Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

D T Denhardt ¹, M Noda , A W O'Regan , D Pavlin , J S Berman

Affiliations

¹ Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA. denhardt@biology.rutgers.edu

PMID: 11342566
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320 citations

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Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. Daniel J Schneider, Janci C Lindsay, +2 authors, Yang Zhou, Jose G Molina, Michael R Blackburn. less FASEB J, 2009 Sep 02; 24(1). PMID: 19720619 Free PMC article.
Osteopontin is not crucial to protective immunity during murine tuberculosis. Gerritje J W van der Windt, Catharina W Wieland, +2 authors, Tom van der Poll. less Immunology, 2009 Sep 25; 128(1 Suppl). PMID: 19740338 Free PMC article.
Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis. Karin Alain, Niel A Karrow, +3 authors, Nathalie Bissonnette. less BMC Genomics, 2009 Sep 22; 10. PMID: 19765294 Free PMC article.
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. Shadi A Sharif, Xiaoyan Du, +8 authors, Lawrence L K Leung. less Arthritis Rheum, 2009 Oct 01; 60(10). PMID: 19790060 Free PMC article.
Mechanisms of intermittent hypoxia induced hypertension. Laura V González Bosc, Thomas Resta, Benjimen Walker, Nancy L Kanagy. J Cell Mol Med, 2009 Oct 13; 14(1-2). PMID: 19818095 Free PMC article. Review.
Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGH. Jin-Cai Wu, Bing-Sheng Sun, +2 authors, Ning Ren, Qing-Hai Ye, Lun-Xiu Qin. less J Cancer Res Clin Oncol, 2009 Oct 17; 136(4). PMID: 19834740
Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats. Hidenori Suzuki, Robert Ayer, +5 authors, John H Zhang. less Crit Care Med, 2009 Oct 24; 38(2). PMID: 19851092 Free PMC article.
Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. Gul Zaman, Leanne K Saxon, +5 authors, Lance E Lanyon. less Bone, 2009 Oct 28; 46(3). PMID: 19857613 Free PMC article.
Antigen-specific induction of osteopontin contributes to the chronification of allergic contact dermatitis. Anne M Seier, Andreas C Renkl, +7 authors, Johannes M Weiss. less Am J Pathol, 2009 Dec 17; 176(1). PMID: 20008129 Free PMC article.
Implication of expression of osteopontin and its receptor integrin alphanubeta3 in the placenta in the development of preeclampsia. Junxia Xia, Fuyuan Qiao, Fangmin Su, Haiyi Liu. J Huazhong Univ Sci Technolog Med Sci, 2009 Dec 29; 29(6). PMID: 20037822
Mechanisms of immune-mediated liver injury. David H Adams, Cynthia Ju, +2 authors, Shashi K Ramaiah, Jack Uetrecht, Hartmut Jaeschke. less Toxicol Sci, 2010 Jan 15; 115(2). PMID: 20071422 Free PMC article. Review.
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. Donald Courter, Hongbin Cao, +10 authors, Quynh-Thu Le. less PLoS One, 2010 Mar 13; 5(3). PMID: 20224789 Free PMC article.
Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage. Eva Kiss, Zoran V Popovic, +12 authors, Hermann-Josef Gröne. less Am J Pathol, 2010 Apr 07; 176(5). PMID: 20363918 Free PMC article.
Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists. Wei Zhao, Lijuan Wang, +3 authors, Lei Zhang, Chao Yuan, Paul C Kuo, Chengjiang Gao. less J Biol Chem, 2010 Apr 30; 285(27). PMID: 20427276 Free PMC article.
Recombinant osteopontin attenuates brain injury after intracerebral hemorrhage in mice. Bihua Wu, Qingyi Ma, +4 authors, John Zhang. less Neurocrit Care, 2010 May 05; 14(1). PMID: 20440599
Apc(MIN) modulation of vitamin D secosteroid growth control. Haibo Xu, Gary H Posner, Michael Stevenson, Frederick C Campbell. Carcinogenesis, 2010 May 22; 31(8). PMID: 20488884 Free PMC article.
The differences between the localizations of MUC1, MUC5AC, MUC6 and osteopontin in quail proventriculus and gizzard may be a reflection of functional differences of stomach parts. Narin Liman, Emel Alan, Güner Küçük Bayram. J Anat, 2010 May 25; 217(1). PMID: 20492430 Free PMC article.
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. Wei Yan, Chunfa Qian, +8 authors, Yongping You. less Neuro Oncol, 2010 Jun 01; 12(8). PMID: 20511184 Free PMC article.
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Gopal Murugaiyan, Akanksha Mittal, Howard L Weiner. Proc Natl Acad Sci U S A, 2010 Jun 11; 107(25). PMID: 20534530 Free PMC article.
Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin. Melissa Lazar, Jennifer Sullivan, +7 authors, Hwyda A Arafat. less Surgery, 2010 Jun 29; 148(2). PMID: 20579680 Free PMC article.
Role of tissue inhibitor of metalloproteinases-1 in the development of autoimmune lymphoproliferation. Elena Boggio, Manuela Indelicato, +6 authors, Annalisa Chiocchetti. less Haematologica, 2010 Jul 03; 95(11). PMID: 20595097 Free PMC article.
Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells. Priyanka Sharma, Santosh Kumar, Gopal C Kundu. Mol Cancer, 2010 Jul 09; 9. PMID: 20609221 Free PMC article.
Cleavage of osteopontin by matrix metalloproteinase-12 modulates experimental autoimmune encephalomyelitis disease in C57BL/6 mice. Angelika Goncalves DaSilva, Lucy Liaw, V Wee Yong. Am J Pathol, 2010 Jul 24; 177(3). PMID: 20651245 Free PMC article.
Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C. Sai-ichi Tanaka, Takayoshi Sumioka, +6 authors, Shizuya Saika. less Mol Vis, 2010 Jul 29; 16. PMID: 20664686 Free PMC article.
Osteopontin overproduction is associated with progression of glomerular fibrosis in a rat model of anti-glomerular basement membrane glomerulonephritis. Justin Merszei, Jean Wu, +4 authors, Ya-Huan Lou. less Am J Nephrol, 2010 Aug 18; 32(3). PMID: 20714131 Free PMC article.
Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis. Cindy Zhou, Jean Wu, +4 authors, Ya-Huan Lou. less Am J Nephrol, 2010 Aug 20; 32(4). PMID: 20720406 Free PMC article.
Osteopontin regulates anabolic effect in human menopausal osteoporosis with intermittent parathyroid hormone treatment. T-I Chiang, I-C Chang, +3 authors, H-S Lee, H Lee, C-H Huang, Y-W Cheng. less Osteoporos Int, 2010 Aug 25; 22(2). PMID: 20734029
Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis). Gerritje J W van der Windt, W Joost Wiersinga, +5 authors, Tom van der Poll. less PLoS Negl Trop Dis, 2010 Sep 09; 4(8). PMID: 20824216 Free PMC article.
Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells. Melissa Lazar, Jennifer Sullivan, +8 authors, Hwyda A Arafat. less J Gastrointest Surg, 2010 Sep 09; 14(10). PMID: 20824368
Differential gene expression in well-healed and poorly healed experimental aneurysms after coil treatment. Ramanathan Kadirvel, Yong-Hong Ding, +2 authors, Daying Dai, Debra A Lewis, David F Kallmes. less Radiology, 2010 Sep 11; 257(2). PMID: 20829543 Free PMC article.
