Journal Article
. 2000 Dec; 166(1):678-89.
doi: 10.4049/jimmunol.166.1.678.

Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer

B Almand 1 J I Clark  E Nikitina  J van Beynen  N R English  S C Knight  D P Carbone  D I Gabrilovich  
Affiliations
  • PMID: 11123353
  •     511 citations

Abstract

Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an important mechanism of tumor escape from immune system control. Previously, we have demonstrated that the number and function of DC were dramatically reduced in cancer patients. This effect was closely associated with accumulation of immature cells (ImC) in peripheral blood. In this study, we investigated the nature and functional role of those ImC. Using flow cytometry, electron microscopy, colony formation assays, and cell differentiation in the presence of different cell growth factors, we have determined that the population of ImC is composed of a small percentage (<2%) of hemopoietic progenitor cells, with all other cells being represented by MHC class I-positive myeloid cells. About one-third of ImC were immature macrophages and DC, and the remaining cells were immature myeloid cells at earlier stages of differentiation. These cells were differentiated into mature DC in the presence of 1 microM all-trans-retinoic acid. Removal of ImC from DC fractions completely restored the ability of the DC to stimulate allogeneic T cells. In two different experimental systems ImC inhibited Ag-specific T cell responses. Thus, immature myeloid cells generated in large numbers in cancer patients are able to directly inhibit Ag-specific T cell responses. This may represent a new mechanism of immune suppression in cancer and may suggest a new approach to cancer treatment.

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Nathan R Miselis, Bonnie W Lau, Zhijin Wu, Agnes B Kane.
Cancer Microenviron, 2010 Jan 01; 4(1). PMID: 21505561    Free PMC article.
Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12.
Mariana Malvicini, Mariana Ingolotti, +10 authors, Guillermo Mazzolini.
Mol Oncol, 2011 Apr 26; 5(3). PMID: 21515097    Free PMC article.
Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis.
Angela M Boutté, David B Friedman, +3 authors, P Charles Lin.
FASEB J, 2011 Apr 27; 25(8). PMID: 21518852    Free PMC article.
How tumors might withstand γδ T-cell attack.
Aude-Hélène Capietto, Ludovic Martinet, Jean-Jacques Fournié.
Cell Mol Life Sci, 2011 May 07; 68(14). PMID: 21547501
Review.
Tumor-infiltrating programmed death receptor-1+ dendritic cells mediate immune suppression in ovarian cancer.
James Krempski, Lavakumar Karyampudi, +6 authors, Keith L Knutson.
J Immunol, 2011 May 10; 186(12). PMID: 21551365    Free PMC article.
Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth.
Upendra K Kar, Minu K Srivastava, +6 authors, Sherven Sharma.
PLoS One, 2011 May 12; 6(5). PMID: 21559281    Free PMC article.
Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity.
Sheng Xia, Haibo Sha, +3 authors, Ling Qi.
J Biol Chem, 2011 May 20; 286(26). PMID: 21592961    Free PMC article.
Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer.
P Goedegebuure, J B Mitchem, +6 authors, D C Linehan.
Curr Cancer Drug Targets, 2011 May 24; 11(6). PMID: 21599634    Free PMC article.
Review.
Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4⁺ T cells from patients with GI malignancy.
Bethany L Mundy-Bosse, Gregory S Young, +6 authors, Gregory B Lesinski.
Cancer Immunol Immunother, 2011 May 24; 60(9). PMID: 21604071    Free PMC article.
Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma.
Baisakhi Raychaudhuri, Patricia Rayman, +6 authors, James Finke.
Neuro Oncol, 2011 Jun 04; 13(6). PMID: 21636707    Free PMC article.
Highly Cited.
Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression?
Marco Tucci, Stefania Stucci, +2 authors, Franco Silvestris.
Oncologist, 2011 Jun 11; 16(7). PMID: 21659611    Free PMC article.
Review.
Density of Gr1-positive myeloid precursor cells, p-STAT3 expression and gene expression pattern in canine mammary cancer metastasis.
Magdalena Król, Karol M Pawłowski, +4 authors, Tomasz Motyl.
Vet Res Commun, 2011 Jun 30; 35(7). PMID: 21713436    Free PMC article.
Dendritic cells in cancer immunotherapy: vaccines or autologous transplants?
Pawel Kalinski, Howard Edington, +4 authors, David L Bartlett.
Immunol Res, 2011 Jul 01; 50(2-3). PMID: 21717071    Free PMC article.
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells.
Samantha Solito, Erika Falisi, +11 authors, Susanna Mandruzzato.
Blood, 2011 Jul 08; 118(8). PMID: 21734236    Free PMC article.
Highly Cited.
Plasticity of Ly-6C(hi) myeloid cells in T cell regulation.
Bing Zhu, Jennifer K Kennedy, +6 authors, Samia J Khoury.
J Immunol, 2011 Aug 10; 187(5). PMID: 21824867    Free PMC article.
Characterization of the MDSC proteome associated with metastatic murine mammary tumors using label-free mass spectrometry and shotgun proteomics.
Angela M Boutté, W Hayes McDonald, +2 authors, P Charles Lin.
PLoS One, 2011 Aug 20; 6(8). PMID: 21853032    Free PMC article.
Origin and Functions of Tumor-Associated Myeloid Cells (TAMCs).
Antonio Sica, Chiara Porta, +5 authors, Elena Riboldi.
Cancer Microenviron, 2011 Sep 29; 5(2). PMID: 21948460    Free PMC article.
Bone marrow and the control of immunity.
Ende Zhao, Huanbin Xu, +5 authors, Weiping Zou.
Cell Mol Immunol, 2011 Oct 25; 9(1). PMID: 22020068    Free PMC article.
Review.
IL-10 contributes to the suppressive function of tumour-associated myeloid cells and enhances myeloid cell accumulation in tumours.
L-X Wang, F Talebian, +3 authors, X-F Bai.
Scand J Immunol, 2011 Nov 05; 75(3). PMID: 22050574    Free PMC article.
Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis.
Ilan Vaknin, Gilad Kunis, +7 authors, Michal Schwartz.
PLoS One, 2011 Nov 11; 6(11). PMID: 22073221    Free PMC article.
CD15+/CD16low human granulocytes from terminal cancer patients: granulocytic myeloid-derived suppressor cells that have suppressive function.
Jahyang Choi, Beomseok Suh, +4 authors, Dae Seog Heo.
Tumour Biol, 2011 Nov 15; 33(1). PMID: 22081309
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524    Free PMC article.
Review.
A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.
Janesh Pillay, Vera M Kamp, +7 authors, Leo Koenderman.
J Clin Invest, 2011 Dec 14; 122(1). PMID: 22156198    Free PMC article.
Highly Cited.
Immune microenvironments in solid tumors: new targets for therapy.
Stephen L Shiao, A Preethi Ganesan, Hope S Rugo, Lisa M Coussens.
Genes Dev, 2011 Dec 23; 25(24). PMID: 22190457    Free PMC article.
Highly Cited. Review.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Oana Draghiciu, Hans W Nijman, Toos Daemen.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971    Free PMC article.
Review.
Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth.
Matthew R Porembka, Jonathan B Mitchem, +6 authors, Peter Goedegebuure.
Cancer Immunol Immunother, 2012 Jan 05; 61(9). PMID: 22215137    Free PMC article.
Highly Cited.
Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner.
Tillmann Michels, Galina V Shurin, +3 authors, Michael R Shurin.
J Immunotoxicol, 2012 Jan 31; 9(3). PMID: 22283566    Free PMC article.
S100A9 a new marker for monocytic human myeloid-derived suppressor cells.
Fei Zhao, Bastian Hoechst, +5 authors, Firouzeh Korangy.
Immunology, 2012 Feb 07; 136(2). PMID: 22304731    Free PMC article.
Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells.
Srinivas Nagaraj, Dmitry I Gabrilovich.
Semin Cancer Biol, 2012 Feb 09; 22(4). PMID: 22313876    Free PMC article.
Review.
Respiratory Homeostasis and Exploitation of the Immune System for Lung Cancer Vaccines.
Adam Yagui-Beltrán, Lisa M Coussens, David M Jablons.
US Oncol, 2009 Jan 01; 58(1). PMID: 22368692    Free PMC article.
Myeloid suppressor cells and immune modulation in lung cancer.
Minu K Srivastava, Åsa Andersson, +4 authors, Sherven Sharma.
Immunotherapy, 2012 Mar 10; 4(3). PMID: 22401635    Free PMC article.
Review.
Langerhans cells from human cutaneous squamous cell carcinoma induce strong type 1 immunity.
Hideki Fujita, Mayte Suárez-Fariñas, +6 authors, John A Carucci.
J Invest Dermatol, 2012 Mar 10; 132(6). PMID: 22402444    Free PMC article.
Pancreatic ductal adenocarcinoma: a review of immunologic aspects.
Megan B Wachsmann, Laurentiu M Pop, Ellen S Vitetta.
J Investig Med, 2012 Mar 13; 60(4). PMID: 22406516    Free PMC article.
Review.
Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1.
Rongze Lu, Maciej Kujawski, Hao Pan, John E Shively.
Cancer Res, 2012 Mar 13; 72(9). PMID: 22406619    Free PMC article.
Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy.
Courtney A Crane, Brian J Ahn, Seunggu J Han, Andrew T Parsa.
Neuro Oncol, 2012 Mar 13; 14(5). PMID: 22406925    Free PMC article.
Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.
Salvador J Diaz-Cano.
Int J Mol Sci, 2012 Mar 13; 13(2). PMID: 22408433    Free PMC article.
Review.
Identification of myeloid derived suppressor cells in dogs with naturally occurring cancer.
Michelle R Goulart, G Elizabeth Pluhar, John R Ohlfest.
PLoS One, 2012 Mar 20; 7(3). PMID: 22428007    Free PMC article.
Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response.
Laura Brudecki, Donald A Ferguson, Charles E McCall, Mohamed El Gazzar.
Infect Immun, 2012 Mar 28; 80(6). PMID: 22451518    Free PMC article.
Myeloid-derived suppressor cells participate in preventing graft rejection.
Yan Wang, Xiaodong Gu, Jianbin Xiang, Zongyou Chen.
Clin Dev Immunol, 2012 Apr 07; 2012. PMID: 22481970    Free PMC article.
Review.
Gr-1+CD11b+ cells are responsible for tumor promoting effect of TGF-β in breast cancer progression.
Zhaoyang Li, Yanli Pang, +5 authors, Li Yang.
Int J Cancer, 2012 Apr 11; 131(11). PMID: 22487809    Free PMC article.
Suppression of natural killer-cell and dendritic-cell apoptotic tumoricidal activity in patients with head and neck cancer.
Dejan Baskic, Lazar Vujanovic, +3 authors, Nikola L Vujanovic.
Head Neck, 2012 Apr 11; 35(3). PMID: 22488918    Free PMC article.
Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples.
