Journal Article
. 2000 Jul; 192(2):295-302.
doi: 10.1084/jem.192.2.295.

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

S Read 1 V Malmström  F Powrie  
Affiliations
  • PMID: 10899916
  •     46 References
  •     658 citations

Abstract

It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both self- and intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same phenotype (CD25(+)CD45RB(low)CD4(+)) as those that control autoimmunity. Previous studies have failed to identify how CD25(+) Treg cells function in vivo. Our studies reveal that the immune-suppressive function of these cells in vivo is dependent on signaling via the negative regulator of T cell activation cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), as well as secretion of the immune-suppressive cytokine transforming growth factor beta. Strikingly, constitutive expression of CTLA-4 among CD4(+) cells was restricted primarily to Treg cells, suggesting that CTLA-4 expression by these cells is involved in their immune-suppressive function. These findings raise the possibility that Treg cell function contributes to the immune suppression characteristic of CTLA-4 signaling. Identification of costimulatory molecules involved in the function of Treg cells may facilitate further characterization of these cells and development of new therapeutic strategies for the treatment of inflammatory diseases.

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Regulatory functions of CD8+CD28- T cells in an autoimmune disease model.
Nader Najafian, Tanuja Chitnis, +6 authors, Samia J Khoury.
J Clin Invest, 2003 Oct 03; 112(7). PMID: 14523041    Free PMC article.
Changes of CD8+CD28- T regulatory cells in rat model of colitis induced by 2,4-dinitrofluorobenzene.
Wen-Bin Xiao, Yu-Lan Liu.
World J Gastroenterol, 2003 Nov 08; 9(11). PMID: 14606090    Free PMC article.
Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases.
Marie-Alexandra Alyanakian, Sylvaine You, +6 authors, Jean-François Bach.
Proc Natl Acad Sci U S A, 2003 Dec 16; 100(26). PMID: 14673094    Free PMC article.
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
WanJun Chen, Wenwen Jin, +5 authors, Sharon M Wahl.
J Exp Med, 2003 Dec 17; 198(12). PMID: 14676299    Free PMC article.
Highly Cited.
CTLA-4 blockade inhibits induction of Helicobacter pylori-associated gastritis in mice.
K Watanabe, K Murakami, +5 authors, T Fujioka.
Clin Exp Immunol, 2003 Dec 18; 135(1). PMID: 14678261    Free PMC article.
TGF-beta: how tolerant can it be?
Sharon M Wahl, Wanjun Chen.
Immunol Res, 2004 Jan 10; 28(3). PMID: 14713712
Review.
Antibody-induced transplantation tolerance: the role of dominant regulation.
Luis Graca, Alain Le Moine, Stephen P Cobbold, Herman Waldmann.
Immunol Res, 2004 Jan 10; 28(3). PMID: 14713713
Review.
Oral tolerance.
Henry Yim Wu, Howard L Weiner.
Immunol Res, 2004 Jan 10; 28(3). PMID: 14713719
Review.
A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses.
Zoltán Fehérvári, Shimon Sakaguchi.
Arthritis Res Ther, 2004 Feb 26; 6(1). PMID: 14979928    Free PMC article.
The concept of space and competition in immune regulation.
Brigitta Stockinger, Thomas Barthlott, George Kassiotis.
Immunology, 2004 Mar 11; 111(3). PMID: 15009422    Free PMC article.
Review.
Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen.
Masako Kohyama, Daisuke Sugahara, +3 authors, Nobumichi Hozumi.
Proc Natl Acad Sci U S A, 2004 Mar 12; 101(12). PMID: 15014176    Free PMC article.
CD4+ CD25+ Treg: divide and rule?
Lucy S K Walker.
Immunology, 2004 Mar 19; 111(2). PMID: 15027897    Free PMC article.
Review.
Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases.
Monika C Brunner-Weinzierl, Holger Hoff, Gerd-R Burmester.
Arthritis Res Ther, 2004 Apr 03; 6(2). PMID: 15059264    Free PMC article.
Review.
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis.
Vissia Viglietta, Clare Baecher-Allan, Howard L Weiner, David A Hafler.
J Exp Med, 2004 Apr 07; 199(7). PMID: 15067033    Free PMC article.
Highly Cited.
Maintenance of remission in Crohn's disease: current and emerging therapeutic options.
Matthew J Brookes, Jonathon R B Green.
Drugs, 2004 May 14; 64(10). PMID: 15139787
Review.
Differential expression of CTLA-4 among T cell subsets.
C B Jago, J Yates, +2 authors, G Lombardi.
Clin Exp Immunol, 2004 May 19; 136(3). PMID: 15147348    Free PMC article.
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.
Mübeccel Akdis, Johan Verhagen, +12 authors, Cezmi A Akdis.
J Exp Med, 2004 Jun 03; 199(11). PMID: 15173208    Free PMC article.
Highly Cited.
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
Qizhi Tang, Kammi J Henriksen, +7 authors, Jeffrey A Bluestone.
J Exp Med, 2004 Jun 09; 199(11). PMID: 15184499    Free PMC article.
Highly Cited.
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion.
Ann E Herman, Gordon J Freeman, Diane Mathis, Christophe Benoist.
J Exp Med, 2004 Jun 09; 199(11). PMID: 15184501    Free PMC article.
Highly Cited.
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes.
Catrin M McGregor, Stephen P Schoenberger, E Allison Green.
Proc Natl Acad Sci U S A, 2004 Jun 12; 101(25). PMID: 15192149    Free PMC article.
Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy.
Malin R Karlsson, Jarle Rugtveit, Per Brandtzaeg.
J Exp Med, 2004 Jun 16; 199(12). PMID: 15197226    Free PMC article.
Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen.
Mark P Eggena, Lucy S K Walker, +3 authors, Abul K Abbas.
J Exp Med, 2004 Jun 24; 199(12). PMID: 15210748    Free PMC article.
CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease.
Duojia Cao, Ronald van Vollenhoven, +2 authors, Vivianne Malmström.
Arthritis Res Ther, 2004 Jul 01; 6(4). PMID: 15225369    Free PMC article.
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells.
Kyra Oswald-Richter, Stacy M Grill, +4 authors, Derya Unutmaz.
PLoS Biol, 2004 Jul 15; 2(7). PMID: 15252446    Free PMC article.
Highly Cited.
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy.
Michael R Ehrenstein, Jamie G Evans, +4 authors, Claudia Mauri.
J Exp Med, 2004 Jul 29; 200(3). PMID: 15280421    Free PMC article.
Highly Cited.
Suppressor T cells in human diseases.
Clare Baecher-Allan, David A Hafler.
J Exp Med, 2004 Jul 29; 200(3). PMID: 15280423    Free PMC article.
Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells.
Helene C Dujardin, Odile Burlen-Defranoux, +3 authors, Antonio Bandeira.
Proc Natl Acad Sci U S A, 2004 Sep 29; 101(40). PMID: 15452347    Free PMC article.
CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis.
Taeko Dohi, Kohtaro Fujihashi, +4 authors, Jerry R McGhee.
Am J Pathol, 2004 Oct 07; 165(4). PMID: 15466391    Free PMC article.
CD4+ Tregs and immune control.
Zoltán Fehérvari, Shimon Sakaguchi.
J Clin Invest, 2004 Nov 03; 114(9). PMID: 15520849    Free PMC article.
Highly Cited. Review.
Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody.
Dean T Nardelli, Matthew A Burchill, +3 authors, Ronald F Schell.
Clin Diagn Lab Immunol, 2004 Nov 13; 11(6). PMID: 15539509    Free PMC article.
IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage.
Anne O'Garra, Pedro L Vieira, Paulo Vieira, Anne E Goldfeld.
J Clin Invest, 2004 Nov 17; 114(10). PMID: 15545984    Free PMC article.
Highly Cited. Review.
Tregs and allergic disease.
Douglas S Robinson, Mark Larché, Stephen R Durham.
J Clin Invest, 2004 Nov 17; 114(10). PMID: 15545986    Free PMC article.
Review.
Characterization of T-regulatory cells, induced by immature dendritic cells, which inhibit enteroantigen-reactive colitis-inducing T-cell responses in vitro and in vivo.
Monika Gad, Nanna N Kristensen, Evelyn Kury, Mogens H Claesson.
Immunology, 2004 Nov 24; 113(4). PMID: 15554928    Free PMC article.
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Hyung W Lim, Peter Hillsamer, Chang H Kim.
J Clin Invest, 2004 Dec 04; 114(11). PMID: 15578096    Free PMC article.
Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation.
Hideaki Sugiyama, Rolland Gyulai, +5 authors, Kevin D Cooper.
J Immunol, 2004 Dec 22; 174(1). PMID: 15611238    Free PMC article.
Highly Cited.
Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus.
Shuang Liang, Pascale Alard, +3 authors, Michele M Kosiewicz.
J Exp Med, 2005 Jan 05; 201(1). PMID: 15630140    Free PMC article.
Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGepsilon26 mice leading to the prevention of colitis.
C Veltkamp, R B Sartor, +6 authors, W Stremmel.
Gut, 2005 Jan 14; 54(2). PMID: 15647183    Free PMC article.
Regulatory cells and the control of respiratory infection.
Peter McGuirk, Sarah C Higgins, Kingston H G Mills.
Curr Allergy Asthma Rep, 2005 Jan 22; 5(1). PMID: 15659263
Review.
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.
Roland Grenningloh, Bok Yun Kang, I-Cheng Ho.
J Exp Med, 2005 Feb 25; 201(4). PMID: 15728239    Free PMC article.
Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases.
Sharon M Wahl, Wanjun Chen.
Arthritis Res Ther, 2005 Mar 04; 7(2). PMID: 15743491    Free PMC article.
Review.
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
Linda Fahlén, Simon Read, +4 authors, Fiona Powrie.
J Exp Med, 2005 Mar 09; 201(5). PMID: 15753207    Free PMC article.
Highly Cited.
Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion.
Santiago Zelenay, Thiago Lopes-Carvalho, +3 authors, Jocelyne Demengeot.
Proc Natl Acad Sci U S A, 2005 Mar 09; 102(11). PMID: 15753306    Free PMC article.
A role for alphabeta T cells in the resistant phase of the Brown Norway rat model of vasculitis.
C S Vinen, D R Turner, D B G Oliveira.
Clin Exp Immunol, 2005 Mar 15; 140(1). PMID: 15762872    Free PMC article.
Down-regulation of epithelial IL-8 responses in Helicobacter pylori-infected duodenal ulcer patients depends on host factors, rather than bacterial factors.
E Strömberg, A Edebo, +4 authors, C Lindholm.
Clin Exp Immunol, 2005 Mar 15; 140(1). PMID: 15762883    Free PMC article.
CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis.
M Möttönen, J Heikkinen, +3 authors, O Lassila.
Clin Exp Immunol, 2005 Apr 06; 140(2). PMID: 15807863    Free PMC article.
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes.
Shannon M Pop, Carmen P Wong, +2 authors, Roland Tisch.
J Exp Med, 2005 Apr 20; 201(8). PMID: 15837817    Free PMC article.
Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease.
Yoshihisa Yamano, Norihiro Takenouchi, +5 authors, Steven Jacobson.
J Clin Invest, 2005 May 03; 115(5). PMID: 15864353    Free PMC article.
Multiple costimulatory modalities enhance CTL avidity.
James W Hodge, Mala Chakraborty, +2 authors, Jeffrey Schlom.
J Immunol, 2005 May 10; 174(10). PMID: 15879092    Free PMC article.
Regulatory T cells in rheumatoid arthritis.
Jan Leipe, Alla Skapenko, Peter E Lipsky, Hendrik Schulze-Koops.
Arthritis Res Ther, 2005 May 19; 7(3). PMID: 15899057    Free PMC article.
Review.
Oral tolerance in the absence of naturally occurring Tregs.
Daniel Mucida, Nino Kutchukhidze, +3 authors, Maria A Curotto de Lafaille.
J Clin Invest, 2005 Jun 07; 115(7). PMID: 15937545    Free PMC article.
Highly Cited.
CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection.
Dean T Nardelli, Joseph P Cloute, +4 authors, Ronald F Schell.
Clin Diagn Lab Immunol, 2005 Jun 09; 12(6). PMID: 15939755    Free PMC article.
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia.
Claudia R Ruprecht, Marco Gattorno, +4 authors, Federica Sallusto.
J Exp Med, 2005 Jun 09; 201(11). PMID: 15939793    Free PMC article.
Highly Cited.
Activated CD4+ CD25+ T cells suppress antigen-specific CD4+ and CD8+ T cells but induce a suppressive phenotype only in CD4+ T cells.
Detlef Dieckmann, Heidi Plöttner, Stefanie Dotterweich, Gerold Schuler.
Immunology, 2005 Jun 11; 115(3). PMID: 15946248    Free PMC article.
The role of mucosal T lymphocytes in regulating intestinal inflammation.
Holm H Uhlig, Fiona Powrie.
Springer Semin Immunopathol, 2005 Jun 17; 27(2). PMID: 15959782
Review.
Role of helminths in regulating mucosal inflammation.
Joel V Weinstock, Robert W Summers, David E Elliott.
Springer Semin Immunopathol, 2005 Jun 17; 27(2). PMID: 15959781
Review.
Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae.
Victoria Gillan, Eileen Devaney.
Infect Immun, 2005 Jun 24; 73(7). PMID: 15972491    Free PMC article.
A peripheral circulating compartment of natural naive CD4 Tregs.
Danila Valmori, Andrea Merlo, +2 authors, Maha Ayyoub.
J Clin Invest, 2005 Jul 12; 115(7). PMID: 16007258    Free PMC article.
Highly Cited.
Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells.
Badiga Venkata Aruna, Michael Sela, Edna Mozes.
Proc Natl Acad Sci U S A, 2005 Jul 15; 102(29). PMID: 16014414    Free PMC article.
FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease.
J Kelsen, J Agnholt, +3 authors, J F Dahlerup.
Clin Exp Immunol, 2005 Jul 28; 141(3). PMID: 16045746    Free PMC article.
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.
Niklas Beyersdorf, Stefanie Gaupp, +7 authors, Ralf Gold.
J Exp Med, 2005 Aug 03; 202(3). PMID: 16061730    Free PMC article.
The role of the FOXP3 transcription factor in the immune regulation of allergic asthma.
Carsten B Schmidt-Weber, Kurt Blaser.
Curr Allergy Asthma Rep, 2005 Aug 11; 5(5). PMID: 16091206
Review.
Function of tumor necrosis factor receptor family members on regulatory T-cells.
Robert H Arch.
Immunol Res, 2005 Aug 18; 32(1-3). PMID: 16106056
Review.
Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor.
Iris Bellinghausen, Bettina König, +2 authors, Joachim Saloga.
Immunology, 2005 Aug 20; 116(1). PMID: 16108822    Free PMC article.
Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
K Inagaki-Ohara, A Sasaki, +7 authors, A Yoshimura.
Gut, 2005 Aug 27; 55(2). PMID: 16120757    Free PMC article.
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
Helga Schneider, Elke Valk, +2 authors, Christopher E Rudd.
Proc Natl Acad Sci U S A, 2005 Aug 30; 102(36). PMID: 16126897    Free PMC article.
CD4+ regulatory cells as a potential immunotherapy.
Zoltán Fehérvari, Shimon Sakaguchi.
Philos Trans R Soc Lond B Biol Sci, 2005 Sep 09; 360(1461). PMID: 16147529    Free PMC article.
Review.
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.
Masayuki Sho, Koji Kishimoto, +8 authors, David M Rothstein.
Proc Natl Acad Sci U S A, 2005 Sep 10; 102(37). PMID: 16150717    Free PMC article.
Co-stimulatory blockade as therapy for rheumatoid arthritis.
Sarah L Mackie, Edward M Vital, Frederique Ponchel, Paul Emery.
Curr Rheumatol Rep, 2005 Sep 22; 7(5). PMID: 16174492
Review.
Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44.
Mihail Firan, Sohita Dhillon, Pila Estess, Mark H Siegelman.
Blood, 2005 Sep 24; 107(2). PMID: 16179372    Free PMC article.
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.
Kuibeom Ko, Sayuri Yamazaki, +7 authors, Shimon Sakaguchi.