The impact of the extracellular matrix on inflammation. Lydia Sorokin. Nat Rev Immunol, 2010 Sep 25; 10(10). PMID: 20865019 Highly Cited. Review.
Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages. Hongtao Guo, Zhiyong Mi, +2 authors, Dawn E Bowles, Syamal D Bhattacharya, Paul C Kuo. less J Biol Chem, 2010 Oct 05; 285(48). PMID: 20889505 Free PMC article.
1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model. Hyo-Jung Lee, Soo-Jin Jeong, +4 authors, Sung-Hoon Kim. less Kidney Int, 2010 Nov 19; 79(5). PMID: 21085110 Free PMC article.
Genes and abdominal aortic aneurysm. Irene Hinterseher, Gerard Tromp, Helena Kuivaniemi. Ann Vasc Surg, 2010 Dec 15; 25(3). PMID: 21146954 Free PMC article. Review.
Molecular mechanisms underlying hypothermia-induced neuroprotection. Yasushi Shintani, Yasuko Terao, Hiroyuki Ohta. Stroke Res Treat, 2010 Dec 15; 2011. PMID: 21151700 Free PMC article.
Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice. Kyeong-Nam Yu, Arash Minai-Tehrani, +15 authors, Myung-Haing Cho. less PLoS One, 2011 Jan 05; 5(12). PMID: 21203518 Free PMC article.
NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages. Wei Zhao, Lijuan Wang, +7 authors, Chengjiang Gao. less J Immunol, 2011 Jan 25; 186(5). PMID: 21257959 Free PMC article.
Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Wanqiu Chen, Qingyi Ma, +3 authors, John H Zhang. less Stroke, 2011 Jan 29; 42(3). PMID: 21273567 Free PMC article.
Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen. Sunanda S Baliga, Gary F Merrill, Mari L Shinohara, David T Denhardt. PLoS One, 2011 Feb 02; 6(1). PMID: 21283687 Free PMC article.
Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. Norihisa Nishimichi, Hiromi Hayashita-Kinoh, +3 authors, Yasuyuki Yokosaki. less J Biol Chem, 2011 Feb 16; 286(13). PMID: 21321126 Free PMC article.
Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes. Ahmed M Abu El-Asrar, Luc Missotten, Karel Geboes. Mol Vis, 2011 Mar 03; 17. PMID: 21365018 Free PMC article.
Perinatal exposure to low-dose DE-71 increases serum thyroid hormones and gonadal osteopontin gene expression. Charles A Blake, George L McCoy, Yvonne Y Hui, Holly A LaVoie. Exp Biol Med (Maywood), 2011 Mar 04; 236(4). PMID: 21367881 Free PMC article.
Hematopoietic derived cell infiltration of the intestinal tumor microenvironment in Apc Min/+ mice. Celestia Davis, Robert Price, +4 authors, Maria Marjorette O Peña. less Microsc Microanal, 2011 Apr 09; 17(4). PMID: 21473808 Free PMC article.
Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology. Maki Morishita, Noriaki Ono, +12 authors, Masaki Noda. less Tissue Cell, 2011 Apr 23; 43(3). PMID: 21511320 Free PMC article.
Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls. Paolo Poggio, Juan B Grau, +4 authors, Giovanni Ferrari. less J Cell Physiol, 2011 Apr 27; 226(8). PMID: 21520066 Free PMC article.
Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway. Xianmin Luo, Megan K Ruhland, +2 authors, Ermira Pazolli, Anne C Lind, Sheila A Stewart. less Mol Cancer Res, 2011 Jun 16; 9(8). PMID: 21673011 Free PMC article.
Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. Uttio Roy Chowdhury, Seung-Youn Jea, +2 authors, Dong-Jin Oh, Douglas J Rhee, Michael P Fautsch. less Invest Ophthalmol Vis Sci, 2011 Jul 12; 52(9). PMID: 21743018 Free PMC article.
Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis: the crosstalk between bone and adipose tissue. Majid Assadi, Hooman Salimipour, +7 authors, Iraj Nabipour. less PLoS One, 2011 Sep 22; 6(9). PMID: 21935388 Free PMC article.
Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice. Petrus Jansen van Vuren, Caroline T Tiemessen, Janusz T Paweska. PLoS One, 2011 Sep 29; 6(9). PMID: 21949840 Free PMC article.
Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling. Raquel Urtasun, Aritz Lopategi, +6 authors, Natalia Nieto. less Hepatology, 2011 Sep 29; 55(2). PMID: 21953216 Free PMC article.
The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity. Cedric Hunter, Jennifer Bond, +2 authors, Paul C Kuo, Maria Angelica Selim, Howard Levinson. less J Surg Res, 2011 Oct 04; 176(1). PMID: 21962803 Free PMC article.
Sympathetic control of bone mass regulated by osteopontin. Masashi Nagao, Timothy N Feinstein, +16 authors, Masaki Noda. less Proc Natl Acad Sci U S A, 2011 Oct 13; 108(43). PMID: 21990347 Free PMC article.
Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells. Kate S Arbon, Cody M Christensen, Wendy A Harvey, Sara J Heggland. Food Chem Toxicol, 2011 Oct 25; 50(2). PMID: 22019892 Free PMC article.
Overlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functions. Loredana Frasca, Roberto Lande. ScientificWorldJournal, 2011 Nov 30; 11. PMID: 22125457 Free PMC article. Review.
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Ming Shan, Xiaoyi Yuan, +9 authors, Farrah Kheradmand. less Sci Transl Med, 2012 Jan 21; 4(117). PMID: 22261033 Free PMC article.
NF-κB and matrix-dependent regulation of osteopontin promoter activity in allylamine-activated vascular smooth muscle cells. E Spencer Williams, Emily Wilson, Kenneth S Ramos. Oxid Med Cell Longev, 2012 Feb 09; 2012. PMID: 22315656 Free PMC article.
Peripheral blood biomarkers in idiopathic pulmonary fibrosis. Rekha Vij, Imre Noth. Transl Res, 2012 Mar 20; 159(4). PMID: 22424426 Free PMC article. Review.
Gottron's papules exhibit dermal accumulation of CD44 variant 7 (CD44v7) and its binding partner osteopontin: a unique molecular signature. Jessica S Kim, Muhammad M Bashir, Victoria P Werth. J Invest Dermatol, 2012 Mar 30; 132(7). PMID: 22456539 Free PMC article.
Matricellular proteins: a sticky affair with cancers. Han Chung Chong, Chek Kun Tan, Royston-Luke Huang, Nguan Soon Tan. J Oncol, 2012 Apr 07; 2012. PMID: 22481923 Free PMC article.
Matricellular proteins in cardiac adaptation and disease. Nikolaos G Frangogiannis. Physiol Rev, 2012 Apr 27; 92(2). PMID: 22535894 Free PMC article. Highly Cited. Review.
Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction. Patrícia S de Almeida Prado, Maria Fernanda Soares, +2 authors, Flávio O Lima, Nestor Schor, Vicente P C Teixeira. less Int J Exp Pathol, 2012 May 09; 93(3). PMID: 22563623 Free PMC article.
Osteopontin contributes to TGF-β1 mediated hepatic stellate cell activation. Xiao Xiao, Yi Gang, +10 authors, Daiming Fan. less Dig Dis Sci, 2012 Jun 05; 57(11). PMID: 22661273
Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway. Hsien-Te Chen, Hsi-Kai Tsou, Chia-Hao Chang, Chih-Hsin Tang. PLoS One, 2012 Jun 08; 7(6). PMID: 22675553 Free PMC article.
Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature. Machiko Hotta, Mitsuaki Ishida, +2 authors, Fumiyoshi Kojima, Yasuhiro Iwai, Hidetoshi Okabe. less Oncol Lett, 2011 May 01; 2(3). PMID: 22866100 Free PMC article.
Extracellular matrix and fibroblast communication following myocardial infarction. Yonggang Ma, Ganesh V Halade, Merry L Lindsey. J Cardiovasc Transl Res, 2012 Aug 29; 5(6). PMID: 22926488 Free PMC article. Review.
Osteopontin and other regulators of angiogenesis and fibrogenesis in the vitreous from patients with proliferative vitreoretinal disorders. Ahmed M Abu El-Asrar, Mohd Imtiaz Nawaz, +2 authors, Karel Geboes. less Mediators Inflamm, 2012 Oct 12; 2012. PMID: 23055574 Free PMC article.
CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients. Chun Yang, Hongyan Liang, Hongli Zhao, Xiaofeng Jiang. Exp Ther Med, 2012 Oct 13; 4(1). PMID: 23060926 Free PMC article.
CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis. Wakiro Sato, Atsuko Tomita, +9 authors, Takashi Yamamura. less J Immunol, 2012 Oct 17; 189(10). PMID: 23071279 Free PMC article.
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. Yasuto Yamaguchi, Zhifei Shao, +8 authors, Lawrence L K Leung. less J Biol Chem, 2012 Dec 04; 288(5). PMID: 23204518 Free PMC article.
Osteopontin: participation in inflammation or mucosal protection in inflammatory bowel diseases? Fengyuan Chen, Hongchun Liu, +5 authors, Shi-yao Chen. less Dig Dis Sci, 2013 Jan 31; 58(6). PMID: 23361573
Elevated circulating levels of osteopontin are associated with metastasis in advanced non-small cell lung cancer. Yong Liang, Hui Li, +8 authors, Sheng-Cai Hou. less Chin J Cancer Res, 2011 Mar 01; 23(1). PMID: 23467432 Free PMC article.
Irreversible renal damage after transient renin-angiotensin system stimulation: involvement of an AT1-receptor mediated immune response. Bart F J Heijnen, Jelly Nelissen, +7 authors, Harry A J Struijker-Boudier. less PLoS One, 2013 Mar 08; 8(2). PMID: 23469072 Free PMC article.
Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels. Kathryn J Schunke, Luke Coyle, Gary F Merrill, David T Denhardt. J Cell Physiol, 2013 Mar 26; 228(10). PMID: 23526585 Free PMC article.
Porous CaP/silk composite scaffolds to repair femur defects in an osteoporotic model. Ning Cheng, Jing Dai, +6 authors, Bin Shi. less J Mater Sci Mater Med, 2013 May 16; 24(8). PMID: 23674058 Free PMC article.
Oxygen nano-bubble water reduces calcium oxalate deposits and tubular cell injury in ethylene glycol-treated rat kidney. Yasuhiko Hirose, Takahiro Yasui, +10 authors, Kenjiro Kohri. less Urolithiasis, 2013 Jun 12; 41(4). PMID: 23754513
The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: role of endogenous TLR ligands. Kitipong Uaesoontrachoon, Hee-Jae Cha, +10 authors, Kanneboyina Nagaraju. less J Pathol, 2013 Jul 17; 231(2). PMID: 23857504 Free PMC article.
A prospective study of bone marrow hematopoietic and mesenchymal stem cells in type 1 Gaucher disease patients. Séverine Lecourt, Enguerran Mouly, +11 authors, Jérôme Larghero. less PLoS One, 2013 Aug 13; 8(7). PMID: 23935976 Free PMC article.
Gene expression profiling as a tool to investigate the molecular machinery activated during hippocampal neurodegeneration induced by trimethyltin (TMT) administration. Wanda Lattanzi, Valentina Corvino, +2 authors, Maria Concetta Geloso. less Int J Mol Sci, 2013 Aug 21; 14(8). PMID: 23955266 Free PMC article. Review.
Nasal administration of recombinant osteopontin attenuates early brain injury after subarachnoid hemorrhage. Basak Caner Topkoru, Orhan Altay, +3 authors, John H Zhang. less Stroke, 2013 Sep 07; 44(11). PMID: 24008574 Free PMC article.
Identification of an adipogenic niche for adipose tissue remodeling and restoration. Yun-Hee Lee, Anelia P Petkova, James G Granneman. Cell Metab, 2013 Sep 10; 18(3). PMID: 24011071 Free PMC article. Highly Cited.
Changes in mouse thymus and spleen after return from the STS-135 mission in space. Daila S Gridley, Xiao Wen Mao, +7 authors, Michael J Pecaut. less PLoS One, 2013 Sep 27; 8(9). PMID: 24069384 Free PMC article.
Transcriptome analysis of human peripheral blood mononuclear cells exposed to Lassa virus and to the attenuated Mopeia/Lassa reassortant 29 (ML29), a vaccine candidate. Juan Carlos Zapata, Ricardo Carrion, +9 authors, Maria S Salvato. less PLoS Negl Trop Dis, 2013 Sep 27; 7(9). PMID: 24069471 Free PMC article.
Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers. Thomas E Kruger, Andrew H Miller, Andrew K Godwin, Jinxi Wang. Crit Rev Oncol Hematol, 2013 Sep 28; 89(2). PMID: 24071501 Free PMC article. Review.
Adipose tissue immunity and cancer. Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Gema Frühbeck. Front Physiol, 2013 Oct 10; 4. PMID: 24106481 Free PMC article. Review.
High serum osteopontin levels are associated with low bone mineral density in postmenopausal women. Eun-Hee Cho, Keun-Hyok Cho, Hyang Ah Lee, Sang-Wook Kim. J Korean Med Sci, 2013 Oct 18; 28(10). PMID: 24133355 Free PMC article.
Osteopontin, inflammation and myogenesis: influencing regeneration, fibrosis and size of skeletal muscle. Charles N Pagel, Dimuthu K Wasgewatte Wijesinghe, Neda Taghavi Esfandouni, Eleanor J Mackie. J Cell Commun Signal, 2013 Dec 10; 8(2). PMID: 24318932 Free PMC article.
Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review. Subhash C Juneja, Christian Veillette. Arthritis, 2013 Dec 11; 2013. PMID: 24324885 Free PMC article. Review.
Tertiary structure prediction and identification of druggable pocket in the cancer biomarker - Osteopontin-c. Subramaniam Sivakumar, Sivasitambaram Niranjali Devaraj. J Diabetes Metab Disord, 2014 Jan 10; 13(1). PMID: 24401206 Free PMC article.
Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration. Megan C Wright, Ruifa Mi, +7 authors, Ahmet Höke. less J Neurosci, 2014 Jan 31; 34(5). PMID: 24478351 Free PMC article.
Suppression of osteopontin functions by levocetirizine, a histamine H1 receptor antagonist, in vitro. Toshimitsu Komatsuzaki, Isao Suzaki, +3 authors, Harumi Suzaki. less Biomed Res Int, 2014 Feb 04; 2013. PMID: 24490170 Free PMC article.
