Review
. 2001 May; 107(9):1055-61.
doi: 10.1172/JCI12980.

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

D T Denhardt 1 M Noda  A W O'Regan  D Pavlin  J S Berman  
Affiliations
  • PMID: 11342566
  •     38 References
  •     320 citations

No abstract available

The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin.
Y Yokosaki, N Matsuura, +7 authors, D Sheppard.
J Biol Chem, 1999 Dec 14; 274(51). PMID: 10593924
Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin.
G J Nau, L Liaw, +3 authors, R A Young.
Infect Immun, 1999 Jul 23; 67(8). PMID: 10417195    Free PMC article.
Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.
S Ashkar, G F Weber, +7 authors, H Cantor.
Science, 2000 Feb 05; 287(5454). PMID: 10657301
Highly Cited.
Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor.
Y H Lin, C J Huang, +4 authors, H F Yang-Yen.
Mol Cell Biol, 2000 Mar 25; 20(8). PMID: 10733576    Free PMC article.
Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration.
R Zohar, N Suzuki, +4 authors, J Sodek.
J Cell Physiol, 2000 May 29; 184(1). PMID: 10825241
In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells.
K Asosingh, U Günthert, +5 authors, K Vanderkerken.
Cancer Res, 2000 Jun 13; 60(11). PMID: 10850462
The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin.
O Helluin, C Chan, +3 authors, J S Bennett.
J Biol Chem, 2000 Apr 07; 275(24). PMID: 10751402
Regulation of no synthesis induced by inflammatory mediators in RAW264.7 cells: collagen prevents inhibition by osteopontin.
J Y Tian, E S Sørensen, +4 authors, D T Denhardt.
Cytokine, 2000 Jun 17; 12(5). PMID: 10857758
Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).
B M Wittig, B Johansson, +2 authors, U Günthert.
J Exp Med, 2000 Jun 22; 191(12). PMID: 10859330    Free PMC article.
Osteopontin is induced by nitric oxide in RAW 264.7 cells.
F Takahashi, K Takahashi, +2 authors, Y Fukuchi.
IUBMB Life, 2000 Jun 27; 49(3). PMID: 10868913
Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection.
G J Nau, G L Chupp, +4 authors, R A Young.
Am J Pathol, 2000 Jul 06; 157(1). PMID: 10880373    Free PMC article.
Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification.
S Jono, C Peinado, C M Giachelli.
J Biol Chem, 2000 Apr 15; 275(26). PMID: 10766759
Analysis of the alpha4beta1 integrin-osteopontin interaction.
S T Barry, S B Ludbrook, E Murrison, C M Horgan.
Exp Cell Res, 2000 Jul 18; 258(2). PMID: 10896785
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
P K Petrow, K M Hummel, +8 authors, S Gay.
Arthritis Rheum, 2000 Jul 21; 43(7). PMID: 10902765
Phosphate is a specific signal for induction of osteopontin gene expression.
G R Beck, B Zerler, E Moran.
Proc Natl Acad Sci U S A, 2000 Jul 13; 97(15). PMID: 10890885    Free PMC article.
Highly Cited.
Mechanical loading stimulates differentiation of periodontal osteoblasts in a mouse osteoinduction model: effect on type I collagen and alkaline phosphatase genes.
D Pavlin, S B Dove, R Zadro, J Gluhak-Heinrich.
Calcif Tissue Int, 2000 Aug 02; 67(2). PMID: 10920222
Lack of in vivo function of osteopontin in experimental anti-GBM nephritis.
John Michael Bonvini, Ursula Schatzmann, +5 authors, Rudolf P Wüthrich.
J Am Soc Nephrol, 2000 Aug 31; 11(9). PMID: 10966489
Osteopontin.
J Sodek, B Ganss, M D McKee.
Crit Rev Oral Biol Med, 2000 Oct 06; 11(3). PMID: 11021631
Highly Cited. Review.
Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells.
A W O'Regan, J M Hayden, J S Berman.
J Leukoc Biol, 2000 Oct 19; 68(4). PMID: 11037970
Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone.
Y Asou, S R Rittling, +5 authors, M Noda.
Endocrinology, 2001 Feb 22; 142(3). PMID: 11181551
Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin.
M Ishijima, S R Rittling, +5 authors, M Noda.
J Exp Med, 2001 Feb 07; 193(3). PMID: 11157060    Free PMC article.
Osteopontin: an intrinsic inhibitor of inflammation in cartilage.
M G Attur, M N Dave, +5 authors, A R Amin.
Arthritis Rheum, 2001 Mar 27; 44(3). PMID: 11263772
Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation.
A O'Regan, J S Berman.
Int J Exp Pathol, 2001 Apr 12; 81(6). PMID: 11298186    Free PMC article.
Review.
Temporal pattern of stimulation of osteoblast-associated genes during mechanically-induced osteogenesis in vivo: early responses of osteocalcin and type I collagen.
D Pavlin, R Zadro, J Gluhak-Heinrich.
Connect Tissue Res, 2001 Nov 23; 42(2). PMID: 11718468
Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodeling bone.
R A Dodds, J R Connor, +4 authors, M Gowen.
J Bone Miner Res, 1995 Nov 01; 10(11). PMID: 8592943
Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.
D R Senger, S R Ledbetter, +3 authors, M Detmar.
Am J Pathol, 1996 Jul 01; 149(1). PMID: 8686754    Free PMC article.
Highly Cited.
Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures.
J Klein-Nulend, J Roelofsen, +2 authors, E H Burger.
J Cell Physiol, 1997 Feb 01; 170(2). PMID: 9009146
Altered wound healing in mice lacking a functional osteopontin gene (spp1).
L Liaw, D E Birk, +3 authors, B L Hogan.
J Clin Invest, 1998 Apr 29; 101(7). PMID: 9525990    Free PMC article.
Highly Cited.
Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin.
L L Smith, C M Giachelli.
Exp Cell Res, 1998 Jul 17; 242(1). PMID: 9665832
CD44 occupancy prevents macrophage multinucleation.
H Sterling, C Saginario, A Vignery.
J Cell Biol, 1998 Nov 13; 143(3). PMID: 9813101    Free PMC article.
Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissue.
J A Scott, M L Weir, +3 authors, D G McCormack.
Am J Physiol, 1998 Dec 09; 275(6). PMID: 9843827
CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.
Y U Katagiri, J Sleeman, +10 authors, T Uede.
Cancer Res, 1999 Jan 19; 59(1). PMID: 9892210
Osteopontin expression and function: role in bone remodeling.
D T Denhardt, M Noda.
J Cell Biochem Suppl, 1999 Jan 20; 30-31. PMID: 9893260
Review.
Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro.
A W O'Regan, G L Chupp, +3 authors, J S Berman.
J Immunol, 1999 Jan 23; 162(2). PMID: 9916729
Osteopontin function in pathology: lessons from osteopontin-deficient mice.
S R Rittling, D T Denhardt.
Exp Nephrol, 1999 Apr 24; 7(2). PMID: 10213864
Review.
Role of osteopontin in bone remodeling caused by mechanical stress.
K Terai, T Takano-Yamamoto, +7 authors, S Nomura.
J Bone Miner Res, 1999 Jun 03; 14(6). PMID: 10352091
Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption.
H Yoshitake, S R Rittling, D T Denhardt, M Noda.
Proc Natl Acad Sci U S A, 1999 Jul 08; 96(14). PMID: 10393964    Free PMC article.
Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease.
K N Cowan, P L Jones, M Rabinovitch.
J Clin Invest, 2000 Jan 05; 105(1). PMID: 10619858    Free PMC article.
Regulation of interactions between cells and extracellular matrix: a command performance on several stages.
E H Sage.
J Clin Invest, 2001 Apr 04; 107(7). PMID: 11285292    Free PMC article.
Review.
Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi.
Melissa R Potter, Susan R Rittling, +4 authors, Janis J Weis.
Infect Immun, 2002 Feb 21; 70(3). PMID: 11854223    Free PMC article.
Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.
Kenji Yumoto, Muneaki Ishijima, +7 authors, Masaki Noda.
Proc Natl Acad Sci U S A, 2002 Apr 04; 99(7). PMID: 11930008    Free PMC article.
CD9 is associated with leukemia inhibitory factor-mediated maintenance of embryonic stem cells.
Masahiro Oka, Kenichi Tagoku, +5 authors, Naohiro Terada.
Mol Biol Cell, 2002 Apr 16; 13(4). PMID: 11950938    Free PMC article.
The role of osteopontin in breast cancer: clinical and experimental studies.
A B Tuck, A F Chambers.
J Mammary Gland Biol Neoplasia, 2002 May 16; 6(4). PMID: 12013531
Review.
Large-scale gene-expression studies and the challenge of multiple sclerosis.
Sergio E Baranzini, Stephen L Hauser.
Genome Biol, 2002 Oct 10; 3(10). PMID: 12372148    Free PMC article.
Review.
Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression.
M A Chellaiah, N Kizer, +6 authors, K A Hruska.
Mol Biol Cell, 2003 Jan 17; 14(1). PMID: 12529435    Free PMC article.
Osteopontin and colon cancer progression.
Timothy J Yeatman, Ann F Chambers.
Clin Exp Metastasis, 2003 Mar 26; 20(1). PMID: 12650611
Review.
Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter.
David T Denhardt, Devra Mistretta, +4 authors, Susan R Rittling.
Clin Exp Metastasis, 2003 Mar 26; 20(1). PMID: 12650610
Review.
Expression profiling of cytokines and related genes in regenerating skeletal muscle after cardiotoxin injection: a role for osteopontin.
Akira Hirata, Satoru Masuda, +7 authors, Shin'ichi Takeda.
Am J Pathol, 2003 Jun 24; 163(1). PMID: 12819025    Free PMC article.
The first intron of the human osteopontin gene contains a C/EBP-beta-responsive enhancer.
Francesca Giacopelli, Nadia Rosatto, +3 authors, Roberto Ravazzolo.
Gene Expr, 2003 Jul 03; 11(2). PMID: 12837040    Free PMC article.
Matrix proteins.
Caren M Gundberg.
Osteoporos Int, 2003 Sep 25; 14 Suppl 5. PMID: 14504704
Review.
Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata.
M Zöller, P Freyschmidt-Paul, +3 authors, R Hoffmann.
Clin Exp Immunol, 2004 Mar 11; 135(3). PMID: 15008971    Free PMC article.
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
Dympna Harmey, Lovisa Hessle, +3 authors, José Luis Millán.