J Exp Med, 2005 Sep 28; 202(7). PMID: 16186187    Free PMC article.
Highly Cited.
Essential role for CD103 in the T cell-mediated regulation of experimental colitis.
Oliver Annacker, Janine L Coombes, +6 authors, Fiona Powrie.
J Exp Med, 2005 Oct 12; 202(8). PMID: 16216886    Free PMC article.
Highly Cited.
Biologic therapy for inflammatory bowel disease.
Sandro Ardizzone, Gabriele Bianchi Porro.
Drugs, 2005 Nov 04; 65(16). PMID: 16266194
Review.
Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.
Begonia Ruiz-Perez, Doo R Chung, +5 authors, Arthur O Tzianabos.
Proc Natl Acad Sci U S A, 2005 Nov 09; 102(46). PMID: 16275921    Free PMC article.
Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes.
Roberto Mallone, Gerald T Nepom.
Am J Ther, 2005 Nov 11; 12(6). PMID: 16280647    Free PMC article.
Review.
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study.
Ajay V Maker, Giao Q Phan, +11 authors, Steven A Rosenberg.
Ann Surg Oncol, 2005 Nov 12; 12(12). PMID: 16283570    Free PMC article.
Highly Cited.
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade.
Ajay V Maker, Peter Attia, Steven A Rosenberg.
J Immunol, 2005 Nov 23; 175(11). PMID: 16301685    Free PMC article.
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Qizhi Tang, Jason Y Adams, +7 authors, Jeffrey A Bluestone.
Nat Immunol, 2005 Nov 29; 7(1). PMID: 16311599    Free PMC article.
Highly Cited.
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function.
Ian P Lewkowich, Nancy S Herman, +8 authors, Marsha Wills-Karp.
J Exp Med, 2005 Nov 30; 202(11). PMID: 16314437    Free PMC article.
Highly Cited.
Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.
Dirk Homann, Wolfgang Dummer, +4 authors, Matthias G von Herrath.
J Virol, 2005 Dec 15; 80(1). PMID: 16352552    Free PMC article.
Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells.
Elena Gonzalez-Rey, Alejo Chorny, +2 authors, Mario Delgado.
Blood, 2006 Jan 07; 107(9). PMID: 16397128    Free PMC article.
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma.
Zhi-Zhang Yang, Anne J Novak, +2 authors, Stephen M Ansell.
Blood, 2006 Jan 13; 107(9). PMID: 16403912    Free PMC article.
Highly Cited.
Involvement of 4-1BB (CD137)-4-1BBligand interaction in the modulation of CD4 T cell-mediated inflammatory colitis.
P Maerten, B S Kwon, +9 authors, J L Ceuppens.
Clin Exp Immunol, 2006 Jan 18; 143(2). PMID: 16412046    Free PMC article.
Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4(+) CD25(+) T cells of patients with inflammatory bowel disease.
Maho Ikeda, Fuminao Takeshima, +6 authors, Shigeru Kohno.
Dig Dis Sci, 2006 Jan 18; 51(1). PMID: 16416233
Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response.
Alejo Chorny, Elena Gonzalez-Rey, +2 authors, Mario Delgado.
Blood, 2006 Jan 19; 107(9). PMID: 16418327    Free PMC article.
Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus.
Jyh-Hong Lee, Li-Chieh Wang, +3 authors, Bor-Luen Chiang.
Immunology, 2006 Jan 21; 117(2). PMID: 16423064    Free PMC article.
The immune paradox of sarcoidosis and regulatory T cells.
Makoto Miyara, Zahir Amoura, +9 authors, Guy Gorochov.
J Exp Med, 2006 Jan 25; 203(2). PMID: 16432251    Free PMC article.
Highly Cited.
Selective roles and dysregulation of interleukin-10 in allergic disease.
Judith A Woodfolk.
Curr Allergy Asthma Rep, 2006 Feb 16; 6(1). PMID: 16476193
Review.
Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells.
Alison Taylor, Johan Verhagen, +2 authors, Cezmi A Akdis.
Immunology, 2006 Mar 25; 117(4). PMID: 16556256    Free PMC article.
Highly Cited. Review.
Total colectomy improves altered distribution of regulatory T cells in patients with ulcerative colitis.
Makoto Furihata, Tokihiko Sawada, +5 authors, Keiichi Kubota.
World J Surg, 2006 Mar 29; 30(4). PMID: 16568230
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.
Ichiko Kinjyo, Hiromasa Inoue, +8 authors, Akihiko Yoshimura.
J Exp Med, 2006 Apr 12; 203(4). PMID: 16606674    Free PMC article.
T regulatory cell suppression of colitis: the role of TGF-beta.
R Duchmann, M Zeitz.
Gut, 2006 Apr 13; 55(5). PMID: 16609133    Free PMC article.
An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.
Makoto Takahashi, Kazuhiko Nakamura, +7 authors, Hajime Nawata.
Dig Dis Sci, 2006 Apr 15; 51(4). PMID: 16614988
Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels.
F Bolacchi, A Sinistro, +6 authors, A Bergamini.
Clin Exp Immunol, 2006 Apr 26; 144(2). PMID: 16634790    Free PMC article.
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.
Kimberly E Beck, Joseph A Blansfield, +12 authors, James C Yang.
J Clin Oncol, 2006 May 20; 24(15). PMID: 16710025    Free PMC article.
Highly Cited.
CD4+ CD25+ regulatory T cells modulate the T-cell and antibody responses in helicobacter-infected BALB/c mice.
Maria Kaparakis, Karen L Laurie, +5 authors, Richard A Strugnell.
Infect Immun, 2006 May 23; 74(6). PMID: 16714584    Free PMC article.
Checkpoint blockade in cancer immunotherapy.
Alan J Korman, Karl S Peggs, James P Allison.
Adv Immunol, 2006 May 30; 90. PMID: 16730267    Free PMC article.
Highly Cited. Review.
The role of CD4 T cells in the pathogenesis of murine AIDS.
Wen Li, William R Green.
J Virol, 2006 May 30; 80(12). PMID: 16731917    Free PMC article.
Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma.
Machteld M Tiemessen, Tracey J Mitchell, +3 authors, Susan John.
J Invest Dermatol, 2006 Jun 03; 126(10). PMID: 16741512    Free PMC article.
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.
Cecilia Oderup, Lukas Cederbom, +2 authors, Fredrik Ivars.
Immunology, 2006 Jun 15; 118(2). PMID: 16771859    Free PMC article.
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells.
Sergio A Quezada, Karl S Peggs, Michael A Curran, James P Allison.
J Clin Invest, 2006 Jun 17; 116(7). PMID: 16778987    Free PMC article.
Highly Cited.
The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children.
C-O Jonson, M Hedman, +5 authors, ABIS Study Group.
Clin Exp Immunol, 2006 Jun 24; 145(1). PMID: 16792673    Free PMC article.
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.
Ajay V Maker, James C Yang, +11 authors, Steven A Rosenberg.
J Immunother, 2006 Jun 27; 29(4). PMID: 16799341    Free PMC article.
Signatures of human regulatory T cells: an encounter with old friends and new players.
Susanne Pfoertner, Andreas Jeron, +8 authors, Robert Geffers.
Genome Biol, 2006 Jul 14; 7(7). PMID: 16836768    Free PMC article.
Regulatory T cells in experimental autoimmune disease.
Elisabeth Suri-Payer, Benedikt Fritzsching.
Springer Semin Immunopathol, 2006 Jul 14; 28(1). PMID: 16838180
Review.
Costimulation couture: a designer approach to regulating autoimmunity.
Mohammed Javeed Ansari, Mohamed H Sayegh.
J Clin Invest, 2006 Aug 04; 116(8). PMID: 16886054    Free PMC article.
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
Brian T Fife, Matthew D Griffin, +2 authors, Jeffrey A Bluestone.
J Clin Invest, 2006 Aug 04; 116(8). PMID: 16886063    Free PMC article.
Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy.
Kirsty S Nicolson, David C Wraith.
Inflamm Allergy Drug Targets, 2006 Aug 22; 5(3). PMID: 16918477    Free PMC article.
Review.
Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule.
Henri Braat, Peter McGuirk, +5 authors, Kingston H G Mills.
Gut, 2006 Sep 06; 56(3). PMID: 16952913    Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer.
R Houston Thompson, James P Allison, Eugene D Kwon.
Urol Oncol, 2006 Sep 12; 24(5). PMID: 16962497    Free PMC article.
Review.
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Simon Read, Rebecca Greenwald, +5 authors, Fiona Powrie.
J Immunol, 2006 Sep 20; 177(7). PMID: 16982872    Free PMC article.
Highly Cited.
Cancer immunosuppression and autoimmune disease: beyond immunosuppressive networks for tumour immunity.
Ryungsa Kim, Manabu Emi, Kazuaki Tanabe.
Immunology, 2006 Sep 29; 119(2). PMID: 17005005    Free PMC article.
Review.
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
John J Zaunders, Susanna Ip, +15 authors, Anthony D Kelleher.
J Virol, 2006 Sep 29; 80(20). PMID: 17005693    Free PMC article.
Interleukin-23 drives innate and T cell-mediated intestinal inflammation.
Sophie Hue, Philip Ahern, +5 authors, Kevin J Maloy.
J Exp Med, 2006 Oct 13; 203(11). PMID: 17030949    Free PMC article.
Highly Cited.
Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities.
Masahisa Jinushi, Tetsuo Takehara, +6 authors, Norio Hayashi.
Immunology, 2006 Oct 21; 120(1). PMID: 17052247    Free PMC article.
Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis.
Holm H Uhlig, Janine Coombes, +7 authors, Fiona Powrie.
J Immunol, 2006 Oct 24; 177(9). PMID: 17056509    Free PMC article.
Highly Cited.
Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells.
Deborah H Strickland, Philip A Stumbles, +5 authors, Patrick G Holt.
J Exp Med, 2006 Nov 08; 203(12). PMID: 17088431    Free PMC article.
CD8 blockade promotes the expansion of antigen-specific CD4+ FOXP3+ regulatory T cells in vivo.
Z Wang, J D Davies.
Int Immunopharmacol, 2006 Dec 21; 7(2). PMID: 17178393    Free PMC article.
CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer.
Sarah L Clarke, Gareth J Betts, +8 authors, Andrew J Godkin.
PLoS One, 2007 Jan 06; 1. PMID: 17205133    Free PMC article.
The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells.
Michel H Maillard, Vinicius Cotta-de-Almeida, +5 authors, Scott B Snapper.
J Exp Med, 2007 Feb 14; 204(2). PMID: 17296786    Free PMC article.
CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis.
Catherine Q Nie, Nicholas J Bernard, Louis Schofield, Diana S Hansen.
Infect Immun, 2007 Feb 28; 75(5). PMID: 17325053    Free PMC article.
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease.
B Afzali, G Lombardi, R I Lechler, G M Lord.
Clin Exp Immunol, 2007 Mar 03; 148(1). PMID: 17328715    Free PMC article.
Highly Cited. Review.
The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma.
J-H Lee, H-H Yu, +3 authors, B-L Chiang.
Clin Exp Immunol, 2007 Mar 14; 148(1). PMID: 17349011    Free PMC article.
Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.
Khoon Lin Ling, Sarah E Pratap, +9 authors, Vincenzo Cerundolo.
Cancer Immun, 2007 Mar 29; 7. PMID: 17388261    Free PMC article.
Demonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis.
Yoko Yokoyama, Ken Fukunaga, +9 authors, Takayuki Matsumoto.
Dig Dis Sci, 2007 Apr 04; 52(10). PMID: 17404876
An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice.
David C Thomas, Richard J Mellanby, Jenny M Phillips, Anne Cooke.
Immunology, 2007 Apr 18; 121(4). PMID: 17437531    Free PMC article.
Regulatory cells and immunosuppressive cytokines: parasite-derived factors induce immune polarization.
Ali Ouaissi.
J Biomed Biotechnol, 2007 Jun 29; 2007(4). PMID: 17597838    Free PMC article.
Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection.
Ellen Marks, Martina Verolin, Anneli Stensson, Nils Lycke.
Infect Immun, 2007 Jul 20; 75(9). PMID: 17635872    Free PMC article.
CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion.
Anders E Pedersen, Franca Ronchese.
J Immune Based Ther Vaccines, 2007 Jul 31; 5. PMID: 17662155    Free PMC article.
Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice.
L-Y Khil, H-S Jun, +4 authors, J-W Yoon.
Diabetologia, 2007 Aug 07; 50(10). PMID: 17676307
Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.
Sayuri Yamazaki, Anthony J Bonito, +3 authors, Ralph M Steinman.
Blood, 2007 Aug 19; 110(13). PMID: 17699744    Free PMC article.
Transplantation tolerance: lessons from experimental rodent models.
Cherry I Kingsley, Satish N Nadig, Kathryn J Wood.
Transpl Int, 2007 Aug 23; 20(10). PMID: 17711408    Free PMC article.
Review.
Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection.
Guoping Peng, Shuping Li, +3 authors, Zhi Chen.
Immunology, 2007 Sep 04; 123(1). PMID: 17764450    Free PMC article.
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.
Heather M Gibson, Carrie J Hedgcock, +4 authors, Henry K Wong.
J Immunol, 2007 Sep 06; 179(6). PMID: 17785820    Free PMC article.
Regulatory T cells in viral hepatitis.
Eva Billerbeck, Tobias Bottler, Robert Thimme.
World J Gastroenterol, 2007 Sep 11; 13(36). PMID: 17828817    Free PMC article.
Review.
Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection.
Amanda J Chase, Ahmad R Sedaghat, +4 authors, Robert F Siliciano.
J Virol, 2007 Sep 15; 81(23). PMID: 17855517    Free PMC article.
FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load.
Ingrid Karlsson, Benoît Malleret, +4 authors, Bruno Vaslin.
J Virol, 2007 Sep 28; 81(24). PMID: 17898053    Free PMC article.
Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression.
Elizabeth H Field, Katarina Kulhankova, Mohamed E Nasr.
Immunol Res, 2007 Oct 06; 39(1-3). PMID: 17917056
Resistance to apoptosis and expansion of regulatory T cells in relation to the detection of circulating tumor cells in patients with metastatic epithelial cancer.
Stefanie Stanzer, Nadia Dandachi, +3 authors, Thomas Bauernhofer.
J Clin Immunol, 2007 Oct 17; 28(2). PMID: 17939021
Advancements in immune tolerance.
Ping-Ying Pan, Junko Ozao, Zuping Zhou, Shu-Hsia Chen.
Adv Drug Deliv Rev, 2007 Nov 03; 60(2). PMID: 17976856    Free PMC article.
Review.
Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.
Jane E Willoughby, Patrick S Costello, +4 authors, Richard Treisman.
J Immunol, 2007 Nov 06; 179(10). PMID: 17982074    Free PMC article.
The role of CTLA-4 in immune regulation.
Johan Verhagen, Catherine A Sabatos, David C Wraith.
Immunol Lett, 2007 Nov 24; 115(1). PMID: 18035425    Free PMC article.
Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.
Ana Izcue, Fiona Powrie.
Immunology, 2007 Dec 25; 123(1). PMID: 18154611    Free PMC article.
Review.
Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis.
Shailesh R Satpute, Malarvizhi Durai, Kamal D Moudgil.
Semin Arthritis Rheum, 2008 Jan 08; 38(3). PMID: 18177689    Free PMC article.
Review.
Pathogen induced regulatory cell populations preventing allergy through the Th1/Th2 paradigm point of view.
Thomas Roumier, Monique Capron, David Dombrowicz, Christelle Faveeuw.
Immunol Res, 2008 Jan 15; 40(1). PMID: 18193360
Review.
Immune function abnormalities in peripheral blood mononuclear cell cytokine expression differentiates stages of cutaneous T-cell lymphoma/mycosis fungoides.
Benjamin F Chong, Adam J Wilson, +4 authors, Henry K Wong.
Clin Cancer Res, 2008 Feb 05; 14(3). PMID: 18245523    Free PMC article.
Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease?
Esaki Muthu Shankar, Ramachandran Vignesh, +7 authors, Nagalingeswaran Kumarasamy.
J Inflamm (Lond), 2008 Feb 20; 5. PMID: 18282273    Free PMC article.