Athanasios Kotsakis, Malgorzata Harasymczuk, +3 authors, Theresa L Whiteside.
J Immunol Methods, 2012 Apr 24; 381(1-2). PMID: 22522114    Free PMC article.
Phenotypic, morphological, and functional heterogeneity of splenic immature myeloid cells in the host response to tularemia.
John W Rasmussen, Jason W Tam, +5 authors, Adrianus W M van der Velden.
Infect Immun, 2012 Apr 25; 80(7). PMID: 22526678    Free PMC article.
Liposomal clodronate treatment for tumour macrophage depletion in dogs with soft-tissue sarcoma.
A M Guth, S D Hafeman, R E Elmslie, S W Dow.
Vet Comp Oncol, 2012 May 01; 11(4). PMID: 22540967    Free PMC article.
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide.
Mohamed L Salem, Amir A Al-Khami, +4 authors, David J Cole.
Cell Immunol, 2012 May 09; 276(1-2). PMID: 22560674    Free PMC article.
Tolerance-inducing strategies in islet transplantation.
Sumantha Bhatt, John J Fung, Lina Lu, Shiguang Qian.
Int J Endocrinol, 2012 Jun 08; 2012. PMID: 22675353    Free PMC article.
Exosome removal as a therapeutic adjuvant in cancer.
Annette M Marleau, Chien-Shing Chen, James A Joyce, Richard H Tullis.
J Transl Med, 2012 Jun 29; 10. PMID: 22738135    Free PMC article.
Highly Cited.
Increased frequency and clinical significance of myeloid-derived suppressor cells in human colorectal carcinoma.
Hong-Li Sun, Xin Zhou, +5 authors, Zong-Ning Miao.
World J Gastroenterol, 2012 Jul 12; 18(25). PMID: 22783056    Free PMC article.
Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance.
Nahzli Dilek, Romain Vuillefroy de Silly, Gilles Blancho, Bernard Vanhove.
Front Immunol, 2012 Jul 24; 3. PMID: 22822406    Free PMC article.
Myeloid cells in tumor inflammation.
Michael C Schmid, Judith A Varner.
Vasc Cell, 2012 Sep 04; 4(1). PMID: 22938502    Free PMC article.
Influence of human immune cells on cancer: studies at the University of Colorado.
Tullia C Bruno, Jena D French, +7 authors, Jill E Slansky.
Immunol Res, 2012 Sep 04; 55(1-3). PMID: 22941561    Free PMC article.
Review.
Protumor and antitumor functions of neutrophil granulocytes.
Sven Brandau, Claudia A Dumitru, Stephan Lang.
Semin Immunopathol, 2012 Sep 26; 35(2). PMID: 23007469
Review.
Myeloid-derived suppressor cells and anti-tumor T cells: a complex relationship.
Ngozi R Monu, Alan B Frey.
Immunol Invest, 2012 Sep 29; 41(6-7). PMID: 23017137    Free PMC article.
Review.
Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives.
Patrick Raber, Augusto C Ochoa, Paulo C Rodríguez.
Immunol Invest, 2012 Sep 29; 41(6-7). PMID: 23017138    Free PMC article.
Highly Cited. Review.
Myeloid-derived suppressor cells adhere to physiologic STAT3- vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape.
Peter A Cohen, Jennifer S Ko, +11 authors, James H Finke.
Immunol Invest, 2012 Sep 29; 41(6-7). PMID: 23017141    Free PMC article.
Review.
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.
Samuel Asfaha, Alexander N Dubeykovskiy, +11 authors, Timothy C Wang.
Gastroenterology, 2012 Oct 09; 144(1). PMID: 23041326    Free PMC article.
Human monocytes differentiate into dendritic cells subsets that induce anergic and regulatory T cells in sepsis.
Valérie Faivre, Anne Claire Lukaszewicz, +3 authors, Alain Haziot.
PLoS One, 2012 Oct 17; 7(10). PMID: 23071758    Free PMC article.
Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice.
Chi Ma, Tamar Kapanadze, +3 authors, Tim F Greten.
J Leukoc Biol, 2012 Oct 19; 92(6). PMID: 23077247    Free PMC article.
Correlation between circulating myeloid-derived suppressor cells and Th17 cells in esophageal cancer.
Zhi-Jun Jiao, Jing-Jing Gao, +5 authors, Hua-Xi Xu.
World J Gastroenterol, 2012 Oct 20; 18(38). PMID: 23082063    Free PMC article.
Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma.
Krithika N Kodumudi, Amy Weber, Amod A Sarnaik, Shari Pilon-Thomas.
J Immunol, 2012 Oct 27; 189(11). PMID: 23100512    Free PMC article.
Harnessing DNA-induced immune responses for improving cancer vaccines.
Andrés A Herrada, Nicole Rojas-Colonelli, +4 authors, Alvaro Lladser.
Hum Vaccin Immunother, 2012 Nov 01; 8(11). PMID: 23111166    Free PMC article.
Review.
Macrophage migration inhibitory factor promotes tumor growth and metastasis by inducing myeloid-derived suppressor cells in the tumor microenvironment.
Kendra D Simpson, Dennis J Templeton, Janet V Cross.
J Immunol, 2012 Nov 06; 189(12). PMID: 23125418    Free PMC article.
Highly Cited.
Dendritic cell-based vaccines: barriers and opportunities.
Jessica A Cintolo, Jashodeep Datta, Sarah J Mathew, Brian J Czerniecki.
Future Oncol, 2012 Nov 08; 8(10). PMID: 23130928    Free PMC article.
Review.
Depletion of phagocytic myeloid cells triggers spontaneous T cell- and NK cell-dependent antitumor activity.
Amanda M Guth, Scott D Hafeman, Steven W Dow.
Oncoimmunology, 2012 Dec 18; 1(8). PMID: 23243588    Free PMC article.
HLA-DR(hi) and CCR9 Define a Pro-Inflammatory Monocyte Subset in IBD.
Ludvig Linton, Mats Karlsson, +9 authors, Michael Eberhardson.
Clin Transl Gastroenterol, 2012 Dec 21; 3. PMID: 23254312    Free PMC article.
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?
V Kumar.
Purinergic Signal, 2012 Dec 29; 9(2). PMID: 23271562    Free PMC article.
Review.
Polysaccharide from Lentinus edodes inhibits the immunosuppressive function of myeloid-derived suppressor cells.
Hao Wu, Ning Tao, +8 authors, Zhihai Qin.
PLoS One, 2012 Dec 29; 7(12). PMID: 23272159    Free PMC article.
Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans.
Güllü Topal Görgün, Gregory Whitehill, +7 authors, Kenneth C Anderson.
Blood, 2013 Jan 17; 121(15). PMID: 23321256    Free PMC article.
Highly Cited.
Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast.
Hang Wang, Yi-Lin Chan, +9 authors, Chang-Jer Wu.
PLoS One, 2013 Jan 26; 8(1). PMID: 23349693    Free PMC article.
Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study.
Daniela Basso, Paola Fogar, +21 authors, Mario Plebani.
PLoS One, 2013 Jan 30; 8(1). PMID: 23359812    Free PMC article.
In vivo ablation of plasmacytoid dendritic cells inhibits autoimmunity through expansion of myeloid-derived suppressor cells.
Marianna Ioannou, Themis Alissafi, +2 authors, Panayotis Verginis.
J Immunol, 2013 Feb 06; 190(6). PMID: 23382560    Free PMC article.
Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia.
Lisa Christiansson, Stina Söderlund, +5 authors, Angelica S I Loskog.
PLoS One, 2013 Feb 06; 8(1). PMID: 23383287    Free PMC article.
Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences.
Janesh Pillay, Tamar Tak, Vera M Kamp, Leo Koenderman.
Cell Mol Life Sci, 2013 Feb 21; 70(20). PMID: 23423530    Free PMC article.
Highly Cited. Review.
Myeloid-derived suppressor cells regulate growth of multiple myeloma by inhibiting T cells in bone marrow.
Indu R Ramachandran, Anna Martner, +6 authors, Yulia Nefedova.
J Immunol, 2013 Mar 06; 190(7). PMID: 23460744    Free PMC article.
Highly Cited.
Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells.
Laura M Hix, John Karavitis, +3 authors, Ming Zhang.
J Biol Chem, 2013 Mar 15; 288(17). PMID: 23486482    Free PMC article.
Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer.
Cristina Iclozan, Scott Antonia, +2 authors, Dmitry Gabrilovich.
Cancer Immunol Immunother, 2013 Apr 17; 62(5). PMID: 23589106    Free PMC article.
Highly Cited.
Monitoring dendritic cell and cytokine biomarkers during remission prior to relapse in patients with FLT3-ITD acute myeloid leukemia.
Mareike Rickmann, Laura Macke, +7 authors, Renata Stripecke.
Ann Hematol, 2013 Apr 26; 92(8). PMID: 23616009    Free PMC article.
T-cell tolerance in cancer.
Roza Nurieva, Junmei Wang, Anupama Sahoo.
Immunotherapy, 2013 May 04; 5(5). PMID: 23638746    Free PMC article.
Review.
TGF-β signaling in myeloid cells is required for tumor metastasis.
Yanli Pang, Sudheer Kumar Gara, +7 authors, Li Yang.
Cancer Discov, 2013 May 11; 3(8). PMID: 23661553    Free PMC article.
Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model.
Yi-Rang Na, Yi-Na Yoon, Da-In Son, Seung-Hyeok Seok.
PLoS One, 2013 May 15; 8(5). PMID: 23667623    Free PMC article.
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion.
Markus Munder, Melanie Engelhardt, +13 authors, Michael Hundemer.
PLoS One, 2013 May 30; 8(5). PMID: 23717444    Free PMC article.
Myeloid derived suppressor cells: Targets for therapy.
Todd J Waldron, Jon G Quatromoni, +2 authors, Anil K Rustgi.
Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734336    Free PMC article.
Myeloid-derived suppressor cells as a novel target for the control of osteolytic bone disease.
Anandi Sawant, Selvarangan Ponnazhagan.
Oncoimmunology, 2013 Jun 14; 2(5). PMID: 23762794    Free PMC article.
The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.
Qing Chang, Eirini Bournazou, +23 authors, Jacqueline Bromberg.
Neoplasia, 2013 Jul 03; 15(7). PMID: 23814496    Free PMC article.
Highly Cited.
Myeloid-derived suppressor cells in breast cancer.
Joseph Markowitz, Robert Wesolowski, +2 authors, William E Carson.
Breast Cancer Res Treat, 2013 Jul 06; 140(1). PMID: 23828498    Free PMC article.
Review.
Tumor-altered dendritic cell function: implications for anti-tumor immunity.
Kristian M Hargadon.
Front Immunol, 2013 Jul 23; 4. PMID: 23874338    Free PMC article.
GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-α.
Gary Kohanbash, Kayla McKaveney, +6 authors, Hideho Okada.
