Review
. 2001 Jul;93(13).
doi: 10.1093/jnci/93.13.979.

National Institutes of Health Consensus Development Conference Statement: adjuvant therapy for breast cancer, November 1-3, 2000

P Eifel 1 J A Axelson  J Costa  J Crowley  W J Curran  A Deshler  S Fulton  C B Hendricks  M Kemeny  A B Kornblith  T A Louis  M Markman  R Mayer  D Roter  
Affiliations
  • PMID: 11438563
  •     149 citations

Abstract

Objective: Our goal was to provide health-care providers, patients, and the general public with an assessment of currently available data regarding the use of adjuvant therapy for breast cancer.

Participants: The participants included a non-Federal, non-advocate, 14-member panel representing the fields of oncology, radiology, surgery, pathology, statistics, public health, and health policy as well as patient representatives. In addition, 30 experts in medical oncology, radiation oncology, biostatistics, epidemiology, surgical oncology, and clinical trials presented data to the panel and to a conference audience of 1000.

Evidence: The literature was searched with the use of MEDLINE(TM) for January 1995 through July 2000, and an extensive bibliography of 2230 references was provided to the panel. Experts prepared abstracts for their conference presentations with relevant citations from the literature. Evidence from randomized clinical trials and evidence from prospective studies were given precedence over clinical anecdotal experience.

Consensus Process: The panel, answering predefined questions, developed its conclusions based on the evidence presented in open forum and the scientific literature. The panel composed a draft statement, which was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after the conference. The draft statement was made available on the World Wide Web immediately after its release at the conference and was updated with the panel's final revisions. The statement is available at http://consensus.nih.gov.

Conclusions: The panel concludes that decisions regarding adjuvant hormonal therapy should be based on the presence of hormone receptor protein in tumor tissues. Adjuvant hormonal therapy should be offered only to women whose tumors express hormone receptor protein. Because adjuvant polychemotherapy improves survival, it should be recommended to the majority of women with localized breast cancer regardless of lymph node, menopausal, or hormone receptor status. The inclusion of anthracyclines in adjuvant chemotherapy regimens produces a small but statistically significant improvement in survival over non-anthracycline-containing regimens. Available data are currently inconclusive regarding the use of taxanes in adjuvant treatment of lymph node-positive breast cancer. The use of adjuvant dose-intensive chemotherapy regimens in high-risk breast cancer and of taxanes in lymph node-negative breast cancer should be restricted to randomized trials. Ongoing studies evaluating these treatment strategies should be supported to determine if such strategies have a role in adjuvant treatment. Studies to date have included few patients older than 70 years. There is a critical need for trials to evaluate the role of adjuvant chemotherapy in these women. There is evidence that women with a high risk of locoregional tumor recurrence after mastectomy benefit from postoperative radiotherapy. This high-risk group includes women with four or more positive lymph nodes or an advanced primary cancer. Currently, the role of postmastectomy radiotherapy for patients with one to three positive lymph nodes remains uncertain and should be tested in a randomized controlled trial. Individual patients differ in the importance they place on the risks and benefits of adjuvant treatments. Quality of life needs to be evaluated in selected randomized clinical trials to examine the impact of the major acute and long-term side effects of adjuvant treatments, particularly premature menopause, weight gain, mild memory loss, and fatigue. Methods to support shared decision-making between patients and their physicians have been successful in trials; they need to be tailored for diverse populations and should be tested for broader dissemination.

What is the ideal duration of adjuvant therapy for primary breast cancer: are four cycles of cyclophosphamide and doxorubicin enough?
L N Shulman.
Curr Oncol Rep, 2001 Oct 12; 3(6). PMID: 11595121
Review.
Predictors of long-term outcome following high-dose chemotherapy in high-risk primary breast cancer.
G Somlo, J F Simpson, +12 authors, J H Doroshow.
Br J Cancer, 2002 Aug 15; 87(3). PMID: 12177795    Free PMC article.
Population-based assessment of hospitalizations for toxicity from chemotherapy in older women with breast cancer.
Xianglin L Du, Cynthia Osborne, James S Goodwin.
J Clin Oncol, 2002 Dec 19; 20(24). PMID: 12488407    Free PMC article.
Discrepancy between consensus recommendations and actual community use of adjuvant chemotherapy in women with breast cancer.
Xianglin L Du, Charles R Key, +2 authors, James S Goodwin.
Ann Intern Med, 2003 Jan 17; 138(2). PMID: 12529090    Free PMC article.
Survival of lymph node-negative breast cancer patients in relation to number of lymph nodes examined.
Anthony P Polednak.
Ann Surg, 2003 Feb 01; 237(2). PMID: 12560772    Free PMC article.
Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer.
Samuel W Beenken, Marshall M Urist, +4 authors, Kirby I Bland.
Ann Surg, 2003 May 02; 237(5). PMID: 12724640    Free PMC article.
Activity of first-line epirubicin and paclitaxel in metastatic breast cancer is independent of type of adjuvant therapy.
A Gennari, P Bruzzi, +7 authors, P Conte.
Br J Cancer, 2004 Mar 05; 90(5). PMID: 14997190    Free PMC article.
Molecular profiling of breast cancer: clinical implications.
S Cleator, A Ashworth.