Am J Pathol, 2004 Mar 25; 164(4). PMID: 15039209    Free PMC article.
Highly Cited.
Osteopontin expression correlates with adhesive and metastatic potential in metastasis-inducing DNA-transfected rat mammary cell lines.
V E Moye, R Barraclough, C West, P S Rudland.
Br J Cancer, 2004 May 20; 90(9). PMID: 15150606    Free PMC article.
CD44 in cancer progression: adhesion, migration and growth regulation.
R Marhaba, M Zöller.
J Mol Histol, 2004 Sep 02; 35(3). PMID: 15339042
Highly Cited. Review.
Osteopontin is strongly expressed by alveolar macrophages in the lungs of acute respiratory distress syndrome.
Fumiyuki Takahashi, Kazuhisa Takahashi, +6 authors, Yoshinosuke Fukuchi.
Lung, 2004 Nov 06; 182(3). PMID: 15526756
Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice.
Lisa Cooper, Claire Johnson, Frank Burslem, Paul Martin.
Genome Biol, 2005 Jan 12; 6(1). PMID: 15642097    Free PMC article.
Differentiation, maturation, and survival of dendritic cells by osteopontin regulation.
Kodai Kawamura, Kazuhiro Iyonaga, +3 authors, Yutaka Sasaki.
Clin Diagn Lab Immunol, 2005 Jan 12; 12(1). PMID: 15643009    Free PMC article.
The cytokine osteopontin modulates the severity of rotavirus diarrhea.
Ellen E Rollo, Scott J Hempson, +6 authors, Robert D Shaw.
J Virol, 2005 Feb 26; 79(6). PMID: 15731245    Free PMC article.
Gene expression profiling in neurological disorders: toward a systems-level understanding of the brain.
Sergio E Baranzini.
Neuromolecular Med, 2005 Mar 23; 6(1). PMID: 15781975
Review.
Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications.
Brian Christensen, Mette S Nielsen, +2 authors, Esben S Sørensen.
Biochem J, 2005 May 05; 390(Pt 1). PMID: 15869464    Free PMC article.
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.
Sebastian Stier, Yon Ko, +8 authors, David T Scadden.
J Exp Med, 2005 Jun 02; 201(11). PMID: 15928197    Free PMC article.
Highly Cited.
Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer.
L Boldrini, V Donati, +8 authors, G Fontanini.
Br J Cancer, 2005 Aug 11; 93(4). PMID: 16091764    Free PMC article.
Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis.
Annie Pardo, Kevin Gibson, +8 authors, Naftali Kaminski.
PLoS Med, 2005 Sep 01; 2(9). PMID: 16128620    Free PMC article.
Highly Cited.
A polymorphic variant inside the osteopontin gene shows association with disease course in oligoarticular juvenile idiopathic arthritis.
R Marciano, F Giacopelli, +6 authors, P Picco.
Ann Rheum Dis, 2005 Sep 10; 65(5). PMID: 16150788    Free PMC article.
A distinctive alveolar macrophage activation state induced by cigarette smoking.
Prescott G Woodruff, Laura L Koth, +5 authors, David J Erle.
Am J Respir Crit Care Med, 2005 Sep 17; 172(11). PMID: 16166618    Free PMC article.
Short-term treatment with anti-CD44v7 antibody, but not CD44v4, restores the gut mucosa in established chronic dextran sulphate sodium (DSS)-induced colitis in mice.
S Farkas, M Hornung, +6 authors, B M Wittig.
Clin Exp Immunol, 2005 Oct 20; 142(2). PMID: 16232212    Free PMC article.
T-bet-dependent expression of osteopontin contributes to T cell polarization.
Mari L Shinohara, Marianne Jansson, +3 authors, Harvey Cantor.
Proc Natl Acad Sci U S A, 2005 Nov 16; 102(47). PMID: 16286640    Free PMC article.
Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice.
Gamze Kilic, Junfeng Wang, Beatriz Sosa-Pineda.
Dev Dyn, 2006 Mar 07; 235(6). PMID: 16518820    Free PMC article.
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.
Mari L Shinohara, Linrong Lu, +4 authors, Harvey Cantor.
Nat Immunol, 2006 Apr 11; 7(5). PMID: 16604075    Free PMC article.
Highly Cited.
Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation.
Subarna A Khan, Amy C Cook, +4 authors, David T Denhardt.
Clin Exp Metastasis, 2006 May 13; 22(8). PMID: 16691370
Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancer.
Alison L Allan, Rosamma George, +12 authors, Alan B Tuck.
Am J Pathol, 2006 Jul 04; 169(1). PMID: 16816376    Free PMC article.
Distinct immunohistochemical expression of osteopontin in the adult rat major salivary glands.
Nicholas Obermüller, Nikolaus Gassler, +4 authors, Stefan Gauer.
J Mol Histol, 2006 Jul 04; 37(1-2). PMID: 16817053
Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.
Ola Larsson, David M Perlman, +8 authors, Peter B Bitterman.
Nucleic Acids Res, 2006 Aug 29; 34(16). PMID: 16936314    Free PMC article.
Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect.
Michelle B Bowie, Kristen D McKnight, +3 authors, Connie J Eaves.
J Clin Invest, 2006 Oct 04; 116(10). PMID: 17016561    Free PMC article.
Highly Cited.
Osteopontin promotes pathologic mineralization in articular cartilage.
Ann K Rosenthal, Claudia M Gohr, Miwa Uzuki, Ikuko Masuda.
Matrix Biol, 2006 Nov 25; 26(2). PMID: 17123806    Free PMC article.
Osteopontin and cardiovascular system.
Hiroshi Okamoto.
Mol Cell Biochem, 2006 Dec 01; 300(1-2). PMID: 17136480
Review.
Vascular calcification and osteoporosis--from clinical observation towards molecular understanding.
L C Hofbauer, C C Brueck, +2 authors, H Dobnig.
Osteoporos Int, 2006 Dec 08; 18(3). PMID: 17151836
Review.
The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse.
Enrico Pedemonte, Federica Benvenuto, +4 authors, Sergio E Baranzini.
BMC Genomics, 2007 Mar 08; 8. PMID: 17341312    Free PMC article.
Ultrastructural and immunocytochemical analyses of osteopontin in reactionary and reparative dentine formed after extrusion of upper rat incisors.
Marcio Cajazeira Aguiar, Victor E Arana-Chavez.
J Anat, 2007 Apr 13; 210(4). PMID: 17428203    Free PMC article.
Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts.
Mika Suzuki, Evangeline Mose, Christine Galloy, David Tarin.
Am J Pathol, 2007 Jul 11; 171(2). PMID: 17620367    Free PMC article.
The conceptus increases secreted phosphoprotein 1 gene expression in the mouse uterus during the progression of decidualization mainly due to its effects on uterine natural killer cells.
Jennifer L Herington, Brent M Bany.
Reproduction, 2007 Jul 20; 133(6). PMID: 17636175    Free PMC article.
Role of osteopontin in neutrophil function.
Adeline Koh, Andre Paes Batista da Silva, +6 authors, Ron Zohar.
Immunology, 2007 Aug 08; 122(4). PMID: 17680800    Free PMC article.
Anti-inflammatory effects of alphav integrin antagonism in acute kidney allograft rejection.
Jens Bedke, Eva Kiss, +10 authors, Hermann-Josef Gröne.
Am J Pathol, 2007 Aug 19; 171(4). PMID: 17702892    Free PMC article.
Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production.
Kathryn X Wang, Yufang Shi, David T Denhardt.
Proc Natl Acad Sci U S A, 2007 Sep 06; 104(37). PMID: 17785423    Free PMC article.
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.
Takashi Nomiyama, Diego Perez-Tilve, +8 authors, Dennis Bruemmer.
J Clin Invest, 2007 Sep 08; 117(10). PMID: 17823662    Free PMC article.
Highly Cited.
Alteration of the expression of CD44 [corrected] isoforms in oral epithelia and saliva from patients with oral lichen planus.
Ponlatham Chaiyarit, Kobkan Thongprasom, +6 authors, Mantharop Chaimusig.
J Clin Immunol, 2007 Sep 12; 28(1). PMID: 17846873
Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
Chengjiang Gao, Zhiyong Mi, Hongtao Guo, Paul C Kuo.
Neoplasia, 2007 Sep 28; 9(9). PMID: 17898865    Free PMC article.
Osteopontin regulates actin cytoskeleton and contributes to cell proliferation in primary erythroblasts.
Jeong-Ah Kang, Ying Zhou, +9 authors, Amittha Wickrema.
J Biol Chem, 2008 Jan 05; 283(11). PMID: 18174176    Free PMC article.
Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring.
Ryoichi Mori, Tanya J Shaw, Paul Martin.
J Exp Med, 2008 Jan 09; 205(1). PMID: 18180311    Free PMC article.
Highly Cited.
Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke.
Kristian P Doyle, Tao Yang, +5 authors, Mary P Stenzel-Poore.
J Cereb Blood Flow Metab, 2008 Mar 28; 28(6). PMID: 18364727    Free PMC article.
Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness.
Lisa de las Fuentes, C Charles Gu, +6 authors, Víctor G Dávila-Román.
J Am Soc Echocardiogr, 2008 Apr 15; 21(8). PMID: 18406574    Free PMC article.
Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts.
Noriaki Ono, Kazuhisa Nakashima, +7 authors, Masaki Noda.
J Biol Chem, 2008 Apr 18; 283(28). PMID: 18417476    Free PMC article.
Regulated osteopontin expression by dendritic cells decisively affects their migratory capacity.
Guido Schulz, Andreas C Renkl, +2 authors, Johannes M Weiss.
J Invest Dermatol, 2008 May 02; 128(10). PMID: 18449212    Free PMC article.
Increased expression of monocyte CD44v6 correlates with the deveopment of encephalitis in rhesus macaques infected with simian immunodeficiency virus.
Maria Cecilia G Marcondes, Caroline M S Lanigan, +2 authors, Howard S Fox.
J Infect Dis, 2008 May 13; 197(11). PMID: 18471064    Free PMC article.
Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells.
Mari L Shinohara, Hye-Jung Kim, +2 authors, Harvey Cantor.
Proc Natl Acad Sci U S A, 2008 May 16; 105(20). PMID: 18480255    Free PMC article.
Characterization of osteopontin expression and function after status epilepticus.
Karin Borges, Marla Gearing, +4 authors, Raymond Dingledine.
Epilepsia, 2008 Jun 05; 49(10). PMID: 18522644    Free PMC article.
