Journal Article
. 2001 Feb;19(4).
doi: 10.1200/JCO.2001.19.4.980.

Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer

P M Ravdin 1 L A Siminoff  G J Davis  M B Mercer  J Hewlett  N Gerson  H L Parker  
Affiliations
  • PMID: 11181660
  •     258 citations

Abstract

Purpose: The goal of the computer program Adjuvant! is to allow health professionals and their patients with early breast cancer to make more informed decisions about adjuvant therapy.

Methods: Actuarial analysis was used to project outcomes of patients with and without adjuvant therapy based on estimates of prognosis largely derived from Surveillance, Epidemiology, and End-Results data and estimates of the efficacy of adjuvant therapy based on the 1998 overviews of randomized trials of adjuvant therapy. These estimates can be refined using the Prognostic Factor Impact Calculator, which uses a Bayesian method to make adjustments based on relative risks conferred and prevalence of positive test results.

Results: From the entries of patient information (age, menopausal status, comorbidity estimate) and tumor staging and characteristics (tumor size, number of positive axillary nodes, estrogen receptor status), baseline prognostic estimates are made. Estimates for the efficacy of endocrine therapy (5 years of tamoxifen) and of polychemotherapy (cyclophosphamide/methotrexate/fluorouracil-like regimens, or anthracycline-based therapy, or therapy based on both an anthracycline and a taxane) can then be used to project outcomes presented in both numerical and graphical formats. Outcomes for overall survival and disease-free survival and the improvement seen in clinical trials, are reasonably modeled by Adjuvant!, although an ideal validation for all patient subsets with all treatment options is not possible. Additional speculative estimates of years of remaining life expectancy and long-term survival curves can also be produced. Help files supply general information about breast cancer. The program's Internet links supply national treatment guidelines, cooperative group trial options, and other related information.

Conclusion: The computer program Adjuvant! can play practical and educational roles in clinical settings.

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Ann Oncol, 2013 May 28; 24(9). PMID: 23709174    Free PMC article.
Multigene assays and molecular markers in breast cancer: systematic review of health economic analyses.
Roman Rouzier, Paolo Pronzato, +3 authors, William J Valentine.
Breast Cancer Res Treat, 2013 Jun 01; 139(3). PMID: 23722312    Free PMC article.
Systematic Review.
Toward better soft tissue sarcoma staging: building on american joint committee on cancer staging systems versions 6 and 7.
Robert G Maki, Nicole Moraco, +4 authors, Murray F Brennan.
Ann Surg Oncol, 2013 Jun 19; 20(11). PMID: 23775410    Free PMC article.
Association between genomic recurrence risk and well-being among breast cancer patients.
Valesca P Retèl, Catharina G M Groothuis-Oudshoorn, +3 authors, Wim H van Harten.
BMC Cancer, 2013 Jun 20; 13. PMID: 23777535    Free PMC article.
Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in oncology.
Charles Ferté, Andrew D Trister, +8 authors, Stephen H Friend.
Clin Cancer Res, 2013 Jun 20; 19(16). PMID: 23780890    Free PMC article.
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Luminal breast cancer: from biology to treatment.
Michail Ignatiadis, Christos Sotiriou.
Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035
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The value of personalised risk information: a qualitative study of the perceptions of patients with prostate cancer.
Paul K J Han, Norbert Hootsmans, +5 authors, Moritz Hansen.
BMJ Open, 2013 Sep 17; 3(9). PMID: 24038007    Free PMC article.
Clinicopathologic features of breast cancer patients with type 2 diabetes mellitus in southwest of China.
Rui-Jue Wang, Lin-Jie Lu, +5 authors, Ling-Quan Kong.
Med Oncol, 2013 Dec 18; 31(1). PMID: 24338167
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients.
Anna Tessari, Dario Palmieri, Serena Di Cosimo.
Pharmgenomics Pers Med, 2014 Jan 10; 7. PMID: 24403841    Free PMC article.
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The application of Oncotype DX in early-stage lymph-node-positive disease.
Sarika Jain, William J Gradishar.
Curr Oncol Rep, 2014 Jan 21; 16(1). PMID: 24442572
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Prognostic factors for survivals from first relapse in breast cancer patients: analysis of deceased patients.
Haeyoung Kim, Doo Ho Choi, +5 authors, Young-Hyuck Im.
Radiat Oncol J, 2014 Feb 07; 31(4). PMID: 24501710    Free PMC article.
A Majority of Low (1-10%) ER Positive Breast Cancers Behave Like Hormone Receptor Negative Tumors.
Jyothi S Prabhu, Aruna Korlimarla, +12 authors, T S Sridhar.
J Cancer, 2014 Feb 25; 5(2). PMID: 24563670    Free PMC article.
Good practice guidelines for biomarker discovery from array data: a case study for breast cancer prognosis.
Jie Cheng, Joel Greshock, +3 authors, Kwan Lee.
BMC Syst Biol, 2014 Feb 26; 7 Suppl 4. PMID: 24565120    Free PMC article.
