2015 Aug 02; 43(2). PMID: 26231117 Free PMC article. Highly Cited.
Immunomodulation of host-protective immune response by regulating Foxp3 expression and Treg function in Leishmania-infected BALB/c mice: critical role of IRF1. Bidisha Paul Chowdhury, Shibali Das, +5 authors, Subrata Majumdar. less Pathog Dis, 2015 Aug 25; 73(8). PMID: 26297915 Free PMC article.
Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease. James D Lord, Donna M Shows, Janice Chen, Richard C Thirlby. PLoS One, 2015 Aug 26; 10(8). PMID: 26305224 Free PMC article.
Huangqin-Tang Ameliorates TNBS-Induced Colitis by Regulating Effector and Regulatory CD4(+) T Cells. Ying Zou, Wen-Yang Li, +10 authors, Xue-Bao Zheng. less Biomed Res Int, 2015 Sep 09; 2015. PMID: 26347453 Free PMC article.
Immunosuppression associated with chronic inflammation in the tumor microenvironment. Dingzhi Wang, Raymond N DuBois. Carcinogenesis, 2015 Sep 12; 36(10). PMID: 26354776 Free PMC article. Highly Cited. Review.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. Alison M Paterson, Scott B Lovitch, +9 authors, Arlene H Sharpe. less J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185 Free PMC article. Highly Cited.
Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation. Niloufar Safinia, Cristiano Scotta, +2 authors, Giovanna Lombardi. less Front Immunol, 2015 Sep 18; 6. PMID: 26379673 Free PMC article. Review.
Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. Elisabeth R Mari, Jason N Moore, Guang-Xian Zhang, Abdolmohamad Rostami. Clin Exp Neuroimmunol, 2015 Oct 02; 6(3). PMID: 26425145 Free PMC article.
Ovarian carcinoma-infiltrating regulatory T cells were more potent suppressors of CD8(+) T cell inflammation than their peripheral counterparts, a function dependent on TIM3 expression. Meimei Bu, Yizhen Shen, +4 authors, Yan Cai. less Tumour Biol, 2015 Oct 21; 37(3). PMID: 26482613
Promises and paradoxes of regulatory T cells in inflammatory bowel disease. James D Lord. World J Gastroenterol, 2015 Nov 03; 21(40). PMID: 26523099 Free PMC article. Review.
Regulatory T cells in cardiovascular diseases. Xiao Meng, Jianmin Yang, +6 authors, Yun Zhang. less Nat Rev Cardiol, 2015 Nov 04; 13(3). PMID: 26525543 Highly Cited. Review.
Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells. Toshiharu Onodera, Atsunori Fukuhara, +6 authors, Iichiro Shimomura. less Sci Rep, 2015 Nov 20; 5. PMID: 26582486 Free PMC article.
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation. Gabriela Tejón, Valeria Manríquez, +8 authors, Mario Rosemblatt. less Biomed Res Int, 2015 Nov 20; 2015. PMID: 26583087 Free PMC article.
Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Peter Savas, Roberto Salgado, +4 authors, Sherene Loi. less Nat Rev Clin Oncol, 2015 Dec 17; 13(4). PMID: 26667975 Highly Cited. Review.
Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation. Niloufar Safinia, Trishan Vaikunthanathan, +9 authors, Giovanna Lombardi. less Oncotarget, 2016 Jan 21; 7(7). PMID: 26788992 Free PMC article. Highly Cited.
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases. Christophe Pedros, Fanny Duguet, Abdelhadi Saoudi, Marianne Chabod. World J Gastroenterol, 2016 Jan 27; 22(3). PMID: 26811641 Free PMC article. Review.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella. Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028 Free PMC article. Review.
Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition. Joanna Brzostek, Nicholas R J Gascoigne, Vasily Rybakin. Front Immunol, 2016 Feb 13; 7. PMID: 26870040 Free PMC article. Review.
Ipilimumab (Anti-Ctla-4 Mab) in the treatment of metastatic melanoma: Effectiveness and toxicity management. Paola Savoia, Chiara Astrua, Paolo Fava. Hum Vaccin Immunother, 2016 Feb 19; 12(5). PMID: 26889818 Free PMC article. Review.
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton. less Science, 2016 Mar 05; 351(6280). PMID: 26940869 Free PMC article. Highly Cited.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok. Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780 Free PMC article. Highly Cited. Review.
Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7. Matthew M Halpert, Vanaja Konduri, +5 authors, William K Decker. less Stem Cells Dev, 2016 Mar 17; 25(10). PMID: 26979751 Free PMC article.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas. Daniel E Lowther, Brittany A Goods, +10 authors, David A Hafler. less JCI Insight, 2016 May 18; 1(5). PMID: 27182555 Free PMC article. Highly Cited.
T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine. Thomas Krausgruber, Chris Schiering, +7 authors, Fiona Powrie. less Nat Commun, 2016 May 20; 7. PMID: 27193261 Free PMC article.
Monoclonal regulatory T cells provide insights into T cell suppression. Céline Gubser, Mathias Schmaler, Simona W Rossi, Ed Palmer. Sci Rep, 2016 May 24; 6. PMID: 27210828 Free PMC article.
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node. Hristina Nedelkovska, Alexander F Rosenberg, +9 authors, Steven H Bernstein. less PLoS One, 2016 May 27; 11(5). PMID: 27228053 Free PMC article.
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression. Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion. Front Immunol, 2016 Jun 01; 7. PMID: 27242797 Free PMC article. Review.
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions. Xin Li, Nicole V Acuff, +4 authors, Wendy T Watford. less J Biol Chem, 2016 Jun 05; 291(32). PMID: 27261457 Free PMC article.
Phenotypic and functional testing of circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab. Janet Retseck, Robert VanderWeele, +3 authors, Ahmad A Tarhini. less J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330811 Free PMC article.
Vagotomy affects the development of oral tolerance and increases susceptibility to develop colitis independently of the alpha-7 nicotinic receptor. Martina Di Giovangiulio, Goele Bosmans, +6 authors, Guy E Boeckxstaens. less Mol Med, 2016 Jun 25; 22. PMID: 27341335 Free PMC article.
Engagement of distinct epitopes on CD43 induces different co-stimulatory pathways in human T cells. Madhura Modak, Otto Majdic, +7 authors, Johannes Stöckl. less Immunology, 2016 Jul 09; 149(3). PMID: 27392084 Free PMC article.
CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency. Bernice Lo, Jill M Fritz, +3 authors, Michael J Lenardo. less Blood, 2016 Jul 16; 128(8). PMID: 27418640 Free PMC article. Review.
Regulatory T Cells: Central Concepts from Ontogeny to Therapy. Bernard Khor. Transfus Med Rev, 2016 Aug 16; 31(1). PMID: 27523957 Free PMC article. Review.
Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviate Intestinal Inflammation in Vivo. Tzu-Yu Shao, Ling-Hui Hsu, Chien-Hui Chien, Bor-Luen Chiang. Sci Rep, 2016 Sep 02; 6. PMID: 27581189 Free PMC article.
Regulatory T cells in allergic diseases. Magali Noval Rivas, Talal A Chatila. J Allergy Clin Immunol, 2016 Sep 07; 138(3). PMID: 27596705 Free PMC article. Highly Cited. Review.
Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis. Yin Zongyi, Chen Dongying, Li Baifeng. PLoS One, 2016 Sep 10; 11(9). PMID: 27611317 Free PMC article.
Restoring Regulatory T Cells in Type 1 Diabetes. Allyson Spence, Qizhi Tang. Curr Diab Rep, 2016 Sep 25; 16(11). PMID: 27664043 Review.
An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy. Chie Miyabe, Yoshishige Miyabe, +4 authors, Sebastian Unizony. less Ann Rheum Dis, 2016 Dec 09; 76(5). PMID: 27927642 Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors. Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim. Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545 Free PMC article. Review.
CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway. Pablo Penaloza-MacMaster. Immunology, 2017 Apr 05; 151(2). PMID: 28375543 Free PMC article. Review.
The Protective Role of Type I Interferons in the Gastrointestinal Tract. Kevin P Kotredes, Brianna Thomas, Ana M Gamero. Front Immunol, 2017 Apr 22; 8. PMID: 28428788 Free PMC article. Review.
Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction. Toshiki Eri, Kimito Kawahata, +10 authors, Kazuhiko Yamamoto. less Sci Rep, 2017 Apr 27; 7. PMID: 28443628 Free PMC article.