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.
F Stephen Hodi, Marcus Butler, +17 authors, Glenn Dranoff.
Proc Natl Acad Sci U S A, 2008 Feb 22; 105(8). PMID: 18287062    Free PMC article.
Highly Cited.
Lentivirus-induced immune dysregulation.
Mary B Tompkins, Wayne A Tompkins.
Vet Immunol Immunopathol, 2008 Feb 22; 123(1-2). PMID: 18289702    Free PMC article.
Review.
Comparative methodologies of regulatory T cell depletion in a murine melanoma model.
Norimasa Matsushita, Shari A Pilon-Thomas, Lisa M Martin, Adam I Riker.
J Immunol Methods, 2008 Feb 26; 333(1-2). PMID: 18295790    Free PMC article.
Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression.
Panayotis Verginis, Katherine A McLaughlin, +2 authors, Irina Apostolou.
Proc Natl Acad Sci U S A, 2008 Feb 27; 105(9). PMID: 18299571    Free PMC article.
Regulatory T cells and human disease.
Nathalie Cools, Peter Ponsaerts, Viggo F I Van Tendeloo, Zwi N Berneman.
Clin Dev Immunol, 2008 Mar 05; 2007. PMID: 18317534    Free PMC article.
Review.
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target.
Dorothy K Sojka, Yu-Hui Huang, Deborah J Fowell.
Immunology, 2008 Mar 19; 124(1). PMID: 18346152    Free PMC article.
Review.
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.
Ana Izcue, Sophie Hue, +5 authors, Fiona Powrie.
Immunity, 2008 Apr 11; 28(4). PMID: 18400195    Free PMC article.
Highly Cited.
Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis.
Christy Toms, Heidi Jessup, +3 authors, Fiona Powrie.
Immunology, 2008 May 16; 125(3). PMID: 18479351    Free PMC article.
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Mei-Ling Chen, Bo-Shiun Yan, +2 authors, Howard L Weiner.
J Immunol, 2008 May 21; 180(11). PMID: 18490732    Free PMC article.
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis.
Honglin Wang, Thorsten Peters, +11 authors, Karin Scharffetter-Kochanek.
J Clin Invest, 2008 Jun 04; 118(7). PMID: 18521187    Free PMC article.
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.
Brian Kavanagh, Shaun O'Brien, +6 authors, Lawrence Fong.
Blood, 2008 Jun 05; 112(4). PMID: 18523152    Free PMC article.
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
Wendy W C van Maren, Joannes F M Jacobs, +2 authors, Gosse J Adema.
Immunology, 2008 Jun 11; 124(4). PMID: 18540962    Free PMC article.
Review.
Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.
William Stohl, Noam Jacob, +6 authors, Michael N Koss.
J Immunol, 2008 Jun 21; 181(1). PMID: 18566449    Free PMC article.
How regulatory T cells work.
Dario A A Vignali, Lauren W Collison, Creg J Workman.
Nat Rev Immunol, 2008 Jun 21; 8(7). PMID: 18566595    Free PMC article.
Highly Cited. Review.
Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation.
Amanda J Chase, Hung-Chih Yang, +2 authors, Robert F Siliciano.
J Virol, 2008 Jun 27; 82(17). PMID: 18579608    Free PMC article.
Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells.
Wenwei Tu, Yu-Lung Lau, +6 authors, David B Lewis.
Blood, 2008 Jul 05; 112(6). PMID: 18599794    Free PMC article.
IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen.
Javier Ochoa-Repáraz, Agnieszka Rynda, +6 authors, David W Pascual.
J Immunol, 2008 Jul 09; 181(2). PMID: 18606647    Free PMC article.
Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents.
Takayoshi Yamaza, Yasuo Miura, +11 authors, Songtao Shi.
PLoS One, 2008 Jul 10; 3(7). PMID: 18612428    Free PMC article.
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.
Yasushi Onishi, Zoltan Fehervari, Tomoyuki Yamaguchi, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2008 Jul 19; 105(29). PMID: 18635688    Free PMC article.
Highly Cited.
Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
Yong Zheng, Claire N Manzotti, +4 authors, David M Sansom.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641304    Free PMC article.
CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.
Anita L Tang, John R Teijaro, +5 authors, Donna L Farber.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641318    Free PMC article.
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Celine S Lages, Isabelle Suffia, +5 authors, Claire Chougnet.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641321    Free PMC article.
Highly Cited.
Gammadelta T lymphocytes: a new type of regulatory T cells suppressing murine 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis.
Jörg C Hoffmann, Nina N Pawlowski, +3 authors, Anja A Kühl.
Int J Colorectal Dis, 2008 Jul 24; 23(10). PMID: 18649083
The IL-10 and IFN-gamma pathways are essential to the potent immunosuppressive activity of cultured CD8+ NKT-like cells.
Li Zhou, Hongjie Wang, +7 authors, Jin-Xiong She.
Genome Biol, 2008 Jul 31; 9(7). PMID: 18664279    Free PMC article.
The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.
Jakob Michaëlsson, Hugo Marcelo R Barbosa, +9 authors, Esper G Kallas.
BMC Immunol, 2008 Jul 31; 9. PMID: 18664281    Free PMC article.
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Renata Mazzucchelli, Julie A Hixon, +7 authors, Scott K Durum.
Blood, 2008 Jul 31; 112(8). PMID: 18664628    Free PMC article.
Multiple sclerosis and regulatory T cells.
Cristina Maria Costantino, Clare Baecher-Allan, David A Hafler.
J Clin Immunol, 2008 Sep 03; 28(6). PMID: 18763026    Free PMC article.
Review.
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.
Amanda Huber, Francesca Menconi, +2 authors, Yaron Tomer.
Endocr Rev, 2008 Sep 09; 29(6). PMID: 18776148    Free PMC article.
Review.
Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells.
David C Gondek, Victor Devries, +4 authors, Randolph J Noelle.
J Immunol, 2008 Sep 20; 181(7). PMID: 18802078    Free PMC article.
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood.
Wakae Fujimaki, Nozomu Takahashi, +6 authors, Chikao Morimoto.
Clin Dev Immunol, 2008 Sep 26; 2008. PMID: 18815628    Free PMC article.
Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.
Koichiro Watanabe, Varada P Rao, +9 authors, James G Fox.
Infect Immun, 2008 Oct 01; 76(12). PMID: 18824539    Free PMC article.
Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.
Gisen Kim, Olga Turovskaya, +4 authors, Mitchell Kronenberg.
J Immunol, 2008 Oct 04; 181(8). PMID: 18832683    Free PMC article.
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.
Julia Yuen-Shan Tsang, Yakup Tanriver, +7 authors, Robert Lechler.
J Clin Invest, 2008 Oct 11; 118(11). PMID: 18846251    Free PMC article.
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
Valérie Dardalhon, Amit Awasthi, +10 authors, Vijay K Kuchroo.
Nat Immunol, 2008 Nov 11; 9(12). PMID: 18997793    Free PMC article.
Highly Cited.
Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells.
Kristian G Andersen, Tracey Butcher, Alexander G Betz.
PLoS Biol, 2008 Nov 13; 6(11). PMID: 18998771    Free PMC article.
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure.
Flurina Meiler, Judith Zumkehr, +3 authors, Mübeccel Akdis.
J Exp Med, 2008 Nov 13; 205(12). PMID: 19001136    Free PMC article.
Highly Cited.
Involvement of IL-10 in the suppression of antibody production by in vitro immunized peripheral blood mononuclear cells.
Makiko Yamashita, Yoshinori Katakura, +5 authors, Sanetaka Shirahata.
Cytotechnology, 2008 Nov 13; 55(2-3). PMID: 19002996    Free PMC article.
CD25+ T cells induce Helicobacter pylori-specific CD25- T-cell anergy but are not required to maintain persistent hyporesponsiveness.
Kathleen A Stuller, Hua Ding, +2 authors, Thomas G Blanchard.
Eur J Immunol, 2008 Nov 13; 38(12). PMID: 19003932    Free PMC article.
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Xin Yu, Kristin Harden, +9 authors, Jane L Grogan.
Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627
Highly Cited.
Induction of T regulatory cells attenuates idiopathic nephrotic syndrome.
Ludmilla Le Berre, Sarah Bruneau, +7 authors, Jacques Dantal.
J Am Soc Nephrol, 2008 Nov 21; 20(1). PMID: 19020006    Free PMC article.
APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes.
Yulan Jin, Xueqin Chen, +4 authors, Jin-Xiong She.
Clin Immunol, 2008 Nov 28; 130(3). PMID: 19036642    Free PMC article.
May genetic factors in fibromyalgia help to identify patients with differentially altered frequencies of immune cells?
L S C Carvalho, H Correa, +5 authors, D d'Avila Reis.
Clin Exp Immunol, 2008 Nov 29; 154(3). PMID: 19037919    Free PMC article.
Neonatal bacillus Calmette-Guérin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells.
Qian Li, Hua-hao Shen.
Acta Pharmacol Sin, 2008 Dec 09; 30(1). PMID: 19060917    Free PMC article.
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.
Jianda Yuan, Sacha Gnjatic, +17 authors, Jedd D Wolchok.
Proc Natl Acad Sci U S A, 2008 Dec 17; 105(51). PMID: 19074257    Free PMC article.
Highly Cited.
Immunoregulatory pathways controlling progression of autoimmunity in NOD mice.
Sylvaine You, Marie-Alexandra Alyanakian, +4 authors, Lucienne Chatenoud.
Ann N Y Acad Sci, 2009 Jan 06; 1150. PMID: 19120317    Free PMC article.
Review.
Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis.
E Bourreau, C Ronet, +6 authors, P Launois.
Infect Immun, 2009 Jan 27; 77(4). PMID: 19168733    Free PMC article.
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants.
Marta Barreto, Ricardo C Ferreira, +12 authors, Astrid M Vicente.
BMC Immunol, 2009 Jan 29; 10. PMID: 19173720    Free PMC article.
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Randall H Friedline, David S Brown, +7 authors, Cynthia A Chambers.
J Exp Med, 2009 Feb 04; 206(2). PMID: 19188497    Free PMC article.
Highly Cited.
Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge.
Jared H Rowe, Tanner M Johanns, +2 authors, Sing Sing Way.
Immunology, 2009 Feb 05; 128(1 Suppl). PMID: 19191906    Free PMC article.
Treatment of Crohn's disease with colony-stimulating factors: An overview.
Luisa Guidi, Giammarco Mocci, Manuela Marzo, Sergio Rutella.
Ther Clin Risk Manag, 2009 Feb 12; 4(5). PMID: 19209275    Free PMC article.
Reduced circulating CD4+CD25+ cell populations in haemorrhagic fever with renal syndrome.
L Y Zhu, L J Chi, X Wang, H Zhou.
Clin Exp Immunol, 2009 Feb 13; 156(1). PMID: 19210520    Free PMC article.
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.
Johan Verhagen, Leona Gabrysová, +4 authors, David C Wraith.
Proc Natl Acad Sci U S A, 2009 Feb 17; 106(9). PMID: 19218450    Free PMC article.
Effects of oral commensal and pathogenic bacteria on human dendritic cells.
T Chino, D M Santer, +5 authors, E A Clark.
Oral Microbiol Immunol, 2009 Feb 26; 24(2). PMID: 19239635    Free PMC article.
Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets.
Maria Nikolova, Jean-Daniel Lelievre, +2 authors, Yves Lévy.
Blood, 2009 Feb 28; 113(19). PMID: 19246340    Free PMC article.
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade.
Nobuhiro Nakamoto, Hyosun Cho, +8 authors, Kyong-Mi Chang.
PLoS Pathog, 2009 Feb 28; 5(2). PMID: 19247441    Free PMC article.
Highly Cited.
Regulatory T cells overturned: the effectors fight back.
Lucy S K Walker.
Immunology, 2009 Mar 13; 126(4). PMID: 19278420    Free PMC article.
Review.
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels.
Ulrike Lorenz.
Immunol Rev, 2009 Mar 18; 228(1). PMID: 19290938    Free PMC article.
Highly Cited. Review.
Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress.
Andrea L Szymczak-Workman, Creg J Workman, Dario A A Vignali.
J Immunol, 2009 Apr 22; 182(9). PMID: 19380762    Free PMC article.
CD4+ lymphocytes modulate prostate cancer progression in mice.
Theofilos Poutahidis, Varada P Rao, +7 authors, Susan E Erdman.
Int J Cancer, 2009 May 02; 125(4). PMID: 19408303    Free PMC article.
Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner.
Lauren W Collison, Meenu R Pillai, Vandana Chaturvedi, Dario A A Vignali.
J Immunol, 2009 May 06; 182(10). PMID: 19414764    Free PMC article.
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.
Hélène Bour-Jordan, Jeffrey A Bluestone.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426214    Free PMC article.
Review.
CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation.
Dorothy K Sojka, Angela Hughson, Deborah J Fowell.
Eur J Immunol, 2009 May 23; 39(6). PMID: 19462377    Free PMC article.
Molecular orchestration of differentiation and function of regulatory T cells.
Li-Fan Lu, Alexander Rudensky.
Genes Dev, 2009 Jun 03; 23(11). PMID: 19487568    Free PMC article.
Colitis-associated cancer: the role of T cells in tumor development.
Maximilian J Waldner, Markus F Neurath.
Semin Immunopathol, 2009 Jun 06; 31(2). PMID: 19495757
Review.
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.
C Coquerelle, G Oldenhove, +6 authors, M Moser.
Gut, 2009 Jun 10; 58(10). PMID: 19505881    Free PMC article.
Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells.
James D Lord, Robert C Hackman, +5 authors, George B McDonald.
Dig Dis Sci, 2009 Jun 10; 55(5). PMID: 19507029    Free PMC article.
Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population.
Belén Blanco, José A Pérez-Simón, +10 authors, Jesús F San Miguel.
Haematologica, 2009 Jun 11; 94(7). PMID: 19508976    Free PMC article.
Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.
Caroline E von Allmen, Nicole Schmitz, +8 authors, Martin F Bachmann.
Proc Natl Acad Sci U S A, 2009 Jul 01; 106(28). PMID: 19564598    Free PMC article.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Karl S Peggs, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407    Free PMC article.
Highly Cited.
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
Carol H Miao, Benjamin R Harmeling, +8 authors, David J Rawlings.
Blood, 2009 Aug 29; 114(19). PMID: 19713458    Free PMC article.
How do regulatory T cells work?
A Corthay.
Scand J Immunol, 2009 Sep 16; 70(4). PMID: 19751267    Free PMC article.
Highly Cited. Review.
Regulatory T cells and immune tolerance to tumors.
Xuefang Cao.
Immunol Res, 2009 Sep 19; 46(1-3). PMID: 19763889
Review.
Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.
Mei-Ling Chen, Bo-Shiun Yan, Deneen Kozoriz, Howard L Weiner.
Eur J Immunol, 2009 Sep 22; 39(12). PMID: 19768696    Free PMC article.
The role of costimulatory molecules in allergic disease and asthma.
Vincent Lombardi, Abinav K Singh, Omid Akbari.
Int Arch Allergy Immunol, 2009 Sep 30; 151(3). PMID: 19786798    Free PMC article.
Review.
Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation.
R A O'Connor, L S Taams, S M Anderton.
Clin Exp Immunol, 2009 Nov 17; 159(2). PMID: 19912249    Free PMC article.
Review.
Immune tolerance induction by integrating innate and adaptive immune regulators.
Jun Suzuki, Camillo Ricordi, Zhibin Chen.
Cell Transplant, 2009 Nov 19; 19(3). PMID: 19919733    Free PMC article.
Review.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
William Humphries, Jun Wei, John H Sampson, Amy B Heimberger.
Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972    Free PMC article.
Review.
CD4(+)CD25(+) regulatory T cells resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis.
Nagendra Singh, Mutsumi Yamamoto, +4 authors, Makio Iwashima.
J Immunol, 2009 Dec 02; 184(1). PMID: 19949106    Free PMC article.
TLR2-independent induction and regulation of chronic intestinal inflammation.
Olivier Boulard, Mark J Asquith, Fiona Powrie, Kevin J Maloy.
Eur J Immunol, 2009 Dec 02; 40(2). PMID: 19950179    Free PMC article.