Expression and processing of small integrin-binding ligand N-linked glycoproteins in mouse odontoblastic cells.
Shuo Chen, Lei Chen, +5 authors, Mary MacDougall.
Arch Oral Biol, 2008 Jun 28; 53(9). PMID: 18582847    Free PMC article.
Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis.
Jiamu Du, Sheng Hou, +7 authors, Jianping Ding.
J Mol Biol, 2008 Aug 13; 382(4). PMID: 18694758    Free PMC article.
Osteopontin in sepsis: any role?
Marc Derive, Sébastien Gibot.
Intensive Care Med, 2008 Sep 23; 34(12). PMID: 18807010
Osteopontin regulates development and function of invariant natural killer T cells.
Hongyan Diao, Kazuya Iwabuchi, +8 authors, Toshimitsu Uede.
Proc Natl Acad Sci U S A, 2008 Oct 07; 105(41). PMID: 18836077    Free PMC article.
Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction.
Prasanna Krishnamurthy, J Thomas Peterson, +2 authors, Krishna Singh.
Mol Cell Biochem, 2008 Nov 04; 322(1-2). PMID: 18979185    Free PMC article.
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.
Gopal Murugaiyan, Akanksha Mittal, Howard L Weiner.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017937    Free PMC article.
Senescent stromal-derived osteopontin promotes preneoplastic cell growth.
Ermira Pazolli, Xianmin Luo, +8 authors, Sheila A Stewart.
Cancer Res, 2009 Jan 22; 69(3). PMID: 19155301    Free PMC article.
Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.
Jami Mandelin, Emme C K Lin, +7 authors, Renata Pasqualini.
Cancer, 2009 Feb 19; 115(8). PMID: 19224553    Free PMC article.
Matricellular proteins produced by melanocytes and melanomas: in search for functions.
Mizuho Fukunaga-Kalabis, Ademi Santiago-Walker, Meenhard Herlyn.
Cancer Microenviron, 2009 Mar 25; 1(1). PMID: 19308688    Free PMC article.
Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site.
Norihisa Nishimichi, Fumiko Higashikawa, +3 authors, Yasuyuki Yokosaki.
J Biol Chem, 2009 Apr 07; 284(22). PMID: 19346516    Free PMC article.
Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells.
Galina Chipitsyna, Qiaoke Gong, +8 authors, Hwyda A Arafat.
Int J Cancer, 2009 Apr 10; 125(2). PMID: 19358273    Free PMC article.
Osteopontin: a multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcification.
Hyun-Ju Cho, Hyun-Jai Cho, Hyo-Soo Kim.
Curr Atheroscler Rep, 2009 Apr 14; 11(3). PMID: 19361352
Review.
Association of plasma osteopontin levels with coronary calcification evaluated by tomographic coronary calcium scoring.
Muhammedullah Aryan, Alper Kepez, +7 authors, Ferhan Ozmen.
J Bone Miner Metab, 2009 Apr 15; 27(5). PMID: 19365701
IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice.
Qianli Yu, Randy Vazquez, +3 authors, Douglas F Larson.
Am J Physiol Heart Circ Physiol, 2009 May 12; 297(1). PMID: 19429811    Free PMC article.
Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model.
S Julien, G Picco, +6 authors, J M Burchell.
Br J Cancer, 2009 May 14; 100(11). PMID: 19436292    Free PMC article.
Effects of corticosteroids on osteopontin expression in a murine model of allergic asthma.
Masatsugu Kurokawa, Satoshi Konno, +11 authors, Mitsuru Adachi.
Int Arch Allergy Immunol, 2009 Jun 12; 149 Suppl 1. PMID: 19494498    Free PMC article.
Immune cells and angiogenesis.
Domenico Ribatti, Enrico Crivellato.
J Cell Mol Med, 2009 Jun 23; 13(9A). PMID: 19538473    Free PMC article.
Review.
Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma.
Jennifer Sullivan, Laurel Blair, +9 authors, Hwyda A Arafat.
Surgery, 2009 Jul 25; 146(2). PMID: 19628079    Free PMC article.
Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53.
Hyo-Jin Kim, Ho-June Lee, +9 authors, Yong-Keun Jung.
Proc Natl Acad Sci U S A, 2009 Aug 27; 106(36). PMID: 19706414    Free PMC article.
beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia.
Anna Hogmalm, Dean Sheppard, Urpo Lappalainen, Kristina Bry.
Am J Respir Cell Mol Biol, 2009 Sep 01; 43(1). PMID: 19717813    Free PMC article.
Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
Daniel J Schneider, Janci C Lindsay, +2 authors, Michael R Blackburn.
FASEB J, 2009 Sep 02; 24(1). PMID: 19720619    Free PMC article.
Osteopontin is not crucial to protective immunity during murine tuberculosis.
Gerritje J W van der Windt, Catharina W Wieland, +2 authors, Tom van der Poll.
Immunology, 2009 Sep 25; 128(1 Suppl). PMID: 19740338    Free PMC article.
Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis.
Karin Alain, Niel A Karrow, +3 authors, Nathalie Bissonnette.
BMC Genomics, 2009 Sep 22; 10. PMID: 19765294    Free PMC article.
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.
Shadi A Sharif, Xiaoyan Du, +8 authors, Lawrence L K Leung.
Arthritis Rheum, 2009 Oct 01; 60(10). PMID: 19790060    Free PMC article.
Mechanisms of intermittent hypoxia induced hypertension.
Laura V González Bosc, Thomas Resta, Benjimen Walker, Nancy L Kanagy.
J Cell Mol Med, 2009 Oct 13; 14(1-2). PMID: 19818095    Free PMC article.
Review.
Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGH.
Jin-Cai Wu, Bing-Sheng Sun, +2 authors, Lun-Xiu Qin.
J Cancer Res Clin Oncol, 2009 Oct 17; 136(4). PMID: 19834740
Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats.
Hidenori Suzuki, Robert Ayer, +5 authors, John H Zhang.
Crit Care Med, 2009 Oct 24; 38(2). PMID: 19851092    Free PMC article.
Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse.
Gul Zaman, Leanne K Saxon, +5 authors, Lance E Lanyon.
Bone, 2009 Oct 28; 46(3). PMID: 19857613    Free PMC article.
Antigen-specific induction of osteopontin contributes to the chronification of allergic contact dermatitis.
Anne M Seier, Andreas C Renkl, +7 authors, Johannes M Weiss.
Am J Pathol, 2009 Dec 17; 176(1). PMID: 20008129    Free PMC article.
Implication of expression of osteopontin and its receptor integrin alphanubeta3 in the placenta in the development of preeclampsia.
Junxia Xia, Fuyuan Qiao, Fangmin Su, Haiyi Liu.
J Huazhong Univ Sci Technolog Med Sci, 2009 Dec 29; 29(6). PMID: 20037822
Mechanisms of immune-mediated liver injury.
David H Adams, Cynthia Ju, +2 authors, Hartmut Jaeschke.
Toxicol Sci, 2010 Jan 15; 115(2). PMID: 20071422    Free PMC article.
Review.
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.
Donald Courter, Hongbin Cao, +10 authors, Quynh-Thu Le.
PLoS One, 2010 Mar 13; 5(3). PMID: 20224789    Free PMC article.
Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage.
Eva Kiss, Zoran V Popovic, +12 authors, Hermann-Josef Gröne.
Am J Pathol, 2010 Apr 07; 176(5). PMID: 20363918    Free PMC article.
Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists.
Wei Zhao, Lijuan Wang, +3 authors, Chengjiang Gao.
J Biol Chem, 2010 Apr 30; 285(27). PMID: 20427276    Free PMC article.
Recombinant osteopontin attenuates brain injury after intracerebral hemorrhage in mice.
Bihua Wu, Qingyi Ma, +4 authors, John Zhang.
Neurocrit Care, 2010 May 05; 14(1). PMID: 20440599
Apc(MIN) modulation of vitamin D secosteroid growth control.
Haibo Xu, Gary H Posner, Michael Stevenson, Frederick C Campbell.
Carcinogenesis, 2010 May 22; 31(8). PMID: 20488884    Free PMC article.
The differences between the localizations of MUC1, MUC5AC, MUC6 and osteopontin in quail proventriculus and gizzard may be a reflection of functional differences of stomach parts.
Narin Liman, Emel Alan, Güner Küçük Bayram.
J Anat, 2010 May 25; 217(1). PMID: 20492430    Free PMC article.
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells.
Wei Yan, Chunfa Qian, +8 authors, Yongping You.
Neuro Oncol, 2010 Jun 01; 12(8). PMID: 20511184    Free PMC article.
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.
Gopal Murugaiyan, Akanksha Mittal, Howard L Weiner.
Proc Natl Acad Sci U S A, 2010 Jun 11; 107(25). PMID: 20534530    Free PMC article.
Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin.
Melissa Lazar, Jennifer Sullivan, +7 authors, Hwyda A Arafat.
Surgery, 2010 Jun 29; 148(2). PMID: 20579680    Free PMC article.
Role of tissue inhibitor of metalloproteinases-1 in the development of autoimmune lymphoproliferation.
Elena Boggio, Manuela Indelicato, +6 authors, Annalisa Chiocchetti.
Haematologica, 2010 Jul 03; 95(11). PMID: 20595097    Free PMC article.
Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells.
Priyanka Sharma, Santosh Kumar, Gopal C Kundu.
Mol Cancer, 2010 Jul 09; 9. PMID: 20609221    Free PMC article.
Cleavage of osteopontin by matrix metalloproteinase-12 modulates experimental autoimmune encephalomyelitis disease in C57BL/6 mice.
Angelika Goncalves DaSilva, Lucy Liaw, V Wee Yong.
Am J Pathol, 2010 Jul 24; 177(3). PMID: 20651245    Free PMC article.
Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C.
Sai-ichi Tanaka, Takayoshi Sumioka, +6 authors, Shizuya Saika.
Mol Vis, 2010 Jul 29; 16. PMID: 20664686    Free PMC article.
Osteopontin overproduction is associated with progression of glomerular fibrosis in a rat model of anti-glomerular basement membrane glomerulonephritis.
Justin Merszei, Jean Wu, +4 authors, Ya-Huan Lou.
Am J Nephrol, 2010 Aug 18; 32(3). PMID: 20714131    Free PMC article.
Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis.
Cindy Zhou, Jean Wu, +4 authors, Ya-Huan Lou.
Am J Nephrol, 2010 Aug 20; 32(4). PMID: 20720406    Free PMC article.