Br J Cancer, 2004 Mar 18; 90(6). PMID: 15026788    Free PMC article.
Review.
Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy.
Pauline T Truong, Ivo A Olivotto, +2 authors, Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer.
CMAJ, 2004 Apr 14; 170(8). PMID: 15078851    Free PMC article.
Prognostic molecular markers in early breast cancer.
Francisco J Esteva, Gabriel N Hortobagyi.
Breast Cancer Res, 2004 Apr 16; 6(3). PMID: 15084231    Free PMC article.
Review.
Biomolecular features of clinical relevance in breast cancer.
Maria Grazia Daidone, Angelo Paradiso, +3 authors, Manfred Schmitt.
Eur J Nucl Med Mol Imaging, 2004 Apr 20; 31 Suppl 1. PMID: 15095022
Review.
A prognostic index for operable, node-negative breast cancer.
M McCallum, C Baker, +10 authors, M Steel.
Br J Cancer, 2004 May 13; 90(10). PMID: 15138474    Free PMC article.
Community-based assessment of adjuvant hormone therapy in women with breast cancer, 1991-1997.
Xianglin L Du, Charles R Key, Cynthia Osborne.
Breast J, 2004 Aug 26; 10(5). PMID: 15327498    Free PMC article.
Genomic and proteomic approaches for studying human cancer: prospects for true patient-tailored therapy.
Kristen M Carr, Kevin Rosenblatt, Emanuel F Petricoin, Lance A Liotta.
Hum Genomics, 2004 Dec 17; 1(2). PMID: 15601541    Free PMC article.
Review.
30 years' follow up of randomised studies of adjuvant CMF in operable breast cancer: cohort study.
Gianni Bonadonna, Angela Moliterni, +4 authors, Pinuccia Valagussa.
BMJ, 2005 Jan 15; 330(7485). PMID: 15649903    Free PMC article.
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
Howard Y Chang, Dimitry S A Nuyten, +10 authors, Marc J van de Vijver.
Proc Natl Acad Sci U S A, 2005 Feb 11; 102(10). PMID: 15701700    Free PMC article.
Highly Cited.
Utilizing prognostic and predictive factors in breast cancer.
Deepa S Subramaniam, Claudine Isaacs.
Curr Treat Options Oncol, 2005 Feb 19; 6(2). PMID: 15717996
Review.
Compliance and toxicity of adjuvant CMF in elderly breast cancer patients: a single-center experience.
Ermelinda De Maio, Adriano Gravina, +13 authors, Andrea de Matteis.
BMC Cancer, 2005 Mar 26; 5. PMID: 15790416    Free PMC article.
Predictors and outcomes of surgeons' referral of older breast cancer patients to medical oncologists.
Soe Soe Thwin, Aliza K Fink, Timothy L Lash, Rebecca A Silliman.
Cancer, 2005 Jun 30; 104(5). PMID: 15986400    Free PMC article.
Population-based study of the relationship of treatment and sociodemographics on quality of life for early stage breast cancer.
Nancy K Janz, Mahasin Mujahid, +5 authors, Steven J Katz.
Qual Life Res, 2005 Aug 23; 14(6). PMID: 16110927
Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance.
Pawel Surowiak, Verena Materna, +8 authors, Hermann Lage.
Breast Cancer Res, 2005 Sep 20; 7(5). PMID: 16168133    Free PMC article.
Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.
D Nikolić-Vukosavljević, M Markićević, +3 authors, Z Nesković-Konstantinović.
Clin Exp Metastasis, 2005 Sep 20; 22(4). PMID: 16170672
Effectiveness of adjuvant chemotherapy for node-positive operable breast cancer in older women.
Xianglin L Du, Dennie V Jones, Dong Zhang.
J Gerontol A Biol Sci Med Sci, 2005 Sep 27; 60(9). PMID: 16183952    Free PMC article.
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts.
Yudi Pawitan, Judith Bjöhle, +17 authors, Jonas Bergh.
Breast Cancer Res, 2005 Nov 11; 7(6). PMID: 16280042    Free PMC article.
Highly Cited.
Adjuvant chemotherapy for non-small cell lung cancer.
Edward J Crane, George Simon.
Curr Treat Options Oncol, 2005 Dec 14; 7(1). PMID: 16343368
Review.
Goserelin: a review of its use in the treatment of early breast cancer in premenopausal and perimenopausal women.
Susan M Cheer, Greg L Plosker, Dene Simpson, Antona J Wagstaff.
Drugs, 2006 Jan 06; 65(18). PMID: 16392882
Review.
The impact of expression profiling on prognostic and predictive testing in breast cancer.
J S Reis-Filho, C Westbury, J-Y Pierga.
J Clin Pathol, 2006 Mar 01; 59(3). PMID: 16505270    Free PMC article.
Review.
A systems approach to clinical oncology: focus on breast cancer.
Mark Abramovitz, Brian Leyland-Jones.
Proteome Sci, 2006 Apr 06; 4. PMID: 16595007    Free PMC article.
A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients.
Laurel A Habel, Steven Shak, +12 authors, Charles P Quesenberry.
Breast Cancer Res, 2006 Jun 02; 8(3). PMID: 16737553    Free PMC article.
Highly Cited.
Improved breast cancer prognosis through the combination of clinical and genetic markers.
Yijun Sun, Steve Goodison, +2 authors, William Farmerie.