Regulatory T cells exert checks and balances on self tolerance and autoimmunity.
Kajsa Wing, Shimon Sakaguchi.
Nat Immunol, 2009 Dec 18; 11(1). PMID: 20016504
Highly Cited. Review.
Gatekeepers of intestinal inflammation.
Heather A Arnett, Joanne L Viney.
Inflamm Res, 2010 Jan 13; 59(1). PMID: 20066780
Review.
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.
Nitya Jain, Hai Nguyen, Cynthia Chambers, Joonsoo Kang.
Proc Natl Acad Sci U S A, 2010 Jan 19; 107(4). PMID: 20080649    Free PMC article.
Fiona Powrie: Gut diplomacy. Interview by Amy Maxmen.
Fiona Powrie.
J Exp Med, 2010 Jan 20; 207(1). PMID: 20083579    Free PMC article.
Short-term administrations of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induce tolerance to neonatal porcine islet xenografts in mice.
Hossein Arefanian, Eric B Tredget, +3 authors, Gina R Rayat.
Diabetes, 2010 Jan 21; 59(4). PMID: 20086231    Free PMC article.
Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells.
Shuzi Zhang, Hehua Dai, +2 authors, Zhenhua Dai.
PLoS One, 2010 Jan 22; 5(1). PMID: 20090908    Free PMC article.
Association of two clones allows for optimal detection of human FOXP3.
Pietro Presicce, Maria E Moreno-Fernandez, +2 authors, Claire A Chougnet.
Cytometry A, 2010 Feb 18; 77(6). PMID: 20162533    Free PMC article.
Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases.
Franco Pandolfi, Rossella Cianci, +2 authors, Giovanni Cammarota.
Mediators Inflamm, 2010 Feb 20; 2009. PMID: 20169125    Free PMC article.
Review.
Regulatory T cells: roles of T cell receptor for their development and function.
Naganari Ohkura, Shimon Sakaguchi.
Semin Immunopathol, 2010 Feb 25; 32(2). PMID: 20179931
Review.
Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models.
Aya M Westbrook, Akos Szakmary, Robert H Schiestl.
Mutat Res, 2010 Mar 20; 705(1). PMID: 20298806    Free PMC article.
Review.
A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma.
Marie-Denise Poirier, Houda Haban, Abdeljabar El Andaloussi.
J Oncol, 2009 Jan 01; 2009. PMID: 20339520    Free PMC article.
Proliferation of CD4CD25Foxp3 regulatory T lymphocytes in ex vivo expanded ascitic fluid from primary and recurrent ovarian carcinoma.
Shin Wha Lee, Yong-Man Kim, +4 authors, Young-Tak Kim.
J Gynecol Oncol, 2010 Apr 10; 21(1). PMID: 20379446    Free PMC article.
CD8alpha+ dendritic cells prime TCR-peptide-reactive regulatory CD4+FOXP3- T cells.
Trevor R F Smith, Igor Maricic, +2 authors, Vipin Kumar.
Eur J Immunol, 2010 Apr 16; 40(7). PMID: 20394075    Free PMC article.
E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.
Karima R R Siddiqui, Sophie Laffont, Fiona Powrie.
Immunity, 2010 Apr 20; 32(4). PMID: 20399121    Free PMC article.
Highly Cited.
CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population.
Farha Deeba, Rabbani Syed, +3 authors, Hanmanth Rao.
Indian J Dermatol, 2010 Apr 27; 55(1). PMID: 20418973    Free PMC article.
Is aspirin treatment an appropriate intervention to osteoporosis?
Songtao Shi, Takayoshi Yamaza, Kentaro Akiyama.
Fut Rheumatol, 2008 Dec 01; 3(6). PMID: 20428329    Free PMC article.
The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells.
Pu Feng, Hong Wang, +2 authors, Paul A S Breslin.
Chem Senses, 2010 May 12; 35(6). PMID: 20457570    Free PMC article.
In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus.
S Rochelle Mikkelsen, Stacie K Reckling, Erin A Egan, Gregg A Dean.
Virology, 2010 May 18; 403(2). PMID: 20471053    Free PMC article.
CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model.
Haruei Ogino, Kazuhiko Nakamura, +2 authors, Ryoichi Takayanagi.
Dig Dis Sci, 2010 Jun 04; 56(2). PMID: 20521112
The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease.
Ondrej Hradsky, Petra Dusatkova, +6 authors, Ondrej Cinek.
BMC Med Genet, 2010 Jun 12; 11. PMID: 20537165    Free PMC article.
Modulation of CTLA-4 and GITR for cancer immunotherapy.
Francesca Avogadri, Jianda Yuan, +2 authors, Jedd D Wolchok.
Curr Top Microbiol Immunol, 2010 Jun 22; 344. PMID: 20563707    Free PMC article.
Review.
The PD-1 pathway in tolerance and autoimmunity.
Loise M Francisco, Peter T Sage, Arlene H Sharpe.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636820    Free PMC article.
Highly Cited. Review.
Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection.
Ross B Fulton, David K Meyerholz, Steven M Varga.
J Immunol, 2010 Jul 20; 185(4). PMID: 20639494    Free PMC article.
Highly Cited.
Therapeutic potential of TGF-β-induced CD4(+) Foxp3(+) regulatory T cells in autoimmune diseases.
Xiaohui Zhou, Ning Kong, +4 authors, Song Guo Zheng.
Autoimmunity, 2010 Jul 31; 44(1). PMID: 20670119    Free PMC article.
Review.
Gene expression profiling of the local cecal response of genetic chicken lines that differ in their susceptibility to Campylobacter jejuni colonization.
Xianyao Li, Christina L Swaggerty, +5 authors, Huaijun Zhou.
PLoS One, 2010 Aug 03; 5(7). PMID: 20676366    Free PMC article.
Checks and balances: IL-23 in the intestine.
Samuel Huber, Richard A Flavell.
Immunity, 2010 Aug 25; 33(2). PMID: 20732638    Free PMC article.
Interleukin-23 drives intestinal inflammation through direct activity on T cells.
Philip P Ahern, Chris Schiering, +4 authors, Fiona Powrie.
Immunity, 2010 Aug 25; 33(2). PMID: 20732640    Free PMC article.
Highly Cited.
IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions.
Cécile Le Saout, Marine Villard, +3 authors, Javier Hernandez.
PLoS One, 2010 Sep 22; 5(9). PMID: 20856822    Free PMC article.
Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells.
Carol H Miao.
Expert Rev Hematol, 2010 Oct 27; 3(4). PMID: 20976115    Free PMC article.
Review.
Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination.
Matteo Vergati, Vittore Cereda, +7 authors, Kwong Y Tsang.
Cancer Immunol Immunother, 2010 Oct 27; 60(2). PMID: 20976449    Free PMC article.
Evaluation of the immunoregulatory activity of intraepithelial lymphocytes in a mouse model of chronic intestinal inflammation.
D V Ostanin, C M Brown, +2 authors, M B Grisham.
Int Immunol, 2010 Nov 13; 22(12). PMID: 21071622    Free PMC article.
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.
Margaret K Callahan, Jedd D Wolchok, James P Allison.
Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074063    Free PMC article.
Review.
T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD.
Amir J Guri, Nicholas P Evans, Raquel Hontecillas, Josep Bassaganya-Riera.
J Nutr Biochem, 2010 Nov 27; 22(9). PMID: 21109419    Free PMC article.
IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression.
Kathrin Eller, Dominik Wolf, +6 authors, Anna M Wolf.
J Immunol, 2010 Dec 01; 186(1). PMID: 21115728    Free PMC article.
The role of natural regulatory T cells in infection.
Ana M Sanchez, Yiping Yang.
Immunol Res, 2010 Dec 01; 49(1-3). PMID: 21116872    Free PMC article.
Review.
Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu.
Anagha A Divekar, Shweta Dubey, Pallavi R Gangalum, Ram Raj Singh.
J Immunol, 2010 Dec 15; 186(2). PMID: 21149603    Free PMC article.
The type of responder T-cell has a significant impact in a human in vitro suppression assay.
Srikanta Jana, Hope Campbell, +5 authors, Sanja Glisic.
PLoS One, 2010 Dec 15; 5(12). PMID: 21151941    Free PMC article.
Role of CD4CD25FOXP3 Regulatory T Cells in Psoriasis.
Woo-Jin Yun, Deok-Woo Lee, +8 authors, Jee-Ho Choi.
Ann Dermatol, 2010 Dec 18; 22(4). PMID: 21165208    Free PMC article.
Releasing the brake on the immune system: ipilimumab in melanoma and other tumors.
Ahmad Tarhini, Ernest Lo, David R Minor.
Cancer Biother Radiopharm, 2011 Jan 06; 25(6). PMID: 21204754    Free PMC article.
Review.
Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells.
R C Dutra, M Cola, +5 authors, J B Calixto.
Br J Pharmacol, 2011 Jan 20; 163(2). PMID: 21244371    Free PMC article.
T-cell subset regulation in atopy.
Marek Jutel, Cezmi A Akdis.
Curr Allergy Asthma Rep, 2011 Jan 29; 11(2). PMID: 21271314    Free PMC article.
Review.
In vitro Treg suppression assays.
Lauren W Collison, Dario A A Vignali.
Methods Mol Biol, 2011 Feb 03; 707. PMID: 21287326    Free PMC article.
Genetic susceptibility to autoimmune liver disease.
Jochen Mattner.
World J Hepatol, 2011 Feb 11; 3(1). PMID: 21307981    Free PMC article.
Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: tools for allogeneic transplantation.
Scott S Graves, Diane M Stone, +6 authors, Rainer Storb.
Transplantation, 2011 Feb 24; 91(8). PMID: 21343872    Free PMC article.
Allogeneic apoptotic thymocyte-stimulated dendritic cells expand functional regulatory T cells.
Thaís Boccia da Costa, Luiz R Sardinha, +2 authors, Luiz V Rizzo.
Immunology, 2011 Mar 02; 133(1). PMID: 21355864    Free PMC article.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom.
Science, 2011 Apr 09; 332(6029). PMID: 21474713    Free PMC article.
Highly Cited.
Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations.
Jochen Maul, Martin Zeitz.
Langenbecks Arch Surg, 2011 Apr 12; 397(1). PMID: 21479621
Review.
In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy.
James C Lee, Erik Hayman, +4 authors, Renier Brentjens.
Cancer Res, 2011 Apr 14; 71(8). PMID: 21487038    Free PMC article.
Treatment with IP-10 induces host-protective immune response by regulating the T regulatory cell functioning in Leishmania donovani-infected mice.
Gaurav Gupta, Saikat Majumdar, +4 authors, Subrata Majumdar.
Med Microbiol Immunol, 2011 May 03; 200(4). PMID: 21533785
Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3.
André Hoerning, Kerith Koss, +9 authors, David M Briscoe.
Eur J Immunol, 2011 May 04; 41(8). PMID: 21538345    Free PMC article.
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
Todd V Brennan, Qizhi Tang, +4 authors, Sang-Mo Kang.
J Surg Res, 2011 May 17; 169(1). PMID: 21571317    Free PMC article.
Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity.
Masako Nakanishi, Antoine Menoret, +4 authors, Daniel W Rosenberg.
Cancer Prev Res (Phila), 2011 May 18; 4(8). PMID: 21576350    Free PMC article.
The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function.
Kay D Gerold, Peilin Zheng, +3 authors, Stephan Kissler.
Diabetes, 2011 May 24; 60(7). PMID: 21602513    Free PMC article.
The variation of CD4+CD25+ regulatory T cells in the periphery blood and tumor microenvironment of non-small cell lung cancer patients and the downregulation effects induced by CpG ODN.
Yan-Ying Wang, Xiao-Ye He, +2 authors, Shao-Hua Lu.
Target Oncol, 2011 May 26; 6(3). PMID: 21611754
Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice.
Eva Gückel, Silke Frey, +3 authors, Reinhard E Voll.
PLoS One, 2011 Jun 01; 6(5). PMID: 21625598    Free PMC article.
Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.
Xin Chen, Joost J Oppenheim.
Int Immunopharmacol, 2011 Jun 04; 11(10). PMID: 21635972    Free PMC article.
Review.
Regulatory T cells phenotype in different clinical forms of Chagas' disease.
Fernanda Fortes de Araújo, Danielle Marquete Vitelli-Avelar, +8 authors, Olindo Assis Martins-Filho.
PLoS Negl Trop Dis, 2011 Jun 10; 5(5). PMID: 21655351    Free PMC article.
Review.
Transplantation tolerance: Clinical potential of regulatory T cells.
Yannick D Muller, Jörg D Seebach, +2 authors, Dela Golshayan.
Self Nonself, 2011 Jul 22; 2(1). PMID: 21776332    Free PMC article.
Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling.
Felipe Saldanha-Araujo, Rodrigo Haddad, +8 authors, Rodrigo A Panepucci.
J Cell Mol Med, 2011 Jul 23; 16(6). PMID: 21777379    Free PMC article.
Characterization of antigenic variants of hepatitis C virus in immune evasion.
Jane H Wang, Matthew J Pianko, +6 authors, Lijun Rong.
Virol J, 2011 Aug 02; 8. PMID: 21801418    Free PMC article.
Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis.
Narendra P Singh, Udai P Singh, +3 authors, Prakash S Nagarkatti.
PLoS One, 2011 Aug 23; 6(8). PMID: 21858153    Free PMC article.
Highly Cited.
Intravenous injection of endogenous microbial components abrogates DSS-induced colitis.
Beate C Sydora, Eric J Albert, +3 authors, Richard N Fedorak.
Dig Dis Sci, 2011 Sep 02; 57(2). PMID: 21881971
Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Henry K Wong, Anjali Mishra, Timothy Hake, Pierluigi Porcu.
Br J Haematol, 2011 Sep 03; 155(2). PMID: 21883142    Free PMC article.
Review.
Regulatory T cell: a protection for tumour cells.
Yi Wang, Yushui Ma, +4 authors, Xizhong Shen.
J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966    Free PMC article.
Review.
Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors.
Derek A Wainwright, Sadhak Sengupta, Yu Han, Maciej S Lesniak.
Neuro Oncol, 2011 Sep 13; 13(12). PMID: 21908444    Free PMC article.
Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy.
Kathrin Eller, Alexander Kirsch, +7 authors, Philipp Eller.
Diabetes, 2011 Sep 14; 60(11). PMID: 21911743    Free PMC article.
Highly Cited.
Influence of short-term glucocorticoid therapy on regulatory T cells in vivo.
Silviu Sbiera, Thomas Dexneit, +10 authors, Martin Fassnacht.
PLoS One, 2011 Sep 14; 6(9). PMID: 21912688    Free PMC article.
GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.
Elizabeth A Wohlfert, John R Grainger, +14 authors, Yasmine Belkaid.
J Clin Invest, 2011 Oct 04; 121(11). PMID: 21965331    Free PMC article.
Highly Cited.
Inflammatory bowel disease: is it a primary immunodeficiency?
Erik Glocker, Bodo Grimbacher.
Cell Mol Life Sci, 2011 Oct 15; 69(1). PMID: 21997382
Review.
Induction of contact-dependent CD8(+) regulatory T cells through stimulation with staphylococcal and streptococcal superantigens.
Amanda L Taylor, Elizabeth L A Cross, Martin J Llewelyn.
Immunology, 2011 Nov 03; 135(2). PMID: 22043981    Free PMC article.
Identification of a unique double-negative regulatory T-cell population.
Byung O Lee, Joyce E Jones, +5 authors, David R Milich.
Immunology, 2011 Nov 03; 134(4). PMID: 22044159    Free PMC article.
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524    Free PMC article.
Review.
T regulatory cells in B-cell malignancy - tumour support or kiss of death?
Camilla A Lindqvist, Angelica S I Loskog.
Immunology, 2011 Nov 25; 135(4). PMID: 22112044    Free PMC article.
Review.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Lucy S K Walker, David M Sansom.
Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087
Highly Cited.
Lung function early after lung transplantation is correlated with the frequency of regulatory T cells.
Tomoyuki Nakagiri, Gregor Warnecke, +12 authors, Martin Strüber.
Surg Today, 2011 Dec 17; 42(3). PMID: 22173646
Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury.
