Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

H Nishimura ¹, T Okazaki , Y Tanaka , K Nakatani , M Hara , A Matsumori , S Sasayama , A Mizoguchi , H Hiai , N Minato , T Honjo

Affiliations

¹ Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo, Kyoto, 606-8501, Japan.

PMID: 11209085
629 citations

Abstract

Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mice, but not in BALB/c RAG-2-/- mice, caused dilated cardiomyopathy with severely impaired contraction and sudden death by congestive heart failure. Affected hearts showed diffuse deposition of immunoglobulin G (IgG) on the surface of cardiomyocytes. All of the affected PD-1-/- mice exhibited high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes. These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.

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PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine. Jacalyn Rosenblatt, Brett Glotzbecker, +10 authors, David Avigan. less J Immunother, 2011 May 18; 34(5). PMID: 21577144 Free PMC article. Highly Cited.
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice. Hongmei Peng, Xiao-Ping Yang, +8 authors, Nour-Eddine Rhaleb. less Exp Physiol, 2011 May 24; 96(8). PMID: 21602297 Free PMC article.
Costimulatory pathways in transplantation. Nina Pilat, Mohamed H Sayegh, Thomas Wekerle. Semin Immunol, 2011 May 28; 23(4). PMID: 21616680 Free PMC article.
cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells. Petra Verdino, Deborah A Witherden, +3 authors, Ian A Wilson. less PLoS One, 2011 Jun 02; 6(5). PMID: 21629689 Free PMC article.
Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients. Tao Shen, Jiajia Zheng, +5 authors, Fengmin Lu. less Virol J, 2011 Jun 08; 8. PMID: 21645420 Free PMC article.
Prostate cancer immunotherapy. Kenneth F May, James L Gulley, +2 authors, Charles G Drake, Glenn Dranoff, Philip W Kantoff. less Clin Cancer Res, 2011 Jun 28; 17(16). PMID: 21700764 Free PMC article.
Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets. Chuanwu Wang, Peter Hillsamer, Chang H Kim. BMC Immunol, 2011 Sep 15; 12. PMID: 21914188 Free PMC article.
Role of immunotherapy for renal cell cancer in 2011. Saby George, Roberto Pili, Michael A Carducci, Jenny J Kim. J Natl Compr Canc Netw, 2011 Sep 16; 9(9). PMID: 21917625 Free PMC article. Review.
Beyond cancer vaccines: a reason for future optimism with immunomodulatory therapy. Michael Postow, Margaret K Callahan, Jedd D Wolchok. Cancer J, 2011 Sep 29; 17(5). PMID: 21952288 Free PMC article. Review.
The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. Kimberly A Hofmeyer, Hyungjun Jeon, Xingxing Zang. J Biomed Biotechnol, 2011 Oct 01; 2011. PMID: 21960736 Free PMC article. Review.
Programmed cell death 1 suppresses B-1b cell expansion and long-lived IgG production in response to T cell-independent type 2 antigens. Karen M Haas. J Immunol, 2011 Oct 18; 187(10). PMID: 22003198 Free PMC article.
Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population. Qianli Meng, Haike Guo, +3 authors, Peizeng Yang. less PLoS One, 2011 Nov 01; 6(10). PMID: 22039410 Free PMC article.
Genes, tolerance and systemic autoimmunity. Ram P Singh, Richard T Waldron, Bevra H Hahn. Autoimmun Rev, 2011 Dec 14; 11(9). PMID: 22155015 Free PMC article. Review.
Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy. Dallas B Flies, Britt J Sandler, Mario Sznol, Lieping Chen. Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180678 Free PMC article. Review.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali. less Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141 Free PMC article. Highly Cited.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors. Oana Draghiciu, Hans W Nijman, Toos Daemen. Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971 Free PMC article. Review.
Cancer immunotherapy comes of age. Ira Mellman, George Coukos, Glenn Dranoff. Nature, 2011 Dec 24; 480(7378). PMID: 22193102 Free PMC article. Highly Cited. Review.
Role of PD-1 in HIV pathogenesis and as target for therapy. Filippos Porichis, Daniel E Kaufmann. Curr HIV/AIDS Rep, 2011 Dec 27; 9(1). PMID: 22198819 Free PMC article. Review.
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. Julius Clemence R Hafalla, Carla Claser, +4 authors, Eleanor M Riley. less PLoS Pathog, 2012 Feb 10; 8(2). PMID: 22319445 Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy. Drew Pardoll, Charles Drake. J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682 Free PMC article.
BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis. Yoshio Sugino, Nobuyuki Nishikawa, +6 authors, Osamu Ogawa. less Sci Rep, 2012 Mar 21; 2. PMID: 22432050 Free PMC article.
The blockade of immune checkpoints in cancer immunotherapy. Drew M Pardoll. Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870 Free PMC article. Highly Cited. Review.
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma. Michael A Postow, James Harding, Jedd D Wolchok. Cancer J, 2012 Mar 29; 18(2). PMID: 22453017 Free PMC article. Review.
Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism. Guilin Qiao, Lifen Yang, +4 authors, Jian Zhang. less Clin Immunol, 2012 Mar 31; 143(2). PMID: 22459706 Free PMC article.
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Janis M Taube, Robert A Anders, +8 authors, Lieping Chen. less Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461641 Free PMC article. Highly Cited.
PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis. Margarite L Tarrio, Nir Grabie, +2 authors, De-xiu Bu, Arlene H Sharpe, Andrew H Lichtman. less J Immunol, 2012 Apr 12; 188(10). PMID: 22491251 Free PMC article.
Positive and negative regulation of cellular immune responses in physiologic conditions and diseases. S Viganò, M Perreau, G Pantaleo, A Harari. Clin Dev Immunol, 2012 May 02; 2012. PMID: 22548114 Free PMC article. Review.
Immunotherapy of cancer in 2012. John M Kirkwood, Lisa H Butterfield, +3 authors, Soldano Ferrone. less CA Cancer J Clin, 2012 May 12; 62(5). PMID: 22576456 Free PMC article. Highly Cited. Review.
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. Tadashi Yokosuka, Masako Takamatsu, +3 authors, Takashi Saito. less J Exp Med, 2012 May 30; 209(6). PMID: 22641383 Free PMC article. Highly Cited.
Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms. Sivan Sapoznik, Ohad Hammer, +4 authors, Gal Markel. less Clin Dev Immunol, 2012 Jul 11; 2012. PMID: 22778766 Free PMC article. Review.
Immunoregulatory molecules are master regulators of inflammation during the immune response. Hortensia de la Fuente, Danay Cibrián, Francisco Sánchez-Madrid. FEBS Lett, 2012 Jul 24; 586(18). PMID: 22819828 Free PMC article. Review.
Immunotherapy for prostate cancer enters its golden age. Sosipatros A Boikos, Emmanuel S Antonarakis. Clin Med Insights Oncol, 2012 Jul 31; 6. PMID: 22844202 Free PMC article.
Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy. Zhi-Chun Ding, Lei Huang, +4 authors, Gang Zhou. less Blood, 2012 Aug 04; 120(11). PMID: 22859605 Free PMC article.
Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-on-chronic liver failure. Dayan Cao, Huan Xu, +5 authors, Yongwen Chen. less Inflammation, 2012 Aug 17; 36(1). PMID: 22895698
Role of the PD-1 pathway in the immune response. L V Riella, A M Paterson, A H Sharpe, A Chandraker. Am J Transplant, 2012 Aug 21; 12(10). PMID: 22900886 Free PMC article. Highly Cited. Review.
Coinhibitory molecules in autoimmune diseases. Norihiko Watanabe, Hiroshi Nakajima. Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525 Free PMC article. Review.
T-cell inhibitors: a bench-to-bedside review. Shinjita Das, Kiyoshi Ariizumi, Ponciano D Cruz. Dermatitis, 2012 Sep 27; 23(5). PMID: 23010825 Free PMC article. Review.
Advances in the development of cancer immunotherapies. Jianjun Gao, Chantale Bernatchez, +2 authors, Padmanee Sharma, Laszlo G Radvanyi, Patrick Hwu. less Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830 Free PMC article. Review.
Lessons learned from experimental myocarditis. A Matsumori. Herz, 2012 Oct 25; 37(8). PMID: 23092967
The DC-HIL ligand syndecan-4 is a negative regulator of T-cell allo-reactivity responsible for graft-versus-host disease. Jin-Sung Chung, Mizuki Tomihari, +3 authors, Kiyoshi Ariizumi. less Immunology, 2012 Nov 02; 138(2). PMID: 23113638 Free PMC article.
Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management. Alida L P Caforio, Renzo Marcolongo, +3 authors, S Iliceto. less Heart Fail Rev, 2012 Nov 02; 18(6). PMID: 23114995 Review.
Costimulation blockade: current perspectives and implications for therapy. Gillian Kinnear, Nick D Jones, Kathryn J Wood. Transplantation, 2012 Nov 07; 95(4). PMID: 23129000 Free PMC article. Review.
Immunology beats cancer: a blueprint for successful translation. Drew M Pardoll. Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205 Free PMC article.
Immunotherapies: the blockade of inhibitory signals. Yan-Ling Wu, Jing Liang, +2 authors, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama. less Int J Biol Sci, 2012 Dec 01; 8(10). PMID: 23197939 Free PMC article. Review.
Immune tolerance and transplantation. Onder Alpdogan, Marcel R M van den Brink. Semin Oncol, 2012 Dec 05; 39(6). PMID: 23206840 Free PMC article. Review.
Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice. Helge Frebel, Veronika Nindl, +8 authors, Annette Oxenius. less J Exp Med, 2012 Dec 12; 209(13). PMID: 23230000 Free PMC article. Highly Cited.
Demystifying immunotherapy in prostate cancer: understanding current and future treatment strategies. Ravi A Madan, James L Gulley, Philip W Kantoff. Cancer J, 2013 Jan 23; 19(1). PMID: 23337757 Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation. Sheng Yao, Yuwen Zhu, Lieping Chen. Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250 Free PMC article. Highly Cited. Review.
SHP-1 phosphatase activity counteracts increased T cell receptor affinity. Michael Hebeisen, Lukas Baitsch, +5 authors, Nathalie Rufer. less J Clin Invest, 2013 Feb 09; 123(3). PMID: 23391724 Free PMC article.
Structure and interactions of the human programmed cell death 1 receptor. Xiaoxiao Cheng, Vaclav Veverka, +16 authors, Simon J Davis. less J Biol Chem, 2013 Feb 19; 288(17). PMID: 23417675 Free PMC article. Highly Cited.
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Richard S Hotchkiss, Guillaume Monneret, Didier Payen. Lancet Infect Dis, 2013 Feb 23; 13(3). PMID: 23427891 Free PMC article. Highly Cited. Review.
The nature of activatory and tolerogenic dendritic cell-derived signal II. Ghaith Bakdash, Simone P Sittig, +2 authors, Tjeerd van Dijk, Carl G Figdor, I Jolanda M de Vries. less Front Immunol, 2013 Mar 02; 4. PMID: 23450201 Free PMC article.
Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer. Mario Sznol, Lieping Chen. Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460533 Free PMC article. Highly Cited.
The role of B-cells in heart failure. Andrea M Cordero-Reyes, Keith A Youker, Guillermo Torre-Amione. Methodist Debakey Cardiovasc J, 2013 Mar 23; 9(1). PMID: 23519014 Free PMC article. Review.
Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells. Mario Hubo, Bettina Trinschek, +3 authors, Helmut Jonuleit. less Front Immunol, 2013 Apr 09; 4. PMID: 23565116 Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. Andrew M Intlekofer, Craig B Thompson. J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198 Free PMC article. Highly Cited. Review.
Genomics of vasculitis: lessons from mouse models. Masato Nose, Hiroaki Komori, Tatsuhiko Miyazaki, Shiro Mori. Ann Vasc Dis, 2013 May 04; 6(1). PMID: 23641278 Free PMC article.
PD-1 regulates T cell proliferation in a tissue and subset-specific manner during normal mouse pregnancy. Michelle T Shepard, Elizabeth A Bonney. Immunol Invest, 2013 Jun 21; 42(5). PMID: 23782245 Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer. Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer. less Front Immunol, 2013 Jun 27; 4. PMID: 23801991 Free PMC article.
The heart of the matter: protection of the myocardium from T cells. Andrew H Lichtman. J Autoimmun, 2013 Jul 03; 45. PMID: 23810579 Free PMC article. Review.
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Christopher J Nirschl, Charles G Drake. Clin Cancer Res, 2013 Jul 23; 19(18). PMID: 23868869 Free PMC article. Highly Cited. Review.
Dilated cardiomyopathy update: infectious-immune theory revisited. Chuichi Kawai, Akira Matsumori. Heart Fail Rev, 2013 Jul 31; 18(6). PMID: 23892949 Review.
B7 family checkpoint regulators in immune regulation and disease. Sabrina Ceeraz, Elizabeth C Nowak, Randolph J Noelle. Trends Immunol, 2013 Aug 21; 34(11). PMID: 23954143 Free PMC article. Highly Cited. Review.
The role of interleukin-6 in the expression of PD-1 and PDL-1 on central nervous system cells following infection with Theiler's murine encephalomyelitis virus. Young-Hee Jin, Wanqiu Hou, +2 authors, Hyun Seok Kang, Chang-Sung Koh, Byung S Kim. less J Virol, 2013 Aug 24; 87(21). PMID: 23966393 Free PMC article.
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response. Yuxiang Rui, Tasuku Honjo, Shunsuke Chikuma. Proc Natl Acad Sci U S A, 2013 Sep 18; 110(40). PMID: 24043779 Free PMC article.
Expression of programmed death-1 (PD-1) on CD4+ and CD8+ T cells in rheumatoid arthritis. Shufeng Li, Wensheng Liao, +5 authors, Zhen Yuan. less Inflammation, 2013 Sep 26; 37(1). PMID: 24062057
Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma. D Atanackovic, T Luetkens, N Kröger. Leukemia, 2013 Oct 25; 28(5). PMID: 24153012 Review.
PD-1 modulates steady-state and infection-induced IL-10 production in vivo. Cortez McBerry, Alexandra Dias, +5 authors, Julio Aliberti. less Eur J Immunol, 2013 Oct 30; 44(2). PMID: 24165808 Free PMC article.
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis. Katherine Chang, Catherine Svabek, +11 authors, Richard Hotchkiss. less Crit Care, 2014 Jan 07; 18(1). PMID: 24387680 Free PMC article. Highly Cited.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander". Lucia Gelao, Carmen Criscitiello, +2 authors, Angela Esposito, Aron Goldhirsch, Giuseppe Curigliano. less Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636 Free PMC article. Review.
Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy. Maxine Bauzon, Terry Hermiston. Front Immunol, 2014 Mar 08; 5. PMID: 24605114 Free PMC article. Review.
Immune and genetic gardening of the intestinal microbiome. Jonathan P Jacobs, Jonathan Braun. FEBS Lett, 2014 Mar 13; 588(22). PMID: 24613921 Free PMC article. Review.
Fallen angels or risen apes? A tale of the intricate complexities of imbalanced immune responses in the pathogenesis and progression of immune-mediated and viral cancers. Beatrice Omusiro Ondondo. Front Immunol, 2014 Mar 19; 5. PMID: 24639678 Free PMC article. Review.
Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications. Zhixue Zheng, Zhaode Bu, +10 authors, Jiafu Ji. less Chin J Cancer Res, 2014 Mar 22; 26(1). PMID: 24653632 Free PMC article.
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg. less J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641 Free PMC article. Highly Cited.
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Janis M Taube, Alison Klein, +7 authors, Robert A Anders. less Clin Cancer Res, 2014 Apr 10; 20(19). PMID: 24714771 Free PMC article. Highly Cited.
VSIG4 expression on macrophages facilitates lung cancer development. Yunmei Liao, Sheng Guo, +6 authors, Zhihua Ruan. less Lab Invest, 2014 May 28; 94(7). PMID: 24862966
Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes. Naoko Okiyama, Stephen I Katz. J Autoimmun, 2014 Jul 23; 53. PMID: 25047812 Free PMC article.
PD-1 as an immune modulatory receptor. Sheng Yao, Lieping Chen. Cancer J, 2014 Aug 08; 20(4). PMID: 25098286 Free PMC article. Review.
Biochemical signaling of PD-1 on T cells and its functional implications. Vassiliki A Boussiotis, Pranam Chatterjee, Lequn Li. Cancer J, 2014 Aug 08; 20(4). PMID: 25098287 Free PMC article. Review.
PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence. Scott S Tykodi. Onco Targets Ther, 2014 Aug 13; 7. PMID: 25114573 Free PMC article. Review.
Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus. Steve P Crampton, Peter A Morawski, Silvia Bolland. Dis Model Mech, 2014 Aug 26; 7(9). PMID: 25147296 Free PMC article. Review.
Regulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological Disorders. Shangfeng Zhao, Fengwu Li, +2 authors, Rehana K Leak, Jun Chen, Xiaoming Hu. less Front Cell Neurosci, 2014 Sep 19; 8. PMID: 25232304 Free PMC article. Review.