Osteopontin splice variant as a potential marker for metastatic disease in pancreatic adenocarcinoma. Ali A Siddiqui, Elizabeth Jones, +5 authors, Hwyda A Arafat. less J Gastroenterol Hepatol, 2014 Feb 20; 29(6). PMID: 24548099 Free PMC article.
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Evangelia Kourepini, Maria Aggelakopoulou, +3 authors, Vily Panoutsakopoulou. less Proc Natl Acad Sci U S A, 2014 Feb 20; 111(9). PMID: 24550510 Free PMC article.
Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage. Whitney L Barfield, Kitipong Uaesoontrachoon, +6 authors, Eric P Hoffman. less Hum Mol Genet, 2014 Mar 15; 23(15). PMID: 24626632 Free PMC article.
Immunohistochemical localization and mRNA quantification of osteopontin and Tamm-Horsfall protein in canine renal tissue after potassium oxalate injection. Walaa Mohamaden, Heng Wang, +2 authors, Huawei Guan, Xia Meng, Jianji Li. less BMC Vet Res, 2014 Mar 19; 10. PMID: 24628885 Free PMC article.
Osteopontin circulating levels correlate with renal involvement in systemic lupus erythematosus and are lower in ACE inhibitor-treated patients. Marco Quaglia, Annalisa Chiocchetti, +6 authors, Piero Stratta. less Clin Rheumatol, 2014 May 14; 33(9). PMID: 24820147
Association between secreted phosphoprotein-1 (SPP1) polymorphisms and low bone mineral density in women. Jen-Hau Chen, Yen-Ching Chen, +3 authors, Keh-Sung Tsai. less PLoS One, 2014 May 17; 9(5). PMID: 24831687 Free PMC article.
Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice. Andoni Lancha, Amaia Rodríguez, +7 authors, Javier Gómez-Ambrosi. less PLoS One, 2014 May 30; 9(5). PMID: 24871103 Free PMC article.
Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development. Pi-Ling Chang, Yu-Hua Hsieh, +5 authors, Kang-Jey Ho. less J Dermatol Sci, 2014 Jun 04; 75(2). PMID: 24888687 Free PMC article.
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes. Florian Kahles, Hannes M Findeisen, Dennis Bruemmer. Mol Metab, 2014 Jun 20; 3(4). PMID: 24944898 Free PMC article. Highly Cited. Review.
Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors. Kai-Hsi Hsu, Hung-Wen Tsai, +3 authors, Yan-Shen Shan. less World J Surg Oncol, 2014 Jun 21; 12. PMID: 24947165 Free PMC article.
Cardioprotective effects of osteopontin-1 during development of murine ischemic cardiomyopathy. Georg D Duerr, Bettina Mesenholl, +9 authors, Oliver Dewald. less Biomed Res Int, 2014 Jun 28; 2014. PMID: 24971311 Free PMC article.
Plasma levels of osteopontin and vascular endothelial growth factor in association with clinical features and parameters of tumor burden in patients with multiple myeloma. Toni Valković, Emina Babarović, +7 authors, Nives Jonjić. less Biomed Res Int, 2014 Jul 06; 2014. PMID: 24995304 Free PMC article.
Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients. Yue Qiu, Yuan Hu, +13 authors, Wei-Dong Du. less J Cancer Res Clin Oncol, 2014 Jul 11; 140(12). PMID: 25009318
Biomarkers in pulmonary arterial hypertension. Julie L Rosenthal, Miriam S Jacob. Curr Heart Fail Rep, 2014 Sep 19; 11(4). PMID: 25231874 Review.
S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis. Ahmed M Abu El-Asrar, Mohd Imtiaz Nawaz, +7 authors, Ghislain Opdenakker. less Mol Vis, 2014 Sep 26; 20. PMID: 25253987 Free PMC article.
Molecular biomarkers in idiopathic pulmonary fibrosis. Brett Ley, Kevin K Brown, Harold R Collard. Am J Physiol Lung Cell Mol Physiol, 2014 Sep 28; 307(9). PMID: 25260757 Free PMC article. Review.
Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells. I-Shan Hsieh, Rong-Sen Yang, Wen-Mei Fu. PLoS One, 2014 Oct 14; 9(10). PMID: 25310823 Free PMC article.
Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis. S Fortis, R G Khadaroo, J J Haitsma, H Zhang. Acta Anaesthesiol Scand, 2014 Oct 21; 59(2). PMID: 25328143 Free PMC article.
Evaluating the efficacy of osteopontin expression as a prognostic marker in oral squamous cell carcinoma in the Indian subpopulation. Yashwant Ingale, Samapika Routray, +2 authors, Supriya M Kheur, Mohit Kheur, Neeta Mohanty. less J Oral Maxillofac Pathol, 2014 Nov 05; 18(Suppl 1). PMID: 25364158 Free PMC article.
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury. Anna-Maj Albertsson, Xiaoli Zhang, +7 authors, Xiaoyang Wang. less J Neuroinflammation, 2014 Dec 04; 11. PMID: 25465048 Free PMC article.
Expression and purification of non-tagged recombinant mouse SPP1 in E. coli and its biological significance. Shunyan Weng, Liang Zhou, Lei Han, Yunsheng Yuan. Bioengineered, 2014 Dec 09; 5(6). PMID: 25482081 Free PMC article.
Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin. Maria Cecilia Garibaldi Marcondes, Ryan Ojakian, +3 authors, Howard S Fox. less Mediators Inflamm, 2014 Dec 20; 2014. PMID: 25525298 Free PMC article.
A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis. Shigeyuki Kon, Yosuke Nakayama, +7 authors, Toshimitsu Uede. less PLoS One, 2014 Dec 30; 9(12). PMID: 25545242 Free PMC article.
Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep. Greg A Johnson, Robert C Burghardt, Fuller W Bazer. J Anim Sci Biotechnol, 2015 Feb 12; 5(1). PMID: 25671104 Free PMC article. Review.
Current and potential applications of host-defense peptides and proteins in urology. Joey Chor Yee Lo, Dirk Lange. Biomed Res Int, 2015 Mar 31; 2015. PMID: 25815308 Free PMC article. Review.
Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis. Kavitha Mukund, Shankar Subramaniam. BMC Res Notes, 2015 May 04; 8. PMID: 25935398 Free PMC article.
Identification of therapeutic targets for glioblastoma by network analysis. D Friedmann-Morvinski, V Bhargava, +2 authors, S Gupta, I M Verma, S Subramaniam. less Oncogene, 2015 May 12; 35(5). PMID: 25961929 Free PMC article.
Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4. Monika Rabenstein, Joerg Hucklenbroich, +5 authors, Maria Adele Rueger. less Stem Cell Res Ther, 2015 May 23; 6. PMID: 25998490 Free PMC article.
Inflammatory and repair pathways induced in human bronchoalveolar lavage cells with ozone inhalation. Pascale Leroy, Andrea Tham, +6 authors, Mehrdad Arjomandi. less PLoS One, 2015 Jun 04; 10(6). PMID: 26035830 Free PMC article.
Role of plasma osteopontin as a biomarker in locally advanced breast cancer. Pieter H Anborgh, Laura Br Caria, +3 authors, Muriel Brackstone. less Am J Transl Res, 2015 Jun 13; 7(4). PMID: 26064440 Free PMC article.
Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma. Jules Lin, Amy L Myers, +12 authors, Lin Lin. less Oncotarget, 2015 Jun 13; 6(26). PMID: 26068949 Free PMC article.
SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis. Ayako Uchinaka, Yoshinosuke Hamada, +6 authors, Naomasa Kawaguchi. less Mol Cell Biochem, 2015 Jun 27; 408(1-2). PMID: 26112906
OPN -Revisited. Vijayanirmala Subraman, Muthukumar Thiyagarajan, N Malathi, Sharada T Rajan. J Clin Diagn Res, 2015 Aug 13; 9(6). PMID: 26266236 Free PMC article. Review.
Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy. Brandon J Dixon, Cesar Reis, +2 authors, Wing Mann Ho, Jiping Tang, John H Zhang. less Int J Mol Sci, 2015 Sep 22; 16(9). PMID: 26389893 Free PMC article. Review.
Identification and functional study of osteosarcoma metastasis marker genes. Rui Shi, Juan Li, +2 authors, Fan Tang, Y I Luo, Chong-Qi Tu. less Oncol Lett, 2015 Dec 02; 10(3). PMID: 26622763 Free PMC article.
Increased Expression of Osteopontin in the Degenerating Striatum of Rats Treated with Mitochondrial Toxin 3-Nitropropionic Acid: A Light and Electron Microscopy Study. Hong-Lim Kim, Mun-Yong Lee, +4 authors, Jong-Hwan Lee. less Acta Histochem Cytochem, 2015 Dec 04; 48(5). PMID: 26633905 Free PMC article.
The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts. Ying Wang, Jin Yang, +5 authors, You-Jin Lu. less Onco Targets Ther, 2015 Dec 10; 8. PMID: 26648743 Free PMC article.
Expression of Osteopontin in Oral Squamous Cell Carcinoma and its Surgical Margins-An Immunohistochemical Study. Vijaya Nirmala Subramani, Malathi Narasimhan, +2 authors, Logeswari Jayamani. less J Clin Diagn Res, 2015 Dec 18; 9(11). PMID: 26675878 Free PMC article.
Signature of cytokines and angiogenic factors (CAFs) defines a clinically distinct subgroup of gastric cancer. Chan-Young Ock, Ah-Rong Nam, +7 authors, Do-Youn Oh. less Gastric Cancer, 2015 Dec 19; 20(1). PMID: 26681196
The effects of immunomodulation by macrophage subsets on osteogenesis in vitro. Florence Loi, Luis A Córdova, +4 authors, Zhenyu Yao. less Stem Cell Res Ther, 2016 Jan 24; 7. PMID: 26801095 Free PMC article. Highly Cited.
The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors. Priscila Clara Calyjur, Camila de Freitas Almeida, +6 authors, Mariz Vainzof. less PLoS One, 2016 Mar 10; 11(3). PMID: 26954670 Free PMC article.
Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats. Jiang Wu, Yang Zhang, +8 authors, John H Zhang. less Stroke, 2016 Mar 24; 47(5). PMID: 27006454 Free PMC article.
Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression. A Ellert-Miklaszewska, P Wisniewski, +6 authors, B Kaminska. less Oncogene, 2016 Apr 05; 35(50). PMID: 27041573
The influence of calcitonin gene-related peptide on markers of bone metabolism in MG-63 osteoblast-like cells co-cultured with THP-1 macrophage-like cells under virtually osteolytic conditions. Heidrun Jablonski, Heike Rekasi, Marcus Jäger. BMC Musculoskelet Disord, 2016 May 05; 17. PMID: 27141814 Free PMC article.
Prognostic implication of antitumor immunity measured by the neutrophil-lymphocyte ratio and serum cytokines and angiogenic factors in gastric cancer. Chan-Young Ock, Ah-Rong Nam, +8 authors, Do-Youn Oh. less Gastric Cancer, 2016 May 06; 20(2). PMID: 27147244
Kidney Injury Molecule-1 Is Specifically Expressed in Cystically-Transformed Proximal Tubules of the PKD/Mhm (cy/+) Rat Model of Polycystic Kidney Disease. Stefan Gauer, Anja Urbschat, +4 authors, Nicholas Obermüller. less Int J Mol Sci, 2016 May 28; 17(6). PMID: 27231899 Free PMC article.
Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus. Joep van der Leeuw, Joline W J Beulens, +9 authors, Yvonne T van der Schouw. less J Am Heart Assoc, 2016 Jun 02; 5(6). PMID: 27247335 Free PMC article.
Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK. Suman Dalal, Qinqin Zha, Mahipal Singh, Krishna Singh. Mol Cell Biochem, 2016 Jun 06; 418(1-2). PMID: 27262843 Free PMC article.
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9. Yuta Morisaki, Mamiko Niikura, +10 authors, Hidemi Misawa. less Sci Rep, 2016 Jun 07; 6. PMID: 27264390 Free PMC article.
Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells. S Saleh, D E Thompson, +2 authors, J McConkey, P Murray, R A Moorehead. less BMC Cancer, 2016 Jun 11; 16. PMID: 27282619 Free PMC article.
Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients. Danny T M Leung, Pak-Leong Lim, +6 authors, Yick-Fu Wong. less PLoS One, 2016 Aug 06; 11(8). PMID: 27494141 Free PMC article.
Imatinib could be a new strategy for pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy in metastatic breast cancer. Ippei Fukada, Kazuhiro Araki, +6 authors, Yoshinori Ito. less Springerplus, 2016 Sep 22; 5(1). PMID: 27652155 Free PMC article.
Effect of Thyrotropin on Osteopontin, Integrin αvβ3, and VCAM-1 in the Endothelium via Activation of Akt. Yumeng Yan, Fengwei Jiang, +6 authors, Zhongyan Shan. less Int J Mol Sci, 2016 Sep 23; 17(9). PMID: 27657042 Free PMC article.
Cellular and Molecular Pathways Leading to External Root Resorption. A Iglesias-Linares, J K Hartsfield. J Dent Res, 2016 Nov 05; 96(2). PMID: 27811065 Free PMC article. Review.
Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial. Sophie E Rowbotham, Doug Cavaye, +7 authors, Jonathan Golledge. less Trials, 2017 Jan 05; 18(1). PMID: 28049491 Free PMC article.
Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases. Nausicaa Clemente, Davide Raineri, +7 authors, Annalisa Chiocchetti. less J Immunol Res, 2017 Jan 18; 2016. PMID: 28097158 Free PMC article. Review.
Osteopontin improves adhesion and migration of human primary renal cortical epithelial cells during wound healing. Jinfeng Wu, Zuolin Wang. Oncol Lett, 2017 Jan 20; 12(6). PMID: 28101213 Free PMC article.
The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis. Hadas Lavi, Miri Assayag, +3 authors, Neville Berkman. less PLoS One, 2017 Mar 03; 12(3). PMID: 28253271 Free PMC article.
Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy. Kinga I Gawlik, Johan Holmberg, +4 authors, Madeleine Durbeej. less Sci Rep, 2017 Mar 11; 7. PMID: 28281577 Free PMC article.
Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing. Koji Hosaka, Kelley Rojas, +6 authors, Brian Hoh. less Stroke, 2017 Mar 16; 48(4). PMID: 28292871 Free PMC article.
CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives. Lourdes Cortes-Dericks, Ralph Alexander Schmid. Respir Res, 2017 Apr 14; 18(1). PMID: 28403901 Free PMC article. Review.
Transcriptome analysis for the identification of cellular markers related to trabecular meshwork differentiation. Padmapriya Sathiyanathan, Cheryl Y Tay, Lawrence W Stanton. BMC Genomics, 2017 May 19; 18(1). PMID: 28514956 Free PMC article.
Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation. Jie Dong, Qiang Ma. Part Fibre Toxicol, 2017 Jun 10; 14(1). PMID: 28595626 Free PMC article.
The Effect of Osteopontin on Microglia. Huan Yu, Xiaohong Liu, Yisheng Zhong. Biomed Res Int, 2017 Jul 13; 2017. PMID: 28698867 Free PMC article. Review.
Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men. Tobias Feldreich, Axel C Carlsson, +4 authors, Johan Ärnlöv. less Cardiorenal Med, 2017 Jul 25; 7(3). PMID: 28736565 Free PMC article.
Osteopontin -- a promising biomarker for cancer therapy. Ran Wei, Janet Pik Ching Wong, Hang Fai Kwok. J Cancer, 2017 Aug 19; 8(12). PMID: 28819419 Free PMC article. Review.
The Retina of Osteopontin deficient Mice in Aging. Noelia Ruzafa, Xandra Pereiro, +2 authors, Patricia Aspichueta, Javier Araiz, Elena Vecino. less Mol Neurobiol, 2017 Sep 04; 55(1). PMID: 28866734 Free PMC article.
Combined analysis of the pre- and postoperative neutrophil-lymphocyte ratio predicts the outcomes of patients with gastric cancer. Kozo Miyatani, Hiroaki Saito, +7 authors, Yoshiyuki Fujiwara. less Surg Today, 2017 Sep 17; 48(3). PMID: 28916967
The role of α9β1 integrin and its ligands in the development of autoimmune diseases. Shigeyuki Kon, Toshimitsu Uede. J Cell Commun Signal, 2017 Oct 05; 12(1). PMID: 28975544 Free PMC article.
Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells. Neda Mazaheri, Maryam Peymani, +4 authors, Mohammad Hossein Nasr-Esfahani. less Cell Mol Neurobiol, 2017 Nov 08; 38(4). PMID: 29110207
Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer. Artur Anisiewicz, Agata Pawlik, +10 authors, Joanna Wietrzyk. less Int J Oncol, 2017 Nov 09; 52(1). PMID: 29115583 Free PMC article.
Angiotensin 1-7, but not the thrombin-cleaved osteopontin C-terminal fragment, attenuates osteopontin-mediated macrophage-induced endothelial-cell inflammation. Rachel Hamias, Assaf Rudich, +2 authors, George Greenberg, Gabriel Szendro, Talya Wolak. less Inflamm Res, 2017 Nov 29; 67(3). PMID: 29181544
Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production. Rachel M Brick, Aaron X Sun, Rocky S Tuan. Stem Cells Transl Med, 2017 Dec 08; 7(1). PMID: 29215199 Free PMC article.
Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases? Tomoya Iida, Kohei Wagatsuma, Daisuke Hirayama, Hiroshi Nakase. Int J Mol Sci, 2017 Dec 22; 19(1). PMID: 29267211 Free PMC article. Review.
Discovery of a Potential Plasma Protein Biomarker Panel for Acute-on-Chronic Liver Failure Induced by Hepatitis B Virus. Ni Zhou, Kuifeng Wang, +7 authors, Jiansheng Zhu. less Front Physiol, 2017 Dec 23; 8. PMID: 29270132 Free PMC article.
Serum osteopontin: a biomarker of disease activity and predictor of relapsing course in patients with giant cell arteritis. Potential clinical usefulness in tocilizumab-treated patients. Sergio Prieto-González, Nekane Terrades-García, +12 authors, Maria C Cid. less RMD Open, 2018 Jan 05; 3(2). PMID: 29299342 Free PMC article.
Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis. Elmira Agah, Arshia Zardoui, +3 authors, Nima Rezaei. less PLoS One, 2018 Jan 19; 13(1). PMID: 29346446 Free PMC article. Systematic Review.
Acute-Phase Plasma Osteopontin as an Independent Predictor for Poor Outcome After Aneurysmal Subarachnoid Hemorrhage. Yoshinari Nakatsuka, Masato Shiba, +5 authors, pSEED group. less Mol Neurobiol, 2018 Jan 22; 55(8). PMID: 29353454
Progress of Regenerative Therapy in Orthopedics. Pearlin, Sunita Nayak, Geetha Manivasagam, Dwaipayan Sen. Curr Osteoporos Rep, 2018 Mar 01; 16(2). PMID: 29488062 Review.
Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes. Xia Jin, Hua Xu, Michael S McGrath. PLoS One, 2018 Mar 15; 13(3). PMID: 29538412 Free PMC article.
Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage. Wenqian Zhang, Ying Cui, +5 authors, Jianzhong Cui. less Med Sci Monit, 2018 Mar 20; 24. PMID: 29550832 Free PMC article.
Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta. Christa Caesar, Alicia N Lyle, +5 authors, W Robert Taylor. less Cell Mol Bioeng, 2018 Mar 20; 10(2). PMID: 29552233 Free PMC article.
Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis. Nicola Graham, Bin-Zhi Qian. Int J Mol Sci, 2018 Apr 13; 19(4). PMID: 29642534 Free PMC article. Review.
Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection. Viviana Sampayo-Escobar, Ryan Green, +3 authors, Shyam S Mohapatra. less PLoS One, 2018 Apr 21; 13(4). PMID: 29677209 Free PMC article.
Different effects of global osteopontin and macrophage osteopontin in glomerular injury. Jessica Trostel, Luan D Truong, +10 authors, Gabriela E Garcia. less Am J Physiol Renal Physiol, 2018 May 03; 315(4). PMID: 29717936 Free PMC article.
Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage. Anne Z Eriksen, Rasmus Eliasen, +6 authors, Andrew J Urquhart. less ACS Nano, 2018 Jul 14; 12(8). PMID: 30004669 Free PMC article.
The Phylogeny of Osteopontin-Analysis of the Protein Sequence. Georg F Weber. Int J Mol Sci, 2018 Aug 30; 19(9). PMID: 30154395 Free PMC article.
Osteopontin controls immunosuppression in the tumor microenvironment. Michael R Shurin. J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395537 Free PMC article.
The prognostic significance of the comprehensive complication index in patients with gastric cancer. Shota Shimizu, Hiroaki Saito, +6 authors, Yoshiyuki Fujiwara. less Surg Today, 2019 May 31; 49(11). PMID: 31147763
Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche. Huimin Cao, Benjamin Cao, +7 authors, Susan K Nilsson. less Cells, 2019 Aug 30; 8(9). PMID: 31461896 Free PMC article.
The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis. Virender Kumar, Yuxiang Dong, +2 authors, Vinod Kumar, Saud Almawash, Ram I Mahato. less Theranostics, 2019 Nov 07; 9(25). PMID: 31695785 Free PMC article.
Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes. Monika Rabenstein, Marcus Unverricht-Yeboah, +11 authors, Maria Adele Rueger. less Front Cell Neurosci, 2019 Nov 12; 13. PMID: 31708742 Free PMC article.
Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk. Manuel F Landecho, Carlota Tuero, +3 authors, Gema Frühbeck. less Nutrients, 2019 Nov 07; 11(11). PMID: 31694146 Free PMC article. Review.
7-O-methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells. Manal Fardoun, Rabah Iratni, +7 authors, Elias Baydoun. less Biomolecules, 2019 Nov 14; 9(11). PMID: 31717401 Free PMC article.