Agreement on indication for systemic therapy between biopsied tissue and surgical excision specimens in breast cancer patients.
Alexander M Th Schmitz, Joost J Oudejans, Kenneth G A Gilhuijs.
PLoS One, 2014 Mar 13; 9(3). PMID: 24614128    Free PMC article.
Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer.
E A Rakha, D Soria, +6 authors, I O Ellis.
Br J Cancer, 2014 Mar 13; 110(7). PMID: 24619074    Free PMC article.
How much survival benefit is necessary for breast cancer patients to opt for adjuvant chemotherapy? Results from a Chilean survey.
Francisco Acevedo, Cesar Sanchez, +3 authors, Pelayo Besa.
Ecancermedicalscience, 2014 Mar 29; 8. PMID: 24678346    Free PMC article.
Clinical prediction rules in practice: review of clinical guidelines and survey of GPs.
Annette Plüddemann, Emma Wallace, +13 authors, Richard Stevens.
Br J Gen Pract, 2014 Apr 02; 64(621). PMID: 24686888    Free PMC article.
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Risk-scoring models for individualized prediction of overall survival in low-grade and high-grade endometrial cancer.
Mariam M AlHilli, Andrea Mariani, +6 authors, Karl C Podratz.
Gynecol Oncol, 2014 Apr 03; 133(3). PMID: 24690476    Free PMC article.
Predicting survival of de novo metastatic breast cancer in Asian women: systematic review and validation study.
Hui Miao, Mikael Hartman, +10 authors, Helena M Verkooijen.
PLoS One, 2014 Apr 04; 9(4). PMID: 24695692    Free PMC article.
Systematic Review.
Optimized outcome prediction in breast cancer by combining the 70-gene signature with clinical risk prediction algorithms.
C A Drukker, M V Nijenhuis, +10 authors, S C Linn.
Breast Cancer Res Treat, 2014 Apr 25; 145(3). PMID: 24760482    Free PMC article.
Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.
Noriko Nakamiya, Shigeto Ueda, +8 authors, Toshiaki Saeki.
Cancer Sci, 2014 Apr 29; 105(7). PMID: 24766271    Free PMC article.
Future directions for the early detection of colorectal cancer recurrence.
Avery S Walker, Eric K Johnson, +5 authors, Scott R Steele.
J Cancer, 2014 May 03; 5(4). PMID: 24790655    Free PMC article.
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Distinct clinicopathological features and prognosis of emerging young-female breast cancer in an East Asian country: a nationwide cancer registry-based study.
Ching-Hung Lin, Po-Ya Chuang, +7 authors, Chao-Hsiun Tang.
Oncologist, 2014 May 09; 19(6). PMID: 24807917    Free PMC article.
Integration of mRNA expression profile, copy number alterations, and microRNA expression levels in breast cancer to improve grade definition.
Claudia Cava, Gloria Bertoli, +5 authors, Isabella Castiglioni.
PLoS One, 2014 May 29; 9(5). PMID: 24866763    Free PMC article.
Molecular classification of breast cancer.
Darina Vuong, Peter T Simpson, +2 authors, Sunil R Lakhani.
Virchows Arch, 2014 Jun 01; 465(1). PMID: 24878755
Modern Risk Assessment for Individualizing Treatment Concepts in Early-stage Breast Cancer.
Alex Farr, Rachel Wuerstlein, +2 authors, Nadia Harbeck.
Rev Obstet Gynecol, 2013 Jan 01; 6(3-4). PMID: 24920978    Free PMC article.
Late recurrences in early breast cancer: for whom and how long is endocrine therapy beneficial?
Michael Knauer, Martin Filipits, Peter Dubsky.
Breast Care (Basel), 2014 Jun 20; 9(2). PMID: 24944551    Free PMC article.
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Organizing medical oncology care at a regional level and its subsequent impact on the quality of early breast cancer management: a before-after study.
Aline Voidey, Xavier Pivot, +4 authors, Samuel Limat.
BMC Health Serv Res, 2014 Jul 30; 14. PMID: 25070624    Free PMC article.
Measuring decision quality: psychometric evaluation of a new instrument for breast cancer chemotherapy.
Clara N Lee, Matthew H Wetschler, +4 authors, Karen R Sepucha.
BMC Med Inform Decis Mak, 2014 Aug 22; 14. PMID: 25142035    Free PMC article.
Serum metabolomic profiles evaluated after surgery may identify patients with oestrogen receptor negative early breast cancer at increased risk of disease recurrence. Results from a retrospective study.
Leonardo Tenori, Catherine Oakman, +8 authors, Angelo Di Leo.
Mol Oncol, 2014 Aug 26; 9(1). PMID: 25151299    Free PMC article.
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.
Hans Kristian Moen Vollan, Oscar M Rueda, +22 authors, Carlos Caldas.
Mol Oncol, 2014 Aug 30; 9(1). PMID: 25169931    Free PMC article.
A generic cycling hypoxia-derived prognostic gene signature: application to breast cancer profiling.
Romain Boidot, Samuel Branders, +3 authors, Olivier Feron.
Oncotarget, 2014 Sep 13; 5(16). PMID: 25216520    Free PMC article.