Cancer Res, 2013 Sep 14; 73(21). PMID: 24030977    Free PMC article.
Highly Cited.
Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-met and STAT3.
B Linju Yen, Men-Luh Yen, +4 authors, Huey-Kang Sytwu.
Stem Cell Reports, 2013 Sep 21; 1(2). PMID: 24052949    Free PMC article.
STAT3 activation: A key factor in tumor immunoescape.
Cédric Rébé, Frédérique Végran, Hélène Berger, François Ghiringhelli.
JAKSTAT, 2013 Sep 24; 2(1). PMID: 24058791    Free PMC article.
Review.
History of myeloid-derived suppressor cells.
James E Talmadge, Dmitry I Gabrilovich.
Nat Rev Cancer, 2013 Sep 26; 13(10). PMID: 24060865    Free PMC article.
Highly Cited. Review.
Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients.
Kimberly R Jordan, Rodabe N Amaria, +6 authors, Martin D McCarter.
Cancer Immunol Immunother, 2013 Sep 28; 62(11). PMID: 24072401    Free PMC article.
A role for CCL2 in both tumor progression and immunosurveillance.
Ming Li, Deborah A Knight, +2 authors, Trina J Stewart.
Oncoimmunology, 2013 Sep 28; 2(7). PMID: 24073384    Free PMC article.
Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.
Aude-Hélène Capietto, Seokho Kim, +5 authors, Roberta Faccio.
J Exp Med, 2013 Oct 16; 210(11). PMID: 24127488    Free PMC article.
Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.
Dror Luger, Yu-An Yang, +6 authors, Lalage M Wakefield.
PLoS One, 2013 Oct 23; 8(10). PMID: 24146823    Free PMC article.
Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer.
Darya Alizadeh, Malika Trad, +5 authors, Nicolas Larmonier.
Cancer Res, 2013 Nov 08; 74(1). PMID: 24197130    Free PMC article.
Highly Cited.
Immunological off-target effects of standard treatments in gastrointestinal cancers.
A G Duffy, T F Greten.
Ann Oncol, 2013 Nov 10; 25(1). PMID: 24201974    Free PMC article.
Review.
Immune regulatory activity of vitamin d3 in head and neck cancer.
M Rita I Young, Terry A Day.
Cancers (Basel), 2013 Nov 10; 5(3). PMID: 24202334    Free PMC article.
Microenvironmental regulation of tumor progression and metastasis.
Daniela F Quail, Johanna A Joyce.
Nat Med, 2013 Nov 10; 19(11). PMID: 24202395    Free PMC article.
Highly Cited. Review.
Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly.
Paolo Serafini.
Immunol Res, 2013 Nov 10; 57(1-3). PMID: 24203443
Review.
Immune modulation by chemotherapy or immunotherapy to enhance cancer vaccines.
Genevieve M Weir, Robert S Liwski, Marc Mansour.
Cancers (Basel), 2011 Jan 01; 3(3). PMID: 24212948    Free PMC article.
Immunotherapy: shifting the balance of cell-mediated immunity and suppression in human prostate cancer.
Jo A Tucker, Caroline Jochems, +2 authors, Kwong Y Tsang.
Cancers (Basel), 2012 Jan 01; 4(4). PMID: 24213509    Free PMC article.
Lentiviral vector-based therapy in head and neck cancer (Review).
Deepak Upreti, Alok Pathak, Sam K P Kung.
Oncol Lett, 2013 Dec 19; 7(1). PMID: 24348811    Free PMC article.
Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression.
Ainhoa Arina, Karin Schreiber, +3 authors, Hans Schreiber.
J Immunol, 2013 Dec 25; 192(3). PMID: 24367029    Free PMC article.
The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells.
M R Moniri, L-J Dai, G L Warnock.
Cancer Gene Ther, 2014 Jan 05; 21(1). PMID: 24384772
Review.
Immunotherapy for solid tumors--a review for surgeons.
Abdul Saied, Venu G Pillarisetty, Steven C Katz.
J Surg Res, 2014 Feb 04; 187(2). PMID: 24485876    Free PMC article.
Review.
Myeloid-derived suppressor cells are associated with viral persistence and downregulation of TCR ζ chain expression on CD8(+) T cells in chronic hepatitis C patients.
Qing-Lei Zeng, Bin Yang, +6 authors, Fu-Sheng Wang.
Mol Cells, 2014 Feb 21; 37(1). PMID: 24552712    Free PMC article.
Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells.
Nicolas Espagnolle, Pauline Barron, +8 authors, Antoine Alam.
Cancers (Basel), 2014 Mar 05; 6(1). PMID: 24589997    Free PMC article.
Increased IL-17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers.
Takashi Yazawa, Masahiko Shibata, +12 authors, Seiichi Takenoshita.
Mol Clin Oncol, 2014 Mar 22; 1(4). PMID: 24649227    Free PMC article.
CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets.
Michelle K Gleason, Julie A Ross, +13 authors, Jeffrey S Miller.
Blood, 2014 Mar 22; 123(19). PMID: 24652987    Free PMC article.
Highly Cited.
Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells.
Mylène A Carrascal, Paulo F Severino, +9 authors, Paula A Videira.
Mol Oncol, 2014 Mar 25; 8(3). PMID: 24656965    Free PMC article.
Pten null prostate epithelium promotes localized myeloid-derived suppressor cell expansion and immune suppression during tumor initiation and progression.
Alejandro J Garcia, Marcus Ruscetti, +8 authors, Hong Wu.
Mol Cell Biol, 2014 Mar 26; 34(11). PMID: 24662052    Free PMC article.
A role for T-lymphocytes in human breast cancer and in canine mammary tumors.
Maria Isabel Carvalho, Isabel Pires, Justina Prada, Felisbina L Queiroga.
Biomed Res Int, 2014 Mar 29; 2014. PMID: 24672781    Free PMC article.
Review.
Effect of the premalignant and tumor microenvironment on immune cell cytokine production in head and neck cancer.
Sara D Johnson, Anna-Maria A De Costa, M Rita I Young.
Cancers (Basel), 2014 Apr 05; 6(2). PMID: 24698959    Free PMC article.
Signaling pathways involved in MDSC regulation.
Prashant Trikha, William E Carson.
Biochim Biophys Acta, 2014 Apr 15; 1846(1). PMID: 24727385    Free PMC article.
Highly Cited. Review.
Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients.
Yazan S Khaled, Basil J Ammori, Eyad Elkord.
J Immunol Res, 2014 Apr 18; 2014. PMID: 24741628    Free PMC article.
Control of the immune response by pro-angiogenic factors.
Thibault Voron, Elie Marcheteau, +4 authors, Magali Terme.
Front Oncol, 2014 Apr 26; 4. PMID: 24765614    Free PMC article.
Highly Cited. Review.
Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling.
Fei Yang, Yinxiang Wei, +8 authors, Jianli Wang.
Cell Mol Immunol, 2014 Apr 29; 12(1). PMID: 24769795    Free PMC article.
The impact of the immune system on tumor: angiogenesis and vascular remodeling.
Christian Stockmann, Dirk Schadendorf, Ralph Klose, Iris Helfrich.
Front Oncol, 2014 May 02; 4. PMID: 24782982    Free PMC article.
Review.
Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications.
C Marcela Diaz-Montero, Jim Finke, Alberto J Montero.
Semin Oncol, 2014 May 03; 41(2). PMID: 24787291    Free PMC article.
Highly Cited. Review.
Myeloid derived suppressor cells - a new therapeutic target in the treatment of cancer.
Robert Wesolowski, Joseph Markowitz, William E Carson.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829747    Free PMC article.
Highly Cited. Review.
Vaccination with dendritic cells loaded with allogeneic brain tumor cells for recurrent malignant brain tumors induces a CD4(+)IL17(+) response.
Michael R Olin, Walter Low, +10 authors, Christopher Moertel.
J Immunother Cancer, 2014 May 16; 2. PMID: 24829761    Free PMC article.
Gr-1 Ab administered after bone marrow transplantation plus thymus transplantation suppresses tumor growth by depleting granulocytic myeloid-derived suppressor cells.
Ming Shi, Ming Li, +2 authors, Susumu Ikehara.
PLoS One, 2014 May 23; 9(5). PMID: 24847950    Free PMC article.
Attenuated Listeria monocytogenes: a powerful and versatile vector for the future of tumor immunotherapy.
Laurence M Wood, Yvonne Paterson.
Front Cell Infect Microbiol, 2014 May 27; 4. PMID: 24860789    Free PMC article.
Review.
The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment.
Ronit Vogt Sionov, Zvi G Fridlender, Zvi Granot.
Cancer Microenviron, 2014 Jun 05; 8(3). PMID: 24895166    Free PMC article.
Highly Cited.
Rac1 regulates skin tumors by regulation of keratin 17 through recruitment and interaction with CD11b+Gr1+ cells.
Rongyi Chen, Meng Fu, +6 authors, Zhipeng Wang.
Oncotarget, 2014 Jun 26; 5(12). PMID: 24962779    Free PMC article.
MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis.
Clara McClure, Laura Brudecki, +4 authors, Mohamed El Gazzar.
Infect Immun, 2014 Jul 02; 82(9). PMID: 24980967    Free PMC article.
The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury.
Wenli Diao, Fangfang Jin, +4 authors, Limin Li.
Protein Cell, 2014 Jul 02; 5(9). PMID: 24981055    Free PMC article.
Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors.
By Gan Zhao, John P Vasilakos, +2 authors, Dennis M Klinman.
J Immunother Cancer, 2014 Jul 02; 2. PMID: 24982761    Free PMC article.
Myeloid-derived suppressor cells in sepsis.
Dengming Lai, Chaojin Qin, Qiang Shu.
Biomed Res Int, 2014 Jul 06; 2014. PMID: 24995313    Free PMC article.
Review.
Dissecting the role of bone marrow stromal cells on bone metastases.
Denise Buenrostro, Serk In Park, Julie A Sterling.
Biomed Res Int, 2014 Jul 24; 2014. PMID: 25054153    Free PMC article.
Review.
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.
Sandra S McAllister, Robert A Weinberg.
Nat Cell Biol, 2014 Aug 02; 16(8). PMID: 25082194    Free PMC article.
Highly Cited. Review.
Microenvironment, oncoantigens, and antitumor vaccination: lessons learned from BALB-neuT mice.
Laura Conti, Roberto Ruiu, +4 authors, Stefania Lanzardo.
Biomed Res Int, 2014 Aug 20; 2014. PMID: 25136593    Free PMC article.
Review.
MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth.
Junfeng Wang, Fang Yu, +5 authors, Daping Fan.
Int J Cancer, 2014 Aug 22; 136(6). PMID: 25143000    Free PMC article.
Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function.
Eva Sahakian, John J Powers, +12 authors, Javier Pinilla-Ibarz.
Mol Immunol, 2014 Aug 27; 63(2). PMID: 25155994    Free PMC article.