Osteopontin expression is associated with progression and adverse prognosis in patients with resectable gastrointestinal stromal tumor. Jinhai Wang, Xiaobin Cheng, Sen Lu, Weina Fan. Int J Clin Exp Pathol, 2020 Jan 15; 12(4). PMID: 31933953 Free PMC article.
Brain Parenchymal and Extraparenchymal Macrophages in Development, Homeostasis, and Disease. Simone Brioschi, Yingyue Zhou, Marco Colonna. J Immunol, 2020 Jan 08; 204(2). PMID: 31907272 Free PMC article. Review.
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. Kate M Herum, Andreas Romaine, +13 authors, Geir Christensen. less J Am Heart Assoc, 2020 Feb 01; 9(3). PMID: 32000579 Free PMC article.
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis. Milica Krstic, Haider M Hassan, +6 authors, Alan B Tuck. less Lab Invest, 2019 Oct 02; 100(3). PMID: 31570773 Free PMC article.
Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1. Liying Shi, Lin Shi, Xiangdong Wang, Jiantai He. Cell Transplant, 2018 Jul 14; 27(8). PMID: 30001635 Free PMC article.
Acute intranasal osteopontin treatment in male rats following TBI increases the number of activated microglia but does not alter lesion characteristics. Amandine Jullienne, Mary Hamer, +7 authors, Andre Obenaus. less J Neurosci Res, 2019 Mar 21; 98(1). PMID: 30892744 Free PMC article.
The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin. Kiyoshi Hirahara, Ami Aoki, +3 authors, Toshinori Nakayama. less Semin Immunopathol, 2019 Apr 11; 41(3). PMID: 30968186 Review.
Exploration of pathophysiological pathways for incident atrial fibrillation using a multiplex proteomic chip. John Molvin, Amra Jujic, +8 authors, Martin Magnusson. less Open Heart, 2020 Mar 24; 7(1). PMID: 32201587 Free PMC article.
Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling. Margrit Hollborn, Ricarda Brück, +2 authors, Heidrun Kuhrt, Peter Wiedemann, Andreas Bringmann. less Mol Vis, 2020 Mar 28; 26. PMID: 32214785 Free PMC article.
Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke. Anne Ladwig, Rebecca Rogall, +6 authors, Michael Schroeter. less J Neuroimmune Pharmacol, 2018 Nov 30; 14(2). PMID: 30488353
Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice. Machiko Honda, Chiemi Kimura, Toshimitsu Uede, Shigeyuki Kon. J Cell Commun Signal, 2020 Feb 18; 14(2). PMID: 32062834 Free PMC article.
Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma. Salvatore Napoli, Chiara Scuderi, +5 authors, Luca Falzone. less Cells, 2020 May 13; 9(5). PMID: 32392801 Free PMC article. Review.
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression. Qiaozhi Wei, Fumio Nakahara, +10 authors, Paul S Frenette. less Dev Cell, 2020 May 16; 53(5). PMID: 32413329 Free PMC article.
Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation†. Natalie Quan, Lacey R Harris, +6 authors, Francesca E Duncan. less Biol Reprod, 2019 Aug 23; 102(1). PMID: 31436294 Free PMC article.
Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity. Rodney C P Go, Michael J Corley, +5 authors, Maarit I Tiirikainen. less BMC Neurosci, 2020 Jul 12; 21(1). PMID: 32650713 Free PMC article.
Osteopontin and Integrin Mediated Modulation of Post-Synapses in HIV Envelope Glycoprotein Exposed Hippocampal Neurons. Farina J Mahmud, Thomas Boucher, Shijun Liang, Amanda M Brown. Brain Sci, 2020 Jun 10; 10(6). PMID: 32512754 Free PMC article.
Osteopontin as a candidate of therapeutic application for the acute brain injury. Yunxiang Zhou, Yihan Yao, +3 authors, Anwen Shao. less J Cell Mol Med, 2020 Jul 14; 24(16). PMID: 32657030 Free PMC article. Review.
SPP1 promotes Schwann cell proliferation and survival through PKCα by binding with CD44 and αvβ3 after peripheral nerve injury. Jiang-Bo Wang, Zhan Zhang, +4 authors, Shu-Sen Cui. less Cell Biosci, 2020 Aug 28; 10. PMID: 32843960 Free PMC article.
Osteopontin: The Molecular Bridge between Fat and Cardiac-Renal Disorders. Elena Vianello, Marta Kalousová, +3 authors, Massimiliano Marco Corsi Romanelli. less Int J Mol Sci, 2020 Aug 08; 21(15). PMID: 32759639 Free PMC article. Review.
Pulmonary tumor thrombotic microangiopathy: a systematic review. Rohit H Godbole, Rajan Saggar, Nader Kamangar. Pulm Circ, 2019 Apr 30; 9(2). PMID: 31032740 Free PMC article.
Monocyte recruitment and activated inflammation are associated with thyroid carcinogenesis in a mouse model. Sunmi Park, Jack Zhu, Grégoire Altan-Bonnet, Sheue-Yann Cheng. Am J Cancer Res, 2019 Aug 09; 9(7). PMID: 31392080 Free PMC article.
Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep (Ovis aries). Hiu-Gwen Tsang, Emily L Clark, +5 authors, Kim M Summers. less Front Genet, 2020 Oct 27; 11. PMID: 33101359 Free PMC article.
External apical root resorption in orthodontic patients: molecular and genetic basis. Shilpa Kalra, Prateek Gupta, Tulika Tripathi, Priyank Rai. J Family Med Prim Care, 2020 Oct 29; 9(8). PMID: 33110782 Free PMC article. Review.
Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome. Dustin L Norton, Agathe Ceppe, +9 authors, Jason R Mock. less J Transl Med, 2020 Nov 13; 18(1). PMID: 33176790 Free PMC article.
Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls. Masayuki Hashimoto, Dongming Sun, +2 authors, Susan R Rittling, David T Denhardt, Wise Young. less J Neurosci, 2007 Mar 30; 27(13). PMID: 17392476 Free PMC article.
Osteopontin - a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease. Bogdan-Ioan Coculescu, Gheorghe Manole, +3 authors, Cristina Mariana Stocheci. less J Enzyme Inhib Med Chem, 2019 Mar 08; 34(1). PMID: 30843743 Free PMC article.
The Significance of Secreted Phosphoprotein 1 in Multiple Human Cancers. Tengteng Wei, Guoshu Bi, +9 authors, Donglin Zhu. less Front Mol Biosci, 2020 Dec 17; 7. PMID: 33324676 Free PMC article.
Expression of Extracellular Matrix-Related Genes and Their Regulatory microRNAs in Problematic Colorectal Polyps. Margareta Žlajpah, Emanuela Boštjančič, Bojan Tepeš, Nina Zidar. Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322258 Free PMC article.
The Roles of Osteopontin in the Pathogenesis of West Nile Encephalitis. Farzana Nazneen, Fengwei Bai. Vaccines (Basel), 2020 Dec 16; 8(4). PMID: 33317005 Free PMC article. Review.
Effects of Neurological Disorders on Bone Health. Ryan R Kelly, Sara J Sidles, Amanda C LaRue. Front Psychol, 2021 Jan 12; 11. PMID: 33424724 Free PMC article. Review.
Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis. James G Tidball, Ivan Flores, +2 authors, Eisuke Ochi. less Exp Gerontol, 2020 Dec 29; 145. PMID: 33359378 Free PMC article. Review.