Update on adjuvant chemotherapy for early breast cancer.
Murtuza M Rampurwala, Gabrielle B Rocque, Mark E Burkard.
Breast Cancer (Auckl), 2014 Oct 23; 8. PMID: 25336961    Free PMC article.
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Effect of PREDICT on chemotherapy/trastuzumab recommendations in HER2-positive patients with early-stage breast cancer.
Sue K Down, Olivia Lucas, John R Benson, Gordon C Wishart.
Oncol Lett, 2014 Nov 05; 8(6). PMID: 25364461    Free PMC article.
Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients.
Gregory Weitsman, Katherine Lawler, +18 authors, Tony Ng.
Biochem Soc Trans, 2014 Nov 18; 42(6). PMID: 25399560    Free PMC article.
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Current treatment of early breast cancer: adjuvant and neoadjuvant therapy.
Elizabeth Miller, Hee Jin Lee, +3 authors, Bora Lim.
F1000Res, 2014 Nov 18; 3. PMID: 25400908    Free PMC article.
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A systematic literature review of life expectancy prediction tools for patients with localized prostate cancer.
Matthew Kent, Andrew J Vickers.
J Urol, 2014 Dec 03; 193(6). PMID: 25463998    Free PMC article.
Systematic Review.
Competing risks of death in younger and older postmenopausal breast cancer patients.
Judy-Anne W Chapman, Kathleen I Pritchard, +9 authors, Michael N Pollak.
World J Clin Oncol, 2014 Dec 11; 5(5). PMID: 25493245    Free PMC article.
Risk of marrow neoplasms after adjuvant breast cancer therapy: the national comprehensive cancer network experience.
Antonio C Wolff, Amanda L Blackford, +10 authors, Judith E Karp.
J Clin Oncol, 2014 Dec 24; 33(4). PMID: 25534386    Free PMC article.
Optimal management of breast cancer in the elderly patient: current perspectives.
Olivia Le Saux, Bertrand Ripamonti, +4 authors, Claire Falandry.
Clin Interv Aging, 2015 Jan 23; 10. PMID: 25609933    Free PMC article.
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Comparison of Nottingham Prognostic Index and Adjuvant Online prognostic tools in young women with breast cancer: review of a single-institution experience.
Benjamin Joseph Hearne, M Dawn Teare, Mohammad Butt, Leslie Donaldson.
BMJ Open, 2015 Jan 30; 5(1). PMID: 25628047    Free PMC article.
An evaluation of the prognostic model PREDICT using the POSH cohort of women aged ⩽40 years at breast cancer diagnosis.
T Maishman, E Copson, +7 authors, D Eccles.
Br J Cancer, 2015 Feb 13; 112(6). PMID: 25675148    Free PMC article.
The predictive accuracy of PREDICT: a personalized decision-making tool for Southeast Asian women with breast cancer.
Hoong-Seam Wong, Shridevi Subramaniam, +7 authors, Nirmala Bhoo-Pathy.
Medicine (Baltimore), 2015 Feb 26; 94(8). PMID: 25715267    Free PMC article.
The Nottingham Prognostic Index: five- and ten-year data for all-cause survival within a screened population.
Y Fong, J Evans, +3 authors, K Gower-Thomas.
Ann R Coll Surg Engl, 2015 Feb 28; 97(2). PMID: 25723691    Free PMC article.
Prone Versus Supine Breast FDG-PET/CT for Assessing Locoregional Disease Distribution in Locally Advanced Breast Cancer.
Richard G Abramson, Katrina F Lambert, +5 authors, Thomas E Yankeelov.
Acad Radiol, 2015 Apr 14; 22(7). PMID: 25865435    Free PMC article.
Development of individual survival estimating program for cancer patients' management.
Myung-Chul Chang.
Healthc Inform Res, 2015 May 23; 21(2). PMID: 25995966    Free PMC article.
E2F4 Program Is Predictive of Progression and Intravesical Immunotherapy Efficacy in Bladder Cancer.
Chao Cheng, Frederick S Varn, Carmen J Marsit.
Mol Cancer Res, 2015 Jun 03; 13(9). PMID: 26032289    Free PMC article.
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer.
Gloria Bertoli, Claudia Cava, Isabella Castiglioni.
Theranostics, 2015 Jul 23; 5(10). PMID: 26199650    Free PMC article.
Highly Cited. Review.
Association Between Phosphorylated Histone H3 and Oncotype DX Recurrence Scores in Breast Cancer.
Lik Hang Lee, Paul E Swanson, +2 authors, Hua Yang.
Appl Immunohistochem Mol Morphol, 2015 Sep 16; 25(1). PMID: 26371428    Free PMC article.
Identifying patients at high risk of breast cancer recurrence: strategies to improve patient outcomes.
Yehoda M Martei, Jennifer M Matro.
Breast Cancer (Dove Med Press), 2015 Oct 28; 7. PMID: 26504408    Free PMC article.
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Using a gene expression signature when controversy exists regarding the indication for adjuvant systemic treatment reduces the proportion of patients receiving adjuvant chemotherapy: a nationwide study.
