Journal Article
. 2001 Feb; 291(5502):319-22.
doi: 10.1126/science.291.5502.319.

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

H Nishimura 1 T Okazaki  Y Tanaka  K Nakatani  M Hara  A Matsumori  S Sasayama  A Mizoguchi  H Hiai  N Minato  T Honjo  
Affiliations
  • PMID: 11209085
  •     629 citations

Abstract

Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mice, but not in BALB/c RAG-2-/- mice, caused dilated cardiomyopathy with severely impaired contraction and sudden death by congestive heart failure. Affected hearts showed diffuse deposition of immunoglobulin G (IgG) on the surface of cardiomyocytes. All of the affected PD-1-/- mice exhibited high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes. These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.

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Prakash Manikwar, Paul Kiptoo, +2 authors, Teruna J Siahaan.
Med Res Rev, 2011 Mar 25; 32(4). PMID: 21433035    Free PMC article.
Review.
Co-inhibitory molecules: Controlling the effectors or controlling the controllers?
Govindarajan Thangavelu, Christa Smolarchuk, Colin C Anderson.
Self Nonself, 2011 Apr 14; 1(2). PMID: 21487510    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Jeffrey A Bluestone.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898    Free PMC article.
Highly Cited. Review.
Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation.
Shinya Ueki, Antonino Castellaneta, +11 authors, Noriko Murase.
Hepatology, 2011 Apr 20; 54(1). PMID: 21503939    Free PMC article.
Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection.
S Rameeza Allie, Weijun Zhang, Shinchiro Fuse, Edward J Usherwood.
J Immunol, 2011 Apr 29; 186(11). PMID: 21525385    Free PMC article.
Searching for "signal 2": costimulation requirements of γδ T cells.
Julie C Ribot, Ana debarros, Bruno Silva-Santos.
Cell Mol Life Sci, 2011 May 05; 68(14). PMID: 21541698
Review.
Divide and conquer: Blocking graft versus host but not graft versus leukemia T cells with agonist BTLA co-inhibitory signals.
Govindarajan Thangavelu, Colin C Anderson.
Chimerism, 2011 May 07; 2(1). PMID: 21547036    Free PMC article.
PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine.
Jacalyn Rosenblatt, Brett Glotzbecker, +10 authors, David Avigan.
J Immunother, 2011 May 18; 34(5). PMID: 21577144    Free PMC article.
Highly Cited.
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice.
Hongmei Peng, Xiao-Ping Yang, +8 authors, Nour-Eddine Rhaleb.
Exp Physiol, 2011 May 24; 96(8). PMID: 21602297    Free PMC article.
Costimulatory pathways in transplantation.
Nina Pilat, Mohamed H Sayegh, Thomas Wekerle.
Semin Immunol, 2011 May 28; 23(4). PMID: 21616680    Free PMC article.
cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells.
Petra Verdino, Deborah A Witherden, +3 authors, Ian A Wilson.
PLoS One, 2011 Jun 02; 6(5). PMID: 21629689    Free PMC article.
Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.
Tao Shen, Jiajia Zheng, +5 authors, Fengmin Lu.
Virol J, 2011 Jun 08; 8. PMID: 21645420    Free PMC article.
Prostate cancer immunotherapy.
Kenneth F May, James L Gulley, +2 authors, Philip W Kantoff.
Clin Cancer Res, 2011 Jun 28; 17(16). PMID: 21700764    Free PMC article.
Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets.
Chuanwu Wang, Peter Hillsamer, Chang H Kim.
BMC Immunol, 2011 Sep 15; 12. PMID: 21914188    Free PMC article.
Role of immunotherapy for renal cell cancer in 2011.
Saby George, Roberto Pili, Michael A Carducci, Jenny J Kim.
J Natl Compr Canc Netw, 2011 Sep 16; 9(9). PMID: 21917625    Free PMC article.
Review.
Beyond cancer vaccines: a reason for future optimism with immunomodulatory therapy.
Michael Postow, Margaret K Callahan, Jedd D Wolchok.
Cancer J, 2011 Sep 29; 17(5). PMID: 21952288    Free PMC article.
Review.
The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion.
Kimberly A Hofmeyer, Hyungjun Jeon, Xingxing Zang.
J Biomed Biotechnol, 2011 Oct 01; 2011. PMID: 21960736    Free PMC article.
Review.
Programmed cell death 1 suppresses B-1b cell expansion and long-lived IgG production in response to T cell-independent type 2 antigens.
Karen M Haas.
J Immunol, 2011 Oct 18; 187(10). PMID: 22003198    Free PMC article.
Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.
Qianli Meng, Haike Guo, +3 authors, Peizeng Yang.
PLoS One, 2011 Nov 01; 6(10). PMID: 22039410    Free PMC article.
Genes, tolerance and systemic autoimmunity.
Ram P Singh, Richard T Waldron, Bevra H Hahn.
Autoimmun Rev, 2011 Dec 14; 11(9). PMID: 22155015    Free PMC article.
Review.
Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.
Dallas B Flies, Britt J Sandler, Mario Sznol, Lieping Chen.
Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180678    Free PMC article.
Review.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Oana Draghiciu, Hans W Nijman, Toos Daemen.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971    Free PMC article.
Review.
Cancer immunotherapy comes of age.
Ira Mellman, George Coukos, Glenn Dranoff.
Nature, 2011 Dec 24; 480(7378). PMID: 22193102    Free PMC article.
Highly Cited. Review.
Role of PD-1 in HIV pathogenesis and as target for therapy.
Filippos Porichis, Daniel E Kaufmann.
Curr HIV/AIDS Rep, 2011 Dec 27; 9(1). PMID: 22198819    Free PMC article.
Review.
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.
Julius Clemence R Hafalla, Carla Claser, +4 authors, Eleanor M Riley.
PLoS Pathog, 2012 Feb 10; 8(2). PMID: 22319445    Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy.
Drew Pardoll, Charles Drake.
J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682    Free PMC article.
BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis.
Yoshio Sugino, Nobuyuki Nishikawa, +6 authors, Osamu Ogawa.
Sci Rep, 2012 Mar 21; 2. PMID: 22432050    Free PMC article.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma.
Michael A Postow, James Harding, Jedd D Wolchok.
Cancer J, 2012 Mar 29; 18(2). PMID: 22453017    Free PMC article.
Review.
Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism.
Guilin Qiao, Lifen Yang, +4 authors, Jian Zhang.
Clin Immunol, 2012 Mar 31; 143(2). PMID: 22459706    Free PMC article.
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Janis M Taube, Robert A Anders, +8 authors, Lieping Chen.
Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461641    Free PMC article.
Highly Cited.
PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis.
Margarite L Tarrio, Nir Grabie, +2 authors, Andrew H Lichtman.
J Immunol, 2012 Apr 12; 188(10). PMID: 22491251    Free PMC article.
Positive and negative regulation of cellular immune responses in physiologic conditions and diseases.
S Viganò, M Perreau, G Pantaleo, A Harari.
Clin Dev Immunol, 2012 May 02; 2012. PMID: 22548114    Free PMC article.
Review.
Immunotherapy of cancer in 2012.
John M Kirkwood, Lisa H Butterfield, +3 authors, Soldano Ferrone.
CA Cancer J Clin, 2012 May 12; 62(5). PMID: 22576456    Free PMC article.
Highly Cited. Review.
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Tadashi Yokosuka, Masako Takamatsu, +3 authors, Takashi Saito.
J Exp Med, 2012 May 30; 209(6). PMID: 22641383    Free PMC article.
Highly Cited.
Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms.
Sivan Sapoznik, Ohad Hammer, +4 authors, Gal Markel.
Clin Dev Immunol, 2012 Jul 11; 2012. PMID: 22778766    Free PMC article.
Review.
Immunoregulatory molecules are master regulators of inflammation during the immune response.
Hortensia de la Fuente, Danay Cibrián, Francisco Sánchez-Madrid.
FEBS Lett, 2012 Jul 24; 586(18). PMID: 22819828    Free PMC article.
Review.
Immunotherapy for prostate cancer enters its golden age.
Sosipatros A Boikos, Emmanuel S Antonarakis.
Clin Med Insights Oncol, 2012 Jul 31; 6. PMID: 22844202    Free PMC article.
Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy.
Zhi-Chun Ding, Lei Huang, +4 authors, Gang Zhou.
Blood, 2012 Aug 04; 120(11). PMID: 22859605    Free PMC article.
Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-on-chronic liver failure.
Dayan Cao, Huan Xu, +5 authors, Yongwen Chen.
Inflammation, 2012 Aug 17; 36(1). PMID: 22895698
Role of the PD-1 pathway in the immune response.
L V Riella, A M Paterson, A H Sharpe, A Chandraker.
Am J Transplant, 2012 Aug 21; 12(10). PMID: 22900886    Free PMC article.
Highly Cited. Review.
Coinhibitory molecules in autoimmune diseases.
Norihiko Watanabe, Hiroshi Nakajima.
Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525    Free PMC article.
Review.
T-cell inhibitors: a bench-to-bedside review.
Shinjita Das, Kiyoshi Ariizumi, Ponciano D Cruz.
Dermatitis, 2012 Sep 27; 23(5). PMID: 23010825    Free PMC article.
Review.
Advances in the development of cancer immunotherapies.
Jianjun Gao, Chantale Bernatchez, +2 authors, Patrick Hwu.
Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830    Free PMC article.
Review.
Lessons learned from experimental myocarditis.
A Matsumori.
Herz, 2012 Oct 25; 37(8). PMID: 23092967
The DC-HIL ligand syndecan-4 is a negative regulator of T-cell allo-reactivity responsible for graft-versus-host disease.
Jin-Sung Chung, Mizuki Tomihari, +3 authors, Kiyoshi Ariizumi.
Immunology, 2012 Nov 02; 138(2). PMID: 23113638    Free PMC article.
Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management.
Alida L P Caforio, Renzo Marcolongo, +3 authors, S Iliceto.
Heart Fail Rev, 2012 Nov 02; 18(6). PMID: 23114995
Review.
Costimulation blockade: current perspectives and implications for therapy.
Gillian Kinnear, Nick D Jones, Kathryn J Wood.
Transplantation, 2012 Nov 07; 95(4). PMID: 23129000    Free PMC article.
Review.
Immunology beats cancer: a blueprint for successful translation.
Drew M Pardoll.
Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205    Free PMC article.
Immunotherapies: the blockade of inhibitory signals.
Yan-Ling Wu, Jing Liang, +2 authors, Hiroshi Sugiyama.
Int J Biol Sci, 2012 Dec 01; 8(10). PMID: 23197939    Free PMC article.
Review.
Immune tolerance and transplantation.
Onder Alpdogan, Marcel R M van den Brink.
Semin Oncol, 2012 Dec 05; 39(6). PMID: 23206840    Free PMC article.
Review.
Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.
Helge Frebel, Veronika Nindl, +8 authors, Annette Oxenius.
J Exp Med, 2012 Dec 12; 209(13). PMID: 23230000    Free PMC article.
Highly Cited.
Demystifying immunotherapy in prostate cancer: understanding current and future treatment strategies.
Ravi A Madan, James L Gulley, Philip W Kantoff.
Cancer J, 2013 Jan 23; 19(1). PMID: 23337757    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
SHP-1 phosphatase activity counteracts increased T cell receptor affinity.
Michael Hebeisen, Lukas Baitsch, +5 authors, Nathalie Rufer.
J Clin Invest, 2013 Feb 09; 123(3). PMID: 23391724    Free PMC article.
Structure and interactions of the human programmed cell death 1 receptor.
Xiaoxiao Cheng, Vaclav Veverka, +16 authors, Simon J Davis.
J Biol Chem, 2013 Feb 19; 288(17). PMID: 23417675    Free PMC article.
Highly Cited.
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.
Richard S Hotchkiss, Guillaume Monneret, Didier Payen.
Lancet Infect Dis, 2013 Feb 23; 13(3). PMID: 23427891    Free PMC article.
Highly Cited. Review.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.
Mario Sznol, Lieping Chen.
Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460533    Free PMC article.
Highly Cited.
The role of B-cells in heart failure.
Andrea M Cordero-Reyes, Keith A Youker, Guillermo Torre-Amione.
Methodist Debakey Cardiovasc J, 2013 Mar 23; 9(1). PMID: 23519014    Free PMC article.
Review.
Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells.
Mario Hubo, Bettina Trinschek, +3 authors, Helmut Jonuleit.
Front Immunol, 2013 Apr 09; 4. PMID: 23565116    Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
Genomics of vasculitis: lessons from mouse models.
Masato Nose, Hiroaki Komori, Tatsuhiko Miyazaki, Shiro Mori.
Ann Vasc Dis, 2013 May 04; 6(1). PMID: 23641278    Free PMC article.
PD-1 regulates T cell proliferation in a tissue and subset-specific manner during normal mouse pregnancy.
Michelle T Shepard, Elizabeth A Bonney.
Immunol Invest, 2013 Jun 21; 42(5). PMID: 23782245    Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer.
Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer.
Front Immunol, 2013 Jun 27; 4. PMID: 23801991    Free PMC article.
The heart of the matter: protection of the myocardium from T cells.
Andrew H Lichtman.
J Autoimmun, 2013 Jul 03; 45. PMID: 23810579    Free PMC article.
Review.
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.
Christopher J Nirschl, Charles G Drake.
Clin Cancer Res, 2013 Jul 23; 19(18). PMID: 23868869    Free PMC article.
Highly Cited. Review.
Dilated cardiomyopathy update: infectious-immune theory revisited.
Chuichi Kawai, Akira Matsumori.
Heart Fail Rev, 2013 Jul 31; 18(6). PMID: 23892949
Review.
B7 family checkpoint regulators in immune regulation and disease.
Sabrina Ceeraz, Elizabeth C Nowak, Randolph J Noelle.
Trends Immunol, 2013 Aug 21; 34(11). PMID: 23954143    Free PMC article.
Highly Cited. Review.
The role of interleukin-6 in the expression of PD-1 and PDL-1 on central nervous system cells following infection with Theiler's murine encephalomyelitis virus.
Young-Hee Jin, Wanqiu Hou, +2 authors, Byung S Kim.
J Virol, 2013 Aug 24; 87(21). PMID: 23966393    Free PMC article.
