Journal Article
. 2000 Dec;92(24).
doi: 10.1093/jnci/92.24.2029.

Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors

T L Chenevert 1 L D Stegman  J M Taylor  P L Robertson  H S Greenberg  A Rehemtulla  B D Ross  
  • PMID: 11121466
  •     249 citations


Background: A surrogate marker for treatment response that can be observed earlier than comparison of sequential magnetic resonance imaging (MRI) scans, which depends on relatively slow changes in tumor volume, may improve survival of brain tumor patients by providing more time for secondary therapeutic interventions. Previous studies in animals with the use of diffusion MRI revealed rapid changes in tumor water diffusion values after successful therapeutic intervention.

Methods: The present study examined the sensitivity of diffusion MRI measurements in orthotopic rat brain tumors derived from implanted rat 9L glioma cells. The effectiveness of therapy for individual brain cancer patients was evaluated by measuring changes in tumor volume on neuroimaging studies conducted 6--8 weeks after the conclusion of a treatment cycle.

Results: Diffusion MRI could detect water diffusion changes in orthotopic 9L gliomas after doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU or carmustine) that resulted in as little as 0.2 log cell kill, a measure of tumor cell death. Mean apparent diffusion coefficients in tumors were found to be correlated with and highly sensitive to changes in tumor cellularity (r =.78; two-sided P =.041). The feasibility of serial diffusion MRI in the clinical management of primary brain tumor patients was also demonstrated. Increased diffusion values could be detected in human brain tumors shortly after treatment initiation. The magnitude of the diffusion changes corresponded with clinical outcome.

Conclusions: These results suggest that diffusion MRI will provide an early surrogate marker for quantification of treatment response in patients with brain tumors.

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Risto A Kauppinen, Andrew C Peet.
Cancer Biol Ther, 2011 Oct 19; 12(8). PMID: 22004946    Free PMC article.
Incorporation of diffusion-weighted magnetic resonance imaging data into a simple mathematical model of tumor growth.
N C Atuegwu, D C Colvin, +3 authors, T E Yankeelov.
Phys Med Biol, 2011 Dec 14; 57(1). PMID: 22156038    Free PMC article.
Statistical power in quantitative diffusion MRI of tumor response: strategies for future studies.
Ted K Yanagihara, Benjamin Kennedy, Krishna Surapaneni, Jeffrey N Bruce.
Acad Radiol, 2011 Dec 20; 19(3). PMID: 22177972    Free PMC article.
Dynamic contrast-enhanced magnetic resonance imaging as a prognostic factor in predicting event-free and overall survival in pediatric patients with osteosarcoma.
Junyu Guo, Wilburn E Reddick, +10 authors, Najat C Daw.
Cancer, 2011 Dec 20; 118(15). PMID: 22180392    Free PMC article.
DCE and DW-MRI monitoring of vascular disruption following VEGF-Trap treatment of a rat glioma model.
Benjamin A Hoff, Mahaveer S Bhojani, +8 authors, Craig J Galbán.
NMR Biomed, 2011 Dec 23; 25(7). PMID: 22190279    Free PMC article.
Correlation of Gleason scores with diffusion-weighted imaging findings of prostate cancer.
Rajakumar Nagarajan, Daniel Margolis, +4 authors, M Albert Thomas.
Adv Urol, 2012 Jan 05; 2012. PMID: 22216026    Free PMC article.
Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.
Matthew J Wieduwilt, Francisco Valles, +9 authors, James L Rubenstein.
Clin Cancer Res, 2012 Jan 10; 18(4). PMID: 22228634    Free PMC article.
Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma.
Benjamin M Ellingson, Timothy F Cloughesy, +9 authors, Whitney B Pope.
Neuro Oncol, 2012 Jan 25; 14(3). PMID: 22270220    Free PMC article.
Specific biomarkers of receptors, pathways of inhibition and targeted therapies: clinical applications.
Y Waerzeggers, R T Ullrich, +6 authors, A H Jacobs.
Br J Radiol, 2012 May 25; 84 Spec No 2. PMID: 22433828    Free PMC article.
