Journal Article
. 2000 Jul; 192(2):303-10.
doi: 10.1084/jem.192.2.303.

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4

T Takahashi 1 T Tagami  S Yamazaki  T Uede  J Shimizu  N Sakaguchi  T W Mak  S Sakaguchi  
  • PMID: 10899917
  •     30 References
  •     673 citations


This report shows that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a key role in T cell-mediated dominant immunologic self-tolerance. In vivo blockade of CTLA-4 for a limited period in normal mice leads to spontaneous development of chronic organ-specific autoimmune diseases, which are immunopathologically similar to human counterparts. In normal naive mice, CTLA-4 is constitutively expressed on CD25(+)CD4(+) T cells, which constitute 5-10% of peripheral CD4(+) T cells. When the CD25(+)CD4(+) T cells are stimulated via the T cell receptor in vitro, they potently suppress antigen-specific and polyclonal activation and proliferation of other T cells, including CTLA-4-deficient T cells, and blockade of CTLA-4 abrogates the suppression. CD28-deficient CD25(+)CD4(+) T cells can also suppress normal T cells, indicating that CD28 is dispensable for activation of the regulatory T cells. Thus, the CD25(+)CD4(+) regulatory T cell population engaged in dominant self-tolerance may require CTLA-4 but not CD28 as a costimulatory molecule for its functional activation. Furthermore, interference with this role of CTLA-4 suffices to elicit autoimmune disease in otherwise normal animals, presumably through affecting CD25(+)CD4(+) T cell-mediated control of self-reactive T cells. This unique function of CTLA-4 could be exploited to potentiate T cell-mediated immunoregulation, and thereby to induce immunologic tolerance or to control autoimmunity.

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Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases.
Sharon M Wahl, Wanjun Chen.
Arthritis Res Ther, 2005 Mar 04; 7(2). PMID: 15743491    Free PMC article.
The role of the T cell in autoimmune inflammation.
Alla Skapenko, Jan Leipe, Peter E Lipsky, Hendrik Schulze-Koops.
Arthritis Res Ther, 2005 Apr 19; 7 Suppl 2. PMID: 15833146    Free PMC article.
Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease.
Yoshihisa Yamano, Norihiro Takenouchi, +5 authors, Steven Jacobson.
J Clin Invest, 2005 May 03; 115(5). PMID: 15864353    Free PMC article.
Regulatory T cells in rheumatoid arthritis.
Jan Leipe, Alla Skapenko, Peter E Lipsky, Hendrik Schulze-Koops.
Arthritis Res Ther, 2005 May 19; 7(3). PMID: 15899057    Free PMC article.
Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice.
Ramireddy Bommireddy, Sandra J Engle, +3 authors, Thomas Doetschman.
Cell Immunol, 2005 Jun 01; 232(1-2). PMID: 15922720    Free PMC article.
Activated CD4+ CD25+ T cells suppress antigen-specific CD4+ and CD8+ T cells but induce a suppressive phenotype only in CD4+ T cells.
Detlef Dieckmann, Heidi Plöttner, Stefanie Dotterweich, Gerold Schuler.
Immunology, 2005 Jun 11; 115(3). PMID: 15946248    Free PMC article.
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.
Hisashi Bashuda, Masaaki Kimikawa, +6 authors, Ko Okumura.
J Clin Invest, 2005 Jun 14; 115(7). PMID: 15951837    Free PMC article.
A peripheral circulating compartment of natural naive CD4 Tregs.
Danila Valmori, Andrea Merlo, +2 authors, Maha Ayyoub.
J Clin Invest, 2005 Jul 12; 115(7). PMID: 16007258    Free PMC article.
Highly Cited.
Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells.
Badiga Venkata Aruna, Michael Sela, Edna Mozes.
Proc Natl Acad Sci U S A, 2005 Jul 15; 102(29). PMID: 16014414    Free PMC article.
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.
Niklas Beyersdorf, Stefanie Gaupp, +7 authors, Ralf Gold.
J Exp Med, 2005 Aug 03; 202(3). PMID: 16061730    Free PMC article.
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.
Peter Attia, Giao Q Phan, +14 authors, Steven A Rosenberg.
J Clin Oncol, 2005 Aug 10; 23(25). PMID: 16087944    Free PMC article.
Highly Cited.
Function of tumor necrosis factor receptor family members on regulatory T-cells.
Robert H Arch.
Immunol Res, 2005 Aug 18; 32(1-3). PMID: 16106056
Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
K Inagaki-Ohara, A Sasaki, +7 authors, A Yoshimura.
Gut, 2005 Aug 27; 55(2). PMID: 16120757    Free PMC article.
Pathological role of IL-6 in the experimental allergic bronchial asthma in mice.
Aysefa Doganci, Kerstin Sauer, Roman Karwot, Susetta Finotto.
Clin Rev Allergy Immunol, 2005 Sep 01; 28(3). PMID: 16129910
CD4+ regulatory cells as a potential immunotherapy.
Zoltán Fehérvari, Shimon Sakaguchi.
Philos Trans R Soc Lond B Biol Sci, 2005 Sep 09; 360(1461). PMID: 16147529    Free PMC article.
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.
Masayuki Sho, Koji Kishimoto, +8 authors, David M Rothstein.
Proc Natl Acad Sci U S A, 2005 Sep 10; 102(37). PMID: 16150717    Free PMC article.
Co-stimulatory blockade as therapy for rheumatoid arthritis.
Sarah L Mackie, Edward M Vital, Frederique Ponchel, Paul Emery.
Curr Rheumatol Rep, 2005 Sep 22; 7(5). PMID: 16174492
Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44.
Mihail Firan, Sohita Dhillon, Pila Estess, Mark H Siegelman.
Blood, 2005 Sep 24; 107(2). PMID: 16179372    Free PMC article.
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation.
François Ghiringhelli, Pierre E Puig, +7 authors, Laurence Zitvogel.
J Exp Med, 2005 Sep 28; 202(7). PMID: 16186184    Free PMC article.
Highly Cited.
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.
Kuibeom Ko, Sayuri Yamazaki, +7 authors, Shimon Sakaguchi.
J Exp Med, 2005 Sep 28; 202(7). PMID: 16186187    Free PMC article.
Highly Cited.
Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma.
Peter Attia, Ajay V Maker, +2 authors, Steven A Rosenberg.
J Immunother, 2005 Oct 15; 28(6). PMID: 16224276    Free PMC article.
Genetic control of thymic development of CD4+CD25+FoxP3+ regulatory T lymphocytes.
Paola Romagnoli, Julie Tellier, Joost P M van Meerwijk.
Eur J Immunol, 2005 Nov 01; 35(12). PMID: 16259008    Free PMC article.
Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes.
Roberto Mallone, Gerald T Nepom.
Am J Ther, 2005 Nov 11; 12(6). PMID: 16280647    Free PMC article.
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study.
Ajay V Maker, Giao Q Phan, +11 authors, Steven A Rosenberg.
Ann Surg Oncol, 2005 Nov 12; 12(12). PMID: 16283570    Free PMC article.
Highly Cited.
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade.
Ajay V Maker, Peter Attia, Steven A Rosenberg.
J Immunol, 2005 Nov 23; 175(11). PMID: 16301685    Free PMC article.
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.
Mojgan Ahmadzadeh, Steven A Rosenberg.
Blood, 2005 Nov 24; 107(6). PMID: 16304057    Free PMC article.
Highly Cited.
Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.
Dirk Homann, Wolfgang Dummer, +4 authors, Matthias G von Herrath.
J Virol, 2005 Dec 15; 80(1). PMID: 16352552    Free PMC article.
Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells.
Elena Gonzalez-Rey, Alejo Chorny, +2 authors, Mario Delgado.
Blood, 2006 Jan 07; 107(9). PMID: 16397128    Free PMC article.
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma.
Zhi-Zhang Yang, Anne J Novak, +2 authors, Stephen M Ansell.
Blood, 2006 Jan 13; 107(9). PMID: 16403912    Free PMC article.
Highly Cited.
Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4(+) CD25(+) T cells of patients with inflammatory bowel disease.
Maho Ikeda, Fuminao Takeshima, +6 authors, Shigeru Kohno.
Dig Dis Sci, 2006 Jan 18; 51(1). PMID: 16416233
Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response.
Alejo Chorny, Elena Gonzalez-Rey, +2 authors, Mario Delgado.
Blood, 2006 Jan 19; 107(9). PMID: 16418327    Free PMC article.
The immune paradox of sarcoidosis and regulatory T cells.
Makoto Miyara, Zahir Amoura, +9 authors, Guy Gorochov.
J Exp Med, 2006 Jan 25; 203(2). PMID: 16432251    Free PMC article.
Highly Cited.
B cell-deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis.
Shiguang Yu, Prasanta K Maiti, +2 authors, Helen Braley-Mullen.
J Exp Med, 2006 Feb 01; 203(2). PMID: 16446379    Free PMC article.
Regulatory T cell-mediated transplantation tolerance.
Ankit Bharat, Ryan Courtney Fields, T Mohanakumar.
Immunol Res, 2006 Feb 08; 33(3). PMID: 16461998
In vivo sites and cellular mechanisms of T reg cell-mediated suppression.
Alexander Y Rudensky, Daniel J Campbell.
J Exp Med, 2006 Mar 15; 203(3). PMID: 16533888    Free PMC article.
Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells.
Alison Taylor, Johan Verhagen, +2 authors, Cezmi A Akdis.
Immunology, 2006 Mar 25; 117(4). PMID: 16556256    Free PMC article.
Highly Cited. Review.
Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells.
Isabel Barao, Alan M Hanash, +6 authors, William J Murphy.
Proc Natl Acad Sci U S A, 2006 Mar 29; 103(14). PMID: 16567639    Free PMC article.
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.
Paul A Antony, Chrystal M Paulos, +9 authors, Nicholas P Restifo.
J Immunol, 2006 Apr 20; 176(9). PMID: 16621991    Free PMC article.
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells.
Haiying Liu, Mousa Komai-Koma, Damo Xu, Foo Y Liew.
Proc Natl Acad Sci U S A, 2006 Apr 25; 103(18). PMID: 16632602    Free PMC article.
Highly Cited.
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.
Kimberly E Beck, Joseph A Blansfield, +12 authors, James C Yang.
J Clin Oncol, 2006 May 20; 24(15). PMID: 16710025    Free PMC article.
Highly Cited.
CD4+ CD25+ regulatory T cells modulate the T-cell and antibody responses in helicobacter-infected BALB/c mice.
Maria Kaparakis, Karen L Laurie, +5 authors, Richard A Strugnell.
Infect Immun, 2006 May 23; 74(6). PMID: 16714584    Free PMC article.
Regulatory T cells: present facts and future hopes.
Christian Becker, Sabine Stoll, +2 authors, Helmut Jonuleit.
Med Microbiol Immunol, 2006 May 23; 195(3). PMID: 16715254
Checkpoint blockade in cancer immunotherapy.
Alan J Korman, Karl S Peggs, James P Allison.
Adv Immunol, 2006 May 30; 90. PMID: 16730267    Free PMC article.
Highly Cited. Review.
Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling.
Alexandra Zanin-Zhorov, Liora Cahalon, +3 authors, Irun R Cohen.
J Clin Invest, 2006 Jun 13; 116(7). PMID: 16767222    Free PMC article.
Highly Cited.
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.
Cecilia Oderup, Lukas Cederbom, +2 authors, Fredrik Ivars.
Immunology, 2006 Jun 15; 118(2). PMID: 16771859    Free PMC article.
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells.
Sergio A Quezada, Karl S Peggs, Michael A Curran, James P Allison.
J Clin Invest, 2006 Jun 17; 116(7). PMID: 16778987    Free PMC article.
Highly Cited.
The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children.
C-O Jonson, M Hedman, +5 authors, ABIS Study Group.
Clin Exp Immunol, 2006 Jun 24; 145(1). PMID: 16792673    Free PMC article.
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.
Ajay V Maker, James C Yang, +11 authors, Steven A Rosenberg.
J Immunother, 2006 Jun 27; 29(4). PMID: 16799341    Free PMC article.
Regulatory T cells in experimental autoimmune disease.
Elisabeth Suri-Payer, Benedikt Fritzsching.
Springer Semin Immunopathol, 2006 Jul 14; 28(1). PMID: 16838180
Self-antigen recognition by TGF beta1-deficient T cells causes their activation and systemic inflammation.
Ramireddy Bommireddy, Leena J Pathak, +7 authors, Thomas Doetschman.
Lab Invest, 2006 Jul 26; 86(10). PMID: 16865088    Free PMC article.
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.
Luca Gattinoni, Anju Ranganathan, +6 authors, Nicholas P Restifo.
Blood, 2006 Aug 03; 108(12). PMID: 16882704    Free PMC article.
Costimulation couture: a designer approach to regulating autoimmunity.
Mohammed Javeed Ansari, Mohamed H Sayegh.
J Clin Invest, 2006 Aug 04; 116(8). PMID: 16886054    Free PMC article.
Anti-CD25 antibody treatment of mice vaccinated and challenged with Borrelia spp. does not exacerbate arthritis but inhibits borreliacidal antibody production.
Dean T Nardelli, Thomas F Warner, Steven M Callister, Ronald F Schell.
Clin Vaccine Immunol, 2006 Aug 09; 13(8). PMID: 16893988    Free PMC article.
Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy.
Kirsty S Nicolson, David C Wraith.
Inflamm Allergy Drug Targets, 2006 Aug 22; 5(3). PMID: 16918477    Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer.
R Houston Thompson, James P Allison, Eugene D Kwon.
Urol Oncol, 2006 Sep 12; 24(5). PMID: 16962497    Free PMC article.
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Simon Read, Rebecca Greenwald, +5 authors, Fiona Powrie.
J Immunol, 2006 Sep 20; 177(7). PMID: 16982872    Free PMC article.
Highly Cited.
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
John J Zaunders, Susanna Ip, +15 authors, Anthony D Kelleher.
J Virol, 2006 Sep 29; 80(20). PMID: 17005693    Free PMC article.
Application of cellular gene therapy for rheumatoid arthritis.
Atsuo Nakajima.
Mod Rheumatol, 2006 Oct 14; 16(5). PMID: 17039306    Free PMC article.
Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease.
Robert Zeiser, Vu H Nguyen, +5 authors, Robert S Negrin.
Blood, 2006 Oct 28; 109(5). PMID: 17068147    Free PMC article.
CD8 blockade promotes the expansion of antigen-specific CD4+ FOXP3+ regulatory T cells in vivo.
Z Wang, J D Davies.
Int Immunopharmacol, 2006 Dec 21; 7(2). PMID: 17178393    Free PMC article.
Suppressor role of rat CD8+CD45RClow T cells in experimental autoimmune uveitis (EAU).
Gencheng Han, Hui Shao, +4 authors, Deming Sun.
J Neuroimmunol, 2007 Jan 02; 183(1-2). PMID: 17196261    Free PMC article.
CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer.
Sarah L Clarke, Gareth J Betts, +8 authors, Andrew J Godkin.
PLoS One, 2007 Jan 06; 1. PMID: 17205133    Free PMC article.
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells.
Francesco Marangoni, Sara Trifari, +11 authors, Loïc Dupré.
J Exp Med, 2007 Feb 14; 204(2). PMID: 17296785    Free PMC article.
Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys.
L E Pereira, F Villinger, +7 authors, A A Ansari.
J Virol, 2007 Feb 23; 81(9). PMID: 17314162    Free PMC article.
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease.
B Afzali, G Lombardi, R I Lechler, G M Lord.
Clin Exp Immunol, 2007 Mar 03; 148(1). PMID: 17328715    Free PMC article.
Highly Cited. Review.
CD4+ CD25+ transforming growth factor-beta-producing T cells are present in the lung in murine tuberculosis and may regulate the host inflammatory response.
C M Mason, E Porretta, P Zhang, S Nelson.
Clin Exp Immunol, 2007 Mar 17; 148(3). PMID: 17362490    Free PMC article.
Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.
Khoon Lin Ling, Sarah E Pratap, +9 authors, Vincenzo Cerundolo.
Cancer Immun, 2007 Mar 29; 7. PMID: 17388261    Free PMC article.
Molecular mechanisms for adaptive tolerance and other T cell anergy models.
Seeyoung Choi, Ronald H Schwartz.
Semin Immunol, 2007 Apr 03; 19(3). PMID: 17400472    Free PMC article.
Role of D-alanylation of Streptococcus gordonii lipoteichoic acid in innate and adaptive immunity.
Karenn G Chan, Matt Mayer, +3 authors, Song F Lee.
Infect Immun, 2007 Apr 11; 75(6). PMID: 17420241    Free PMC article.
An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice.
David C Thomas, Richard J Mellanby, Jenny M Phillips, Anne Cooke.
Immunology, 2007 Apr 18; 121(4). PMID: 17437531    Free PMC article.
Minimally activated CD8 autoreactive T cells specific for IRBP express a high level of Foxp3 and are functionally suppressive.
Yong Peng, Hui Shao, +4 authors, Deming Sun.
Invest Ophthalmol Vis Sci, 2007 Apr 27; 48(5). PMID: 17460277    Free PMC article.
Role of CD28 in fatal autoimmune disorder in scurfy mice.
Nagendra Singh, Phillip R Chandler, +7 authors, Makio Iwashima.
Blood, 2007 Apr 28; 110(4). PMID: 17463170    Free PMC article.
Replenishing Peripheral CD4(+) Regulatory T Cells: A Possible Immune-Intervention Strategy in Type 1 Diabetes?
Charles Sia.
Rev Diabet Stud, 2007 May 10; 3(3). PMID: 17487333    Free PMC article.
Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus.
Bernhard O Boehm, Jeffrey A Bluestone.
Rev Diabet Stud, 2007 May 12; 1(4). PMID: 17491700    Free PMC article.
Stage-specific immune responses in human Necator americanus infection.
S M Geiger, I R Caldas, +6 authors, J M Bethony.
Parasite Immunol, 2007 Jun 20; 29(7). PMID: 17576364    Free PMC article.
Regulatory T cells, transforming growth factor-beta, and immune suppression.
Yisong Y Wan, Richard A Flavell.
Proc Am Thorac Soc, 2007 Jul 04; 4(3). PMID: 17607012    Free PMC article.
Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice.
Ewa Kozlowska, Marzena Biernacka, Marzena Ciechomska, Nadzieja Drela.
Immunology, 2007 Jul 14; 122(3). PMID: 17627771    Free PMC article.
CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion.
Anders E Pedersen, Franca Ronchese.
J Immune Based Ther Vaccines, 2007 Jul 31; 5. PMID: 17662155    Free PMC article.
Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.
Sayuri Yamazaki, Anthony J Bonito, +3 authors, Ralph M Steinman.
Blood, 2007 Aug 19; 110(13). PMID: 17699744    Free PMC article.
Transplantation tolerance: lessons from experimental rodent models.
Cherry I Kingsley, Satish N Nadig, Kathryn J Wood.
Transpl Int, 2007 Aug 23; 20(10). PMID: 17711408    Free PMC article.
Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia.
Frank J Ward, Andrew M Hall, +4 authors, Robert N Barker.
Blood, 2007 Sep 01; 111(2). PMID: 17761830    Free PMC article.
Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection.
Guoping Peng, Shuping Li, +3 authors, Zhi Chen.
Immunology, 2007 Sep 04; 123(1). PMID: 17764450    Free PMC article.
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.
Heather M Gibson, Carrie J Hedgcock, +4 authors, Henry K Wong.
J Immunol, 2007 Sep 06; 179(6). PMID: 17785820    Free PMC article.
Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.
Anthony Joetham, Katsuyuki Takeda, +5 authors, Erwin W Gelfand.
Proc Natl Acad Sci U S A, 2007 Sep 15; 104(38). PMID: 17855564    Free PMC article.
FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load.
Ingrid Karlsson, Benoît Malleret, +4 authors, Bruno Vaslin.
J Virol, 2007 Sep 28; 81(24). PMID: 17898053    Free PMC article.
Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression.
Elizabeth H Field, Katarina Kulhankova, Mohamed E Nasr.
Immunol Res, 2007 Oct 06; 39(1-3). PMID: 17917056
The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand.
Hava Ben-David, Amir Sharabi, +2 authors, Edna Mozes.
Proc Natl Acad Sci U S A, 2007 Oct 25; 104(44). PMID: 17956982    Free PMC article.
Advancements in immune tolerance.
Ping-Ying Pan, Junko Ozao, Zuping Zhou, Shu-Hsia Chen.
Adv Drug Deliv Rev, 2007 Nov 03; 60(2). PMID: 17976856    Free PMC article.
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.
Yisong Y Wan, Richard A Flavell.
Immunol Rev, 2007 Nov 06; 220. PMID: 17979848    Free PMC article.
Highly Cited. Review.
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade.
Stephanie G Downey, Jacob A Klapper, +12 authors, Steven A Rosenberg.
Clin Cancer Res, 2007 Nov 06; 13(22 Pt 1). PMID: 17982122    Free PMC article.
Highly Cited.
T lymphocytes in Sjögren's syndrome: contributors to and regulators of pathophysiology.
Gikas E Katsifis, Niki M Moutsopoulos, Sharon M Wahl.
Clin Rev Allergy Immunol, 2007 Nov 10; 32(3). PMID: 17992592
The role of CTLA-4 in immune regulation.
Johan Verhagen, Catherine A Sabatos, David C Wraith.
Immunol Lett, 2007 Nov 24; 115(1). PMID: 18035425    Free PMC article.
Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.
Ana Izcue, Fiona Powrie.
Immunology, 2007 Dec 25; 123(1). PMID: 18154611    Free PMC article.
T regulatory cells: aid or hindrance in the clearance of disease?
Clint A Coleman, Michaela C Muller-Trutwin, Cristian Apetrei, Ivona Pandrea.
J Cell Mol Med, 2008 Jan 22; 11(6). PMID: 18205702    Free PMC article.
Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.
Zhe Shi, Muhaimin Rifa'i, +3 authors, Haruhiko Suzuki.
Immunology, 2008 Jan 22; 124(1). PMID: 18205792    Free PMC article.
Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease?
Esaki Muthu Shankar, Ramachandran Vignesh, +7 authors, Nagalingeswaran Kumarasamy.
J Inflamm (Lond), 2008 Feb 20; 5. PMID: 18282273    Free PMC article.
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation.
Qizhi Tang, Jeffrey A Bluestone.
Nat Immunol, 2008 Feb 21; 9(3). PMID: 18285775    Free PMC article.
Highly Cited. Review.
Comparative methodologies of regulatory T cell depletion in a murine melanoma model.
Norimasa Matsushita, Shari A Pilon-Thomas, Lisa M Martin, Adam I Riker.
J Immunol Methods, 2008 Feb 26; 333(1-2). PMID: 18295790    Free PMC article.
Regulatory T cells and human disease.
Nathalie Cools, Peter Ponsaerts, Viggo F I Van Tendeloo, Zwi N Berneman.
Clin Dev Immunol, 2008 Mar 05; 2007. PMID: 18317534    Free PMC article.
Immunoregulatory T cells: role and potential as a target in malignancy.
Marc Beyer, Joachim L Schultze.
Curr Oncol Rep, 2008 Apr 02; 10(2). PMID: 18377826
TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells.
Marta Catalfamo, Xuguang Tai, +2 authors, Pierre A Henkart.
Immunology, 2008 Apr 10; 125(1). PMID: 18397268    Free PMC article.
CTLA-4 trafficking and surface expression.
Elke Valk, Christopher E Rudd, Helga Schneider.
Trends Immunol, 2008 May 13; 29(6). PMID: 18468488    Free PMC article.
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.
Brian Kavanagh, Shaun O'Brien, +6 authors, Lawrence Fong.
Blood, 2008 Jun 05; 112(4). PMID: 18523152    Free PMC article.
CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors.
Kavita V Shah, Andy J Chien, Cassian Yee, Randall T Moon.
J Invest Dermatol, 2008 Jun 20; 128(12). PMID: 18563180    Free PMC article.
Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.
William Stohl, Noam Jacob, +6 authors, Michael N Koss.
J Immunol, 2008 Jun 21; 181(1). PMID: 18566449    Free PMC article.
Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells.
Wenwei Tu, Yu-Lung Lau, +6 authors, David B Lewis.
Blood, 2008 Jul 05; 112(6). PMID: 18599794    Free PMC article.
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.
Yasushi Onishi, Zoltan Fehervari, Tomoyuki Yamaguchi, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2008 Jul 19; 105(29). PMID: 18635688    Free PMC article.
Highly Cited.
Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
Yong Zheng, Claire N Manzotti, +4 authors, David M Sansom.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641304    Free PMC article.
CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.
Anita L Tang, John R Teijaro, +5 authors, Donna L Farber.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641318    Free PMC article.
The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.
Thomas Y Wuest, Jami Willette-Brown, Scott K Durum, Arthur A Hurwitz.
J Leukoc Biol, 2008 Jul 26; 84(4). PMID: 18653463    Free PMC article.
The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.
Jakob Michaëlsson, Hugo Marcelo R Barbosa, +9 authors, Esper G Kallas.
BMC Immunol, 2008 Jul 31; 9. PMID: 18664281    Free PMC article.
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Renata Mazzucchelli, Julie A Hixon, +7 authors, Scott K Durum.
Blood, 2008 Jul 31; 112(8). PMID: 18664628    Free PMC article.
Helminth infections and intestinal inflammation.
Li Jian Wang, Yue Cao, Hai Ning Shi.
World J Gastroenterol, 2008 Sep 09; 14(33). PMID: 18777588    Free PMC article.
TGF-beta and regulatory T cell in immunity and autoimmunity.
Yisong Y Wan, Richard A Flavell.
J Clin Immunol, 2008 Sep 17; 28(6). PMID: 18792765    Free PMC article.
Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells.
David C Gondek, Victor Devries, +4 authors, Randolph J Noelle.
J Immunol, 2008 Sep 20; 181(7). PMID: 18802078    Free PMC article.
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood.
Wakae Fujimaki, Nozomu Takahashi, +6 authors, Chikao Morimoto.
Clin Dev Immunol, 2008 Sep 26; 2008. PMID: 18815628    Free PMC article.
Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.
Gisen Kim, Olga Turovskaya, +4 authors, Mitchell Kronenberg.
J Immunol, 2008 Oct 04; 181(8). PMID: 18832683    Free PMC article.
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure.
Flurina Meiler, Judith Zumkehr, +3 authors, Mübeccel Akdis.
J Exp Med, 2008 Nov 13; 205(12). PMID: 19001136    Free PMC article.
Highly Cited.
Involvement of IL-10 in the suppression of antibody production by in vitro immunized peripheral blood mononuclear cells.
Makiko Yamashita, Yoshinori Katakura, +5 authors, Sanetaka Shirahata.
Cytotechnology, 2008 Nov 13; 55(2-3). PMID: 19002996    Free PMC article.
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Xin Yu, Kristin Harden, +9 authors, Jane L Grogan.
Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627
Highly Cited.
Dendritic cells in the thymus contribute to T-regulatory cell induction.
Anna I Proietto, Serani van Dommelen, +9 authors, Li Wu.
Proc Natl Acad Sci U S A, 2008 Dec 17; 105(50). PMID: 19073916    Free PMC article.
Highly Cited.
Retinoic acid in the immune system.
Karina Pino-Lagos, Micah J Benson, Randolph J Noelle.
Ann N Y Acad Sci, 2008 Dec 17; 1143. PMID: 19076350    Free PMC article.
Regulatory T cells in renal disease.
Yuan Min Wang, Min Hu, +6 authors, Stephen I Alexander.
Int J Clin Exp Med, 2008 Dec 17; 1(4). PMID: 19079673    Free PMC article.
Immunoregulatory pathways controlling progression of autoimmunity in NOD mice.
Sylvaine You, Marie-Alexandra Alyanakian, +4 authors, Lucienne Chatenoud.
Ann N Y Acad Sci, 2009 Jan 06; 1150. PMID: 19120317    Free PMC article.
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants.
Marta Barreto, Ricardo C Ferreira, +12 authors, Astrid M Vicente.
BMC Immunol, 2009 Jan 29; 10. PMID: 19173720    Free PMC article.
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.
Ye Zheng, Ashutosh Chaudhry, +7 authors, Alexander Y Rudensky.
Nature, 2009 Feb 03; 458(7236). PMID: 19182775    Free PMC article.
Highly Cited.
Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge.
Jared H Rowe, Tanner M Johanns, +2 authors, Sing Sing Way.
Immunology, 2009 Feb 05; 128(1 Suppl). PMID: 19191906    Free PMC article.
Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival.
Riccardo D'Elia, Jerzy M Behnke, Janette E Bradley, Kathryn J Else.
J Immunol, 2009 Feb 10; 182(4). PMID: 19201888    Free PMC article.
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.
Johan Verhagen, Leona Gabrysová, +4 authors, David C Wraith.
Proc Natl Acad Sci U S A, 2009 Feb 17; 106(9). PMID: 19218450    Free PMC article.
Effects of oral commensal and pathogenic bacteria on human dendritic cells.
T Chino, D M Santer, +5 authors, E A Clark.
Oral Microbiol Immunol, 2009 Feb 26; 24(2). PMID: 19239635    Free PMC article.
Regulatory T cells overturned: the effectors fight back.
Lucy S K Walker.
Immunology, 2009 Mar 13; 126(4). PMID: 19278420    Free PMC article.
Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?
Leigh R Guerin, Jelmer R Prins, Sarah A Robertson.
Hum Reprod Update, 2009 Mar 13; 15(5). PMID: 19279047    Free PMC article.
Systematic Review.
CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.
Mohammad S Alam, Courtney C Kurtz, +6 authors, Peter B Ernst.
J Infect Dis, 2009 Mar 14; 199(4). PMID: 19281303    Free PMC article.
Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma.
Darryl A Oble, Robert Loewe, Ping Yu, Martin C Mihm.
Cancer Immun, 2009 Apr 03; 9. PMID: 19338264    Free PMC article.
CD28 and CTLA-4 coreceptor expression and signal transduction.
Christopher E Rudd, Alison Taylor, Helga Schneider.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426212    Free PMC article.
Highly Cited. Review.
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.
Hélène Bour-Jordan, Jeffrey A Bluestone.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426214    Free PMC article.
CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation.
Dorothy K Sojka, Angela Hughson, Deborah J Fowell.
Eur J Immunol, 2009 May 23; 39(6). PMID: 19462377    Free PMC article.
Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice.
Christophe M Filippi, Elizabeth A Estes, Janine E Oldham, Matthias G von Herrath.
J Clin Invest, 2009 May 30; 119(6). PMID: 19478458    Free PMC article.
Molecular orchestration of differentiation and function of regulatory T cells.
Li-Fan Lu, Alexander Rudensky.
Genes Dev, 2009 Jun 03; 23(11). PMID: 19487568    Free PMC article.
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.
C Coquerelle, G Oldenhove, +6 authors, M Moser.
Gut, 2009 Jun 10; 58(10). PMID: 19505881    Free PMC article.
Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells.
James D Lord, Robert C Hackman, +5 authors, George B McDonald.
Dig Dis Sci, 2009 Jun 10; 55(5). PMID: 19507029    Free PMC article.
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.
Timothy R D J Radstake, Lenny van Bon, +7 authors, Robert Lafyatis.
PLoS One, 2009 Jun 23; 4(6). PMID: 19543397    Free PMC article.
High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.
Andrew G Brandmaier, Wolfgang W Leitner, +3 authors, Christopher E Touloukian.
J Immunother, 2009 Jun 30; 32(7). PMID: 19561540    Free PMC article.
Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity.
Reiner K W Mailer, Kirsten Falk, Olaf Rötzschke.