Bioinformatics, 2006 Nov 30; 23(1). PMID: 17130137    Free PMC article.
Survivin is an independent predictor of short-term survival in poor prognostic breast cancer patients.
A R Hinnis, J C A Luckett, R A Walker.
Br J Cancer, 2007 Feb 08; 96(4). PMID: 17285125    Free PMC article.
Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients.
E de Azambuja, F Cardoso, +7 authors, M Paesmans.
Br J Cancer, 2007 Apr 25; 96(10). PMID: 17453008    Free PMC article.
Highly Cited.
Molecular profiling in breast cancer.
Shannon R Morris, Lisa A Carey.
Rev Endocr Metab Disord, 2007 Apr 28; 8(3). PMID: 17464566
Review.
Amplification patterns of three genomic regions predict distant recurrence in breast carcinoma.
Lisa M Davis, Cole Harris, +10 authors, John Hozier.
J Mol Diagn, 2007 Jun 27; 9(3). PMID: 17591932    Free PMC article.
Effect of postmastectomy radiotherapy in patients <35 years old with stage II-III breast cancer treated with doxorubicin-based neoadjuvant chemotherapy and mastectomy.
Amit K Garg, Julia L Oh, +9 authors, Thomas A Buchholz.
Int J Radiat Oncol Biol Phys, 2007 Sep 15; 69(5). PMID: 17855016    Free PMC article.
Use of the Oncotype DX 21-gene assay to guide adjuvant decision making in early-stage breast cancer.
Alison K Conlin, Andrew D Seidman.
Mol Diagn Ther, 2007 Dec 15; 11(6). PMID: 18078353
Review.
Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study.
Simon J Crabb, Chris D Bajdik, +4 authors, Karen A Gelmon.
Breast Cancer Res, 2008 Jan 16; 10(1). PMID: 18194560    Free PMC article.
Merging microarray data from separate breast cancer studies provides a robust prognostic test.
Lei Xu, Aik Choon Tan, Raimond L Winslow, Donald Geman.
BMC Bioinformatics, 2008 Feb 29; 9. PMID: 18304324    Free PMC article.
Competing causes of death for women with breast cancer and change over time from 1975 to 2003.
Xianglin L Du, Erin E Fox, Dejian Lai.
Am J Clin Oncol, 2008 Apr 09; 31(2). PMID: 18391593    Free PMC article.
Sequencing chemotherapy and radiotherapy in locoregional advanced breast cancer patients after mastectomy - a retrospective analysis.
Marc D Piroth, Michael Pinkawa, +3 authors, Michael J Eble.
BMC Cancer, 2008 Apr 25; 8. PMID: 18433485    Free PMC article.
Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort.
Ben S Wittner, Dennis C Sgroi, +9 authors, Sridhar Ramaswamy.
Clin Cancer Res, 2008 May 17; 14(10). PMID: 18483364    Free PMC article.
Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer.
Grace M Callagy, Mark J Webber, Paul D P Pharoah, Carlos Caldas.
BMC Cancer, 2008 May 31; 8. PMID: 18510726    Free PMC article.
Review.
A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all?
B Haibe-Kains, C Desmedt, C Sotiriou, G Bontempi.
Bioinformatics, 2008 Jul 19; 24(19). PMID: 18635567    Free PMC article.
Comparison of prognostic gene expression signatures for breast cancer.
Benjamin Haibe-Kains, Christine Desmedt, +6 authors, Christos Sotiriou.
BMC Genomics, 2008 Aug 23; 9. PMID: 18717985    Free PMC article.
Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.
M W Helms, D Kemming, +8 authors, B H Brandt.
Br J Cancer, 2008 Aug 30; 99(5). PMID: 18728668    Free PMC article.
A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer.
Fabien Reyal, Martin H van Vliet, +10 authors, Lodewyk F A Wessels.
Breast Cancer Res, 2008 Nov 19; 10(6). PMID: 19014521    Free PMC article.
The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome.
Jens K Habermann, Jana Doering, +12 authors, Thomas Ried.
Int J Cancer, 2008 Dec 23; 124(7). PMID: 19101988    Free PMC article.
Postmastectomy radiotherapy for breast cancer: patterns, correlates, communication, and insights into the decision process.
Reshma Jagsi, Paul Abrahamse, +3 authors, Steven J Katz.
Cancer, 2009 Jan 31; 115(6). PMID: 19180636    Free PMC article.
[Genome-wide expression profiling as a clinical tool: are we there yet?].
F C Geyer, T Decker, J S Reis-Filho.
Pathologe, 2009 Feb 17; 30(2). PMID: 19219435
Review.
A radiation-derived gene expression signature predicts clinical outcome for breast cancer patients.
Brian D Piening, Pei Wang, Aravind Subramanian, Amanda G Paulovich.
Radiat Res, 2009 Mar 10; 171(2). PMID: 19267539    Free PMC article.
Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling.
Yaqin Zhang, Leslie A Rivera Rosado, Sun Young Moon, Baolin Zhang.
J Biol Chem, 2009 Mar 10; 284(19). PMID: 19269969    Free PMC article.
Patterns of treatment for early stage breast cancers at the M. D. Anderson Cancer Center from 1997 to 2004.
Yu Shen, Wenli Dong, +3 authors, Sharon H Giordano.