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response.
Yuxiang Rui, Tasuku Honjo, Shunsuke Chikuma.
Proc Natl Acad Sci U S A, 2013 Sep 18; 110(40). PMID: 24043779    Free PMC article.
Expression of programmed death-1 (PD-1) on CD4+ and CD8+ T cells in rheumatoid arthritis.
Shufeng Li, Wensheng Liao, +5 authors, Zhen Yuan.
Inflammation, 2013 Sep 26; 37(1). PMID: 24062057
Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma.
D Atanackovic, T Luetkens, N Kröger.
Leukemia, 2013 Oct 25; 28(5). PMID: 24153012
Review.
PD-1 modulates steady-state and infection-induced IL-10 production in vivo.
Cortez McBerry, Alexandra Dias, +5 authors, Julio Aliberti.
Eur J Immunol, 2013 Oct 30; 44(2). PMID: 24165808    Free PMC article.
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis.
Katherine Chang, Catherine Svabek, +11 authors, Richard Hotchkiss.
Crit Care, 2014 Jan 07; 18(1). PMID: 24387680    Free PMC article.
Highly Cited.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander".
Lucia Gelao, Carmen Criscitiello, +2 authors, Giuseppe Curigliano.
Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636    Free PMC article.
Review.
Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy.
Maxine Bauzon, Terry Hermiston.
Front Immunol, 2014 Mar 08; 5. PMID: 24605114    Free PMC article.
Review.
Immune and genetic gardening of the intestinal microbiome.
Jonathan P Jacobs, Jonathan Braun.
FEBS Lett, 2014 Mar 13; 588(22). PMID: 24613921    Free PMC article.
Review.
Fallen angels or risen apes? A tale of the intricate complexities of imbalanced immune responses in the pathogenesis and progression of immune-mediated and viral cancers.
Beatrice Omusiro Ondondo.
Front Immunol, 2014 Mar 19; 5. PMID: 24639678    Free PMC article.
Review.
Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications.
Zhixue Zheng, Zhaode Bu, +10 authors, Jiafu Ji.
Chin J Cancer Res, 2014 Mar 22; 26(1). PMID: 24653632    Free PMC article.
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.
Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641    Free PMC article.
Highly Cited.
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.
Janis M Taube, Alison Klein, +7 authors, Robert A Anders.
Clin Cancer Res, 2014 Apr 10; 20(19). PMID: 24714771    Free PMC article.
Highly Cited.
VSIG4 expression on macrophages facilitates lung cancer development.
Yunmei Liao, Sheng Guo, +6 authors, Zhihua Ruan.
Lab Invest, 2014 May 28; 94(7). PMID: 24862966
Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes.
Naoko Okiyama, Stephen I Katz.
J Autoimmun, 2014 Jul 23; 53. PMID: 25047812    Free PMC article.
PD-1 as an immune modulatory receptor.
Sheng Yao, Lieping Chen.
Cancer J, 2014 Aug 08; 20(4). PMID: 25098286    Free PMC article.
Review.
Biochemical signaling of PD-1 on T cells and its functional implications.
Vassiliki A Boussiotis, Pranam Chatterjee, Lequn Li.
Cancer J, 2014 Aug 08; 20(4). PMID: 25098287    Free PMC article.
Review.
PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence.
Scott S Tykodi.
Onco Targets Ther, 2014 Aug 13; 7. PMID: 25114573    Free PMC article.
Review.
Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus.
Steve P Crampton, Peter A Morawski, Silvia Bolland.
Dis Model Mech, 2014 Aug 26; 7(9). PMID: 25147296    Free PMC article.
Review.
Regulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological Disorders.
Shangfeng Zhao, Fengwu Li, +2 authors, Xiaoming Hu.
Front Cell Neurosci, 2014 Sep 19; 8. PMID: 25232304    Free PMC article.
Review.
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Li Wang, Isabelle Le Mercier, +7 authors, Randolph J Noelle.
Proc Natl Acad Sci U S A, 2014 Oct 01; 111(41). PMID: 25267631    Free PMC article.
Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE).
Wei Jiang, Gary Gilkeson.
J Immunother Appl, 2014 Oct 14; 1. PMID: 25309746    Free PMC article.
[Advances of PD-1/PD-L1 signaling pathway in immune escape and treatment for 
non-small cell lung cancer].
Cheng Lin, Xiong Chen, +2 authors, Xuenong Ou-Yang.
Zhongguo Fei Ai Za Zhi, 2014 Oct 25; 17(10). PMID: 25342040    Free PMC article.
Review.
Myeloid-derived suppressor cells impair alveolar macrophages through PD-1 receptor ligation during Pneumocystis pneumonia.
Guang-Sheng Lei, Chen Zhang, Chao-Hung Lee.
Infect Immun, 2014 Nov 19; 83(2). PMID: 25404033    Free PMC article.
Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Linh T Nguyen, Pamela S Ohashi.
Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622
Highly Cited. Review.
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo.
Rituparna Das, Rakesh Verma, +8 authors, Kavita M Dhodapkar.
J Immunol, 2014 Dec 30; 194(3). PMID: 25539810    Free PMC article.
Highly Cited.
Anti-programmed death receptor 1 immunotherapy in melanoma: rationale, evidence and clinical potential.
Morganna Freeman-Keller, Jeffrey S Weber.
Ther Adv Med Oncol, 2015 Jan 02; 7(1). PMID: 25553080    Free PMC article.
Review.
Immune Checkpoint Blockade in Cancer Therapy.
Michael A Postow, Margaret K Callahan, Jedd D Wolchok.
J Clin Oncol, 2015 Jan 22; 33(17). PMID: 25605845    Free PMC article.
Highly Cited. Review.
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma.
Rafael Winograd, Katelyn T Byrne, +8 authors, Robert H Vonderheide.
Cancer Immunol Res, 2015 Feb 14; 3(4). PMID: 25678581    Free PMC article.
Highly Cited.
Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.
R Fujisawa, F Haseda, +8 authors, T Hanafusa.
Clin Exp Immunol, 2015 Feb 17; 180(3). PMID: 25682896    Free PMC article.
Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis.
Lin Cheng, Xian Tang, +13 authors, Zhiwei Chen.
MAbs, 2015 Feb 19; 7(3). PMID: 25692916    Free PMC article.
IL-15 temporally reorients IL-10 biased B-1a cells toward IL-12 expression.
Amlan Kanti Ghosh, Debolina Sinha, +2 authors, Tapas Biswas.
Cell Mol Immunol, 2015 Mar 10; 13(2). PMID: 25748019    Free PMC article.
The Role of Anti-PD-1/PD-L1 Agents in Melanoma: Progress to Date.
Katy K Tsai, Adil I Daud.
Drugs, 2015 Mar 25; 75(6). PMID: 25802230
Review.
PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation.
Li Liu, Qiangsun Zheng, +3 authors, Zhiquan Wang.
J Cell Mol Med, 2015 Mar 27; 19(6). PMID: 25810125    Free PMC article.
NF-κB regulates PD-1 expression in macrophages.
Alexander P R Bally, Peiyuan Lu, +4 authors, Jeremy M Boss.
J Immunol, 2015 Mar 27; 194(9). PMID: 25810391    Free PMC article.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma.
Heinz Läubli, Cathrin Balmelli, +3 authors, Alfred Zippelius.
J Immunother Cancer, 2015 Apr 23; 3. PMID: 25901283    Free PMC article.
Highly Cited.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
Programmed death-1 controls T cell survival by regulating oxidative metabolism.
Victor Tkachev, Stefanie Goodell, +5 authors, Craig A Byersdorfer.
J Immunol, 2015 May 15; 194(12). PMID: 25972478    Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy.
Keishi Adachi, Koji Tamada.
Cancer Sci, 2015 May 20; 106(8). PMID: 25981182    Free PMC article.
Review.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Review.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study.
Hubert Kübler, Birgit Scheel, +17 authors, Arnulf Stenzl.
J Immunother Cancer, 2015 Jun 18; 3. PMID: 26082837    Free PMC article.
Inhibitory Receptors Beyond T Cell Exhaustion.
Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser.
Front Immunol, 2015 Jul 15; 6. PMID: 26167163    Free PMC article.
Highly Cited. Review.
The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review.
Si Chen, Yuan Li, +9 authors, Yongzhe Li.
Rheumatol Int, 2015 Aug 02; 36(1). PMID: 26232179
Review.
Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors.
Francesca De Felice, Claudia Marchetti, +4 authors, Pierluigi Benedetti Panici.
J Immunol Res, 2015 Aug 04; 2015. PMID: 26236750    Free PMC article.
Review.
Nivolumab in the treatment of malignant melanoma: review of the literature.
Emi Mashima, Akiha Inoue, +10 authors, Motonobu Nakamura.
Onco Targets Ther, 2015 Aug 15; 8. PMID: 26273207    Free PMC article.
Review.
Pembrolizumab.
Leila Khoja, Marcus O Butler, +2 authors, Anthony M Joshua.
J Immunother Cancer, 2015 Aug 20; 3. PMID: 26288737    Free PMC article.
Review.
Lung cancer: Biology and treatment options.
Hassan Lemjabbar-Alaoui, Omer Ui Hassan, Yi-Wei Yang, Petra Buchanan.
Biochim Biophys Acta, 2015 Aug 25; 1856(2). PMID: 26297204    Free PMC article.
Highly Cited. Review.
The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients.
Xinbing Sui, Junhong Ma, +5 authors, Li Zhang.
Oncotarget, 2015 Aug 26; 6(23). PMID: 26305724    Free PMC article.
Review.
Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses.
Karishma Rajani, Christopher Parrish, +10 authors, Richard Vile.
Mol Ther, 2015 Aug 28; 24(1). PMID: 26310630    Free PMC article.
Highly Cited.
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.
Lieping Chen, Xue Han.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325035    Free PMC article.
Highly Cited. Review.
The role of B-1 cells in inflammation.
Monowar Aziz, Nichol E Holodick, Thomas L Rothstein, Ping Wang.
Immunol Res, 2015 Oct 03; 63(1-3). PMID: 26427372    Free PMC article.
Review.
Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies.
Yi Xia, L Jeffrey Medeiros, Ken H Young.
Biochim Biophys Acta, 2015 Oct 04; 1865(1). PMID: 26432723    Free PMC article.
Review.
Human Cancer Immunotherapy with PD-1/PD-L1 Blockade.
Peilin Zheng, Zhiguang Zhou.
Biomark Cancer, 2015 Oct 09; 7(Suppl 2). PMID: 26448693    Free PMC article.
Review.
Clinical significance of programmed death ligand-1 (PD-L1) in colorectal serrated adenocarcinoma.
Hailong Zhu, Huali Qin, +6 authors, Xianghua Yi.
Int J Clin Exp Pathol, 2015 Oct 16; 8(8). PMID: 26464688    Free PMC article.
Immunotherapy and tumor microenvironment.
Haidong Tang, Jian Qiao, Yang-Xin Fu.
Cancer Lett, 2015 Oct 20; 370(1). PMID: 26477683    Free PMC article.
Highly Cited. Review.
Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy.
Mohamed L Salem, Ahmed El-Badawy.
World J Hepatol, 2015 Oct 21; 7(23). PMID: 26483866    Free PMC article.
Review.
Molecular profiling in the treatment of colorectal cancer: focus on regorafenib.
Yiyi Yan, Axel Grothey.
Onco Targets Ther, 2015 Oct 29; 8. PMID: 26508880    Free PMC article.
Review.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.
Anna Śledzińska, Laurie Menger, +2 authors, Sergio A Quezada.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451    Free PMC article.
Review.
Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways.
Cuiping Liu, Juean Jiang, +7 authors, Xueguang Zhang.
Arthritis Res Ther, 2015 Nov 27; 17. PMID: 26608464    Free PMC article.
Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery.
Andrew M Bellinger, Carlos L Arteaga, +4 authors, Javid J Moslehi.
Circulation, 2015 Dec 09; 132(23). PMID: 26644247    Free PMC article.
Review.
Synthetic RORγt Agonists Enhance Protective Immunity.
Mi Ra Chang, Venkatasubramanian Dharmarajan, +5 authors, Patrick R Griffin.
ACS Chem Biol, 2016 Jan 20; 11(4). PMID: 26785144    Free PMC article.
An increased number of PD-1+ and Tim-3+ CD8+ T cells is involved in immune evasion in gastric cancer.
Shuichi Takano, Hiroaki Saito, Masahide Ikeguchi.
Surg Today, 2016 Jan 24; 46(11). PMID: 26801344
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.
Kerstin Sarter, Elisa Leimgruber, +16 authors, Walter Reith.
J Exp Med, 2016 Jan 27; 213(2). PMID: 26809444    Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Review.
Basics of PD-1 in self-tolerance, infection, and cancer immunity.
Shunsuke Chikuma.
Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303
Review.
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
Alison Taylor, James A Harker, +3 authors, Christopher E Rudd.
Immunity, 2016 Feb 18; 44(2). PMID: 26885856    Free PMC article.
PD-1 expression conditions T cell avidity within an antigen-specific repertoire.
Sylvain Simon, Virginie Vignard, +4 authors, N Labarriere.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942093    Free PMC article.
Genetic and Epigenetic Regulation of PD-1 Expression.
Alexander P R Bally, James W Austin, Jeremy M Boss.
J Immunol, 2016 Mar 06; 196(6). PMID: 26945088    Free PMC article.
Review.
Signaling in T cells - is anything the m(a)TOR with the picture(s)?
Mark Boothby.
F1000Res, 2016 Mar 08; 5. PMID: 26949528    Free PMC article.
Review.
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.
Pushpa Jayaraman, Miye K Jacques, +6 authors, Samuel M Behar.
PLoS Pathog, 2016 Mar 12; 12(3). PMID: 26967901    Free PMC article.
Highly Cited.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade.
Haidong Tang, Yang Wang, +6 authors, Yang-Xin Fu.
Cancer Cell, 2016 Mar 16; 29(3). PMID: 26977880    Free PMC article.
Highly Cited.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy.
Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll.
Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802    Free PMC article.
Highly Cited. Review.
PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity.
Tong Seng Lim, Valerie Chew, +4 authors, Paola Ricciardi-Castagnoli.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141339    Free PMC article.
