Journal Article
. 2001 Sep; 194(6):823-32.
doi: 10.1084/jem.194.6.823.

Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

R P Sutmuller 1 L M van Duivenvoorde  A van Elsas  T N Schumacher  M E Wildenberg  J P Allison  R E Toes  R Offringa  C J Melief  
  • PMID: 11560997
  •     40 References
  •     303 citations


Therapeutic efficacy of a tumor cell-based vaccine against experimental B16 melanoma requires the disruption of either of two immunoregulatory mechanisms that control autoreactive T cell responses: the cytotoxic T lymphocyte-associated antigen (CTLA)-4 pathway or the CD25(+) regulatory T (Treg) cells. Combination of CTLA-4 blockade and depletion of CD25(+) Treg cells results in maximal tumor rejection. Efficacy of the antitumor therapy correlates with the extent of autoimmune skin depigmentation as well as with the frequency of tyrosinase-related protein 2(180-188)-specific CTLs detected in the periphery. Furthermore, tumor rejection is dependent on the CD8(+) T cell subset. Our data demonstrate that the CTL response against melanoma antigens is an important component of the therapeutic antitumor response and that the reactivity of these CTLs can be augmented through interference with immunoregulatory mechanisms. The synergism in the effects of CTLA-4 blockade and depletion of CD25(+) Treg cells indicates that CD25(+) Treg cells and CTLA-4 signaling represent two alternative pathways for suppression of autoreactive T cell immunity. Simultaneous intervention with both regulatory mechanisms is therefore a promising concept for the induction of therapeutic antitumor immunity.

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J Immunol, 2007 Apr 20; 178(9). PMID: 17442923    Free PMC article.
Therapy of established B16-F10 melanoma tumors by a single vaccination of CTL/T helper peptides in VacciMax.
Marc Mansour, Bill Pohajdak, +5 authors, Pirouz Daftarian.
J Transl Med, 2007 Apr 25; 5. PMID: 17451606    Free PMC article.
Inability to mediate prolonged reduction of regulatory T Cells after transfer of autologous CD25-depleted PBMC and interleukin-2 after lymphodepleting chemotherapy.
Daniel J Powell, Christiaan R de Vries, +2 authors, Steven A Rosenberg.
J Immunother, 2007 Apr 26; 30(4). PMID: 17457218    Free PMC article.
Harnessing the immune system to treat cancer.
Nina Bhardwaj.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476342    Free PMC article.
Indoleamine 2,3-dioxygenase and tumor-induced tolerance.
David H Munn, Andrew L Mellor.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476344    Free PMC article.
Highly Cited. Review.
Tregs and rethinking cancer immunotherapy.
Tyler J Curiel.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476346    Free PMC article.
Highly Cited. Review.
Adoptive T cell therapy for cancer in the clinic.
Carl H June.
J Clin Invest, 2007 Jun 06; 117(6). PMID: 17549249    Free PMC article.
Highly Cited. Review.
The impact of regulatory T cells on carcinogen-induced sarcogenesis.
G Betts, J Twohig, +3 authors, A Gallimore.
Br J Cancer, 2007 Jun 15; 96(12). PMID: 17565340    Free PMC article.
Induction of postsurgical tumor immunity and T-cell memory by a poorly immunogenic tumor.
Peisheng Zhang, Anik L Côté, +2 authors, Mary Jo Turk.
Cancer Res, 2007 Jul 10; 67(13). PMID: 17616708    Free PMC article.
Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cells.
Adam T Hagymasi, Aaron M Slaiby, +4 authors, Adam J Adler.
J Immunol, 2007 Jul 21; 179(3). PMID: 17641018    Free PMC article.
CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion.
Anders E Pedersen, Franca Ronchese.
J Immune Based Ther Vaccines, 2007 Jul 31; 5. PMID: 17662155    Free PMC article.
Inhibitory costimulation and anti-tumor immunity.
Natalia Martin-Orozco, Chen Dong.
Semin Cancer Biol, 2007 Aug 09; 17(4). PMID: 17683946    Free PMC article.
Transplantation tolerance: lessons from experimental rodent models.
Cherry I Kingsley, Satish N Nadig, Kathryn J Wood.
Transpl Int, 2007 Aug 23; 20(10). PMID: 17711408    Free PMC article.
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.
Heather M Gibson, Carrie J Hedgcock, +4 authors, Henry K Wong.
J Immunol, 2007 Sep 06; 179(6). PMID: 17785820    Free PMC article.