A Kuijer, A C M van Bommel, +7 authors, Th van Dalen.
Genet Med, 2015 Nov 20; 18(7). PMID: 26583684
The Practicability of a Novel Prognostic Index (PI) Model and Comparison with Nottingham Prognostic Index (NPI) in Stage I-III Breast Cancer Patients Undergoing Surgical Treatment.
Jiahuai Wen, Feng Ye, +4 authors, Xiaoming Xie.
PLoS One, 2015 Nov 26; 10(11). PMID: 26600129    Free PMC article.
The Performance of the Nottingham Prognosis Index and the Adjuvant Online Decision Making Tool for Prognosis in Early-stage Breast Cancer Patients.
Mehri Rejali, Mehdi Tazhibi, +2 authors, Reyhane Mokarian.
Int J Prev Med, 2015 Nov 26; 6. PMID: 26605014    Free PMC article.
Biomarkers in Breast Cancer - An Update.
M Schmidt, P A Fasching, M W Beckmann, H Kölbl.
Geburtshilfe Frauenheilkd, 2012 Sep 01; 72(9). PMID: 26640290    Free PMC article.
Validity of the online PREDICT tool in older patients with breast cancer: a population-based study.
N A de Glas, E Bastiaannet, +6 authors, J E A Portielje.
Br J Cancer, 2016 Jan 20; 114(4). PMID: 26783995    Free PMC article.
Patterns in target-directed breast cancer research.
Sofia Torres, Christine Simmons, +3 authors, Maureen Trudeau.
Springerplus, 2016 Feb 16; 5. PMID: 26877907    Free PMC article.
Competing risks of death in women treated with adjuvant aromatase inhibitors for early breast cancer on NCIC CTG MA.27.
Judith-Anne W Chapman, Lois E Shepherd, +6 authors, Paul E Goss.
Breast Cancer Res Treat, 2016 Mar 24; 156(2). PMID: 27006189    Free PMC article.
Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer.
Srividya Vaidyanathan, Pulari U Thangavelu, Pascal H G Duijf.
Target Oncol, 2016 Mar 30; 11(5). PMID: 27023921
In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.
S Vaidyanathan, K Cato, +4 authors, P H G Duijf.
Oncogene, 2016 Apr 12; 35(41). PMID: 27065322
Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others.
John M S Bartlett, Jane Bayani, +18 authors, OPTIMA TMG.
J Natl Cancer Inst, 2016 May 01; 108(9). PMID: 27130929    Free PMC article.
Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium.
William J Howat, Fiona M Blows, +49 authors, Montserrat García-Closas.
J Pathol Clin Res, 2015 Jan 01; 1(1). PMID: 27499890    Free PMC article.
Multiparametric Genomic Assays for Breast Cancer: Time for the Next Generation?
Adam M Brufsky, Nancy E Davidson.
Clin Cancer Res, 2016 Aug 16; 22(20). PMID: 27521446    Free PMC article.
Adjuvant systemic therapy in older women with breast cancer.
Julieta Leone, Bernardo Amadeo Leone, José Pablo Leone.
Breast Cancer (Dove Med Press), 2016 Aug 16; 8. PMID: 27524919    Free PMC article.
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Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues.
Xiujie Chen, Lei Liu, +7 authors, Hongbo Xie.
Oncotarget, 2016 Aug 27; 8(13). PMID: 27564264    Free PMC article.
Prognostic models in male breast cancer.
Carmen C van der Pol, Miangela M Lacle, +7 authors, Paul J van Diest.
Breast Cancer Res Treat, 2016 Sep 28; 160(2). PMID: 27671991    Free PMC article.
Comparison of the Ability of Different Clinical Treatment Scores to Estimate Prognosis in High-Risk Early Breast Cancer Patients: A Hellenic Cooperative Oncology Group Study.
Flora Stavridi, Konstantine T Kalogeras, +19 authors, George Fountzilas.
PLoS One, 2016 Oct 04; 11(10). PMID: 27695115    Free PMC article.
Validation of the CancerMath prognostic tool for breast cancer in Southeast Asia.
Hui Miao, Mikael Hartman, +8 authors, Nirmala Bhoo-Pathy.
BMC Cancer, 2016 Oct 23; 16(1). PMID: 27769212    Free PMC article.
The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients.
Matteo Lambertini, Ana Catarina Pinto, +12 authors, Hatem A Azim.
Br J Cancer, 2016 Nov 02; 115(12). PMID: 27802449    Free PMC article.
Adjuvant chemotherapy and HER-2-directed therapy for early-stage breast cancer in the elderly.
J Sun, S Chia.
Br J Cancer, 2016 Nov 23; 116(1). PMID: 27875517    Free PMC article.
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In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion.
Pulari U Thangavelu, Tibor Krenács, Eloise Dray, Pascal H G Duijf.
Clin Epigenetics, 2016 Nov 29; 8. PMID: 27891193    Free PMC article.