Osteopontin regulates anabolic effect in human menopausal osteoporosis with intermittent parathyroid hormone treatment.
T-I Chiang, I-C Chang, +3 authors, Y-W Cheng.
Osteoporos Int, 2010 Aug 25; 22(2). PMID: 20734029
Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis).
Gerritje J W van der Windt, W Joost Wiersinga, +5 authors, Tom van der Poll.
PLoS Negl Trop Dis, 2010 Sep 09; 4(8). PMID: 20824216    Free PMC article.
Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells.
Melissa Lazar, Jennifer Sullivan, +8 authors, Hwyda A Arafat.
J Gastrointest Surg, 2010 Sep 09; 14(10). PMID: 20824368
Differential gene expression in well-healed and poorly healed experimental aneurysms after coil treatment.
Ramanathan Kadirvel, Yong-Hong Ding, +2 authors, David F Kallmes.
Radiology, 2010 Sep 11; 257(2). PMID: 20829543    Free PMC article.
The impact of the extracellular matrix on inflammation.
Lydia Sorokin.
Nat Rev Immunol, 2010 Sep 25; 10(10). PMID: 20865019
Highly Cited. Review.
Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.
Hongtao Guo, Zhiyong Mi, +2 authors, Paul C Kuo.
J Biol Chem, 2010 Oct 05; 285(48). PMID: 20889505    Free PMC article.
1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model.
Hyo-Jung Lee, Soo-Jin Jeong, +4 authors, Sung-Hoon Kim.
Kidney Int, 2010 Nov 19; 79(5). PMID: 21085110    Free PMC article.
Genes and abdominal aortic aneurysm.
Irene Hinterseher, Gerard Tromp, Helena Kuivaniemi.
Ann Vasc Surg, 2010 Dec 15; 25(3). PMID: 21146954    Free PMC article.
Review.
Molecular mechanisms underlying hypothermia-induced neuroprotection.
Yasushi Shintani, Yasuko Terao, Hiroyuki Ohta.
Stroke Res Treat, 2010 Dec 15; 2011. PMID: 21151700    Free PMC article.
Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice.
Kyeong-Nam Yu, Arash Minai-Tehrani, +15 authors, Myung-Haing Cho.
PLoS One, 2011 Jan 05; 5(12). PMID: 21203518    Free PMC article.
NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages.
Wei Zhao, Lijuan Wang, +7 authors, Chengjiang Gao.
J Immunol, 2011 Jan 25; 186(5). PMID: 21257959    Free PMC article.
Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model.
Wanqiu Chen, Qingyi Ma, +3 authors, John H Zhang.
Stroke, 2011 Jan 29; 42(3). PMID: 21273567    Free PMC article.
Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen.
Sunanda S Baliga, Gary F Merrill, Mari L Shinohara, David T Denhardt.
PLoS One, 2011 Feb 02; 6(1). PMID: 21283687    Free PMC article.
Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1.
Norihisa Nishimichi, Hiromi Hayashita-Kinoh, +3 authors, Yasuyuki Yokosaki.
J Biol Chem, 2011 Feb 16; 286(13). PMID: 21321126    Free PMC article.
Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes.
Ahmed M Abu El-Asrar, Luc Missotten, Karel Geboes.
Mol Vis, 2011 Mar 03; 17. PMID: 21365018    Free PMC article.
Perinatal exposure to low-dose DE-71 increases serum thyroid hormones and gonadal osteopontin gene expression.
Charles A Blake, George L McCoy, Yvonne Y Hui, Holly A LaVoie.
Exp Biol Med (Maywood), 2011 Mar 04; 236(4). PMID: 21367881    Free PMC article.
Hematopoietic derived cell infiltration of the intestinal tumor microenvironment in Apc Min/+ mice.
Celestia Davis, Robert Price, +4 authors, Maria Marjorette O Peña.
Microsc Microanal, 2011 Apr 09; 17(4). PMID: 21473808    Free PMC article.
Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology.
Maki Morishita, Noriaki Ono, +12 authors, Masaki Noda.
Tissue Cell, 2011 Apr 23; 43(3). PMID: 21511320    Free PMC article.
Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls.
Paolo Poggio, Juan B Grau, +4 authors, Giovanni Ferrari.
J Cell Physiol, 2011 Apr 27; 226(8). PMID: 21520066    Free PMC article.
Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway.
Xianmin Luo, Megan K Ruhland, +2 authors, Sheila A Stewart.
Mol Cancer Res, 2011 Jun 16; 9(8). PMID: 21673011    Free PMC article.
Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye.
Uttio Roy Chowdhury, Seung-Youn Jea, +2 authors, Michael P Fautsch.
Invest Ophthalmol Vis Sci, 2011 Jul 12; 52(9). PMID: 21743018    Free PMC article.
Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis: the crosstalk between bone and adipose tissue.
Majid Assadi, Hooman Salimipour, +7 authors, Iraj Nabipour.
PLoS One, 2011 Sep 22; 6(9). PMID: 21935388    Free PMC article.
Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice.
Petrus Jansen van Vuren, Caroline T Tiemessen, Janusz T Paweska.
PLoS One, 2011 Sep 29; 6(9). PMID: 21949840    Free PMC article.
Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling.
Raquel Urtasun, Aritz Lopategi, +6 authors, Natalia Nieto.
Hepatology, 2011 Sep 29; 55(2). PMID: 21953216    Free PMC article.
The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity.
Cedric Hunter, Jennifer Bond, +2 authors, Howard Levinson.
J Surg Res, 2011 Oct 04; 176(1). PMID: 21962803    Free PMC article.
Sympathetic control of bone mass regulated by osteopontin.
Masashi Nagao, Timothy N Feinstein, +16 authors, Masaki Noda.
Proc Natl Acad Sci U S A, 2011 Oct 13; 108(43). PMID: 21990347    Free PMC article.
Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells.
Kate S Arbon, Cody M Christensen, Wendy A Harvey, Sara J Heggland.
Food Chem Toxicol, 2011 Oct 25; 50(2). PMID: 22019892    Free PMC article.
Overlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functions.
Loredana Frasca, Roberto Lande.
ScientificWorldJournal, 2011 Nov 30; 11. PMID: 22125457    Free PMC article.
Review.
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema.
Ming Shan, Xiaoyi Yuan, +9 authors, Farrah Kheradmand.
Sci Transl Med, 2012 Jan 21; 4(117). PMID: 22261033    Free PMC article.
NF-κB and matrix-dependent regulation of osteopontin promoter activity in allylamine-activated vascular smooth muscle cells.
E Spencer Williams, Emily Wilson, Kenneth S Ramos.
Oxid Med Cell Longev, 2012 Feb 09; 2012. PMID: 22315656    Free PMC article.
Peripheral blood biomarkers in idiopathic pulmonary fibrosis.
Rekha Vij, Imre Noth.
Transl Res, 2012 Mar 20; 159(4). PMID: 22424426    Free PMC article.
Review.
Gottron's papules exhibit dermal accumulation of CD44 variant 7 (CD44v7) and its binding partner osteopontin: a unique molecular signature.
Jessica S Kim, Muhammad M Bashir, Victoria P Werth.
J Invest Dermatol, 2012 Mar 30; 132(7). PMID: 22456539    Free PMC article.
Matricellular proteins: a sticky affair with cancers.
Han Chung Chong, Chek Kun Tan, Royston-Luke Huang, Nguan Soon Tan.
J Oncol, 2012 Apr 07; 2012. PMID: 22481923    Free PMC article.
Matricellular proteins in cardiac adaptation and disease.
Nikolaos G Frangogiannis.
Physiol Rev, 2012 Apr 27; 92(2). PMID: 22535894    Free PMC article.
Highly Cited. Review.
Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction.
Patrícia S de Almeida Prado, Maria Fernanda Soares, +2 authors, Vicente P C Teixeira.
Int J Exp Pathol, 2012 May 09; 93(3). PMID: 22563623    Free PMC article.
Osteopontin contributes to TGF-β1 mediated hepatic stellate cell activation.
Xiao Xiao, Yi Gang, +10 authors, Daiming Fan.
Dig Dis Sci, 2012 Jun 05; 57(11). PMID: 22661273
Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway.
Hsien-Te Chen, Hsi-Kai Tsou, Chia-Hao Chang, Chih-Hsin Tang.
PLoS One, 2012 Jun 08; 7(6). PMID: 22675553    Free PMC article.
Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature.
Machiko Hotta, Mitsuaki Ishida, +2 authors, Hidetoshi Okabe.
Oncol Lett, 2011 May 01; 2(3). PMID: 22866100    Free PMC article.
Extracellular matrix and fibroblast communication following myocardial infarction.
Yonggang Ma, Ganesh V Halade, Merry L Lindsey.
J Cardiovasc Transl Res, 2012 Aug 29; 5(6). PMID: 22926488    Free PMC article.
Review.
Osteopontin and other regulators of angiogenesis and fibrogenesis in the vitreous from patients with proliferative vitreoretinal disorders.
Ahmed M Abu El-Asrar, Mohd Imtiaz Nawaz, +2 authors, Karel Geboes.
Mediators Inflamm, 2012 Oct 12; 2012. PMID: 23055574    Free PMC article.
CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients.
Chun Yang, Hongyan Liang, Hongli Zhao, Xiaofeng Jiang.
Exp Ther Med, 2012 Oct 13; 4(1). PMID: 23060926    Free PMC article.
CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis.
Wakiro Sato, Atsuko Tomita, +9 authors, Takashi Yamamura.
J Immunol, 2012 Oct 17; 189(10). PMID: 23071279    Free PMC article.
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
Yasuto Yamaguchi, Zhifei Shao, +8 authors, Lawrence L K Leung.
J Biol Chem, 2012 Dec 04; 288(5). PMID: 23204518    Free PMC article.
Osteopontin: participation in inflammation or mucosal protection in inflammatory bowel diseases?
Fengyuan Chen, Hongchun Liu, +5 authors, Shi-yao Chen.
Dig Dis Sci, 2013 Jan 31; 58(6). PMID: 23361573
Elevated circulating levels of osteopontin are associated with metastasis in advanced non-small cell lung cancer.
Yong Liang, Hui Li, +8 authors, Sheng-Cai Hou.
Chin J Cancer Res, 2011 Mar 01; 23(1). PMID: 23467432    Free PMC article.
Irreversible renal damage after transient renin-angiotensin system stimulation: involvement of an AT1-receptor mediated immune response.