Regulatory T cells and toll-like receptors: regulating the regulators.
Roger Sutmuller, Anja Garritsen, Gosse J Adema.
Ann Rheum Dis, 2007 Nov 21; 66 Suppl 3. PMID: 17934105    Free PMC article.
Resistance to apoptosis and expansion of regulatory T cells in relation to the detection of circulating tumor cells in patients with metastatic epithelial cancer.
Stefanie Stanzer, Nadia Dandachi, +3 authors, Thomas Bauernhofer.
J Clin Immunol, 2007 Oct 17; 28(2). PMID: 17939021
Increase of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+ CD25+ T lymphocytes.
S Audia, A Nicolas, +12 authors, B Bonnotte.
Clin Exp Immunol, 2007 Oct 25; 150(3). PMID: 17956583    Free PMC article.
Advancements in immune tolerance.
Ping-Ying Pan, Junko Ozao, Zuping Zhou, Shu-Hsia Chen.
Adv Drug Deliv Rev, 2007 Nov 03; 60(2). PMID: 17976856    Free PMC article.
Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction?
Stefan Löb, Alfred Königsrainer.
Langenbecks Arch Surg, 2007 Dec 08; 393(6). PMID: 18064486
Regulatory T cells and tumour immunity - observations in mice and men.
Awen Gallimore, Andrew Godkin.
Immunology, 2007 Dec 11; 123(2). PMID: 18067556    Free PMC article.
Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice.
Masanori Tsujie, Tomoko Tsujie, +4 authors, Ben K Seon.
Int J Cancer, 2008 Jan 29; 122(10). PMID: 18224682    Free PMC article.
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.
F Stephen Hodi, Marcus Butler, +17 authors, Glenn Dranoff.
Proc Natl Acad Sci U S A, 2008 Feb 22; 105(8). PMID: 18287062    Free PMC article.
Highly Cited.
Comparative methodologies of regulatory T cell depletion in a murine melanoma model.
Norimasa Matsushita, Shari A Pilon-Thomas, Lisa M Martin, Adam I Riker.
J Immunol Methods, 2008 Feb 26; 333(1-2). PMID: 18295790    Free PMC article.
A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression.
Xiao-Tong Song, Kevin Evel-Kabler, +3 authors, Si-Yi Chen.
Nat Med, 2008 Mar 04; 14(3). PMID: 18311150    Free PMC article.
Regulatory T cells and human disease.
Nathalie Cools, Peter Ponsaerts, Viggo F I Van Tendeloo, Zwi N Berneman.
Clin Dev Immunol, 2008 Mar 05; 2007. PMID: 18317534    Free PMC article.
Transient T cell depletion causes regression of melanoma metastases.
Mary Ann Rasku, Amy L Clem, +8 authors, Jason Chesney.
J Transl Med, 2008 Mar 13; 6. PMID: 18334033    Free PMC article.
Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma.
T Yoshioka, M Miyamoto, +13 authors, S Kondo.
Br J Cancer, 2008 Mar 20; 98(7). PMID: 18349839    Free PMC article.
Immunotherapy of malignant brain tumors.
Duane A Mitchell, Peter E Fecci, John H Sampson.
Immunol Rev, 2008 Mar 28; 222. PMID: 18363995    Free PMC article.
Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model.
Ana P Castano, Pawel Mroz, Mei X Wu, Michael R Hamblin.
Proc Natl Acad Sci U S A, 2008 Apr 02; 105(14). PMID: 18378905    Free PMC article.
Developing idiotype vaccines for lymphoma: from preclinical studies to phase III clinical trials.
Hyun Jun Park, Sattva S Neelapu.
Br J Haematol, 2008 Apr 22; 142(2). PMID: 18422783    Free PMC article.
Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials.
James F Curtin, Marianela Candolfi, +5 authors, Maria G Castro.
PLoS One, 2008 Apr 24; 3(4). PMID: 18431473    Free PMC article.
Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration.
Daniel J Powell, Peter Attia, +3 authors, Steven A Rosenberg.
J Immunother, 2008 May 16; 31(2). PMID: 18481388    Free PMC article.
The effects of immunosuppression on regulatory CD4(+)CD25(+) T cells: impact on immunosuppression selection in transplantation.
Aqeel Javeed, Yong Zhao.
Mol Diagn Ther, 2008 May 31; 12(3). PMID: 18510380
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.
Brian Kavanagh, Shaun O'Brien, +6 authors, Lawrence Fong.