A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage.
Colette Dezutter-Dambuyant, Isabelle Durand, +10 authors, Christophe Caux.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141350    Free PMC article.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination.
Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert.
Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885
Highly Cited. Review.
Enhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy.
Jae Hun Shin, Hyung Bae Park, Kyungho Choi.
Immune Netw, 2016 May 11; 16(2). PMID: 27162530    Free PMC article.
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
Jianxun Wang, Masayuki Mizui, +7 authors, Maria I Kontaridis.
J Clin Invest, 2016 May 18; 126(6). PMID: 27183387    Free PMC article.
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Ana C Anderson, Nicole Joller, Vijay K Kuchroo.
Immunity, 2016 May 19; 44(5). PMID: 27192565    Free PMC article.
Highly Cited. Review.
Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria.
Joshua M Horne-Debets, Deshapriya S Karunarathne, +3 authors, Michelle N Wykes.
Sci Rep, 2016 May 25; 6. PMID: 27217330    Free PMC article.
PD-1 rs2227982 Polymorphism Is Associated With the Decreased Risk of Breast Cancer in Northwest Chinese Women: A Hospital-Based Observational Study.
Hong-Tao Ren, Yi-Ming Li, +9 authors, Zhi-Jun Dai.
Medicine (Baltimore), 2016 May 27; 95(21). PMID: 27227944    Free PMC article.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy.
Weijie Ma, Barbara M Gilligan, Jianda Yuan, Tianhong Li.
J Hematol Oncol, 2016 May 29; 9(1). PMID: 27234522    Free PMC article.
Highly Cited. Review.
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma.
Naoka Murakami, Thiago J Borges, Michifumi Yamashita, Leonardo V Riella.
Clin Kidney J, 2016 Jun 09; 9(3). PMID: 27274826    Free PMC article.
The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats.
Mei Tian, Yonghong Zhang, +3 authors, Aihua Liao.
Sci Rep, 2016 Jun 10; 6. PMID: 27277012    Free PMC article.
FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice.
Ferenc Boldizsar, Oktavia Tarjanyi, +4 authors, Tibor A Rauch.
Cardiovasc Pathol, 2016 Jun 12; 25(5). PMID: 27288745    Free PMC article.
Metastatic melanoma and immunotherapy.
Benjamin Herzberg, David E Fisher.
Clin Immunol, 2016 Jul 20; 172. PMID: 27430520    Free PMC article.
Review.
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer.
Robert Gibson, Jess Delaune, Anita Szady, Merry Markham.
BMJ Case Rep, 2016 Jul 22; 2016. PMID: 27440853    Free PMC article.
Emerging treatments in management of prostate cancer: biomarker validation and endpoints for immunotherapy clinical trial design.
Susan F Slovin.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27471695    Free PMC article.
Review.
Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy.
Lucie Heinzerling, Patrick A Ott, +7 authors, Jason J Luke.
J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532025    Free PMC article.
Highly Cited.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Benjamin Herzberg, Meghan J Campo, Justin F Gainor.
Oncologist, 2016 Aug 19; 22(1). PMID: 27534574    Free PMC article.
Review.
New targeted treatments for non-small-cell lung cancer - role of nivolumab.
Giulia Zago, Mirte Muller, Michel van den Heuvel, Paul Baas.
Biologics, 2016 Aug 19; 10. PMID: 27536062    Free PMC article.
Review.
T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases.
Eoin F McKinney, Kenneth Gc Smith.
Immunol Cell Biol, 2016 Sep 01; 94(10). PMID: 27577866
Review.
Varicella-Zoster Virus Downregulates Programmed Death Ligand 1 and Major Histocompatibility Complex Class I in Human Brain Vascular Adventitial Fibroblasts, Perineurial Cells, and Lung Fibroblasts.
Dallas Jones, Anna Blackmon, +4 authors, Maria A Nagel.
J Virol, 2016 Sep 16; 90(23). PMID: 27630241    Free PMC article.
Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report.
Taofeek K Owonikoko, Mukesh Kumar, +10 authors, Suresh S Ramalingam.
Cancer Immunol Immunother, 2016 Oct 25; 66(1). PMID: 27771741    Free PMC article.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Douglas B Johnson, Justin M Balko, +29 authors, Javid J Moslehi.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806233    Free PMC article.
Highly Cited.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.
Vassiliki A Boussiotis.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234    Free PMC article.
Highly Cited. Review.
Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity.
Tony T Jiang, Tijana Martinov, +4 authors, Sing Sing Way.
Cell Rep, 2016 Nov 10; 17(7). PMID: 27829150    Free PMC article.
Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy.
Maarten Swart, Inge Verbrugge, Joost B Beltman.
Front Oncol, 2016 Nov 17; 6. PMID: 27847783    Free PMC article.
Highly Cited. Review.
Immunosuppression in liver tumors: opening the portal to effective immunotherapy.
P Guha, J Reha, S C Katz.
Cancer Gene Ther, 2016 Dec 03; 24(3). PMID: 27910858
Review.
Checkpoint inhibition in myeloma.
Don M Benson.
Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913525    Free PMC article.
Review.
Immunoregulation in Fungal Diseases.
Jonathan A Roussey, Michal A Olszewski, John J Osterholzer.
Microorganisms, 2016 Dec 16; 4(4). PMID: 27973396    Free PMC article.
Review.
PD-1 and its ligands are important immune checkpoints in cancer.
Yinan Dong, Qian Sun, Xinwei Zhang.
Oncotarget, 2016 Dec 16; 8(2). PMID: 27974689    Free PMC article.
Highly Cited. Review.
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation.
Kankana Bardhan, Theodora Anagnostou, Vassiliki A Boussiotis.
Front Immunol, 2016 Dec 27; 7. PMID: 28018338    Free PMC article.
Highly Cited. Review.
Genetically engineered mouse models in oncology research and cancer medicine.
Kelly Kersten, Karin E de Visser, Martine H van Miltenburg, Jos Jonkers.
EMBO Mol Med, 2016 Dec 29; 9(2). PMID: 28028012    Free PMC article.
Highly Cited. Review.
A New VISTA on combination therapy for negative checkpoint regulator blockade.
Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle.
J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817    Free PMC article.
Review.
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Kenji Chamoto, Partha S Chowdhury, +4 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2017 Jan 18; 114(5). PMID: 28096382    Free PMC article.
Highly Cited.
Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.
Hui Zhang, Ryu Watanabe, +5 authors, Cornelia M Weyand.
Proc Natl Acad Sci U S A, 2017 Jan 25; 114(6). PMID: 28115719    Free PMC article.
Highly Cited.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka.
Blood, 2017 Feb 06; 129(15). PMID: 28151427    Free PMC article.
Highly Cited.
Renal complications of immune checkpoint blockade.
Naoka Murakami, Shveta Motwani, Leonardo V Riella.
Curr Probl Cancer, 2017 Feb 13; 41(2). PMID: 28189263    Free PMC article.
Review.
CD103+ lung dendritic cells (LDCs) induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11bhi LDCs.
Sudhanshu Shekhar, Ying Peng, Shuhe Wang, Xi Yang.
Cell Mol Immunol, 2017 Feb 15; 15(4). PMID: 28194020    Free PMC article.
Cardiovascular Toxicities Associated with Cancer Immunotherapies.
Daniel Y Wang, Gosife Donald Okoye, +2 authors, Javid J Moslehi.
Curr Cardiol Rep, 2017 Feb 22; 19(3). PMID: 28220466
Highly Cited. Review.
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer.
Andreas D Hartkopf, Florin-Andrei Taran, +4 authors, Sara Y Brucker.
Breast Care (Basel), 2017 Feb 24; 11(6). PMID: 28228704    Free PMC article.
Review.
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.
Eszter Lázár-Molnár, Lisa Scandiuzzi, +7 authors, Steven C Almo.
EBioMedicine, 2017 Feb 25; 17. PMID: 28233730    Free PMC article.
Inflammatory cytokines compromise programmed cell death-1 (PD-1)-mediated T cell suppression in inflammatory arthritis through up-regulation of soluble PD-1.
D Bommarito, C Hall, L S Taams, V M Corrigall.
Clin Exp Immunol, 2017 Mar 01; 188(3). PMID: 28245522    Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors.
Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim.
Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545    Free PMC article.
Review.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.
Liliana E Lucca, David A Hafler.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696    Free PMC article.
Review.
Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.
Leslie S Kean, Laurence A Turka, Bruce R Blazar.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258702    Free PMC article.
Review.
In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network.
Kaitao Li, Xiaoxiao Cheng, +2 authors, Cheng Zhu.
J Biol Chem, 2017 Mar 09; 292(16). PMID: 28270509    Free PMC article.
Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients.
Hui Shi, Junna Ye, +13 authors, Chengde Yang.
Arthritis Res Ther, 2017 Mar 10; 19(1). PMID: 28274252    Free PMC article.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma.
Manohan Sinnadurai, Kerrie L McDonald.
J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764
Review.
Imaging and clinicopathological features of nivolumab-related cholangitis in patients with non-small cell lung cancer.
Hisato Kawakami, Junko Tanizaki, +11 authors, Kazuhiko Nakagawa.
Invest New Drugs, 2017 Mar 21; 35(4). PMID: 28317087
Clinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients.
Takashi Nomizo, Hiroaki Ozasa, +8 authors, Young Hak Kim.
Sci Rep, 2017 Mar 24; 7. PMID: 28332580    Free PMC article.
Cancer immunotherapies targeting the PD-1 signaling pathway.
Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo.
J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884    Free PMC article.
Highly Cited. Review.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.
Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri.
Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974    Free PMC article.
Review.
The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent.
Claire Briet, Gwladys Bourdenet, +9 authors, Christian Boitard.
Front Immunol, 2017 Apr 21; 8. PMID: 28424681    Free PMC article.
Checkpoint inhibitors in hematological malignancies.
Chi Young Ok, Ken H Young.
J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851    Free PMC article.
Highly Cited. Review.
Targeting the programmed cell death-1 pathway in rheumatoid arthritis.
Sabina Sandigursky, Gregg J Silverman, Adam Mor.
Autoimmun Rev, 2017 Jun 03; 16(8). PMID: 28572054    Free PMC article.
Review.
Autoimmune Diabetes and Thyroiditis Complicating Treatment with Nivolumab.
Li Li, Awais Masood, +2 authors, Alan B Grosbach.
Case Rep Oncol, 2017 Jun 15; 10(1). PMID: 28611636    Free PMC article.
The emerging role of immune checkpoint based approaches in AML and MDS.
Prajwal Boddu, Hagop Kantarjian, +3 authors, Naval Daver.
Leuk Lymphoma, 2017 Jul 07; 59(4). PMID: 28679300    Free PMC article.
Review.
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Andrew Gibson, Lee Faulkner, +8 authors, Dean J Naisbitt.
J Immunol, 2017 Jul 09; 199(4). PMID: 28687658    Free PMC article.
Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis.
Hyosun Cho, Hyojeung Kang, Hwan Hee Lee, Chang Wook Kim.
Int J Mol Sci, 2017 Jul 14; 18(7). PMID: 28703774    Free PMC article.
Review.
Developing Cures: Targeting Ontogenesis in Cancer.
Victor T G Lin, Hawley C Pruitt, Rajeev S Samant, Lalita A Shevde.
Trends Cancer, 2017 Jul 19; 3(2). PMID: 28718443    Free PMC article.
Review.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.
Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour.
ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757    Free PMC article.
Highly Cited. Review.
Lung cancer as a cardiotoxic state: a review.
David Pérez-Callejo, María Torrente, +2 authors, Mariano Provencio.
Med Oncol, 2017 Aug 11; 34(9). PMID: 28795306
Review.
A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma.
Naoya Maekawa, Satoru Konnai, +13 authors, Kazuhiko Ohashi.
Sci Rep, 2017 Aug 23; 7(1). PMID: 28827658    Free PMC article.
The promise of immunotherapy in head and neck squamous cell carcinoma: combinatorial immunotherapy approaches.
Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri.
ESMO Open, 2017 Aug 30; 1(6). PMID: 28848660    Free PMC article.
Review.
Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40.
David J Messenheimer, Shawn M Jensen, +6 authors, Bernard A Fox.
Clin Cancer Res, 2017 Sep 01; 23(20). PMID: 28855348    Free PMC article.
Highly Cited.
Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.
Ping-Pin Zheng, Jin Li, Johan M Kros.
Med Res Rev, 2017 Sep 02; 38(1). PMID: 28862319    Free PMC article.
Review.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656    Free PMC article.
Tim-3, Lag-3, and TIGIT.
Nicole Joller, Vijay K Kuchroo.
Curr Top Microbiol Immunol, 2017 Sep 14; 410. PMID: 28900677    Free PMC article.
Review.
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Romualdo Barroso-Sousa, William T Barry, +4 authors, Sara M Tolaney.
JAMA Oncol, 2017 Oct 04; 4(2). PMID: 28973656    Free PMC article.
Highly Cited. Systematic Review.
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
Control of NK Cell Activation by Immune Checkpoint Molecules.
Asma Beldi-Ferchiou, Sophie Caillat-Zucman.
Int J Mol Sci, 2017 Oct 13; 18(10). PMID: 29023417    Free PMC article.
Review.
MAGT1-mediated disturbance of Mg2+ homeostasis lead to exhausted of HBV-infected NK and CD8+ T cells.
Bo Diao, Xiaoyong Huang, +4 authors, Yuzhang Wu.
Sci Rep, 2017 Oct 21; 7(1). PMID: 29051561    Free PMC article.
Checkpoint inhibitor-induced uveitis: a case series.
Christopher D Conrady, Marissa Larochelle, +3 authors, Ajay Singh.
Graefes Arch Clin Exp Ophthalmol, 2017 Oct 29; 256(1). PMID: 29080102
HLA-mediated tumor escape mechanisms that may impair immunotherapy clinical outcomes via T-cell activation.
Josefa A Rodríguez.
Oncol Lett, 2017 Nov 01; 14(4). PMID: 29085437    Free PMC article.
Cardiotoxicity of immune checkpoint inhibitors.
Gilda Varricchi, Maria Rosaria Galdiero, +5 authors, Carlo Gabriele Tocchetti.