Complex role for the immune system in initiation and progression of pancreatic cancer.
Kristin S Inman, Amanda A Francis, Nicole R Murray.
World J Gastroenterol, 2014 Aug 30; 20(32). PMID: 25170202    Free PMC article.
Review.
Functional significance of mononuclear phagocyte populations generated through adult hematopoiesis.
Michael F Gutknecht, Amy H Bouton.
J Leukoc Biol, 2014 Sep 17; 96(6). PMID: 25225678    Free PMC article.
Review.
IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
Miao-Fen Chen, Feng-Che Kuan, +5 authors, Kuan-Der Lee.
Oncotarget, 2014 Sep 23; 5(18). PMID: 25238263    Free PMC article.
Stromal-dependent tumor promotion by MIF family members.
Robert A Mitchell, Kavitha Yaddanapudi.
Cell Signal, 2014 Oct 04; 26(12). PMID: 25277536    Free PMC article.
Review.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma.
Donald T Weed, Jennifer L Vella, +7 authors, Paolo Serafini.
Clin Cancer Res, 2014 Oct 17; 21(1). PMID: 25320361    Free PMC article.
Highly Cited.
Dopamine inhibits the function of Gr-1+CD115+ myeloid-derived suppressor cells through D1-like receptors and enhances anti-tumor immunity.
Jin Wu, Ruihua Zhang, +5 authors, Wei Cai.
J Leukoc Biol, 2014 Oct 25; 97(1). PMID: 25341727    Free PMC article.
Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state.
Miki Tongu, Nanae Harashima, +2 authors, Mamoru Harada.
Cancer Sci, 2014 Nov 05; 106(1). PMID: 25363339    Free PMC article.
Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow.
Júlia Kurkó, András Vida, +5 authors, Katalin Mikecz.
PLoS One, 2014 Nov 05; 9(11). PMID: 25369029    Free PMC article.
Immunological basis in the pathogenesis and treatment of bladder cancer.
David B Thompson, Larry E Siref, +2 authors, Devendra K Agrawal.
Expert Rev Clin Immunol, 2014 Nov 14; 11(2). PMID: 25391391    Free PMC article.
Review.
Increased circulating myeloid-derived suppressor cells correlate with cancer stages, interleukin-8 and -6 in prostate cancer.
Ning Chi, Zhaohui Tan, +2 authors, Zhizhong Yun.
Int J Clin Exp Med, 2014 Nov 25; 7(10). PMID: 25419348    Free PMC article.
Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy.
Michelle N Messmer, Colleen S Netherby, Debarati Banik, Scott I Abrams.
Cancer Immunol Immunother, 2014 Nov 30; 64(1). PMID: 25432147    Free PMC article.
Review.
A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients.
Eleni-Kyriaki Vetsika, Filippos Koinis, +6 authors, Athanasios Kotsakis.
J Immunol Res, 2014 Dec 02; 2014. PMID: 25436215    Free PMC article.
Dendritic cell defects in the colorectal cancer.
Annalisa Legitimo, Rita Consolini, +2 authors, Roberto Spisni.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483675    Free PMC article.
Review.
Complexity and challenges in defining myeloid-derived suppressor cells.
Vera Damuzzo, Laura Pinton, +4 authors, Susanna Mandruzzato.
Cytometry B Clin Cytom, 2014 Dec 17; 88(2). PMID: 25504825    Free PMC article.
Review.
Immune regulation of bone metastasis.
Aude-Hélène Capietto, Roberta Faccio.
Bonekey Rep, 2014 Dec 17; 3. PMID: 25512853    Free PMC article.
Review.
Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes.
Baisakhi Raychaudhuri, Patricia Rayman, +4 authors, Michael A Vogelbaum.
J Neurooncol, 2015 Jan 13; 122(2). PMID: 25579983
A method for identification and analysis of non-overlapping myeloid immunophenotypes in humans.
Michael P Gustafson, Yi Lin, +5 authors, Allan B Dietz.
PLoS One, 2015 Mar 24; 10(3). PMID: 25799053    Free PMC article.
Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T.
Rachel A Burga, Mitchell Thorn, +8 authors, Steven C Katz.
Cancer Immunol Immunother, 2015 Apr 09; 64(7). PMID: 25850344    Free PMC article.
Granulocytic myeloid derived suppressor cells expansion during active pulmonary tuberculosis is associated with high nitric oxide plasma level.
Sary El Daker, Alessandra Sacchi, +7 authors, Angelo Martino.
PLoS One, 2015 Apr 17; 10(4). PMID: 25879532    Free PMC article.
Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.
Gang Xiao, Xuanjun Wang, +3 authors, Jennifer D Wu.
J Hematol Oncol, 2015 Apr 19; 8. PMID: 25887583    Free PMC article.
Bone specific immunity and its impact on metastasis.
Nikola Baschuk, Jay Rautela, Belinda S Parker.
Bonekey Rep, 2015 Apr 25; 4. PMID: 25908968    Free PMC article.
Review.
Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment.
María F Harman, Romina P Ranocchia, +6 authors, María C Pistoresi-Palencia.
Oncotarget, 2015 Apr 30; 6(15). PMID: 25922914    Free PMC article.
Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation.
Marianna Papaspyridonos, Irina Matei, +18 authors, David Lyden.
Nat Commun, 2015 Apr 30; 6. PMID: 25924227    Free PMC article.
Location, location, location: functional and phenotypic heterogeneity between tumor-infiltrating and non-infiltrating myeloid-derived suppressor cells.
Sarah K Maenhout, Kris Thielemans, Joeri L Aerts.
Oncoimmunology, 2015 May 06; 3(10). PMID: 25941577    Free PMC article.
Review.
Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy.
Oana Draghiciu, Joyce Lubbers, Hans W Nijman, Toos Daemen.
Oncoimmunology, 2015 May 08; 4(1). PMID: 25949858    Free PMC article.
Highly Cited. Review.
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.
Oana Draghiciu, Hans W Nijman, +2 authors, Toos Daemen.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949902    Free PMC article.
Natural killer T cell activation overcomes immunosuppression to enhance clearance of postsurgical breast cancer metastasis in mice.
Simon Gebremeskel, Daniel R Clattenburg, +2 authors, Brent Johnston.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949924    Free PMC article.
Circulating CD14(+)HLA-DR(-/low) myeloid-derived suppressor cell is an indicator of poor prognosis in patients with ESCC.
Haitao Huang, Guangbo Zhang, +2 authors, Xueguang Zhang.
Tumour Biol, 2015 May 15; 36(10). PMID: 25967454
Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
Jessica R Hitchcock, Christine J Watson.
Breast Cancer Res, 2015 May 21; 17. PMID: 25990313    Free PMC article.
Bone-immune cell crosstalk: bone diseases.
Giorgio Mori, Patrizia D'Amelio, Roberta Faccio, Giacomina Brunetti.
J Immunol Res, 2015 May 23; 2015. PMID: 26000310    Free PMC article.
Review.
Inflammation fuels tumor progress and metastasis.
Jingyi Liu, Pengnian Charles Lin, Binhua P Zhou.
Curr Pharm Des, 2015 May 26; 21(21). PMID: 26004407    Free PMC article.
Review.
Melanoma-derived factors alter the maturation and activation of differentiated tissue-resident dendritic cells.
Kristian M Hargadon, Johnathan D Bishop, +3 authors, Osric A Forrest.
Immunol Cell Biol, 2015 May 27; 94(1). PMID: 26010746
Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma.
Mehrdad Talebian Yazdi, Nikki M Loof, +5 authors, Sjoerd H van der Burg.
Cancer Immunol Immunother, 2015 May 31; 64(9). PMID: 26025564    Free PMC article.
The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors.
Lucia D'Amico, Ilaria Roato.
J Immunol Res, 2015 Jun 13; 2015. PMID: 26064994    Free PMC article.
Review.
A top-down view of the tumor microenvironment: structure, cells and signaling.
Rahul Bhome, Marc D Bullock, +4 authors, Alex H Mirnezami.
Front Cell Dev Biol, 2015 Jun 16; 3. PMID: 26075202    Free PMC article.
Review.
Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer.
Hiroshi Katoh, Masahiko Watanabe.
Mediators Inflamm, 2015 Jun 17; 2015. PMID: 26078490    Free PMC article.
Review.
Challenges and future perspectives of T cell immunotherapy in cancer.
Maria Teresa P de Aquino, Anshu Malhotra, Manoj K Mishra, Anil Shanker.
Immunol Lett, 2015 Jun 23; 166(2). PMID: 26096822    Free PMC article.
Review.
The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis.
Francesca Grasso, Serena Di Meo, +6 authors, Emma Di Carlo.
Oncotarget, 2015 Jun 26; 6(23). PMID: 26109431    Free PMC article.
The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression.
Alfred P See, Jonathon J Parker, Allen Waziri.
J Neurooncol, 2015 Jul 01; 123(3). PMID: 26123363
Review.
Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis.
Xin Liu, Xiangrui Ma, +10 authors, Xinhua Liang.
PLoS One, 2015 Jul 21; 10(7). PMID: 26193368    Free PMC article.
Myeloid-Derived Suppressor Cells: Critical Cells Driving Immune Suppression in the Tumor Microenvironment.
Katherine H Parker, Daniel W Beury, Suzanne Ostrand-Rosenberg.
Adv Cancer Res, 2015 Jul 29; 128. PMID: 26216631    Free PMC article.
Highly Cited. Review.
The Dynamics of Interactions Among Immune and Glioblastoma Cells.
Katalin Eder, Bernadette Kalman.
Neuromolecular Med, 2015 Aug 01; 17(4). PMID: 26224516
Review.
Big opportunities for small molecules in immuno-oncology.
Jerry L Adams, James Smothers, Roopa Srinivasan, Axel Hoos.
Nat Rev Drug Discov, 2015 Aug 01; 14(9). PMID: 26228631
Highly Cited. Review.
Immature myeloid cells and tolerogenic cytokine profile in lung adenocarcinoma metastatic lymph nodes assessed by endobronchial ultrasound.
Antonio Bugalho, Catarina Martins, +4 authors, Paula A Videira.
Tumour Biol, 2015 Aug 13; 37(1). PMID: 26264617
Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia.
Hui Sun, Yi Li, +4 authors, Bin Liu.
Int J Hematol, 2015 Sep 12; 102(5). PMID: 26358057
The nitric oxide radical scavenger carboxy-PTIO reduces the immunosuppressive activity of myeloid-derived suppressor cells and potentiates the antitumor activity of adoptive cytotoxic T lymphocyte immunotherapy.
Kosuke Hirano, Akihiro Hosoi, +5 authors, Kazuhiro Kakimi.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405569    Free PMC article.
Cancer associated fibroblasts have phenotypic and functional characteristics similar to the fibrocytes that represent a novel MDSC subset.
Gurcan Gunaydin, S Altug Kesikli, Dicle Guc.