Li-Wen Lai, Kim-Chong Yong, Yeong-Hau H Lien.
Kidney Int, 2011 Dec 23; 81(10). PMID: 22189844    Free PMC article.
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment.
Christopher Jackson, Jacob Ruzevick, +2 authors, Michael Lim.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190972    Free PMC article.
Review.
Regulatory T cells: mechanisms of differentiation and function.
Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781    Free PMC article.
Highly Cited. Review.
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.
Aymeric Rivollier, Jianping He, +2 authors, Brian L Kelsall.
J Exp Med, 2012 Jan 11; 209(1). PMID: 22231304    Free PMC article.
Highly Cited.
Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
Yong Chen, Shudan Shen, +2 authors, Xiao-Ping Zhong.
J Immunol, 2012 Jan 11; 188(4). PMID: 22231701    Free PMC article.
Targeting regulatory T cells.
Christine Ménétrier-Caux, Tyler Curiel, +3 authors, Weiping Zou.
Target Oncol, 2012 Feb 14; 7(1). PMID: 22327882
Review.
Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis.
Saleh A Naser, Melissa Arce, +4 authors, Saisathya Thanigachalam.
World J Gastroenterol, 2012 Feb 22; 18(5). PMID: 22346247    Free PMC article.
Review.
Correlation between the cord vitamin D levels and regulatory T cells in newborn infants.
Ayşegül Güven, Ayşe Ecevit, +3 authors, Namık Ozbek.
Eur J Pediatr, 2012 Mar 03; 171(8). PMID: 22383070
Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice.
Shounan Yi, Ming Ji, +4 authors, Philip J O'Connell.
Diabetes, 2012 Mar 10; 61(5). PMID: 22403295    Free PMC article.
Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid.
Mojgan Zadeh, Mohammad W Khan, +4 authors, Mansour Mohamadzadeh.
J Inflamm (Lond), 2012 Mar 20; 9. PMID: 22423982    Free PMC article.
Regulation generation: the suppressive functions of human regulatory T cells.
Wendy A Goodman, Kevin D Cooper, Thomas S McCormick.
Crit Rev Immunol, 2012 Mar 21; 32(1). PMID: 22428855    Free PMC article.
Review.
Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism.
Guilin Qiao, Lifen Yang, +4 authors, Jian Zhang.
Clin Immunol, 2012 Mar 31; 143(2). PMID: 22459706    Free PMC article.
Regulatory T cells in human ovarian cancer.
Dong-Jun Peng, Rebecca Liu, Weiping Zou.
J Oncol, 2012 Apr 07; 2012. PMID: 22481922    Free PMC article.
Immunoregulation by the gut microbiota.
Junko Nishio, Kenya Honda.
Cell Mol Life Sci, 2012 Apr 25; 69(21). PMID: 22527722
Review.
Requirements for growth and IL-10 expression of highly purified human T regulatory cells.
Benedetta Bonacci, Brandon Edwards, +4 authors, James W Verbsky.
J Clin Immunol, 2012 May 09; 32(5). PMID: 22562448    Free PMC article.
Molecular mechanisms of treg-mediated T cell suppression.
Angelika Schmidt, Nina Oberle, Peter H Krammer.
Front Immunol, 2012 May 09; 3. PMID: 22566933    Free PMC article.
Highly Cited.
On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation.
Anja U Engela, Carla C Baan, +2 authors, Martin J Hoogduijn.
Front Immunol, 2012 May 26; 3. PMID: 22629256    Free PMC article.
Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation?
Francisco Salcido-Ochoa, Nurhashikin Yusof, +3 authors, Olaf Rotzschke.
J Transplant, 2012 Jun 13; 2012. PMID: 22690325    Free PMC article.
Boosting regulatory T cell function by CD4 stimulation enters the clinic.
Christian Becker, Tobias Bopp, Helmut Jonuleit.
Front Immunol, 2012 Jun 22; 3. PMID: 22719741    Free PMC article.
Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance.
Mara Kornete, Ciriaco A Piccirillo.
Front Immunol, 2012 Jun 28; 3. PMID: 22737152    Free PMC article.
Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
Chun Jing Wang, Rupert Kenefeck, +6 authors, Lucy S K Walker.
J Immunol, 2012 Jul 04; 189(3). PMID: 22753931    Free PMC article.
Homeostasis and function of regulatory T cells in HIV/SIV infection.
Maria E Moreno-Fernandez, Pietro Presicce, Claire A Chougnet.
J Virol, 2012 Jul 20; 86(19). PMID: 22811537    Free PMC article.
Review.
Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms.
Weihua Zhao, David R Beers, +2 authors, Stanley H Appel.
Neurobiol Dis, 2012 Jul 24; 48(3). PMID: 22820142    Free PMC article.
Autologous regulatory T cells for the treatment of type 1 diabetes.
James A Thompson, Daniel Perry, Todd M Brusko.
Curr Diab Rep, 2012 Jul 31; 12(5). PMID: 22843491
Review.
Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation.
Leela Rani Avula, Dries Knapen, +4 authors, Jean-Pierre Timmermans.
BMC Genomics, 2012 Aug 08; 13. PMID: 22866923    Free PMC article.
CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
M J Barnes, T Griseri, +3 authors, A Izcue.
Mucosal Immunol, 2012 Aug 23; 6(2). PMID: 22910217    Free PMC article.
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Dalya R Soond, Elizabeth C M Slack, +2 authors, Klaus Okkenhaug.
Front Immunol, 2012 Aug 23; 3. PMID: 22912633    Free PMC article.
Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells.
Rafael M Rezende, Rafael P Oliveira, +10 authors, Ana M C Faria.
J Autoimmun, 2012 Sep 04; 40. PMID: 22939403    Free PMC article.
Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression.
Leticia Corrales, Daniel Ajona, +7 authors, Ruben Pio.
J Immunol, 2012 Oct 03; 189(9). PMID: 23028051    Free PMC article.
Highly Cited.
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.
Yuning Lu, Helga Schneider, Christopher E Rudd.
Blood, 2012 Oct 11; 120(23). PMID: 23047820    Free PMC article.
The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells.
Andrea Balogh, Eszter Persa, +4 authors, Katalin Lumniczky.
Inflamm Res, 2012 Oct 20; 62(2). PMID: 23080082
Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions.
Joshua F Heiber, Terrence L Geiger.
Cell Immunol, 2012 Oct 24; 279(1). PMID: 23089195    Free PMC article.
Review.
Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes.
Yoshiki Shigematsu, Takeshi Hanagiri, +8 authors, Fumihiro Tanaka.
Oncol Lett, 2012 Dec 04; 4(4). PMID: 23205074    Free PMC article.
The role of B7 family molecules in hematologic malignancy.
Paul Greaves, John G Gribben.
Blood, 2012 Dec 12; 121(5). PMID: 23223433    Free PMC article.
Review.
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?
V Kumar.
Purinergic Signal, 2012 Dec 29; 9(2). PMID: 23271562    Free PMC article.
Review.
A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes.
Gisen Kim, Ryo Shinnakasu, +2 authors, Mitchell Kronenberg.
J Immunol, 2013 Jan 22; 190(4). PMID: 23335749    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells.
Wing-hong Kwan, William van der Touw, +2 authors, Peter S Heeger.
J Exp Med, 2013 Feb 06; 210(2). PMID: 23382542    Free PMC article.
Highly Cited.
CD4(+) T-cell subsets in intestinal inflammation.
Matthew Shale, Chris Schiering, Fiona Powrie.
Immunol Rev, 2013 Feb 15; 252(1). PMID: 23405904    Free PMC article.
Review.
Functional complexity of the Leishmania granuloma and the potential of in silico modeling.
John W J Moore, Daniel Moyo, +3 authors, Paul M Kaye.
Front Immunol, 2013 Feb 21; 4. PMID: 23423646    Free PMC article.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Molecular signatures of T-cell inhibition in HIV-1 infection.
Marie Larsson, Esaki M Shankar, +5 authors, Adeeba Kamarulzaman.
Retrovirology, 2013 Mar 22; 10. PMID: 23514593    Free PMC article.
Review.
Nutritional protective mechanisms against gut inflammation.
Monica Viladomiu, Raquel Hontecillas, +2 authors, Josep Bassaganya-Riera.
J Nutr Biochem, 2013 Apr 02; 24(6). PMID: 23541470    Free PMC article.
Review.
Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes.
M Pihl, L Akerman, +5 authors, R Casas.
Clin Exp Immunol, 2013 Apr 23; 172(3). PMID: 23600827    Free PMC article.
Indoleamine 2,3 dioxygenase contributes to transferable tolerance in rat red blood cell inducible model of experimental autoimmune haemolytic anaemia.
L N Dahal, L S Hall, R N Barker, F J Ward.
Clin Exp Immunol, 2013 Apr 24; 173(1). PMID: 23607691    Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
Monitoring regulatory immune responses in tumor immunotherapy clinical trials.
Brian M Olson, Douglas G McNeel.
Front Oncol, 2013 May 09; 3. PMID: 23653893    Free PMC article.
Leptin antagonist ameliorates chronic colitis in IL-10⁻/⁻ mice.
Udai P Singh, Narendra P Singh, +7 authors, Prakash S Nagarkatti.
Immunobiology, 2013 Jun 04; 218(12). PMID: 23726523    Free PMC article.
Analysis of circulating regulatory T cells (CD4+CD25+CD127-) after cryosurgery in prostate cancer.
Tong-Guo Si, Jun-Ping Wang, Zhi Guo.
Asian J Androl, 2013 Jun 04; 15(4). PMID: 23728588    Free PMC article.
The role of the immune system in governing host-microbe interactions in the intestine.
Eric M Brown, Manish Sadarangani, B Brett Finlay.
Nat Immunol, 2013 Jun 20; 14(7). PMID: 23778793
Highly Cited. Review.
Treatment of graft-versus-host disease with naturally occurring T regulatory cells.
Piotr Trzonkowski, Anna Dukat-Mazurek, +6 authors, Andrzej Hellmann.
BioDrugs, 2013 Jul 03; 27(6). PMID: 23813436    Free PMC article.
Review.
The emerging role of leptin antagonist as potential therapeutic option for inflammatory bowel disease.
Udai P Singh, Narendra P Singh, +7 authors, Prakash S Nagarkatti.
Int Rev Immunol, 2013 Jul 12; 33(1). PMID: 23841494    Free PMC article.
Review.
Treg and CTLA-4: two intertwining pathways to immune tolerance.
Lucy S K Walker.
J Autoimmun, 2013 Jul 16; 45. PMID: 23849743    Free PMC article.
Highly Cited. Review.
Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells.
Cong Wu, Yi Zhang, +5 authors, Guoyou Chen.
Cell Mol Immunol, 2013 Jul 23; 10(5). PMID: 23872920    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
T cell Receptor Signal Transduction in T lymphocytes.
Balachandra K Gorentla, Xiao-Ping Zhong.
J Clin Cell Immunol, 2013 Aug 16; 2012(Suppl 12). PMID: 23946894    Free PMC article.
CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β.
Christine M Deppong, Traci L Bricker, +3 authors, Jonathan M Green.
J Immunol, 2013 Aug 21; 191(6). PMID: 23956428    Free PMC article.
ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection.
Qiang Wu, Gail J Gardiner, +11 authors, Rebecca A Shilling.
PLoS One, 2013 Aug 24; 8(8). PMID: 23967339    Free PMC article.
PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.
Pin Zhang, Takashi Maruyama, +4 authors, Wanjun Chen.
PLoS One, 2013 Aug 27; 8(8). PMID: 23977081    Free PMC article.
Regulatory T cells and Atherosclerosis.
Jahaira Lopez Pastrana, Xiaojin Sha, +5 authors, Xiao-Feng Yang.
J Clin Exp Cardiolog, 2013 Sep 03; 2012(Suppl 12). PMID: 23997979    Free PMC article.
FOXP3⁺ T regulatory cell modifications in inflammatory bowel disease patients treated with anti-TNFα agents.
Luisa Guidi, Carla Felice, +11 authors, Sergio Rutella.
Biomed Res Int, 2013 Sep 26; 2013. PMID: 24063002    Free PMC article.
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis.
Su-Jin Moon, Jin-Sil Park, +11 authors, Mi-La Cho.
Exp Mol Med, 2013 Oct 05; 45. PMID: 24091748    Free PMC article.
Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner.
Qiuming He, Y Maurice Morillon, +5 authors, Roland Tisch.
J Immunol, 2013 Nov 08; 191(12). PMID: 24198282    Free PMC article.
Regulatory T cells in colorectal cancer: from biology to prognostic relevance.
Dimitrios Mougiakakos.
Cancers (Basel), 2011 Jan 01; 3(2). PMID: 24212779    Free PMC article.
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.
James W Verbsky, Talal A Chatila.
Curr Opin Pediatr, 2013 Nov 19; 25(6). PMID: 24240290    Free PMC article.
Review.
Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.
Altin Gjymishka, Roxana M Coman, Todd M Brusko, Sarah C Glover.
Immunotherapy, 2013 Nov 29; 5(12). PMID: 24283846    Free PMC article.
Review.
ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner.
Jian Zheng, Ping-Lung Chan, +6 authors, Wenwei Tu.
PLoS One, 2013 Dec 07; 8(12). PMID: 24312642    Free PMC article.
Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.
V Dugas, A Liston, +6 authors, S Lesage.
Genes Immun, 2013 Dec 18; 15(2). PMID: 24335706
Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go.
Angela Vasaturo, Stefania Di Blasio, +4 authors, Stanleyson V Hato.
Front Immunol, 2013 Dec 19; 4. PMID: 24348481    Free PMC article.
Review.
Efficient expansion of cryopreserved CD4(+)CD25(+)CD127(lo/-) cells in Type 1 diabetes.
Anna Rydén, Maria Faresjö.
Results Immunol, 2011 Jan 01; 1(1). PMID: 24371551    Free PMC article.
Mechanisms of immune tolerance to allergens in children.
Umut C Kucuksezer, Cevdet Ozdemir, Mübeccel Akdis, Cezmi A Akdis.
Korean J Pediatr, 2014 Jan 15; 56(12). PMID: 24416044    Free PMC article.
Review.
CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells.
Cecilia Fernandez-Ponce, Margarita Dominguez-Villar, Enrique Aguado, Francisco Garcia-Cozar.
PLoS One, 2014 Jan 28; 9(1). PMID: 24465502    Free PMC article.
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.
Mathieu Angin, Paul L Klarenbeek, +10 authors, Marylyn M Addo.
PLoS One, 2014 Feb 06; 9(2). PMID: 24498287    Free PMC article.
Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance.
Jason Miska, Midhat H Abdulreda, +5 authors, Zhibin Chen.
J Exp Med, 2014 Feb 26; 211(3). PMID: 24567447    Free PMC article.
The gut microbiota in mouse models of inflammatory bowel disease.
Kalliopi K Gkouskou, Chrysoula Deligianni, Christos Tsatsanis, Aristides G Eliopoulos.
Front Cell Infect Microbiol, 2014 Mar 13; 4. PMID: 24616886    Free PMC article.
Review.
Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.
Linda C Sandin, Fredrik Eriksson, +3 authors, Sara M Mangsbo.
Oncoimmunology, 2014 Apr 05; 3(1). PMID: 24701377    Free PMC article.
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.
Kok-Fai Kong, Guo Fu, +10 authors, Amnon Altman.
Nat Immunol, 2014 Apr 08; 15(5). PMID: 24705298    Free PMC article.
Highly Cited.
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.
Kesley Attridge, Lucy S K Walker.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712457    Free PMC article.
Review.
CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints--analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood.
Babak Moradi, Philipp Schnatzer, +7 authors, Theresa Tretter.
Arthritis Res Ther, 2014 Apr 20; 16(2). PMID: 24742142    Free PMC article.
CD4⁺CD25⁻Foxp3⁺ T cells: a marker for lupus nephritis?
Michael Bonelli, Lisa Göschl, +5 authors, Clemens Scheinecker.
Arthritis Res Ther, 2014 Apr 30; 16(2). PMID: 24774748    Free PMC article.
Bifidobacterium breve attenuates murine dextran sodium sulfate-induced colitis and increases regulatory T cell responses.
Bin Zheng, Jeroen van Bergenhenegouwen, +6 authors, Aletta D Kraneveld.