ESMO Open, 2017 Nov 07; 2(4). PMID: 29104763    Free PMC article.
Highly Cited. Review.
Live Cell Labeling with Terpyridine Derivative Proligands to Measure Cytotoxicity Mediated by Immune Cells.
Yuki Sakai, Satoshi Mizuta, +5 authors, Yoshimasa Tanaka.
ChemMedChem, 2017 Nov 08; 12(23). PMID: 29110403    Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
Review.
PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective.
Palanisamy Nallasamy, Srinivas Chava, +7 authors, Kishore B Challagundla.
Semin Cancer Biol, 2017 Dec 03; 52(Pt 2). PMID: 29196189    Free PMC article.
Review.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy.
Robert J Torphy, Richard D Schulick, Yuwen Zhu.
Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042    Free PMC article.
Review.
PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease.
Kathryn W Juchem, Faruk Sacirbegovic, +6 authors, Warren D Shlomchik.
J Immunol, 2017 Dec 08; 200(2). PMID: 29212909    Free PMC article.
Investigational PD-1 inhibitors in HL and NHL and biomarkers for predictors of response and outcome.
Andres Chang, Danielle Schlafer, Christopher R Flowers, Pamela B Allen.
Expert Opin Investig Drugs, 2017 Dec 13; 27(1). PMID: 29228840    Free PMC article.
Review.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young.
Front Immunol, 2017 Dec 20; 8. PMID: 29255458    Free PMC article.
Highly Cited. Review.
Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma.
Hassan Sadozai, Thomas Gruber, Robert Emil Hunger, Mirjam Schenk.
Front Immunol, 2017 Dec 26; 8. PMID: 29276510    Free PMC article.
Review.
Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.
Michael Peled, Anna S Tocheva, +10 authors, Adam Mor.
Proc Natl Acad Sci U S A, 2017 Dec 29; 115(3). PMID: 29282323    Free PMC article.
Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade.
Jie Bai, Zhitao Gao, +3 authors, Jing Nie.
Oncotarget, 2018 Jan 05; 8(66). PMID: 29299180    Free PMC article.
Review.
The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.
Stefan Frantz, Ines Falcao-Pires, +16 authors, Stephane Heymans.
Eur J Heart Fail, 2018 Jan 16; 20(3). PMID: 29333691    Free PMC article.
Highly Cited. Review.
Clinical Development of PD-1 in Advanced Melanoma.
Rodrigo Ramella Munhoz, Michael Andrew Postow.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360722    Free PMC article.
Review.
Inhibition of the checkpoint protein PD-1 by the therapeutic antibody pembrolizumab outlined by quantum chemistry.
Ana Beatriz M L A Tavares, José X Lima Neto, Umberto L Fulco, Eudenilson L Albuquerque.
Sci Rep, 2018 Feb 01; 8(1). PMID: 29382901    Free PMC article.
Multifunctional nanoparticles for cancer immunotherapy: A groundbreaking approach for reprogramming malfunctioned tumor environment.
Samaresh Sau, Hashem O Alsaab, +3 authors, Arun K Iyer.
J Control Release, 2018 Feb 03; 274. PMID: 29391232    Free PMC article.
Highly Cited. Review.
Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies.
Danuta J Herzyk, Helen G Haggerty.
AAPS J, 2018 Feb 09; 20(2). PMID: 29417397
Review.
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.
Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng.
Cell Res, 2018 Feb 22; 28(4). PMID: 29463898    Free PMC article.
Highly Cited.
PD-1 is required to maintain stem cell properties in human dental pulp stem cells.
Yao Liu, Huan Jing, +5 authors, Songtao Shi.
Cell Death Differ, 2018 Feb 24; 25(7). PMID: 29472716    Free PMC article.
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.
Yanxia Guo, Alice M Walsh, +18 authors, Sunil Nagpal.
PLoS One, 2018 Mar 01; 13(2). PMID: 29489833    Free PMC article.
Highly Cited.
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells.
Thomas Menter, Alexandar Tzankov.
Front Oncol, 2018 Mar 23; 8. PMID: 29564225    Free PMC article.
Review.
Serial Troponin for Early Detection of Nivolumab Cardiotoxicity in Advanced Non-Small Cell Lung Cancer Patients.
Matteo Sarocchi, Francesco Grossi, +12 authors, Paolo Spallarossa.
Oncologist, 2018 Mar 24; 23(8). PMID: 29567824    Free PMC article.
Evaluation of programmed cell death protein 1 (PD-1) expression as a prognostic biomarker in patients with clear cell renal cell carcinoma.
Kyu Seo Kim, Rishi R Sekar, +5 authors, Viraj A Master.
Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632730    Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Electrophysiologic Toxicity of Chemoradiation.
Merna A Armanious, Shreya Mishra, Michael G Fradley.
Curr Oncol Rep, 2018 Apr 13; 20(6). PMID: 29644475
Review.
Cardiotoxicity of Immunotherapy: Incidence, Diagnosis, and Management.
Aarti Asnani.
Curr Oncol Rep, 2018 Apr 13; 20(6). PMID: 29644505
Review.
The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?
Laura de Ramon, Jordi Guiteras, +3 authors, Juan Torras.
Int J Mol Sci, 2018 Apr 26; 19(5). PMID: 29693595    Free PMC article.
Review.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673    Free PMC article.
Review.
Immune checkpoint receptors: homeostatic regulators of immunity.
Antonio Riva, Shilpa Chokshi.
Hepatol Int, 2018 May 10; 12(3). PMID: 29740793    Free PMC article.
Review.
T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Elizabeth F Wallin.
Transplantation, 2018 May 15; 102(10). PMID: 29757907    Free PMC article.
Review.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
Review.
Immune Checkpoint Inhibitor-Associated Myocarditis.
Sarju Ganatra, Tomas G Neilan.
Oncologist, 2018 May 29; 23(8). PMID: 29802219    Free PMC article.
Highly Cited.
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Kevin C Osum, Adam L Burrack, +8 authors, Brian T Fife.
Sci Rep, 2018 May 31; 8(1). PMID: 29844327    Free PMC article.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses.
Teresa Nguyen, Naze G Avci, +2 authors, Hong Jiang.
Cancers (Basel), 2018 Jun 03; 10(6). PMID: 29857493    Free PMC article.
Review.
Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens.
Mengjia Song, Xinfeng Chen, Liping Wang, Yi Zhang.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861603    Free PMC article.
Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis.
Heidi Harjunpää, Stephen J Blake, +12 authors, Michele W L Teng.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900061    Free PMC article.
Proliferative CD8(+) PD-1(+) T-cell infiltration in a pembrolizumab-induced cutaneous adverse reaction.
Kei Kunimasa, Taiki Isei, +9 authors, Fumio Imamura.
Invest New Drugs, 2018 Jun 28; 36(6). PMID: 29947012
Clinicopathological value of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) expression in synovium of patients with rheumatoid arthritis.
Kotaro Matsuda, Hiroaki Miyoshi, +6 authors, Koichi Ohshima.
Clin Exp Med, 2018 Jul 02; 18(4). PMID: 29961175
Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity.
Jiu-Cheng Zhang, Wei-Dong Chen, +6 authors, Hua Zhu.
Acta Pharmacol Sin, 2018 Jul 12; 39(11). PMID: 29991709    Free PMC article.
Review.
Microbial biomarkers for immune checkpoint blockade therapy against cancer.
Keishi Adachi, Koji Tamada.
J Gastroenterol, 2018 Jul 14; 53(9). PMID: 30003334    Free PMC article.
Review.
Coronary Toxicities of Anti-PD-1 and Anti-PD-L1 Immunotherapies: a Case Report and Review of the Literature and International Registries.
Marion Ferreira, Eric Pichon, +6 authors, Sylvain Marchand-Adam.
Target Oncol, 2018 Jul 15; 13(4). PMID: 30006825
Review.
Regulatory Role of CD4+ T Cells in Myocarditis.
Daria Vdovenko, Urs Eriksson.
J Immunol Res, 2018 Jul 24; 2018. PMID: 30035131    Free PMC article.
Review.
Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation.
Yuli Cheng, Xing Zhu, +6 authors, Xinping Zhu.
Front Immunol, 2018 Aug 11; 9. PMID: 30093899    Free PMC article.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.
Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül.
Front Immunol, 2018 Aug 31; 9. PMID: 30158932    Free PMC article.
Review.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
Review.
Combining immunotherapy with radiation therapy in thoracic oncology.
Shahed N Badiyan, Michael C Roach, +7 authors, Charles B Simone.
J Thorac Dis, 2018 Sep 13; 10(Suppl 21). PMID: 30206494    Free PMC article.
Review.
Mechanism and Management of Cancer Chemotherapy-Induced Atherosclerosis.
Mikio Mukai, Keiko Komori, Toru Oka.
J Atheroscler Thromb, 2018 Sep 19; 25(10). PMID: 30224607    Free PMC article.
Review.
Not All Immune Checkpoints Are Created Equal.
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger.
Front Immunol, 2018 Sep 21; 9. PMID: 30233564    Free PMC article.
Highly Cited. Review.
EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity.
Michael Peled, Matthew A Dragovich, +4 authors, Adam Mor.
J Immunol, 2018 Oct 03; 201(9). PMID: 30275048    Free PMC article.
Immune Checkpoints as Therapeutic Targets in Autoimmunity.
Christopher Paluch, Ana Mafalda Santos, +2 authors, Simon J Davis.
Front Immunol, 2018 Oct 24; 9. PMID: 30349540    Free PMC article.
Review.
Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again.
Samantha L Bucktrout, Jeffrey A Bluestone, Fred Ramsdell.
Genome Med, 2018 Nov 01; 10(1). PMID: 30376867    Free PMC article.
Review.
Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells.
Suresh Pallikkuth, Rajendra Pahwa, +9 authors, Savita Pahwa.
PLoS One, 2018 Nov 01; 13(10). PMID: 30379878    Free PMC article.
Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression.
Elena Gianchecchi, Alessandra Fierabracci.
Front Immunol, 2018 Nov 06; 9. PMID: 30386337    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Inhibitor-Related Cardiotoxicity.
Barry Trachtenberg, Fahd Hussain, +2 authors, Sai Ravi Kiran Pingali.
Methodist Debakey Cardiovasc J, 2018 Nov 10; 14(3). PMID: 30410661    Free PMC article.
The Central Role of Inflammation Associated with Checkpoint Inhibitor Treatments.
Cristina Vajaitu, Carmen Cristina Draghici, +6 authors, Vlad Mihai Voiculescu.
J Immunol Res, 2018 Nov 13; 2018. PMID: 30417020    Free PMC article.
Review.
Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study.
Joe-Elie Salem, Ali Manouchehri, +10 authors, Javid J Moslehi.
Lancet Oncol, 2018 Nov 18; 19(12). PMID: 30442497    Free PMC article.
Highly Cited.
The Role of Leukocytes in Diabetic Cardiomyopathy.
Anamika Bajpai, Douglas G Tilley.
Front Physiol, 2018 Nov 18; 9. PMID: 30443223    Free PMC article.
Review.
Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia.
Koutaro Takamatsu, Shunya Nakane, +11 authors, Yukio Ando.
Ann Clin Transl Neurol, 2018 Nov 28; 5(11). PMID: 30480036    Free PMC article.
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
Jianqin Lu, Xiangsheng Liu, +6 authors, Andre E Nel.
ACS Nano, 2018 Nov 30; 12(11). PMID: 30481959    Free PMC article.
The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy.
Arabella Young, Zoe Quandt, Jeffrey A Bluestone.
Cancer Immunol Res, 2018 Dec 05; 6(12). PMID: 30510057    Free PMC article.
Review.
Targeting tumor cells with antibodies enhances anti-tumor immunity.
Zhichen Sun, Yang-Xin Fu, Hua Peng.
Biophys Rep, 2018 Dec 12; 4(5). PMID: 30533489    Free PMC article.
Synthesis and Immunomodulatory Activity of Fluorine-Containing Bisphosphonates.
Satoshi Mizuta, Mohammed S O Tagod, +5 authors, Yoshimasa Tanaka.
ChemMedChem, 2019 Jan 15; 14(4). PMID: 30637982    Free PMC article.
Application of PD-1 Blockade in Cancer Immunotherapy.
Xiaomo Wu, Zhongkai Gu, +4 authors, Xiaolong Liu.
Comput Struct Biotechnol J, 2019 Jun 18; 17. PMID: 31205619    Free PMC article.
Highly Cited. Review.
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease.
Dominic P Del Re, Dulguun Amgalan, +2 authors, Richard N Kitsis.
Physiol Rev, 2019 Aug 01; 99(4). PMID: 31364924    Free PMC article.
Review.
Cardiac troponin I autoantibody induces myocardial dysfunction by PTEN signaling activation.
Yu Wu, Yang-Hua Qin, +6 authors, Qian Shen.
EBioMedicine, 2019 Sep 03; 47. PMID: 31474552    Free PMC article.
Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance.
Georgia Fousteri, Amy Dave Jhatakia.
Viruses, 2019 Sep 25; 11(10). PMID: 31546586    Free PMC article.
Review.
Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure.
Patricia van den Hoogen, Saskia C A de Jager, +10 authors, Joost P G Sluijter.
J Cell Mol Med, 2019 Sep 27; 23(11). PMID: 31557411    Free PMC article.
Design and application of oral colon administration system.
Hao Cheng, Shiyu Huang, Gangliang Huang.
J Enzyme Inhib Med Chem, 2019 Oct 05; 34(1). PMID: 31581863    Free PMC article.
Review.
A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer.
Xi Li, Rouzheng Wang, +25 authors, Tao Dong.
Front Oncol, 2019 Nov 12; 9. PMID: 31709176    Free PMC article.
Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells.
Kankana Bardhan, Halil-Ibrahim Aksoylar, +6 authors, Vassiliki A Boussiotis.
Sci Rep, 2019 Nov 23; 9(1). PMID: 31754127    Free PMC article.
Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway.
Grace Wakabayashi, Yu-Ching Lee, +3 authors, Yun Yen.
J Biomed Sci, 2019 Dec 06; 26(1). PMID: 31801525    Free PMC article.
Review.
Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors.