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. Li Wang, Isabelle Le Mercier, +7 authors, Randolph J Noelle. less Proc Natl Acad Sci U S A, 2014 Oct 01; 111(41). PMID: 25267631 Free PMC article.
Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE). Wei Jiang, Gary Gilkeson. J Immunother Appl, 2014 Oct 14; 1. PMID: 25309746 Free PMC article.
[Advances of PD-1/PD-L1 signaling pathway in immune escape and treatment for  non-small cell lung cancer]. Cheng Lin, Xiong Chen, +2 authors, Jingnan Liu, Yufang Huang, Xuenong Ou-Yang. less Zhongguo Fei Ai Za Zhi, 2014 Oct 25; 17(10). PMID: 25342040 Free PMC article. Review.
Myeloid-derived suppressor cells impair alveolar macrophages through PD-1 receptor ligation during Pneumocystis pneumonia. Guang-Sheng Lei, Chen Zhang, Chao-Hung Lee. Infect Immun, 2014 Nov 19; 83(2). PMID: 25404033 Free PMC article.
Clinical blockade of PD1 and LAG3--potential mechanisms of action. Linh T Nguyen, Pamela S Ohashi. Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622 Highly Cited. Review.
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo. Rituparna Das, Rakesh Verma, +8 authors, Kavita M Dhodapkar. less J Immunol, 2014 Dec 30; 194(3). PMID: 25539810 Free PMC article. Highly Cited.
Anti-programmed death receptor 1 immunotherapy in melanoma: rationale, evidence and clinical potential. Morganna Freeman-Keller, Jeffrey S Weber. Ther Adv Med Oncol, 2015 Jan 02; 7(1). PMID: 25553080 Free PMC article. Review.
Immune Checkpoint Blockade in Cancer Therapy. Michael A Postow, Margaret K Callahan, Jedd D Wolchok. J Clin Oncol, 2015 Jan 22; 33(17). PMID: 25605845 Free PMC article. Highly Cited. Review.
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma. Rafael Winograd, Katelyn T Byrne, +8 authors, Robert H Vonderheide. less Cancer Immunol Res, 2015 Feb 14; 3(4). PMID: 25678581 Free PMC article. Highly Cited.
Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes. R Fujisawa, F Haseda, +8 authors, T Hanafusa. less Clin Exp Immunol, 2015 Feb 17; 180(3). PMID: 25682896 Free PMC article.
Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis. Lin Cheng, Xian Tang, +13 authors, Zhiwei Chen. less MAbs, 2015 Feb 19; 7(3). PMID: 25692916 Free PMC article.
IL-15 temporally reorients IL-10 biased B-1a cells toward IL-12 expression. Amlan Kanti Ghosh, Debolina Sinha, +2 authors, Subhadeep Mukherjee, Ratna Biswas, Tapas Biswas. less Cell Mol Immunol, 2015 Mar 10; 13(2). PMID: 25748019 Free PMC article.
The Role of Anti-PD-1/PD-L1 Agents in Melanoma: Progress to Date. Katy K Tsai, Adil I Daud. Drugs, 2015 Mar 25; 75(6). PMID: 25802230 Review.
PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation. Li Liu, Qiangsun Zheng, +3 authors, Jun Lee, Zhiqiang Ma, Qiming Zhu, Zhiquan Wang. less J Cell Mol Med, 2015 Mar 27; 19(6). PMID: 25810125 Free PMC article.
NF-κB regulates PD-1 expression in macrophages. Alexander P R Bally, Peiyuan Lu, +4 authors, Jeremy M Boss. less J Immunol, 2015 Mar 27; 194(9). PMID: 25810391 Free PMC article.
Immune checkpoint blockade: a common denominator approach to cancer therapy. Suzanne L Topalian, Charles G Drake, Drew M Pardoll. Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804 Free PMC article. Highly Cited. Review.
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. Heinz Läubli, Cathrin Balmelli, +3 authors, Alfred Zippelius. less J Immunother Cancer, 2015 Apr 23; 3. PMID: 25901283 Free PMC article. Highly Cited.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. Jun Liu, Ying Yuan, +8 authors, Li Wang. less Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334 Free PMC article. Highly Cited.
Programmed death-1 controls T cell survival by regulating oxidative metabolism. Victor Tkachev, Stefanie Goodell, +5 authors, Craig A Byersdorfer. less J Immunol, 2015 May 15; 194(12). PMID: 25972478 Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Keishi Adachi, Koji Tamada. Cancer Sci, 2015 May 20; 106(8). PMID: 25981182 Free PMC article. Review.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia. Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo. Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611 Free PMC article. Review.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz. less N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255 Free PMC article. Highly Cited.
Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study. Hubert Kübler, Birgit Scheel, +17 authors, Arnulf Stenzl. less J Immunother Cancer, 2015 Jun 18; 3. PMID: 26082837 Free PMC article.
Inhibitory Receptors Beyond T Cell Exhaustion. Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser. Front Immunol, 2015 Jul 15; 6. PMID: 26167163 Free PMC article. Highly Cited. Review.
The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review. Si Chen, Yuan Li, +9 authors, Yongzhe Li. less Rheumatol Int, 2015 Aug 02; 36(1). PMID: 26232179 Review.
Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Francesca De Felice, Claudia Marchetti, +4 authors, Pierluigi Benedetti Panici. less J Immunol Res, 2015 Aug 04; 2015. PMID: 26236750 Free PMC article. Review.
Nivolumab in the treatment of malignant melanoma: review of the literature. Emi Mashima, Akiha Inoue, +10 authors, Motonobu Nakamura. less Onco Targets Ther, 2015 Aug 15; 8. PMID: 26273207 Free PMC article. Review.
Pembrolizumab. Leila Khoja, Marcus O Butler, +2 authors, S Peter Kang, Scot Ebbinghaus, Anthony M Joshua. less J Immunother Cancer, 2015 Aug 20; 3. PMID: 26288737 Free PMC article. Review.
Lung cancer: Biology and treatment options. Hassan Lemjabbar-Alaoui, Omer Ui Hassan, Yi-Wei Yang, Petra Buchanan. Biochim Biophys Acta, 2015 Aug 25; 1856(2). PMID: 26297204 Free PMC article. Highly Cited. Review.
The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients. Xinbing Sui, Junhong Ma, +5 authors, Li Zhang. less Oncotarget, 2015 Aug 26; 6(23). PMID: 26305724 Free PMC article. Review.
Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses. Karishma Rajani, Christopher Parrish, +10 authors, Richard Vile. less Mol Ther, 2015 Aug 28; 24(1). PMID: 26310630 Free PMC article. Highly Cited.
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. Lieping Chen, Xue Han. J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325035 Free PMC article. Highly Cited. Review.
The role of B-1 cells in inflammation. Monowar Aziz, Nichol E Holodick, Thomas L Rothstein, Ping Wang. Immunol Res, 2015 Oct 03; 63(1-3). PMID: 26427372 Free PMC article. Review.
Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies. Yi Xia, L Jeffrey Medeiros, Ken H Young. Biochim Biophys Acta, 2015 Oct 04; 1865(1). PMID: 26432723 Free PMC article. Review.
Human Cancer Immunotherapy with PD-1/PD-L1 Blockade. Peilin Zheng, Zhiguang Zhou. Biomark Cancer, 2015 Oct 09; 7(Suppl 2). PMID: 26448693 Free PMC article. Review.
Clinical significance of programmed death ligand-1 (PD-L1) in colorectal serrated adenocarcinoma. Hailong Zhu, Huali Qin, +6 authors, Xianghua Yi. less Int J Clin Exp Pathol, 2015 Oct 16; 8(8). PMID: 26464688 Free PMC article.
Immunotherapy and tumor microenvironment. Haidong Tang, Jian Qiao, Yang-Xin Fu. Cancer Lett, 2015 Oct 20; 370(1). PMID: 26477683 Free PMC article. Highly Cited. Review.
Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy. Mohamed L Salem, Ahmed El-Badawy. World J Hepatol, 2015 Oct 21; 7(23). PMID: 26483866 Free PMC article. Review.
Molecular profiling in the treatment of colorectal cancer: focus on regorafenib. Yiyi Yan, Axel Grothey. Onco Targets Ther, 2015 Oct 29; 8. PMID: 26508880 Free PMC article. Review.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy. Anna Śledzińska, Laurie Menger, +2 authors, Katharina Bergerhoff, Karl S Peggs, Sergio A Quezada. less Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451 Free PMC article. Review.
Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways. Cuiping Liu, Juean Jiang, +7 authors, Xueguang Zhang. less Arthritis Res Ther, 2015 Nov 27; 17. PMID: 26608464 Free PMC article.
Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery. Andrew M Bellinger, Carlos L Arteaga, +4 authors, Javid J Moslehi. less Circulation, 2015 Dec 09; 132(23). PMID: 26644247 Free PMC article. Review.
Synthetic RORγt Agonists Enhance Protective Immunity. Mi Ra Chang, Venkatasubramanian Dharmarajan, +5 authors, Patrick R Griffin. less ACS Chem Biol, 2016 Jan 20; 11(4). PMID: 26785144 Free PMC article.
An increased number of PD-1+ and Tim-3+ CD8+ T cells is involved in immune evasion in gastric cancer. Shuichi Takano, Hiroaki Saito, Masahide Ikeguchi. Surg Today, 2016 Jan 24; 46(11). PMID: 26801344
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes. Kerstin Sarter, Elisa Leimgruber, +16 authors, Walter Reith. less J Exp Med, 2016 Jan 27; 213(2). PMID: 26809444 Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella. Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028 Free PMC article. Review.
Basics of PD-1 in self-tolerance, infection, and cancer immunity. Shunsuke Chikuma. Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303 Review.
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Alison Taylor, James A Harker, +3 authors, Christopher E Rudd. less Immunity, 2016 Feb 18; 44(2). PMID: 26885856 Free PMC article.
PD-1 expression conditions T cell avidity within an antigen-specific repertoire. Sylvain Simon, Virginie Vignard, +4 authors, N Labarriere. less Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942093 Free PMC article.
Genetic and Epigenetic Regulation of PD-1 Expression. Alexander P R Bally, James W Austin, Jeremy M Boss. J Immunol, 2016 Mar 06; 196(6). PMID: 26945088 Free PMC article. Review.
Signaling in T cells - is anything the m(a)TOR with the picture(s)? Mark Boothby. F1000Res, 2016 Mar 08; 5. PMID: 26949528 Free PMC article. Review.
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection. Pushpa Jayaraman, Miye K Jacques, +6 authors, Samuel M Behar. less PLoS Pathog, 2016 Mar 12; 12(3). PMID: 26967901 Free PMC article. Highly Cited.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok. Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780 Free PMC article. Highly Cited. Review.
Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade. Haidong Tang, Yang Wang, +6 authors, Yang-Xin Fu. less Cancer Cell, 2016 Mar 16; 29(3). PMID: 26977880 Free PMC article. Highly Cited.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll. Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802 Free PMC article. Highly Cited. Review.
PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity. Tong Seng Lim, Valerie Chew, +4 authors, Paola Ricciardi-Castagnoli. less Oncoimmunology, 2016 May 04; 5(3). PMID: 27141339 Free PMC article.
A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage. Colette Dezutter-Dambuyant, Isabelle Durand, +10 authors, Christophe Caux. less Oncoimmunology, 2016 May 04; 5(3). PMID: 27141350 Free PMC article.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert. less Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885 Highly Cited. Review.
Enhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy. Jae Hun Shin, Hyung Bae Park, Kyungho Choi. Immune Netw, 2016 May 11; 16(2). PMID: 27162530 Free PMC article.
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. Jianxun Wang, Masayuki Mizui, +7 authors, Maria I Kontaridis. less J Clin Invest, 2016 May 18; 126(6). PMID: 27183387 Free PMC article.
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. Ana C Anderson, Nicole Joller, Vijay K Kuchroo. Immunity, 2016 May 19; 44(5). PMID: 27192565 Free PMC article. Highly Cited. Review.
Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria. Joshua M Horne-Debets, Deshapriya S Karunarathne, +3 authors, Michelle N Wykes. less Sci Rep, 2016 May 25; 6. PMID: 27217330 Free PMC article.
PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study. Hong-Tao Ren, Yi-Ming Li, +9 authors, Zhi-Jun Dai. less Medicine (Baltimore), 2016 May 27; 95(21). PMID: 27227944 Free PMC article.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy. Weijie Ma, Barbara M Gilligan, Jianda Yuan, Tianhong Li. J Hematol Oncol, 2016 May 29; 9(1). PMID: 27234522 Free PMC article. Highly Cited. Review.
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma. Naoka Murakami, Thiago J Borges, Michifumi Yamashita, Leonardo V Riella. Clin Kidney J, 2016 Jun 09; 9(3). PMID: 27274826 Free PMC article.
The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats. Mei Tian, Yonghong Zhang, +3 authors, Zhaozhao Liu, Guoqiang Sun, Gil Mor, Aihua Liao. less Sci Rep, 2016 Jun 10; 6. PMID: 27277012 Free PMC article.
FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. Ferenc Boldizsar, Oktavia Tarjanyi, +4 authors, Tibor A Rauch. less Cardiovasc Pathol, 2016 Jun 12; 25(5). PMID: 27288745 Free PMC article.
Metastatic melanoma and immunotherapy. Benjamin Herzberg, David E Fisher. Clin Immunol, 2016 Jul 20; 172. PMID: 27430520 Free PMC article. Review.
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. Robert Gibson, Jess Delaune, Anita Szady, Merry Markham. BMJ Case Rep, 2016 Jul 22; 2016. PMID: 27440853 Free PMC article.
Emerging treatments in management of prostate cancer: biomarker validation and endpoints for immunotherapy clinical trial design. Susan F Slovin. Immunotargets Ther, 2014 Jan 01; 3. PMID: 27471695 Free PMC article. Review.
Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy. Lucie Heinzerling, Patrick A Ott, +7 authors, Jason J Luke. less J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532025 Free PMC article. Highly Cited.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer. Benjamin Herzberg, Meghan J Campo, Justin F Gainor. Oncologist, 2016 Aug 19; 22(1). PMID: 27534574 Free PMC article. Review.
New targeted treatments for non-small-cell lung cancer - role of nivolumab. Giulia Zago, Mirte Muller, Michel van den Heuvel, Paul Baas. Biologics, 2016 Aug 19; 10. PMID: 27536062 Free PMC article. Review.
T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases. Eoin F McKinney, Kenneth Gc Smith. Immunol Cell Biol, 2016 Sep 01; 94(10). PMID: 27577866 Review.
Varicella-Zoster Virus Downregulates Programmed Death Ligand 1 and Major Histocompatibility Complex Class I in Human Brain Vascular Adventitial Fibroblasts, Perineurial Cells, and Lung Fibroblasts. Dallas Jones, Anna Blackmon, +4 authors, Maria A Nagel. less J Virol, 2016 Sep 16; 90(23). PMID: 27630241 Free PMC article.
Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report. Taofeek K Owonikoko, Mukesh Kumar, +10 authors, Suresh S Ramalingam. less Cancer Immunol Immunother, 2016 Oct 25; 66(1). PMID: 27771741 Free PMC article.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade. Douglas B Johnson, Justin M Balko, +29 authors, Javid J Moslehi. less N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806233 Free PMC article. Highly Cited.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. Vassiliki A Boussiotis. N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234 Free PMC article. Highly Cited. Review.
Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity. Tony T Jiang, Tijana Martinov, +4 authors, Sing Sing Way. less Cell Rep, 2016 Nov 10; 17(7). PMID: 27829150 Free PMC article.
Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy. Maarten Swart, Inge Verbrugge, Joost B Beltman. Front Oncol, 2016 Nov 17; 6. PMID: 27847783 Free PMC article. Highly Cited. Review.
Immunosuppression in liver tumors: opening the portal to effective immunotherapy. P Guha, J Reha, S C Katz. Cancer Gene Ther, 2016 Dec 03; 24(3). PMID: 27910858 Review.
Checkpoint inhibition in myeloma. Don M Benson. Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913525 Free PMC article. Review.
Immunoregulation in Fungal Diseases. Jonathan A Roussey, Michal A Olszewski, John J Osterholzer. Microorganisms, 2016 Dec 16; 4(4). PMID: 27973396 Free PMC article. Review.
PD-1 and its ligands are important immune checkpoints in cancer. Yinan Dong, Qian Sun, Xinwei Zhang. Oncotarget, 2016 Dec 16; 8(2). PMID: 27974689 Free PMC article. Highly Cited. Review.
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation. Kankana Bardhan, Theodora Anagnostou, Vassiliki A Boussiotis. Front Immunol, 2016 Dec 27; 7. PMID: 28018338 Free PMC article. Highly Cited. Review.
Genetically engineered mouse models in oncology research and cancer medicine. Kelly Kersten, Karin E de Visser, Martine H van Miltenburg, Jos Jonkers. EMBO Mol Med, 2016 Dec 29; 9(2). PMID: 28028012 Free PMC article. Highly Cited. Review.