PLoS One, 2014 May 03; 9(5). PMID: 24787575    Free PMC article.
Bacillus Calmette-Guérin Suppresses Asthmatic Responses via CD4(+)CD25(+) Regulatory T Cells and Dendritic Cells.
Young-Joon Kim, Ha-Jung Kim, +6 authors, Soo-Jong Hong.
Allergy Asthma Immunol Res, 2014 May 21; 6(3). PMID: 24843794    Free PMC article.
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients.
Edward Cha, Mark Klinger, +4 authors, Lawrence Fong.
Sci Transl Med, 2014 May 30; 6(238). PMID: 24871131    Free PMC article.
Highly Cited.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.
Yi-Chi M Kong, Jeffrey C Flynn.
Front Immunol, 2014 Jun 07; 5. PMID: 24904570    Free PMC article.
Review.
Animal models of inflammatory bowel disease: a review.
Nidhi Goyal, Ajay Rana, +2 authors, Puneet Kumar.
Inflammopharmacology, 2014 Jun 08; 22(4). PMID: 24906689
Review.
Helicobacter pylori infection and inflammatory bowel disease: is there a link?
Konstantinos Papamichael, Panagiotis Konstantopoulos, Gerassimos J Mantzaris.
World J Gastroenterol, 2014 Jun 11; 20(21). PMID: 24914359    Free PMC article.
Review.
Antigen-Pulsed CpG-ODN-Activated Dendritic Cells Induce Host-Protective Immune Response by Regulating the T Regulatory Cell Functioning in Leishmania donovani-Infected Mice: Critical Role of CXCL10.
Saikat Majumder, Amrita Bhattacharjee, +2 authors, Subrata Majumdar.
Front Immunol, 2014 Jun 14; 5. PMID: 24926293    Free PMC article.
Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.
Laura Esposito, Kara M D Hunter, +12 authors, Linda S Wicker.
J Immunol, 2014 Jun 15; 193(2). PMID: 24928993    Free PMC article.
The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts.
Peter Urbanellis, Wendy Shyu, +12 authors, Andrzej Chruscinski.
Immunology, 2014 Jul 06; 144(1). PMID: 24990517    Free PMC article.
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
Chris Schiering, Thomas Krausgruber, +13 authors, Fiona Powrie.
Nature, 2014 Jul 22; 513(7519). PMID: 25043027    Free PMC article.
Highly Cited.
Direct detection of FoxP3 expression in thymic double-negative CD4-CD8- cells by flow cytometry.
Gang Liu, Zongfang Li, +3 authors, Tie Liu.
Sci Rep, 2014 Jul 26; 4. PMID: 25060864    Free PMC article.
Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.
Daniel S Shin, Ayana Jordan, +5 authors, Fernando Macian.
EMBO Rep, 2014 Jul 31; 15(9). PMID: 25074018    Free PMC article.
T helper subsets in allergic eye disease.
Nancy J Reyes, Daniel R Saban.
Curr Opin Allergy Clin Immunol, 2014 Aug 12; 14(5). PMID: 25111509    Free PMC article.
Review.
Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8.
Justin P Edwards, Angela M Thornton, Ethan M Shevach.
J Immunol, 2014 Aug 17; 193(6). PMID: 25127859    Free PMC article.
CD4+CD25hiCD127low regulatory T cells are increased in oral squamous cell carcinoma patients.
Kue Peng Lim, Nicole Ai Leng Chun, +6 authors, Sok Ching Cheong.
PLoS One, 2014 Aug 26; 9(8). PMID: 25153698    Free PMC article.
TGFβ in T cell biology and tumor immunity: Angel or devil?
Eric Tu, Pei Zhi Cheryl Chia, Wanjun Chen.
Cytokine Growth Factor Rev, 2014 Aug 27; 25(4). PMID: 25156420    Free PMC article.
Review.
Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.
Sheetal Bodhankar, Yingxin Chen, +3 authors, Halina Offner.
Front Cell Neurosci, 2014 Aug 27; 8. PMID: 25157219    Free PMC article.
Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy.
Shirin Karimi, Subhasis Chattopadhyay, Nitya G Chakraborty.
Immunology, 2014 Sep 23; 144(2). PMID: 25243729    Free PMC article.
Review.
Tolerance in organ transplantation: from conventional immunosuppression to extracellular vesicles.
Marta Monguió-Tortajada, Ricardo Lauzurica-Valdemoros, Francesc E Borràs.
Front Immunol, 2014 Oct 04; 5. PMID: 25278936    Free PMC article.
Review.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Desirée Schubert, Claudia Bode, +37 authors, Bodo Grimbacher.
Nat Med, 2014 Oct 21; 20(12). PMID: 25329329    Free PMC article.
Highly Cited.
Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.
S M Krummey, M L Ford.
Am J Transplant, 2014 Nov 13; 14(12). PMID: 25387592    Free PMC article.
Review.
Anti-TNF-alpha loss of response is associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with Crohn's disease.
Oriol Juanola, Alba Moratalla, +8 authors, Rubén Francés.
J Gastroenterol, 2014 Dec 17; 50(7). PMID: 25500977
Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Linh T Nguyen, Pamela S Ohashi.
Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622
Highly Cited. Review.
Confusing signals: recent progress in CTLA-4 biology.
Lucy S K Walker, David M Sansom.
Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039    Free PMC article.
Highly Cited. Review.
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.
Dalil Hannani, Marie Vétizou, +30 authors, Laurence Zitvogel.
Cell Res, 2015 Jan 15; 25(2). PMID: 25582080    Free PMC article.
Highly Cited.
T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis.
Rhoanne C McPherson, Darryl G Turner, +2 authors, Stephen M Anderton.
Front Immunol, 2015 Mar 06; 6. PMID: 25741342    Free PMC article.
N-3-(oxododecanoyl)-L-homoserine lactone promotes the induction of regulatory T-cells by preventing human dendritic cell maturation.
Youqiang Li, Huayou Zhou, +7 authors, Jianping Liu.
Exp Biol Med (Maywood), 2015 Mar 10; 240(7). PMID: 25749498    Free PMC article.
Harnessing regulatory T cells for the treatment of inflammatory bowel disease.
Duke Geem, Akihito Harusato, Kyle Flannigan, Timothy L Denning.
Inflamm Bowel Dis, 2015 Mar 21; 21(6). PMID: 25793328    Free PMC article.
Review.
Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults.
Steven A Yukl, Amandeep K Shergill, +10 authors, Joseph K Wong.
PLoS One, 2015 Mar 27; 10(3). PMID: 25811360    Free PMC article.
Korean Red Ginseng and Ginsenoside-Rb1/-Rg1 Alleviate Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells and Upregulating Regulatory T Cells.
Min Jung Lee, Minhee Jang, +9 authors, Ik-Hyun Cho.
Mol Neurobiol, 2015 Apr 08; 53(3). PMID: 25846819
iPSC-MSCs Combined with Low-Dose Rapamycin Induced Islet Allograft Tolerance Through Suppressing Th1 and Enhancing Regulatory T-Cell Differentiation.
Pan-Pan Cheng, Xiao-Cun Liu, +13 authors, Zhong-Quan Qi.
Stem Cells Dev, 2015 Apr 14; 24(15). PMID: 25867817    Free PMC article.
Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+ CD45RB high T Cells into Immunodeficient Mice.
Erin C Steinbach, Gregory R Gipson, Shehzad Z Sheikh.
J Vis Exp, 2015 May 06; (98). PMID: 25938395    Free PMC article.
Experimental Models of Inflammatory Bowel Diseases.
Patricia Kiesler, Ivan J Fuss, Warren Strober.
Cell Mol Gastroenterol Hepatol, 2015 May 23; 1(2). PMID: 26000334    Free PMC article.
Highly Cited.
An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy.
J-S Do, A Visperas, +10 authors, B Min.
Mucosal Immunol, 2015 May 28; 9(1). PMID: 26013006    Free PMC article.
Resident bacteria-stimulated IL-10-secreting B cells ameliorate T cell-mediated colitis by inducing Tr-1 cells that require IL-27-signaling.
Yoshiyuki Mishima, Bo Liu, Jonathan J Hansen, R Balfour Sartor.
Cell Mol Gastroenterol Hepatol, 2015 Jun 03; 1(3). PMID: 26034781    Free PMC article.
In-situ tumor vaccination: Bringing the fight to the tumor.
Robert H Pierce, Jean S Campbell, +2 authors, Holbrook E K Kohrt.
Hum Vaccin Immunother, 2015 Jun 10; 11(8). PMID: 26055074    Free PMC article.
Review.
T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it?
Florian Anzengruber, Pinar Avci, Lucas Freitas de Freitas, Michael R Hamblin.
Photochem Photobiol Sci, 2015 Jun 13; 14(8). PMID: 26062987    Free PMC article.
Combination of Id2 Knockdown Whole Tumor Cells and Checkpoint Blockade: A Potent Vaccine Strategy in a Mouse Neuroblastoma Model.
Lina Chakrabarti, Clifford Morgan, Anthony D Sandler.
PLoS One, 2015 Jun 17; 10(6). PMID: 26079374    Free PMC article.
The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression.
Alfred P See, Jonathon J Parker, Allen Waziri.
J Neurooncol, 2015 Jul 01; 123(3). PMID: 26123363
Review.
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.
Louisa E Jeffery, Omar S Qureshi, +6 authors, David M Sansom.
PLoS One, 2015 Jul 03; 10(7). PMID: 26134669    Free PMC article.
Different aspects of CD4 T cells that lead to viral clearance or persistence of HCV infection.
Kazushi Sugimoto, Katsuya Shiraki.
Hepatol Int, 2012 Jan 01; 6(1). PMID: 26201340
Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective.
Masahiro Ono, Reiko J Tanaka.
Immunol Cell Biol, 2015 Jul 29; 94(1). PMID: 26215792    Free PMC article.
Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells.
Danielle Califano, Jonathan J Cho, +5 authors, Dorina Avram.
Immunity, 2015 Aug 02; 43(2). PMID: 26231117    Free PMC article.
Highly Cited.
Immunomodulation of host-protective immune response by regulating Foxp3 expression and Treg function in Leishmania-infected BALB/c mice: critical role of IRF1.
Bidisha Paul Chowdhury, Shibali Das, +5 authors, Subrata Majumdar.
Pathog Dis, 2015 Aug 25; 73(8). PMID: 26297915    Free PMC article.
Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease.
James D Lord, Donna M Shows, Janice Chen, Richard C Thirlby.
PLoS One, 2015 Aug 26; 10(8). PMID: 26305224    Free PMC article.
Huangqin-Tang Ameliorates TNBS-Induced Colitis by Regulating Effector and Regulatory CD4(+) T Cells.
Ying Zou, Wen-Yang Li, +10 authors, Xue-Bao Zheng.
Biomed Res Int, 2015 Sep 09; 2015. PMID: 26347453    Free PMC article.
Immunosuppression associated with chronic inflammation in the tumor microenvironment.
Dingzhi Wang, Raymond N DuBois.
Carcinogenesis, 2015 Sep 12; 36(10). PMID: 26354776    Free PMC article.
Highly Cited. Review.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M Paterson, Scott B Lovitch, +9 authors, Arlene H Sharpe.
J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185    Free PMC article.
Highly Cited.
Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation.
Niloufar Safinia, Cristiano Scotta, +2 authors, Giovanna Lombardi.
Front Immunol, 2015 Sep 18; 6. PMID: 26379673    Free PMC article.
Review.
Mechanisms of immunological tolerance in central nervous system inflammatory demyelination.
Elisabeth R Mari, Jason N Moore, Guang-Xian Zhang, Abdolmohamad Rostami.
Clin Exp Neuroimmunol, 2015 Oct 02; 6(3). PMID: 26425145    Free PMC article.
Ovarian carcinoma-infiltrating regulatory T cells were more potent suppressors of CD8(+) T cell inflammation than their peripheral counterparts, a function dependent on TIM3 expression.
Meimei Bu, Yizhen Shen, +4 authors, Yan Cai.
Tumour Biol, 2015 Oct 21; 37(3). PMID: 26482613
Promises and paradoxes of regulatory T cells in inflammatory bowel disease.
James D Lord.
World J Gastroenterol, 2015 Nov 03; 21(40). PMID: 26523099    Free PMC article.
Review.
Regulatory T cells in cardiovascular diseases.
Xiao Meng, Jianmin Yang, +6 authors, Yun Zhang.
Nat Rev Cardiol, 2015 Nov 04; 13(3). PMID: 26525543
Highly Cited. Review.
Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells.
Toshiharu Onodera, Atsunori Fukuhara, +6 authors, Iichiro Shimomura.
Sci Rep, 2015 Nov 20; 5. PMID: 26582486    Free PMC article.
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
Gabriela Tejón, Valeria Manríquez, +8 authors, Mario Rosemblatt.
Biomed Res Int, 2015 Nov 20; 2015. PMID: 26583087    Free PMC article.
Clinical relevance of host immunity in breast cancer: from TILs to the clinic.
Peter Savas, Roberto Salgado, +4 authors, Sherene Loi.
Nat Rev Clin Oncol, 2015 Dec 17; 13(4). PMID: 26667975
Highly Cited. Review.
Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.
Niloufar Safinia, Trishan Vaikunthanathan, +9 authors, Giovanna Lombardi.
Oncotarget, 2016 Jan 21; 7(7). PMID: 26788992    Free PMC article.
Highly Cited.
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.
Christophe Pedros, Fanny Duguet, Abdelhadi Saoudi, Marianne Chabod.
World J Gastroenterol, 2016 Jan 27; 22(3). PMID: 26811641    Free PMC article.
Review.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Review.
Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition.
Joanna Brzostek, Nicholas R J Gascoigne, Vasily Rybakin.
Front Immunol, 2016 Feb 13; 7. PMID: 26870040    Free PMC article.
Review.
Ipilimumab (Anti-Ctla-4 Mab) in the treatment of metastatic melanoma: Effectiveness and toxicity management.
Paola Savoia, Chiara Astrua, Paolo Fava.
Hum Vaccin Immunother, 2016 Feb 19; 12(5). PMID: 26889818    Free PMC article.
Review.
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton.
Science, 2016 Mar 05; 351(6280). PMID: 26940869    Free PMC article.
Highly Cited.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.
Matthew M Halpert, Vanaja Konduri, +5 authors, William K Decker.
Stem Cells Dev, 2016 Mar 17; 25(10). PMID: 26979751    Free PMC article.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.
Daniel E Lowther, Brittany A Goods, +10 authors, David A Hafler.
JCI Insight, 2016 May 18; 1(5). PMID: 27182555    Free PMC article.
Highly Cited.
T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.
Thomas Krausgruber, Chris Schiering, +7 authors, Fiona Powrie.
Nat Commun, 2016 May 20; 7. PMID: 27193261    Free PMC article.
Monoclonal regulatory T cells provide insights into T cell suppression.
Céline Gubser, Mathias Schmaler, Simona W Rossi, Ed Palmer.
Sci Rep, 2016 May 24; 6. PMID: 27210828    Free PMC article.
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
Hristina Nedelkovska, Alexander F Rosenberg, +9 authors, Steven H Bernstein.
PLoS One, 2016 May 27; 11(5). PMID: 27228053    Free PMC article.
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.
Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion.
Front Immunol, 2016 Jun 01; 7. PMID: 27242797    Free PMC article.
Review.
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
Xin Li, Nicole V Acuff, +4 authors, Wendy T Watford.
J Biol Chem, 2016 Jun 05; 291(32). PMID: 27261457    Free PMC article.
Phenotypic and functional testing of circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab.
Janet Retseck, Robert VanderWeele, +3 authors, Ahmad A Tarhini.
J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330811    Free PMC article.
Vagotomy affects the development of oral tolerance and increases susceptibility to develop colitis independently of the alpha-7 nicotinic receptor.
Martina Di Giovangiulio, Goele Bosmans, +6 authors, Guy E Boeckxstaens.
Mol Med, 2016 Jun 25; 22. PMID: 27341335    Free PMC article.
Engagement of distinct epitopes on CD43 induces different co-stimulatory pathways in human T cells.
Madhura Modak, Otto Majdic, +7 authors, Johannes Stöckl.