Clinical applications of imaging biomarkers. Part 3. The neuro-oncologist's perspective.
A Shenoy.
Br J Radiol, 2012 May 25; 84 Spec No 2. PMID: 22433830    Free PMC article.
Diffusion-weighted imaging-based probabilistic segmentation of high- and low-proliferative areas in high-grade gliomas.
Dirk Simon, Klaus H Fritzsche, +4 authors, Bram Stieltjes.
Cancer Imaging, 2012 Apr 11; 12. PMID: 22487677    Free PMC article.
The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function.
L C J Baker, J K R Boult, +4 authors, S P Robinson.
Br J Cancer, 2012 Apr 14; 106(10). PMID: 22498643    Free PMC article.
DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma.
Stefanie Galbán, Benjamin Lemasson, +11 authors, Brian D Ross.
PLoS One, 2012 Apr 27; 7(4). PMID: 22536446    Free PMC article.
Predicting treatment efficacy via quantitative magnetic resonance imaging: a Bayesian joint model.
Jincao Wu, Timothy D Johnson, +5 authors, Brian D Ross.
J R Stat Soc Ser C Appl Stat, 2012 May 12; 61(1). PMID: 22577240    Free PMC article.
Task-based evaluation of segmentation algorithms for diffusion-weighted MRI without using a gold standard.
Abhinav K Jha, Matthew A Kupinski, +2 authors, Alison T Stopeck.
Phys Med Biol, 2012 Jun 21; 57(13). PMID: 22713231    Free PMC article.
Imaging-based tumor treatment response evaluation: review of conventional, new, and emerging concepts.
Hee Kang, Ho Yun Lee, Kyung Soo Lee, Jae-Hun Kim.
Korean J Radiol, 2012 Jul 11; 13(4). PMID: 22778559    Free PMC article.
Survival analysis for apparent diffusion coefficient measures in children with embryonal brain tumours.
Matthew Grech-Sollars, Dawn E Saunders, +2 authors, Chris A Clark.
Neuro Oncol, 2012 Sep 08; 14(10). PMID: 22954494    Free PMC article.
Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging.
Rachel Grossman, Betty Tyler, +5 authors, Jinyuan Zhou.
J Neurooncol, 2012 Sep 27; 110(3). PMID: 23011120    Free PMC article.
Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian endometrioid adenocarcinoma.
Hanxiao Wang, Stefanie Galbán, +7 authors, Alnawaz Rehemtulla.
Clin Cancer Res, 2012 Oct 26; 19(1). PMID: 23095324    Free PMC article.
Neuroendocrine liver metastasis treated by using intraarterial therapy: volumetric functional imaging biomarkers of early tumor response and survival.
Vivek Gowdra Halappa, Celia Pamela Corona-Villalobos, +9 authors, Ihab R Kamel.
Radiology, 2012 Nov 30; 266(2). PMID: 23192780    Free PMC article.
Quantitative probabilistic functional diffusion mapping in newly diagnosed glioblastoma treated with radiochemotherapy.
Benjamin M Ellingson, Timothy F Cloughesy, +3 authors, Whitney B Pope.
Neuro Oncol, 2013 Jan 01; 15(3). PMID: 23275575    Free PMC article.
Multimodality imaging of tumor and bone response in a mouse model of bony metastasis.
Benjamin A Hoff, Komal Chughtai, +5 authors, Craig J Galbán.
Transl Oncol, 2013 Jan 17; 5(6). PMID: 23323156    Free PMC article.
DW-MRI as a Predictive Biomarker of Radiosensitization of GBM through Targeted Inhibition of Checkpoint Kinases.
Terence M Williams, Stefanie Galbán, +8 authors, Brian D Ross.
Transl Oncol, 2013 Apr 02; 6(2). PMID: 23544166    Free PMC article.
Longitudinal restriction spectrum imaging is resistant to pseudoresponse in patients with high-grade gliomas treated with bevacizumab.
Pranay Kothari, Nathan S White, +7 authors, Anders M Dale.
AJNR Am J Neuroradiol, 2013 Apr 13; 34(9). PMID: 23578667    Free PMC article.
Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics.
Daniel Rodriguez Gutierrez, Muftah Manita, +3 authors, Dorothee P Auer.
Neuro Oncol, 2013 Apr 16; 15(8). PMID: 23585630    Free PMC article.
Parameterizing the Logistic Model of Tumor Growth by DW-MRI and DCE-MRI Data to Predict Treatment Response and Changes in Breast Cancer Cellularity during Neoadjuvant Chemotherapy.
Nkiruka C Atuegwu, Lori R Arlinghaus, +4 authors, Thomas E Yankeelov.
Transl Oncol, 2013 Jun 05; 6(3). PMID: 23730404    Free PMC article.
MRI-guided monitoring of thermal dose and targeted drug delivery for cancer therapy.
Ruchika Fernando, Jon Downs, Danny Maples, Ashish Ranjan.
Pharm Res, 2013 Jun 20; 30(11). PMID: 23780716
Analysis and correction of gradient nonlinearity bias in apparent diffusion coefficient measurements.
Dariya I Malyarenko, Brian D Ross, Thomas L Chenevert.
Magn Reson Med, 2013 Jun 25; 71(3). PMID: 23794533    Free PMC article.
Ultrasonic spectrum analysis for in vivo characterization of tumor microstructural changes in the evaluation of tumor response to chemotherapy using diagnostic ultrasound.
Chun-yi Lin, Long-hui Cao, +5 authors, Jian-hua Zhou.
BMC Cancer, 2013 Jun 27; 13. PMID: 23800247    Free PMC article.
Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T.
Madhava P Aryal, Tavarekere N Nagaraja, +6 authors, James R Ewing.
Magn Reson Med, 2013 Jul 24; 71(6). PMID: 23878070    Free PMC article.
Identification of early and distinct glioblastoma response patterns treated by boron neutron capture therapy not predicted by standard radiographic assessment using functional diffusion map.
Ryo Hiramatsu, Shinji Kawabata, +2 authors, Toshihiko Kuroiwa.
Radiat Oncol, 2013 Aug 07; 8(1). PMID: 23915330    Free PMC article.
Diffusion weighted magnetic resonance imaging of the breast: protocol optimization, interpretation, and clinical applications.
Savannah C Partridge, Elizabeth S McDonald.
Magn Reson Imaging Clin N Am, 2013 Aug 10; 21(3). PMID: 23928248    Free PMC article.
Diffusion-weighted MRI as a biomarker for treatment response in glioma.
Kathleen M Schmainda.
CNS Oncol, 2013 Aug 13; 1(2). PMID: 23936625    Free PMC article.
Optimal pharmacotherapeutic management of hormone-sensitive metastatic prostate cancer.
Ajjai Alva, Maha Hussain.
Drugs, 2013 Aug 21; 73(14). PMID: 23959841
Diffusion-weighted magnetic resonance imaging for predicting the response of rectal cancer to neoadjuvant concurrent chemoradiation.
Gang Cai, Ye Xu, +5 authors, Zhen Zhang.
World J Gastroenterol, 2013 Sep 12; 19(33). PMID: 24023496    Free PMC article.
The comprehensive neuro-oncology data repository (CONDR): a research infrastructure to develop and validate imaging biomarkers.
Sarah Jost Fouke, Tammie L Benzinger, +8 authors, Daniel S Marcus.
Neurosurgery, 2013 Oct 04; 74(1). PMID: 24089052    Free PMC article.
Diffusion-Weighted MRI as a Biomarker of Tumor Radiation Treatment Response Heterogeneity: A Comparative Study of Whole-Volume Histogram Analysis versus Voxel-Based Functional Diffusion Map Analysis.
Benjamin Lemasson, Craig J Galbán, +8 authors, Brian D Ross.
Transl Oncol, 2013 Oct 24; 6(5). PMID: 24151536    Free PMC article.
The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.
Lihua Chen, Min Liu, +5 authors, Jian Wang.
PLoS One, 2013 Nov 19; 8(11). PMID: 24244402    Free PMC article.
Highly Cited. Review.