A New VISTA on combination therapy for negative checkpoint regulator blockade. Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle. J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817 Free PMC article. Review.
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity. Kenji Chamoto, Partha S Chowdhury, +4 authors, Tasuku Honjo. less Proc Natl Acad Sci U S A, 2017 Jan 18; 114(5). PMID: 28096382 Free PMC article. Highly Cited.
Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Hui Zhang, Ryu Watanabe, +5 authors, Cornelia M Weyand. less Proc Natl Acad Sci U S A, 2017 Jan 25; 114(6). PMID: 28115719 Free PMC article. Highly Cited.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy. Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka. less Blood, 2017 Feb 06; 129(15). PMID: 28151427 Free PMC article. Highly Cited.
Renal complications of immune checkpoint blockade. Naoka Murakami, Shveta Motwani, Leonardo V Riella. Curr Probl Cancer, 2017 Feb 13; 41(2). PMID: 28189263 Free PMC article. Review.
CD103+ lung dendritic cells (LDCs) induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11bhi LDCs. Sudhanshu Shekhar, Ying Peng, Shuhe Wang, Xi Yang. Cell Mol Immunol, 2017 Feb 15; 15(4). PMID: 28194020 Free PMC article.
Cardiovascular Toxicities Associated with Cancer Immunotherapies. Daniel Y Wang, Gosife Donald Okoye, +2 authors, Thomas G Neilan, Douglas B Johnson, Javid J Moslehi. less Curr Cardiol Rep, 2017 Feb 22; 19(3). PMID: 28220466 Highly Cited. Review.
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer. Andreas D Hartkopf, Florin-Andrei Taran, +4 authors, Sara Y Brucker. less Breast Care (Basel), 2017 Feb 24; 11(6). PMID: 28228704 Free PMC article. Review.
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy. Eszter Lázár-Molnár, Lisa Scandiuzzi, +7 authors, Steven C Almo. less EBioMedicine, 2017 Feb 25; 17. PMID: 28233730 Free PMC article.
Inflammatory cytokines compromise programmed cell death-1 (PD-1)-mediated T cell suppression in inflammatory arthritis through up-regulation of soluble PD-1. D Bommarito, C Hall, L S Taams, V M Corrigall. Clin Exp Immunol, 2017 Mar 01; 188(3). PMID: 28245522 Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors. Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim. Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545 Free PMC article. Review.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma. Liliana E Lucca, David A Hafler. Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696 Free PMC article. Review.
Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Leslie S Kean, Laurence A Turka, Bruce R Blazar. Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258702 Free PMC article. Review.
In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network. Kaitao Li, Xiaoxiao Cheng, +2 authors, Andreas Tilevik, Simon J Davis, Cheng Zhu. less J Biol Chem, 2017 Mar 09; 292(16). PMID: 28270509 Free PMC article.
Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients. Hui Shi, Junna Ye, +13 authors, Chengde Yang. less Arthritis Res Ther, 2017 Mar 10; 19(1). PMID: 28274252 Free PMC article.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma. Manohan Sinnadurai, Kerrie L McDonald. J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764 Review.
Imaging and clinicopathological features of nivolumab-related cholangitis in patients with non-small cell lung cancer. Hisato Kawakami, Junko Tanizaki, +11 authors, Kazuhiko Nakagawa. less Invest New Drugs, 2017 Mar 21; 35(4). PMID: 28317087
Clinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients. Takashi Nomizo, Hiroaki Ozasa, +8 authors, Young Hak Kim. less Sci Rep, 2017 Mar 24; 7. PMID: 28332580 Free PMC article.
Cancer immunotherapies targeting the PD-1 signaling pathway. Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo. J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884 Free PMC article. Highly Cited. Review.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors. Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri. less Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974 Free PMC article. Review.
The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent. Claire Briet, Gwladys Bourdenet, +9 authors, Christian Boitard. less Front Immunol, 2017 Apr 21; 8. PMID: 28424681 Free PMC article.
Checkpoint inhibitors in hematological malignancies. Chi Young Ok, Ken H Young. J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851 Free PMC article. Highly Cited. Review.
Targeting the programmed cell death-1 pathway in rheumatoid arthritis. Sabina Sandigursky, Gregg J Silverman, Adam Mor. Autoimmun Rev, 2017 Jun 03; 16(8). PMID: 28572054 Free PMC article. Review.
Autoimmune Diabetes and Thyroiditis Complicating Treatment with Nivolumab. Li Li, Awais Masood, +2 authors, Shahla Bari, Sahzene Yavuz, Alan B Grosbach. less Case Rep Oncol, 2017 Jun 15; 10(1). PMID: 28611636 Free PMC article.
The emerging role of immune checkpoint based approaches in AML and MDS. Prajwal Boddu, Hagop Kantarjian, +3 authors, Naval Daver. less Leuk Lymphoma, 2017 Jul 07; 59(4). PMID: 28679300 Free PMC article. Review.
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors. Andrew Gibson, Lee Faulkner, +8 authors, Dean J Naisbitt. less J Immunol, 2017 Jul 09; 199(4). PMID: 28687658 Free PMC article.
Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis. Hyosun Cho, Hyojeung Kang, Hwan Hee Lee, Chang Wook Kim. Int J Mol Sci, 2017 Jul 14; 18(7). PMID: 28703774 Free PMC article. Review.
Developing Cures: Targeting Ontogenesis in Cancer. Victor T G Lin, Hawley C Pruitt, Rajeev S Samant, Lalita A Shevde. Trends Cancer, 2017 Jul 19; 3(2). PMID: 28718443 Free PMC article. Review.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour. less ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757 Free PMC article. Highly Cited. Review.
Lung cancer as a cardiotoxic state: a review. David Pérez-Callejo, María Torrente, +2 authors, Mariano Provencio. less Med Oncol, 2017 Aug 11; 34(9). PMID: 28795306 Review.
A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma. Naoya Maekawa, Satoru Konnai, +13 authors, Kazuhiko Ohashi. less Sci Rep, 2017 Aug 23; 7(1). PMID: 28827658 Free PMC article.
The promise of immunotherapy in head and neck squamous cell carcinoma: combinatorial immunotherapy approaches. Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri. ESMO Open, 2017 Aug 30; 1(6). PMID: 28848660 Free PMC article. Review.
Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40. David J Messenheimer, Shawn M Jensen, +6 authors, Bernard A Fox. less Clin Cancer Res, 2017 Sep 01; 23(20). PMID: 28855348 Free PMC article. Highly Cited.
Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights. Ping-Pin Zheng, Jin Li, Johan M Kros. Med Res Rev, 2017 Sep 02; 38(1). PMID: 28862319 Free PMC article. Review.
Immune checkpoint inhibitors in cancer therapy. Eika S Webb, Peng Liu, +3 authors, Yao-He Wang. less J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656 Free PMC article.
Tim-3, Lag-3, and TIGIT. Nicole Joller, Vijay K Kuchroo. Curr Top Microbiol Immunol, 2017 Sep 14; 410. PMID: 28900677 Free PMC article. Review.
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis. Romualdo Barroso-Sousa, William T Barry, +4 authors, Sara M Tolaney. less JAMA Oncol, 2017 Oct 04; 4(2). PMID: 28973656 Free PMC article. Highly Cited. Systematic Review.
The diverse functions of the PD1 inhibitory pathway. Arlene H Sharpe, Kristen E Pauken. Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585 Highly Cited. Review.
Control of NK Cell Activation by Immune Checkpoint Molecules. Asma Beldi-Ferchiou, Sophie Caillat-Zucman. Int J Mol Sci, 2017 Oct 13; 18(10). PMID: 29023417 Free PMC article. Review.
MAGT1-mediated disturbance of Mg2+ homeostasis lead to exhausted of HBV-infected NK and CD8+ T cells. Bo Diao, Xiaoyong Huang, +4 authors, Yuzhang Wu. less Sci Rep, 2017 Oct 21; 7(1). PMID: 29051561 Free PMC article.
Checkpoint inhibitor-induced uveitis: a case series. Christopher D Conrady, Marissa Larochelle, +3 authors, Ajay Singh. less Graefes Arch Clin Exp Ophthalmol, 2017 Oct 29; 256(1). PMID: 29080102
HLA-mediated tumor escape mechanisms that may impair immunotherapy clinical outcomes via T-cell activation. Josefa A Rodríguez. Oncol Lett, 2017 Nov 01; 14(4). PMID: 29085437 Free PMC article.
Cardiotoxicity of immune checkpoint inhibitors. Gilda Varricchi, Maria Rosaria Galdiero, +5 authors, Carlo Gabriele Tocchetti. less ESMO Open, 2017 Nov 07; 2(4). PMID: 29104763 Free PMC article. Highly Cited. Review.