PLoS One, 2009 Jul 02; 4(7). PMID: 19568423    Free PMC article.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Karl S Peggs, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407    Free PMC article.
Highly Cited.
CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.
Marleen M Welsh, Katie M Applebaum, +3 authors, Heather H Nelson.
Cancer Res, 2009 Jul 23; 69(15). PMID: 19622768    Free PMC article.
CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.
Paul L Bollyky, Ben A Falk, +7 authors, Gerald T Nepom.
J Immunol, 2009 Jul 29; 183(4). PMID: 19635906    Free PMC article.
Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice.
Demetri J Merianos, Eleonor Tiblad, +5 authors, Alan W Flake.
J Clin Invest, 2009 Aug 05; 119(9). PMID: 19652363    Free PMC article.
How do regulatory T cells work?
A Corthay.
Scand J Immunol, 2009 Sep 16; 70(4). PMID: 19751267    Free PMC article.
Highly Cited. Review.
The role of costimulatory molecules in allergic disease and asthma.
Vincent Lombardi, Abinav K Singh, Omid Akbari.
Int Arch Allergy Immunol, 2009 Sep 30; 151(3). PMID: 19786798    Free PMC article.
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.
Andreas Bonertz, Jürgen Weitz, +12 authors, Philipp Beckhove.
J Clin Invest, 2009 Oct 08; 119(11). PMID: 19809157    Free PMC article.
Engineered interleukin-2 antagonists for the inhibition of regulatory T cells.
David V Liu, Lisa M Maier, David A Hafler, K Dane Wittrup.
J Immunother, 2009 Oct 10; 32(9). PMID: 19816193    Free PMC article.
Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells?
Hua-xia Yang, Wen Zhang, +5 authors, Xuan Zhang.
Arthritis Res Ther, 2009 Oct 14; 11(5). PMID: 19821980    Free PMC article.
Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain.
Maria E Moreno-Fernandez, Wildeman Zapata, +2 authors, Claire A Chougnet.
J Virol, 2009 Oct 16; 83(24). PMID: 19828616    Free PMC article.
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.
Louisa E Jeffery, Fiona Burke, +7 authors, David M Sansom.
J Immunol, 2009 Oct 22; 183(9). PMID: 19843932    Free PMC article.
Highly Cited.
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells.
Jacqueline P Law, Dale F Hirschkorn, +3 authors, Marion C Lanteri.
Cytometry A, 2009 Oct 22; 75(12). PMID: 19845018    Free PMC article.
Tregs control the development of symptomatic West Nile virus infection in humans and mice.
Marion C Lanteri, Katie M O'Brien, +17 authors, Philip J Norris.
J Clin Invest, 2009 Oct 27; 119(11). PMID: 19855131    Free PMC article.
Highly Cited.
Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis.
Graham P Wright, Clare A Notley, +5 authors, Hans J Stauss.
Proc Natl Acad Sci U S A, 2009 Nov 04; 106(45). PMID: 19884493    Free PMC article.
Immune tolerance induction by integrating innate and adaptive immune regulators.
Jun Suzuki, Camillo Ricordi, Zhibin Chen.
Cell Transplant, 2009 Nov 19; 19(3). PMID: 19919733    Free PMC article.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
William Humphries, Jun Wei, John H Sampson, Amy B Heimberger.
Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972    Free PMC article.
Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.
Sheng F Cai, Xuefang Cao, +2 authors, Timothy J Ley.
Blood, 2009 Dec 08; 115(9). PMID: 19965675    Free PMC article.
Frequency of Treg cells is reduced in CVID patients with autoimmunity and splenomegaly and is associated with expanded CD21lo B lymphocytes.
Gururaj Arumugakani, Philip M D Wood, Clive R D Carter.
J Clin Immunol, 2009 Dec 10; 30(2). PMID: 19997968
Regulatory T cells exert checks and balances on self tolerance and autoimmunity.
Kajsa Wing, Shimon Sakaguchi.
Nat Immunol, 2009 Dec 18; 11(1). PMID: 20016504
Highly Cited. Review.
Dendritic cell modulation as a new interventional approach for the treatment of asthma.
Vincent Lombardi, Omid Akbari.
Drug News Perspect, 2009 Dec 18; 22(8). PMID: 20016853    Free PMC article.
FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.
Anita Schildknecht, Sabine Brauer, +5 authors, Maries van den Broek.
Proc Natl Acad Sci U S A, 2009 Dec 19; 107(1). PMID: 20018763    Free PMC article.
Reduction of Foxp3+ cells by depletion with the PC61 mAb induces mortality in resistant BALB/c mice infected with Toxoplasma gondii.
Eda Patricia Tenorio, Jonadab Efraín Olguín, +2 authors, Rafael Saavedra.
J Biomed Biotechnol, 2009 Dec 29; 2010. PMID: 20037737    Free PMC article.
Gatekeepers of intestinal inflammation.
Heather A Arnett, Joanne L Viney.
Inflamm Res, 2010 Jan 13; 59(1). PMID: 20066780
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.
Nitya Jain, Hai Nguyen, Cynthia Chambers, Joonsoo Kang.
Proc Natl Acad Sci U S A, 2010 Jan 19; 107(4). PMID: 20080649    Free PMC article.
Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells.
Shuzi Zhang, Hehua Dai, +2 authors, Zhenhua Dai.
PLoS One, 2010 Jan 22; 5(1). PMID: 20090908    Free PMC article.
Regeneration of dendritic cells in aged mice.
Serani L H van Dommelen, Alexandra Rizzitelli, +3 authors, Li Wu.
Cell Mol Immunol, 2010 Feb 02; 7(2). PMID: 20118970    Free PMC article.
Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases.
Franco Pandolfi, Rossella Cianci, +2 authors, Giovanni Cammarota.
Mediators Inflamm, 2010 Feb 20; 2009. PMID: 20169125    Free PMC article.
Regulatory T cells: roles of T cell receptor for their development and function.
Naganari Ohkura, Shimon Sakaguchi.
Semin Immunopathol, 2010 Feb 25; 32(2). PMID: 20179931
Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
Louise A Swainson, Jeff E Mold, Urmila D Bajpai, Joseph M McCune.
J Immunol, 2010 Mar 02; 184(7). PMID: 20190142    Free PMC article.
PSK may suppress CD57(+) T cells to improve survival of advanced gastric cancer patients.
Junji Akagi, Hideo Baba.
Int J Clin Oncol, 2010 Mar 17; 15(2). PMID: 20229169
HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses.
Rachel E Owen, John W Heitman, +7 authors, NIAID Center for HIV/AIDS Vaccine Immunology.
AIDS, 2010 Apr 20; 24(8). PMID: 20400885    Free PMC article.
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.
Jaebok Choi, Julie Ritchey, +5 authors, John F DiPersio.
Blood, 2010 Apr 29; 116(1). PMID: 20424188    Free PMC article.
Highly Cited.
Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot.
Xiaohui Zhou, Julie Wang, +4 authors, Song Guo Zheng.
J Mol Cell Biol, 2010 May 01; 2(3). PMID: 20430855    Free PMC article.
CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model.
Haruei Ogino, Kazuhiko Nakamura, +2 authors, Ryoichi Takayanagi.
Dig Dis Sci, 2010 Jun 04; 56(2). PMID: 20521112
Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells.
Brian G Engelhardt, James E Crowe.
Curr Top Microbiol Immunol, 2010 Jun 22; 341. PMID: 20563712    Free PMC article.
The power and the promise of restimulation-induced cell death in human immune diseases.
Andrew L Snow, Pushpa Pandiyan, +2 authors, Michael J Lenardo.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636809    Free PMC article.
The PD-1 pathway in tolerance and autoimmunity.
Loise M Francisco, Peter T Sage, Arlene H Sharpe.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636820    Free PMC article.
Highly Cited. Review.
Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection.
Ross B Fulton, David K Meyerholz, Steven M Varga.
J Immunol, 2010 Jul 20; 185(4). PMID: 20639494    Free PMC article.
Highly Cited.
Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment.
Paolo A Ascierto, Maria Napolitano, +14 authors, Nicola Mozzillo.
J Transl Med, 2010 Aug 18; 8. PMID: 20712892    Free PMC article.
Anti-inflammatory treatment of uveitis with biologicals: new treatment options that reflect pathogenetic knowledge of the disease.
Arnd Heiligenhaus, Stephan Thurau, +2 authors, Gerhild Wildner.
Graefes Arch Clin Exp Ophthalmol, 2010 Aug 26; 248(11). PMID: 20737162
The landscape of human genes involved in the immune response to parasitic worms.
Matteo Fumagalli, Uberto Pozzoli, +4 authors, Manuela Sironi.
BMC Evol Biol, 2010 Sep 03; 10. PMID: 20807397    Free PMC article.
Induction of T cell anergy: integration of environmental cues and infectious tolerance.
Pascal Chappert, Ronald H Schwartz.
Curr Opin Immunol, 2010 Sep 28; 22(5). PMID: 20869863    Free PMC article.
Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo.
N M Rogers, S Kireta, P T H Coates.
Clin Exp Immunol, 2010 Nov 13; 162(3). PMID: 21070208    Free PMC article.
Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells.
Esaki Muthu Shankar, Karlhans Fru Che, +2 authors, Marie Larsson.
Mol Med, 2010 Nov 26; 17(3-4). PMID: 21103670    Free PMC article.
The role of natural regulatory T cells in infection.
Ana M Sanchez, Yiping Yang.
Immunol Res, 2010 Dec 01; 49(1-3). PMID: 21116872    Free PMC article.
Hepatitis B e-antigen persistency is associated with the properties of HBV-specific CD8 T cells in CHB patients.
Guoping Peng, Benyan Luo, +4 authors, Zhi Chen.
J Clin Immunol, 2010 Dec 02; 31(2). PMID: 21120686
CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with -318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients.
Shaoqiong Duan, Guoyu Zhang, +11 authors, Fanfan Xing.
Mol Biol Rep, 2010 Dec 17; 38(8). PMID: 21161390
Genetic susceptibility to autoimmune liver disease.
Jochen Mattner.
World J Hepatol, 2011 Feb 11; 3(1). PMID: 21307981    Free PMC article.
Lung T-cell subset composition at the time of surgical resection is a prognostic indicator in non-small cell lung cancer.
T A Zikos, A D Donnenberg, +2 authors, V S Donnenberg.
Cancer Immunol Immunother, 2011 Mar 05; 60(6). PMID: 21373990    Free PMC article.
Regulatory T cells in HIV immunotherapy.
Bernard Jc Macatangay, Charles R Rinaldo.
HIV Ther, 2011 Apr 05; 4(6). PMID: 21461400    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Jeffrey A Bluestone.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898    Free PMC article.
Highly Cited. Review.
Regulatory T cells and Foxp3.
Alexander Y Rudensky.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488902    Free PMC article.
Highly Cited. Review.
Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.
Masahito Kamanaka, Samuel Huber, +8 authors, Richard A Flavell.
J Exp Med, 2011 Apr 27; 208(5). PMID: 21518800    Free PMC article.
The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function.
Kay D Gerold, Peilin Zheng, +3 authors, Stephan Kissler.
Diabetes, 2011 May 24; 60(7). PMID: 21602513    Free PMC article.
Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).
Derek V Chan, Ally-Khan Somani, +7 authors, Thomas S McCormick.
BMC Biochem, 2011 May 28; 12. PMID: 21615933    Free PMC article.
Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice.
Eva Gückel, Silke Frey, +3 authors, Reinhard E Voll.
PLoS One, 2011 Jun 01; 6(5). PMID: 21625598    Free PMC article.
Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.
Xin Chen, Joost J Oppenheim.
Int Immunopharmacol, 2011 Jun 04; 11(10). PMID: 21635972    Free PMC article.
Obstructive jaundice expands intrahepatic regulatory T cells, which impair liver T lymphocyte function but modulate liver cholestasis and fibrosis.
Steven C Katz, Kristin Ryan, +9 authors, Ronald P Dematteo.
J Immunol, 2011 Jun 24; 187(3). PMID: 21697460    Free PMC article.
Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients.
Laure Vallotton, Karine Hadaya, +7 authors, Manuel Pascual.
Clin J Am Soc Nephrol, 2011 Jul 16; 6(8). PMID: 21757642    Free PMC article.
Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling.
Felipe Saldanha-Araujo, Rodrigo Haddad, +8 authors, Rodrigo A Panepucci.
J Cell Mol Med, 2011 Jul 23; 16(6). PMID: 21777379    Free PMC article.
Regulatory T cell: a protection for tumour cells.
Yi Wang, Yushui Ma, +4 authors, Xizhong Shen.
J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966    Free PMC article.
Influence of short-term glucocorticoid therapy on regulatory T cells in vivo.
Silviu Sbiera, Thomas Dexneit, +10 authors, Martin Fassnacht.
PLoS One, 2011 Sep 14; 6(9). PMID: 21912688    Free PMC article.
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.
Hardis Rabe, Anna-Carin Lundell, +3 authors, Anna Rudin.
J Leukoc Biol, 2011 Sep 22; 90(6). PMID: 21934066    Free PMC article.
Induction of contact-dependent CD8(+) regulatory T cells through stimulation with staphylococcal and streptococcal superantigens.
Amanda L Taylor, Elizabeth L A Cross, Martin J Llewelyn.
Immunology, 2011 Nov 03; 135(2). PMID: 22043981    Free PMC article.
Identification of a unique double-negative regulatory T-cell population.
Byung O Lee, Joyce E Jones, +5 authors, David R Milich.
Immunology, 2011 Nov 03; 134(4). PMID: 22044159    Free PMC article.
Dysregulated expression of both the costimulatory CD28 and inhibitory CTLA-4 molecules in PB T cells of advanced cervical cancer patients suggests systemic immunosuppression related to disease progression.
Agata Kosmaczewska, Dorota Bocko, +5 authors, Irena Frydecka.
Pathol Oncol Res, 2011 Nov 19; 18(2). PMID: 22094905    Free PMC article.
T regulatory cells in B-cell malignancy - tumour support or kiss of death?
Camilla A Lindqvist, Angelica S I Loskog.
Immunology, 2011 Nov 25; 135(4). PMID: 22112044    Free PMC article.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Lucy S K Walker, David M Sansom.
Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087
Highly Cited.
Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity.
Sue M Liu, Andrew P R Sutherland, +7 authors, Vijay K Kuchroo.
J Immunol, 2011 Nov 30; 188(1). PMID: 22124121    Free PMC article.
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.
Jeffrey Pido-Lopez, William W Kwok, +2 authors, Neil A Williams.
PLoS Pathog, 2011 Dec 07; 7(12). PMID: 22144893    Free PMC article.
Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease.
Rudi Alberts, Hairong Chen, +6 authors, Klaus Schughart.
BMC Genomics, 2011 Dec 21; 12. PMID: 22182475    Free PMC article.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Oana Draghiciu, Hans W Nijman, Toos Daemen.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971    Free PMC article.
Regulatory T cells: mechanisms of differentiation and function.
Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781    Free PMC article.
Highly Cited. Review.
Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
Yong Chen, Shudan Shen, +2 authors, Xiao-Ping Zhong.
J Immunol, 2012 Jan 11; 188(4). PMID: 22231701    Free PMC article.
In vivo expansion of naïve CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration.
Marc Beyer, Beatrix Schumak, +7 authors, Joachim L Schultze.
PLoS One, 2012 Jan 26; 7(1). PMID: 22276195    Free PMC article.
A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis.
Zulkarnain Md Idris, Maria Yazdanbakhsh, +3 authors, Rahmah Noordin.
Genet Test Mol Biomarkers, 2012 Feb 01; 16(6). PMID: 22288822    Free PMC article.
Immunotherapy for the treatment of glioblastoma.
Alissa A Thomas, Marc S Ernstoff, Camilo E Fadul.
Cancer J, 2012 Feb 01; 18(1). PMID: 22290259    Free PMC article.
MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function.
Hussein Fayyad-Kazan, Redouane Rouas, +11 authors, Philippe Martiat.