Nonlinear distortion correction of diffusion MR images improves quantitative DTI measurements in glioblastoma.
Davis C Woodworth, Whitney B Pope, +5 authors, Benjamin M Ellingson.
J Neurooncol, 2013 Dec 10; 116(3). PMID: 24318915    Free PMC article.
Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model.
Xiaohua Hong, Li Liu, +10 authors, Jinyuan Zhou.
Neuro Oncol, 2013 Dec 25; 16(6). PMID: 24366911    Free PMC article.
High-field small animal magnetic resonance oncology studies.
Louisa Bokacheva, Ellen Ackerstaff, +2 authors, Jason A Koutcher.
Phys Med Biol, 2014 Jan 01; 59(2). PMID: 24374985    Free PMC article.
Non-Gaussian water diffusion in aging white matter.
Jean-Philippe Coutu, J Jean Chen, H Diana Rosas, David H Salat.
Neurobiol Aging, 2014 Jan 01; 35(6). PMID: 24378085    Free PMC article.
Short-interval estimation of proliferation rate using serial diffusion MRI predicts progression-free survival in newly diagnosed glioblastoma treated with radiochemotherapy.
Taryar M Zaw, Whitney B Pope, +3 authors, Benjamin M Ellingson.
J Neurooncol, 2014 Jan 08; 116(3). PMID: 24395348    Free PMC article.
Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy.
Masamitsu Hatakenaka, Katsumasa Nakamura, +8 authors, Hiroshi Honda.
Jpn J Radiol, 2014 Jan 11; 32(2). PMID: 24408077
Imaging biomarkers for antiangiogenic therapy in malignant gliomas.
Kevin Leu, Whitney B Pope, +5 authors, Benjamin M Ellingson.
CNS Oncol, 2014 Feb 27; 2(1). PMID: 24570837    Free PMC article.
Repeatability of quantitative metrics derived from MR diffusion tractography in paediatric patients with epilepsy.
M J Paldino, K Hedges, K M Rodrigues, D P Barboriak.
Br J Radiol, 2014 Apr 12; 87(1037). PMID: 24720623    Free PMC article.
Lower apparent diffusion coefficients indicate distinct prognosis in low-grade and high-grade glioma.
Yong Cui, Li Ma, +3 authors, Song Lin.
J Neurooncol, 2014 May 31; 119(2). PMID: 24874469
Imaging mimics of primary malignant tumors of the central nervous system (CNS).
Mark Daniel Anderson, Rivka R Colen, Ivo W Tremont-Lukats.
Curr Oncol Rep, 2014 Jun 15; 16(8). PMID: 24927848
Clinical applications for diffusion magnetic resonance imaging in radiotherapy.
Christina Tsien, Yue Cao, Thomas Chenevert.
Semin Radiat Oncol, 2014 Jun 17; 24(3). PMID: 24931097    Free PMC article.
Precise ex vivo histological validation of heightened cellularity and diffusion-restricted necrosis in regions of dark apparent diffusion coefficient in 7 cases of high-grade glioma.
Peter S LaViolette, Nikolai J Mickevicius, +6 authors, Kathleen M Schmainda.
Neuro Oncol, 2014 Jul 26; 16(12). PMID: 25059209    Free PMC article.
Nitroxoline induces apoptosis and slows glioma growth in vivo.
Jelena Lazovic, Lea Guo, +6 authors, Whitney B Pope.
Neuro Oncol, 2014 Jul 31; 17(1). PMID: 25074541    Free PMC article.
Advanced magnetic resonance imaging of the physical processes in human glioblastoma.
Jayashree Kalpathy-Cramer, Elizabeth R Gerstner, +2 authors, Bruce Rosen.
Cancer Res, 2014 Sep 04; 74(17). PMID: 25183787    Free PMC article.
Advanced magnetic resonance imaging methods for planning and monitoring radiation therapy in patients with high-grade glioma.
Janine M Lupo, Sarah J Nelson.
Semin Radiat Oncol, 2014 Sep 16; 24(4). PMID: 25219809    Free PMC article.
Correlation of ADC value with pathologic indexes in colorectal tumor homografts in Balb/c mouse.