Sophia C Weinmann, David S Pisetsky.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816080    Free PMC article.
Review.
Toxicities associated with checkpoint inhibitors-an overview.
Laura Spiers, Nicholas Coupe, Miranda Payne.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816085    Free PMC article.
Review.
Immune Checkpoint Inhibitor-Associated Cardiotoxicity: Current Understanding on Its Mechanism, Diagnosis and Management.
Yu-Wen Zhou, Ya-Juan Zhu, +6 authors, Ji-Yan Liu.
Front Pharmacol, 2019 Dec 19; 10. PMID: 31849640    Free PMC article.
Review.
Combined induction with anti-PD-1 and anti-CTLA-4 antibodies provides synergistic antitumor effects in DC-CIK cells in renal carcinoma cell lines.
Zhaohu Yuan, Huikuan Yang, Yaming Wei.
Int J Clin Exp Pathol, 2020 Jan 15; 12(1). PMID: 31933726    Free PMC article.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Florian Wiede, Kun-Hui Lu, +16 authors, Tony Tiganis.
EMBO J, 2019 Dec 06; 39(2). PMID: 31803974    Free PMC article.
Odds ratio of programmed cell death-1 or ligand 1 inhibitor-related endocrine dysfunction in patients with lung cancer: A systematic review and meta-analysis.
Jian Xie, Zewen Zhang, +4 authors, Yuan Tian.
Medicine (Baltimore), 2019 Dec 20; 98(50). PMID: 31852114    Free PMC article.
Systematic Review.
Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy.
Steven L Highfill, Yongzhi Cui, +5 authors, Crystal L Mackall.
Sci Transl Med, 2014 May 23; 6(237). PMID: 24848257    Free PMC article.
Highly Cited.
Prevalence of programmed death-1 ligand-1 (PD-L1) and infiltrating lymphocytes in human gastric carcinogenesis.
Zhonghua Liu, Yufang Wang, +3 authors, Tao Wang.
Int J Clin Exp Pathol, 2017 Dec 01; 10(12). PMID: 31966537    Free PMC article.
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Tijana Martinov, Brian T Fife.
Ann N Y Acad Sci, 2019 Apr 27; 1461(1). PMID: 31025378    Free PMC article.
Review.
Recent advances in cardio-oncology: a report from the 'Heart Failure Association 2019 and World Congress on Acute Heart Failure 2019'.
Markus S Anker, Sara Hadzibegovic, +15 authors, Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology.
ESC Heart Fail, 2019 Dec 31; 6(6). PMID: 31884717    Free PMC article.
Inter-tumor heterogeneity of PD-L1 expression in non-small cell lung cancer.
Yuichi Saito, Sho Horiuchi, +5 authors, Eishin Hoshi.
J Thorac Dis, 2020 Feb 08; 11(12). PMID: 32030214    Free PMC article.
Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block.
Alisha Khan, Sana Riaz, Robert Carhart.
Case Rep Cardiol, 2020 Feb 13; 2020. PMID: 32047674    Free PMC article.
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Nicolas Palaskas, Juan Lopez-Mattei, +2 authors, Anita Deswal.
J Am Heart Assoc, 2020 Jan 22; 9(2). PMID: 31960755    Free PMC article.
Review.
T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy.
Pamela D Winterberg, Jennifer M Robertson, +2 authors, Mandy L Ford.
J Am Soc Nephrol, 2019 Feb 08;. PMID: 30728178    Free PMC article.
Structure and Optimization of Checkpoint Inhibitors.
Sarah L Picardo, Jeffrey Doi, Aaron R Hansen.
Cancers (Basel), 2019 Dec 28; 12(1). PMID: 31877721    Free PMC article.
Review.
Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis.
Laura C Cappelli, Mekha A Thomas, +2 authors, Erika Darrah.
Immunol Rev, 2020 Jan 14; 294(1). PMID: 31930524    Free PMC article.
Review.
The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.
Katrin Neumann, Annett Ostmann, +5 authors, Gisa Tiegs.
Sci Rep, 2019 Feb 16; 9(1). PMID: 30765734    Free PMC article.
Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance.
Radhika R Gudi, Subha Karumuthil-Melethil, +2 authors, Chenthamarakshan Vasu.
Sci Rep, 2019 Aug 21; 9(1). PMID: 31427630    Free PMC article.
Late cardiac adverse events in patients with cancer treated with immune checkpoint inhibitors.
Charles Dolladille, Stephane Ederhy, +10 authors, Joachim Alexandre.
J Immunother Cancer, 2020 Jan 29; 8(1). PMID: 31988143    Free PMC article.
A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma.
Y Cai, Fei Wang, +3 authors, Z Sun.
Invest New Drugs, 2018 Oct 29; 37(5). PMID: 30368626
Roles, function and relevance of LAG3 in HIV infection.
Colin G Graydon, Allison L Balasko, Keith R Fowke.
PLoS Pathog, 2019 Jan 18; 15(1). PMID: 30653605    Free PMC article.
Review.
Cardiovascular toxicities associated with immune checkpoint inhibitors.
Jiun-Ruey Hu, Roberta Florido, +7 authors, Javid Moslehi.
Cardiovasc Res, 2019 Feb 05; 115(5). PMID: 30715219    Free PMC article.
Highly Cited. Review.
T cell checkpoint regulators in the heart.
Nir Grabie, Andrew H Lichtman, Robert Padera.
Cardiovasc Res, 2019 Feb 06; 115(5). PMID: 30721928    Free PMC article.
Review.
Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients.
Silvia Medina, Susana Sainz de la Maza, +9 authors, Luisa M Villar.
Ann Clin Transl Neurol, 2019 Mar 09; 6(2). PMID: 30847367    Free PMC article.
Diabetes mellitus secondary to treatment with immune checkpoint inhibitors.
V Venetsanaki, A Boutis, A Chrisoulidou, P Papakotoulas.
Curr Oncol, 2019 Mar 12; 26(1). PMID: 30853817    Free PMC article.
Cat and Mouse: HIV Transcription in Latency, Immune Evasion and Cure/Remission Strategies.
Aurélie Delannoy, Mikaël Poirier, Brendan Bell.
Viruses, 2019 Mar 21; 11(3). PMID: 30889861    Free PMC article.
Review.
Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.
Yu Fujita, Roberto Tinoco, +2 authors, Ze'ev A Ronai.
Trends Mol Med, 2019 Mar 23; 25(5). PMID: 30898473    Free PMC article.
Review.
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Spencer C Wei, Roshan Sharma, +8 authors, James P Allison.
Immunity, 2019 Mar 31; 50(4). PMID: 30926234    Free PMC article.
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance.
Günther Schönrich, Martin J Raftery.
Front Cell Infect Microbiol, 2019 Jul 03; 9. PMID: 31263684    Free PMC article.
Highly Cited. Review.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges.
Kei Kunimasa, Taichiro Goto.
Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413    Free PMC article.
Review.
Clinical Characteristics and Treatment of Immune-Related Adverse Events of Immune Checkpoint Inhibitors.
Juwhan Choi, Sung Yong Lee.
Immune Netw, 2020 Mar 12; 20(1). PMID: 32158597    Free PMC article.
Review.
Adaptive immune cells in calcific aortic valve disease.
Michael A Raddatz, Meena S Madhur, W David Merryman.
Am J Physiol Heart Circ Physiol, 2019 May 06; 317(1). PMID: 31050556    Free PMC article.
Review.
Personalized Approach to Cancer Treatment-Related Cardiomyopathy.
Jeremy Slivnick, Ajay Vallakati, +2 authors, Matthew S Tong.
Curr Heart Fail Rep, 2020 Mar 04; 17(2). PMID: 32125627    Free PMC article.
Review.
Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes.
Tijana Martinov, Linnea A Swanson, +10 authors, Brian T Fife.
J Immunol, 2019 Jul 22; 203(4). PMID: 31324724    Free PMC article.
Relationship between Overall Survival and Response or Progression-Free Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with Anti-PD-1/PD-L1 Antibodies.
Takehito Shukuya, Keita Mori, +5 authors, David P Carbone.
J Thorac Oncol, 2016 Oct 25; 11(11). PMID: 27496650    Free PMC article.
Dilated cardiomyopathy.
Heinz-Peter Schultheiss, DeLisa Fairweather, +8 authors, Silvia G Priori.
Nat Rev Dis Primers, 2019 May 11; 5(1). PMID: 31073128    Free PMC article.
Highly Cited. Review.
Unanticipated Myocarditis in a Surgical Patient Treated With Pembrolizumab: A Case Report.
Ryan T Nierstedt, Rubaya Yeahia, Kara M Barnett.
A A Pract, 2020 Mar 07; 14(6). PMID: 32132361    Free PMC article.
Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits.
Verónica C Martínez Allo, Vanesa Hauk, +18 authors, Marta A Toscano.
Proc Natl Acad Sci U S A, 2020 Mar 13; 117(12). PMID: 32161138    Free PMC article.
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.
Alexandra Schnell, Lloyd Bod, Asaf Madi, Vijay K Kuchroo.
Cell Res, 2020 Jan 25; 30(4). PMID: 31974523    Free PMC article.
Review.
Development of immune checkpoint therapy for cancer.
Jill M Fritz, Michael J Lenardo.
J Exp Med, 2019 May 10; 216(6). PMID: 31068379    Free PMC article.
Highly Cited. Review.
PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.
Reina Mizuno, Daisuke Sugiura, +4 authors, Taku Okazaki.
Front Immunol, 2019 Apr 20; 10. PMID: 31001256    Free PMC article.
The Role of PD-1 in Acute and Chronic Infection.
Jil M Jubel, Zachary R Barbati, +2 authors, Frank A Schildberg.
Front Immunol, 2020 Apr 09; 11. PMID: 32265932    Free PMC article.
Review.
CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival.
Huazhen Liu, Feifei Qiu, +7 authors, Zhenhua Dai.
Front Immunol, 2019 Mar 14; 10. PMID: 30863408    Free PMC article.
MicroRNAs in Cancer Treatment-Induced Cardiotoxicity.
Laura Pellegrini, Sara Sileno, +6 authors, Alessandra Magenta.
Cancers (Basel), 2020 Mar 21; 12(3). PMID: 32192047    Free PMC article.
Review.
Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis.
Iris Lavon, Coral Heli, +2 authors, Adi Vaknin-Dembinsky.
Front Immunol, 2019 May 28; 10. PMID: 31134049    Free PMC article.
TIGIT as an emerging immune checkpoint.
H Harjunpää, C Guillerey.
Clin Exp Immunol, 2019 Dec 13; 200(2). PMID: 31828774    Free PMC article.
Review.
HX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic properties.
Jibin Zhang, Ying Huang, Gan Xi, Faming Zhang.
MAbs, 2020 Feb 29; 12(1). PMID: 32106752    Free PMC article.
The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PD-L1 levels on CNS cells.
Camille L Pittet, Jia Newcombe, Jack P Antel, Nathalie Arbour.
Glia, 2011 Mar 02; 59(5). PMID: 21360758    Free PMC article.
Predictive Markers for the Efficacy of Anti-PD-1/PD-L1 Antibodies in Lung Cancer.
Takehito Shukuya, David P Carbone.
J Thorac Oncol, 2016 Mar 06; 11(7). PMID: 26944305    Free PMC article.
Highly Cited. Review.
Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro.
Woan Ting Tay, Yi-Hsien Fang, +4 authors, Ping-Yen Liu.
Int J Mol Sci, 2020 Apr 05; 21(7). PMID: 32244307    Free PMC article.
Lymphocytic subsets play distinct roles in heart diseases.
Jing Wang, Yi Duan, Joost Pg Sluijter, Junjie Xiao.
Theranostics, 2019 Jul 10; 9(14). PMID: 31281530    Free PMC article.
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Current issues and perspectives in PD-1 blockade cancer immunotherapy.
Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo.
Int J Clin Oncol, 2020 Jan 05; 25(5). PMID: 31900651    Free PMC article.
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Cancer-induced immunosuppression can enable effectiveness of immunotherapy through bistability generation: A mathematical and computational examination.
Victor Garcia, Sebastian Bonhoeffer, Feng Fu.
J Theor Biol, 2020 Feb 10; 492. PMID: 32035826    Free PMC article.
Combination Strategies for Immune-Checkpoint Blockade and Response Prediction by Artificial Intelligence.
Florian Huemer, Michael Leisch, +4 authors, Richard Greil.
Int J Mol Sci, 2020 Apr 25; 21(8). PMID: 32325898    Free PMC article.
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A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
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PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
Xiaozheng Xu, Bowen Hou, +10 authors, Enfu Hui.
J Cell Biol, 2020 May 22; 219(6). PMID: 32437509    Free PMC article.
Retrospective Study of Intercalated Disk Defects Associated with Dilated Cardiomyopathy, Atrial Thrombosis, and Heart Failure in BALB/c Mice Deficient in IL4 Receptor α.
Alfonso S Gozalo, Patricia M Zerfas, William R Elkins, Richard L Gieseck.
Comp Med, 2020 May 10; 70(3). PMID: 32384942    Free PMC article.
Adjuvant Effect of Toll-Like Receptor 9 Activation on Cancer Immunotherapy Using Checkpoint Blockade.
Yu-Chen Chuang, Jen-Chih Tseng, +3 authors, Tsung-Hsien Chuang.
Front Immunol, 2020 Jun 18; 11. PMID: 32547560    Free PMC article.
Review.
From Molecular Mechanisms to Clinical Management of Antineoplastic Drug-Induced Cardiovascular Toxicity: A Translational Overview.
Carlo Gabriele Tocchetti, Christian Cadeddu, +12 authors, Giuseppe Mercuro.
Antioxid Redox Signal, 2017 Apr 12; 30(18). PMID: 28398124    Free PMC article.
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Implications of the HDAC6-ERK1 feed-forward loop in immunotherapy.
Jheng-Yu Wu, Niko Moses, Wenlong Bai, Xiaohong Mary Zhang.
J Immunol Sci, 2018 Jan 01; 2(3). PMID: 30854521    Free PMC article.
TIM3 comes of age as an inhibitory receptor.
Yochai Wolf, Ana C Anderson, Vijay K Kuchroo.
Nat Rev Immunol, 2019 Nov 05; 20(3). PMID: 31676858    Free PMC article.