J Biol Chem, 2012 Feb 02; 287(13). PMID: 22294691    Free PMC article.
Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.
K Singh, N Kozyr, +4 authors, L S Kean.
Am J Transplant, 2012 Feb 04; 12(6). PMID: 22300641    Free PMC article.
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Peng Gu, Julia Fang Gao, +3 authors, Li Zhang.
Cell Mol Immunol, 2012 Feb 07; 9(2). PMID: 22307040    Free PMC article.
Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium.
Kirsten E Lyke, Abdoulaye Dabo, +6 authors, Marcelo B Sztein.
PLoS One, 2012 Feb 22; 7(2). PMID: 22348117    Free PMC article.
Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome.
Hongen Yin, Cuong Q Nguyen, +3 authors, John A Chiorini.
Arthritis Res Ther, 2012 Mar 01; 14(1). PMID: 22369699    Free PMC article.
Unmasking the immune recognition of prostate cancer with CTLA4 blockade.
Serena S Kwek, Edward Cha, Lawrence Fong.
Nat Rev Cancer, 2012 Mar 02; 12(4). PMID: 22378189    Free PMC article.
Correlation between the cord vitamin D levels and regulatory T cells in newborn infants.
Ayşegül Güven, Ayşe Ecevit, +3 authors, Namık Ozbek.
Eur J Pediatr, 2012 Mar 03; 171(8). PMID: 22383070
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Xuguang Tai, François Van Laethem, +9 authors, Alfred Singer.
Blood, 2012 Mar 10; 119(22). PMID: 22403258    Free PMC article.
Highly Cited.
Regulation generation: the suppressive functions of human regulatory T cells.
Wendy A Goodman, Kevin D Cooper, Thomas S McCormick.
Crit Rev Immunol, 2012 Mar 21; 32(1). PMID: 22428855    Free PMC article.
Management of cutaneous T cell lymphoma: new and emerging targets and treatment options.
Janet Y Li, Steven Horwitz, +3 authors, Christiane Querfeld.
Cancer Manag Res, 2012 Mar 30; 4. PMID: 22457602    Free PMC article.
Regulatory T cells in human ovarian cancer.
Dong-Jun Peng, Rebecca Liu, Weiping Zou.
J Oncol, 2012 Apr 07; 2012. PMID: 22481922    Free PMC article.
Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immunosuppressive cells.
Yushe Dang, Wolfgang M Wagner, +4 authors, Mary L Disis.
Clin Cancer Res, 2012 Apr 19; 18(11). PMID: 22510348    Free PMC article.
Generation of induced regulatory T cells from primary human naïve and memory T cells.
Gavin I Ellis, Mary Catherine Reneer, +2 authors, Francesc Martí.
J Vis Exp, 2012 Apr 25; (62). PMID: 22525890    Free PMC article.
The molecular mechanisms of regulatory T cell immunosuppression.
Pushpa Pandiyan, Lixin Zheng, Michael J Lenardo.
Front Immunol, 2011 Jan 01; 2. PMID: 22566849    Free PMC article.
The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells.
Silvia Gregori, Kevin S Goudy, Maria Grazia Roncarolo.
Front Immunol, 2012 May 09; 3. PMID: 22566914    Free PMC article.
The role of coinhibitory signaling pathways in transplantation and tolerance.
Martina M McGrath, Nader Najafian.
Front Immunol, 2012 May 09; 3. PMID: 22566929    Free PMC article.
Molecular mechanisms of treg-mediated T cell suppression.
Angelika Schmidt, Nina Oberle, Peter H Krammer.
Front Immunol, 2012 May 09; 3. PMID: 22566933    Free PMC article.
Highly Cited.
Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities.
Florencia Paula Madorsky-Rowdo, María Laura Lacreu, José Mordoh.
Front Immunol, 2012 May 09; 3. PMID: 22566975    Free PMC article.
On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation.
Anja U Engela, Carla C Baan, +2 authors, Martin J Hoogduijn.
Front Immunol, 2012 May 26; 3. PMID: 22629256    Free PMC article.
Boosting regulatory T cell function by CD4 stimulation enters the clinic.
Christian Becker, Tobias Bopp, Helmut Jonuleit.
Front Immunol, 2012 Jun 22; 3. PMID: 22719741    Free PMC article.
Reduction of circulating regulatory T cells by intravenous high-dose interferon alfa-2b treatment in melanoma patients.
Nicola Mozzillo, Paolo Ascierto.
Clin Exp Metastasis, 2012 Jul 04; 29(7). PMID: 22752507
Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
Chun Jing Wang, Rupert Kenefeck, +6 authors, Lucy S K Walker.
J Immunol, 2012 Jul 04; 189(3). PMID: 22753931    Free PMC article.
Synthesized OVA323-339MAP octamers mitigate OVA-induced airway inflammation by regulating Foxp3 T regulatory cells.
Wen Su, Wenwei Zhong, Yanjie Zhang, Zhenwei Xia.
BMC Immunol, 2012 Jul 10; 13. PMID: 22769043    Free PMC article.
Immunoregulatory molecules are master regulators of inflammation during the immune response.
Hortensia de la Fuente, Danay Cibrián, Francisco Sánchez-Madrid.
FEBS Lett, 2012 Jul 24; 586(18). PMID: 22819828    Free PMC article.
Autologous regulatory T cells for the treatment of type 1 diabetes.
James A Thompson, Daniel Perry, Todd M Brusko.
Curr Diab Rep, 2012 Jul 31; 12(5). PMID: 22843491
Ipilimumab pharmacotherapy in patients with metastatic melanoma.
Joanne M Jeter, Lee D Cranmer, Evan M Hersh.
Clin Med Insights Oncol, 2012 Aug 21; 6. PMID: 22904648    Free PMC article.
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.
Jonathan M Han, Scott J Patterson, Megan K Levings.
Front Immunol, 2012 Aug 21; 3. PMID: 22905034    Free PMC article.
CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
M J Barnes, T Griseri, +3 authors, A Izcue.
Mucosal Immunol, 2012 Aug 23; 6(2). PMID: 22910217    Free PMC article.
Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications.
Luis de la Cruz-Merino, Marylène Lejeune, +6 authors, Tomás Álvaro.
Clin Dev Immunol, 2012 Aug 29; 2012. PMID: 22927872    Free PMC article.
Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for Sézary syndrome.
Heather M Gibson, Anjali Mishra, +3 authors, Henry K Wong.
J Invest Dermatol, 2012 Sep 07; 133(1). PMID: 22951729    Free PMC article.
Treg cells, life history, and diversity.
Christophe Benoist, Diane Mathis.
Cold Spring Harb Perspect Biol, 2012 Sep 07; 4(9). PMID: 22952391    Free PMC article.
Regulation of cytotoxic T lymphocyte antigen 4 by cyclic AMP.
Jinghong Li, Ko-Wei Lin, +4 authors, Patricia W Finn.
Am J Respir Cell Mol Biol, 2012 Oct 02; 48(1). PMID: 23024062    Free PMC article.
A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression.
Rita Simone, Claudya Tenca, +5 authors, Daniele Saverino.
PLoS One, 2012 Oct 11; 7(9). PMID: 23049754    Free PMC article.
The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells.
Andrea Balogh, Eszter Persa, +4 authors, Katalin Lumniczky.
Inflamm Res, 2012 Oct 20; 62(2). PMID: 23080082
Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low/-) T cells in patients with myasthenia gravis.
Muthusamy Thiruppathi, Julie Rowin, +3 authors, Matthew N Meriggioli.
Clin Immunol, 2012 Nov 01; 145(3). PMID: 23110942    Free PMC article.
Regulatory T cell induction, migration, and function in transplantation.
Bryna E Burrell, Yumi Nakayama, +2 authors, Jonathan S Bromberg.
J Immunol, 2012 Nov 06; 189(10). PMID: 23125426    Free PMC article.
The role of different subsets of regulatory T cells in immunopathogenesis of rheumatoid arthritis.
Maryam Gol-Ara, Farhad Jadidi-Niaragh, +2 authors, Abbas Mirshafiey.
Arthritis, 2012 Nov 08; 2012. PMID: 23133752    Free PMC article.
Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.
Kunihiro Ichinose, Zheng Zhang, +6 authors, George C Tsokos.
Arthritis Rheum, 2012 Dec 04; 65(3). PMID: 23203389    Free PMC article.
Immune tolerance and transplantation.
Onder Alpdogan, Marcel R M van den Brink.
Semin Oncol, 2012 Dec 05; 39(6). PMID: 23206840    Free PMC article.
The role of B7 family molecules in hematologic malignancy.
Paul Greaves, John G Gribben.
Blood, 2012 Dec 12; 121(5). PMID: 23223433    Free PMC article.
The molecular mechanisms of regulatory T cell immunosuppression.
Kendall A Smith.
Front Immunol, 2012 Dec 19; 3. PMID: 23248628    Free PMC article.
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Johan Verhagen, Raphaël Genolet, +5 authors, David C Wraith.
Proc Natl Acad Sci U S A, 2012 Dec 26; 110(3). PMID: 23267099    Free PMC article.
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?
V Kumar.
Purinergic Signal, 2012 Dec 29; 9(2). PMID: 23271562    Free PMC article.
In utero transplanted human hepatocytes allow postnatal engraftment of human hepatocytes in pigs.
James E Fisher, Joseph B Lillegard, +3 authors, Scott L Nyberg.
Liver Transpl, 2013 Jan 03; 19(3). PMID: 23280879    Free PMC article.
Transient depletion of CD4+ CD25+ regulatory T cells results in multiple autoimmune diseases in wild-type and B-cell-deficient NOD mice.
Jason S Ellis, Xiaoxiao Wan, Helen Braley-Mullen.
Immunology, 2013 Jan 09; 139(2). PMID: 23293979    Free PMC article.
HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells.
Julian Wachstein, Sabine Tischer, +5 authors, Britta Eiz-Vesper.
PLoS One, 2013 Jan 10; 7(12). PMID: 23300563    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
Impact of microbes on autoimmune diseases.
Claudia Danzer, Jochen Mattner.
Arch Immunol Ther Exp (Warsz), 2013 Feb 19; 61(3). PMID: 23417246    Free PMC article.
Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.
Emilie Dugast, Endre Kiss-Toth, +9 authors, Joanna Ashton-Chess.
J Biol Chem, 2013 Feb 19; 288(14). PMID: 23417677    Free PMC article.
Functional complexity of the Leishmania granuloma and the potential of in silico modeling.
John W J Moore, Daniel Moyo, +3 authors, Paul M Kaye.
Front Immunol, 2013 Feb 21; 4. PMID: 23423646    Free PMC article.
Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease.
Trevor D Burt.
Am J Reprod Immunol, 2013 Feb 26; 69(4). PMID: 23432802    Free PMC article.
Allergic conjunctivitis renders CD4(+) T cells resistant to t regulatory cells and exacerbates corneal allograft rejection.
N J Reyes, P W Chen, J Y Niederkorn.
Am J Transplant, 2013 Mar 16; 13(5). PMID: 23489547    Free PMC article.
Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy.
Isabela Pedroza-Pacheco, Alejandro Madrigal, Aurore Saudemont.
Cell Mol Immunol, 2013 Mar 26; 10(3). PMID: 23524654    Free PMC article.
Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes.
M Pihl, L Akerman, +5 authors, R Casas.
Clin Exp Immunol, 2013 Apr 23; 172(3). PMID: 23600827    Free PMC article.
Indoleamine 2,3 dioxygenase contributes to transferable tolerance in rat red blood cell inducible model of experimental autoimmune haemolytic anaemia.
L N Dahal, L S Hall, R N Barker, F J Ward.
Clin Exp Immunol, 2013 Apr 24; 173(1). PMID: 23607691    Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
Blockade of programmed death-1 in young (New Zealand Black x New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease.
Maida Wong, Antonio La Cava, Bevra H Hahn.
J Immunol, 2013 May 03; 190(11). PMID: 23636058    Free PMC article.
Monitoring regulatory immune responses in tumor immunotherapy clinical trials.
Brian M Olson, Douglas G McNeel.
Front Oncol, 2013 May 09; 3. PMID: 23653893    Free PMC article.
Nitric oxide-induced regulatory T cells inhibit Th17 but not Th1 cell differentiation and function.
Wanda Niedbala, Anne-Gaelle Besnard, +7 authors, Foo Y Liew.
J Immunol, 2013 May 31; 191(1). PMID: 23720815    Free PMC article.
Analysis of circulating regulatory T cells (CD4+CD25+CD127-) after cryosurgery in prostate cancer.
Tong-Guo Si, Jun-Ping Wang, Zhi Guo.
Asian J Androl, 2013 Jun 04; 15(4). PMID: 23728588    Free PMC article.
New tools to expand regulatory T cells from HIV-1-infected individuals.
Mathieu Angin, Melanie King, Marylyn Martina Addo.
J Vis Exp, 2013 Jun 12; (75). PMID: 23748671    Free PMC article.
An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy.
Khairunadwa Jemon, Vivienne Young, +5 authors, Merilyn Hibma.
PLoS One, 2013 Jun 27; 8(6). PMID: 23799135    Free PMC article.
Treatment of graft-versus-host disease with naturally occurring T regulatory cells.
Piotr Trzonkowski, Anna Dukat-Mazurek, +6 authors, Andrzej Hellmann.
BioDrugs, 2013 Jul 03; 27(6). PMID: 23813436    Free PMC article.
Regulatory T cells in the immunodiagnosis and outcome of kidney allograft rejection.
O Franzese, A Mascali, +3 authors, N Di Daniele.
Clin Dev Immunol, 2013 Jul 12; 2013. PMID: 23843861    Free PMC article.
Treg and CTLA-4: two intertwining pathways to immune tolerance.
Lucy S K Walker.
J Autoimmun, 2013 Jul 16; 45. PMID: 23849743    Free PMC article.
Highly Cited. Review.
Regulatory T cells and regulation of allergic airway disease.
Helen Martin, Christian Taube.
Am J Clin Exp Immunol, 2012 Jan 01; 1(2). PMID: 23885322    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Do Natural T Regulatory Cells become Activated to Antigen Specific T Regulatory Cells in Transplantation and in Autoimmunity?
Bruce M Hall, Giang T Tran, +4 authors, Suzanne J Hodgkinson.
Front Immunol, 2013 Aug 13; 4. PMID: 23935597    Free PMC article.
T cell Receptor Signal Transduction in T lymphocytes.
Balachandra K Gorentla, Xiao-Ping Zhong.
J Clin Cell Immunol, 2013 Aug 16; 2012(Suppl 12). PMID: 23946894    Free PMC article.
ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection.
Qiang Wu, Gail J Gardiner, +11 authors, Rebecca A Shilling.
PLoS One, 2013 Aug 24; 8(8). PMID: 23967339    Free PMC article.
PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.
Pin Zhang, Takashi Maruyama, +4 authors, Wanjun Chen.
PLoS One, 2013 Aug 27; 8(8). PMID: 23977081    Free PMC article.
Regulatory T cell in stroke: a new paradigm for immune regulation.
Sheng Chen, Haijian Wu, +3 authors, Jiping Tang.
Clin Dev Immunol, 2013 Aug 29; 2013. PMID: 23983771    Free PMC article.
Regulatory T cells and Atherosclerosis.
Jahaira Lopez Pastrana, Xiaojin Sha, +5 authors, Xiao-Feng Yang.
J Clin Exp Cardiolog, 2013 Sep 03; 2012(Suppl 12). PMID: 23997979    Free PMC article.
UXT is a novel regulatory factor of regulatory T cells associated with Foxp3.
Weina Li, Lili Wang, +11 authors, Yingqi Zhang.
Eur J Immunol, 2013 Oct 19; 44(2). PMID: 24136450    Free PMC article.
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Jeffrey S Weber, Ragini Reiney Kudchadkar, +11 authors, Y Ann Chen.
J Clin Oncol, 2013 Oct 23; 31(34). PMID: 24145345    Free PMC article.