Live Cell Labeling with Terpyridine Derivative Proligands to Measure Cytotoxicity Mediated by Immune Cells. Yuki Sakai, Satoshi Mizuta, +5 authors, Yoshimasa Tanaka. less ChemMedChem, 2017 Nov 08; 12(23). PMID: 29110403 Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer. R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs. Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554 Free PMC article. Review.
PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective. Palanisamy Nallasamy, Srinivas Chava, +7 authors, Kishore B Challagundla. less Semin Cancer Biol, 2017 Dec 03; 52(Pt 2). PMID: 29196189 Free PMC article. Review.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy. Robert J Torphy, Richard D Schulick, Yuwen Zhu. Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042 Free PMC article. Review.
PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease. Kathryn W Juchem, Faruk Sacirbegovic, +6 authors, Warren D Shlomchik. less J Immunol, 2017 Dec 08; 200(2). PMID: 29212909 Free PMC article.
Investigational PD-1 inhibitors in HL and NHL and biomarkers for predictors of response and outcome. Andres Chang, Danielle Schlafer, Christopher R Flowers, Pamela B Allen. Expert Opin Investig Drugs, 2017 Dec 13; 27(1). PMID: 29228840 Free PMC article. Review.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response? Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young. Front Immunol, 2017 Dec 20; 8. PMID: 29255458 Free PMC article. Highly Cited. Review.
Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma. Hassan Sadozai, Thomas Gruber, Robert Emil Hunger, Mirjam Schenk. Front Immunol, 2017 Dec 26; 8. PMID: 29276510 Free PMC article. Review.
Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor. Michael Peled, Anna S Tocheva, +10 authors, Adam Mor. less Proc Natl Acad Sci U S A, 2017 Dec 29; 115(3). PMID: 29282323 Free PMC article.
Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade. Jie Bai, Zhitao Gao, +3 authors, Xiang Li, Liang Dong, Weidong Han, Jing Nie. less Oncotarget, 2018 Jan 05; 8(66). PMID: 29299180 Free PMC article. Review.
The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. Stefan Frantz, Ines Falcao-Pires, +16 authors, Stephane Heymans. less Eur J Heart Fail, 2018 Jan 16; 20(3). PMID: 29333691 Free PMC article. Highly Cited. Review.
Clinical Development of PD-1 in Advanced Melanoma. Rodrigo Ramella Munhoz, Michael Andrew Postow. Cancer J, 2018 Jan 24; 24(1). PMID: 29360722 Free PMC article. Review.
Inhibition of the checkpoint protein PD-1 by the therapeutic antibody pembrolizumab outlined by quantum chemistry. Ana Beatriz M L A Tavares, José X Lima Neto, Umberto L Fulco, Eudenilson L Albuquerque. Sci Rep, 2018 Feb 01; 8(1). PMID: 29382901 Free PMC article.
Multifunctional nanoparticles for cancer immunotherapy: A groundbreaking approach for reprogramming malfunctioned tumor environment. Samaresh Sau, Hashem O Alsaab, +3 authors, Arun K Iyer. less J Control Release, 2018 Feb 03; 274. PMID: 29391232 Free PMC article. Highly Cited. Review.
Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies. Danuta J Herzyk, Helen G Haggerty. AAPS J, 2018 Feb 09; 20(2). PMID: 29417397 Review.
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice. Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng. less Cell Res, 2018 Feb 22; 28(4). PMID: 29463898 Free PMC article. Highly Cited.
PD-1 is required to maintain stem cell properties in human dental pulp stem cells. Yao Liu, Huan Jing, +5 authors, Songtao Shi. less Cell Death Differ, 2018 Feb 24; 25(7). PMID: 29472716 Free PMC article.
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression. Yanxia Guo, Alice M Walsh, +18 authors, Sunil Nagpal. less PLoS One, 2018 Mar 01; 13(2). PMID: 29489833 Free PMC article. Highly Cited.
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells. Thomas Menter, Alexandar Tzankov. Front Oncol, 2018 Mar 23; 8. PMID: 29564225 Free PMC article. Review.
Serial Troponin for Early Detection of Nivolumab Cardiotoxicity in Advanced Non-Small Cell Lung Cancer Patients. Matteo Sarocchi, Francesco Grossi, +12 authors, Paolo Spallarossa. less Oncologist, 2018 Mar 24; 23(8). PMID: 29567824 Free PMC article.
Evaluation of programmed cell death protein 1 (PD-1) expression as a prognostic biomarker in patients with clear cell renal cell carcinoma. Kyu Seo Kim, Rishi R Sekar, +5 authors, Viraj A Master. less Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632730 Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies. Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok. Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946 Free PMC article. Highly Cited. Review.
Electrophysiologic Toxicity of Chemoradiation. Merna A Armanious, Shreya Mishra, Michael G Fradley. Curr Oncol Rep, 2018 Apr 13; 20(6). PMID: 29644475 Review.
Cardiotoxicity of Immunotherapy: Incidence, Diagnosis, and Management. Aarti Asnani. Curr Oncol Rep, 2018 Apr 13; 20(6). PMID: 29644505 Review.
The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response? Laura de Ramon, Jordi Guiteras, +3 authors, Juan Torras. less Int J Mol Sci, 2018 Apr 26; 19(5). PMID: 29693595 Free PMC article. Review.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5. Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber. Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673 Free PMC article. Review.
Immune checkpoint receptors: homeostatic regulators of immunity. Antonio Riva, Shilpa Chokshi. Hepatol Int, 2018 May 10; 12(3). PMID: 29740793 Free PMC article. Review.
T Follicular Regulatory Cells and Antibody Responses in Transplantation. Elizabeth F Wallin. Transplantation, 2018 May 15; 102(10). PMID: 29757907 Free PMC article. Review.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer. Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang. less J Mol Biol, 2018 May 26; 430(14). PMID: 29800567 Free PMC article. Review.
Immune Checkpoint Inhibitor-Associated Myocarditis. Sarju Ganatra, Tomas G Neilan. Oncologist, 2018 May 29; 23(8). PMID: 29802219 Free PMC article. Highly Cited.
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes. Kevin C Osum, Adam L Burrack, +8 authors, Brian T Fife. less Sci Rep, 2018 May 31; 8(1). PMID: 29844327 Free PMC article.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses. Teresa Nguyen, Naze G Avci, +2 authors, Dong Ho Shin, Naiara Martinez-Velez, Hong Jiang. less Cancers (Basel), 2018 Jun 03; 10(6). PMID: 29857493 Free PMC article. Review.
Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens. Mengjia Song, Xinfeng Chen, Liping Wang, Yi Zhang. Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861603 Free PMC article.
Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis. Heidi Harjunpää, Stephen J Blake, +12 authors, Michele W L Teng. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900061 Free PMC article.
Proliferative CD8(+) PD-1(+) T-cell infiltration in a pembrolizumab-induced cutaneous adverse reaction. Kei Kunimasa, Taiki Isei, +9 authors, Fumio Imamura. less Invest New Drugs, 2018 Jun 28; 36(6). PMID: 29947012
Clinicopathological value of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) expression in synovium of patients with rheumatoid arthritis. Kotaro Matsuda, Hiroaki Miyoshi, +6 authors, Koichi Ohshima. less Clin Exp Med, 2018 Jul 02; 18(4). PMID: 29961175
Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity. Jiu-Cheng Zhang, Wei-Dong Chen, +6 authors, Hua Zhu. less Acta Pharmacol Sin, 2018 Jul 12; 39(11). PMID: 29991709 Free PMC article. Review.
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Coronary Toxicities of Anti-PD-1 and Anti-PD-L1 Immunotherapies: a Case Report and Review of the Literature and International Registries. Marion Ferreira, Eric Pichon, +6 authors, Sylvain Marchand-Adam. less Target Oncol, 2018 Jul 15; 13(4). PMID: 30006825 Review.
Regulatory Role of CD4+ T Cells in Myocarditis. Daria Vdovenko, Urs Eriksson. J Immunol Res, 2018 Jul 24; 2018. PMID: 30035131 Free PMC article. Review.
Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Yuli Cheng, Xing Zhu, +6 authors, Xinping Zhu. less Front Immunol, 2018 Aug 11; 9. PMID: 30093899 Free PMC article.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options. Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül. Front Immunol, 2018 Aug 31; 9. PMID: 30158932 Free PMC article. Review.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints. Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min. less Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160 Free PMC article. Review.