Cancer, 2009 Mar 17; 115(10). PMID: 19288569    Free PMC article.
Recent advances in systemic therapy: new diagnostics and biological predictors of outcome in early breast cancer.
Catherine Oakman, Silvia Bessi, +3 authors, Angelo Di Leo.
Breast Cancer Res, 2009 May 14; 11(2). PMID: 19435470    Free PMC article.
Review.
Current molecular diagnostics of breast cancer and the potential incorporation of microRNA.
Christine K Zoon, Elizabeth Q Starker, +3 authors, Michael A Tangrea.
Expert Rev Mol Diagn, 2009 Jul 08; 9(5). PMID: 19580430    Free PMC article.
Review.
Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer.
Steven Buechler.
BMC Cancer, 2009 Jul 22; 9. PMID: 19619298    Free PMC article.
Involving patients in cardiovascular risk management with nurse-led clinics: a cluster randomized controlled trial.
Marije S Koelewijn-van Loon, Trudy van der Weijden, +6 authors, Richard Grol.
CMAJ, 2009 Dec 02; 181(12). PMID: 19948811    Free PMC article.
Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a phase 3, open-label, randomised controlled trial.
Kathy S Albain, William E Barlow, +18 authors, Breast Cancer Intergroup of North America.
Lancet, 2009 Dec 17; 374(9707). PMID: 20004966    Free PMC article.
A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors.
Bastiaan Evers, Eva Schut, +8 authors, Jos Jonkers.
Clin Cancer Res, 2009 Dec 17; 16(1). PMID: 20008842    Free PMC article.
Role of axillary clearance after a tumor-positive sentinel node in the administration of adjuvant therapy in early breast cancer.
Marieke E Straver, Philip Meijnen, +11 authors, Emiel J T Rutgers.
J Clin Oncol, 2009 Dec 30; 28(5). PMID: 20038733    Free PMC article.
Search for the smallest random forest.
Heping Zhang, Minghui Wang.
Stat Interface, 2010 Feb 19; 2(3). PMID: 20165560    Free PMC article.
Oncology care in rural northern new England.
Ali Johnson, Judy R Rees, +10 authors, Johannes C Nunnink.
J Oncol Pract, 2010 Jul 02; 6(2). PMID: 20592781    Free PMC article.
Disparities in the use of radiation therapy in patients with local-regionally advanced breast cancer.
Steve R Martinez, Shannon H Beal, +4 authors, Richard J Bold.
Int J Radiat Oncol Biol Phys, 2010 Jul 14; 78(3). PMID: 20619550    Free PMC article.
Perspectives on Breast Cancer Management: Tailoring Treatment to the Individual Patient.
Christoph Thomssen.
Breast Care (Basel), 2008 Jan 01; 3(s1). PMID: 20824005    Free PMC article.
Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice.
Claudia Raja Gabaglia, Alexandra DeLaney, +5 authors, Todd A Braciak.
J Transl Med, 2010 Oct 16; 8. PMID: 20946663    Free PMC article.
Local outcomes in ductal carcinoma in situ based on patient and tumor characteristics.
Stuart J Schnitt.
J Natl Cancer Inst Monogr, 2010 Oct 20; 2010(41). PMID: 20956823    Free PMC article.
Review.
Derivation of cancer diagnostic and prognostic signatures from gene expression data.
Steve Goodison, Yijun Sun, Virginia Urquidi.
Bioanalysis, 2010 Nov 19; 2(5). PMID: 21083217    Free PMC article.
Review.
Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas?
Mathew Purdom, Michael L Cibull, +4 authors, Rouzan G Karabakhtsian.
Patholog Res Int, 2010 Dec 15; 2011. PMID: 21151541    Free PMC article.
Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer.
Song Yao, William E Barlow, +15 authors, Christine B Ambrosone.
Clin Cancer Res, 2010 Dec 21; 16(24). PMID: 21169260    Free PMC article.
Physical and psychosocial recovery in the year after primary treatment of breast cancer.
Patricia A Ganz, Lorna Kwan, +2 authors, Thomas R Belin.
J Clin Oncol, 2011 Feb 09; 29(9). PMID: 21300931    Free PMC article.
Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: is there a role for radiation therapy?
Rusen Cosar, Cem Uzal, +10 authors, Zafer Kocak.
Radiat Oncol, 2011 Apr 01; 6. PMID: 21450076    Free PMC article.
Gene expression profile testing for breast cancer and the use of chemotherapy, serious adverse effects, and costs of care.
Jennifer S Haas, Su-Ying Liang, +3 authors, Kathryn A Phillips.
Breast Cancer Res Treat, 2011 Jun 18; 130(2). PMID: 21681446    Free PMC article.
Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases.
Anders Carlsson, Christer Wingren, +10 authors, Carl A K Borrebaeck.
Proc Natl Acad Sci U S A, 2011 Aug 17; 108(34). PMID: 21844363    Free PMC article.
Genomic testing and therapies for breast cancer in clinical practice.
Jennifer S Haas, Kathryn A Phillips, +5 authors, Michele Toscano.
J Oncol Pract, 2011 Sep 03; 7(3 Suppl). PMID: 21886507    Free PMC article.
Colorectal cancer cell surface protein profiling using an antibody microarray and fluorescence multiplexing.