Highly Cited.
Non-antigenic and antigenic interventions in type 1 diabetes.
Anna K E Rydén, Johnna D Wesley, Ken T Coppieters, Matthias G Von Herrath.
Hum Vaccin Immunother, 2013 Oct 30; 10(4). PMID: 24165565    Free PMC article.
Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation.
D V Chan, H M Gibson, +4 authors, H K Wong.
Genes Immun, 2013 Nov 01; 15(1). PMID: 24173147    Free PMC article.
Regulatory T cells in colorectal cancer: from biology to prognostic relevance.
Dimitrios Mougiakakos.
Cancers (Basel), 2011 Jan 01; 3(2). PMID: 24212779    Free PMC article.
Substantially modified ratios of effector to regulatory T cells during chemotherapy in ovarian cancer patients return to pre-treatment levels at completion: implications for immunotherapy.
Anthony Park, Chindu Govindaraj, +4 authors, Magdalena Plebanski.
Cancers (Basel), 2012 Jan 01; 4(2). PMID: 24213326    Free PMC article.
ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner.
Jian Zheng, Ping-Lung Chan, +6 authors, Wenwei Tu.
PLoS One, 2013 Dec 07; 8(12). PMID: 24312642    Free PMC article.
Peripheral blood regulatory T cells in patients with diffuse systemic sclerosis (SSc) before and after autologous hematopoietic SCT: a pilot study.
J Baraut, E I Grigore, +5 authors, L Michel.
Bone Marrow Transplant, 2013 Dec 24; 49(3). PMID: 24362364
Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells.
Nahzli Dilek, Nicolas Poirier, +7 authors, Bernard Vanhove.
PLoS One, 2014 Jan 01; 8(12). PMID: 24376655    Free PMC article.
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.
Mathieu Angin, Paul L Klarenbeek, +10 authors, Marylyn M Addo.
PLoS One, 2014 Feb 06; 9(2). PMID: 24498287    Free PMC article.
Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer?
Julie R Brahmer.
Semin Oncol, 2014 Feb 26; 41(1). PMID: 24565586    Free PMC article.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander".
Lucia Gelao, Carmen Criscitiello, +2 authors, Giuseppe Curigliano.
Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636    Free PMC article.
Liver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice.
Joseph S Dolina, Thomas J Braciale, Young S Hahn.
Hepatology, 2014 Mar 29; 59(4). PMID: 24677194    Free PMC article.
Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis.
Hardis Rabe, Inger Nordström, +2 authors, Anna Rudin.
Immunology, 2014 Apr 09; 141(3). PMID: 24708420    Free PMC article.
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.
Kesley Attridge, Lucy S K Walker.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712457    Free PMC article.
Immunotherapeutic strategies in autoimmune uveitis.
Pedro Henrique Papotto, Eliana Blini Marengo, +2 authors, Luiz Vicente Rizzo.
Autoimmun Rev, 2014 May 17; 13(9). PMID: 24833504    Free PMC article.
Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity.
Fang-Hsuean Liao, Jr-Wen Shui, +5 authors, Ching-Yu Huang.
Cell Biosci, 2014 Jun 07; 4. PMID: 24904742    Free PMC article.
Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.
Laura Esposito, Kara M D Hunter, +12 authors, Linda S Wicker.
J Immunol, 2014 Jun 15; 193(2). PMID: 24928993    Free PMC article.
Humanized mice as a model for aberrant responses in human T cell immunotherapy.
Nalini K Vudattu, Frank Waldron-Lynch, +6 authors, Kevan C Herold.
J Immunol, 2014 Jun 20; 193(2). PMID: 24943216    Free PMC article.
TREG-cell therapies for autoimmune rheumatic diseases.
Makoto Miyara, Yoshinaga Ito, Shimon Sakaguchi.
Nat Rev Rheumatol, 2014 Jul 02; 10(9). PMID: 24980140
Highly Cited. Review.
Vaccine-based immunotherapy for glioblastoma.
Alissa A Thomas, Jan L Fisher, Marc S Ernstoff, Camilo E Fadul.
CNS Oncol, 2014 Jul 24; 2(4). PMID: 25054578    Free PMC article.
Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.
Daniel S Shin, Ayana Jordan, +5 authors, Fernando Macian.
EMBO Rep, 2014 Jul 31; 15(9). PMID: 25074018    Free PMC article.
Alteration of regulatory T cells in type 1 diabetes mellitus: a comprehensive review.
Tingting Tan, Yufei Xiang, Christopher Chang, Zhiguang Zhou.
Clin Rev Allergy Immunol, 2014 Aug 05; 47(2). PMID: 25086642
Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy.
Shirin Karimi, Subhasis Chattopadhyay, Nitya G Chakraborty.
Immunology, 2014 Sep 23; 144(2). PMID: 25243729    Free PMC article.
Tolerance in organ transplantation: from conventional immunosuppression to extracellular vesicles.
Marta Monguió-Tortajada, Ricardo Lauzurica-Valdemoros, Francesc E Borràs.
Front Immunol, 2014 Oct 04; 5. PMID: 25278936    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Desirée Schubert, Claudia Bode, +37 authors, Bodo Grimbacher.
Nat Med, 2014 Oct 21; 20(12). PMID: 25329329    Free PMC article.
Highly Cited.
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.
Sebastian Zeissig, Britt-Sabina Petersen, +11 authors, Richard S Blumberg.
Gut, 2014 Nov 05; 64(12). PMID: 25367873    Free PMC article.
Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.
S M Krummey, M L Ford.
Am J Transplant, 2014 Nov 13; 14(12). PMID: 25387592    Free PMC article.
Ctla-4 gene polymorphism in +49 a/g position: a case control study on patients with oral lichen planus.
Jannan Ghapanchi, Mohammad Reza Haghshenas, +3 authors, Fereshteh Kamali.
J Int Oral Health, 2014 Nov 15; 6(5). PMID: 25395787    Free PMC article.
Attrition of T-cell functions and simultaneous upregulation of inhibitory markers correspond with the waning of BCG-induced protection against tuberculosis in mice.
Subhadra Nandakumar, Sunil Kannanganat, +2 authors, Suraj B Sable.
PLoS One, 2014 Nov 25; 9(11). PMID: 25419982    Free PMC article.
Potential treatment of inflammatory bowel disease: a review of helminths therapy.
Niloofar Taghipour, Hamid Asadzadeh Aghdaei, +3 authors, Mohammad Rostami-Nejad.
Gastroenterol Hepatol Bed Bench, 2014 Dec 02; 7(1). PMID: 25436093    Free PMC article.
Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Linh T Nguyen, Pamela S Ohashi.
Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622
Highly Cited. Review.
Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.
Helga Schneider, Christopher E Rudd.
Front Immunol, 2014 Dec 30; 5. PMID: 25538704    Free PMC article.
Confusing signals: recent progress in CTLA-4 biology.
Lucy S K Walker, David M Sansom.
Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039    Free PMC article.
Highly Cited. Review.
Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma.
Weiqing Jing, Jill A Gershan, +4 authors, Bryon D Johnson.
J Immunother Cancer, 2015 Jan 24; 3(1). PMID: 25614821    Free PMC article.
Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.
Melanie P Matheu, Shivashankar Othy, +7 authors, Michael D Cahalan.
Nat Commun, 2015 Feb 06; 6. PMID: 25653051    Free PMC article.
The role of checkpoints in the treatment of GBM.
Jennifer E Kim, Michael Lim.
J Neurooncol, 2015 Mar 10; 123(3). PMID: 25749875    Free PMC article.
Interleukin-2 treatment reverses effects of cAMP-responsive element modulator α-over-expressing T cells in autoimmune-prone mice.
K Ohl, A Wiener, +2 authors, K Tenbrock.
Clin Exp Immunol, 2015 Mar 31; 181(1). PMID: 25817470    Free PMC article.
Immunotherapy in Cancer: A Combat between Tumors and the Immune System; You Win Some, You Lose Some.
Florencia Paula Madorsky Rowdo, Antonela Baron, Mariela Urrutia, José Mordoh.
Front Immunol, 2015 Apr 11; 6. PMID: 25859247    Free PMC article.
Human and Mouse CD8(+)CD25(+)FOXP3(+) Regulatory T Cells at Steady State and during Interleukin-2 Therapy.
Guillaume Churlaud, Fabien Pitoiset, +4 authors, David Klatzmann.
Front Immunol, 2015 May 01; 6. PMID: 25926835    Free PMC article.
Highly Cited.
Regulatory T cells turn pathogenic.
Jitao Guo, Xuyu Zhou.
Cell Mol Immunol, 2015 May 06; 12(5). PMID: 25942597    Free PMC article.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Combination of Id2 Knockdown Whole Tumor Cells and Checkpoint Blockade: A Potent Vaccine Strategy in a Mouse Neuroblastoma Model.
Lina Chakrabarti, Clifford Morgan, Anthony D Sandler.
PLoS One, 2015 Jun 17; 10(6). PMID: 26079374    Free PMC article.
The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression.
Alfred P See, Jonathon J Parker, Allen Waziri.
J Neurooncol, 2015 Jul 01; 123(3). PMID: 26123363
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.
Louisa E Jeffery, Omar S Qureshi, +6 authors, David M Sansom.
PLoS One, 2015 Jul 03; 10(7). PMID: 26134669    Free PMC article.
CTLA-4 as a genetic determinant in autoimmune Addison's disease.
A S B Wolff, A L Mitchell, +10 authors, E S Husebye.
Genes Immun, 2015 Jul 24; 16(6). PMID: 26204230    Free PMC article.
CD4+VEGFR1(HIGH) T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice.
Jin-Young Shin, Il-Hee Yoon, +8 authors, Chung-Gyu Park.
Cell Mol Immunol, 2015 Jul 28; 12(5). PMID: 26211666    Free PMC article.
Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites.
Powell Perng, Michael Lim.
Front Oncol, 2015 Jul 29; 5. PMID: 26217588    Free PMC article.
Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors.
Francesca De Felice, Claudia Marchetti, +4 authors, Pierluigi Benedetti Panici.
J Immunol Res, 2015 Aug 04; 2015. PMID: 26236750    Free PMC article.
Process of hepatic metastasis from pancreatic cancer: biology with clinical significance.
Haojun Shi, Ji Li, Deliang Fu.
J Cancer Res Clin Oncol, 2015 Aug 08; 142(6). PMID: 26250876
Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension.
Yoshiharu Sada, Yoshihiro Dohi, +3 authors, Yasuki Kihara.
Heart Vessels, 2015 Sep 01; 31(8). PMID: 26319442
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade.
Elizabeth Buchbinder, F Stephen Hodi.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034    Free PMC article.
Immunosuppression associated with chronic inflammation in the tumor microenvironment.
Dingzhi Wang, Raymond N DuBois.
Carcinogenesis, 2015 Sep 12; 36(10). PMID: 26354776    Free PMC article.
Highly Cited. Review.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M Paterson, Scott B Lovitch, +9 authors, Arlene H Sharpe.
J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185    Free PMC article.
Highly Cited.
Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation.
Niloufar Safinia, Cristiano Scotta, +2 authors, Giovanna Lombardi.
Front Immunol, 2015 Sep 18; 6. PMID: 26379673    Free PMC article.
MALT1 is an intrinsic regulator of regulatory T cells.
A Brüstle, D Brenner, +4 authors, T W Mak.
Cell Death Differ, 2015 Sep 26; 24(7). PMID: 26405015    Free PMC article.
Mechanisms of immunological tolerance in central nervous system inflammatory demyelination.
Elisabeth R Mari, Jason N Moore, Guang-Xian Zhang, Abdolmohamad Rostami.
Clin Exp Neuroimmunol, 2015 Oct 02; 6(3). PMID: 26425145    Free PMC article.
Immunotherapy of Metastatic Colorectal Cancer: Prevailing Challenges and New Perspectives.
Timothy J Zumwalt, Ajay Goel.
Curr Colorectal Cancer Rep, 2015 Oct 07; 11(3). PMID: 26441489    Free PMC article.
In vivo induction of regulatory T cells for immune tolerance in hemophilia.
Xiaomei Wang, Cox Terhorst, Roland W Herzog.
Cell Immunol, 2015 Oct 12; 301. PMID: 26454643    Free PMC article.
Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients.
Fatina I Fadel, Eman A Elghoroury, +7 authors, Hala M Koura.
Int J Biomed Sci, 2015 Oct 29; 11(3). PMID: 26508906    Free PMC article.
Immune checkpoints and immunotherapy for colorectal cancer.
Preet Paul Singh, Piyush K Sharma, Gayathri Krishnan, A Craig Lockhart.
Gastroenterol Rep (Oxf), 2015 Oct 30; 3(4). PMID: 26510455    Free PMC article.
Regulatory T cells in the immunotherapy of melanoma.
Zhengxiao Ouyang, Hongwei Wu, +3 authors, Gang Huang.
Tumour Biol, 2015 Oct 31; 37(1). PMID: 26515336
TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner.
Kevin C Soares, Agnieszka A Rucki, +5 authors, Lei Zheng.
Oncotarget, 2015 Oct 31; 6(40). PMID: 26515728    Free PMC article.
Immunosuppressive mechanisms in glioblastoma.
Edjah K Nduom, Michael Weller, Amy B Heimberger.
Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516226    Free PMC article.
Highly Cited. Review.
Promises and paradoxes of regulatory T cells in inflammatory bowel disease.
James D Lord.
World J Gastroenterol, 2015 Nov 03; 21(40). PMID: 26523099    Free PMC article.
Regulatory T cells in cardiovascular diseases.
Xiao Meng, Jianmin Yang, +6 authors, Yun Zhang.
Nat Rev Cardiol, 2015 Nov 04; 13(3). PMID: 26525543
Highly Cited. Review.
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition.
Elizabeth I Buchbinder, Anupam Desai.
Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876    Free PMC article.
Highly Cited. Review.
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors.
Karishma R Rajani, Richard G Vile.
Viruses, 2015 Nov 19; 7(11). PMID: 26580645    Free PMC article.
Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.
Eva Rosenkranz, Ralf-Dieter Hilgers, +3 authors, Lothar Rink.
Eur J Nutr, 2015 Nov 22; 56(2). PMID: 26589301
Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy.
Silvia Gregori, Laura Passerini, Maria-Grazia Roncarolo.
Front Immunol, 2015 Dec 05; 6. PMID: 26635807    Free PMC article.
CTLA4Fcε, a novel soluble fusion protein that binds B7 molecules and the IgE receptors, and reduces human in vitro soluble CD23 production and lymphocyte proliferation.
Daniel Perez-Witzke, María Auxiliadora Miranda-García, +5 authors, Ramon Fernando Montano.
Immunology, 2016 Jan 24; 148(1). PMID: 26801967    Free PMC article.
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.
Christophe Pedros, Fanny Duguet, Abdelhadi Saoudi, Marianne Chabod.
World J Gastroenterol, 2016 Jan 27; 22(3). PMID: 26811641    Free PMC article.
Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition.
Joanna Brzostek, Nicholas R J Gascoigne, Vasily Rybakin.
Front Immunol, 2016 Feb 13; 7. PMID: 26870040    Free PMC article.
T Regulatory Cell Biology in Health and Disease.
Fayhan J Alroqi, Talal A Chatila.
Curr Allergy Asthma Rep, 2016 Mar 01; 16(4). PMID: 26922942    Free PMC article.
[Regulatory T-cells in systemic lupus erythematosus. IL-2 is decisive for loss of tolerance].
K Ohl, K Tenbrock.
Z Rheumatol, 2016 Mar 16; 75(3). PMID: 26975190
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
T cell receptor signalling in the control of regulatory T cell differentiation and function.
Ming O Li, Alexander Y Rudensky.
Nat Rev Immunol, 2016 Mar 31; 16(4). PMID: 27026074    Free PMC article.
Highly Cited. Review.
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.
Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, Kajsa Wing.
Proc Natl Acad Sci U S A, 2016 Apr 14; 113(17). PMID: 27071130    Free PMC article.