Xiaojun Li, Hongnan Jiang, Jinliang Niu, Ying Zheng.
Chin J Cancer Res, 2014 Sep 19; 26(4). PMID: 25232218    Free PMC article.
A Maximum-Likelihood Approach for ADC Estimation of Lesions in Visceral Organs.
Abhinav K Jha, Jeffrey J Rodríguez.
Proc IEEE Southwest Symp Image Anal Interpret, 2012 Jan 01; 2012. PMID: 25242901    Free PMC article.
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma.
Cecilie Brekke Rygh, Jian Wang, +9 authors, Martha Chekenya.
PLoS One, 2014 Oct 01; 9(9). PMID: 25268630    Free PMC article.
Emerging techniques and technologies in brain tumor imaging.
Benjamin M Ellingson, Martin Bendszus, A Gregory Sorensen, Whitney B Pope.
Neuro Oncol, 2014 Oct 15; 16 Suppl 7. PMID: 25313234    Free PMC article.
Report of the Jumpstarting Brain Tumor Drug Development Coalition and FDA clinical trials neuroimaging endpoint workshop (January 30, 2014, Bethesda MD).
Patrick Y Wen, Timothy F Cloughesy, +12 authors, Wai-Kwan Alfred Yung.
Neuro Oncol, 2014 Oct 15; 16 Suppl 7. PMID: 25313237    Free PMC article.
Independent contribution of individual white matter pathways to language function in pediatric epilepsy patients.
Michael J Paldino, Kara Hedges, Wei Zhang.
Neuroimage Clin, 2014 Nov 08; 6. PMID: 25379446    Free PMC article.
Radiogenomics and imaging phenotypes in glioblastoma: novel observations and correlation with molecular characteristics.
Benjamin M Ellingson.
Curr Neurol Neurosci Rep, 2014 Nov 21; 15(1). PMID: 25410316
Relationship Between [18F]FDOPA PET Uptake, Apparent Diffusion Coefficient (ADC), and Proliferation Rate in Recurrent Malignant Gliomas.
Elena Karavaeva, Robert J Harris, +10 authors, Benjamin M Ellingson.
Mol Imaging Biol, 2014 Dec 04; 17(3). PMID: 25465392
Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging.
Sumitaka Hasegawa, Yukie Morokoshi, +5 authors, Tsuneo Saga.
Mol Oncol, 2014 Dec 17; 9(3). PMID: 25510653    Free PMC article.
Practical estimate of gradient nonlinearity for implementation of apparent diffusion coefficient bias correction.
Dariya I Malkyarenko, Thomas L Chenevert.
J Magn Reson Imaging, 2015 Feb 11; 40(6). PMID: 25667948    Free PMC article.
sfDM: Open-Source Software for Temporal Analysis and Visualization of Brain Tumor Diffusion MR Using Serial Functional Diffusion Mapping.
Rafael Ceschin, Ashok Panigrahy, Vanathi Gopalakrishnan.
Cancer Inform, 2015 Feb 13; 14(Suppl 2). PMID: 25673970    Free PMC article.
Pitfalls in the neuroimaging of glioblastoma in the era of antiangiogenic and immuno/targeted therapy - detecting illusive disease, defining response.
Raymond Y Huang, Martha R Neagu, David A Reardon, Patrick Y Wen.
Front Neurol, 2015 Mar 11; 6. PMID: 25755649    Free PMC article.
Highly Cited. Review.
Between-Scanner and Between-Visit Variation in Normal White Matter Apparent Diffusion Coefficient Values in the Setting of a Multi-Center Clinical Trial.
J Huo, J Alger, +4 authors, J Goldin.
Clin Neuroradiol, 2015 Mar 21; 26(4). PMID: 25791203
Multi-site clinical evaluation of DW-MRI as a treatment response metric for breast cancer patients undergoing neoadjuvant chemotherapy.
Craig J Galbán, Bing Ma, +12 authors, Brian D Ross.
PLoS One, 2015 Mar 31; 10(3). PMID: 25816249    Free PMC article.
OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model.
Patricia Coutinho de Souza, Krithika Balasubramanian, +9 authors, Rheal A Towner.