Bart F J Heijnen, Jelly Nelissen, +7 authors, Harry A J Struijker-Boudier.
PLoS One, 2013 Mar 08; 8(2). PMID: 23469072    Free PMC article.
Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels.
Kathryn J Schunke, Luke Coyle, Gary F Merrill, David T Denhardt.
J Cell Physiol, 2013 Mar 26; 228(10). PMID: 23526585    Free PMC article.
Porous CaP/silk composite scaffolds to repair femur defects in an osteoporotic model.
Ning Cheng, Jing Dai, +6 authors, Bin Shi.
J Mater Sci Mater Med, 2013 May 16; 24(8). PMID: 23674058    Free PMC article.
Oxygen nano-bubble water reduces calcium oxalate deposits and tubular cell injury in ethylene glycol-treated rat kidney.
Yasuhiko Hirose, Takahiro Yasui, +10 authors, Kenjiro Kohri.
Urolithiasis, 2013 Jun 12; 41(4). PMID: 23754513
The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: role of endogenous TLR ligands.
Kitipong Uaesoontrachoon, Hee-Jae Cha, +10 authors, Kanneboyina Nagaraju.
J Pathol, 2013 Jul 17; 231(2). PMID: 23857504    Free PMC article.
A prospective study of bone marrow hematopoietic and mesenchymal stem cells in type 1 Gaucher disease patients.
Séverine Lecourt, Enguerran Mouly, +11 authors, Jérôme Larghero.
PLoS One, 2013 Aug 13; 8(7). PMID: 23935976    Free PMC article.
Gene expression profiling as a tool to investigate the molecular machinery activated during hippocampal neurodegeneration induced by trimethyltin (TMT) administration.
Wanda Lattanzi, Valentina Corvino, +2 authors, Maria Concetta Geloso.
Int J Mol Sci, 2013 Aug 21; 14(8). PMID: 23955266    Free PMC article.
Review.
Nasal administration of recombinant osteopontin attenuates early brain injury after subarachnoid hemorrhage.
Basak Caner Topkoru, Orhan Altay, +3 authors, John H Zhang.
Stroke, 2013 Sep 07; 44(11). PMID: 24008574    Free PMC article.
Identification of an adipogenic niche for adipose tissue remodeling and restoration.
Yun-Hee Lee, Anelia P Petkova, James G Granneman.
Cell Metab, 2013 Sep 10; 18(3). PMID: 24011071    Free PMC article.
Highly Cited.
Changes in mouse thymus and spleen after return from the STS-135 mission in space.
Daila S Gridley, Xiao Wen Mao, +7 authors, Michael J Pecaut.
PLoS One, 2013 Sep 27; 8(9). PMID: 24069384    Free PMC article.
Transcriptome analysis of human peripheral blood mononuclear cells exposed to Lassa virus and to the attenuated Mopeia/Lassa reassortant 29 (ML29), a vaccine candidate.
Juan Carlos Zapata, Ricardo Carrion, +9 authors, Maria S Salvato.
PLoS Negl Trop Dis, 2013 Sep 27; 7(9). PMID: 24069471    Free PMC article.
Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers.
Thomas E Kruger, Andrew H Miller, Andrew K Godwin, Jinxi Wang.
Crit Rev Oncol Hematol, 2013 Sep 28; 89(2). PMID: 24071501    Free PMC article.
Review.
Adipose tissue immunity and cancer.
Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Gema Frühbeck.
Front Physiol, 2013 Oct 10; 4. PMID: 24106481    Free PMC article.
Review.
High serum osteopontin levels are associated with low bone mineral density in postmenopausal women.
Eun-Hee Cho, Keun-Hyok Cho, Hyang Ah Lee, Sang-Wook Kim.
J Korean Med Sci, 2013 Oct 18; 28(10). PMID: 24133355    Free PMC article.
Osteopontin, inflammation and myogenesis: influencing regeneration, fibrosis and size of skeletal muscle.
Charles N Pagel, Dimuthu K Wasgewatte Wijesinghe, Neda Taghavi Esfandouni, Eleanor J Mackie.
J Cell Commun Signal, 2013 Dec 10; 8(2). PMID: 24318932    Free PMC article.
Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review.
Subhash C Juneja, Christian Veillette.
Arthritis, 2013 Dec 11; 2013. PMID: 24324885    Free PMC article.
Review.
Tertiary structure prediction and identification of druggable pocket in the cancer biomarker - Osteopontin-c.
Subramaniam Sivakumar, Sivasitambaram Niranjali Devaraj.
J Diabetes Metab Disord, 2014 Jan 10; 13(1). PMID: 24401206    Free PMC article.
Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration.
Megan C Wright, Ruifa Mi, +7 authors, Ahmet Höke.
J Neurosci, 2014 Jan 31; 34(5). PMID: 24478351    Free PMC article.
Suppression of osteopontin functions by levocetirizine, a histamine H1 receptor antagonist, in vitro.
Toshimitsu Komatsuzaki, Isao Suzaki, +3 authors, Harumi Suzaki.
Biomed Res Int, 2014 Feb 04; 2013. PMID: 24490170    Free PMC article.
Osteopontin splice variant as a potential marker for metastatic disease in pancreatic adenocarcinoma.
Ali A Siddiqui, Elizabeth Jones, +5 authors, Hwyda A Arafat.
J Gastroenterol Hepatol, 2014 Feb 20; 29(6). PMID: 24548099    Free PMC article.
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation.
Evangelia Kourepini, Maria Aggelakopoulou, +3 authors, Vily Panoutsakopoulou.
Proc Natl Acad Sci U S A, 2014 Feb 20; 111(9). PMID: 24550510    Free PMC article.
Eccentric muscle challenge shows osteopontin polymorphism modulation of muscle damage.
Whitney L Barfield, Kitipong Uaesoontrachoon, +6 authors, Eric P Hoffman.
Hum Mol Genet, 2014 Mar 15; 23(15). PMID: 24626632    Free PMC article.
Immunohistochemical localization and mRNA quantification of osteopontin and Tamm-Horsfall protein in canine renal tissue after potassium oxalate injection.
Walaa Mohamaden, Heng Wang, +2 authors, Jianji Li.
BMC Vet Res, 2014 Mar 19; 10. PMID: 24628885    Free PMC article.
Osteopontin circulating levels correlate with renal involvement in systemic lupus erythematosus and are lower in ACE inhibitor-treated patients.
Marco Quaglia, Annalisa Chiocchetti, +6 authors, Piero Stratta.
Clin Rheumatol, 2014 May 14; 33(9). PMID: 24820147
Association between secreted phosphoprotein-1 (SPP1) polymorphisms and low bone mineral density in women.
Jen-Hau Chen, Yen-Ching Chen, +3 authors, Keh-Sung Tsai.
PLoS One, 2014 May 17; 9(5). PMID: 24831687    Free PMC article.
Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice.
Andoni Lancha, Amaia Rodríguez, +7 authors, Javier Gómez-Ambrosi.
PLoS One, 2014 May 30; 9(5). PMID: 24871103    Free PMC article.
Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development.
Pi-Ling Chang, Yu-Hua Hsieh, +5 authors, Kang-Jey Ho.
J Dermatol Sci, 2014 Jun 04; 75(2). PMID: 24888687    Free PMC article.
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.
Florian Kahles, Hannes M Findeisen, Dennis Bruemmer.
Mol Metab, 2014 Jun 20; 3(4). PMID: 24944898    Free PMC article.
Highly Cited. Review.
Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors.
Kai-Hsi Hsu, Hung-Wen Tsai, +3 authors, Yan-Shen Shan.
World J Surg Oncol, 2014 Jun 21; 12. PMID: 24947165    Free PMC article.
Cardioprotective effects of osteopontin-1 during development of murine ischemic cardiomyopathy.
Georg D Duerr, Bettina Mesenholl, +9 authors, Oliver Dewald.
Biomed Res Int, 2014 Jun 28; 2014. PMID: 24971311    Free PMC article.
Plasma levels of osteopontin and vascular endothelial growth factor in association with clinical features and parameters of tumor burden in patients with multiple myeloma.
Toni Valković, Emina Babarović, +7 authors, Nives Jonjić.
Biomed Res Int, 2014 Jul 06; 2014. PMID: 24995304    Free PMC article.
Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients.
Yue Qiu, Yuan Hu, +13 authors, Wei-Dong Du.
J Cancer Res Clin Oncol, 2014 Jul 11; 140(12). PMID: 25009318
Biomarkers in pulmonary arterial hypertension.
Julie L Rosenthal, Miriam S Jacob.
Curr Heart Fail Rep, 2014 Sep 19; 11(4). PMID: 25231874
Review.
S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis.
Ahmed M Abu El-Asrar, Mohd Imtiaz Nawaz, +7 authors, Ghislain Opdenakker.
Mol Vis, 2014 Sep 26; 20. PMID: 25253987    Free PMC article.
Molecular biomarkers in idiopathic pulmonary fibrosis.
Brett Ley, Kevin K Brown, Harold R Collard.
Am J Physiol Lung Cell Mol Physiol, 2014 Sep 28; 307(9). PMID: 25260757    Free PMC article.
Review.
Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells.
I-Shan Hsieh, Rong-Sen Yang, Wen-Mei Fu.
PLoS One, 2014 Oct 14; 9(10). PMID: 25310823    Free PMC article.
Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis.
S Fortis, R G Khadaroo, J J Haitsma, H Zhang.
Acta Anaesthesiol Scand, 2014 Oct 21; 59(2). PMID: 25328143    Free PMC article.
Evaluating the efficacy of osteopontin expression as a prognostic marker in oral squamous cell carcinoma in the Indian subpopulation.
Yashwant Ingale, Samapika Routray, +2 authors, Neeta Mohanty.
J Oral Maxillofac Pathol, 2014 Nov 05; 18(Suppl 1). PMID: 25364158    Free PMC article.
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury.
Anna-Maj Albertsson, Xiaoli Zhang, +7 authors, Xiaoyang Wang.
J Neuroinflammation, 2014 Dec 04; 11. PMID: 25465048    Free PMC article.
Expression and purification of non-tagged recombinant mouse SPP1 in E. coli and its biological significance.
Shunyan Weng, Liang Zhou, Lei Han, Yunsheng Yuan.
Bioengineered, 2014 Dec 09; 5(6). PMID: 25482081    Free PMC article.
Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin.
Maria Cecilia Garibaldi Marcondes, Ryan Ojakian, +3 authors, Howard S Fox.