Highly Cited.
GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.
Liping Sun, Hao Jin, Hui Li.
Oncotarget, 2016 Apr 21; 7(27). PMID: 27095576    Free PMC article.
Medical treatment for gastro-entero-pancreatic neuroendocrine tumours.
Rossana Berardi, Francesca Morgese, +7 authors, Stefano Cascinu.
World J Gastrointest Oncol, 2016 Apr 21; 8(4). PMID: 27096034    Free PMC article.
Immunomodulatory effects of mesenchymal stromal cells-derived exosome.
Wancheng Chen, Yukai Huang, +8 authors, Yang Xiao.
Immunol Res, 2016 Apr 27; 64(4). PMID: 27115513
Highly Cited.
Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.
Adam N Odeh, Jerry W Simecka.
PLoS One, 2016 May 14; 11(5). PMID: 27175511    Free PMC article.
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Frank A Schildberg, Sarah R Klein, Gordon J Freeman, Arlene H Sharpe.
Immunity, 2016 May 19; 44(5). PMID: 27192563    Free PMC article.
Highly Cited. Review.
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
Hristina Nedelkovska, Alexander F Rosenberg, +9 authors, Steven H Bernstein.
PLoS One, 2016 May 27; 11(5). PMID: 27228053    Free PMC article.
Checkpoint Inhibitors and Their Application in Breast Cancer.
Davide Bedognetti, Cristina Maccalli, +2 authors, Barbara Seliger.
Breast Care (Basel), 2016 May 31; 11(2). PMID: 27239172    Free PMC article.
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.
Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion.
Front Immunol, 2016 Jun 01; 7. PMID: 27242797    Free PMC article.
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
Xin Li, Nicole V Acuff, +4 authors, Wendy T Watford.
J Biol Chem, 2016 Jun 05; 291(32). PMID: 27261457    Free PMC article.
Phenotypic and functional testing of circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab.
Janet Retseck, Robert VanderWeele, +3 authors, Ahmad A Tarhini.
J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330811    Free PMC article.
CTLA-4 Limits Anti-CD20-Mediated Tumor Regression.
Zhenhua Ren, Jingya Guo, +7 authors, Yang-Xin Fu.
Clin Cancer Res, 2016 Jun 30; 23(1). PMID: 27354469    Free PMC article.
Association of tumor necrosis factor-alpha 308G/A polymorphism with recurrent miscarriages in women.
Neha Sudhir, Badaruddoza, Archana Beri, Anupam Kaur.
J Hum Reprod Sci, 2016 Jul 07; 9(2). PMID: 27382232    Free PMC article.
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice.
Hyo Jin Park, Ji Hoon Oh, Sang-Jun Ha.
J Vis Exp, 2016 Jul 13; (112). PMID: 27404802    Free PMC article.
The Role of Skin Barrier in the Pathogenesis of Food Allergy.
Neema Izadi, Minnelly Luu, Peck Y Ong, Jonathan S Tam.
Children (Basel), 2015 Jan 01; 2(3). PMID: 27417371    Free PMC article.
Atypical Manifestation of LPS-Responsive Beige-Like Anchor Deficiency Syndrome as an Autoimmune Endocrine Disorder without Enteropathy and Immunodeficiency.
Shahrzad Bakhtiar, Frank Ruemmele, +5 authors, Ulrich Paetow.
Front Pediatr, 2016 Sep 30; 4. PMID: 27683652    Free PMC article.
Modulation of Phenotype and Function of Human CD4+CD25+ T Regulatory Lymphocytes Mediated by cAMP-Elevating Agents.
Antonella Riccomi, Valentina Gesa, +2 authors, Silvia Vendetti.
Front Immunol, 2016 Oct 06; 7. PMID: 27703455    Free PMC article.
Boosting Tumor-Specific Immunity Using PDT.
Nicole Maeding, Thomas Verwanger, Barbara Krammer.
Cancers (Basel), 2016 Oct 27; 8(10). PMID: 27782066    Free PMC article.
Lung Disease in Primary Antibody Deficiencies.
Edith Schussler, Mary B Beasley, Paul J Maglione.
J Allergy Clin Immunol Pract, 2016 Nov 12; 4(6). PMID: 27836055    Free PMC article.
T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective.
Mohammad Afzal Khan.
Mol Med, 2016 Nov 24; 22. PMID: 27878210    Free PMC article.
An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy.
Chie Miyabe, Yoshishige Miyabe, +4 authors, Sebastian Unizony.
Ann Rheum Dis, 2016 Dec 09; 76(5). PMID: 27927642    Free PMC article.
Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4+CD25+ Regulatory T Cells.
Da-Wei Wang, Ning Dong, +3 authors, Yong-Ming Yao.
Sci Rep, 2016 Dec 13; 6. PMID: 27941849    Free PMC article.
Prognostic value of circulating regulatory T cell subsets in untreated non-small cell lung cancer patients.
Athanasios Kotsakis, Filippos Koinis, +5 authors, Eleni-Kyriaki Vetsika.
Sci Rep, 2016 Dec 16; 6. PMID: 27976733    Free PMC article.
Regulatory T cells in cancer immunotherapy.
Atsushi Tanaka, Shimon Sakaguchi.
Cell Res, 2016 Dec 21; 27(1). PMID: 27995907    Free PMC article.
Highly Cited. Review.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger.
Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373    Free PMC article.
Highly Cited. Review.
Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
Patrizia Fasching, Martin Stradner, +2 authors, Johannes Fessler.
Molecules, 2017 Jan 19; 22(1). PMID: 28098832    Free PMC article.
Human IDO-competent, long-lived immunoregulatory dendritic cells induced by intracellular pathogen, and their fate in humanized mice.
Rajeev K Tyagi, Brodie Miles, +4 authors, Christopher W Cutler.
Sci Rep, 2017 Feb 16; 7. PMID: 28198424    Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors.
Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim.
Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545    Free PMC article.
Single vs. combination immunotherapeutic strategies for glioma.
Mayuri Chandran, Marianela Candolfi, +6 authors, Maria G Castro.
Expert Opin Biol Ther, 2017 Mar 14; 17(5). PMID: 28286975    Free PMC article.
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
Jennifer D Moy, Jessica M Moskovitz, Robert L Ferris.
Eur J Cancer, 2017 Mar 23; 76. PMID: 28324750    Free PMC article.
RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis.
Violeta Rus, Vinh Nguyen, +9 authors, Horea G Rus.
J Immunol, 2017 Mar 31; 198(10). PMID: 28356385    Free PMC article.
Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis.
A C Foks, J Kuiper.
Br J Pharmacol, 2017 Apr 04; 174(22). PMID: 28369782    Free PMC article.
UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.
Jake Wang, Curtis J Perry, +6 authors, Marcus Bosenberg.
Pigment Cell Melanoma Res, 2017 Apr 06; 30(4). PMID: 28379630    Free PMC article.
Highly Cited.
Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma.
Yago Pico de Coaña, Maria Wolodarski, +9 authors, Rolf Kiessling.
Oncotarget, 2017 Apr 21; 8(13). PMID: 28423487    Free PMC article.
Checkpoint inhibitors in hematological malignancies.
Chi Young Ok, Ken H Young.
J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851    Free PMC article.
Highly Cited. Review.
Mechanisms of Immune Tolerance in Leukemia and Lymphoma.
Emily K Curran, James Godfrey, Justin Kline.
Trends Immunol, 2017 May 18; 38(7). PMID: 28511816    Free PMC article.
Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs.
Cheol-Hun Son, Jaeho Bae, +2 authors, You-Soo Park.
Oncol Lett, 2017 May 20; 13(5). PMID: 28521478    Free PMC article.
Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.
Rebecca L Crepeau, Mandy L Ford.
Expert Opin Biol Ther, 2017 May 21; 17(8). PMID: 28525959    Free PMC article.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
Hwei-Fang Tsai, Ping-Ning Hsu.
J Biomed Sci, 2017 May 27; 24(1). PMID: 28545567    Free PMC article.
Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function.
Alexandre Bignon, Alan P Watt, Michelle A Linterman.
Front Immunol, 2017 May 31; 8. PMID: 28555139    Free PMC article.
Regulatory T cells in multiple sclerosis and myasthenia gravis.
K M Danikowski, S Jayaraman, B S Prabhakar.
J Neuroinflammation, 2017 Jun 11; 14(1). PMID: 28599652    Free PMC article.
Highly Cited. Review.
Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations.
N Verma, S O Burns, L S K Walker, D M Sansom.
Clin Exp Immunol, 2017 Jun 11; 190(1). PMID: 28600865    Free PMC article.
Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis.
Leonn Mendes Soares Pereira, Samara Tatielle Monteiro Gomes, Ricardo Ishak, Antonio Carlos Rosário Vallinoto.
Front Immunol, 2017 Jun 13; 8. PMID: 28603524    Free PMC article.
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Josiane Lilian Dos Santos Schiavinato, Rodrigo Haddad, +6 authors, Rodrigo Alexandre Panepucci.
Sci Rep, 2017 Jun 18; 7(1). PMID: 28620241    Free PMC article.
Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies.
Jeong A Park, Nai-Kong V Cheung.
Cancer Treat Rev, 2017 Jun 18; 58. PMID: 28622628    Free PMC article.
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Andrew Gibson, Lee Faulkner, +8 authors, Dean J Naisbitt.
J Immunol, 2017 Jul 09; 199(4). PMID: 28687658    Free PMC article.
The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells.
Alessandra Audia, Siobhan Conroy, Rainer Glass, Krishna P L Bhat.
Front Oncol, 2017 Jul 26; 7. PMID: 28740831    Free PMC article.
Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection.
Carsten Herskind, Frederik Wenz, Frank A Giordano.
Front Oncol, 2017 Aug 10; 7. PMID: 28791250    Free PMC article.
Drug delivery for the treatment of endometriosis and uterine fibroids.
David R Friend.
Drug Deliv Transl Res, 2017 Aug 23; 7(6). PMID: 28828592
Regulatory T cells in acute and chronic kidney diseases.
Rahul Sharma, Gilbert R Kinsey.
Am J Physiol Renal Physiol, 2017 Sep 08; 314(5). PMID: 28877881    Free PMC article.
Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy.
Sulsal Haque, Mahender Yellu, Jaskirat Randhawa, Nooshin Hashemi-Sadraei.
Drug Des Devel Ther, 2017 Sep 19; 11. PMID: 28919706    Free PMC article.
Immune Cell Population in Ovarian Tumor Microenvironment.
Dong Li Cai, Li-Ping Jin.
J Cancer, 2017 Sep 21; 8(15). PMID: 28928882    Free PMC article.
Chinese medicine Ginseng and Astragalus granules ameliorate autoimmune diabetes by upregulating both CD4+FoxP3+ and CD8+CD122+PD1+ regulatory T cells.
Yeshu Wang, Qingfeng Xie, +2 authors, Zhenhua Dai.
Oncotarget, 2017 Sep 28; 8(36). PMID: 28947964    Free PMC article.
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functions.
Bogusław Nedoszytko, Magdalena Lange, +10 authors, Roman Nowicki.
Postepy Dermatol Alergol, 2017 Sep 28; 34(4). PMID: 28951701    Free PMC article.
Checkpoint Inhibitors: Applications for Autoimmunity.
Anna S Tocheva, Adam Mor.
Curr Allergy Asthma Rep, 2017 Sep 29; 17(10). PMID: 28956259    Free PMC article.
Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection.
Marcia Bellon, Christophe Nicot.
Viruses, 2017 Oct 06; 9(10). PMID: 28981470    Free PMC article.
Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision.
Patrick R Adair, Yong Chan Kim, +2 authors, David W Scott.
Front Immunol, 2017 Oct 07; 8. PMID: 28983300    Free PMC article.
A Combination of Immune Checkpoint Inhibition with Metronomic Chemotherapy as a Way of Targeting Therapy-Resistant Cancer Cells.
Irina Kareva.
Int J Mol Sci, 2017 Oct 14; 18(10). PMID: 29027915    Free PMC article.
Forkhead-Box-P3 Gene Transfer in Human CD4+ T Conventional Cells for the Generation of Stable and Efficient Regulatory T Cells, Suitable for Immune Modulatory Therapy.
Laura Passerini, Rosa Bacchetta.
Front Immunol, 2017 Oct 28; 8. PMID: 29075264    Free PMC article.
A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection.
Feifei Qiu, Huazhen Liu, +2 authors, Zhenhua Dai.
Front Immunol, 2017 Nov 24; 8. PMID: 29167674    Free PMC article.
Advances in T-cell checkpoint immunotherapy for head and neck squamous cell carcinoma.
Xinmeng Qi, Bo Jia, Xue Zhao, Dan Yu.
Onco Targets Ther, 2017 Dec 15; 10. PMID: 29238207    Free PMC article.
Synthetic Nanoparticles That Promote Tumor Necrosis Factor Receptor 2 Expressing Regulatory T Cells in the Lung and Resistance to Allergic Airways Inflammation.
Rohimah Mohamud, Jeanne S LeMasurier, +5 authors, Magdalena Plebanski.
Front Immunol, 2018 Jan 10; 8. PMID: 29312323    Free PMC article.
Contribution of Adipose Tissue to Development of Cancer.
Alyssa J Cozzo, Ashley M Fuller, Liza Makowski.
Compr Physiol, 2018 Jan 23; 8(1). PMID: 29357128    Free PMC article.
Highly Cited. Review.
Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis.
B L Adler, M K Pezhouh, +15 authors, R A Anders.
J Intern Med, 2018 Feb 22; 283(6). PMID: 29464806    Free PMC article.
Human FOXP3+ T regulatory cell heterogeneity.
Audrey Mohr, Rajneesh Malhotra, +2 authors, Makoto Miyara.
Clin Transl Immunology, 2018 Feb 28; 7(1). PMID: 29484183    Free PMC article.
Highly Cited. Review.
Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.
Mohamed B Ezzelarab, Lien Lu, +2 authors, Angus W Thomson.
Front Immunol, 2018 Mar 10; 9. PMID: 29520267    Free PMC article.
Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells.
Niloufar Safinia, Nathali Grageda, +5 authors, Giovanna Lombardi.
Front Immunol, 2018 Mar 15; 9. PMID: 29535728    Free PMC article.
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells.
Thomas Menter, Alexandar Tzankov.
Front Oncol, 2018 Mar 23; 8. PMID: 29564225    Free PMC article.
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Tomomi Kiyota, Jatin Machhi, +5 authors, Howard E Gendelman.
J Neuroimmunol, 2018 Mar 27; 319. PMID: 29573847    Free PMC article.
Regulatory T Cells As Potential Targets for HIV Cure Research.
Adam J Kleinman, Ranjit Sivanandham, +2 authors, Cristian Apetrei.
Front Immunol, 2018 May 01; 9. PMID: 29706961    Free PMC article.
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
Charlotte Schwab, Annemarie Gabrysch, +78 authors, Bodo Grimbacher.
J Allergy Clin Immunol, 2018 May 08; 142(6). PMID: 29729943    Free PMC article.
Highly Cited.
Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC).
Young Kwang Chae, Ayush Arya, +4 authors, Francis Giles.
J Immunother Cancer, 2018 May 18; 6(1). PMID: 29769148    Free PMC article.
Highly Cited. Review.
Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4.
Saisha A Nalawade, Niannian Ji, +3 authors, Thomas G Forsthuber.
Cell Immunol, 2018 May 24; 331. PMID: 29789121    Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
Immune checkpoint therapy in liver cancer.
Feng Xu, Tianqiang Jin, Yuwen Zhu, Chaoliu Dai.
J Exp Clin Cancer Res, 2018 May 31; 37(1). PMID: 29843754    Free PMC article.
Highly Cited. Review.
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study.
Ethan M Shevach.
Front Immunol, 2018 Jun 06; 9. PMID: 29868011    Free PMC article.
Highly Cited. Review.
Targeting the Immune Microenvironment in Acute Myeloid Leukemia: A Focus on T Cell Immunity.
Adam J Lamble, Evan F Lind.