Jerry Zhou, Larissa Belov, +3 authors, Richard I Christopherson.
J Vis Exp, 2011 Oct 05; (55). PMID: 21968569    Free PMC article.
Apoptosis - associated genes and their role in predicting responses to neoadjuvant breast cancer treatment.
Daniel Tvrdík, Helena Skálová, +5 authors, Luboš Petruželka.
Med Sci Monit, 2011 Dec 31; 18(1). PMID: 22207111    Free PMC article.
Post-genomic clinical trials: the perspective of ACGT.
N Graf, C Desmedt, +6 authors, M Tsiknakis.
Ecancermedicalscience, 2008 Jan 01; 2. PMID: 22275963    Free PMC article.
Differential gene expression in primary breast tumors associated with lymph node metastasis.
Rachel E Ellsworth, Lori A Field, +3 authors, Craig D Shriver.
Int J Breast Cancer, 2012 Feb 02; 2011. PMID: 22295210    Free PMC article.
Patients with positive axillary lymph nodes: how to use genomic assays.
Ruta Rao.
Curr Treat Options Oncol, 2012 Mar 20; 13(2). PMID: 22426945
Active roles of tumor stroma in breast cancer metastasis.
Zahraa I Khamis, Ziad J Sahab, Qing-Xiang Amy Sang.
Int J Breast Cancer, 2012 Apr 07; 2012. PMID: 22482059    Free PMC article.
Should Postmastectomy Radiotherapy to the Chest Wall and Regional Lymph Nodes Be Standard for Patients with 1-3 Positive Lymph Nodes?
Birgitte V Offersen, Hans-Jürgen Brodersen, +2 authors, Marie Overgaard.
Breast Care (Basel), 2012 May 24; 6(5). PMID: 22619643    Free PMC article.
Estrogen Receptor Negative Breast Cancer in India: Do We Really Have Higher Burden of this Subtype?
Suraj Manjunath, Jyothi S Prabhu, +2 authors, T S Sridhar.
Indian J Surg Oncol, 2012 Jun 14; 2(2). PMID: 22693404    Free PMC article.
Pathway-based classification of cancer subtypes.
Shinuk Kim, Mark Kon, Charles DeLisi.
Biol Direct, 2012 Jul 05; 7. PMID: 22759382    Free PMC article.
The prognostic value of lymph node cross-sectional cancer area in node-positive breast cancer: a comparison with N stage and lymph node ratio.
Yanxia Li, Earle Holmes, +3 authors, Cağatay Erşahin.
Patholog Res Int, 2012 Oct 25; 2012. PMID: 23094198    Free PMC article.
Prediction and prognosis: impact of gene expression profiling in personalized treatment of breast cancer patients.
Michael R Mallmann, Andrea Staratschek-Jox, +5 authors, Joachim L Schultze.
EPMA J, 2010 Sep 01; 1(3). PMID: 23199086    Free PMC article.
Sequential docetaxel as adjuvant chemotherapy for node-positive or/and T3 or T4 breast cancer: clinical outcome (Mansoura University).
H Sakr, R H Hamed, A H Anter, T Yossef.
Med Oncol, 2013 Jan 17; 30(1). PMID: 23322524
Breast cancer subtypes: response to radiotherapy and potential radiosensitisation.
F E Langlands, K Horgan, D D Dodwell, L Smith.
Br J Radiol, 2013 Feb 09; 86(1023). PMID: 23392193    Free PMC article.
Review.
HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease.
Laurel A Habel, Lori C Sakoda, +6 authors, Charles P Quesenberry.
Breast Cancer Res, 2013 Mar 19; 15(2). PMID: 23497539    Free PMC article.
Gene expression profiling of breast cancer survivability by pooled cDNA microarray analysis using logistic regression, artificial neural networks and decision trees.
Hsiu-Ling Chou, Chung-Tay Yao, +10 authors, Chi-Ming Chu.
BMC Bioinformatics, 2013 Mar 20; 14. PMID: 23506640    Free PMC article.
Long-term prognostic performance of Ki67 rate in early stage, pT1-pT2, pN0, invasive breast carcinoma.
Fabien Reyal, David Hajage, +14 authors, Xavier Sastre-Garau.
PLoS One, 2013 Mar 26; 8(3). PMID: 23526930    Free PMC article.
Evaluating use characteristics for the oncotype dx 21-gene recurrence score and concordance with chemotherapy use in early-stage breast cancer.
Clara Chen, Rahul Dhanda, +2 authors, Debra A Patt.
J Oncol Pract, 2013 Aug 15; 9(4). PMID: 23942918    Free PMC article.
Axillary dissection can be avoided in the majority of clinically node-negative patients undergoing breast-conserving therapy.
Lynn T Dengel, Kimberly J Van Zee, +12 authors, Monica Morrow.
Ann Surg Oncol, 2013 Aug 27; 21(1). PMID: 23975314    Free PMC article.
Low-dose-area-constrained helical TomoTherapy-based whole breast radiotherapy and dosimetric comparison with tangential field-in-field IMRT.
Jie Qiu, Zhikai Liu, +2 authors, Fuquan Zhang.
Biomed Res Int, 2013 Sep 12; 2013. PMID: 24024197    Free PMC article.
Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer.
Yasutomo Sekido, Masaya Mukai, +6 authors, Naoya Nakamura.