Immunology, 2016 Jul 09; 149(3). PMID: 27392084    Free PMC article.
CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency.
Bernice Lo, Jill M Fritz, +3 authors, Michael J Lenardo.
Blood, 2016 Jul 16; 128(8). PMID: 27418640    Free PMC article.
Review.
Regulatory T Cells: Central Concepts from Ontogeny to Therapy.
Bernard Khor.
Transfus Med Rev, 2016 Aug 16; 31(1). PMID: 27523957    Free PMC article.
Review.
Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviate Intestinal Inflammation in Vivo.
Tzu-Yu Shao, Ling-Hui Hsu, Chien-Hui Chien, Bor-Luen Chiang.
Sci Rep, 2016 Sep 02; 6. PMID: 27581189    Free PMC article.
Regulatory T cells in allergic diseases.
Magali Noval Rivas, Talal A Chatila.
J Allergy Clin Immunol, 2016 Sep 07; 138(3). PMID: 27596705    Free PMC article.
Highly Cited. Review.
Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis.
Yin Zongyi, Chen Dongying, Li Baifeng.
PLoS One, 2016 Sep 10; 11(9). PMID: 27611317    Free PMC article.
Restoring Regulatory T Cells in Type 1 Diabetes.
Allyson Spence, Qizhi Tang.
Curr Diab Rep, 2016 Sep 25; 16(11). PMID: 27664043
Review.
An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy.
Chie Miyabe, Yoshishige Miyabe, +4 authors, Sebastian Unizony.
Ann Rheum Dis, 2016 Dec 09; 76(5). PMID: 27927642    Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors.
Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim.
Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545    Free PMC article.
Review.
CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway.
Pablo Penaloza-MacMaster.
Immunology, 2017 Apr 05; 151(2). PMID: 28375543    Free PMC article.
Review.
The Protective Role of Type I Interferons in the Gastrointestinal Tract.
Kevin P Kotredes, Brianna Thomas, Ana M Gamero.
Front Immunol, 2017 Apr 22; 8. PMID: 28428788    Free PMC article.
Review.
Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.
Toshiki Eri, Kimito Kawahata, +10 authors, Kazuhiko Yamamoto.
Sci Rep, 2017 Apr 27; 7. PMID: 28443628    Free PMC article.
Dinitrophenyl hapten with laser immunotherapy for advanced malignant melanoma: A clinical study.
Dian-Jun Chen, Xiao-Song Li, +8 authors, Wei-R Chen.
Oncol Lett, 2017 Apr 30; 13(3). PMID: 28454272    Free PMC article.
Ceramide synthesis regulates T cell activity and GVHD development.
M Hanief Sofi, Jessica Heinrichs, +14 authors, Xue-Zhong Yu.
JCI Insight, 2017 May 19; 2(10). PMID: 28515365    Free PMC article.
Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.
Rebecca L Crepeau, Mandy L Ford.
Expert Opin Biol Ther, 2017 May 21; 17(8). PMID: 28525959    Free PMC article.
Review.
Rituximab in Minimal Change Disease: Mechanisms of Action and Hypotheses for Future Studies.
Nima Madanchi, Martin Bitzan, Tomoko Takano.
Can J Kidney Health Dis, 2017 May 26; 4. PMID: 28540057    Free PMC article.
Review.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
Hwei-Fang Tsai, Ping-Ning Hsu.
J Biomed Sci, 2017 May 27; 24(1). PMID: 28545567    Free PMC article.
Review.
Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function.
Alexandre Bignon, Alan P Watt, Michelle A Linterman.
Front Immunol, 2017 May 31; 8. PMID: 28555139    Free PMC article.
Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy.
Jingyu Zhang, Dai Liu, +4 authors, Jennifer D Wu.
Sci Adv, 2017 Jun 01; 3(5). PMID: 28560327    Free PMC article.
Regulatory T Cells in Allergy and Asthma.
Elena Martín-Orozco, María Norte-Muñoz, Javier Martínez-García.
Front Pediatr, 2017 Jun 08; 5. PMID: 28589115    Free PMC article.
Review.
Regulatory T cells in multiple sclerosis and myasthenia gravis.
K M Danikowski, S Jayaraman, B S Prabhakar.
J Neuroinflammation, 2017 Jun 11; 14(1). PMID: 28599652    Free PMC article.
Highly Cited. Review.
Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations.
N Verma, S O Burns, L S K Walker, D M Sansom.
Clin Exp Immunol, 2017 Jun 11; 190(1). PMID: 28600865    Free PMC article.
Review.
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Josiane Lilian Dos Santos Schiavinato, Rodrigo Haddad, +6 authors, Rodrigo Alexandre Panepucci.
Sci Rep, 2017 Jun 18; 7(1). PMID: 28620241    Free PMC article.
D-mannose induces regulatory T cells and suppresses immunopathology.
Dunfang Zhang, Cheryl Chia, +11 authors, WanJun Chen.
Nat Med, 2017 Aug 02; 23(9). PMID: 28759052
Tremelimumab-Induced Graves Hyperthyroidism.
Earn H Gan, Anna L Mitchell, +2 authors, Petros Perros.
Eur Thyroid J, 2017 Aug 09; 6(3). PMID: 28785544    Free PMC article.
Regulatory T cells in acute and chronic kidney diseases.
Rahul Sharma, Gilbert R Kinsey.
Am J Physiol Renal Physiol, 2017 Sep 08; 314(5). PMID: 28877881    Free PMC article.
Review.
Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+ and CD8+CD122+PD1+ regulatory T cells.
Yeshu Wang, Qingfeng Xie, +2 authors, Zhenhua Dai.
Oncotarget, 2017 Sep 28; 8(36). PMID: 28947964    Free PMC article.
Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway.
Songwen Ju, Yan Ge, +4 authors, Songguang Ju.
Cell Cycle, 2017 Oct 05; 17(1). PMID: 28976231    Free PMC article.
Potential Role of Vδ2+ γδ T Cells in Regulation of Immune Activation in Primary HIV Infection.
Nupur Bhatnagar, Pierre-Marie Girard, +9 authors, ANRS EP-56 Group.
Front Immunol, 2017 Oct 11; 8. PMID: 28993778    Free PMC article.
CCDC88B is required for pathogenesis of inflammatory bowel disease.
Nassima Fodil, Neda Moradin, +17 authors, Philippe Gros.
Nat Commun, 2017 Oct 17; 8(1). PMID: 29030607    Free PMC article.
CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.
Colleen S McGary, Claire Deleage, +14 authors, Mirko Paiardini.
Immunity, 2017 Oct 19; 47(4). PMID: 29045906    Free PMC article.
Highly Cited.
Incidence of immune checkpoint inhibitor-related colitis in solid tumor patients: A systematic review and meta-analysis.
Daniel Y Wang, Fei Ye, Shilin Zhao, Douglas B Johnson.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123955    Free PMC article.
A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection.
Feifei Qiu, Huazhen Liu, +2 authors, Zhenhua Dai.
Front Immunol, 2017 Nov 24; 8. PMID: 29167674    Free PMC article.
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Mo Xu, Maria Pokrovskii, +7 authors, Dan R Littman.
Nature, 2018 Feb 08; 554(7692). PMID: 29414937    Free PMC article.
Highly Cited.
FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis.
Manolo Sambucci, Francesca Gargano, +9 authors, Giovanna Borsellino.
Sci Rep, 2018 Mar 01; 8(1). PMID: 29487369    Free PMC article.
Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management.
Mark A Samaan, Polychronis Pavlidis, +2 authors, Peter M Irving.
Nat Rev Gastroenterol Hepatol, 2018 Mar 08; 15(4). PMID: 29512649
Review.
Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.
Mohamed B Ezzelarab, Lien Lu, +2 authors, Angus W Thomson.
Front Immunol, 2018 Mar 10; 9. PMID: 29520267    Free PMC article.
Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells.
Niloufar Safinia, Nathali Grageda, +5 authors, Giovanna Lombardi.
Front Immunol, 2018 Mar 15; 9. PMID: 29535728    Free PMC article.
Review.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada.
Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375    Free PMC article.
Highly Cited.
An endogenous aryl hydrocarbon receptor ligand, ITE, induces regulatory T cells and ameliorates experimental colitis.
Jessica D Abron, Narendra P Singh, +4 authors, Udai P Singh.
Am J Physiol Gastrointest Liver Physiol, 2018 Apr 20; 315(2). PMID: 29672155    Free PMC article.
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
Charlotte Schwab, Annemarie Gabrysch, +78 authors, Bodo Grimbacher.
J Allergy Clin Immunol, 2018 May 08; 142(6). PMID: 29729943    Free PMC article.
Highly Cited.
ImmTAC/Anti-PD-1 antibody combination to enhance killing of cancer cells by reversing regulatory T-cell-mediated immunosuppression.
Huanling Zhang, Yanyan Li, +9 authors, Yi Li.
Immunology, 2018 May 24; 155(2). PMID: 29791021    Free PMC article.
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study.
Ethan M Shevach.
Front Immunol, 2018 Jun 06; 9. PMID: 29868011    Free PMC article.
Highly Cited. Review.
Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma.
Janet Retseck, Alexis Nasr, +4 authors, Ahmad A Tarhini.
J Transl Med, 2018 Jul 06; 16(1). PMID: 29973204    Free PMC article.
Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response.
Krista Stockenhuber, Ahmed N Hegazy, +9 authors, Fiona Powrie.
J Exp Med, 2018 Jul 08; 215(8). PMID: 29980582    Free PMC article.
Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation.
Yuli Cheng, Xing Zhu, +6 authors, Xinping Zhu.
Front Immunol, 2018 Aug 11; 9. PMID: 30093899    Free PMC article.
Regulatory T cells and asthma.
Sheng-Tao Zhao, Chang-Zheng Wang.
J Zhejiang Univ Sci B, 2018 Sep 05; 19(9). PMID: 30178633    Free PMC article.
Review.
Characterization of CTLA4 Trafficking and Implications for Its Function.
Sahamoddin Khailaie, Behzad Rowshanravan, +6 authors, Michael Meyer-Hermann.
Biophys J, 2018 Sep 17; 115(7). PMID: 30219287    Free PMC article.
Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy.
Jiawei Tu, Hui Zhang, +2 authors, Zhiyi Chen.
Onco Targets Ther, 2018 Sep 27; 11. PMID: 30254469    Free PMC article.
Review.
Adoptive Transfers of CD4+CD25+ Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis.
Kai Wang, Tongjia Zhu, +5 authors, Guixue Hu.
Biomed Res Int, 2018 Oct 27; 2018. PMID: 30364052    Free PMC article.
Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice.
Ju-Hyun An, Woo-Jin Song, +7 authors, Hwa-Young Youn.
BMC Vet Res, 2018 Nov 21; 14(1). PMID: 30453939    Free PMC article.
Tolerogenic Dendritic Cells Attenuate Experimental Autoimmune Antimyeloperoxidase Glomerulonephritis.
Dragana Odobasic, Virginie Oudin, +3 authors, Stephen R Holdsworth.
J Am Soc Nephrol, 2019 Aug 25; 30(11). PMID: 31444274    Free PMC article.
Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression.
Chloé Laplagne, Marcin Domagala, +7 authors, Mary Poupot.
Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31547627    Free PMC article.
Review.
The Colon as a Major Site of Immunoregulation by CD4+ T Cell Subsets in the Steady State.
Alan Sher, Brian L Kelsall.
J Immunol, 2019 Sep 26; 203(7). PMID: 31551399    Free PMC article.
Review.
Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation.
Atika Dhar, Meenakshi Chawla, +8 authors, Soumen Basak.
Sci Rep, 2019 Sep 27; 9(1). PMID: 31554891    Free PMC article.
Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.
Martina Di Giovangiulio, Angelamaria Rizzo, +8 authors, Massimo C Fantini.
Front Immunol, 2019 Oct 02; 10. PMID: 31572375    Free PMC article.
The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma.
Peng Liao, Haofan Wang, +2 authors, Xin-Hua Liang.
Front Immunol, 2019 Nov 12; 10. PMID: 31708918    Free PMC article.
Review.
Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis.
Amrollah Sharifi, Homayoon Vahedi, +4 authors, Mohammad Javad Hosseinzadeh-Attar.
Middle East J Dig Dis, 2019 Dec 12; 11(4). PMID: 31824622    Free PMC article.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
Review.
CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation.
Antonella Mancusi, Sara Piccinelli, Andrea Velardi, Antonio Pierini.
Front Immunol, 2020 Jan 11; 10. PMID: 31921162    Free PMC article.
Review.
Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms.
Petros Fessas, Lucia A Possamai, +5 authors, David J Pinato.
Immunology, 2019 Oct 28; 159(2). PMID: 31646612    Free PMC article.
Review.
Antigen-specific in vitro expansion of factor VIII-specific regulatory T cells induces tolerance in hemophilia A mice.
Bryn M Smith, Meghan J Lyle, Alex C Chen, Carol H Miao.
J Thromb Haemost, 2019 Oct 15; 18(2). PMID: 31609041    Free PMC article.
Costimulation Blockade in Kidney Transplant Recipients.
Marieke van der Zwan, Dennis A Hesselink, Martijn W F van den Hoogen, Carla C Baan.
Drugs, 2019 Nov 22; 80(1). PMID: 31749062    Free PMC article.
Review.
Stromal Vascular Fraction and its Role in the Management of Alopecia: A Review.
Athanasios J Stefanis, Tomas Groh, +2 authors, Peter O Bauer.
J Clin Aesthet Dermatol, 2020 Feb 11; 12(11). PMID: 32038756    Free PMC article.
Review.
Dissecting the Heterogeneity in T-Cell Mediated Inflammation in IBD.
Irma Tindemans, Maria E Joosse, Janneke N Samsom.
Cells, 2020 Jan 08; 9(1). PMID: 31906479    Free PMC article.
Review.
Humanized mouse models of genetic immune disorders and hematological malignancies.
Rajeev K Tyagi, Jing Li, +3 authors, Jeremy A Goettel.
Biochem Pharmacol, 2019 Oct 22; 174. PMID: 31634456    Free PMC article.
Review.
Fibrogenesis in Chronic DSS Colitis is Not Influenced by Neutralisation of Regulatory T Cells, of Major T Helper Cytokines or Absence of IL-13.
Brecht Creyns, Jonathan Cremer, +7 authors, Christine Breynaert.
Sci Rep, 2019 Jul 13; 9(1). PMID: 31296924    Free PMC article.
Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target.
Neda Mousavi-Niri, Maryam Naseroleslami, Jamshid Hadjati.
Hum Vaccin Immunother, 2019 Jan 12; 15(3). PMID: 30633616    Free PMC article.
Review.
A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory response in experimental colitis.
V B Freitas Alves, B Coutinho de Sousa, +9 authors, C Ribeiro Cardoso.
Clin Exp Immunol, 2019 Jan 22; 196(2). PMID: 30663040    Free PMC article.
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells.
Jessica Bourque, Daniel Hawiger.
Crit Rev Immunol, 2019 Feb 23; 38(5). PMID: 30792568    Free PMC article.
Highly Cited. Review.
Meglumine acridone acetate, the ionic salt of CMA and N-methylglucamine, induces apoptosis in human PBMCs via the mitochondrial pathway.
Marina A Plotnikova, Sergey A Klotchenko, +7 authors, Andrey V Vasin.
Sci Rep, 2019 Dec 05; 9(1). PMID: 31796757    Free PMC article.
Defects of CTLA-4 Are Associated with Regulatory T Cells in Myasthenia Gravis Implicated by Intravenous Immunoglobulin Therapy.
Wenhua Xu, Mingshan Ren, +5 authors, Jiajun Cui.
Mediators Inflamm, 2020 Mar 10; 2020. PMID: 32148437    Free PMC article.
Workup and Management of Immune-Mediated Colitis in Patients Treated with Immune Checkpoint Inhibitors.
Bhavana Pendurthi Singh, John L Marshall, Aiwu Ruth He.
Oncologist, 2020 Mar 13; 25(3). PMID: 32162824    Free PMC article.
Review.
CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation.
Xiaojing Wang, Weiming Yan, +11 authors, Qin Ning.
Cell Immunol, 2012 Dec 25; 280(1). PMID: 23261832    Free PMC article.
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice.