Front Oncol, 2018 Jun 29; 8. PMID: 29951373    Free PMC article.
Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response.
Krista Stockenhuber, Ahmed N Hegazy, +9 authors, Fiona Powrie.
J Exp Med, 2018 Jul 08; 215(8). PMID: 29980582    Free PMC article.
Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells.
Jiayun Hu, Jiajie Chen, +3 authors, Kunmei Ji.
Clin Transl Allergy, 2018 Jul 22; 8. PMID: 30026908    Free PMC article.
Regulatory Role of CD4+ T Cells in Myocarditis.
Daria Vdovenko, Urs Eriksson.
J Immunol Res, 2018 Jul 24; 2018. PMID: 30035131    Free PMC article.
Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration.
Ayman Oweida, Mohammad K Hararah, +14 authors, Sana D Karam.
Clin Cancer Res, 2018 Jul 26; 24(21). PMID: 30042205    Free PMC article.
Highly Cited.
Elucidating T Cell Activation-Dependent Mechanisms for Bifurcation of Regulatory and Effector T Cell Differentiation by Multidimensional and Single-Cell Analysis.
Alla Bradley, Tetsuo Hashimoto, Masahiro Ono.
Front Immunol, 2018 Aug 01; 9. PMID: 30061879    Free PMC article.
Complex interplay between tumor microenvironment and cancer therapy.
Minhong Shen, Yibin Kang.
Front Med, 2018 Aug 12; 12(4). PMID: 30097962
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.
Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül.
Front Immunol, 2018 Aug 31; 9. PMID: 30158932    Free PMC article.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.
Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar.
J Autoimmun, 2018 Sep 04; 95. PMID: 30174217    Free PMC article.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
Immune checkpoint inhibitors for hepatocellular carcinoma.
Christopher E Jensen, Arturo Loaiza-Bonilla, Paula A Bonilla-Reyes.
Hepat Oncol, 2016 Aug 01; 3(3). PMID: 30191042    Free PMC article.
Characterization of CTLA4 Trafficking and Implications for Its Function.
Sahamoddin Khailaie, Behzad Rowshanravan, +6 authors, Michael Meyer-Hermann.
Biophys J, 2018 Sep 17; 115(7). PMID: 30219287    Free PMC article.
Not All Immune Checkpoints Are Created Equal.
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger.
Front Immunol, 2018 Sep 21; 9. PMID: 30233564    Free PMC article.
Highly Cited. Review.
Regulatory B and T lymphocytes in multiple sclerosis: friends or foes?
Georgios K Vasileiadis, Efthymios Dardiotis, +5 authors, Georgios M Hadjigeorgiou.
Auto Immun Highlights, 2018 Nov 12; 9(1). PMID: 30415321    Free PMC article.
Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny.
Mark R Dowling, Andrey Kan, +3 authors, Edwin D Hawkins.
Front Immunol, 2018 Nov 15; 9. PMID: 30425712    Free PMC article.
Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model.
Daniel R Holohan, Frédéric Van Gool, Jeffrey A Bluestone.
PLoS One, 2019 Oct 28; 14(10). PMID: 31647813    Free PMC article.
Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story.
Geny Piro, Carmine Carbone, +6 authors, Giampaolo Tortora.
Cancers (Basel), 2019 Oct 30; 11(10). PMID: 31658667    Free PMC article.
The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma.
Peng Liao, Haofan Wang, +2 authors, Xin-Hua Liang.
Front Immunol, 2019 Nov 12; 10. PMID: 31708918    Free PMC article.
Regulatory T Cell Development in the Thymus.
David L Owen, Louisa E Sjaastad, Michael A Farrar.
J Immunol, 2019 Oct 09; 203(8). PMID: 31591259    Free PMC article.
Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors.
Sophia C Weinmann, David S Pisetsky.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816080    Free PMC article.
Arthritis in children with LRBA deficiency - case report and literature review.
Rotem Semo Oz, Melissa S Tesher.
Pediatr Rheumatol Online J, 2019 Dec 19; 17(1). PMID: 31847838    Free PMC article.
Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells.
Yang Luo, Youqiu Xue, +5 authors, Song Guo Zheng.
Cell Rep, 2019 Feb 14; 26(7). PMID: 30759396    Free PMC article.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation.
Antonella Mancusi, Sara Piccinelli, Andrea Velardi, Antonio Pierini.
Front Immunol, 2020 Jan 11; 10. PMID: 31921162    Free PMC article.
Costimulation Blockade in Kidney Transplant Recipients.
Marieke van der Zwan, Dennis A Hesselink, Martijn W F van den Hoogen, Carla C Baan.
Drugs, 2019 Nov 22; 80(1). PMID: 31749062    Free PMC article.
Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+ CD25+ regulatory T cells.
Yun Ge, Man Huang, +2 authors, Yong-Ming Yao.
J Cell Mol Med, 2019 Dec 28; 24(2). PMID: 31880383    Free PMC article.
The Potential Role of Inhibitory Receptors in the Treatment of Psoriasis.
Neha Shah, Sabina Sandigursky, Adam Mor.
Bull Hosp Jt Dis (2013), 2017 Sep 14; 75(3). PMID: 28902599    Free PMC article.
Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms.
Mikayel Mkrtichyan, Yana G Najjar, +5 authors, Samir N Khleif.
Eur J Immunol, 2011 Jun 29; 41(10). PMID: 21710477    Free PMC article.
Immune checkpoint-based therapy in myeloid malignancies: a promise yet to be fulfilled.
Jan Philipp Bewersdorf, Maximilian Stahl, Amer M Zeidan.
Expert Rev Anticancer Ther, 2019 Mar 20; 19(5). PMID: 30887841    Free PMC article.
Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.
Sara Saab, Hussein Zalzale, +3 authors, Humam Kadara.
Front Immunol, 2020 Mar 03; 11. PMID: 32117295    Free PMC article.
NK Cell-Based Immune Checkpoint Inhibition.
Muhammad Khan, Sumbal Arooj, Hua Wang.
Front Immunol, 2020 Mar 03; 11. PMID: 32117298    Free PMC article.
Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance.
Radhika R Gudi, Subha Karumuthil-Melethil, +2 authors, Chenthamarakshan Vasu.
Sci Rep, 2019 Aug 21; 9(1). PMID: 31427630    Free PMC article.
T lymphocyte-targeted immune checkpoint modulation in glioma.
William James Kelly, Amber Jin Giles, Mark Gilbert.
J Immunother Cancer, 2020 Feb 14; 8(1). PMID: 32051289    Free PMC article.
Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers.
Anu Sharma, Sumit K Subudhi, +6 authors, Padmanee Sharma.
Clin Cancer Res, 2018 Jul 29; 25(4). PMID: 30054281    Free PMC article.
Highly Cited.
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.
Chien-Chun Steven Pai, Donald M Simons, +22 authors, Lawrence Fong.
J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530991    Free PMC article.
Human CD8+HLA-DR+ Regulatory T Cells, Similarly to Classical CD4+Foxp3+ Cells, Suppress Immune Responses via PD-1/PD-L1 Axis.
Andres Machicote, Santiago Belén, +2 authors, Leonardo Fainboim.
Front Immunol, 2018 Dec 18; 9. PMID: 30555473    Free PMC article.
Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells.
Rui-Qi Chang, Jun Shao, +3 authors, Ming-Qing Li.
Cell Death Dis, 2019 Feb 10; 10(2). PMID: 30737372    Free PMC article.
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells.
Jessica Bourque, Daniel Hawiger.
Crit Rev Immunol, 2019 Feb 23; 38(5). PMID: 30792568    Free PMC article.
Highly Cited. Review.
Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy.
Ee Lyn Lim, Klaus Okkenhaug.
Immunology, 2019 May 21; 157(3). PMID: 31107985    Free PMC article.
Defects of CTLA-4 Are Associated with Regulatory T Cells in Myasthenia Gravis Implicated by Intravenous Immunoglobulin Therapy.
Wenhua Xu, Mingshan Ren, +5 authors, Jiajun Cui.
Mediators Inflamm, 2020 Mar 10; 2020. PMID: 32148437    Free PMC article.
A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: the Ipi-Glio trial protocol.
Nicholas F Brown, Stasya M Ng, +8 authors, Paul Mulholland.
BMC Cancer, 2020 Mar 14; 20(1). PMID: 32164579    Free PMC article.
Workup and Management of Immune-Mediated Colitis in Patients Treated with Immune Checkpoint Inhibitors.
Bhavana Pendurthi Singh, John L Marshall, Aiwu Ruth He.
Oncologist, 2020 Mar 13; 25(3). PMID: 32162824    Free PMC article.
Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies.
Yun Liu, Jianfeng Guo, Leaf Huang.
Theranostics, 2020 Mar 21; 10(7). PMID: 32194857    Free PMC article.
Immunosuppressive mechanisms during viral infectious diseases.
Ghanashyam Sarikonda, Matthias G von Herrath.
Methods Mol Biol, 2010 Oct 14; 677. PMID: 20941625    Free PMC article.
Development of immune checkpoint therapy for cancer.
Jill M Fritz, Michael J Lenardo.
J Exp Med, 2019 May 10; 216(6). PMID: 31068379    Free PMC article.
Highly Cited. Review.
Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells.
Qiaohuang Zeng, Feifei Qiu, +5 authors, Zhenhua Dai.
Front Immunol, 2019 Apr 17; 10. PMID: 30988670    Free PMC article.
CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade.
Josselyn E Garcia-Perez, Ryan M Baxter, +7 authors, Elena W Y Hsieh.
Front Immunol, 2019 Jun 04; 10. PMID: 31156616    Free PMC article.
Mechanisms of checkpoint inhibition-induced adverse events.
P Urwyler, I Earnshaw, +9 authors, S Papa.
Clin Exp Immunol, 2020 Jan 29; 200(2). PMID: 31989585    Free PMC article.
Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells.
Andreas von Knethen, Ulrike Heinicke, +2 authors, Bernhard Brüne.
Int J Mol Sci, 2020 Apr 03; 21(7). PMID: 32235291    Free PMC article.
Regulatory T Cells: the Many Faces of Foxp3.
Peter Georgiev, Louis-Marie Charbonnier, Talal A Chatila.
J Clin Immunol, 2019 Sep 04; 39(7). PMID: 31478130    Free PMC article.
Regulatory T-cell therapy in Crohn's disease: challenges and advances.
Jennie N Clough, Omer S Omer, +2 authors, Peter M Irving.
Gut, 2020 Jan 26; 69(5). PMID: 31980447    Free PMC article.
Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity - A Mini-Review.
Weikan Wang, Rachel Thomas, Olga Sizova, Dong-Ming Su.
Front Immunol, 2020 May 20; 11. PMID: 32425946    Free PMC article.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
Facing SARS-CoV-2 outbreak in immunotherapy era.
Fabrizio Citarella, Marco Russano, +4 authors, Daniele Santini.
Future Oncol, 2020 May 30; 16(20). PMID: 32468851    Free PMC article.
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.
Rodolfo Daniel Cervantes-Villagrana, Damaris Albores-García, Alberto Rafael Cervantes-Villagrana, Sara Judit García-Acevez.
Signal Transduct Target Ther, 2020 Jun 20; 5(1). PMID: 32555170    Free PMC article.
High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot.
Simon P Keam, Heloise Halse, +13 authors, Paul J Neeson.
J Immunother Cancer, 2020 Jun 26; 8(1). PMID: 32581061    Free PMC article.
Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells.
Julia D Berkson, Chloe K Slichter, +10 authors, Martin Prlic.
Immunohorizons, 2020 Jan 25; 4(1). PMID: 31974109    Free PMC article.
Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases.
Ning Huang, Hongbin Chi, Jie Qiao.
Front Immunol, 2020 Jul 18; 11. PMID: 32676072    Free PMC article.
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment.
Giuseppa Augello, Maria R Emma, +4 authors, Melchiorre Cervello.
Cells, 2020 Jun 13; 9(6). PMID: 32526891    Free PMC article.
Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.
Diwakar Davar, Hassane M Zarour.
Methods Mol Biol, 2019 Sep 11; 2055. PMID: 31502146    Free PMC article.
Primary B-cell immunodeficiencies.
Tukisa Smith, Charlotte Cunningham-Rundles.
Hum Immunol, 2018 Oct 26; 80(6). PMID: 30359632    Free PMC article.
Harnessing NK Cell Checkpoint-Modulating Immunotherapies.
Sachin Kumar Singh Chauhan, Ulrike Koehl, Stephan Kloess.
Cancers (Basel), 2020 Jul 10; 12(7). PMID: 32640575    Free PMC article.
Prenatal exposure of staphylococcal enterotoxin B attenuates the development and function of blood regulatory T cells to repeated staphylococcal enterotoxin B exposure in adult offspring rats.
Shu-Xian Gao, Jing Sun, +7 authors, Jun-Chang Guan.
J Med Microbiol, 2020 Feb 12; 69(4). PMID: 32043953    Free PMC article.
Scientifically based combination therapies with immuno-oncology checkpoint inhibitors.
Hui Yi Chew, Riccardo Dolcetti, Fiona Simpson.
Br J Clin Pharmacol, 2020 May 07; 86(9). PMID: 32372470    Free PMC article.
BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations.
Tao Shen, Shengnan Jia, +4 authors, Liping Cao.
iScience, 2020 Aug 18; 23(8). PMID: 32798974    Free PMC article.
Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma.
Shaoping Shen, Ling Chen, +8 authors, Tianyi Liu.
Cancer Biol Med, 2020 Sep 19; 17(3). PMID: 32944390    Free PMC article.
Human regulatory T cells (Treg) and their response to cancer.
Theresa L Whiteside.
Expert Rev Precis Med Drug Dev, 2019 Jan 01; 4(4). PMID: 32953989    Free PMC article.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma.
Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns.
Front Oncol, 2019 Mar 12; 8. PMID: 30854331    Free PMC article.
Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives.
Diego De Goycoechea, Gregoire Stalder, Filipe Martins, Michel A Duchosal.
J Oncol, 2019 Jun 18; 2019. PMID: 31205470    Free PMC article.
A Review of Efficacy and Safety of Checkpoint Inhibitor for the Treatment of Acute Myeloid Leukemia.
Dan Liao, Mengyao Wang, +2 authors, Ting Niu.
Front Pharmacol, 2019 Jun 28; 10. PMID: 31244654    Free PMC article.
AP-1 Transcription Factors as Regulators of Immune Responses in Cancer.
Vasileios Atsaves, Vasiliki Leventaki, George Z Rassidakis, Francois X Claret.
Cancers (Basel), 2019 Jul 26; 11(7). PMID: 31340499    Free PMC article.
Immunotherapy for hepatocellular carcinoma: recent advances and future perspectives.
Weiqi Xu, Ken Liu, +4 authors, Jiansong Ji.
Ther Adv Med Oncol, 2019 Aug 07; 11. PMID: 31384311    Free PMC article.
Meta-analysis of transcriptomic variation in T-cell populations reveals both variable and consistent signatures of gene expression and splicing.
Caleb M Radens, Davia Blake, +2 authors, Kristen W Lynch.
RNA, 2020 Jun 20; 26(10). PMID: 32554554    Free PMC article.
Differential CD4 T Regulatory Cell Phenotype Induced by Andes Hantavirus Glycoprotein.
Farides Saavedra, Jose L Garrido, +8 authors, Maria Ines Barria.
Front Cell Infect Microbiol, 2020 Sep 29; 10. PMID: 32984065    Free PMC article.
Sarcomatoid renal cell carcinoma: biology, natural history and management.
Kyle A Blum, Sounak Gupta, +5 authors, A Ari Hakimi.
Nat Rev Urol, 2020 Oct 15; 17(12). PMID: 33051619    Free PMC article.
Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.
S C Sasson, J J Zaunders, +17 authors, A D Kelleher.
Clin Exp Immunol, 2020 Aug 01; 202(3). PMID: 32734627    Free PMC article.
Human CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism.