Oncoimmunology, 2015 Sep 26; 4(9). PMID: 26405600    Free PMC article.
Tolerance and immune suppression in the tumor microenvironment.
Suzanne Ostrand-Rosenberg.
Cell Immunol, 2015 Oct 06; 299. PMID: 26435343    Free PMC article.
Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer.
Diana L Moughon, Huanhuan He, +7 authors, Lily Wu.
Cancer Res, 2015 Oct 17; 75(22). PMID: 26471360    Free PMC article.
CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ.
Hangyi H Yan, Jian Jiang, +7 authors, Li Yang.
Cancer Res, 2015 Oct 21; 75(24). PMID: 26483204    Free PMC article.
T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1.
Malika Trad, Alexandrine Gautheron, +13 authors, Bernard Bonnotte.
Biomed Res Int, 2015 Oct 23; 2015. PMID: 26491691    Free PMC article.
Immunosuppressive mechanisms in glioblastoma.
Edjah K Nduom, Michael Weller, Amy B Heimberger.
Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516226    Free PMC article.
Highly Cited. Review.
Hepatic immune tolerance induced by hepatic stellate cells.
Ching-Chuan Hsieh, Chien-Hui Hung, Lina Lu, Shiguang Qian.
World J Gastroenterol, 2015 Nov 18; 21(42). PMID: 26576077    Free PMC article.
Review.
The immunobiology of myeloid-derived suppressor cells in cancer.
Morteza Motallebnezhad, Farhad Jadidi-Niaragh, +3 authors, Mehdi Yousefi.
Tumour Biol, 2015 Nov 28; 37(2). PMID: 26611648
Review.
Immunosuppressive cells in tumor immune escape and metastasis.
Yang Liu, Xuetao Cao.
J Mol Med (Berl), 2015 Dec 23; 94(5). PMID: 26689709
Review.
Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study.
Susanna Mandruzzato, Sven Brandau, +8 authors, Steffen Walter.
Cancer Immunol Immunother, 2016 Jan 06; 65(2). PMID: 26728481    Free PMC article.
Highly Cited.
Yeast-Derived Particulate β-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer.
Sabrin H Albeituni, Chuanlin Ding, +6 authors, Jun Yan.
J Immunol, 2016 Jan 27; 196(5). PMID: 26810222    Free PMC article.
Neutrophils in Cancer: Two Sides of the Same Coin.
Eileen Uribe-Querol, Carlos Rosales.
J Immunol Res, 2016 Jan 29; 2015. PMID: 26819959    Free PMC article.
Highly Cited. Review.
Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden.
Ke Rui, Jie Tian, +7 authors, Shengjun Wang.
Immunol Res, 2016 Feb 03; 64(4). PMID: 26832917
mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors.
Tingting Wu, Yang Zhao, +7 authors, Yong Zhao.
Sci Rep, 2016 Feb 03; 6. PMID: 26833095    Free PMC article.
Tumour progression and metastasis.
Francisco Arvelo, Felipe Sojo, Carlos Cotte.
Ecancermedicalscience, 2016 Feb 26; 10. PMID: 26913068    Free PMC article.
Review.
Myeloid Derived Suppressor Cells: Fuel the Fire.
B R Achyut, Ali S Arbab.
Biochem Physiol, 2014 Aug 01; 3(3). PMID: 26925346    Free PMC article.
Influence of Immune Myeloid Cells on the Extracellular Matrix During Cancer Metastasis.
David Jiang, Su Yin Lim.
Cancer Microenviron, 2016 Mar 10; 9(1). PMID: 26956475    Free PMC article.
Review.
Current understanding of the tumor microenvironment of laryngeal dysplasia and progression to invasive cancer.
Sumita Trivedi, Clark A Rosen, Robert L Ferris.
Curr Opin Otolaryngol Head Neck Surg, 2016 Mar 11; 24(2). PMID: 26963671    Free PMC article.
Review.
Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy.
Inès Dufait, Els Van Valckenborgh, +3 authors, Karine Breckpot.
Oncotarget, 2016 Mar 31; 7(27). PMID: 27029037    Free PMC article.
Review.
Myeloid cell signatures in tumor microenvironment predicts therapeutic response in cancer.
Bhagelu R Achyut, Ali S Arbab.
Onco Targets Ther, 2016 Apr 05; 9. PMID: 27042097    Free PMC article.
Review.
Phenotype, development, and biological function of myeloid-derived suppressor cells.
Yang Zhao, Tingting Wu, +2 authors, Yong Zhao.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057424    Free PMC article.
Highly Cited. Review.
Myeloid-Derived Suppressor Cells in Bacterial Infections.
Michael Ost, Anurag Singh, +3 authors, Dominik Hartl.
Front Cell Infect Microbiol, 2016 Apr 12; 6. PMID: 27066459    Free PMC article.
Review.
Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.
Asaf Spiegel, Mary W Brooks, +14 authors, Robert A Weinberg.
Cancer Discov, 2016 Apr 14; 6(6). PMID: 27072748    Free PMC article.
Highly Cited.
Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy.
Wei He, Pei Liang, +5 authors, Junfeng Zhang.
Sci Rep, 2016 Apr 15; 6. PMID: 27074905    Free PMC article.
Regulation of Natural Killer Cell Function by STAT3.
Nicholas A Cacalano.
Front Immunol, 2016 May 06; 7. PMID: 27148255    Free PMC article.
Review.
TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation.
Kamar-Sulu N Atretkhany, Maxim A Nosenko, +4 authors, Marina S Drutskaya.
Front Immunol, 2016 May 06; 7. PMID: 27148266    Free PMC article.
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Thomas Welte, Ik Sun Kim, +23 authors, Xiang H-F Zhang.
Nat Cell Biol, 2016 May 18; 18(6). PMID: 27183469    Free PMC article.
Highly Cited.
Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.
Ruth J Davis, Carter Van Waes, Clint T Allen.
Oral Oncol, 2016 May 25; 58. PMID: 27215705    Free PMC article.
Review.
mTOR inhibitors effects on regulatory T cells and on dendritic cells.
Giovanni Stallone, Barbara Infante, +3 authors, Giuseppe Grandaliano.
J Transl Med, 2016 Jun 02; 14(1). PMID: 27245075    Free PMC article.
Review.
M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation.
Makiko Okubo, Mitomu Kioi, +5 authors, Iwai Tohnai.
Sci Rep, 2016 Jun 09; 6. PMID: 27271009    Free PMC article.
High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1.
Jennifer L Schehr, Zachery D Schultz, +12 authors, Joshua M Lang.
PLoS One, 2016 Jul 28; 11(7). PMID: 27459545    Free PMC article.
Molecular mechanisms involved in dendritic cell dysfunction in cancer.
Michael Tang, Jun Diao, Mark S Cattral.
Cell Mol Life Sci, 2016 Aug 06; 74(5). PMID: 27491428
Review.
Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model.
Guangfu Li, Dai Liu, +12 authors, Kevin F Staveley-O'Carroll.
J Hepatol, 2016 Aug 16; 66(1). PMID: 27520877    Free PMC article.
Suppressive role of myeloid-derived suppressor cells (MDSCs) in the microenvironment of breast cancer and targeted immunotherapies.
Dawei Shou, Liang Wen, +3 authors, Weihua Gong.
Oncotarget, 2016 Aug 20; 7(39). PMID: 27542274    Free PMC article.
Review.
Myeloid-derived suppressor cells are elevated in patients with psoriasis and produce various molecules.
Dan Ilkovitch, Laura K Ferris.
Mol Med Rep, 2016 Aug 31; 14(4). PMID: 27574042    Free PMC article.
Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells.
Y Deng, J Cheng, +4 authors, Y Yang.
Oncogene, 2016 Sep 07; 36(8). PMID: 27593937
Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β.
Jessica L Rastad, William R Green.
Virology, 2016 Sep 16; 499. PMID: 27632561    Free PMC article.
On the origin of myeloid-derived suppressor cells.
Camilla Rydberg Millrud, Caroline Bergenfelz, Karin Leandersson.
Oncotarget, 2016 Oct 01; 8(2). PMID: 27690299    Free PMC article.
Review.
C-C Chemokine Receptor Type 2-Dependent Migration of Myeloid-Derived Suppressor Cells in Protection of Islet Transplants.
Jie Qin, Yusuke Arakawa, +3 authors, Lina Lu.
Transplantation, 2016 Oct 22; 101(8). PMID: 27755503    Free PMC article.
Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy.
Neha Kamran, Mayuri Chandran, Pedro R Lowenstein, Maria G Castro.
Clin Immunol, 2016 Nov 04; 189. PMID: 27777083    Free PMC article.
Review.
One microenvironment does not fit all: heterogeneity beyond cancer cells.
Ik Sun Kim, Xiang H-F Zhang.
Cancer Metastasis Rev, 2016 Nov 20; 35(4). PMID: 27858305    Free PMC article.
Review.
IL-17A produced by peritoneal macrophages promote the accumulation and function of granulocytic myeloid-derived suppressor cells in the development of colitis-associated cancer.
Yue Zhang, Juan Wang, +6 authors, Shengjun Wang.
Tumour Biol, 2016 Dec 03;. PMID: 27909978
The diverse roles of the TNF axis in cancer progression and metastasis.
Boram Ham, Maria Celia Fernandez, Zarina D'Costa, Pnina Brodt.
Trends Cancer Res, 2016 Dec 09; 11(1). PMID: 27928197    Free PMC article.
Role of immune cells in pancreatic cancer from bench to clinical application: An updated review.
Jae Hyuck Chang, Yongjian Jiang, Venu G Pillarisetty.
Medicine (Baltimore), 2016 Dec 09; 95(49). PMID: 27930550    Free PMC article.
Review.
Frontline Science: Myeloid-derived suppressor cells (MDSCs) facilitate maternal-fetal tolerance in mice.
Suzanne Ostrand-Rosenberg, Pratima Sinha, +4 authors, Virginia K Clements.
J Leukoc Biol, 2016 Dec 23; 101(5). PMID: 28007981    Free PMC article.
Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients.
Salman M Toor, Azharuddin Sajid Syed Khaja, +4 authors, Eyad Elkord.
Front Immunol, 2016 Dec 23; 7. PMID: 28008330    Free PMC article.
Myeloid-derived suppressor cells mediate tolerance induction in autoimmune disease.
Anja Wegner, Johan Verhagen, David C Wraith.
Immunology, 2017 Feb 01; 151(1). PMID: 28140447    Free PMC article.
The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.
Andrew M K Law, Elgene Lim, Christopher J Ormandy, David Gallego-Ortega.
Endocr Relat Cancer, 2017 Feb 15; 24(4). PMID: 28193698    Free PMC article.
Review.
Myeloid cells in circulation and tumor microenvironment of breast cancer patients.
Salman M Toor, Azharuddin Sajid Syed Khaja, +5 authors, Eyad Elkord.