Chieko Tashita, Masato Hoshi, +8 authors, Kuniaki Saito.
World J Gastroenterol, 2020 Mar 25; 26(9). PMID: 32206003    Free PMC article.
Immunosuppressive mechanisms during viral infectious diseases.
Ghanashyam Sarikonda, Matthias G von Herrath.
Methods Mol Biol, 2010 Oct 14; 677. PMID: 20941625    Free PMC article.
A causal link between lymphopenia and autoimmunity.
Alexander Khoruts, Joanne M Fraser.
Immunol Lett, 2005 Mar 26; 98(1). PMID: 15790505    Free PMC article.
Review.
Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant.
Varun Dwivedi, Cordelia Manickam, +5 authors, Gourapura J Renukaradhya.
Vaccine, 2011 Mar 23; 29(23). PMID: 21419162    Free PMC article.
Development of immune checkpoint therapy for cancer.
Jill M Fritz, Michael J Lenardo.
J Exp Med, 2019 May 10; 216(6). PMID: 31068379    Free PMC article.
Highly Cited. Review.
IL-21 Induces an Imbalance of Th17/Treg Cells in Moderate-to-Severe Plaque Psoriasis Patients.
Yuling Shi, Zeyu Chen, +5 authors, Jun Gu.
Front Immunol, 2019 Aug 24; 10. PMID: 31440249    Free PMC article.
Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells.
Andreas von Knethen, Ulrike Heinicke, +2 authors, Bernhard Brüne.
Int J Mol Sci, 2020 Apr 03; 21(7). PMID: 32235291    Free PMC article.
Review.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
Review.
Regulatory T cells in Crohn's disease following anti-TNF-α therapy.
Toshimi Chiba, Mikiya Endo, +4 authors, Takayuki Matsumoto.
JGH Open, 2020 Jun 10; 4(3). PMID: 32514440    Free PMC article.
Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review.
Xueyan Ding, Peng Bin, +2 authors, Guoqiang Zhu.
Mediators Inflamm, 2020 Jul 04; 2020. PMID: 32617076    Free PMC article.
Review.
Maternal and fetal T cells in term pregnancy and preterm labor.
Derek Miller, Meyer Gershater, +2 authors, Nardhy Gomez-Lopez.
Cell Mol Immunol, 2020 May 30; 17(7). PMID: 32467619    Free PMC article.
Review.
Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.
Diwakar Davar, Hassane M Zarour.
Methods Mol Biol, 2019 Sep 11; 2055. PMID: 31502146    Free PMC article.
Review.
Cytokines and costimulation in acute graft-versus-host disease.
Geoffrey R Hill, Motoko Koyama.
Blood, 2020 Jun 12; 136(4). PMID: 32526028    Free PMC article.
Review.
Identification of Novel Molecular Markers of Human Th17 Cells.
Anna Sałkowska, Kaja Karaś, +5 authors, Marcin Ratajewski.
Cells, 2020 Jul 09; 9(7). PMID: 32635226    Free PMC article.
Research Progress and Existing Problems for Abscopal Effect.
Di Wang, Xia Zhang, +6 authors, Jinming Yu.
Cancer Manag Res, 2020 Aug 18; 12. PMID: 32801902    Free PMC article.
Review.
BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations.
Tao Shen, Shengnan Jia, +4 authors, Liping Cao.
iScience, 2020 Aug 18; 23(8). PMID: 32798974    Free PMC article.
Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers.
Carmen Tse, Ashleigh Warner, Rufaik Farook, James G Cronin.
Biomolecules, 2020 Aug 01; 10(8). PMID: 32731620    Free PMC article.
Review.
Induction of CD4+CD25+ Regulatory T Cells from In Vitro Grown Human Mononuclear Cells by Sparteine Sulfate and Harpagoside.
Nour Z Atwany, Seyedeh-Khadijeh Hashemi, +3 authors, Mona Rushdi Hassuneh.
Biology (Basel), 2020 Aug 13; 9(8). PMID: 32781652    Free PMC article.
Immune checkpoint inhibitor-induced colitis: A comprehensive review.
Aniruddh Som, Rohan Mandaliya, +4 authors, Mark C Mattar.
World J Clin Cases, 2019 Mar 08; 7(4). PMID: 30842952    Free PMC article.
Highly Cited. Review.
The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations.
Nilofer Sorathia, Hussein Al-Rubaye, Benham Zal.
Eur Cardiol, 2019 Jul 31; 14(2). PMID: 31360235    Free PMC article.
Review.
The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas.
Luka de Vos, Ingela Grünwald, +7 authors, Dimo Dietrich.
Epigenetics, 2020 Apr 14; 15(11). PMID: 32281488    Free PMC article.
Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.
S C Sasson, J J Zaunders, +17 authors, A D Kelleher.
Clin Exp Immunol, 2020 Aug 01; 202(3). PMID: 32734627    Free PMC article.
Ipilimumab in prostate cancer.
Nishith Singh, Ravi A Madan, James L Gulley.
Expert Opin Biol Ther, 2012 Dec 26; 13(2). PMID: 23265575    Free PMC article.
Review.
Human CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism.
Jessica R Magid-Bernstein, Christine M Rohowsky-Kochan.
J Interferon Cytokine Res, 2017 Apr 08; 37(4). PMID: 28387597    Free PMC article.
JunB regulates homeostasis and suppressive functions of effector regulatory T cells.
Shin-Ichi Koizumi, Daiki Sasaki, +8 authors, Hiroki Ishikawa.
Nat Commun, 2018 Dec 19; 9(1). PMID: 30559442    Free PMC article.
Top-100 highest-cited original articles in inflammatory bowel disease: A bibliometric analysis.
Xinrong Chen, Kun Yang, Yujie Xu, Ka Li.
Medicine (Baltimore), 2019 May 18; 98(20). PMID: 31096525    Free PMC article.
Constitutive reduction in the checkpoint inhibitor, CTLA-4, does not accelerate SLE in NZM 2328 mice.
William Stohl, Ning Yu, +2 authors, Chaim O Jacob.
Lupus Sci Med, 2019 Jun 07; 6(1). PMID: 31168399    Free PMC article.
Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma.
Mohamed A Abd El Aziz, Antonio Facciorusso, +4 authors, Rodolfo Sacco.
Vaccines (Basel), 2020 Oct 23; 8(4). PMID: 33086471    Free PMC article.
Review.
CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4.
Neil Halliday, Cayman Williams, +9 authors, David M Sansom.
Front Immunol, 2020 Dec 29; 11. PMID: 33363541    Free PMC article.
Discovery and Function of B-Cell IgD Low (BDL) B Cells in Immune Tolerance.
Mohamed I Khalil, Cody J Gurski, +2 authors, Bonnie N Dittel.
J Mol Biol, 2020 Jul 03; 433(1). PMID: 32615130    Free PMC article.
Review.
Cancer-associated adipocytes as immunomodulators in cancer.
Qi Wu, Bei Li, +3 authors, Shengrong Sun.
Biomark Res, 2021 Jan 09; 9(1). PMID: 33413697    Free PMC article.
Review.
Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.
Jacobo López-Abente, Marta Martínez-Bonet, +9 authors, Rafael Correa-Rocha.
Sci Rep, 2021 Jan 14; 11(1). PMID: 33436905    Free PMC article.
MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice.
John E Schjenken, Lachlan M Moldenhauer, +6 authors, Sarah A Robertson.
Mucosal Immunol, 2020 Jan 29; 13(4). PMID: 31988469
CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis.
Blagoje Soskic, Louisa E Jeffery, +8 authors, David M Sansom.
Front Immunol, 2021 Jan 26; 11. PMID: 33488578    Free PMC article.
Intestinal Regulatory T Cells.
Vanessa R Figliuolo da Paz, Deepa R Jamwal, Pawel R Kiela.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523448
Influence of pentoxifylline on gene expression of PAG1/ miR-1206/ SNHG14 in ischemic heart disease.
Ahlam Abd El-Aziz, Mohamed Ali El-Desouky, +2 authors, Amr Mohamed Abdelmoniem.
Biochem Biophys Rep, 2021 Feb 09; 25. PMID: 33553684    Free PMC article.
Systemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells.
Eun Jee Kim, Joon Ye Kim, +6 authors, Beom Seok Kim.
Yonsei Med J, 2021 Feb 03; 62(2). PMID: 33527793    Free PMC article.
Modulation of regulatory T cell function and stability by co-inhibitory receptors.
Liliana E Lucca, Margarita Dominguez-Villar.
Nat Rev Immunol, 2020 Apr 10; 20(11). PMID: 32269380
Review.
Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.
Long Hang, Sangeeta Kumar, +3 authors, Joel V Weinstock.
J Immunol, 2019 Mar 10; 202(8). PMID: 30850474    Free PMC article.
Regulatory T cells in ischemic stroke.
Hong-Yun Wang, Jun-Rui Ye, +2 authors, Nai-Hong Chen.
Acta Pharmacol Sin, 2021 Mar 28; 43(1). PMID: 33772140    Free PMC article.
Review.
Regulatory T Cell-Enhancing Therapies to Treat Atherosclerosis.
Hafid Ait-Oufella, Jean-Rémi Lavillegrand, Alain Tedgui.
Cells, 2021 Apr 04; 10(4). PMID: 33805071    Free PMC article.
Review.
Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications.
Yi Dong, Cuiping Yang, Fan Pan.
Front Immunol, 2021 Apr 30; 12. PMID: 33912156    Free PMC article.
Review.
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
Caleb R Glassman, Leon Su, +16 authors, K Christopher Garcia.
Elife, 2021 May 19; 10. PMID: 34003116    Free PMC article.
HIV persistence in subsets of CD4+ T cells: 50 shades of reservoirs.
Rémi Fromentin, Nicolas Chomont.
Semin Immunol, 2020 Dec 05; 51. PMID: 33272901    Free PMC article.
Review.
Treg: A Promising Immunotherapeutic Target in Oral Diseases.
Yujing Zhang, Jihua Guo, Rong Jia.
Front Immunol, 2021 Jun 29; 12. PMID: 34177907    Free PMC article.
Review.
Harnessing Mechanisms of Immune Tolerance to Improve Outcomes in Solid Organ Transplantation: A Review.
Priscila Ferreira Slepicka, Mahboubeh Yazdanifar, Alice Bertaina.
Front Immunol, 2021 Jun 29; 12. PMID: 34177941    Free PMC article.
Review.
Multipotent adult progenitor cells induce regulatory T cells and promote their suppressive phenotype via TGFβ and monocyte-dependent mechanisms.
Alice Valentin-Torres, Cora Day, +5 authors, Anthony E Ting.
Sci Rep, 2021 Jul 02; 11(1). PMID: 34193955    Free PMC article.
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells.
Murat Tekguc, James Badger Wing, +2 authors, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2021 Jul 25; 118(30). PMID: 34301886    Free PMC article.
Emerging Cellular Therapies for Anti-myeloperoxidase Vasculitis and Other Autoimmune Diseases.
Dragana Odobasic, Stephen R Holdsworth.
Front Immunol, 2021 Aug 17; 12. PMID: 34394071    Free PMC article.
Review.
Toll-like receptor-4 null mutation causes fetal loss and fetal growth restriction associated with impaired maternal immune tolerance in mice.
Hon Y Chan, Lachlan M Moldenhauer, +2 authors, Sarah A Robertson.
Sci Rep, 2021 Aug 18; 11(1). PMID: 34400677    Free PMC article.
Dysfunctions, Molecular Mechanisms, and Therapeutic Strategies of Regulatory T Cells in Rheumatoid Arthritis.
Xiaoya Li, Huihui Xu, +4 authors, Cheng Xiao.
Front Pharmacol, 2021 Sep 14; 12. PMID: 34512345    Free PMC article.
Review.
Bowel Histology of CVID Patients Reveals Distinct Patterns of Mucosal Inflammation.
Cornelia M van Schewick, David M Lowe, +7 authors, Bodo Grimbacher.
J Clin Immunol, 2021 Oct 03; 42(1). PMID: 34599484    Free PMC article.
Gut microbiome and checkpoint inhibitor colitis.
Kanika Sehgal, Sahil Khanna.
Intest Res, 2020 Nov 30; 19(4). PMID: 33249800    Free PMC article.
Review.
Increased Frequency of CTLA-4 and PD-1 Expressing Regulatory T Cells and Basophils With an Activating Profile in Infants With Moderate-to-Severe Atopic Dermatitis Hypersensitized to Food Allergens.
Agurtzane Bilbao, Raquel Pérez-Garay, +6 authors, Olatz Zenarruzabeitia.
Front Pediatr, 2021 Dec 17; 9. PMID: 34912758    Free PMC article.
Early Myeloid Derived Suppressor Cells (eMDSCs) Are Associated With High Donor Myeloid Chimerism Following Haploidentical HSCT for Sickle Cell Disease.
Deepali K Bhat, Purevdorj B Olkhanud, +11 authors, Courtney D Fitzhugh.
Front Immunol, 2021 Dec 18; 12. PMID: 34917079    Free PMC article.
Genetic Variants Assessing Crohn's Disease Pattern in Pediatric Inflammatory Bowel Disease Patients by a Clinical Exome Survey.
Dago Dougba Noel, Pinelli Marinella, +9 authors, Badolato Raffaele.
Bioinform Biol Insights, 2022 Jan 11; 15. PMID: 35002226    Free PMC article.
The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation.
Lisa Sandner, Marlis Alteneder, +11 authors, Nicole Boucheron.
Front Immunol, 2022 Jan 11; 12. PMID: 35003062    Free PMC article.
Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects.
Shahrokh Abdolahi, Maryam Hosseini, +8 authors, Kaveh Baghaei.
Infect Genet Evol, 2022 Jan 10; 98. PMID: 34999004    Free PMC article.
Ethanol Intoxication and Burn Injury Increases Intestinal Regulatory T Cell Population and Regulatory T Cell Suppressive Capability.
Marisa E Luck, Xiaoling Li, Caroline J Herrnreiter, Mashkoor A Choudhry.
Shock, 2021 Sep 06; 57(2). PMID: 34482318    Free PMC article.
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients.
Yifan Hu, Youdong Chen, +9 authors, Yuling Shi.
Front Cell Dev Biol, 2022 Feb 22; 9. PMID: 35186952    Free PMC article.
Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.
Mukesh K Sriwastva, Zhong-Bin Deng, +14 authors, Huang-Ge Zhang.
EMBO Rep, 2022 Jan 08; 23(3). PMID: 34994476    Free PMC article.
Key Players of the Immunosuppressive Tumor Microenvironment and Emerging Therapeutic Strategies.
Kevin Park, Mysore S Veena, Daniel Sanghoon Shin.
Front Cell Dev Biol, 2022 Mar 30; 10. PMID: 35345849    Free PMC article.
Review.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
Review.
Immune checkpoint inhibitors for the treatment of melanoma.
Francesco Sabbatino, Luigi Liguori, Stefano Pepe, Soldano Ferrone.
Expert Opin Biol Ther, 2022 Feb 09; 22(5). PMID: 35130816    Free PMC article.
Review.
Pregnancy and Tumour: The Parallels and Differences in Regulatory T Cells.
Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal.
Front Immunol, 2022 May 03; 13. PMID: 35493450    Free PMC article.
Review.
Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease.
Sara Bolivar-Wagers, Jemma H Larson, Sujeong Jin, Bruce R Blazar.
Front Immunol, 2022 May 03; 13. PMID: 35493508    Free PMC article.
Review.
Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients.
Emma J West, Karen J Scott, +11 authors, Adel Samson.
Cancers (Basel), 2022 May 15; 14(9). PMID: 35565310    Free PMC article.
Moving to the Outskirts: Interplay Between Regulatory T Cells and Peripheral Tissues.
Anna Estrada Brull, Camilla Panetti, Nicole Joller.
Front Immunol, 2022 May 17; 13. PMID: 35572535    Free PMC article.
Review.
LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism.
Raki Sudan, Sandra Fernandes, +5 authors, William G Kerr.
Front Immunol, 2022 May 24; 13. PMID: 35603158    Free PMC article.
The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.
Di Wu, Haomin Li, +2 authors, Yi Sun.
Nat Commun, 2022 Jun 01; 13(1). PMID: 35641500