Jessica R Magid-Bernstein, Christine M Rohowsky-Kochan.
J Interferon Cytokine Res, 2017 Apr 08; 37(4). PMID: 28387597    Free PMC article.
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.
Miguel F Sanmamed, Lieping Chen.
Cell, 2018 Oct 06; 175(2). PMID: 30290139    Free PMC article.
Highly Cited. Review.
Constitutive reduction in the checkpoint inhibitor, CTLA-4, does not accelerate SLE in NZM 2328 mice.
William Stohl, Ning Yu, +2 authors, Chaim O Jacob.
Lupus Sci Med, 2019 Jun 07; 6(1). PMID: 31168399    Free PMC article.
CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4.
Neil Halliday, Cayman Williams, +9 authors, David M Sansom.
Front Immunol, 2020 Dec 29; 11. PMID: 33363541    Free PMC article.
Discovery and Function of B-Cell IgD Low (BDL) B Cells in Immune Tolerance.
Mohamed I Khalil, Cody J Gurski, +2 authors, Bonnie N Dittel.
J Mol Biol, 2020 Jul 03; 433(1). PMID: 32615130    Free PMC article.
Beyond T-Cells: Functional Characterization of CTLA-4 Expression in Immune and Non-Immune Cell Types.
Damilola Oyewole-Said, Vanaja Konduri, +3 authors, William K Decker.
Front Immunol, 2021 Jan 02; 11. PMID: 33384695    Free PMC article.
The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription.
Jing Guo, Zhonghui Xue, +9 authors, Lie Wang.
Cell Mol Immunol, 2019 Sep 13; 17(12). PMID: 31511645    Free PMC article.
Increased infiltration of regulatory T cells in hepatocellular carcinoma of patients with hepatitis B virus pre-S2 mutant.
Chiao-Fang Teng, Tsai-Chung Li, +8 authors, Long-Bin Jeng.
Sci Rep, 2021 Jan 15; 11(1). PMID: 33441885    Free PMC article.
Photothermal therapies to improve immune checkpoint blockade for cancer.
Preethi B Balakrishnan, Elizabeth E Sweeney, Anvitha S Ramanujam, Rohan Fernandes.
Int J Hyperthermia, 2021 Jan 12; 37(3). PMID: 33426992    Free PMC article.
MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice.
John E Schjenken, Lachlan M Moldenhauer, +6 authors, Sarah A Robertson.
Mucosal Immunol, 2020 Jan 29; 13(4). PMID: 31988469
Classification of T-cell activation via autofluorescence lifetime imaging.
Alex J Walsh, Katherine P Mueller, +7 authors, Melissa C Skala.
Nat Biomed Eng, 2020 Jul 29; 5(1). PMID: 32719514    Free PMC article.
Intestinal Regulatory T Cells.
Vanessa R Figliuolo da Paz, Deepa R Jamwal, Pawel R Kiela.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523448
Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment.
Varun Sasidharan Nair, Reem Saleh, +2 authors, Eyad Elkord.
Cancer Immunol Immunother, 2021 Feb 04; 70(8). PMID: 33532902    Free PMC article.
Systemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells.
Eun Jee Kim, Joon Ye Kim, +6 authors, Beom Seok Kim.
Yonsei Med J, 2021 Feb 03; 62(2). PMID: 33527793    Free PMC article.
B Cells in Patients With Melanoma: Implications for Treatment With Checkpoint Inhibitor Antibodies.
Zena N Willsmore, Robert J Harris, +21 authors, Sophia N Karagiannis.
Front Immunol, 2021 Feb 12; 11. PMID: 33569063    Free PMC article.
Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity.
Allan Relecom, Maysaloun Merhi, +4 authors, Said Dermime.
J Exp Clin Cancer Res, 2021 Feb 20; 40(1). PMID: 33602280    Free PMC article.
Strategies for Liver Transplantation Tolerance.
Filip Cvetkovski, J Mark Hexham, Erik Berglund.
Int J Mol Sci, 2021 Mar 07; 22(5). PMID: 33668238    Free PMC article.
Impaired Butyrate Induced Regulation of T Cell Surface Expression of CTLA-4 in Patients with Ulcerative Colitis.
Maria K Magnusson, Alexander Vidal, +4 authors, Lena Öhman.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33802979    Free PMC article.
Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma.
Sanghwa Kim, Minji Lee, +7 authors, Haeng Ran Seo.
J Exp Clin Cancer Res, 2021 Apr 12; 40(1). PMID: 33838671    Free PMC article.
Metabolism and immunity in breast cancer.
Deyu Zhang, Xiaojie Xu, Qinong Ye.
Front Med, 2020 Oct 20; 15(2). PMID: 33074528
Metabolic barriers to cancer immunotherapy.
Kristin DePeaux, Greg M Delgoffe.
Nat Rev Immunol, 2021 May 01; 21(12). PMID: 33927375    Free PMC article.
Soluble immune checkpoint molecules: Serum markers for cancer diagnosis and prognosis.
Rituparna Chakrabarti, Bhavya Kapse, Gayatri Mukherjee.
Cancer Rep (Hoboken), 2020 Jul 29; 2(4). PMID: 32721130    Free PMC article.
Treatment of rheumatic immune-related adverse events due to cancer immunotherapy with immune checkpoint inhibitors-is it time for a paradigm shift?
Katerina Chatzidionysiou, Matina Liapi, +2 authors, Anca Catrina.
Clin Rheumatol, 2020 Sep 30; 40(5). PMID: 32989505    Free PMC article.
Interfaces between cellular responses to DNA damage and cancer immunotherapy.
Domenic Pilger, Leonard W Seymour, Stephen P Jackson.
Genes Dev, 2021 Apr 24; 35(9-10). PMID: 33888558    Free PMC article.
Mechanisms and Management of Immune Checkpoint Inhibitor-Related Cardiac Adverse Events.
Hiroshi Kadowaki, Hiroshi Akazawa, Junichi Ishida, Issei Komuro.
JMA J, 2021 May 18; 4(2). PMID: 33997442    Free PMC article.
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy.
Amrita Basu, Ganesan Ramamoorthi, +7 authors, Krithika Kodumudi.
Front Immunol, 2021 May 21; 12. PMID: 34012451    Free PMC article.
Current Prospects for Treatment of Solid Tumors via Photodynamic, Photothermal, or Ionizing Radiation Therapies Combined with Immune Checkpoint Inhibition (A Review).
Sanjay Anand, Timothy A Chan, Tayyaba Hasan, Edward V Maytin.
Pharmaceuticals (Basel), 2021 Jun 03; 14(5). PMID: 34068491    Free PMC article.
Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development.
Seyed Hossein Kiaie, Mohammad Javad Sanaei, +5 authors, Behzad Baradaran.
Acta Pharm Sin B, 2021 Jun 08; 11(5). PMID: 34094821    Free PMC article.
Long non-coding RNAs XIST and MALAT1 hijack the PD-L1 regulatory signaling pathway in breast cancer subtypes.
Amany Samir, Reda Abdel Tawab, Hend M El Tayebi.
Oncol Lett, 2021 Jun 22; 22(2). PMID: 34149904    Free PMC article.
Multipotent adult progenitor cells induce regulatory T cells and promote their suppressive phenotype via TGFβ and monocyte-dependent mechanisms.
Alice Valentin-Torres, Cora Day, +5 authors, Anthony E Ting.
Sci Rep, 2021 Jul 02; 11(1). PMID: 34193955    Free PMC article.
Regulatory T Cells-Related Genes Are under DNA Methylation Influence.
Magdalena Piotrowska, Mateusz Gliwiński, Piotr Trzonkowski, Dorota Iwaszkiewicz-Grzes.
Int J Mol Sci, 2021 Jul 21; 22(13). PMID: 34281195    Free PMC article.
In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse.
Gil-Ran Kim, Won-Ju Kim, +6 authors, Je-Min Choi.
Adv Sci (Weinh), 2021 Jul 27; 8(14). PMID: 34306974    Free PMC article.
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells.
Murat Tekguc, James Badger Wing, +2 authors, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2021 Jul 25; 118(30). PMID: 34301886    Free PMC article.
Immune Checkpoints in Cancers: From Signaling to the Clinic.
Céline Pisibon, Amira Ouertani, +2 authors, Yann Cheli.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572799    Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang.
Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187    Free PMC article.
The Combination of Radiotherapy With Immunotherapy and Potential Predictive Biomarkers for Treatment of Non-Small Cell Lung Cancer Patients.
Lu Meng, Jianfang Xu, +3 authors, Xiaomei Gong.
Front Immunol, 2021 Oct 09; 12. PMID: 34621270    Free PMC article.
Regulatory T Cells in Chronic Heart Failure.
Yuzhi Lu, Ni Xia, Xiang Cheng.
Front Immunol, 2021 Oct 12; 12. PMID: 34630414    Free PMC article.
Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells.
Christina B Schroeter, Niklas Huntemann, +5 authors, Tobias Ruck.
Front Immunol, 2021 Oct 26; 12. PMID: 34691057    Free PMC article.
Homozygous duplication identified by whole genome sequencing causes LRBA deficiency.
Daniele Merico, Yehonatan Pasternak, +12 authors, Chaim M Roifman.
NPJ Genom Med, 2021 Nov 20; 6(1). PMID: 34795304    Free PMC article.
Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens.
Ryuta Uraki, Masaki Imai, +5 authors, Sayuri Yamazaki.
PLoS Pathog, 2021 Dec 10; 17(12). PMID: 34882757    Free PMC article.
Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy.
R R Maniyar, S Chakraborty, +4 authors, R K Tiwari.
Adv Exp Med Biol, 2021 Dec 11; 1350. PMID: 34888847
Steatosis, Steatohepatitis and Cancer Immunotherapy: An Intricate Story.
Mauro Cataldi, Federica Manco, Giovanni Tarantino.
Int J Mol Sci, 2021 Dec 11; 22(23). PMID: 34884762    Free PMC article.
Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy.
Nicolas Jacquelot, Maryam Ghaedi, +3 authors, Pamela S Ohashi.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885076    Free PMC article.
The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function.
Praveen Prakhar, Jaylene Alvarez-DelValle, +4 authors, Jung-Hyun Park.
JCI Insight, 2021 Nov 09; 6(21). PMID: 34747370    Free PMC article.
Targeting metabotropic glutamate receptor 4 for cancer immunotherapy.
Zhuoya Wan, Runzi Sun, +14 authors, Song Li.
Sci Adv, 2021 Dec 11; 7(50). PMID: 34890233    Free PMC article.
Early Myeloid Derived Suppressor Cells (eMDSCs) Are Associated With High Donor Myeloid Chimerism Following Haploidentical HSCT for Sickle Cell Disease.
Deepali K Bhat, Purevdorj B Olkhanud, +11 authors, Courtney D Fitzhugh.
Front Immunol, 2021 Dec 18; 12. PMID: 34917079    Free PMC article.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial.
Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg.
Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915
Pathogenesis of Autoimmune Hepatitis-Cellular and Molecular Mechanisms.
Claudia Sirbe, Gelu Simu, +2 authors, Tudor Lucian Pop.
Int J Mol Sci, 2021 Dec 25; 22(24). PMID: 34948375    Free PMC article.
A Promising Treatment Strategy for Lung Cancer: A Combination of Radiotherapy and Immunotherapy.
Yuhei Miyasaka, Hiro Sato, +3 authors, Tatsuya Ohno.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008367    Free PMC article.
Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma.
A-Reum Kim, Seong Jin Choi, +9 authors, Eui-Cheol Shin.
Oncoimmunology, 2022 Jan 18; 11(1). PMID: 35036078    Free PMC article.
Factors Determining Long-Term Antitumor Responses to Immune Checkpoint Blockade Therapy in Melanoma.
Kimberly Loo, James W Smithy, Michael A Postow, Allison Betof Warner.
Front Immunol, 2022 Jan 29; 12. PMID: 35087529    Free PMC article.
Longitudinal monitoring of mRNA levels of regulatory T cell biomarkers by using non-invasive strategies to predict outcome in renal transplantation.
Angelica Canossi, Samuele Iesari, +7 authors, Francesco Pisani.
BMC Nephrol, 2022 Feb 04; 23(1). PMID: 35109826    Free PMC article.
Monoclonal Antibodies to CTLA-4 with Focus on Ipilimumab.
Grazia Graziani, Lucia Lisi, Lucio Tentori, Pierluigi Navarra.
Exp Suppl, 2022 Feb 16; 113. PMID: 35165868
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1.
Yuwei Hao, Matthew C Cook.
Front Immunol, 2022 Feb 15; 12. PMID: 35154081    Free PMC article.
Primary immune regulatory disorders: Undiagnosed needles in the haystack?
Aisling M Flinn, Andrew R Gennery.
Orphanet J Rare Dis, 2022 Mar 05; 17(1). PMID: 35241125    Free PMC article.
Stratification of COVID-19 patients based on quantitative immune-related gene expression in whole blood.
Josefine Persson, Björn Andersson, +8 authors, Ali M Harandi.
Mol Immunol, 2022 Mar 11; 145. PMID: 35272104    Free PMC article.
The Immunogenetics of Alopecia areata.
Fateme Rajabi, Fahimeh Abdollahimajd, +2 authors, Alireza Firooz.
Adv Exp Med Biol, 2022 Mar 15; 1367. PMID: 35286691
Immunogenetics of Lupus Erythematosus.
Begüm Ünlü, Ümit Türsen, +2 authors, Fateme Rajabi.
Adv Exp Med Biol, 2022 Mar 15; 1367. PMID: 35286698
Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy.
Michael P Vincent, Justin O Navidzadeh, Sharan Bobbala, Evan A Scott.
Cancer Cell, 2022 Feb 13; 40(3). PMID: 35148814    Free PMC article.
Immunological Classification of Tumor Types and Advances in Precision Combination Immunotherapy.
Xiufang Ren, Songyi Guo, +3 authors, Xianghong Yang.
Front Immunol, 2022 Mar 18; 13. PMID: 35296094    Free PMC article.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.
Karin H Simons, Alwin de Jong, +3 authors, Paul H A Quax.
Nat Rev Cardiol, 2019 Feb 17; 16(6). PMID: 30770894
The Role of Myeloid Cells in Hepatotoxicity Related to Cancer Immunotherapy.
Cathrin L C Gudd, Lucia A Possamai.
Cancers (Basel), 2022 Apr 24; 14(8). PMID: 35454819    Free PMC article.
Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue.
Zuwena A Richardson, Claire Deleage, +12 authors, Paul U Cameron.
J Immunol Methods, 2021 Dec 06; 501. PMID: 34863818    Free PMC article.
Immune checkpoint inhibitors for the treatment of melanoma.
Francesco Sabbatino, Luigi Liguori, Stefano Pepe, Soldano Ferrone.
Expert Opin Biol Ther, 2022 Feb 09; 22(5). PMID: 35130816    Free PMC article.
Comprehensive analysis of ZFPM2-AS1 prognostic value, immune microenvironment, drug sensitivity, and co-expression network: from gastric adenocarcinoma to pan-cancers.
Di Chen, Mengmeng Wang, Xin Jiang, Zhifan Xiong.
Discov Oncol, 2022 Apr 14; 13(1). PMID: 35416526    Free PMC article.
Correlations between Circulating and Tumor-Infiltrating CD4+ T Cell Subsets with Immune Checkpoints in Colorectal Cancer.
Mohammad A Al-Mterin, Khaled Murshed, Eyad Elkord.
Vaccines (Basel), 2022 Apr 24; 10(4). PMID: 35455287    Free PMC article.
Glioblastoma: Pitfalls and Opportunities of Immunotherapeutic Combinations.
Marcin Niedbała, Katarzyna Malarz, +2 authors, Wojciech Kaspera.
Onco Targets Ther, 2022 May 06; 15. PMID: 35509452    Free PMC article.
The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy.
Peter John, Marc C Pulanco, +4 authors, Xingxing Zang.
Nat Commun, 2022 May 07; 13(1). PMID: 35523809