Mediators Inflamm, 2014 Dec 20; 2014. PMID: 25525298    Free PMC article.
A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis.
Shigeyuki Kon, Yosuke Nakayama, +7 authors, Toshimitsu Uede.
PLoS One, 2014 Dec 30; 9(12). PMID: 25545242    Free PMC article.
Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep.
Greg A Johnson, Robert C Burghardt, Fuller W Bazer.
J Anim Sci Biotechnol, 2015 Feb 12; 5(1). PMID: 25671104    Free PMC article.
Review.
Current and potential applications of host-defense peptides and proteins in urology.
Joey Chor Yee Lo, Dirk Lange.
Biomed Res Int, 2015 Mar 31; 2015. PMID: 25815308    Free PMC article.
Review.
Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis.
Kavitha Mukund, Shankar Subramaniam.
BMC Res Notes, 2015 May 04; 8. PMID: 25935398    Free PMC article.
Identification of therapeutic targets for glioblastoma by network analysis.
D Friedmann-Morvinski, V Bhargava, +2 authors, S Subramaniam.
Oncogene, 2015 May 12; 35(5). PMID: 25961929    Free PMC article.
Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4.
Monika Rabenstein, Joerg Hucklenbroich, +5 authors, Maria Adele Rueger.
Stem Cell Res Ther, 2015 May 23; 6. PMID: 25998490    Free PMC article.
Inflammatory and repair pathways induced in human bronchoalveolar lavage cells with ozone inhalation.
Pascale Leroy, Andrea Tham, +6 authors, Mehrdad Arjomandi.
PLoS One, 2015 Jun 04; 10(6). PMID: 26035830    Free PMC article.
Role of plasma osteopontin as a biomarker in locally advanced breast cancer.
Pieter H Anborgh, Laura Br Caria, +3 authors, Muriel Brackstone.
Am J Transl Res, 2015 Jun 13; 7(4). PMID: 26064440    Free PMC article.
Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma.
Jules Lin, Amy L Myers, +12 authors, Lin Lin.
Oncotarget, 2015 Jun 13; 6(26). PMID: 26068949    Free PMC article.
SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis.
Ayako Uchinaka, Yoshinosuke Hamada, +6 authors, Naomasa Kawaguchi.
Mol Cell Biochem, 2015 Jun 27; 408(1-2). PMID: 26112906
OPN -Revisited.
Vijayanirmala Subraman, Muthukumar Thiyagarajan, N Malathi, Sharada T Rajan.
J Clin Diagn Res, 2015 Aug 13; 9(6). PMID: 26266236    Free PMC article.
Review.
Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy.
Brandon J Dixon, Cesar Reis, +2 authors, John H Zhang.
Int J Mol Sci, 2015 Sep 22; 16(9). PMID: 26389893    Free PMC article.
Review.
Identification and functional study of osteosarcoma metastasis marker genes.
Rui Shi, Juan Li, +2 authors, Chong-Qi Tu.
Oncol Lett, 2015 Dec 02; 10(3). PMID: 26622763    Free PMC article.
Increased Expression of Osteopontin in the Degenerating Striatum of Rats Treated with Mitochondrial Toxin 3-Nitropropionic Acid: A Light and Electron Microscopy Study.
Hong-Lim Kim, Mun-Yong Lee, +4 authors, Jong-Hwan Lee.
Acta Histochem Cytochem, 2015 Dec 04; 48(5). PMID: 26633905    Free PMC article.
The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts.
Ying Wang, Jin Yang, +5 authors, You-Jin Lu.
Onco Targets Ther, 2015 Dec 10; 8. PMID: 26648743    Free PMC article.
Expression of Osteopontin in Oral Squamous Cell Carcinoma and its Surgical Margins-An Immunohistochemical Study.
Vijaya Nirmala Subramani, Malathi Narasimhan, +2 authors, Logeswari Jayamani.
J Clin Diagn Res, 2015 Dec 18; 9(11). PMID: 26675878    Free PMC article.
Signature of cytokines and angiogenic factors (CAFs) defines a clinically distinct subgroup of gastric cancer.
Chan-Young Ock, Ah-Rong Nam, +7 authors, Do-Youn Oh.
Gastric Cancer, 2015 Dec 19; 20(1). PMID: 26681196
The effects of immunomodulation by macrophage subsets on osteogenesis in vitro.
Florence Loi, Luis A Córdova, +4 authors, Zhenyu Yao.
Stem Cell Res Ther, 2016 Jan 24; 7. PMID: 26801095    Free PMC article.
Highly Cited.
The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors.
Priscila Clara Calyjur, Camila de Freitas Almeida, +6 authors, Mariz Vainzof.
PLoS One, 2016 Mar 10; 11(3). PMID: 26954670    Free PMC article.
Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats.
Jiang Wu, Yang Zhang, +8 authors, John H Zhang.
Stroke, 2016 Mar 24; 47(5). PMID: 27006454    Free PMC article.
Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression.
A Ellert-Miklaszewska, P Wisniewski, +6 authors, B Kaminska.
Oncogene, 2016 Apr 05; 35(50). PMID: 27041573
The influence of calcitonin gene-related peptide on markers of bone metabolism in MG-63 osteoblast-like cells co-cultured with THP-1 macrophage-like cells under virtually osteolytic conditions.
Heidrun Jablonski, Heike Rekasi, Marcus Jäger.
BMC Musculoskelet Disord, 2016 May 05; 17. PMID: 27141814    Free PMC article.
Prognostic implication of antitumor immunity measured by the neutrophil-lymphocyte ratio and serum cytokines and angiogenic factors in gastric cancer.
Chan-Young Ock, Ah-Rong Nam, +8 authors, Do-Youn Oh.
Gastric Cancer, 2016 May 06; 20(2). PMID: 27147244
Kidney Injury Molecule-1 Is Specifically Expressed in Cystically-Transformed Proximal Tubules of the PKD/Mhm (cy/+) Rat Model of Polycystic Kidney Disease.
Stefan Gauer, Anja Urbschat, +4 authors, Nicholas Obermüller.
Int J Mol Sci, 2016 May 28; 17(6). PMID: 27231899    Free PMC article.
Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus.
Joep van der Leeuw, Joline W J Beulens, +9 authors, Yvonne T van der Schouw.
J Am Heart Assoc, 2016 Jun 02; 5(6). PMID: 27247335    Free PMC article.
Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK.
Suman Dalal, Qinqin Zha, Mahipal Singh, Krishna Singh.
Mol Cell Biochem, 2016 Jun 06; 418(1-2). PMID: 27262843    Free PMC article.
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.
Yuta Morisaki, Mamiko Niikura, +10 authors, Hidemi Misawa.
Sci Rep, 2016 Jun 07; 6. PMID: 27264390    Free PMC article.
Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells.
S Saleh, D E Thompson, +2 authors, R A Moorehead.
BMC Cancer, 2016 Jun 11; 16. PMID: 27282619    Free PMC article.
Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients.
Danny T M Leung, Pak-Leong Lim, +6 authors, Yick-Fu Wong.
PLoS One, 2016 Aug 06; 11(8). PMID: 27494141    Free PMC article.
Imatinib could be a new strategy for pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy in metastatic breast cancer.
Ippei Fukada, Kazuhiro Araki, +6 authors, Yoshinori Ito.
Springerplus, 2016 Sep 22; 5(1). PMID: 27652155    Free PMC article.
Effect of Thyrotropin on Osteopontin, Integrin αvβ3, and VCAM-1 in the Endothelium via Activation of Akt.
Yumeng Yan, Fengwei Jiang, +6 authors, Zhongyan Shan.
Int J Mol Sci, 2016 Sep 23; 17(9). PMID: 27657042    Free PMC article.
Cellular and Molecular Pathways Leading to External Root Resorption.
A Iglesias-Linares, J K Hartsfield.
J Dent Res, 2016 Nov 05; 96(2). PMID: 27811065    Free PMC article.
Review.
Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial.
Sophie E Rowbotham, Doug Cavaye, +7 authors, Jonathan Golledge.
Trials, 2017 Jan 05; 18(1). PMID: 28049491    Free PMC article.
Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases.
Nausicaa Clemente, Davide Raineri, +7 authors, Annalisa Chiocchetti.
J Immunol Res, 2017 Jan 18; 2016. PMID: 28097158    Free PMC article.
Review.
Osteopontin improves adhesion and migration of human primary renal cortical epithelial cells during wound healing.
Jinfeng Wu, Zuolin Wang.
Oncol Lett, 2017 Jan 20; 12(6). PMID: 28101213    Free PMC article.
The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis.
Hadas Lavi, Miri Assayag, +3 authors, Neville Berkman.
PLoS One, 2017 Mar 03; 12(3). PMID: 28253271    Free PMC article.
Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy.
Kinga I Gawlik, Johan Holmberg, +4 authors, Madeleine Durbeej.
Sci Rep, 2017 Mar 11; 7. PMID: 28281577    Free PMC article.
Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing.
Koji Hosaka, Kelley Rojas, +6 authors, Brian Hoh.
Stroke, 2017 Mar 16; 48(4). PMID: 28292871    Free PMC article.
CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives.
Lourdes Cortes-Dericks, Ralph Alexander Schmid.
Respir Res, 2017 Apr 14; 18(1). PMID: 28403901    Free PMC article.
Review.
Transcriptome analysis for the identification of cellular markers related to trabecular meshwork differentiation.
Padmapriya Sathiyanathan, Cheryl Y Tay, Lawrence W Stanton.
BMC Genomics, 2017 May 19; 18(1). PMID: 28514956    Free PMC article.
Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation.
Jie Dong, Qiang Ma.
Part Fibre Toxicol, 2017 Jun 10; 14(1). PMID: 28595626    Free PMC article.
The Effect of Osteopontin on Microglia.
Huan Yu, Xiaohong Liu, Yisheng Zhong.
Biomed Res Int, 2017 Jul 13; 2017. PMID: 28698867    Free PMC article.
Review.
Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men.
Tobias Feldreich, Axel C Carlsson, +4 authors, Johan Ärnlöv.
Cardiorenal Med, 2017 Jul 25; 7(3). PMID: 28736565    Free PMC article.
Osteopontin -- a promising biomarker for cancer therapy.
Ran Wei, Janet Pik Ching Wong, Hang Fai Kwok.
J Cancer, 2017 Aug 19; 8(12). PMID: 28819419    Free PMC article.
Review.
The Retina of Osteopontin deficient Mice in Aging.