Cancer Immunol Immunother, 2017 Mar 12; 66(6). PMID: 28283696    Free PMC article.
Myeloid-derived suppressor cells and myeloid regulatory cells in cancer and autoimmune disorders.
Prince Amoah Barnie, Pan Zhang, +4 authors, Huaxi Xu.
Exp Ther Med, 2017 Mar 30; 13(2). PMID: 28352304    Free PMC article.
Myeloid-derived suppressor cells in gliomas.
Anna Gieryng, Bozena Kaminska.
Contemp Oncol (Pozn), 2016 Jan 01; 20(5). PMID: 28373814    Free PMC article.
Review.
Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques.
Yongjun Sui, Blake Frey, +7 authors, Jay A Berzofsky.
PLoS Pathog, 2017 May 13; 13(5). PMID: 28498847    Free PMC article.
Heterogeneity Among Neutrophils.
Marzena Garley, Ewa Jabłońska.
Arch Immunol Ther Exp (Warsz), 2017 Jun 01; 66(1). PMID: 28560557    Free PMC article.
Review.
Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.
Mira M Shenouda, Amy Gillgrass, +10 authors, Ali A Ashkar.
Breast Cancer Res, 2017 Jul 03; 19(1). PMID: 28668076    Free PMC article.
Recruitment of CD11b+Ly6C+ monocytes in non-small cell lung cancer xenografts challenged by anti-VEGF antibody.
Xie-Wan Chen, Jian-Guo Sun, +2 authors, Rong-Xia Liao.
Oncol Lett, 2017 Jul 12; 14(1). PMID: 28693213    Free PMC article.
Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants.
Javier Sánchez Ramírez, Yanelys Morera Díaz, +10 authors, Marta Ayala Avila.
BMC Immunol, 2017 Jul 28; 18(1). PMID: 28747172    Free PMC article.
Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer.
Kenji Gonda, Masahiko Shibata, +6 authors, Seiichi Takenoshita.
Oncol Lett, 2017 Aug 10; 14(2). PMID: 28789407    Free PMC article.
The Emerging Roles of Extracellular Vesicles As Communication Vehicles within the Tumor Microenvironment and Beyond.
Ryan Sullivan, Grace Maresh, +4 authors, Li Li.
Front Endocrinol (Lausanne), 2017 Aug 30; 8. PMID: 28848498    Free PMC article.
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A brief review of clinical trials involving manipulation of invariant NKT cells as a promising approach in future cancer therapies.
Małgorzata Waldowska, Agnieszka Bojarska-Junak, Jacek Roliński.
Cent Eur J Immunol, 2017 Sep 02; 42(2). PMID: 28860937    Free PMC article.
Review.
Myeloid-derived suppressor cell and macrophage exert distinct angiogenic and immunosuppressive effects in breast cancer.
Zhaoxu Fang, Chengwen Wen, +4 authors, Yuhui Huang.
Oncotarget, 2017 Sep 15; 8(33). PMID: 28903332    Free PMC article.
Nanomaterials for cancer immunotherapy.
Wantong Song, Sara N Musetti, Leaf Huang.
Biomaterials, 2017 Sep 30; 148. PMID: 28961532    Free PMC article.
Review.
Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with malignant solid tumors.
Tomoro Hishiki, Naoko Mise, +8 authors, Shinichiro Motohashi.
Pediatr Surg Int, 2017 Oct 12; 34(2). PMID: 29018953
Microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy.
Ruixue Ai, Yan Tao, +6 authors, Qianming Chen.
Oncotarget, 2017 Nov 09; 8(46). PMID: 29113419    Free PMC article.
Review.
Modulation of antigen presenting cell functions during chronic HPV infection.
Abate Assefa Bashaw, Graham R Leggatt, +2 authors, Ian H Frazer.
Papillomavirus Res, 2017 Nov 29; 4. PMID: 29179871    Free PMC article.
Review.
Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice.
Aitor Benedicto, Joana Marquez, +3 authors, Beatriz Arteta.
BMC Cancer, 2017 Dec 07; 17(1). PMID: 29207960    Free PMC article.
The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy.
Hirokazu Shoji, Kohei Tada, +14 authors, Tetsuya Hamaguchi.
Oncotarget, 2017 Dec 10; 8(56). PMID: 29221113    Free PMC article.
The role of STAT3 in leading the crosstalk between human cancers and the immune system.
Yu Wang, Yicheng Shen, +2 authors, Xuan Zhou.
Cancer Lett, 2017 Dec 10; 415. PMID: 29222039    Free PMC article.
Highly Cited. Review.
Efferocytosis creates a tumor microenvironment supportive of tumor survival and metastasis.
David B Vaught, Jamie C Stanford, Rebecca S Cook.
Cancer Cell Microenviron, 2015 Jan 01; 2(1). PMID: 29264372    Free PMC article.
Carcinogenesis-relevant biological events in the pathophysiology of the efferocytosis phenomenon.
Gargi Sachin Sarode, Sachin C Sarode, +2 authors, Shankargouda Patil.
Oncol Rev, 2017 Dec 30; 11(2). PMID: 29285321    Free PMC article.
Review.
Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment.
Suzanne Ostrand-Rosenberg, Catherine Fenselau.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311384    Free PMC article.
Highly Cited. Review.
LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.
Masoud F Tavazoie, Ilana Pollack, +21 authors, Sohail F Tavazoie.
Cell, 2018 Jan 18; 172(4). PMID: 29336888    Free PMC article.
Highly Cited.
Interferon-γ and Colorectal Cancer: an up-to date.
Christoforos Kosmidis, Konstantinos Sapalidis, +20 authors, Isaac Kesisoglou.
J Cancer, 2018 Jan 19; 9(2). PMID: 29344268    Free PMC article.
Review.
Use of antigen-primed dendritic cells for inducing antitumor immune responses in vitro in patients with non-small cell lung cancer.
Irina Obleukhova, Nataliya Kiryishina, +7 authors, Sergey Sennikov.
Oncol Lett, 2018 Feb 06; 15(1). PMID: 29399182    Free PMC article.
MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages.
Graziella Curtale.
Cells, 2018 Feb 09; 7(2). PMID: 29419779    Free PMC article.
Review.
Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms.
Dmitri Negorev, Ulf H Beier, +11 authors, Tatiana Akimova.
Sci Rep, 2018 Feb 18; 8(1). PMID: 29453429    Free PMC article.
Targeting complement-mediated immunoregulation for cancer immunotherapy.
Martin Kolev, Maciej M Markiewski.
Semin Immunol, 2018 Feb 20; 37. PMID: 29454575    Free PMC article.
Review.
Myeloid-derived suppressor cells increase and inhibit donor-reactive T cell responses to graft intestinal epithelium in intestinal transplant patients.
Shinji Okano, Kareem Abu-Elmagd, +11 authors, Koji Hashimoto.
Am J Transplant, 2018 Mar 07; 18(10). PMID: 29509288    Free PMC article.
Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression.
Viktor Fleming, Xiaoying Hu, +5 authors, Viktor Umansky.
Front Immunol, 2018 Mar 20; 9. PMID: 29552012    Free PMC article.
Highly Cited. Review.
Transcriptional Regulation of Emergency Granulopoiesis in Leukemia.
Shirin Hasan, Afsar R Naqvi, Asim Rizvi.
Front Immunol, 2018 Mar 30; 9. PMID: 29593731    Free PMC article.
Review.
The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas.
Luyan Mu, Yu Long, +12 authors, Jianping Huang.
Front Mol Neurosci, 2018 Apr 13; 11. PMID: 29643764    Free PMC article.
Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.
Tobias Neumann, Özge Canli, Florian R Greten.
Oncotarget, 2018 Apr 24; 9(24). PMID: 29682184    Free PMC article.
Neutrophil phenotypes in health and disease.
Pien Hellebrekers, Nienke Vrisekoop, Leo Koenderman.
Eur J Clin Invest, 2018 Apr 24; 48 Suppl 2. PMID: 29682724    Free PMC article.
Review.
Synergistic anti-tumor effects of dasatinib and dendritic cell vaccine on metastatic breast cancer in a mouse model.
Ningning Song, Hulin Guo, +2 authors, Xinchao Wang.
Oncol Lett, 2018 May 08; 15(5). PMID: 29731862    Free PMC article.
Circulating and tumor-infiltrating myeloid-derived suppressor cells in cervical carcinoma patients.
Liangliang Wu, Hongyu Liu, +11 authors, Tianyi Liu.
Oncol Lett, 2018 May 31; 15(6). PMID: 29844835    Free PMC article.
The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma.
Demi S Houg, Maarten F Bijlsma.
Mol Cancer, 2018 Jun 16; 17(1). PMID: 29903049    Free PMC article.
Review.
The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer.
Tongwen Ou, Michael Lilly, Wei Jiang.
Front Immunol, 2018 Jun 22; 9. PMID: 29928275    Free PMC article.
Review.
Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma.
Janet Retseck, Alexis Nasr, +4 authors, Ahmad A Tarhini.
J Transl Med, 2018 Jul 06; 16(1). PMID: 29973204    Free PMC article.
Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy.
Nobuo Kondoh, Masako Mizuno-Kamiya, +5 authors, Iwai Tohnai.
Open Dent J, 2018 Jul 11; 12. PMID: 29988281    Free PMC article.
Review.
IRX-2 natural cytokine biologic for immunotherapy in patients with head and neck cancers.
Gregory T Wolf, Jeffrey S Moyer, +4 authors, Theresa L Whiteside.
Onco Targets Ther, 2018 Jul 11; 11. PMID: 29988729    Free PMC article.
Review.
Targeting the Microenvironment in High Grade Serous Ovarian Cancer.
Nkechiyere G Nwani, Livia E Sima, Wilberto Nieves-Neira, Daniela Matei.
Cancers (Basel), 2018 Aug 15; 10(8). PMID: 30103384    Free PMC article.
Review.
The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer.
Alison Caldwell, Rachel Coleby, +11 authors, Hannah Vt Siddle.
Elife, 2018 Aug 15; 7. PMID: 30103855    Free PMC article.
Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer.
Daniela Cornelia Lazăr, Mihaela Flavia Avram, +3 authors, Adrian Goldiș.
World J Gastroenterol, 2018 Sep 01; 24(32). PMID: 30166856    Free PMC article.
Highly Cited. Review.
Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine.
Florent Petitprez, Cheng-Ming Sun, +3 authors, Wolf H Fridman.
Front Oncol, 2018 Oct 16; 8. PMID: 30319963    Free PMC article.
Review.
Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines.
Sruthi Ravindranathan, Khue G Nguyen, +5 authors, David A Zaharoff.
Breast Cancer Res, 2018 Oct 24; 20(1). PMID: 30348199    Free PMC article.
Update on Neutrophil Function in Severe Inflammation.
Esmaeil Mortaz, Shamila D Alipoor, +2 authors, Leo Koenderman.