Oncol Lett, 2013 Dec 19; 7(1). PMID: 24348820    Free PMC article.
Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer.
Ning Qing Liu, Christoph Stingl, +15 authors, Arzu Umar.
J Natl Cancer Inst, 2014 Jan 09; 106(2). PMID: 24399849    Free PMC article.
Pathologic and clinical characteristics of elderly patients with breast cancer: a retrospective analysis of a multicenter study (Anatolian Society of Medical Oncology).
Ali Inal, Tulay Akman, +19 authors, Abdurrahman Isıkdogan.
Int Surg, 2014 Jan 22; 99(1). PMID: 24444261    Free PMC article.
Oncological safety of immediate rectus abdominis myocutaneous breast reconstruction in patients with locally advanced disease (stage IIb and III).
Mushtaq Mir, Muddassir Shahdhar, Khurshid Ganaie, Quibtiya Syed.
South Asian J Cancer, 2014 Jan 24; 2(4). PMID: 24455647    Free PMC article.
Risk of lymphedema after mastectomy: potential benefit of applying ACOSOG Z0011 protocol to mastectomy patients.
Cynthia L Miller, Michelle C Specht, +7 authors, Alphonse G Taghian.
Breast Cancer Res Treat, 2014 Feb 07; 144(1). PMID: 24500108    Free PMC article.
Use of hormonal therapy in senior breast cancer patients treated with or without radiotherapy.
S P Krotneva, A Ramjaun, +5 authors, A N Meguerditchian.
Curr Oncol, 2014 Feb 14; 21(1). PMID: 24523607    Free PMC article.
CCNA2 is a prognostic biomarker for ER+ breast cancer and tamoxifen resistance.
Tian Gao, Yong Han, +3 authors, Jiafu Ji.
PLoS One, 2014 Mar 14; 9(3). PMID: 24622579    Free PMC article.
Spectrum of very early breast cancer in a setting without organised screening.
N Bhoo-Pathy, S Subramaniam, +6 authors, H M Verkooijen.
Br J Cancer, 2014 Apr 17; 110(9). PMID: 24736587    Free PMC article.
Second malignancies after breast cancer: The impact of adjuvant therapy.
Chunhui Dong, Ling Chen.
Mol Clin Oncol, 2014 Apr 29; 2(3). PMID: 24772296    Free PMC article.
Review.
Axillary lymph node clearance in patients with positive sentinel lymph node biopsy.
T Hussain, P J Kneeshaw.
Ann R Coll Surg Engl, 2014 May 02; 96(3). PMID: 24780783    Free PMC article.
Cost-utility analysis of chemotherapy regimens in elderly patients with stage III colon cancer.
David R Lairson, Rohan C Parikh, +2 authors, Xianglin L Du.
Pharmacoeconomics, 2014 Jun 13; 32(10). PMID: 24920195
Breast cancer prognosis risk estimation using integrated gene expression and clinical data.
Ashish Saini, Jingyu Hou, Wanlei Zhou.
Biomed Res Int, 2014 Jun 21; 2014. PMID: 24949450    Free PMC article.
Membranous Nectin-4 expression is a risk factor for distant relapse of T1-T2, N0 luminal-A early breast cancer.
R Lattanzio, R Ghasemi, +7 authors, M Piantelli.
Oncogenesis, 2014 Sep 02; 3. PMID: 25178039    Free PMC article.
99mTc-3P4-RGD2 scintimammography in the assessment of breast lesions: comparative study with 99mTc-MIBI.
Qingjie Ma, Bin Chen, +6 authors, Lin Liu.
PLoS One, 2014 Sep 25; 9(9). PMID: 25250628    Free PMC article.
Variations in Guideline-Concordant Breast Cancer Adjuvant Therapy in Rural Georgia.
Gery P Guy, Joseph Lipscomb, +3 authors, Kevin C Ward.
Health Serv Res, 2014 Dec 11; 50(4). PMID: 25491350    Free PMC article.
Adjuvant ovarian suppression in premenopausal breast cancer.
Prudence A Francis, Meredith M Regan, +28 authors, International Breast Cancer Study Group.
N Engl J Med, 2014 Dec 17; 372(5). PMID: 25495490    Free PMC article.
Highly Cited.
The predictive accuracy of PREDICT: a personalized decision-making tool for Southeast Asian women with breast cancer.
Hoong-Seam Wong, Shridevi Subramaniam, +7 authors, Nirmala Bhoo-Pathy.
Medicine (Baltimore), 2015 Feb 26; 94(8). PMID: 25715267    Free PMC article.
Intraoperative radiotherapy in early stage breast cancer: potential indications and evidence to date.
G G Hanna, A M Kirby.
Br J Radiol, 2015 Mar 04; 88(1049). PMID: 25734489    Free PMC article.
Review.
Prognostic impact of chemotherapy-induced amenorrhea on premenopausal breast cancer: a meta-analysis of the literature.
Qiong Zhou, Wenjin Yin, +2 authors, Jingsong Lu.
Menopause, 2015 Mar 19; 22(10). PMID: 25783467    Free PMC article.
Review.
Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations.
Balazs I Bodai, Phillip Tuso.
Perm J, 2015 Apr 23; 19(2). PMID: 25902343    Free PMC article.
Review.