Factors Influencing Decision-Making for or against Adjuvant and Neoadjuvant Chemotherapy in Postmenopausal Hormone Receptor-Positive Breast Cancer Patients in the EvAluate-TM Study.
Paul Gaß, Peter A Fasching, +47 authors, Christian R Löhberg.
Breast Care (Basel), 2016 Dec 07; 11(5). PMID: 27920623    Free PMC article.
Molecular Classification of Breast Carcinoma: From Traditional, Old-Fashioned Way to A New Age, and A New Way.
Nuket Eliyatkın, Evrim Yalçın, +2 authors, Enver Vardar.
J Breast Health, 2015 Jan 01; 11(2). PMID: 28331693    Free PMC article.
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Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65.
Suzanne C O'Neill, Claudine Isaacs, +8 authors, Arnold L Potosky.
Breast Cancer Res, 2017 Apr 01; 19(1). PMID: 28359319    Free PMC article.
Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance).
Jeanne S Mandelblatt, Ling Cai, +11 authors, Arti Hurria.
Breast Cancer Res Treat, 2017 Apr 02; 164(1). PMID: 28364214    Free PMC article.
Personalized Prognostic Prediction Models for Breast Cancer Recurrence and Survival Incorporating Multidimensional Data.
Xifeng Wu, Yuanqing Ye, +11 authors, Gabriel N Hortobagyi.
J Natl Cancer Inst, 2017 Apr 05; 109(7). PMID: 28376179    Free PMC article.
Clinical utility of gene-expression signatures in early stage breast cancer.
Maryann Kwa, Andreas Makris, Francisco J Esteva.
Nat Rev Clin Oncol, 2017 Jun 01; 14(10). PMID: 28561071
Highly Cited. Review.
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update.
Ian Krop, Nofisat Ismaila, +10 authors, Vered Stearns.
J Clin Oncol, 2017 Jul 12; 35(24). PMID: 28692382    Free PMC article.
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Internet tools to enhance breast cancer care.
Shlomit Strulov Shachar, Hyman B Muss.
NPJ Breast Cancer, 2016 Apr 27; 2. PMID: 28721377    Free PMC article.
Bridging the age gap in breast cancer: evaluation of decision support interventions for older women with operable breast cancer: protocol for a cluster randomised controlled trial.
Karen Collins, Malcolm Reed, +24 authors, Lynda Wyld.
BMJ Open, 2017 Aug 02; 7(7). PMID: 28760787    Free PMC article.
Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer?
Umar Wazir, Kinan Mokbel, Amtul Carmichael, Kefah Mokbel.
Cell Mol Biol Lett, 2017 Sep 08; 22. PMID: 28878809    Free PMC article.
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Preoperative indication for systemic therapy extended to patients with early-stage breast cancer using multiparametric 7-tesla breast MRI.
A M T Schmitz, W B Veldhuis, +8 authors, K G A Gilhuijs.
PLoS One, 2017 Sep 28; 12(9). PMID: 28949967    Free PMC article.
Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer.
Pulari U Thangavelu, Cheng-Yu Lin, +3 authors, Pascal H G Duijf.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977935    Free PMC article.
Development and validation of a nomogram predicting the overall survival of stage IV breast cancer patients.
Shunrong Li, Jianli Zhao, +2 authors, Kai Chen.
Cancer Med, 2017 Oct 06; 6(11). PMID: 28980424    Free PMC article.
Urine metabolomics as a predictor of patient tolerance and response to adjuvant chemotherapy in colorectal cancer.
Mark A Dykstra, Noah Switzer, +5 authors, Haili Wang.
Mol Clin Oncol, 2017 Nov 17; 7(5). PMID: 29142749    Free PMC article.
Large-scale DNA organization is a prognostic marker of breast cancer survival.
Martial Guillaud, Qian Ye, +5 authors, Mira Keyes.
Med Oncol, 2017 Dec 08; 35(1). PMID: 29214466
Prediction models for patients with esophageal or gastric cancer: A systematic review and meta-analysis.
H G van den Boorn, E G Engelhardt, +6 authors, H W M van Laarhoven.
PLoS One, 2018 Feb 09; 13(2). PMID: 29420636    Free PMC article.
Systematic Review.
Factors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort.
Alexandre Lafourcade, Mathilde His, +3 authors, Virginie Rondeau.
BMC Cancer, 2018 Feb 11; 18(1). PMID: 29426294    Free PMC article.
Spotlight on the utility of the Oncotype DX® breast cancer assay.
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Int J Womens Health, 2018 Mar 06; 10. PMID: 29503586    Free PMC article.
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Leukotriene Receptor Antagonists Inhibit Mitogenic Activity in Triple Negative Breast Cancer Cells
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Asian Pac J Cancer Prev, 2018 Mar 28; 19(3). PMID: 29582642    Free PMC article.
Cost-Effectiveness Analyses of the 21-Gene Assay in Breast Cancer: Systematic Review and Critical Appraisal.
Shi-Yi Wang, Weixiong Dang, +3 authors, Cary P Gross.
J Clin Oncol, 2018 Apr 17; 36(16). PMID: 29659329    Free PMC article.
Systematic Review.