Blood, 2008 Jun 05; 112(4). PMID: 18523152    Free PMC article.
T-bet plays a key role in NK-mediated control of melanoma metastatic disease.
Miriam B F Werneck, Geanncarlo Lugo-Villarino, +2 authors, Laurie H Glimcher.
J Immunol, 2008 Jun 05; 180(12). PMID: 18523263    Free PMC article.
Phase Ib trial assessing autologous, tumor-pulsed dendritic cells as a vaccine administered with or without IL-2 in patients with metastatic melanoma.
Bruce G Redman, Alfred E Chang, +5 authors, James J Mulé.
J Immunother, 2008 Jun 06; 31(6). PMID: 18528294    Free PMC article.
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
Wendy W C van Maren, Joannes F M Jacobs, +2 authors, Gosse J Adema.
Immunology, 2008 Jun 11; 124(4). PMID: 18540962    Free PMC article.
In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.
Jagadeesh Bayry, Elma Z Tchilian, +8 authors, David F Tough.
Proc Natl Acad Sci U S A, 2008 Jul 16; 105(29). PMID: 18621704    Free PMC article.
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.
Sergio A Quezada, Karl S Peggs, +3 authors, James P Allison.
J Exp Med, 2008 Aug 30; 205(9). PMID: 18725522    Free PMC article.
Highly Cited.
Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells.
Richard G Carroll, Carmine Carpenito, +9 authors, Carl H June.
PLoS One, 2008 Sep 27; 3(9). PMID: 18818761    Free PMC article.
Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma.
Yi-Ling Chen, Jung-Hua Fang, Ming-Derg Lai, Yan-Shen Shan.
World J Gastroenterol, 2008 Oct 16; 14(38). PMID: 18855977    Free PMC article.
Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity.
John S Cho, Jeffrey V Hsu, Sherie L Morrison.
Cancer Immunol Immunother, 2008 Nov 20; 58(7). PMID: 19018533    Free PMC article.
The role of NKT cells in tumor immunity.
Masaki Terabe, Jay A Berzofsky.
Adv Cancer Res, 2008 Dec 06; 101. PMID: 19055947    Free PMC article.
Highly Cited. Review.
Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells.
Chi-Mu Chuang, Talia Hoory, +3 authors, Chien-Fu Hung.
Vaccine, 2008 Dec 06; 27(5). PMID: 19056449    Free PMC article.
In vitro induction of T cells that are resistant to A2 adenosine receptor-mediated immunosuppression.
Akio Ohta, J Kjaergaard, +6 authors, M Sitkovsky.
Br J Pharmacol, 2008 Dec 17; 156(2). PMID: 19076726    Free PMC article.
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.
Marcus C B Tan, Peter S Goedegebuure, +6 authors, David C Linehan.
J Immunol, 2009 Jan 22; 182(3). PMID: 19155524    Free PMC article.
Highly Cited.
Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer.
Kristen M Drescher, Poonam Sharma, +3 authors, Henry T Lynch.
Fam Cancer, 2009 Jan 24; 8(3). PMID: 19165625
Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.
Marcin Kortylewski, Hong Xin, +6 authors, Hua Yu.
Cancer Cell, 2009 Feb 03; 15(2). PMID: 19185846    Free PMC article.
Highly Cited.
Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma.
Herschel Wallen, John A Thompson, +3 authors, Cassian Yee.
PLoS One, 2009 Mar 10; 4(3). PMID: 19270751    Free PMC article.
Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation.
Ian Horkheimer, Michael Quigley, +3 authors, Yiping Yang.
Blood, 2009 Mar 13; 113(21). PMID: 19279333    Free PMC article.
Costimulatory and coinhibitory receptors in anti-tumor immunity.
Gregory Driessens, Justin Kline, Thomas F Gajewski.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426219    Free PMC article.
Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice.
Halvor S McGee, Jehad H Edwan, Devendra K Agrawal.
Am J Respir Cell Mol Biol, 2009 May 19; 42(3). PMID: 19448155    Free PMC article.
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.
C Coquerelle, G Oldenhove, +6 authors, M Moser.
Gut, 2009 Jun 10; 58(10). PMID: 19505881    Free PMC article.
Anti-CTLA4 Antibody Clinical Trials in Melanoma.
Antoni Ribas.
Update Cancer Ther, 2007 Sep 01; 2(3). PMID: 19543441    Free PMC article.
High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.
Andrew G Brandmaier, Wolfgang W Leitner, +3 authors, Christopher E Touloukian.