J Magn Reson Imaging, 2015 Apr 30; 42(6). PMID: 25920494    Free PMC article.
Whole body diffusion weighted MRI--a new view of myeloma.
Christina Messiou, Martin Kaiser.
Br J Haematol, 2015 May 28; 171(1). PMID: 26013304    Free PMC article.
Tract-based analysis of white matter degeneration in Alzheimer's disease.
S-H Lee, J-P Coutu, +4 authors, Alzheimer’s disease Neuroimaging Initiative (ADNI).
Neuroscience, 2015 Jun 01; 301. PMID: 26026680    Free PMC article.
Multiparametric and Multimodality Functional Radiological Imaging for Breast Cancer Diagnosis and Early Treatment Response Assessment.
Michael A Jacobs, Antonio C Wolff, +5 authors, Richard Wahl.
J Natl Cancer Inst Monogr, 2015 Jun 13; 2015(51). PMID: 26063885    Free PMC article.
Hypercellularity Components of Glioblastoma Identified by High b-Value Diffusion-Weighted Imaging.
Priyanka P Pramanik, Hemant A Parmar, +5 authors, Yue Cao.
Int J Radiat Oncol Biol Phys, 2015 Jun 25; 92(4). PMID: 26104935    Free PMC article.
Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.
Patricia Coutinho de Souza, Samantha Mallory, +5 authors, Rheal A Towner.
PLoS One, 2015 Aug 08; 10(8). PMID: 26248280    Free PMC article.
Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials.
Benjamin M Ellingson, Martin Bendszus, +26 authors, Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee.
Neuro Oncol, 2015 Aug 08; 17(9). PMID: 26250565    Free PMC article.
Highly Cited. Review.
Parametric Response Mapping of Apparent Diffusion Coefficient as an Imaging Biomarker to Distinguish Pseudoprogression from True Tumor Progression in Peptide-Based Vaccine Therapy for Pediatric Diffuse Intrinsic Pontine Glioma.
R Ceschin, B F Kurland, +5 authors, A Panigrahy.
AJNR Am J Neuroradiol, 2015 Sep 05; 36(11). PMID: 26338910    Free PMC article.
Quantitative Evaluation of Diffusion and Dynamic Contrast-Enhanced MR in Tumor Parenchyma and Peritumoral Area for Distinction of Brain Tumors.
Jing Zhao, Zhi-yun Yang, +2 authors, Jian-ping Chu.
PLoS One, 2015 Sep 19; 10(9). PMID: 26384329    Free PMC article.
Increased tumour ADC value during chemotherapy predicts improved survival in unresectable pancreatic cancer.
Hideyuki Nishiofuku, Toshihiro Tanaka, +4 authors, Kimihiko Kichikawa.
Eur Radiol, 2015 Sep 20; 26(6). PMID: 26385808    Free PMC article.
Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium.
Tina Young Poussaint, Sridhar Vajapeyam, +6 authors, Maryam Fouladi.
Neuro Oncol, 2015 Oct 22; 18(5). PMID: 26487690    Free PMC article.
Assessing and monitoring intratumor heterogeneity in glioblastoma: how far has multimodal imaging come?
Natalie R Boonzaier, Sara G M Piccirillo, Colin Watts, Stephen J Price.
CNS Oncol, 2015 Oct 27; 4(6). PMID: 26497327    Free PMC article.
Development of a Multiparametric Voxel-Based Magnetic Resonance Imaging Biomarker for Early Cancer Therapeutic Response Assessment.
Craig J Galbán, Benjamin Lemasson, +5 authors, Brian D Ross.
Tomography, 2015 Nov 17; 1(1). PMID: 26568982    Free PMC article.
Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer.
Hiroshi Doi, Naohito Beppu, +5 authors, Shozo Hirota.
Mol Clin Oncol, 2015 Dec 02; 3(5). PMID: 26623064    Free PMC article.
Diffusion MR Characteristics Following Concurrent Radiochemotherapy Predicts Progression-Free and Overall Survival in Newly Diagnosed Glioblastoma.