Contralateral parenchymal enhancement on dynamic contrast-enhanced MRI reproduces as a biomarker of survival in ER-positive/HER2-negative breast cancer patients.
Bas H M van der Velden, Elizabeth J Sutton, +3 authors, Kenneth G A Gilhuijs.
Eur Radiol, 2018 May 08; 28(11). PMID: 29736850    Free PMC article.
Clinical decision making in cancer care: a review of current and future roles of patient age.
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BMC Cancer, 2018 May 11; 18(1). PMID: 29743048    Free PMC article.
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Identification of endothelial selectin as a potential prognostic marker in breast cancer.
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Oncol Lett, 2018 Jun 22; 15(6). PMID: 29928363    Free PMC article.
Impact of Micrometastatic Axillary Nodes on Survival of Breast Cancer Patients with Tumors ≤2 cm.
Hyeon Woo Bae, Kwang Hyun Yoon, +7 authors, Byeong-Woo Park.
World J Surg, 2018 Jul 01; 42(12). PMID: 29959491
Using Probability for Pathological Complete Response (pCR) as a Decision Support Marker for Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer Patients - a Survey Among Physicians.
Paul Gass, Michael Untch, +18 authors, Naiba Nabieva.
Geburtshilfe Frauenheilkd, 2018 Jul 31; 78(7). PMID: 30057427    Free PMC article.
Survival estimates stratified by the Nottingham Prognostic Index for early breast cancer: a systematic review and meta-analysis of observational studies.
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Systematic Review.
Development and validation of a new predictive model for breast cancer survival in New Zealand and comparison to the Nottingham prognostic index.
J Mark Elwood, Essa Tawfiq, +5 authors, Ross Lawrenson.
BMC Cancer, 2018 Sep 19; 18(1). PMID: 30223800    Free PMC article.
Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress.
Cheng-Yu Lin, Alexandra Beattie, +2 authors, Pascal H G Duijf.
Sci Rep, 2018 Sep 19; 8(1). PMID: 30224719    Free PMC article.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
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Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
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BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer.
Mi Jeong Kwon, Sae Byul Lee, +8 authors, Young Kee Shin.
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Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer.
Achim Wöckel, Michael P Lux, +17 authors, Hans-Christian Kolberg.
Geburtshilfe Frauenheilkd, 2018 Dec 01; 78(11). PMID: 30498278    Free PMC article.
Non-linear transformations of age at diagnosis, tumor size, and number of positive lymph nodes in prediction of clinical outcome in breast cancer.
Carina Forsare, Martin Bak, +8 authors, Mårten Fernö.
BMC Cancer, 2018 Dec 12; 18(1). PMID: 30526533    Free PMC article.
Web-Based Tool to Facilitate Shared Decision Making With Regard to Neoadjuvant Chemotherapy Use in Muscle-Invasive Bladder Cancer.
Matthew D Galsky, Michael Diefenbach, +12 authors, Bart S Ferket.
JCO Clin Cancer Inform, 2017 Nov 01; 1. PMID: 30657403    Free PMC article.
CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1-ErbB-PI3K signaling.
Hee-Joo Choi, Sora Jin, +12 authors, Gu Kong.
EMBO Rep, 2019 Aug 31; 20(10). PMID: 31468695    Free PMC article.
A Nomogram To Predict The Overall Survival Of Breast Cancer Patients And Guide The Postoperative Adjuvant Chemotherapy In China.
Xin Wang, Ziwei Feng, +12 authors, Kexin Chen.
Cancer Manag Res, 2019 Dec 11; 11. PMID: 31819635    Free PMC article.
Chemotherapy effectiveness in trial-underrepresented groups with early breast cancer: A retrospective cohort study.
Ewan Gray, Joachim Marti, +3 authors, SATURNE advisory group.
PLoS Med, 2020 Jan 01; 16(12). PMID: 31891574    Free PMC article.
Clinicopathologic analysis of 722 breast cancer patients who met the inclusion criteria of the TAILORx trial.
Hong-Yu Xiang, Yin-Hua Liu, +7 authors, Qian Liu.
Chin Med J (Engl), 2019 Dec 07; 132(24). PMID: 31809316    Free PMC article.
miRNAs and Long-term Breast Cancer Survival: Evidence from the WHEL Study.
Loki Natarajan, Minya Pu, +10 authors, Karen Messer.
Cancer Epidemiol Biomarkers Prev, 2019 Jun 13; 28(9). PMID: 31186261    Free PMC article.
A conditional model predicting the 10-year annual extra mortality risk compared to the general population: a large population-based study in Dutch breast cancer patients.
Marissa C van Maaren, Robert F Kneepkens, +4 authors, Sabine Siesling.
PLoS One, 2019 Jan 25; 14(1). PMID: 30677053    Free PMC article.
Facilitating validation of prediction models: a comparison of manual and semi-automated validation using registry-based data of breast cancer patients in the Netherlands.
Cornelia D van Steenbeek, Marissa C van Maaren, +3 authors, Hendrik Koffijberg.
BMC Med Res Methodol, 2019 Jun 10; 19(1). PMID: 31176362    Free PMC article.