Noelia Ruzafa, Xandra Pereiro, +2 authors, Elena Vecino.
Mol Neurobiol, 2017 Sep 04; 55(1). PMID: 28866734    Free PMC article.
Combined analysis of the pre- and postoperative neutrophil-lymphocyte ratio predicts the outcomes of patients with gastric cancer.
Kozo Miyatani, Hiroaki Saito, +7 authors, Yoshiyuki Fujiwara.
Surg Today, 2017 Sep 17; 48(3). PMID: 28916967
The role of α9β1 integrin and its ligands in the development of autoimmune diseases.
Shigeyuki Kon, Toshimitsu Uede.
J Cell Commun Signal, 2017 Oct 05; 12(1). PMID: 28975544    Free PMC article.
Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells.
Neda Mazaheri, Maryam Peymani, +4 authors, Mohammad Hossein Nasr-Esfahani.
Cell Mol Neurobiol, 2017 Nov 08; 38(4). PMID: 29110207
Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer.
Artur Anisiewicz, Agata Pawlik, +10 authors, Joanna Wietrzyk.
Int J Oncol, 2017 Nov 09; 52(1). PMID: 29115583    Free PMC article.
Angiotensin 1-7, but not the thrombin-cleaved osteopontin C-terminal fragment, attenuates osteopontin-mediated macrophage-induced endothelial-cell inflammation.
Rachel Hamias, Assaf Rudich, +2 authors, Talya Wolak.
Inflamm Res, 2017 Nov 29; 67(3). PMID: 29181544
Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production.
Rachel M Brick, Aaron X Sun, Rocky S Tuan.
Stem Cells Transl Med, 2017 Dec 08; 7(1). PMID: 29215199    Free PMC article.
Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?
Tomoya Iida, Kohei Wagatsuma, Daisuke Hirayama, Hiroshi Nakase.
Int J Mol Sci, 2017 Dec 22; 19(1). PMID: 29267211    Free PMC article.
Review.
Discovery of a Potential Plasma Protein Biomarker Panel for Acute-on-Chronic Liver Failure Induced by Hepatitis B Virus.
Ni Zhou, Kuifeng Wang, +7 authors, Jiansheng Zhu.
Front Physiol, 2017 Dec 23; 8. PMID: 29270132    Free PMC article.
Serum osteopontin: a biomarker of disease activity and predictor of relapsing course in patients with giant cell arteritis. Potential clinical usefulness in tocilizumab-treated patients.
Sergio Prieto-González, Nekane Terrades-García, +12 authors, Maria C Cid.
RMD Open, 2018 Jan 05; 3(2). PMID: 29299342    Free PMC article.
Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis.
Elmira Agah, Arshia Zardoui, +3 authors, Nima Rezaei.
PLoS One, 2018 Jan 19; 13(1). PMID: 29346446    Free PMC article.
Systematic Review.
Acute-Phase Plasma Osteopontin as an Independent Predictor for Poor Outcome After Aneurysmal Subarachnoid Hemorrhage.
Yoshinari Nakatsuka, Masato Shiba, +5 authors, pSEED group.
Mol Neurobiol, 2018 Jan 22; 55(8). PMID: 29353454
Progress of Regenerative Therapy in Orthopedics.
Pearlin, Sunita Nayak, Geetha Manivasagam, Dwaipayan Sen.
Curr Osteoporos Rep, 2018 Mar 01; 16(2). PMID: 29488062
Review.
Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes.
Xia Jin, Hua Xu, Michael S McGrath.
PLoS One, 2018 Mar 15; 13(3). PMID: 29538412    Free PMC article.
Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage.
Wenqian Zhang, Ying Cui, +5 authors, Jianzhong Cui.
Med Sci Monit, 2018 Mar 20; 24. PMID: 29550832    Free PMC article.
Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta.
Christa Caesar, Alicia N Lyle, +5 authors, W Robert Taylor.
Cell Mol Bioeng, 2018 Mar 20; 10(2). PMID: 29552233    Free PMC article.
Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis.
Nicola Graham, Bin-Zhi Qian.
Int J Mol Sci, 2018 Apr 13; 19(4). PMID: 29642534    Free PMC article.
Review.
Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection.
Viviana Sampayo-Escobar, Ryan Green, +3 authors, Shyam S Mohapatra.
PLoS One, 2018 Apr 21; 13(4). PMID: 29677209    Free PMC article.
Different effects of global osteopontin and macrophage osteopontin in glomerular injury.
Jessica Trostel, Luan D Truong, +10 authors, Gabriela E Garcia.
Am J Physiol Renal Physiol, 2018 May 03; 315(4). PMID: 29717936    Free PMC article.
Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage.
Anne Z Eriksen, Rasmus Eliasen, +6 authors, Andrew J Urquhart.
ACS Nano, 2018 Jul 14; 12(8). PMID: 30004669    Free PMC article.
The Phylogeny of Osteopontin-Analysis of the Protein Sequence.
Georg F Weber.
Int J Mol Sci, 2018 Aug 30; 19(9). PMID: 30154395    Free PMC article.
Osteopontin controls immunosuppression in the tumor microenvironment.
Michael R Shurin.
J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395537    Free PMC article.
The prognostic significance of the comprehensive complication index in patients with gastric cancer.
Shota Shimizu, Hiroaki Saito, +6 authors, Yoshiyuki Fujiwara.
Surg Today, 2019 May 31; 49(11). PMID: 31147763
Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche.
Huimin Cao, Benjamin Cao, +7 authors, Susan K Nilsson.
Cells, 2019 Aug 30; 8(9). PMID: 31461896    Free PMC article.
The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis.
Virender Kumar, Yuxiang Dong, +2 authors, Ram I Mahato.
Theranostics, 2019 Nov 07; 9(25). PMID: 31695785    Free PMC article.
Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes.
Monika Rabenstein, Marcus Unverricht-Yeboah, +11 authors, Maria Adele Rueger.
Front Cell Neurosci, 2019 Nov 12; 13. PMID: 31708742    Free PMC article.
Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk.
Manuel F Landecho, Carlota Tuero, +3 authors, Gema Frühbeck.
Nutrients, 2019 Nov 07; 11(11). PMID: 31694146    Free PMC article.
Review.
7-O-methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells.
Manal Fardoun, Rabah Iratni, +7 authors, Elias Baydoun.
Biomolecules, 2019 Nov 14; 9(11). PMID: 31717401    Free PMC article.
Osteopontin expression is associated with progression and adverse prognosis in patients with resectable gastrointestinal stromal tumor.
Jinhai Wang, Xiaobin Cheng, Sen Lu, Weina Fan.
Int J Clin Exp Pathol, 2020 Jan 15; 12(4). PMID: 31933953    Free PMC article.
Brain Parenchymal and Extraparenchymal Macrophages in Development, Homeostasis, and Disease.
Simone Brioschi, Yingyue Zhou, Marco Colonna.
J Immunol, 2020 Jan 08; 204(2). PMID: 31907272    Free PMC article.
Review.
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin.
Kate M Herum, Andreas Romaine, +13 authors, Geir Christensen.
J Am Heart Assoc, 2020 Feb 01; 9(3). PMID: 32000579    Free PMC article.
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis.
Milica Krstic, Haider M Hassan, +6 authors, Alan B Tuck.
Lab Invest, 2019 Oct 02; 100(3). PMID: 31570773    Free PMC article.
Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1.
Liying Shi, Lin Shi, Xiangdong Wang, Jiantai He.
Cell Transplant, 2018 Jul 14; 27(8). PMID: 30001635    Free PMC article.
Acute intranasal osteopontin treatment in male rats following TBI increases the number of activated microglia but does not alter lesion characteristics.
Amandine Jullienne, Mary Hamer, +7 authors, Andre Obenaus.
J Neurosci Res, 2019 Mar 21; 98(1). PMID: 30892744    Free PMC article.
The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin.
Kiyoshi Hirahara, Ami Aoki, +3 authors, Toshinori Nakayama.
Semin Immunopathol, 2019 Apr 11; 41(3). PMID: 30968186
Review.
Exploration of pathophysiological pathways for incident atrial fibrillation using a multiplex proteomic chip.
John Molvin, Amra Jujic, +8 authors, Martin Magnusson.
Open Heart, 2020 Mar 24; 7(1). PMID: 32201587    Free PMC article.
Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling.
Margrit Hollborn, Ricarda Brück, +2 authors, Andreas Bringmann.
Mol Vis, 2020 Mar 28; 26. PMID: 32214785    Free PMC article.
Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke.
Anne Ladwig, Rebecca Rogall, +6 authors, Michael Schroeter.
J Neuroimmune Pharmacol, 2018 Nov 30; 14(2). PMID: 30488353
Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice.
Machiko Honda, Chiemi Kimura, Toshimitsu Uede, Shigeyuki Kon.
J Cell Commun Signal, 2020 Feb 18; 14(2). PMID: 32062834    Free PMC article.
Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma.
Salvatore Napoli, Chiara Scuderi, +5 authors, Luca Falzone.
Cells, 2020 May 13; 9(5). PMID: 32392801    Free PMC article.
Review.
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Qiaozhi Wei, Fumio Nakahara, +10 authors, Paul S Frenette.
Dev Cell, 2020 May 16; 53(5). PMID: 32413329    Free PMC article.
Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation†.
Natalie Quan, Lacey R Harris, +6 authors, Francesca E Duncan.
Biol Reprod, 2019 Aug 23; 102(1). PMID: 31436294    Free PMC article.
Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity.
Rodney C P Go, Michael J Corley, +5 authors, Maarit I Tiirikainen.
BMC Neurosci, 2020 Jul 12; 21(1). PMID: 32650713    Free PMC article.
Osteopontin and Integrin Mediated Modulation of Post-Synapses in HIV Envelope Glycoprotein Exposed Hippocampal Neurons.
Farina J Mahmud, Thomas Boucher, Shijun Liang, Amanda M Brown.
Brain Sci, 2020 Jun 10; 10(6). PMID: 32512754    Free PMC article.
Osteopontin as a candidate of therapeutic application for the acute brain injury.
Yunxiang Zhou, Yihan Yao, +3 authors, Anwen Shao.
J Cell Mol Med, 2020 Jul 14; 24(16). PMID: 32657030    Free PMC article.
Review.
SPP1 promotes Schwann cell proliferation and survival through PKCα by binding with CD44 and αvβ3 after peripheral nerve injury.
Jiang-Bo Wang, Zhan Zhang, +4 authors, Shu-Sen Cui.