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Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression.
Lalit Batra, Pradeep Shrestha, +9 authors, Esma S Yolcu.
J Immunol, 2020 Apr 08; 204(10). PMID: 32253240    Free PMC article.
PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond.
Yasumasa Ishida.
Cells, 2020 Jun 05; 9(6). PMID: 32492969    Free PMC article.
Review.
Combining protein arginine methyltransferase inhibitor and anti-programmed death-ligand-1 inhibits pancreatic cancer progression.
Nan-Nan Zheng, Min Zhou, +5 authors, Lei-Ming Xu.
World J Gastroenterol, 2020 Aug 11; 26(26). PMID: 32774054    Free PMC article.
Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells.
Daisuke Okuno, Yuki Sugiura, +11 authors, Hiroshi Mukae.
Front Immunol, 2020 Aug 15; 11. PMID: 32793196    Free PMC article.
Cardiovascular Complications of Novel Anti-Cancer Immunotherapy: Old Problems from New Agents?
Woo Baek Chung, Jong Chan Youn, Ho Joong Youn.
Korean Circ J, 2020 Jul 30; 50(9). PMID: 32725983    Free PMC article.
Review.
Evolving insights into the mechanisms of toxicity associated with immune checkpoint inhibitor therapy.
Brendan L Mangan, Renee K McAlister, +4 authors, Elizabeth J Phillips.
Br J Clin Pharmacol, 2020 Jun 17; 86(9). PMID: 32543711    Free PMC article.
Review.
Incidence of Pericardial Effusion in Patients with Advanced Non-Small Cell Lung Cancer Receiving Immunotherapy.
Maria Laura Canale, Andrea Camerini, +9 authors, Nicola Maurea.
Adv Ther, 2020 May 22; 37(7). PMID: 32436027    Free PMC article.
Development of Severe Heart Failure in a Patient with Squamous Non-small-cell Lung Cancer During Nivolumab Treatment.
Yumiko Samejima, Atsuhiko Iuchi, +11 authors, Tomonori Hirashima.
Intern Med, 2020 May 26; 59(16). PMID: 32448839    Free PMC article.
Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes.
Marika Falcone, Georgia Fousteri.
Front Endocrinol (Lausanne), 2020 Sep 26; 11. PMID: 32973682    Free PMC article.
Review.
Immune checkpoint therapy and type 1 diabetes.
Hiroshi Ikegami, Yumiko Kawabata, Shinsuke Noso.
Diabetol Int, 2016 Jul 05; 7(3). PMID: 30603267    Free PMC article.
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28.
Leonardo Chicaybam, Prasad S Adusumilli.
Transl Cancer Res, 2017 Aug 01; 6(Suppl 6). PMID: 30613486    Free PMC article.
Transforming of the Tumor Microenvironment: Implications for TGF-β Inhibition in the Context of Immune-Checkpoint Therapy.
Stefanie Löffek.
J Oncol, 2019 Jan 12; 2018. PMID: 30631358    Free PMC article.
Review.
Biomarkers for the detection of apparent and subclinical cancer therapy-related cardiotoxicity.
Lars Michel, Tienush Rassaf, Matthias Totzeck.
J Thorac Dis, 2019 Feb 01; 10(Suppl 35). PMID: 30701097    Free PMC article.
Highly Cited. Review.
Heart failure in cancer: role of checkpoint inhibitors.
Murilo Delgobo, Stefan Frantz.
J Thorac Dis, 2019 Feb 01; 10(Suppl 35). PMID: 30701100    Free PMC article.
Review.
Cardio-toxicity of checkpoint inhibitors.
Oliver J Müller, Martina E Spehlmann, Norbert Frey.
J Thorac Dis, 2019 Feb 01; 10(Suppl 35). PMID: 30701107    Free PMC article.
Review.
Cardiac Complications in Immune Checkpoint Inhibition Therapy.
Kazuko Tajiri, Masaki Ieda.
Front Cardiovasc Med, 2019 Feb 08; 6. PMID: 30729114    Free PMC article.
Review.
Risk and incidence of fatal adverse events associated with immune checkpoint inhibitors: a systematic review and meta-analysis.
Yi Jiang, Ning Zhang, +2 authors, Helong Zhang.
Ther Clin Risk Manag, 2019 Mar 13; 15. PMID: 30858709    Free PMC article.
Managing cardiotoxicity associated with immune checkpoint inhibitors.
Sireesha Upadhrasta, Hadi Elias, Keval Patel, Lei Zheng.
Chronic Dis Transl Med, 2019 Apr 18; 5(1). PMID: 30993259    Free PMC article.
Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: Case Series and Review of the Literature.
Nikhil Agrawal, Arjun Khunger, +7 authors, Igor Puzanov.
Case Rep Oncol, 2019 Apr 24; 12(1). PMID: 31011325    Free PMC article.
A Case of Acute Heart Failure due to Immune Checkpoint Blocker Nivolumab.
Munish Sharma, Giselle A Suero-Abreu, Bernard Kim.
Cardiol Res, 2019 Apr 26; 10(2). PMID: 31019642    Free PMC article.
Sequential Blockade of PD-1 and PD-L1 Causes Fulminant Cardiotoxicity-From Case Report to Mouse Model Validation.
Shin-Yi Liu, Wen-Chien Huang, +5 authors, Yu-Jen Chen.
Cancers (Basel), 2019 Apr 27; 11(4). PMID: 31022941    Free PMC article.
Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report.
Takashi Sakai, Kazuyuki Yahagi, +4 authors, Shingo Ikeda.
Respir Med Case Rep, 2019 Apr 27; 27. PMID: 31024792    Free PMC article.
Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.
Daniele Lecis, Sabina Sangaletti, Mario P Colombo, Claudia Chiodoni.
Cancers (Basel), 2019 May 08; 11(5). PMID: 31060225    Free PMC article.
Review.
Incidence risk of PD-1/PD-L1 related diarrhea in non-small cell lung cancer (NSCLC) patients: a systematic review and meta-analysis.
Caiqing Zhang, Shuisheng Zhang, +5 authors, Yuan Tian.
Cancer Manag Res, 2019 May 24; 11. PMID: 31118808    Free PMC article.
Myocarditis in Humans and in Experimental Animal Models.
Przemysław Błyszczuk.
Front Cardiovasc Med, 2019 Jun 04; 6. PMID: 31157241    Free PMC article.
Review.
Cardiotoxicity of Immune Checkpoint Inhibitors.
Lili Zhang, Maeve Jones-O'Connor, +6 authors, Tomas G Neilan.
Curr Treat Options Cardiovasc Med, 2019 Jun 09; 21(7). PMID: 31175469
Review.
Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients.
Alessandra Cuomo, Alessio Rodolico, +10 authors, Valentina Mercurio.
Card Fail Rev, 2019 Jun 11; 5(2). PMID: 31179022    Free PMC article.
Review.
Cardiac toxicity of immune-checkpoint inhibitors: a clinical case of nivolumab-induced myocarditis and review of the evidence and new challenges.
Roberto Martin Huertas, Cristina Saavedra Serrano, +2 authors, Teresa Alonso Gordoa.
Cancer Manag Res, 2019 Jun 14; 11. PMID: 31191015    Free PMC article.
Review.
Combination pembrolizumab plus chemotherapy: a new standard of care for patients with advanced non-small-cell lung cancer.
Frank Weinberg, Shirish Gadgeel.
Lung Cancer (Auckl), 2019 Jun 27; 10. PMID: 31239797    Free PMC article.
Immune-Related Adverse Events: A Case-Based Approach.
Caoilfhionn Connolly, Kalindi Bambhania, Jarushka Naidoo.
Front Oncol, 2019 Jul 12; 9. PMID: 31293970    Free PMC article.
Review.
Management of Adverse Events in Cancer Patients Treated With PD-1/PD-L1 Blockade: Focus on Asian Populations.
Jiqiao Yang, Xiujing He, +2 authors, Hubing Shi.
Front Pharmacol, 2019 Jul 18; 10. PMID: 31312140    Free PMC article.
Review.
PD-L1 is required for human endometrial regenerative cells-associated attenuation of experimental colitis in mice.
Ganggang Shi, Grace Wang, +6 authors, Hao Wang.
Am J Transl Res, 2019 Sep 10; 11(8). PMID: 31497192    Free PMC article.
Revisiting the PD-1 pathway.
Nikolaos Patsoukis, Qi Wang, Laura Strauss, Vassiliki A Boussiotis.
Sci Adv, 2020 Sep 20; 6(38). PMID: 32948597    Free PMC article.
Review.
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade.
Qi Peng, Xiangyan Qiu, +8 authors, Haidong Tang.
Nat Commun, 2020 Sep 26; 11(1). PMID: 32973173    Free PMC article.
Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis.
Stephanie M Slevin, Lucy C Garner, +18 authors, Satish Keshav.
J Crohns Colitis, 2020 Mar 18; 14(10). PMID: 32179884    Free PMC article.
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Carsten Tschöpe, Enrico Ammirati, +16 authors, Sophie Van Linthout.
Nat Rev Cardiol, 2020 Oct 14; 18(3). PMID: 33046850    Free PMC article.
Review.
Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.
Weilei Hu, Guosheng Wang, +2 authors, Ming You.
iScience, 2020 Oct 22; 23(10). PMID: 33083746    Free PMC article.
Review.
Pharmacogenomics for immunotherapy and immune-related cardiotoxicity.
Jessica A Castrillon, Charis Eng, Feixiong Cheng.
Hum Mol Genet, 2020 Jul 06; 29(R2). PMID: 32620943    Free PMC article.
Review.
Toxicity of Immune Checkpoint Inhibitors: Considerations for the Surgeon.
Beth A Helmink, Christina L Roland, Colleen M Kiernan, Jennifer A Wargo.
Ann Surg Oncol, 2020 Jan 23; 27(5). PMID: 31965370    Free PMC article.
Review.
Adverse cardiac events in the treatment of non-small cell lung cancer with programmed death-1and programmed death-ligand 1 inhibitors: A protocol for systematic review and meta-analysis.
Honglin Li, Deting Han, +4 authors, Lucheng Song.
Medicine (Baltimore), 2020 Aug 10; 99(32). PMID: 32769920    Free PMC article.
Cardiotoxicity of Contemporary Anticancer Immunotherapy.
Natalie Dal'bo, Rushin Patel, +4 authors, Sarju Ganatra.
Curr Treat Options Cardiovasc Med, 2020 Nov 10; 22(12). PMID: 33162729    Free PMC article.
Review.
Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance.
Priya Veluswamy, Max Wacker, Maximilian Scherner, Jens Wippermann.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142805    Free PMC article.
Review.
A different type of acute myocarditis: a case report of acute autoimmune myocarditis mediated by anti-PD-1 T lymphocyte receptor (pembrolizumab).
Mario Salido Iniesta, Laura López López, Francesc Carreras Costa, Alessandro Sionis.
Eur Heart J Case Rep, 2020 Nov 19; 4(5). PMID: 33204987    Free PMC article.
Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction.
Haiting Ma, Jacob F Jeppesen, Rudolf Jaenisch.
Cell Rep Med, 2020 Nov 19; 1(6). PMID: 33205073    Free PMC article.
Co-inhibitory Receptor Signaling in T-Cell-Mediated Autoimmune Glomerulonephritis.
Kei Nagai.
Front Med (Lausanne), 2020 Dec 01; 7. PMID: 33251233    Free PMC article.
Review.
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
Tim Magnus, Bettina Schreiner, +8 authors, Heinz Wiendl.
J Neurosci, 2005 Mar 11; 25(10). PMID: 15758163    Free PMC article.
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.
Pavan Brahmamdam, Shigeaki Inoue, +3 authors, Richard S Hotchkiss.
J Leukoc Biol, 2010 May 21; 88(2). PMID: 20483923    Free PMC article.
Highly Cited.
Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy.
Thomas Menter, Alexandar Tzankov.
Virchows Arch, 2018 Aug 23; 474(4). PMID: 30132131
The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice.
Leilei Liang, Keli Ge, Fengying Zhang, Yinlin Ge.
Cell Mol Biol Lett, 2018 Dec 20; 23. PMID: 30564277    Free PMC article.
A Case of Acute Exacerbation of Chronic Adrenal Insufficiency Due to Ipilimumab Treatment for Advanced Melanoma.
Chihiro Sakaguchi, Seiichi Yano, +11 authors, Yoshihiro Ogawa.
Am J Case Rep, 2019 Jan 27; 20. PMID: 30679413    Free PMC article.
Cardiac phenotype in mouse models of systemic autoimmunity.
Chandan Sanghera, Lok Man Wong, +3 authors, Susanne Sattler.
Dis Model Mech, 2019 Mar 13; 12(3). PMID: 30858306    Free PMC article.
Review.
Combination of CTLA-4 and PD-1 blockers for treatment of cancer.
Anand Rotte.
J Exp Clin Cancer Res, 2019 Jun 15; 38(1). PMID: 31196207    Free PMC article.
Highly Cited. Review.
The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition.
Gilda Varricchi, Stefania Loffredo, +6 authors, Maria Rosaria Galdiero.
Int J Mol Sci, 2019 Aug 16; 20(16). PMID: 31412566    Free PMC article.
Review.
PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade.
Otgontuya Ganbaatar, Satoru Konnai, +12 authors, Kazuhiko Ohashi.
PLoS One, 2020 Nov 21; 15(11). PMID: 33216754    Free PMC article.
Overcoming Immune Evasion in Melanoma.
Kevinn Eddy, Suzie Chen.
Int J Mol Sci, 2020 Dec 02; 21(23). PMID: 33256089    Free PMC article.
Review.
Regulation of PD-L1 Expression by NF-κB in Cancer.
Fabrizio Antonangeli, Ambra Natalini, +3 authors, Francesca Di Rosa.
Front Immunol, 2020 Dec 17; 11. PMID: 33324403    Free PMC article.
Review.
Regulation and Function of the PD-L1 Checkpoint.
Chong Sun, Riccardo Mezzadra, Ton N Schumacher.
Immunity, 2018 Mar 22; 48(3). PMID: 29562194    Free PMC article.
Highly Cited. Review.
The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin‑induced cardiotoxicity.