Front Immunol, 2018 Oct 26; 9. PMID: 30356867    Free PMC article.
Review.
Radiogenomics Profiling for Glioblastoma-related Immune Cells Reveals CD49d Expression Correlation with MRI parameters and Prognosis.
Hye Rim Cho, Hyejin Jeon, +2 authors, Seung Hong Choi.
Sci Rep, 2018 Oct 31; 8(1). PMID: 30375429    Free PMC article.
Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression.
Zhiwu Tan, Li Liu, +7 authors, Zhiwei Chen.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546960    Free PMC article.
Metastasis as a systemic disease: molecular insights and clinical implications.
Maša Alečković, Sandra S McAllister, Kornelia Polyak.
Biochim Biophys Acta Rev Cancer, 2019 Jun 17; 1872(1). PMID: 31202687    Free PMC article.
Review.
STAT3, a Master Regulator of Anti-Tumor Immune Response.
Cédric Rébé, François Ghiringhelli.
Cancers (Basel), 2019 Sep 05; 11(9). PMID: 31480382    Free PMC article.
Review.
Nitric Oxide-Mediated Enhancement and Reversal of Resistance of Anticancer Therapies.
Emily Hays, Benjamin Bonavida.
Antioxidants (Basel), 2019 Sep 20; 8(9). PMID: 31533363    Free PMC article.
Review.
Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment.
Hao Wang, Sha Zhao, +4 authors, Yayi He.
Onco Targets Ther, 2019 Oct 01; 12. PMID: 31564911    Free PMC article.
Dendritic Cells/Macrophages-Targeting Feature of Ebola Glycoprotein and its Potential as Immunological Facilitator for Antiviral Vaccine Approach.
Titus Abiola Olukitibi, Zhujun Ao, +2 authors, Xiaojian Yao.
Microorganisms, 2019 Oct 02; 7(10). PMID: 31569539    Free PMC article.
Review.
Neutrophils as Suppressors of T Cell Proliferation: Does Age Matter?
Cathelijn E M Aarts, Ida H Hiemstra, +4 authors, Taco W Kuijpers.
Front Immunol, 2019 Oct 02; 10. PMID: 31572368    Free PMC article.
Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer.
Philipp Metzger, Sabrina V Kirchleitner, +10 authors, Peter Duewell.
J Immunother Cancer, 2019 Nov 07; 7(1). PMID: 31694706    Free PMC article.
Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair.
Cathelijn E M Aarts, Ida H Hiemstra, +13 authors, Taco W Kuijpers.
Blood Adv, 2019 Nov 19; 3(22). PMID: 31738831    Free PMC article.
Could Increased Expression of Hsp27, an "Anti-Inflammatory" Chaperone, Contribute to the Monocyte-Derived Dendritic Cell Bias towards Tolerance Induction in Breast Cancer Patients?
Ana Paula Silva de Azevedo-Santos, Mirtes Castelo Branco Rocha, +6 authors, José Alexandre Marzagão Barbuto.
Mediators Inflamm, 2019 Dec 13; 2019. PMID: 31827382    Free PMC article.
Unbiased enrichment of urine exfoliated cells on nanostructured substrates for sensitive detection of urothelial tumor cells.
Xin Wang, Yuanyuan Gu, +13 authors, Hongqian Guo.
Cancer Med, 2019 Nov 12; 9(1). PMID: 31709750    Free PMC article.
Febrile Neutropenia in Acute Leukemia. Epidemiology, Etiology, Pathophysiology and Treatment.
Bent-Are Hansen, Øystein Wendelbo, +3 authors, Håkon Reikvam.
Mediterr J Hematol Infect Dis, 2020 Jan 15; 12(1). PMID: 31934319    Free PMC article.
Review.
Tumor-Infiltrating Immunosuppressive Cells in Cancer-Cell Plasticity, Tumor Progression and Therapy Response.
Laura Lorenzo-Sanz, Purificación Muñoz.
Cancer Microenviron, 2019 Oct 05; 12(2-3). PMID: 31583529    Free PMC article.
Dynamic changes in trauma-induced myeloid-derived suppressor cells after polytrauma are associated with an increased susceptibility to infection.
Liang Cheng, Jia Xu, +2 authors, Pei Han.
Int J Clin Exp Pathol, 2017 Nov 01; 10(11). PMID: 31966453    Free PMC article.
Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d-/- Mice Lacking NKT Cells.
Shun Takaku, Masumi Shimizu, Hidemi Takahashi.
Integr Cancer Ther, 2020 Jan 22; 19. PMID: 31959018    Free PMC article.
Myeloid-Derived Suppressor Cells and γδT17 Cells Contribute to the Development of Gastric MALT Lymphoma in H. felis-Infected Mice.
Yanan Zhao, Fei Lu, +9 authors, Chunyan Ji.
Front Immunol, 2020 Feb 18; 10. PMID: 32063899    Free PMC article.
Functional assay to assess T-cell inhibitory properties of myeloid derived suppressor cells (MDSCs) isolated from the tumor microenvironment of murine glioma models.
Mahmoud S Alghamri, Neha Kamran, +2 authors, Maria Graciela Castro.
Methods Enzymol, 2020 Feb 01; 632. PMID: 32000897    Free PMC article.
Mechanisms and immunogenicity of nsPEF-induced cell death in B16F10 melanoma tumors.
Alessandra Rossi, Olga N Pakhomova, +5 authors, Claudia Muratori.
Sci Rep, 2019 Jan 25; 9(1). PMID: 30674926    Free PMC article.
The Yin and Yang of Myeloid Derived Suppressor Cells.
Snehil Budhwar, Priyanka Verma, +2 authors, Kiran Singh.
Front Immunol, 2018 Dec 18; 9. PMID: 30555467    Free PMC article.
Review.
Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment.
Hari Menon, Rishab Ramapriyan, +13 authors, James W Welsh.
Front Immunol, 2019 Mar 05; 10. PMID: 30828330    Free PMC article.
Highly Cited. Review.
Early myeloid-derived suppressor cells (HLA-DR-/lowCD33+CD16-) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT.
Ke Wang, Meng Lv, +15 authors, Xiao-Jun Huang.
J Hematol Oncol, 2019 Mar 20; 12(1). PMID: 30885244    Free PMC article.
NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies.
Michelle A Kelliher, Justine E Roderick.
Front Immunol, 2019 Apr 11; 9. PMID: 30967879    Free PMC article.
Review.
Platinum Derivatives Effects on Anticancer Immune Response.
Cédric Rébé, Lucie Demontoux, Thomas Pilot, François Ghiringhelli.
Biomolecules, 2019 Dec 22; 10(1). PMID: 31861811    Free PMC article.
Review.
Chemokine releasing particle implants for trapping circulating prostate cancer cells.
YiHui Huang, Amirhossein Hakamivala, +4 authors, Liping Tang.
Sci Rep, 2020 Mar 12; 10(1). PMID: 32157115    Free PMC article.
MicroRNA-92 Expression in CD133+ Melanoma Stem Cells Regulates Immunosuppression in the Tumor Microenvironment via Integrin-Dependent Activation of TGFβ.
Chris Shidal, Narendra P Singh, Prakash Nagarkatti, Mitzi Nagarkatti.
Cancer Res, 2019 Apr 25; 79(14). PMID: 31015227    Free PMC article.
Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.
Kumar Vijay.
Int Immunopharmacol, 2018 May 08; 59. PMID: 29730580    Free PMC article.
Highly Cited. Review.
The role of granulocyte colony‑stimulating factor in breast cancer development: A review.
Li Liu, Yangyang Liu, +2 authors, Xiangyang Xiong.
Mol Med Rep, 2020 Mar 19; 21(5). PMID: 32186767    Free PMC article.
Review.
Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment.
Heidi Harjunpää, Marc Llort Asens, Carla Guenther, Susanna C Fagerholm.
Front Immunol, 2019 Jun 25; 10. PMID: 31231358    Free PMC article.
Highly Cited. Review.
Is There a Place for Immunotherapy for Metastatic Microsatellite Stable Colorectal Cancer?
François Ghiringhelli, Jean-David Fumet.
Front Immunol, 2019 Aug 27; 10. PMID: 31447840    Free PMC article.
Review.
Using recursive partitioning approach to select tumor-associated antigens in immunodiagnosis of gastric adenocarcinoma.
Jiejie Qin, Shuaibing Wang, +11 authors, Jianying Zhang.
Cancer Sci, 2019 Apr 06; 110(6). PMID: 30950146    Free PMC article.
Cytokine Syntheses by T-Cell Subsets From Chronic Myeloid Leukemia Patients: Relationship Between Pre-Treatment Levels and Response to Imatinib Therapy.
Inaam B Hassan, Sheela Benedict, Jorgen Kristensen.
J Hematol, 2018 Sep 01; 7(3). PMID: 32300421    Free PMC article.
Cancer-Derived Exosomes as Effectors of Key Inflammation-Related Players.
Norahayu Othman, Rahman Jamal, Nadiah Abu.
Front Immunol, 2019 Sep 27; 10. PMID: 31555295    Free PMC article.
Review.
Role of the Neutrophil in the Pathogenesis of Advanced Cancer and Impaired Responsiveness to Therapy.
Bernardo L Rapoport, Helen C Steel, +2 authors, Ronald Anderson.
Molecules, 2020 Apr 05; 25(7). PMID: 32244751    Free PMC article.
Review.
Doxorubicin pretreatment enhances FAPα/survivin co-targeting DNA vaccine anti-tumor activity primarily through decreasing peripheral MDSCs in the 4T1 murine breast cancer model.
Fei Geng, Xin Bao, +10 authors, Wei Kong.
Oncoimmunology, 2020 May 05; 9(1). PMID: 32363118    Free PMC article.
Myeloid-derived suppressor cells infiltration in non-small-cell lung cancer tumor and MAGE-A4 and NY-ESO-1 expression.
Zhenbo Hou, Xiao Liang, +2 authors, Guilan Shi.
Oncol Lett, 2020 May 10; 19(6). PMID: 32382343    Free PMC article.
Apolipoprotein A-I Mimetic Peptide L-4F Suppresses Granulocytic-Myeloid-Derived Suppressor Cells in Mouse Pancreatic Cancer.
Meiyu Peng, Qi Zhang, +7 authors, Rongxin Zhang.
Front Pharmacol, 2020 May 20; 11. PMID: 32425796    Free PMC article.
Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells.
WeiHong Ren, XuRan Zhang, +8 authors, ShiChun Tu.
Sci Rep, 2020 May 18; 10(1). PMID: 32415175    Free PMC article.
Quantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils.
Anm Nazmul H Khan, Tiffany R Emmons, +10 authors, Brahm H Segal.
Cancer Immunol Res, 2020 Apr 03; 8(6). PMID: 32238380    Free PMC article.
Targeting Myeloid-Derived Suppressor Cell, a Promising Strategy to Overcome Resistance to Immune Checkpoint Inhibitors.