Combining immunotherapy with radiation therapy in thoracic oncology. Shahed N Badiyan, Michael C Roach, +7 authors, Charles B Simone. less J Thorac Dis, 2018 Sep 13; 10(Suppl 21). PMID: 30206494 Free PMC article. Review.
Mechanism and Management of Cancer Chemotherapy-Induced Atherosclerosis. Mikio Mukai, Keiko Komori, Toru Oka. J Atheroscler Thromb, 2018 Sep 19; 25(10). PMID: 30224607 Free PMC article. Review.
Not All Immune Checkpoints Are Created Equal. Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger. Front Immunol, 2018 Sep 21; 9. PMID: 30233564 Free PMC article. Highly Cited. Review.
EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity. Michael Peled, Matthew A Dragovich, +4 authors, Adam Mor. less J Immunol, 2018 Oct 03; 201(9). PMID: 30275048 Free PMC article.
Immune Checkpoints as Therapeutic Targets in Autoimmunity. Christopher Paluch, Ana Mafalda Santos, +2 authors, Simon J Davis. less Front Immunol, 2018 Oct 24; 9. PMID: 30349540 Free PMC article. Review.
Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again. Samantha L Bucktrout, Jeffrey A Bluestone, Fred Ramsdell. Genome Med, 2018 Nov 01; 10(1). PMID: 30376867 Free PMC article. Review.
Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells. Suresh Pallikkuth, Rajendra Pahwa, +9 authors, Savita Pahwa. less PLoS One, 2018 Nov 01; 13(10). PMID: 30379878 Free PMC article.
Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression. Elena Gianchecchi, Alessandra Fierabracci. Front Immunol, 2018 Nov 06; 9. PMID: 30386337 Free PMC article. Highly Cited. Review.
Immune Checkpoint Inhibitor-Related Cardiotoxicity. Barry Trachtenberg, Fahd Hussain, +2 authors, Sai Ravi Kiran Pingali. less Methodist Debakey Cardiovasc J, 2018 Nov 10; 14(3). PMID: 30410661 Free PMC article.
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Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study. Joe-Elie Salem, Ali Manouchehri, +10 authors, Javid J Moslehi. less Lancet Oncol, 2018 Nov 18; 19(12). PMID: 30442497 Free PMC article. Highly Cited.
The Role of Leukocytes in Diabetic Cardiomyopathy. Anamika Bajpai, Douglas G Tilley. Front Physiol, 2018 Nov 18; 9. PMID: 30443223 Free PMC article. Review.
Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia. Koutaro Takamatsu, Shunya Nakane, +11 authors, Yukio Ando. less Ann Clin Transl Neurol, 2018 Nov 28; 5(11). PMID: 30480036 Free PMC article.
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway. Jianqin Lu, Xiangsheng Liu, +6 authors, Andre E Nel. less ACS Nano, 2018 Nov 30; 12(11). PMID: 30481959 Free PMC article.
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Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance. Georgia Fousteri, Amy Dave Jhatakia. Viruses, 2019 Sep 25; 11(10). PMID: 31546586 Free PMC article. Review.
Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure. Patricia van den Hoogen, Saskia C A de Jager, +10 authors, Joost P G Sluijter. less J Cell Mol Med, 2019 Sep 27; 23(11). PMID: 31557411 Free PMC article.
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A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer. Xi Li, Rouzheng Wang, +25 authors, Tao Dong. less Front Oncol, 2019 Nov 12; 9. PMID: 31709176 Free PMC article.
Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells. Kankana Bardhan, Halil-Ibrahim Aksoylar, +6 authors, Vassiliki A Boussiotis. less Sci Rep, 2019 Nov 23; 9(1). PMID: 31754127 Free PMC article.
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Immune Checkpoint Inhibitor-Associated Cardiotoxicity: Current Understanding on Its Mechanism, Diagnosis and Management. Yu-Wen Zhou, Ya-Juan Zhu, +6 authors, Ji-Yan Liu. less Front Pharmacol, 2019 Dec 19; 10. PMID: 31849640 Free PMC article. Review.
Combined induction with anti-PD-1 and anti-CTLA-4 antibodies provides synergistic antitumor effects in DC-CIK cells in renal carcinoma cell lines. Zhaohu Yuan, Huikuan Yang, Yaming Wei. Int J Clin Exp Pathol, 2020 Jan 15; 12(1). PMID: 31933726 Free PMC article.
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Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block. Alisha Khan, Sana Riaz, Robert Carhart. Case Rep Cardiol, 2020 Feb 13; 2020. PMID: 32047674 Free PMC article.
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment. Nicolas Palaskas, Juan Lopez-Mattei, +2 authors, Jean Bernard Durand, Cezar Iliescu, Anita Deswal. less J Am Heart Assoc, 2020 Jan 22; 9(2). PMID: 31960755 Free PMC article. Review.
T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy. Pamela D Winterberg, Jennifer M Robertson, +2 authors, Michael S Kelleman, Roshan P George, Mandy L Ford. less J Am Soc Nephrol, 2019 Feb 08;. PMID: 30728178 Free PMC article.
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Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity. Yu Fujita, Roberto Tinoco, +2 authors, Yan Li, Daniela Senft, Ze'ev A Ronai. less Trends Mol Med, 2019 Mar 23; 25(5). PMID: 30898473 Free PMC article. Review.
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States. Spencer C Wei, Roshan Sharma, +8 authors, James P Allison. less Immunity, 2019 Mar 31; 50(4). PMID: 30926234 Free PMC article.
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance. Günther Schönrich, Martin J Raftery. Front Cell Infect Microbiol, 2019 Jul 03; 9. PMID: 31263684 Free PMC article. Highly Cited. Review.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges. Kei Kunimasa, Taichiro Goto. Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413 Free PMC article. Review.
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Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review. Shujing Liang, Jingxian Yang, +4 authors, Chunyan Dong. less Front Immunol, 2021 Jul 27; 12. PMID: 34305915 Free PMC article. Review.
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Immunotherapy-Related Cystitis: Case Report and Review of the Literature. Liping Zhu, Zhiqiang Wang, +2 authors, Justin Stebbing, Zibing Wang, Ling Peng. less Onco Targets Ther, 2021 Aug 10; 14. PMID: 34366676 Free PMC article.
Immune Checkpoint Inhibitors and Cardiotoxicity: An Analysis of Spontaneous Reports in Eudravigilance. Annamaria Mascolo, Cristina Scavone, +8 authors, Annalisa Capuano. less Drug Saf, 2021 Jun 20; 44(9). PMID: 34145536 Free PMC article.
Immune Checkpoint Inhibitors in Special Populations. Qianyun Shan, Hongyang Lu. Technol Cancer Res Treat, 2021 Aug 14; 20. PMID: 34384286 Free PMC article. Review.
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The Role of Oncogenes and Redox Signaling in the Regulation of PD-L1 in Cancer. Christophe Glorieux, Xiaojun Xia, Peng Huang. Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503236 Free PMC article. Review.
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Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH. Sunil Kumar, Parth Sarthi, +4 authors, Yong-Soo Bae. less Cells, 2021 Sep 29; 10(9). PMID: 34571899 Free PMC article. Review.
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The Upregulation of Molecules Related to Tumor Immune Escape in Human Pituitary Adenomas. Zhiyu Xi, Pamela S Jones, +8 authors, Xun Zhang. less Front Endocrinol (Lausanne), 2021 Nov 09; 12. PMID: 34745002 Free PMC article.
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Biological Bases of Immune-Related Adverse Events and Potential Crosslinks With Immunogenic Effects of Radiation. Lilia Bardoscia, Nadia Pasinetti, +2 authors, Luca Triggiani, Salvatore Cozzi, Angela Sardaro. less Front Pharmacol, 2021 Nov 19; 12. PMID: 34790123 Free PMC article. Review.
Unravelling Checkpoint Inhibitor Associated Autoimmune Diabetes: From Bench to Bedside. Linda Wu, Venessa H M Tsang, +5 authors, Jenny E Gunton. less Front Endocrinol (Lausanne), 2021 Nov 23; 12. PMID: 34803927 Free PMC article. Review.
Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Clemens Hinterleitner, Jasmin Strähle, +20 authors, Lars Zender. less Nat Commun, 2021 Dec 03; 12(1). PMID: 34853305 Free PMC article.
Role of the PD-1/PD-L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions. Yan Mi, Jinming Han, Jie Zhu, Tao Jin. Mol Neurobiol, 2021 Sep 05; 58(12). PMID: 34480337 Free PMC article. Review.
Role of PD-L1 in licensing immunoregulatory function of dental pulp mesenchymal stem cells. Rosanna Di Tinco, Giulia Bertani, +11 authors, Gianluca Carnevale. less Stem Cell Res Ther, 2021 Dec 06; 12(1). PMID: 34863286 Free PMC article.
Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy. Nicolas Jacquelot, Maryam Ghaedi, +3 authors, Pamela S Ohashi. less Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885076 Free PMC article. Review.
Immunotherapy of Ovarian Cancer with Particular Emphasis on the PD-1/PDL-1 as Target Points. Janina Świderska, Mateusz Kozłowski, Sebastian Kwiatkowski, Aneta Cymbaluk-Płoska. Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885169 Free PMC article. Review.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial. Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg. Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915 Review.
Case Report: Cardiac Toxicity Associated With Immune Checkpoint Inhibitors. Ru Chen, Ling Peng, +4 authors, Feng Zhu. less Front Cardiovasc Med, 2021 Dec 24; 8. PMID: 34938778 Free PMC article.
Cardiotoxicity and Chemotherapy-The Role of Precision Medicine. Thyla Viswanathan, Chim C Lang, Russell D Petty, Mark A Baxter. Diseases, 2021 Dec 24; 9(4). PMID: 34940028 Free PMC article. Review.
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy. Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern. less Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146 Free PMC article. Review.
Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. Markus P Kummer, Christina Ising, +11 authors, Michael T Heneka. less EMBO J, 2021 Nov 27; 40(24). PMID: 34825707 Free PMC article.
Bradyarrhythmias in Cardio-Oncology. Marta Fonseca, Evaline Cheng, +5 authors, Avirup Guha. less South Asian J Cancer, 2021 Dec 31; 10(3). PMID: 34966697 Free PMC article.
pH Low Insertion Peptide-Modified Programmed Cell Death-Ligand 1 Potently Suppresses T-Cell Activation Under Acidic Condition. Ying Sun, Linhan Hu, +11 authors, Guojiang Chen. less Front Immunol, 2022 Jan 11; 12. PMID: 35003115 Free PMC article.
Metabolic Implications of Immune Checkpoint Proteins in Cancer. Elizabeth R Stirling, Steven M Bronson, +3 authors, David R Soto-Pantoja. less Cells, 2022 Jan 12; 11(1). PMID: 35011741 Free PMC article. Review.
Strategies to overcome drug resistance using SHP2 inhibitors. Meng Liu, Shan Gao, +2 authors, Reham M Elhassan, Xuben Hou, Hao Fang. less Acta Pharm Sin B, 2022 Jan 14; 11(12). PMID: 35024315 Free PMC article. Review.
Immune-checkpoint inhibitors: long-term implications of toxicity. Douglas B Johnson, Caroline A Nebhan, Javid J Moslehi, Justin M Balko. Nat Rev Clin Oncol, 2022 Jan 28; 19(4). PMID: 35082367 Free PMC article. Review.
Vitamin D can reduce severity in COVID-19 through regulation of PD-L1. Hatice Aygun. Naunyn Schmiedebergs Arch Pharmacol, 2022 Feb 01; 395(4). PMID: 35099571 Free PMC article. Review.
A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy. Jin Bian, Yan Niu, +2 authors, Yanli Ma, Fuhua Chen, Ning Ma. less Appl Bionics Biomech, 2022 Feb 08; 2022. PMID: 35126664 Free PMC article.
Sudden and severe cardiotoxicity induced with pembrolizumab, its clinical course, therapeutic intervention, and outcome. Tomohiro Matsumoto, Koji Fukuda, +9 authors, Hiroyuki Shibata. less Int Cancer Conf J, 2022 Feb 08; 11(1). PMID: 35127324 Free PMC article.
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Daisuke Sugiura, Il-Mi Okazaki, +6 authors, Taku Okazaki. less Nat Immunol, 2022 Feb 12; 23(3). PMID: 35145298
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1. Yuwei Hao, Matthew C Cook. Front Immunol, 2022 Feb 15; 12. PMID: 35154081 Free PMC article. Review.
Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors. Sherry-Ann Brown, Jordan C Ray, Joerg Herrmann. J Cardiovasc Transl Res, 2020 Apr 08; 13(3). PMID: 32253744 Free PMC article. Review.
The Potential Cardiotoxicity of Immune Checkpoint Inhibitors. Inbar Nardi Agmon, Osnat Itzhaki Ben Zadok, Ran Kornowski. J Clin Med, 2022 Feb 16; 11(3). PMID: 35160316 Free PMC article. Review.
Overexpression of Programmed Cell Death 1 Prevents Doxorubicin-Induced Apoptosis Through Autophagy Induction in H9c2 Cardiomyocytes. Syu-Ichi Kanno, Akiyoshi Hara. Cardiovasc Toxicol, 2022 Feb 23; 22(5). PMID: 35190965 Free PMC article.
The Diagnosis and Management of Immune Checkpoint Inhibitor Cardiovascular Toxicity: Myocarditis and Beyond. Dan Gilon, Zaza Iakobishvili, David Leibowitz. Vaccines (Basel), 2022 Feb 27; 10(2). PMID: 35214762 Free PMC article. Review.
Cardiotoxicity risk factors with immune checkpoint inhibitors. Zachary L Brumberger, Mary E Branch, +3 authors, Sujethra Vasu. less Cardiooncology, 2022 Mar 13; 8(1). PMID: 35277208 Free PMC article.
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors. Alan H Baik, Katy K Tsai, David Y Oh, Mandar A Aras. Clin Sci (Lond), 2021 Mar 10; 135(5). PMID: 33686402 Free PMC article. Review.
CMTM6 as a master regulator of PD-L1. Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani. Cancer Immunol Immunother, 2022 Mar 17;. PMID: 35294592 Review.
Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors. Xin Du, Phillip K Darcy, Florian Wiede, Tony Tiganis. Mol Cell Biol, 2022 Jan 19; 42(3). PMID: 35041491 Free PMC article.
Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy. Jii Bum Lee, Hye Ryun Kim, Sang-Jun Ha. Immune Netw, 2022 Mar 17; 22(1). PMID: 35291660 Free PMC article. Review.
Checkpoint Inhibitors and Induction of Celiac Disease-like Condition. Aaron Lerner, Carina Benzvi. Biomedicines, 2022 Mar 26; 10(3). PMID: 35327411 Free PMC article. Review.
Effects of PD-1 Signaling on Immunometabolic Reprogramming. Vassiliki A Boussiotis, Nikolaos Patsoukis. Immunometabolism, 2022 Apr 05; 4(2). PMID: 35371563 Free PMC article.
Immune Checkpoint Therapies and Atherosclerosis: Mechanisms and Clinical Implications: JACC State-of-the-Art Review. Jacqueline T Vuong, Ashley F Stein-Merlob, +3 authors, Eric H Yang. less J Am Coll Cardiol, 2022 Feb 12; 79(6). PMID: 35144750 Free PMC article. Review.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis. Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom. Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201 Review.
A Systematic Review of the Mechanisms Involved in Immune Checkpoint Inhibitors Cardiotoxicity and Challenges to Improve Clinical Safety. Nestor Rubio-Infante, Yoel Adbel Ramírez-Flores, +3 authors, Guillermo Torre-Amione. less Front Cell Dev Biol, 2022 Apr 19; 10. PMID: 35433707 Free PMC article.
Combining Radiotherapy and Immunotherapy in Metastatic Breast Cancer: Current Status and Future Directions. Steven David, Jennifer Tan, +3 authors, Sherene Loi. less Biomedicines, 2022 Apr 24; 10(4). PMID: 35453571 Free PMC article. Review.
Exploring the Mechanisms Underlying the Cardiotoxic Effects of Immune Checkpoint Inhibitor Therapies. Daniel Ronen, Aseel Bsoul, +4 authors, Rabea Asleh. less Vaccines (Basel), 2022 Apr 24; 10(4). PMID: 35455289 Free PMC article. Review.
Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events. Remo Poto, Teresa Troiani, +4 authors, Gilda Varricchi. less Front Immunol, 2022 Apr 19; 13. PMID: 35432346 Free PMC article. Review.
Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues. Christopher M Bailey, Yan Liu, +5 authors, Yin Wang. less J Clin Invest, 2022 Mar 04; 132(9). PMID: 35239514 Free PMC article.
Melanoma: An immunotherapy journey from bench to bedside. Vishal Navani, Moira C Graves, +4 authors, Nikola A Bowden. less Cancer Treat Res, 2022 May 14; 183. PMID: 35551656
Genetics of cancer therapy-associated cardiotoxicity. Yuri Kim, Jonathan G Seidman, Christine E Seidman. J Mol Cell Cardiol, 2022 Apr 01; 167. PMID: 35358500 Free PMC article. Review.

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