J Immunother, 2009 Jun 30; 32(7). PMID: 19561540    Free PMC article.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Karl S Peggs, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407    Free PMC article.
Highly Cited.
The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients.
Amy B Heimberger, John H Sampson.
Expert Opin Biol Ther, 2009 Jul 14; 9(8). PMID: 19591631    Free PMC article.
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
K S Peggs, S A Quezada, J P Allison.
Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765    Free PMC article.
Association of cytotoxic T lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer.
Ruiping Hou, Bangwei Cao, +5 authors, Ziping Chen.
Mol Biol Rep, 2009 Aug 19; 37(1). PMID: 19688278
Cancer immunotherapy: the role regulatory T cells play and what can be done to overcome their inhibitory effects.
Ulf Petrausch, Christian H Poehlein, +20 authors, Bernard A Fox.
Curr Mol Med, 2009 Aug 20; 9(6). PMID: 19689294    Free PMC article.
An enteric pathogen Salmonella enterica serovar Typhimurium suppresses tumor growth by downregulating CD44high and CD4T regulatory (Treg) cell expression in mice: the critical role of lipopolysaccharide and Braun lipoprotein in modulating tumor growth.
T Liu, A K Chopra.
Cancer Gene Ther, 2009 Aug 29; 17(2). PMID: 19713997    Free PMC article.
Enhancing the efficacy of cancer vaccines in urologic oncology: new directions.
Sergei Kusmartsev, Johannes Vieweg.
Nat Rev Urol, 2009 Sep 09; 6(10). PMID: 19736551
Autologous MUC1-specific Th1 effector cell immunotherapy induces differential levels of systemic TReg cell subpopulations that result in increased ovarian cancer patient survival.
Mark J Dobrzanski, Kathleen A Rewers-Felkins, +5 authors, Stephen E Wright.
Clin Immunol, 2009 Sep 19; 133(3). PMID: 19762283    Free PMC article.
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.
Franco R D'Alessio, Kenji Tsushima, +8 authors, Landon S King.
J Clin Invest, 2009 Sep 23; 119(10). PMID: 19770521    Free PMC article.
Highly Cited.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
William Humphries, Jun Wei, John H Sampson, Amy B Heimberger.
Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972    Free PMC article.
Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.
Matthew N Davies, Jagadeesh Bayry, +7 authors, Darren R Flower.
PLoS One, 2009 Dec 17; 4(11). PMID: 20011659    Free PMC article.
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Eduardo J Villablanca, Laura Raccosta, +15 authors, Vincenzo Russo.
Nat Med, 2009 Dec 29; 16(1). PMID: 20037595
Antibodies designed as effective cancer vaccines.
R L Metheringham, V A Pudney, +3 authors, L G Durrant.
MAbs, 2010 Jan 05; 1(1). PMID: 20046577    Free PMC article.
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
Ying Xie, Akgül Akpinarli, +6 authors, Paul Andrew Antony.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156973    Free PMC article.
Highly Cited.
The role of regulatory T cells in cancer.
Tai-You Ha.
Immune Netw, 2010 Feb 17; 9(6). PMID: 20157609    Free PMC article.
Reduced skin homing by functional Treg in vitiligo.
Jared Klarquist, Cecele J Denman, +7 authors, I Caroline Le Poole.
Pigment Cell Melanoma Res, 2010 Feb 24; 23(2). PMID: 20175879    Free PMC article.
DNA vaccines: developing new strategies against cancer.
Daniela Fioretti, Sandra Iurescia, Vito Michele Fazio, Monica Rinaldi.
J Biomed Biotechnol, 2010 Apr 07; 2010. PMID: 20368780    Free PMC article.
Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells.
A-S Bergot, A Durgeau, +3 authors, D Klatzmann.
Cancer Gene Ther, 2010 May 15; 17(9). PMID: 20467452    Free PMC article.
RNA vaccines in cancer treatment.
Anita Bringmann, Stefanie Andrea Erika Held, Annkristin Heine, Peter Brossart.
J Biomed Biotechnol, 2010 Jul 14; 2010. PMID: 20625504    Free PMC article.
B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Pei-Yi Lin, Lishi Sun, +11 authors, Tyler J Curiel.
J Immunol, 2010 Aug 06; 185(5). PMID: 20686128    Free PMC article.
Trends in cancer immunotherapy.
Joseph F Murphy.
Clin Med Insights Oncol, 2010 Aug 13; 4. PMID: 20703326    Free PMC article.
Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer.
Jennifer L Gnerlich, Jonathan B Mitchem, +8 authors, David C Linehan.
J Immunol, 2010 Sep 02; 185(7). PMID: 20805420    Free PMC article.
Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells.
Drew J Roberts, Nathan A Franklin, +4 authors, Timothy N J Bullock.
J Immunother, 2010 Sep 16; 33(8). PMID: 20842060    Free PMC article.
Extended dose ipilimumab with a peptide vaccine: immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma.
Amod A Sarnaik, Bin Yu, +9 authors, Jeffrey S Weber.
Clin Cancer Res, 2010 Nov 26; 17(4). PMID: 21106722    Free PMC article.
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Nona Janikashvili, Collin J LaCasse, +7 authors, Emmanuel Katsanis.
Blood, 2010 Dec 03; 117(5). PMID: 21123824    Free PMC article.
CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with -318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients.
Shaoqiong Duan, Guoyu Zhang, +11 authors, Fanfan Xing.
Mol Biol Rep, 2010 Dec 17; 38(8). PMID: 21161390
A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4(+)FOXP3(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix.
Walayat Shah, Xiaofei Yan, +3 authors, Yili Wang.
Cell Mol Immunol, 2011 Jan 05; 8(1). PMID: 21200385    Free PMC article.
T cell-tumor interaction directs the development of immunotherapies in head and neck cancer.
A E Albers, L Strauss, +2 authors, A M Kaufmann.
Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234340    Free PMC article.
Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer.
Ruud P M Dings, Kieng B Vang, +7 authors, Kevin H Mayo.
Clin Cancer Res, 2011 Jan 22; 17(10). PMID: 21252159    Free PMC article.
Whole recombinant yeast vaccine induces antitumor immunity and improves survival in a genetically engineered mouse model of melanoma.
A Tanaka, J D Jensen, +6 authors, M Fujita.
Gene Ther, 2011 Mar 11; 18(8). PMID: 21390072    Free PMC article.
Molecular profiling of melanoma and the evolution of patient-specific therapy.
Thomas F Gajewski.
Semin Oncol, 2011 Mar 23; 38(2). PMID: 21421113    Free PMC article.
Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity.
Gordana Radosavljevic, Ivan Jovanovic, +5 authors, Miodrag L Lukic.
Clin Exp Metastasis, 2011 Mar 29; 28(5). PMID: 21442355
Depletion of CD25⁺ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma.
Weiqing Jing, Xiaocai Yan, +2 authors, Bryon D Johnson.
Blood, 2011 Apr 28; 117(25). PMID: 21521781    Free PMC article.
TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo.
Sayuri Yamazaki, Kohei Okada, +3 authors, Tsukasa Seya.
PLoS One, 2011 May 03; 6(4). PMID: 21533081    Free PMC article.
Immunological and clinical effects of vaccines targeting p53-overexpressing malignancies.
R Vermeij, N Leffers, +3 authors, H W Nijman.
J Biomed Biotechnol, 2011 May 05; 2011. PMID: 21541192    Free PMC article.
Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice.
Jinlin Liu, Ning Zhang, +6 authors, Honglin Wang.
PLoS One, 2011 May 12; 6(4). PMID: 21559338    Free PMC article.
Immunomodulatory effects of cyclophosphamide and implementations for vaccine design.
Antonella Sistigu, Sophie Viaud, +3 authors, Laurence Zitvogel.
Semin Immunopathol, 2011 May 26; 33(4). PMID: 21611872
Highly Cited. Review.
Immunosuppressive tumor microenvironment in cervical cancer patients.
Sytse J Piersma.
Cancer Microenviron, 2011 Jun 01; 4(3). PMID: 21626415    Free PMC article.
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Marianela Candolfi, Kurt M Kroeger, +11 authors, Maria G Castro.
Anticancer Agents Med Chem, 2011 Jun 29; 11(8). PMID: 21707497    Free PMC article.
Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32.
Y Qu, J L Taylor, A Bose, W J Storkus.
Cancer Gene Ther, 2011 Jul 16; 18(9). PMID: 21760628    Free PMC article.
Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
Duane A Mitchell, Xiuyu Cui, +13 authors, John H Sampson.
Blood, 2011 Jul 20; 118(11). PMID: 21768296    Free PMC article.
Regulatory T cell: a protection for tumour cells.
Yi Wang, Yushui Ma, +4 authors, Xizhong Shen.
J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966    Free PMC article.
Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity.