Aohan Hou, Kaiyu Hou, +2 authors, Wanling Chen.
Front Immunol, 2020 Jun 09; 11. PMID: 32508809    Free PMC article.
Review.
Friend or Foe? Recent Strategies to Target Myeloid Cells in Cancer.
Mehdi Chaib, Subhash C Chauhan, Liza Makowski.
Front Cell Dev Biol, 2020 Jun 09; 8. PMID: 32509781    Free PMC article.
Review.
Generation of Myeloid Cells in Cancer: The Spleen Matters.
Chong Wu, Qiaomin Hua, Limin Zheng.
Front Immunol, 2020 Jun 26; 11. PMID: 32582203    Free PMC article.
Review.
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
Min-Hee Oh, Im-Hong Sun, +17 authors, Jonathan D Powell.
J Clin Invest, 2020 Apr 24; 130(7). PMID: 32324593    Free PMC article.
The Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: on Subsets and Subsites.
Niels E Wondergem, Irene H Nauta, +2 authors, Rieneke van de Ven.
Curr Oncol Rep, 2020 Jul 01; 22(8). PMID: 32602047    Free PMC article.
Review.
Stem cell factor produced by tumor cells expands myeloid-derived suppressor cells in mice.
Wei-Chen Lee, Pao-Yueh Hsu, Hsiu-Ying Hsu.
Sci Rep, 2020 Jul 11; 10(1). PMID: 32647215    Free PMC article.
Gr-1highLy6G+Myeloid-derived suppressor cells and their role in a murine model of non-alcoholic steatohepatitis.
Yue Li, Ning Li, Jinchun Liu, Xiuqin An.
Am J Transl Res, 2020 Jul 14; 12(6). PMID: 32655813    Free PMC article.
[Prediction of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation by the level of galectin-9 in peripheral blood].
J Yin, Y Cao, J F Zhou, Y C Zhang.
Zhonghua Xue Ye Xue Za Zhi, 2020 Feb 07; 41(1). PMID: 32023750    Free PMC article.
Interleukin-1β and Cancer.
Cédric Rébé, François Ghiringhelli.
Cancers (Basel), 2020 Jul 09; 12(7). PMID: 32635472    Free PMC article.
Review.
Kras and Tumor Immunity: Friend or Foe?
Jane Cullis, Shipra Das, Dafna Bar-Sagi.
Cold Spring Harb Perspect Med, 2017 Dec 13; 8(9). PMID: 29229670    Free PMC article.
Review.
Negative regulation of myeloid-derived suppressor cells in cancer.
Peng Qu, Kimberly C Boelte, P Charles Lin.
Immunol Invest, 2012 Sep 29; 41(6-7). PMID: 23017135    Free PMC article.
Review.
Mechanisms of T-Cell Exhaustion in Pancreatic Cancer.
Didem Saka, Muazzez Gökalp, +6 authors, Hande Asimgil.
Cancers (Basel), 2020 Aug 23; 12(8). PMID: 32823814    Free PMC article.
Review.
Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis.
Michitaka Matsuda, Ekihiro Seki.
Semin Liver Dis, 2020 Apr 04; 40(3). PMID: 32242330    Free PMC article.
Review.
Reciprocal Signaling between Myeloid Derived Suppressor and Tumor Cells Enhances Cellular Motility and is Mediated by Structural Cues in the Microenvironment.
Vasudha C Shukla, Silvia Duarte-Sanmiguel, +7 authors, Daniel Gallego-Perez.
Adv Biosyst, 2020 May 19; 4(6). PMID: 32419350    Free PMC article.
Interplay between immune cells in lung cancer: beyond T lymphocytes.
Juan-Manuel Hernandez-Martinez, Edgar Vergara, Edgar Montes-Servín, Oscar Arrieta.
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Circulating Plasmacytoid and Myeloid Dendritic Cells in Breast Cancer Patients: A Pilot Study.
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The Potential Role of Immune Alteration in the Cancer-COVID19 Equation-A Prospective Longitudinal Study.
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The Uncovered Role of Immune Cells and NK Cells in the Regulation of Bone Metastasis.
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Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme.
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High-throughput analysis of lung immune cells in a combined murine model of agriculture dust-triggered airway inflammation with rheumatoid arthritis.
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PLoS One, 2021 Feb 13; 16(2). PMID: 33577605    Free PMC article.
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Cell Immunol, 2021 Jan 22; 361. PMID: 33476931    Free PMC article.
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Nat Rev Drug Discov, 2021 Mar 10; 20(12). PMID: 33686237
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The Role of Regulatory Myeloid Cell Therapy in Renal Allograft Rejection.
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Front Immunol, 2021 Mar 16; 12. PMID: 33717141    Free PMC article.
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Front Immunol, 2021 Mar 20; 12. PMID: 33737934    Free PMC article.
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Targeting KRAS: The Elephant in the Room of Epithelial Cancers.
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Front Oncol, 2021 Mar 30; 11. PMID: 33777798    Free PMC article.
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Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment.
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Cell Mol Immunol, 2021 Apr 01; 18(5). PMID: 33785843    Free PMC article.
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Direct and Indirect Modulation of T Cells by VEGF-A Counteracted by Anti-Angiogenic Treatment.
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Recent advances in myeloid-derived suppressor cell biology.
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Front Med, 2020 Sep 03; 15(2). PMID: 32876877
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Human splenic myeloid derived suppressor cells: Phenotypic and clustering analysis.
Kathryn E Cole, Quan P Ly, +5 authors, James E Talmadge.
Cell Immunol, 2021 Mar 15; 363. PMID: 33714729    Free PMC article.
New Insights into the Multifaceted Role of Myeloid-Derived Suppressor Cells (MDSCs) in High-Grade Gliomas: From Metabolic Reprograming, Immunosuppression, and Therapeutic Resistance to Current Strategies for Targeting MDSCs.
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Cells, 2021 May 01; 10(4). PMID: 33919732    Free PMC article.
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Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis.
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Front Immunol, 2021 May 07; 12. PMID: 33953722    Free PMC article.
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Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer.
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miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells.
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Oncogene, 2020 Aug 29; 39(40). PMID: 32855524
Myelopoiesis during Solid Cancers and Strategies for Immunotherapy.
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Cells, 2021 May 01; 10(5). PMID: 33919157    Free PMC article.
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Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection.
Peter J Volberding, Gang Xin, +7 authors, Weiguo Cui.
Cell Rep, 2021 May 27; 35(8). PMID: 34038722    Free PMC article.
Targeting Natural Killer T Cells in Solid Malignancies.
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Immune-modulating Effect of Korean Red Ginseng by Balancing the Ratio of Peripheral T Lymphocytes in Bile Duct or Pancreatic Cancer Patients With Adjuvant Chemotherapy.
Im-Kyung Kim, Kang Young Lee, +2 authors, Joon Jeong.
In Vivo, 2021 Apr 30; 35(3). PMID: 33910879    Free PMC article.
MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer.
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J Clin Med, 2021 Jul 03; 10(13). PMID: 34203451    Free PMC article.
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Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer.
Natalia Palazón-Carrión, Carlos Jiménez-Cortegana, +9 authors, Spanish Breast Cancer Group (GEICAM) and the Spanish Group for Immunobiotherapy of Cancer (GÉTICA).
Sci Rep, 2021 Jul 15; 11(1). PMID: 34257359    Free PMC article.
Osteoclasts in Tumor Biology: Metastasis and Epithelial-Mesenchymal-Myeloid Transition.
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Pathol Oncol Res, 2021 Jul 15; 27. PMID: 34257573    Free PMC article.
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Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors.
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J Immunother Cancer, 2021 Jul 18; 9(7). PMID: 34272309    Free PMC article.
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CD73 expression in myeloid-derived suppressor cells is correlated with clinical stages in head and neck squamous cell carcinomas.
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Novel Characterization of Myeloid-Derived Suppressor Cells in Tumor Microenvironment.
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Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies.
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Inflammopharmacology, 2021 Oct 07; 29(6). PMID: 34613567
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Targeting of myeloid-derived suppressor cells by all-trans retinoic acid as host-directed therapy for human tuberculosis.
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Cell Immunol, 2021 Apr 18; 364. PMID: 33865151    Free PMC article.
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer.
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Increased Monocytic Myeloid-Derived Suppressor Cells in Whole Blood Predict Poor Prognosis in Patients with Plasma Cell Myeloma.
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J Clin Med, 2021 Oct 24; 10(20). PMID: 34682840    Free PMC article.
The Therapeutic Potential of Tackling Tumor-Induced Dendritic Cell Dysfunction in Colorectal Cancer.
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Front Immunol, 2021 Oct 26; 12. PMID: 34691029    Free PMC article.
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Age-related expansion and increased osteoclastogenic potential of myeloid-derived suppressor cells.
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Mol Immunol, 2021 Jul 19; 137. PMID: 34274794    Free PMC article.
A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells.
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iScience, 2021 Nov 27; 24(11). PMID: 34825135    Free PMC article.
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Innate Immun, 2013 Jun 13; 20(3). PMID: 23757323    Free PMC article.
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Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation.
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Head and Neck Squamous Cell Carcinoma: Risk Factors, Molecular Alterations, Immunology and Peptide Vaccines.
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MDSC: Markers, development, states, and unaddressed complexity.
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Immunotherapy Resistance in Glioblastoma.
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Front Genet, 2022 Jan 04; 12. PMID: 34976006    Free PMC article.
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Inflammation and Myeloid Cells in Cancer Progression and Metastasis.
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Front Cell Dev Biol, 2022 Feb 08; 9. PMID: 35127700    Free PMC article.
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Myeloid-derived suppressor cell infiltration is associated with a poor prognosis in patients with hepatocellular carcinoma.
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The Role of Myeloid-Derived Suppressor Cells in Tumor Growth and Metastasis.
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Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma.
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J Hematol Oncol, 2022 Feb 18; 15(1). PMID: 35172851    Free PMC article.
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A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources.
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Clin Epigenetics, 2022 Feb 23; 14(1). PMID: 35189960    Free PMC article.
Translocation of Helicobacter hepaticus synergizes with myeloid-derived suppressor cells and contributes to breast carcinogenesis.
Huan Deng, Sureshkumar Muthupalani, +4 authors, James G Fox.
Oncoimmunology, 2022 Apr 05; 11(1). PMID: 35371619    Free PMC article.
Splenic and PB immune recovery in neoadjuvant treated gastrointestinal cancer patients.
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Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases.
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Cells, 2022 Apr 13; 11(7). PMID: 35406754    Free PMC article.
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Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.
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Sci Transl Med, 2021 Dec 09; 13(623). PMID: 34878821    Free PMC article.
Neutrophil Functional Heterogeneity and Implications for Viral Infections and Treatments.
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Cells, 2022 Apr 24; 11(8). PMID: 35456003    Free PMC article.
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Pathological features of tissues and cell populations during cancer cachexia.
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