Warren Chang, Whitney B Pope, +7 authors, Benjamin M Ellingson.
Tomography, 2016 Jan 08; 1(1). PMID: 26740971    Free PMC article.
A maximum-likelihood method to estimate a single ADC value of lesions using diffusion MRI.
Abhinav K Jha, Jeffrey J Rodríguez, Alison T Stopeck.
Magn Reson Med, 2016 Jan 09; 76(6). PMID: 26743234    Free PMC article.
Multiparametric MR imaging of tumor response to intraarterial chemotherapy in orthotopic xenograft models of human metastatic brain tumor.
Byungjun Kim, Keonha Kim, +4 authors, Hongsik Byun.
J Neurooncol, 2016 Jan 10; 127(2). PMID: 26746691
Diffusion MRI in early cancer therapeutic response assessment.
C J Galbán, B A Hoff, T L Chenevert, B D Ross.
NMR Biomed, 2016 Jan 17; 30(3). PMID: 26773848    Free PMC article.
Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model.
Benjamin Lemasson, Hanxiao Wang, +9 authors, Brian D Ross.
Neoplasia, 2016 Mar 05; 18(2). PMID: 26936394    Free PMC article.
Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors.
Björn Lampinen, Filip Szczepankiewicz, +5 authors, Markus Nilsson.
Magn Reson Med, 2016 Mar 13; 77(3). PMID: 26968557    Free PMC article.
Multivariate statistical analysis of diffusion imaging parameters using partial least squares: Application to white matter variations in Alzheimer's disease.
Ender Konukoglu, Jean-Philippe Coutu, +2 authors, Alzheimer's Disease Neuroimaging Initiative (ADNI).
Neuroimage, 2016 Apr 23; 134. PMID: 27103138    Free PMC article.
Restriction spectrum imaging predicts response to bevacizumab in patients with high-grade glioma.
Carrie R McDonald, Rachel L Delfanti, +11 authors, Nikdokht Farid.
Neuro Oncol, 2016 Apr 24; 18(11). PMID: 27106406    Free PMC article.
Diffusion-weighted magnetic resonance imaging predicts survival in patients with liver-predominant metastatic colorectal cancer shortly after selective internal radiation therapy.
Frederic Carsten Schmeel, Birgit Simon, +6 authors, Dariusch Reza Hadizadeh.
Eur Radiol, 2016 Jun 09; 27(3). PMID: 27271923
Early Detection of Treatment-Induced Mitotic Arrest Using Temporal Diffusion Magnetic Resonance Spectroscopy.
Xiaoyu Jiang, Hua Li, +4 authors, John C Gore.
Neoplasia, 2016 Jun 14; 18(6). PMID: 27292027    Free PMC article.
Integrative analysis of diffusion-weighted MRI and genomic data to inform treatment of glioblastoma.
Guido H Jajamovich, Chandni R Valiathan, Razvan Cristescu, Sangeetha Somayajula.
J Neurooncol, 2016 Jul 10; 129(2). PMID: 27393347
The link between diffusion MRI and tumor heterogeneity: Mapping cell eccentricity and density by diffusional variance decomposition (DIVIDE).
Filip Szczepankiewicz, Danielle van Westen, +5 authors, Markus Nilsson.
Neuroimage, 2016 Jul 28; 142. PMID: 27450666    Free PMC article.
Highly Cited.
Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging.
Bruce J Tromberg, Zheng Zhang, +20 authors, ACRIN 6691 investigators.
Cancer Res, 2016 Aug 17; 76(20). PMID: 27527559    Free PMC article.
Early Detection of Malignant Transformation in Resected WHO II Low-Grade Glioma Using Diffusion Tensor-Derived Quantitative Measures.
Martin T Freitag, Klaus H Maier-Hein, +8 authors, Bram Stieltjes.
PLoS One, 2016 Oct 16; 11(10). PMID: 27741525    Free PMC article.
Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience.
David Aramburu Núñez, Antonio Lopez Medina, +8 authors, Victor M Muñoz.
World J Radiol, 2017 Feb 02; 9(1). PMID: 28144403    Free PMC article.