Racial/Ethnic and socioeconomic disparities in endocrine therapy adherence in breast cancer: a systematic review.
Megan C Roberts, Stephanie B Wheeler, Katherine Reeder-Hayes.
Am J Public Health, 2015 Apr 24; 105 Suppl 3. PMID: 25905855    Free PMC article.
Systematic Review.
Hormone receptor status (estrogen receptor, progesterone receptor), human epidermal growth factor-2 and p53 in South Indian breast cancer patients: A tertiary care center experience.
Rashmi Patnayak, Amitabh Jena, +4 authors, Mandyam Kumaraswamy Reddy.
Indian J Med Paediatr Oncol, 2015 Jul 15; 36(2). PMID: 26157289    Free PMC article.
Clinical Significance of Sentinel Node Positivity in Patients with Superficial Esophageal Cancer.
Hiroya Takeuchi, Hirofumi Kawakubo, +4 authors, Yuko Kitagawa.
World J Surg, 2015 Aug 25; 39(12). PMID: 26296842
Multiplexed detection of serological cancer markers with plasmon-enhanced Raman spectro-immunoassay.
Ming Li, Jeon Woong Kang, +2 authors, Ishan Barman.
Chem Sci, 2015 Sep 26; 6(7). PMID: 26405519    Free PMC article.
Identifying patients at high risk of breast cancer recurrence: strategies to improve patient outcomes.
Yehoda M Martei, Jennifer M Matro.
Breast Cancer (Dove Med Press), 2015 Oct 28; 7. PMID: 26504408    Free PMC article.
Review.
Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells.
Dinesh Vyas, Nicolas Lopez-Hisijos, +6 authors, Lakshmi S Chaturvedi.
J Nanosci Nanotechnol, 2015 Dec 23; 15(9). PMID: 26690867    Free PMC article.
STAT3-survivin signaling mediates a poor response to radiotherapy in HER2-positive breast cancers.
Jae-Sung Kim, Hyun-Ah Kim, +6 authors, Woo Chul Noh.
Oncotarget, 2016 Jan 13; 7(6). PMID: 26755645    Free PMC article.
Impact of Adjuvant Endocrine Therapy on Quality of Life and Symptoms: Observational Data Over 12 Months From the Mind-Body Study.
Patricia A Ganz, Laura Petersen, Julienne E Bower, Catherine M Crespi.
J Clin Oncol, 2016 Jan 21; 34(8). PMID: 26786934    Free PMC article.
21-Gene Recurrence Score Assay As a Predictor of Adjuvant Chemotherapy Administration for Early-Stage Breast Cancer: An Analysis of Use, Therapeutic Implications, and Disparity Profile.
Jagar Jasem, Arya Amini, +4 authors, Peter Kabos.
J Clin Oncol, 2016 Mar 24; 34(17). PMID: 27001563    Free PMC article.
Exploratory Cost-Effectiveness Analysis of Response-Guided Neoadjuvant Chemotherapy for Hormone Positive Breast Cancer Patients.
Anna Miquel-Cases, Valesca P Retèl, +3 authors, Wim H van Harten.
PLoS One, 2016 Apr 29; 11(4). PMID: 27124410    Free PMC article.
Increased Proportion of Variance Explained and Prediction Accuracy of Survival of Breast Cancer Patients with Use of Whole-Genome Multiomic Profiles.
Ana I Vazquez, Yogasudha Veturi, +4 authors, Gustavo de Los Campos.
Genetics, 2016 May 01; 203(3). PMID: 27129736    Free PMC article.
Visualization of basement membranes in normal breast and breast cancer tissues using multiphoton microscopy.
Xiufeng Wu, Gang Chen, +5 authors, Jun Yan.
Oncol Lett, 2016 Jun 18; 11(6). PMID: 27313695    Free PMC article.
Nanoparticles for imaging and treatment of metastatic breast cancer.
Qingxin Mu, Hui Wang, Miqin Zhang.
Expert Opin Drug Deliv, 2016 Jul 13; 14(1). PMID: 27401941    Free PMC article.
Review.
Interpretable per case weighted ensemble method for cancer associations.
Adrin Jalali, Nico Pfeifer.
BMC Genomics, 2016 Jul 21; 17. PMID: 27435615    Free PMC article.
Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues.
Xiujie Chen, Lei Liu, +7 authors, Hongbo Xie.
Oncotarget, 2016 Aug 27; 8(13). PMID: 27564264    Free PMC article.
Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.
Gabriele Corda, Gianluca Sala, +22 authors, Arturo Sala.
J Pathol, 2016 Nov 20; 241(3). PMID: 27859262    Free PMC article.
Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer.
Sayem Miah, Charles A S Banks, +3 authors, Michael P Washburn.
Mol Biosyst, 2016 Nov 29; 13(1). PMID: 27891540    Free PMC article.
Review.
Evaluation of the Quality of Adjuvant Endocrine Therapy Delivery for Breast Cancer Care in the United States.
Bobby Daly, Olufunmilayo I Olopade, +3 authors, Dezheng Huo.
JAMA Oncol, 2017 Feb 06; 3(7). PMID: 28152150    Free PMC article.
Using the 21-gene assay from core needle biopsies to choose neoadjuvant therapy for breast cancer: A multicenter trial.
Harry D Bear, Wen Wan, +8 authors, Amy P Sing.