Dinitrophenyl hapten with laser immunotherapy for advanced malignant melanoma: A clinical study. Dian-Jun Chen, Xiao-Song Li, +8 authors, Wei-R Chen. less Oncol Lett, 2017 Apr 30; 13(3). PMID: 28454272 Free PMC article.
Ceramide synthesis regulates T cell activity and GVHD development. M Hanief Sofi, Jessica Heinrichs, +14 authors, Xue-Zhong Yu. less JCI Insight, 2017 May 19; 2(10). PMID: 28515365 Free PMC article.
Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity. Rebecca L Crepeau, Mandy L Ford. Expert Opin Biol Ther, 2017 May 21; 17(8). PMID: 28525959 Free PMC article. Review.
Rituximab in Minimal Change Disease: Mechanisms of Action and Hypotheses for Future Studies. Nima Madanchi, Martin Bitzan, Tomoko Takano. Can J Kidney Health Dis, 2017 May 26; 4. PMID: 28540057 Free PMC article. Review.
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Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function. Alexandre Bignon, Alan P Watt, Michelle A Linterman. Front Immunol, 2017 May 31; 8. PMID: 28555139 Free PMC article.
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Genetic Variants Assessing Crohn's Disease Pattern in Pediatric Inflammatory Bowel Disease Patients by a Clinical Exome Survey. Dago Dougba Noel, Pinelli Marinella, +9 authors, Badolato Raffaele. less Bioinform Biol Insights, 2022 Jan 11; 15. PMID: 35002226 Free PMC article.
The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation. Lisa Sandner, Marlis Alteneder, +11 authors, Nicole Boucheron. less Front Immunol, 2022 Jan 11; 12. PMID: 35003062 Free PMC article.
Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects. Shahrokh Abdolahi, Maryam Hosseini, +8 authors, Kaveh Baghaei. less Infect Genet Evol, 2022 Jan 10; 98. PMID: 34999004 Free PMC article.
Ethanol Intoxication and Burn Injury Increases Intestinal Regulatory T Cell Population and Regulatory T Cell Suppressive Capability. Marisa E Luck, Xiaoling Li, Caroline J Herrnreiter, Mashkoor A Choudhry. Shock, 2021 Sep 06; 57(2). PMID: 34482318 Free PMC article.
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients. Yifan Hu, Youdong Chen, +9 authors, Yuling Shi. less Front Cell Dev Biol, 2022 Feb 22; 9. PMID: 35186952 Free PMC article.
Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway. Mukesh K Sriwastva, Zhong-Bin Deng, +14 authors, Huang-Ge Zhang. less EMBO Rep, 2022 Jan 08; 23(3). PMID: 34994476 Free PMC article.
Key Players of the Immunosuppressive Tumor Microenvironment and Emerging Therapeutic Strategies. Kevin Park, Mysore S Veena, Daniel Sanghoon Shin. Front Cell Dev Biol, 2022 Mar 30; 10. PMID: 35345849 Free PMC article. Review.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis. Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom. Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201 Review.
Immune checkpoint inhibitors for the treatment of melanoma. Francesco Sabbatino, Luigi Liguori, Stefano Pepe, Soldano Ferrone. Expert Opin Biol Ther, 2022 Feb 09; 22(5). PMID: 35130816 Free PMC article. Review.
Pregnancy and Tumour: The Parallels and Differences in Regulatory T Cells. Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal. Front Immunol, 2022 May 03; 13. PMID: 35493450 Free PMC article. Review.
Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease. Sara Bolivar-Wagers, Jemma H Larson, Sujeong Jin, Bruce R Blazar. Front Immunol, 2022 May 03; 13. PMID: 35493508 Free PMC article. Review.
Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients. Emma J West, Karen J Scott, +11 authors, Adel Samson. less Cancers (Basel), 2022 May 15; 14(9). PMID: 35565310 Free PMC article.
Moving to the Outskirts: Interplay Between Regulatory T Cells and Peripheral Tissues. Anna Estrada Brull, Camilla Panetti, Nicole Joller. Front Immunol, 2022 May 17; 13. PMID: 35572535 Free PMC article. Review.
LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism. Raki Sudan, Sandra Fernandes, +5 authors, William G Kerr. less Front Immunol, 2022 May 24; 13. PMID: 35603158 Free PMC article.
The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Di Wu, Haomin Li, +2 authors, Mingwei Liu, Jun Qin, Yi Sun. less Nat Commun, 2022 Jun 01; 13(1). PMID: 35641500

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