Identification of Key Candidate Genes Involved in the Progression of Idiopathic Pulmonary Fibrosis. Yu Cui, Jie Ji, +2 authors, Jiwei Hou, Yi Tan, Xiaodong Han. less Molecules, 2021 Mar 07; 26(4). PMID: 33672678 Free PMC article.
Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix. Marta S Carvalho, Joaquim M S Cabral, Cláudia L da Silva, Deepak Vashishth. Polymers (Basel), 2021 Apr 04; 13(7). PMID: 33808184 Free PMC article. Review.
Osteopontin and osteoprotegerin in atherosclerotic plaque - are they significant markers of plaque vulnerability? Cristina Strobescu-Ciobanu, Simona Eliza Giuşcă, +5 authors, Cristian Dumitru Lupaşcu. less Rom J Morphol Embryol, 2021 Apr 06; 61(3). PMID: 33817720 Free PMC article.
The multifaceted progenitor fates in healthy or unhealthy adipose tissue during obesity. Geneviève Marcelin, Karine Clément. Rev Endocr Metab Disord, 2021 Jun 10; 22(4). PMID: 34105090 Review.
Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma. Masahiro Nishikawa, Akihiro Inoue, +12 authors, Takeharu Kunieda. less Transl Oncol, 2021 May 31; 14(8). PMID: 34052625 Free PMC article.
The Correlation Between SPP1 and Immune Escape of EGFR Mutant Lung Adenocarcinoma Was Explored by Bioinformatics Analysis. Yi Zheng, Shiying Hao, +6 authors, Yan Zhang. less Front Oncol, 2021 Jun 29; 11. PMID: 34178613 Free PMC article.
Bone-Derived Modulators That Regulate Brain Function: Emerging Therapeutic Targets for Neurological Disorders. Hongzhen Chen, Dewei Shang, Yuguan Wen, Chao Liang. Front Cell Dev Biol, 2021 Jun 29; 9. PMID: 34179014 Free PMC article. Review.
Molecular Biomarkers in Idiopathic Pulmonary Fibrosis: State of the Art and Future Directions. Anna Stainer, Paola Faverio, +5 authors, Fabrizio Luppi. less Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34200784 Free PMC article. Review.
Osteopontin in vitreous and idiopathic epiretinal membranes. Lucia Dinice, Andrea Cacciamani, +5 authors, Alessandra Micera. less Graefes Arch Clin Exp Ophthalmol, 2020 Apr 12; 258(7). PMID: 32277255
Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging. Michael Lekwuwa, Mayur Choudhary, Eleonora M Lad, Goldis Malek. Mod Pathol, 2021 Aug 15; 35(2). PMID: 34389792 Free PMC article.
Binding Mode Characterization of Osteopontin on Hydroxyapatite by Solution NMR Spectroscopy. Julian Holzinger, Harald Kotisch, Klaus W Richter, Robert Konrat. Chembiochem, 2021 Apr 30; 22(13). PMID: 33914399 Free PMC article.
Modeling of the Human Bone Environment: Mechanical Stimuli Guide Mesenchymal Stem Cell-Extracellular Matrix Interactions. Ana Rita Pereira, Andreas Lipphaus, +5 authors, Marietta Herrmann. less Materials (Basel), 2021 Aug 28; 14(16). PMID: 34442954 Free PMC article.
Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases. Toshio Hattori, Hiroko Iwasaki-Hozumi, +6 authors, Takashi Matsuba. less Biomedicines, 2021 Aug 28; 9(8). PMID: 34440210 Free PMC article. Review.
Th17-Related Cytokines as Potential Discriminatory Markers between Neuromyelitis Optica (Devic's Disease) and Multiple Sclerosis-A Review. Karina Maciak, Sylwia Pietrasik, +5 authors, Elzbieta Miller. less Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445668 Free PMC article. Review.
Current Therapies for Neonatal Hypoxic-Ischaemic and Infection-Sensitised Hypoxic-Ischaemic Brain Damage. Konstantina Tetorou, Claudia Sisa, +2 authors, Arzo Iqbal, Kim Dhillon, Mariya Hristova. less Front Synaptic Neurosci, 2021 Sep 11; 13. PMID: 34504417 Free PMC article. Review.
Histologic and molecular features in pathologic human menisci from knees with and without osteoarthritis. Farrah A Monibi, Tania Pannellini, +2 authors, Miguel Otero, Russell F Warren, Scott A Rodeo. less J Orthop Res, 2021 Apr 02; 40(2). PMID: 33792974 Free PMC article.
CSF Levels of CXCL12 and Osteopontin as Early Markers of Primary Progressive Multiple Sclerosis. Damiano Marastoni, Roberta Magliozzi, +6 authors, Massimiliano Calabrese. less Neurol Neuroimmunol Neuroinflamm, 2021 Oct 01; 8(6). PMID: 34588298 Free PMC article.
The Potential Role of Osteopontin in the Pathogenesis of Graves' Ophthalmopathy. Heng Lou, Lian-Qun Wu, +2 authors, Hao Wang, Rui-Li Wei, Jin-Wei Cheng. less Invest Ophthalmol Vis Sci, 2021 Sep 22; 62(12). PMID: 34546326 Free PMC article.
Osteopontin-derived synthetic peptide SVVYGLR upregulates functional regeneration of oral and maxillofacial soft-tissue injury. Susumu Tanaka, Yoshinosuke Hamada, +2 authors, Yuhki Yokoyama, Hirofumi Yamamoto, Mikihiko Kogo. less Jpn Dent Sci Rev, 2021 Oct 12; 57. PMID: 34630775 Free PMC article. Review.
White matter injury but not germinal matrix hemorrhage induces elevated osteopontin expression in human preterm brains. Gisela Nilsson, Ana A Baburamani, +5 authors, Xiaoyang Wang. less Acta Neuropathol Commun, 2021 Oct 17; 9(1). PMID: 34654477 Free PMC article.
Differential proteome profile, biological pathways, and network relationships of osteogenic proteins in calcified human aortic valves. Richard I Han, Chenyue W Hu, +8 authors, K Jane Grande-Allen. less Heart Vessels, 2021 Nov 03; 37(2). PMID: 34727208
Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages. Supriya Murthy, Isabel Karkossa, +8 authors, Manuela Rossol. less Cell Death Dis, 2022 Jan 14; 13(1). PMID: 35022393 Free PMC article.
Osteopontin is a biomarker for early autoimmune uveoretinitis. Jeongtae Kim, Meejung Ahn, +5 authors, Taekyun Shin. less Neural Regen Res, 2021 Dec 18; 17(7). PMID: 34916447 Free PMC article.
Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration. Sanako Makishi, Tomohiko Yamazaki, Hayato Ohshima. Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35162963 Free PMC article.
Osteopontin in autoimmune disorders: current knowledge and future perspective. Canhua Xu, Yaohong Wu, Ning Liu. Inflammopharmacology, 2022 Mar 03; 30(2). PMID: 35235108 Review.
Update on Multiple Sclerosis Molecular Biomarkers to Monitor Treatment Effects. Viviana Nociti, Marina Romozzi, Massimiliano Mirabella. J Pers Med, 2022 Apr 24; 12(4). PMID: 35455665 Free PMC article. Review.
Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. Sarah Rose Anderson, Jacqueline M Roberts, +5 authors, Monica L Vetter. less Elife, 2022 Apr 29; 11. PMID: 35481836 Free PMC article.

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