Syu-Ichi Kanno, Akiyoshi Hara.
Mol Med Rep, 2020 Dec 11; 23(2). PMID: 33300057    Free PMC article.
The Mechanism and Management of Adverse Cardiac Reactions Induced by Immune Checkpoint Inhibitors Therapy.
Fangning Rong, Kangting Ji, Yingpei Weng, Yangpei Peng.
Cardiol Res Pract, 2021 Jan 01; 2020. PMID: 33381310    Free PMC article.
Neoadjuvant checkpoint blockade for cancer immunotherapy.
Suzanne L Topalian, Janis M Taube, Drew M Pardoll.
Science, 2020 Feb 01; 367(6477). PMID: 32001626    Free PMC article.
Review.
Are activated B cells involved in the process of myocardial fibrosis after acute myocardial infarction? An in vivo experiment.
Fanrui Mo, Ying Luo, +3 authors, Weifeng Wu.
BMC Cardiovasc Disord, 2021 Jan 08; 21(1). PMID: 33407160    Free PMC article.
Cardiovascular Complications of Prostate Cancer Treatment.
Michał Wilk, Anna Waśko-Grabowska, Sebastian Szmit.
Front Pharmacol, 2021 Jan 09; 11. PMID: 33414715    Free PMC article.
Cardiovascular Toxicity of Immune Checkpoint Inhibitors: Clinical Risk Factors.
Flora Pirozzi, Remo Poto, +9 authors, Valentina Mercurio.
Curr Oncol Rep, 2021 Jan 09; 23(2). PMID: 33415405    Free PMC article.
Review.
Immunotherapy-Associated Cardiotoxicity of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T Cell Therapy: Diagnostic and Management Challenges and Strategies.
Ashley F Stein-Merlob, Michael V Rothberg, Patrick Holman, Eric H Yang.
Curr Cardiol Rep, 2021 Jan 24; 23(3). PMID: 33483873    Free PMC article.
Review.
Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome.
Akinsola Oyelakin, Erich Horeth, +17 authors, Rose-Anne Romano.
Front Immunol, 2021 Jan 26; 11. PMID: 33488608    Free PMC article.
Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice.
Siqi Li, Kazuko Tajiri, +13 authors, Masaki Ieda.
Int J Mol Sci, 2021 Feb 13; 22(3). PMID: 33572655    Free PMC article.
Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities.
Kevinn Eddy, Raj Shah, Suzie Chen.
Front Oncol, 2021 Feb 23; 10. PMID: 33614507    Free PMC article.
Review.
Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets.
Trixy Fang, Jonatan Alvelid, +3 authors, Ana I Teixeira.
ACS Nano, 2021 Feb 09; 15(2). PMID: 33556239    Free PMC article.
Cardiotoxicity Induced by Immune Checkpoint Inhibitors: A Pharmacovigilance Study From 2014 to 2019 Based on FAERS.
Chenxin Chen, Ting Chen, +9 authors, Jia He.
Front Pharmacol, 2021 Mar 02; 12. PMID: 33643048    Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
Review.
Immune Profile Analysis in Peripheral Blood and Tumor in Patients with Malignant Melanoma.
Ryuichi Saito, Yu Sawada, Motonobu Nakamura.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33669410    Free PMC article.
Building Multi-Dimensional Induced Pluripotent Stem Cells-Based Model Platforms to Assess Cardiotoxicity in Cancer Therapies.
Dilip Thomas, Sushma Shenoy, Nazish Sayed.
Front Pharmacol, 2021 Mar 09; 12. PMID: 33679396    Free PMC article.
Review.
Low-Dose Decitabine Inhibits Cytotoxic T Lymphocytes-Mediated Platelet Destruction via Modulating PD-1 Methylation in Immune Thrombocytopenia.
Panpan Han, Tianshu Yu, +13 authors, Ming Hou.
Front Immunol, 2021 Mar 09; 12. PMID: 33679776    Free PMC article.
Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy.
Rangarirai Makuku, Neda Khalili, +2 authors, Nima Rezaei.
J Immunol Res, 2021 Mar 09; 2021. PMID: 33681388    Free PMC article.
Review.
Autoimmune complications of cancer immunotherapy.
Kavita M Dhodapkar.
Curr Opin Immunol, 2019 Sep 27; 61. PMID: 31557690    Free PMC article.
Review.
Novel PD-L1 mAb HC16 reveals upregulation of PD-L1 in BAC subtype.
Bor-Chyuan Su, Chen-Hung Ting, +4 authors, Jyh-Yih Chen.
Histol Histopathol, 2020 Oct 29; 36(1). PMID: 33112410
An in vivo method for diversifying the functions of therapeutic antibodies.
Ming Tian, Hwei-Ling Cheng, +8 authors, Frederick W Alt.
Proc Natl Acad Sci U S A, 2021 Mar 05; 118(10). PMID: 33658386    Free PMC article.
Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia.
Joerg Herrmann.
Nat Rev Cardiol, 2020 Apr 02; 17(8). PMID: 32231332    Free PMC article.
Review.
The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy.
Jongdae Lee, Beatriz Lozano-Ruiz, +3 authors, Jose M González-Navajas.
Front Immunol, 2021 Mar 30; 12. PMID: 33777008    Free PMC article.
Review.
Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer.
Pilar Martín, Rafael Blanco-Domínguez, Raquel Sánchez-Díaz.
Cell Mol Immunol, 2020 Nov 26; 18(4). PMID: 33235388    Free PMC article.
Review.
Advanced Nanotechnology for Enhancing Immune Checkpoint Blockade Therapy.
Chiara Cremolini, Emanuela Vitale, Raffaella Rastaldo, Claudia Giachino.
Nanomaterials (Basel), 2021 Apr 04; 11(3). PMID: 33800368    Free PMC article.
Review.
Thyroid Dysfunction in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors (ICIs): Outcomes in a Multiethnic Urban Cohort.
Angelica D'Aiello, Juan Lin, +5 authors, Balazs Halmos.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33806774    Free PMC article.
PD-1/PDL-1 Inhibitors and Cardiotoxicity; Molecular, Etiological and Management Outlines.
Mohammed Safi, Hyat Ahmed, +6 authors, Jiwei Liu.
J Adv Res, 2021 Apr 13; 29. PMID: 33842004    Free PMC article.
Review.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison.
Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470    Free PMC article.
A snapshot of the PD-1/PD-L1 pathway.
Chinmoy Ghosh, Gary Luong, Yue Sun.
J Cancer, 2021 Apr 16; 12(9). PMID: 33854633    Free PMC article.
Review.
Emerging Role of PD-1 in the Central Nervous System and Brain Diseases.
Junli Zhao, Alexus Roberts, +2 authors, Ru-Rong Ji.
Neurosci Bull, 2021 Apr 21; 37(8). PMID: 33877518    Free PMC article.
Review.
Function and Role of Regulatory T Cells in Rheumatoid Arthritis.
Qi Jiang, Guocan Yang, +2 authors, Dawei Cui.
Front Immunol, 2021 Apr 20; 12. PMID: 33868244    Free PMC article.
Review.
Is There a Place for PD-1-PD-L Blockade in Acute Myeloid Leukemia?
Laura Jimbu, Oana Mesaros, +5 authors, Mihnea Zdrenghea.
Pharmaceuticals (Basel), 2021 Apr 04; 14(4). PMID: 33804850    Free PMC article.
Review.
Immunotherapy for Prostate Cancer.
Nicholas J Venturini, Charles G Drake.
Cold Spring Harb Perspect Med, 2018 Sep 12; 9(5). PMID: 30201787    Free PMC article.
Review.
Checkpoint Inhibitor-Induced Colitis-A Clinical Overview of Incidence, Prognostic Implications and Extension of Current Treatment Options.
Carmen Portenkirchner, Peter Kienle, Karoline Horisberger.
Pharmaceuticals (Basel), 2021 May 01; 14(4). PMID: 33923423    Free PMC article.
Review.
The Role of Programmed Death-1 in Type 1 Diabetes.
Christopher G Tucker, Alexander J Dwyer, Brian T Fife, Tijana Martinov.
Curr Diab Rep, 2021 May 07; 21(6). PMID: 33956235    Free PMC article.
Review.
Cardiotoxicity of Immune Checkpoint Inhibitors.
Rushin P Patel, Rohan Parikh, +4 authors, Anju Nohria.
Curr Oncol Rep, 2021 May 04; 23(7). PMID: 33937956    Free PMC article.
Review.
Mechanisms and Management of Immune Checkpoint Inhibitor-Related Cardiac Adverse Events.
Hiroshi Kadowaki, Hiroshi Akazawa, Junichi Ishida, Issei Komuro.
JMA J, 2021 May 18; 4(2). PMID: 33997442    Free PMC article.
Review.
Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity.
Meihua Qiu, Yuqing Chen, Qiao Ye.
BMC Pulm Med, 2021 May 24; 21(1). PMID: 34022844    Free PMC article.
Modulating T Follicular Cells In Vivo Enhances Antigen-Specific Humoral Immunity.
Jose D Pagan, Hera Vlamakis, +2 authors, Robert M Anthony.
J Immunol, 2021 May 21; 206(11). PMID: 34011521    Free PMC article.
Immune Cells and Immunotherapy for Cardiac Injury and Repair.
Joel G Rurik, Haig Aghajanian, Jonathan A Epstein.
Circ Res, 2021 May 28; 128(11). PMID: 34043424    Free PMC article.
Review.
Comparative Transcriptomics of Immune Checkpoint Inhibitor Myocarditis Identifies Guanylate Binding Protein 5 and 6 Dysregulation.
Daniel Finke, Markus B Heckmann, +11 authors, Lorenz H Lehmann.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34065419    Free PMC article.
Molecular Mechanisms of PD-1 and PD-L1 Activity on a Pan-Cancer Basis: A Bioinformatic Exploratory Study.
Siddarth Kannan, Geraldine Martina O'Connor, Emyr Yosef Bakker.
Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34067485    Free PMC article.
Risk of Cardiac Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-Analysis.
Jiexuan Hu, Ruyue Tian, +4 authors, Bangwei Cao.
Front Oncol, 2021 Jun 15; 11. PMID: 34123795    Free PMC article.
Systematic Review.
Generation of triacyl lipopeptide-modified glycoproteins by metabolic glycoengineering as the neoantigen to boost anti-tumor immune response.
Yujia Zhao, Siyu Li, +10 authors, Rong Xiang.
Theranostics, 2021 Jun 24; 11(15). PMID: 34158858    Free PMC article.
Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners.
Marek Z Wojtukiewicz, Magdalena M Rek, +7 authors, Kenneth V Honn.
Cancer Metastasis Rev, 2021 Jul 09; 40(3). PMID: 34236546    Free PMC article.
Review.
Immunoadsorption treatment for dilated cardiomyopathy: A PRISMA-compliant systematic review and meta-analysis.
Ru-Tao Bian, Zhen-Tao Wang, Wei-Yu Li.
Medicine (Baltimore), 2021 Jul 01; 100(26). PMID: 34190171    Free PMC article.
Systematic Review.
A phase I study of IMC-001, a PD-L1 blocker, in patients with metastatic or locally advanced solid tumors.
Bhumsuk Keam, Chan-Young Ock, +12 authors, Young Suk Park.
Invest New Drugs, 2021 Jul 17; 39(6). PMID: 34268711
Cardiac Toxicities Associated with Immune Checkpoints Inhibitors: Mechanisms, Manifestations and Management.
Abdulrazzak Zarifa, Jin Wan Kim, +3 authors, Peter Y Kim.
Korean Circ J, 2021 Jul 07; 51(7). PMID: 34227272    Free PMC article.
Review.
Myocarditis Induced by Immune Checkpoint Inhibitors: Mechanisms and Therapeutic Prospects.
Wenlu Zou, Jie Lu, Yan Hao.
J Inflamm Res, 2021 Jul 17; 14. PMID: 34267536    Free PMC article.
Review.
Serum Troponin T Concentrations Are Frequently Elevated in Advanced Skin Cancer Patients Prior to Immune Checkpoint Inhibitor Therapy: Experience From a Single Tertiary Referral Center.
Jonas K Kurzhals, Tobias Graf, +5 authors, Ewan A Langan.
Front Med (Lausanne), 2021 Jul 23; 8. PMID: 34291066    Free PMC article.
Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review.
Shujing Liang, Jingxian Yang, +4 authors, Chunyan Dong.
Front Immunol, 2021 Jul 27; 12. PMID: 34305915    Free PMC article.
Review.
Computational design of a synthetic PD-1 agonist.
Cassie M Bryan, Gabriel J Rocklin, +10 authors, David Baker.
Proc Natl Acad Sci U S A, 2021 Jul 18; 118(29). PMID: 34272285    Free PMC article.
Myocardial and Pericardial Toxicity Associated With Immune Checkpoint Inhibitors in Cancer Patients.
Johnny Chahine, Patrick Collier, +2 authors, Allan L Klein.
JACC Case Rep, 2020 Feb 19; 2(2). PMID: 34317203    Free PMC article.
Immunotherapy-Related Cystitis: Case Report and Review of the Literature.
Liping Zhu, Zhiqiang Wang, +2 authors, Ling Peng.
Onco Targets Ther, 2021 Aug 10; 14. PMID: 34366676    Free PMC article.
Immune Checkpoint Inhibitors and Cardiotoxicity: An Analysis of Spontaneous Reports in Eudravigilance.
Annamaria Mascolo, Cristina Scavone, +8 authors, Annalisa Capuano.
Drug Saf, 2021 Jun 20; 44(9). PMID: 34145536    Free PMC article.
Immune Checkpoint Inhibitors in Special Populations.
Qianyun Shan, Hongyang Lu.
Technol Cancer Res Treat, 2021 Aug 14; 20. PMID: 34384286    Free PMC article.
Review.
Immune Checkpoint Inhibitors Mediated Lymphocytic and Giant Cell Myocarditis: Uncovering Etiological Mechanisms.
Rishi Rikhi, Jaret Karnuta, +5 authors, Rohit Moudgil.
Front Cardiovasc Med, 2021 Aug 27; 8. PMID: 34434981    Free PMC article.
Review.
Preclinical Models of Cancer Therapy-Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association.