J Surg Oncol, 2017 Apr 14; 115(8). PMID: 28407247    Free PMC article.
Traumatic Brain Injury and Neuropsychiatric Complications.
Saeed Ahmed, Hema Venigalla, +3 authors, Shahana Ayub.
Indian J Psychol Med, 2017 May 19; 39(2). PMID: 28515545    Free PMC article.
Review.
Spotlight on triptorelin in the treatment of premenopausal women with early-stage breast cancer.
Marta Venturelli, Giorgia Guaitoli, Claudia Omarini, Luca Moscetti.
Breast Cancer (Dove Med Press), 2018 Mar 20; 10. PMID: 29551913    Free PMC article.
Review.
Practice patterns and outcomes for patients with node-negative hormone receptor-positive breast cancer and intermediate 21-gene Recurrence Scores.
Jonathan Chen, Xian Wu, +2 authors, Himanshu Nagar.
Breast Cancer Res, 2018 Apr 18; 20(1). PMID: 29661221    Free PMC article.
Practical consensus recommendations regarding role of postmastectomy radiation therapy.
D Singh, G Saini, +8 authors, S Aggarwal.
South Asian J Cancer, 2018 May 04; 7(2). PMID: 29721470    Free PMC article.
Practical consensus recommendations on ovarian suppression in early breast cancer (adjuvant).
M Singhal, T P Sahoo, +8 authors, Purvish M Parikh.
South Asian J Cancer, 2018 May 04; 7(2). PMID: 29721484    Free PMC article.
Trends and outcomes of neoadjuvant radiotherapy compared with postoperative radiotherapy for malignant breast cancer.
Wenyan Fu, Hefen Sun, +5 authors, Wei Jin.
Oncotarget, 2018 Jun 01; 9(36). PMID: 29849958    Free PMC article.
Clinical relevance of the 21-gene Recurrence Score® assay in treatment decisions for patients with node-positive breast cancer in the genomic era.
Eleftherios P Mamounas, Christy A Russell, +2 authors, Kathy S Albain.
NPJ Breast Cancer, 2018 Aug 30; 4. PMID: 30155517    Free PMC article.
Review.
Investigating confounders of the association between survival and adjuvant radiation therapy after breast conserving surgery in a sample of elderly breast Cancer patients in Appalachia.
Fabian Camacho, Roger Anderson, Gretchen Kimmick.
BMC Cancer, 2019 Dec 19; 19(1). PMID: 31847855    Free PMC article.
Successful Immediate Staged Breast Reconstruction with Intermediary Autologous Lipotransfer in Irradiated Patients.
Kristina M Crawford, Denis Lawlor, +2 authors, Matthew R Endara.
Plast Reconstr Surg Glob Open, 2020 Jan 17; 7(9). PMID: 31942379    Free PMC article.
Evaluation of Prognosis in Hormone Receptor-Positive/HER2-Negative and Lymph Node-Negative Breast Cancer With Low Oncotype DX Recurrence Score.
Jane Meisel, Chao Zhang, +7 authors, Xiaoxian Li.
Clin Breast Cancer, 2018 Jan 07; 18(5). PMID: 29305309    Free PMC article.
A qualitative comparison of how older breast cancer survivors process treatment information regarding endocrine therapy.
Huibrie C Pieters, Emily Green, +2 authors, Annette L Stanton.
PLoS One, 2019 Feb 01; 14(1). PMID: 30703119    Free PMC article.
Differentially Expressed Genes in Matched Normal, Cancer, and Lymph Node Metastases Predict Clinical Outcomes in Patients With Breast Cancer.
Ga-Eon Kim, Nah Ihm Kim, +2 authors, Keunsoo Kang.
Appl Immunohistochem Mol Morphol, 2020 Feb 12; 28(2). PMID: 32044879    Free PMC article.
TP53 rs1042522 polymorphism and early-onset breast cancer.
Irmak Icen-Taskin, Sevgi Irtegun-Kandemir, Omer Munzuroglu.
J Res Med Sci, 2020 May 19; 25. PMID: 32419782    Free PMC article.
The healthcare value of the Magee Decision Algorithm™: use of Magee Equations™ and mitosis score to safely forgo molecular testing in breast cancer.
Rohit Bhargava, Beth Z Clark, +2 authors, David J Dabbs.
Mod Pathol, 2020 Mar 24; 33(8). PMID: 32203092    Free PMC article.
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China.
Haibo Wu, Wei Wang, +8 authors, Wenchu Lin.
Cancer Manag Res, 2019 Mar 14; 11. PMID: 30863158    Free PMC article.
Young-onset breast cancer: a poor prognosis only exists in low-risk patients.
Jianfei Fu, Lunpo Wu, +7 authors, Jinlin Du.
J Cancer, 2019 Jul 11; 10(14). PMID: 31289582    Free PMC article.
Cytological Grading of Breast Tumors-The Human and Canine Perspective.
Krithiga Kuppusamy, Aarathi Rajan, +3 authors, Priya Srinivas.
Front Vet Sci, 2019 Sep 12; 6. PMID: 31508437    Free PMC article.
Review.
PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes.
Rossano Lattanzio, Manuela Iezzi, +8 authors, Mauro Piantelli.
BMC Cancer, 2019 Aug 01; 19(1). PMID: 31362705    Free PMC article.