Clinical Decision Support Systems in Breast Cancer: A Systematic Review.
Claudia Mazo, Cathriona Kearns, Catherine Mooney, William M Gallagher.
Cancers (Basel), 2020 Feb 12; 12(2). PMID: 32041094    Free PMC article.
Review.
Incorporation of clinical and biological factors improves prognostication and reflects contemporary clinical practice.
Rashmi K Murthy, Juhee Song, +8 authors, Gabriel N Hortobagyi.
NPJ Breast Cancer, 2020 Mar 29; 6. PMID: 32219153    Free PMC article.
Review.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
"Radiotherapy for older women (ROW)": A risk calculator for women with early-stage breast cancer.
Shi-Yi Wang, Fuad Abujarad, +5 authors, Cary P Gross.
J Geriatr Oncol, 2020 Jan 04; 11(5). PMID: 31899199    Free PMC article.
Patients' perceptions of 70-gene signature testing: commonly changing the initial inclination to undergo or forego chemotherapy and reducing decisional conflict.
Julia E C van Steenhoven, Bianca M den Dekker, +6 authors, Thijs van Dalen.
Breast Cancer Res Treat, 2020 May 21; 182(1). PMID: 32430679    Free PMC article.
Nomogram Identifies Age as the Most Important Predictor of Overall Survival in Oral Cavity Squamous Cell Cancer After Primary Surgery.
Supriya Gupta, Jennifer Waller, +3 authors, Darko Pucar.
Indian J Otolaryngol Head Neck Surg, 2020 Jun 20; 72(2). PMID: 32551272    Free PMC article.
A Value of Information Analysis of Research on the 21-Gene Assay for Breast Cancer Management.
Natalia R Kunst, Fernando Alarid-Escudero, A David Paltiel, Shi-Yi Wang.
Value Health, 2019 Sep 30; 22(10). PMID: 31563252    Free PMC article.
Management of hormone receptor-positive, HER2-negative early breast cancer.
Elaine M Walsh, Karen L Smith, Vered Stearns.
Semin Oncol, 2020 Jun 18; 47(4). PMID: 32546323    Free PMC article.
Review.
Methodology of a Novel Risk Stratification Algorithm for Patients with Multiple Myeloma in the Relapsed Setting.
Walter Bouwmeester, Andrew Briggs, +5 authors, Lucie Brozova.
Oncol Ther, 2020 Jul 24; 7(2). PMID: 32699987    Free PMC article.
The Potential Use of Tumour-Based Prognostic and Predictive Tools in Older Women with Primary Breast Cancer: A Narrative Review.
Sophie Gordon-Craig, Ruth M Parks, Kwok-Leung Cheung.
Oncol Ther, 2020 Jul 24; 8(2). PMID: 32700048    Free PMC article.
Review.
Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation.
Simon J Johnston, Kwok-Leung Cheung.
Oncol Ther, 2018 Dec 01; 6(2). PMID: 32700026    Free PMC article.
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Winter is over: The use of Artificial Intelligence to individualise radiation therapy for breast cancer.
Philip M P Poortmans, Silvia Takanen, +2 authors, Orit Kaidar-Person.
Breast, 2020 Jan 14; 49. PMID: 31931265    Free PMC article.
A system for risk stratification and prioritization of breast cancer surgeries delayed by the COVID-19 pandemic: preparing for re-entry.
Barbara L Smith, Anvy Nguyen, +6 authors, Michele A Gadd.
Breast Cancer Res Treat, 2020 Jul 28; 183(3). PMID: 32712878    Free PMC article.
Review.
A Comparison Between the Online Prediction Models CancerMath and PREDICT as Prognostic Tools in Thai Breast Cancer Patients.
Nuanphan Polchai, Doonyapat Sa-Nguanraksa, +3 authors, Pornchai O-Charoenrat.
Cancer Manag Res, 2020 Aug 06; 12. PMID: 32753968    Free PMC article.
Propensity score analysis of the prognostic value of genomic assays for breast cancer in diverse populations using the National Cancer Data Base.
Abiola Ibraheem, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2020 Jun 11; 126(17). PMID: 32521056    Free PMC article.
Development and validation of a nomogram for predicting survival of advanced breast cancer patients in China.
Shaoyan Lin, Hongnan Mo, +14 authors, Binghe Xu.
Breast, 2020 Aug 25; 53. PMID: 32836201    Free PMC article.
Is There a Relationship between Shared Decision Making and Breast Cancer Patients' Trust in Their Medical Oncologists?
Ellen G Engelhardt, Ellen M A Smets, +3 authors, Marij A Hillen.
Med Decis Making, 2019 Dec 04; 40(1). PMID: 31789100    Free PMC article.
Biology of Oestrogen-Receptor Positive Primary Breast Cancer in Older Women with Utilisation of Core Needle Biopsy Samples and Correlation with Clinical Outcome.
Ruth M Parks, Mohammad Albanghali, +3 authors, Kwok-Leung Cheung.
Cancers (Basel), 2020 Jul 31; 12(8). PMID: 32726924    Free PMC article.