The distribution of the apparent diffusion coefficient as an indicator of the response to chemotherapeutics in ovarian tumour xenografts.
Monique C Tourell, Ali Shokoohmand, +4 authors, Konstantin I Momot.
Sci Rep, 2017 Feb 22; 7. PMID: 28220831    Free PMC article.
Proton MR Spectroscopy and Diffusion MR Imaging Monitoring to Predict Tumor Response to Interstitial Photodynamic Therapy for Glioblastoma.
Magali Toussaint, Sophie Pinel, +12 authors, Muriel Barberi-Heyob.
Theranostics, 2017 Mar 04; 7(2). PMID: 28255341    Free PMC article.
Semiautomated Workflow for Clinically Streamlined Glioma Parametric Response Mapping.
Lauren Keith, Brian D Ross, +6 authors, Benjamin A Hoff.
Tomography, 2017 Mar 14; 2(4). PMID: 28286871    Free PMC article.
Correlation of 18F-FDG PET and MRI Apparent Diffusion Coefficient Histogram Metrics with Survival in Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium.
Katherine A Zukotynski, Sridhar Vajapeyam, +6 authors, Tina Young Poussaint.
J Nucl Med, 2017 Apr 01; 58(8). PMID: 28360212    Free PMC article.
The value of MRI in evaluating the efficacy and complications with the treatment of intra-arterial chemotherapy for retinoblastoma.
Shuxian Chen, Xunda Ji, +5 authors, Yuhua Li.
Oncotarget, 2017 Apr 19; 8(24). PMID: 28415600    Free PMC article.
Value of Minimum Apparent Diffusion Coefficient on Magnetic Resonance Imaging as a Biomarker for Predicting Progression of Disease Following Surgery and Radiotherapy in Glial Tumors from a Tertiary Care Center in Northern India.
Pramod Kumar Gupta, Rishi Awasthi, +4 authors, Shaleen Kumar.
J Neurosci Rural Pract, 2017 May 10; 8(2). PMID: 28479790    Free PMC article.
Assessment of stereotactic radiosurgery treatment response for brain metastases using MRI based diffusion index.
Zengai Chen, Jinyan Zu, +3 authors, Jianrong Xu.
Eur J Radiol Open, 2017 Jul 21; 4. PMID: 28725661    Free PMC article.
Diffusion-weighted MR imaging in prediction of response to neoadjuvant chemotherapy in patients with breast cancer.
Xue-Ying Hu, Ying Li, +3 authors, Dan-Ke Su.
Oncotarget, 2017 Nov 08; 8(45). PMID: 29108344    Free PMC article.
Tumor image signatures and habitats: a processing pipeline of multimodality metabolic and physiological images.
Daekeun You, Michelle M Kim, +4 authors, Yue Cao.
J Med Imaging (Bellingham), 2017 Nov 29; 5(1). PMID: 29181433    Free PMC article.
Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice.
S C Thust, S Heiland, +11 authors, M Smits.
Eur Radiol, 2018 Mar 15; 28(8). PMID: 29536240    Free PMC article.
Multiparametric Whole-body MRI with Diffusion-weighted Imaging and ADC Mapping for the Identification of Visceral and Osseous Metastases From Solid Tumors.
Michael A Jacobs, Katarzyna J Macura, +7 authors, Li Pan.
Acad Radiol, 2018 Apr 09; 25(11). PMID: 29627288    Free PMC article.
Texture analysis of diffusion weighted imaging for the evaluation of glioma heterogeneity based on different regions of interest.
Shan Wang, Meng Meng, +5 authors, Kai Xu.
Oncol Lett, 2018 May 08; 15(5). PMID: 29731887    Free PMC article.
Diffusion-weighted MRI Findings Predict Pathologic Response in Neoadjuvant Treatment of Breast Cancer: The ACRIN 6698 Multicenter Trial.
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Developing a Pipeline for Multiparametric MRI-Guided Radiation Therapy: Initial Results from a Phase II Clinical Trial in Newly Diagnosed Glioblastoma.
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Noninvasive Quantification of Cell Density in Three-Dimensional Gels by MRI.
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