Aarti Asnani, Javid J Moslehi, +8 authors, American Heart Association Council on Basic Cardiovascular Sciences; Cardio-Oncology Science Subcommittee of Council on Genomic and Precision Medicine and Council on Clinical Cardiology; Council on Peripheral Vascular Disease; and Council on Arteriosclerosis, Thrombosis and Vascular Biology.
Circ Res, 2021 May 04; 129(1). PMID: 33934611    Free PMC article.
Review.
The Role of Oncogenes and Redox Signaling in the Regulation of PD-L1 in Cancer.
Christophe Glorieux, Xiaojun Xia, Peng Huang.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503236    Free PMC article.
Review.
Clinical and molecular parameters associated to pneumonitis development in non-small-cell lung cancer patients receiving chemoimmunotherapy from NADIM trial.
Belén Sierra-Rodero, Alberto Cruz-Bermúdez, +23 authors, Mariano Provencio.
J Immunother Cancer, 2021 Aug 28; 9(8). PMID: 34446577    Free PMC article.
Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer.
Yong-Bo Kang, Yue Cai.
World J Gastroenterol, 2021 Sep 21; 27(32). PMID: 34539138    Free PMC article.
Review.
Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity.
Takeshi Susukida, Saki Kuwahara, +3 authors, Kousei Ito.
Commun Biol, 2021 Sep 30; 4(1). PMID: 34584206    Free PMC article.
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH.
Sunil Kumar, Parth Sarthi, +4 authors, Yong-Soo Bae.
Cells, 2021 Sep 29; 10(9). PMID: 34571899    Free PMC article.
Review.
Glucocorticoid and PD-1 Cross-Talk: Does the Immune System Become Confused?
Sabrina Adorisio, Lorenza Cannarile, Domenico V Delfino, Emira Ayroldi.
Cells, 2021 Sep 29; 10(9). PMID: 34571982    Free PMC article.
Review.
Mechanisms and Insights for the Development of Heart Failure Associated with Cancer Therapy.
Claire Fraley, Sarah A Milgrom, +3 authors, Shelley D Miyamoto.
Children (Basel), 2021 Sep 29; 8(9). PMID: 34572260    Free PMC article.
Review.
Targeting TIGIT for Immunotherapy of Cancer: Update on Clinical Development.
Anand Rotte, Srikumar Sahasranaman, Nageshwar Budha.
Biomedicines, 2021 Sep 29; 9(9). PMID: 34572463    Free PMC article.
Review.
Targeting the spectrum of immune checkpoints in prostate cancer.
Laura A Sena, Samuel R Denmeade, Emmanuel S Antonarakis.
Expert Rev Clin Pharmacol, 2021 Jul 16; 14(10). PMID: 34263692    Free PMC article.
Review.
Immune Checkpoint Inhibitors and the Heart.
Diana Larisa Mocan-Hognogi, Sebastian Trancǎ, +3 authors, Anca Simona Bojan.
Front Cardiovasc Med, 2021 Oct 19; 8. PMID: 34660728    Free PMC article.
Review.
[Research Progress of Immune Checkpoint Inhibitor-associated Myocarditis].
Yunwei Liu, Yanxin Chen, Zhimin Zeng, Anwen Liu.
Zhongguo Fei Ai Za Zhi, 2021 Sep 16; 24(9). PMID: 34521189    Free PMC article.
PD-1 preferentially inhibits the activation of low-affinity T cells.
Kenji Shimizu, Daisuke Sugiura, +3 authors, Taku Okazaki.
Proc Natl Acad Sci U S A, 2021 Aug 27; 118(35). PMID: 34433672    Free PMC article.
Cardiotoxicity of Cancer Treatments: Focus on Anthracycline Cardiomyopathy.
Masahiro Nishi, Ping-Yuan Wang, Paul M Hwang.
Arterioscler Thromb Vasc Biol, 2021 Oct 01; 41(11). PMID: 34587760    Free PMC article.
Review.
The Upregulation of Molecules Related to Tumor Immune Escape in Human Pituitary Adenomas.
Zhiyu Xi, Pamela S Jones, +8 authors, Xun Zhang.
Front Endocrinol (Lausanne), 2021 Nov 09; 12. PMID: 34745002    Free PMC article.
Checkpoint Inhibitors in Melanoma Patients with Underlying Autoimmune Disease.
Hilary Dietz, Sophia C Weinmann, April K Salama.
Cancer Manag Res, 2021 Nov 11; 13. PMID: 34754240    Free PMC article.
Review.
Biological Bases of Immune-Related Adverse Events and Potential Crosslinks With Immunogenic Effects of Radiation.
Lilia Bardoscia, Nadia Pasinetti, +2 authors, Angela Sardaro.
Front Pharmacol, 2021 Nov 19; 12. PMID: 34790123    Free PMC article.
Review.
Unravelling Checkpoint Inhibitor Associated Autoimmune Diabetes: From Bench to Bedside.
Linda Wu, Venessa H M Tsang, +5 authors, Jenny E Gunton.
Front Endocrinol (Lausanne), 2021 Nov 23; 12. PMID: 34803927    Free PMC article.
Review.
Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.
Clemens Hinterleitner, Jasmin Strähle, +20 authors, Lars Zender.
Nat Commun, 2021 Dec 03; 12(1). PMID: 34853305    Free PMC article.
Role of the PD-1/PD-L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions.
Yan Mi, Jinming Han, Jie Zhu, Tao Jin.
Mol Neurobiol, 2021 Sep 05; 58(12). PMID: 34480337    Free PMC article.
Review.
Role of PD-L1 in licensing immunoregulatory function of dental pulp mesenchymal stem cells.
Rosanna Di Tinco, Giulia Bertani, +11 authors, Gianluca Carnevale.
Stem Cell Res Ther, 2021 Dec 06; 12(1). PMID: 34863286    Free PMC article.
Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy.
Nicolas Jacquelot, Maryam Ghaedi, +3 authors, Pamela S Ohashi.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885076    Free PMC article.
Review.
Immunotherapy of Ovarian Cancer with Particular Emphasis on the PD-1/PDL-1 as Target Points.
Janina Świderska, Mateusz Kozłowski, Sebastian Kwiatkowski, Aneta Cymbaluk-Płoska.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885169    Free PMC article.
Review.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial.
Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg.
Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915
Review.
Case Report: Cardiac Toxicity Associated With Immune Checkpoint Inhibitors.
Ru Chen, Ling Peng, +4 authors, Feng Zhu.
Front Cardiovasc Med, 2021 Dec 24; 8. PMID: 34938778    Free PMC article.
Cardiotoxicity and Chemotherapy-The Role of Precision Medicine.
Thyla Viswanathan, Chim C Lang, Russell D Petty, Mark A Baxter.
Diseases, 2021 Dec 24; 9(4). PMID: 34940028    Free PMC article.
Review.
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy.
Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern.
Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146    Free PMC article.
Review.
Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.
Markus P Kummer, Christina Ising, +11 authors, Michael T Heneka.
EMBO J, 2021 Nov 27; 40(24). PMID: 34825707    Free PMC article.
Bradyarrhythmias in Cardio-Oncology.
Marta Fonseca, Evaline Cheng, +5 authors, Avirup Guha.
South Asian J Cancer, 2021 Dec 31; 10(3). PMID: 34966697    Free PMC article.
pH Low Insertion Peptide-Modified Programmed Cell Death-Ligand 1 Potently Suppresses T-Cell Activation Under Acidic Condition.
Ying Sun, Linhan Hu, +11 authors, Guojiang Chen.
Front Immunol, 2022 Jan 11; 12. PMID: 35003115    Free PMC article.
Metabolic Implications of Immune Checkpoint Proteins in Cancer.
Elizabeth R Stirling, Steven M Bronson, +3 authors, David R Soto-Pantoja.
Cells, 2022 Jan 12; 11(1). PMID: 35011741    Free PMC article.
Review.
Strategies to overcome drug resistance using SHP2 inhibitors.
Meng Liu, Shan Gao, +2 authors, Hao Fang.
Acta Pharm Sin B, 2022 Jan 14; 11(12). PMID: 35024315    Free PMC article.
Review.
Immune-checkpoint inhibitors: long-term implications of toxicity.
Douglas B Johnson, Caroline A Nebhan, Javid J Moslehi, Justin M Balko.
Nat Rev Clin Oncol, 2022 Jan 28; 19(4). PMID: 35082367    Free PMC article.
Review.
Vitamin D can reduce severity in COVID-19 through regulation of PD-L1.
Hatice Aygun.
Naunyn Schmiedebergs Arch Pharmacol, 2022 Feb 01; 395(4). PMID: 35099571    Free PMC article.
Review.
A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy.
Jin Bian, Yan Niu, +2 authors, Ning Ma.
Appl Bionics Biomech, 2022 Feb 08; 2022. PMID: 35126664    Free PMC article.
Sudden and severe cardiotoxicity induced with pembrolizumab, its clinical course, therapeutic intervention, and outcome.
Tomohiro Matsumoto, Koji Fukuda, +9 authors, Hiroyuki Shibata.
Int Cancer Conf J, 2022 Feb 08; 11(1). PMID: 35127324    Free PMC article.
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity.
Daisuke Sugiura, Il-Mi Okazaki, +6 authors, Taku Okazaki.
Nat Immunol, 2022 Feb 12; 23(3). PMID: 35145298
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1.
Yuwei Hao, Matthew C Cook.
Front Immunol, 2022 Feb 15; 12. PMID: 35154081    Free PMC article.
Review.
Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors.
Sherry-Ann Brown, Jordan C Ray, Joerg Herrmann.
J Cardiovasc Transl Res, 2020 Apr 08; 13(3). PMID: 32253744    Free PMC article.
Review.
The Potential Cardiotoxicity of Immune Checkpoint Inhibitors.
Inbar Nardi Agmon, Osnat Itzhaki Ben Zadok, Ran Kornowski.
J Clin Med, 2022 Feb 16; 11(3). PMID: 35160316    Free PMC article.
Review.
Overexpression of Programmed Cell Death 1 Prevents Doxorubicin-Induced Apoptosis Through Autophagy Induction in H9c2 Cardiomyocytes.
Syu-Ichi Kanno, Akiyoshi Hara.
Cardiovasc Toxicol, 2022 Feb 23; 22(5). PMID: 35190965    Free PMC article.
The Diagnosis and Management of Immune Checkpoint Inhibitor Cardiovascular Toxicity: Myocarditis and Beyond.
Dan Gilon, Zaza Iakobishvili, David Leibowitz.
Vaccines (Basel), 2022 Feb 27; 10(2). PMID: 35214762    Free PMC article.
Review.
Cardiotoxicity risk factors with immune checkpoint inhibitors.
Zachary L Brumberger, Mary E Branch, +3 authors, Sujethra Vasu.
Cardiooncology, 2022 Mar 13; 8(1). PMID: 35277208    Free PMC article.
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors.
Alan H Baik, Katy K Tsai, David Y Oh, Mandar A Aras.
Clin Sci (Lond), 2021 Mar 10; 135(5). PMID: 33686402    Free PMC article.
Review.
CMTM6 as a master regulator of PD-L1.
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani.
Cancer Immunol Immunother, 2022 Mar 17;. PMID: 35294592
Review.
Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors.
Xin Du, Phillip K Darcy, Florian Wiede, Tony Tiganis.
Mol Cell Biol, 2022 Jan 19; 42(3). PMID: 35041491    Free PMC article.
Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy.
Jii Bum Lee, Hye Ryun Kim, Sang-Jun Ha.
Immune Netw, 2022 Mar 17; 22(1). PMID: 35291660    Free PMC article.
Review.
Checkpoint Inhibitors and Induction of Celiac Disease-like Condition.
Aaron Lerner, Carina Benzvi.
Biomedicines, 2022 Mar 26; 10(3). PMID: 35327411    Free PMC article.
Review.
Effects of PD-1 Signaling on Immunometabolic Reprogramming.
Vassiliki A Boussiotis, Nikolaos Patsoukis.
Immunometabolism, 2022 Apr 05; 4(2). PMID: 35371563    Free PMC article.
Immune Checkpoint Therapies and Atherosclerosis: Mechanisms and Clinical Implications: JACC State-of-the-Art Review.
Jacqueline T Vuong, Ashley F Stein-Merlob, +3 authors, Eric H Yang.
J Am Coll Cardiol, 2022 Feb 12; 79(6). PMID: 35144750    Free PMC article.
Review.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
Review.
A Systematic Review of the Mechanisms Involved in Immune Checkpoint Inhibitors Cardiotoxicity and Challenges to Improve Clinical Safety.
Nestor Rubio-Infante, Yoel Adbel Ramírez-Flores, +3 authors, Guillermo Torre-Amione.
Front Cell Dev Biol, 2022 Apr 19; 10. PMID: 35433707    Free PMC article.
Combining Radiotherapy and Immunotherapy in Metastatic Breast Cancer: Current Status and Future Directions.
Steven David, Jennifer Tan, +3 authors, Sherene Loi.
Biomedicines, 2022 Apr 24; 10(4). PMID: 35453571    Free PMC article.
Review.
Exploring the Mechanisms Underlying the Cardiotoxic Effects of Immune Checkpoint Inhibitor Therapies.
Daniel Ronen, Aseel Bsoul, +4 authors, Rabea Asleh.
Vaccines (Basel), 2022 Apr 24; 10(4). PMID: 35455289    Free PMC article.
Review.
Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events.
Remo Poto, Teresa Troiani, +4 authors, Gilda Varricchi.
Front Immunol, 2022 Apr 19; 13. PMID: 35432346    Free PMC article.
Review.
Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues.
Christopher M Bailey, Yan Liu, +5 authors, Yin Wang.
J Clin Invest, 2022 Mar 04; 132(9). PMID: 35239514    Free PMC article.
Melanoma: An immunotherapy journey from bench to bedside.
Vishal Navani, Moira C Graves, +4 authors, Nikola A Bowden.
Cancer Treat Res, 2022 May 14; 183. PMID: 35551656
Genetics of cancer therapy-associated cardiotoxicity.
Yuri Kim, Jonathan G Seidman, Christine E Seidman.
J Mol Cell Cardiol, 2022 Apr 01; 167. PMID: 35358500    Free PMC article.
Review.