Development of a Ten-lncRNA Signature Prognostic Model for Breast Cancer Survival: A Study with the TCGA Database.
Wenqing Zhou, Yongkui Pang, Yunmin Yao, Huiying Qiao.
Anal Cell Pathol (Amst), 2020 Sep 11; 2020. PMID: 32908814    Free PMC article.
Stage II-III colon cancer: a comparison of survival calculators.
Riccardo Lemini, Kristopher Attwood, +5 authors, Emmanuel Gabriel.
J Gastrointest Oncol, 2019 Jan 04; 9(6). PMID: 30603128    Free PMC article.
SOURCE: A Registry-Based Prediction Model for Overall Survival in Patients with Metastatic Oesophageal or Gastric Cancer.
Héctor G van den Boorn, Ameen Abu-Hanna, +15 authors, Hanneke W M van Laarhoven.
Cancers (Basel), 2019 Feb 16; 11(2). PMID: 30764578    Free PMC article.
Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis.
Alicja Trebinska-Stryjewska, Lukasz Szafron, +7 authors, Ewa A Grzybowska.
J Oncol, 2019 May 17; 2019. PMID: 31093284    Free PMC article.
Young-onset breast cancer: a poor prognosis only exists in low-risk patients.
Jianfei Fu, Lunpo Wu, +7 authors, Jinlin Du.
J Cancer, 2019 Jul 11; 10(14). PMID: 31289582    Free PMC article.
Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences.
Ana Tablante Nunes, Deborah E Collyar, Lyndsay N Harris.
JNCI Cancer Spectr, 2017 Dec 11; 1(1). PMID: 31360834    Free PMC article.
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TRIPOD statement: a preliminary pre-post analysis of reporting and methods of prediction models.
Amir H Zamanipoor Najafabadi, Chava L Ramspek, +7 authors, Merel van Diepen.
BMJ Open, 2020 Sep 20; 10(9). PMID: 32948578    Free PMC article.
A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study.
Wen Zhao, Lei Wu, +11 authors, Jin Yang.
BMC Cancer, 2020 Oct 14; 20(1). PMID: 33046035    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial.
Ian Smith, John Robertson, +16 authors, Mitch Dowsett.
Lancet Oncol, 2020 Nov 06; 21(11). PMID: 33152284    Free PMC article.
Nomogram-derived prediction of pathologic complete response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy (NCT).
Shengyu Pu, Ke Wang, +4 authors, Jian Zhang.
BMC Cancer, 2020 Nov 21; 20(1). PMID: 33213397    Free PMC article.
Multidimensional Machine Learning Personalized Prognostic Model in an Early Invasive Breast Cancer Population-Based Cohort in China: Algorithm Validation Study.
Xiaorong Zhong, Ting Luo, +13 authors, Hong Zheng.
JMIR Med Inform, 2020 Nov 10; 8(11). PMID: 33164899    Free PMC article.
The overall survival of breast cancer patients without adjuvant therapy.
Sakura Onishi, Masataka Sawaki, +11 authors, Hiroji Iwata.
Surg Today, 2019 Feb 08; 49(7). PMID: 30730005
Prognostic models for breast cancer: a systematic review.
Minh Tung Phung, Sandar Tin Tin, J Mark Elwood.
BMC Cancer, 2019 Mar 16; 19(1). PMID: 30871490    Free PMC article.
Systematic Review.
Communicating prognosis to women with early breast cancer - overview of prediction tools and the development and pilot testing of a decision aid.
Viktoria Mühlbauer, Birte Berger-Höger, +2 authors, Anke Steckelberg.
BMC Health Serv Res, 2019 Mar 17; 19(1). PMID: 30876414    Free PMC article.
Systematic Review.
Development and validation of nomograms predicting survival in Chinese patients with triple negative breast cancer.
Yaping Yang, Ying Wang, +7 authors, Jieqiong Liu.
BMC Cancer, 2019 Jun 07; 19(1). PMID: 31170946    Free PMC article.
Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients.
Gangqin Xi, Wenhui Guo, +16 authors, Jianxin Chen.
Theranostics, 2021 Feb 05; 11(7). PMID: 33537084    Free PMC article.
Concordance between results of inexpensive statistical models and multigene signatures in patients with ER+/HER2- early breast cancer.
Laurence Slembrouck, Isabelle Vanden Bempt, +12 authors, Giuseppe Floris.
Mod Pathol, 2021 Feb 10;. PMID: 33558657

;. PMID: 33574250
Recommendations from the European Commission Initiative on Breast Cancer for multigene testing to guide the use of adjuvant chemotherapy in patients with early breast cancer, hormone receptor positive, HER-2 negative.
Paolo Giorgi Rossi, Annette Lebeau, +13 authors, ECIBC Contributor Group.
Br J Cancer, 2021 Feb 19;. PMID: 33597715
Review.
A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling.
Ainhoa Arana Echarri, Mark Beresford, +6 authors, James E Turner.
Front Immunol, 2021 Feb 19; 11. PMID: 33597950    Free PMC article.
Review.