Cell Biosci, 2020 Aug 28; 10. PMID: 32843960    Free PMC article.
Osteopontin: The Molecular Bridge between Fat and Cardiac-Renal Disorders.
Elena Vianello, Marta Kalousová, +3 authors, Massimiliano Marco Corsi Romanelli.
Int J Mol Sci, 2020 Aug 08; 21(15). PMID: 32759639    Free PMC article.
Review.
Pulmonary tumor thrombotic microangiopathy: a systematic review.
Rohit H Godbole, Rajan Saggar, Nader Kamangar.
Pulm Circ, 2019 Apr 30; 9(2). PMID: 31032740    Free PMC article.
Monocyte recruitment and activated inflammation are associated with thyroid carcinogenesis in a mouse model.
Sunmi Park, Jack Zhu, Grégoire Altan-Bonnet, Sheue-Yann Cheng.
Am J Cancer Res, 2019 Aug 09; 9(7). PMID: 31392080    Free PMC article.
Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep (Ovis aries).
Hiu-Gwen Tsang, Emily L Clark, +5 authors, Kim M Summers.
Front Genet, 2020 Oct 27; 11. PMID: 33101359    Free PMC article.
External apical root resorption in orthodontic patients: molecular and genetic basis.
Shilpa Kalra, Prateek Gupta, Tulika Tripathi, Priyank Rai.
J Family Med Prim Care, 2020 Oct 29; 9(8). PMID: 33110782    Free PMC article.
Review.
Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome.
Dustin L Norton, Agathe Ceppe, +9 authors, Jason R Mock.
J Transl Med, 2020 Nov 13; 18(1). PMID: 33176790    Free PMC article.
Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls.
Masayuki Hashimoto, Dongming Sun, +2 authors, Wise Young.
J Neurosci, 2007 Mar 30; 27(13). PMID: 17392476    Free PMC article.
Osteopontin - a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease.
Bogdan-Ioan Coculescu, Gheorghe Manole, +3 authors, Cristina Mariana Stocheci.
J Enzyme Inhib Med Chem, 2019 Mar 08; 34(1). PMID: 30843743    Free PMC article.
The Significance of Secreted Phosphoprotein 1 in Multiple Human Cancers.
Tengteng Wei, Guoshu Bi, +9 authors, Donglin Zhu.
Front Mol Biosci, 2020 Dec 17; 7. PMID: 33324676    Free PMC article.
Expression of Extracellular Matrix-Related Genes and Their Regulatory microRNAs in Problematic Colorectal Polyps.
Margareta Žlajpah, Emanuela Boštjančič, Bojan Tepeš, Nina Zidar.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322258    Free PMC article.
The Roles of Osteopontin in the Pathogenesis of West Nile Encephalitis.
Farzana Nazneen, Fengwei Bai.
Vaccines (Basel), 2020 Dec 16; 8(4). PMID: 33317005    Free PMC article.
Review.
Effects of Neurological Disorders on Bone Health.
Ryan R Kelly, Sara J Sidles, Amanda C LaRue.
Front Psychol, 2021 Jan 12; 11. PMID: 33424724    Free PMC article.
Review.
Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis.
James G Tidball, Ivan Flores, +2 authors, Eisuke Ochi.
Exp Gerontol, 2020 Dec 29; 145. PMID: 33359378    Free PMC article.
Review.
Identification of Key Candidate Genes Involved in the Progression of Idiopathic Pulmonary Fibrosis.
Yu Cui, Jie Ji, +2 authors, Xiaodong Han.
Molecules, 2021 Mar 07; 26(4). PMID: 33672678    Free PMC article.
Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix.
Marta S Carvalho, Joaquim M S Cabral, Cláudia L da Silva, Deepak Vashishth.
Polymers (Basel), 2021 Apr 04; 13(7). PMID: 33808184    Free PMC article.
Review.
Osteopontin and osteoprotegerin in atherosclerotic plaque - are they significant markers of plaque vulnerability?
Cristina Strobescu-Ciobanu, Simona Eliza Giuşcă, +5 authors, Cristian Dumitru Lupaşcu.
Rom J Morphol Embryol, 2021 Apr 06; 61(3). PMID: 33817720    Free PMC article.
The multifaceted progenitor fates in healthy or unhealthy adipose tissue during obesity.
Geneviève Marcelin, Karine Clément.
Rev Endocr Metab Disord, 2021 Jun 10; 22(4). PMID: 34105090
Review.
Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma.
Masahiro Nishikawa, Akihiro Inoue, +12 authors, Takeharu Kunieda.
Transl Oncol, 2021 May 31; 14(8). PMID: 34052625    Free PMC article.
The Correlation Between SPP1 and Immune Escape of EGFR Mutant Lung Adenocarcinoma Was Explored by Bioinformatics Analysis.
Yi Zheng, Shiying Hao, +6 authors, Yan Zhang.
Front Oncol, 2021 Jun 29; 11. PMID: 34178613    Free PMC article.
Bone-Derived Modulators That Regulate Brain Function: Emerging Therapeutic Targets for Neurological Disorders.
Hongzhen Chen, Dewei Shang, Yuguan Wen, Chao Liang.
Front Cell Dev Biol, 2021 Jun 29; 9. PMID: 34179014    Free PMC article.
Review.
Molecular Biomarkers in Idiopathic Pulmonary Fibrosis: State of the Art and Future Directions.
Anna Stainer, Paola Faverio, +5 authors, Fabrizio Luppi.
Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34200784    Free PMC article.
Review.
Osteopontin in vitreous and idiopathic epiretinal membranes.
Lucia Dinice, Andrea Cacciamani, +5 authors, Alessandra Micera.
Graefes Arch Clin Exp Ophthalmol, 2020 Apr 12; 258(7). PMID: 32277255
Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging.
Michael Lekwuwa, Mayur Choudhary, Eleonora M Lad, Goldis Malek.
Mod Pathol, 2021 Aug 15; 35(2). PMID: 34389792    Free PMC article.
Binding Mode Characterization of Osteopontin on Hydroxyapatite by Solution NMR Spectroscopy.
Julian Holzinger, Harald Kotisch, Klaus W Richter, Robert Konrat.
Chembiochem, 2021 Apr 30; 22(13). PMID: 33914399    Free PMC article.
Modeling of the Human Bone Environment: Mechanical Stimuli Guide Mesenchymal Stem Cell-Extracellular Matrix Interactions.
Ana Rita Pereira, Andreas Lipphaus, +5 authors, Marietta Herrmann.
Materials (Basel), 2021 Aug 28; 14(16). PMID: 34442954    Free PMC article.
Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases.
Toshio Hattori, Hiroko Iwasaki-Hozumi, +6 authors, Takashi Matsuba.
Biomedicines, 2021 Aug 28; 9(8). PMID: 34440210    Free PMC article.
Review.
Th17-Related Cytokines as Potential Discriminatory Markers between Neuromyelitis Optica (Devic's Disease) and Multiple Sclerosis-A Review.
Karina Maciak, Sylwia Pietrasik, +5 authors, Elzbieta Miller.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445668    Free PMC article.
Review.
Current Therapies for Neonatal Hypoxic-Ischaemic and Infection-Sensitised Hypoxic-Ischaemic Brain Damage.
Konstantina Tetorou, Claudia Sisa, +2 authors, Mariya Hristova.
Front Synaptic Neurosci, 2021 Sep 11; 13. PMID: 34504417    Free PMC article.
Review.
Histologic and molecular features in pathologic human menisci from knees with and without osteoarthritis.
Farrah A Monibi, Tania Pannellini, +2 authors, Scott A Rodeo.
J Orthop Res, 2021 Apr 02; 40(2). PMID: 33792974    Free PMC article.
CSF Levels of CXCL12 and Osteopontin as Early Markers of Primary Progressive Multiple Sclerosis.
Damiano Marastoni, Roberta Magliozzi, +6 authors, Massimiliano Calabrese.
Neurol Neuroimmunol Neuroinflamm, 2021 Oct 01; 8(6). PMID: 34588298    Free PMC article.
The Potential Role of Osteopontin in the Pathogenesis of Graves' Ophthalmopathy.
Heng Lou, Lian-Qun Wu, +2 authors, Jin-Wei Cheng.
Invest Ophthalmol Vis Sci, 2021 Sep 22; 62(12). PMID: 34546326    Free PMC article.
Osteopontin-derived synthetic peptide SVVYGLR upregulates functional regeneration of oral and maxillofacial soft-tissue injury.
Susumu Tanaka, Yoshinosuke Hamada, +2 authors, Mikihiko Kogo.
Jpn Dent Sci Rev, 2021 Oct 12; 57. PMID: 34630775    Free PMC article.
Review.
White matter injury but not germinal matrix hemorrhage induces elevated osteopontin expression in human preterm brains.
Gisela Nilsson, Ana A Baburamani, +5 authors, Xiaoyang Wang.
Acta Neuropathol Commun, 2021 Oct 17; 9(1). PMID: 34654477    Free PMC article.
Differential proteome profile, biological pathways, and network relationships of osteogenic proteins in calcified human aortic valves.
Richard I Han, Chenyue W Hu, +8 authors, K Jane Grande-Allen.
Heart Vessels, 2021 Nov 03; 37(2). PMID: 34727208
Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages.
Supriya Murthy, Isabel Karkossa, +8 authors, Manuela Rossol.
Cell Death Dis, 2022 Jan 14; 13(1). PMID: 35022393    Free PMC article.
Osteopontin is a biomarker for early autoimmune uveoretinitis.
Jeongtae Kim, Meejung Ahn, +5 authors, Taekyun Shin.
Neural Regen Res, 2021 Dec 18; 17(7). PMID: 34916447    Free PMC article.
Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration.
Sanako Makishi, Tomohiko Yamazaki, Hayato Ohshima.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35162963    Free PMC article.
Osteopontin in autoimmune disorders: current knowledge and future perspective.
Canhua Xu, Yaohong Wu, Ning Liu.
Inflammopharmacology, 2022 Mar 03; 30(2). PMID: 35235108
Review.
Update on Multiple Sclerosis Molecular Biomarkers to Monitor Treatment Effects.
Viviana Nociti, Marina Romozzi, Massimiliano Mirabella.
J Pers Med, 2022 Apr 24; 12(4). PMID: 35455665    Free PMC article.
Review.
Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence.
Sarah Rose Anderson, Jacqueline M Roberts, +5 authors, Monica L Vetter.
Elife, 2022 Apr 29; 11. PMID: 35481836    Free PMC article.