Huanfa Yi, Chunqing Guo, +7 authors, Xiang-Yang Wang.
Cancer Res, 2011 Sep 15; 71(21). PMID: 21914786    Free PMC article.
Therapeutic options in cutaneous melanoma: latest developments.
Rodabe N Amaria, Karl D Lewis, Rene Gonzalez.
Ther Adv Med Oncol, 2011 Oct 01; 3(5). PMID: 21957431    Free PMC article.
Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.
Scott K Pruitt, David Boczkowski, +5 authors, Smita Nair.
Eur J Immunol, 2011 Oct 27; 41(12). PMID: 22028176    Free PMC article.
Immune recovery after cyclophosphamide treatment in multiple myeloma: implication for maintenance immunotherapy.
Amir Sharabi, Nechama Haran-Ghera.
Bone Marrow Res, 2011 Nov 03; 2011. PMID: 22046558    Free PMC article.
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma.
Xiang-Yang Wang, Daming Zuo, Devanand Sarkar, Paul B Fisher.
Expert Opin Pharmacother, 2011 Nov 15; 12(17). PMID: 22077831    Free PMC article.
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524    Free PMC article.
Regulatory T cells and IL-10 independently counterregulate cytotoxic T lymphocyte responses induced by transcutaneous immunization.
Pamela Stein, Michael Weber, +7 authors, Markus P Radsak.
PLoS One, 2011 Nov 25; 6(11). PMID: 22114725    Free PMC article.
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment.
Christopher Jackson, Jacob Ruzevick, +2 authors, Michael Lim.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190972    Free PMC article.
Cancer immunotherapy.
Thomas F Gajewski.
Mol Oncol, 2012 Jan 18; 6(2). PMID: 22248437    Free PMC article.
Myeloid suppressor cells and immune modulation in lung cancer.
Minu K Srivastava, Åsa Andersson, +4 authors, Sherven Sharma.
Immunotherapy, 2012 Mar 10; 4(3). PMID: 22401635    Free PMC article.
Targeting costimulatory molecules to improve antitumor immunity.
Daria Capece, Daniela Verzella, +2 authors, Edoardo Alesse.
J Biomed Biotechnol, 2012 Apr 14; 2012. PMID: 22500111    Free PMC article.
CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients.
Andrew J Rech, Rosemarie Mick, +13 authors, Robert H Vonderheide.
Sci Transl Med, 2012 May 18; 4(134). PMID: 22593175    Free PMC article.
Highly Cited.
Ipilimumab pharmacotherapy in patients with metastatic melanoma.
Joanne M Jeter, Lee D Cranmer, Evan M Hersh.
Clin Med Insights Oncol, 2012 Aug 21; 6. PMID: 22904648    Free PMC article.
Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications.
Luis de la Cruz-Merino, Marylène Lejeune, +6 authors, Tomás Álvaro.
Clin Dev Immunol, 2012 Aug 29; 2012. PMID: 22927872    Free PMC article.
Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma.
Anna Hooijkaas, Jules Gadiot, +3 authors, Christian U Blank.
Oncoimmunology, 2012 Aug 31; 1(5). PMID: 22934253    Free PMC article.
T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.
James P Hindley, Emma Jones, +11 authors, Awen M Gallimore.
Cancer Res, 2012 Sep 11; 72(21). PMID: 22962270    Free PMC article.
Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration.
John Karavitis, Laura M Hix, +3 authors, Ming Zhang.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029485    Free PMC article.
Immunology beats cancer: a blueprint for successful translation.
Drew M Pardoll.
Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205    Free PMC article.
Immunotherapies: the blockade of inhibitory signals.
Yan-Ling Wu, Jing Liang, +2 authors, Hiroshi Sugiyama.
Int J Biol Sci, 2012 Dec 01; 8(10). PMID: 23197939    Free PMC article.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Dietmar M W Zaiss, Jorg van Loosdregt, +7 authors, Alice J A M Sijts.
Immunity, 2013 Jan 22; 38(2). PMID: 23333074    Free PMC article.
Highly Cited.
Influence of tumors on protective anti-tumor immunity and the effects of irradiation.
Gemma A Foulds, Jürgen Radons, +2 authors, Alan G Pockley.
Front Oncol, 2013 Feb 05; 3. PMID: 23378947    Free PMC article.
CTLA-4 blockade in tumor models: an overview of preclinical and translational research.
Joseph F Grosso, Maria N Jure-Kunkel.
Cancer Immun, 2013 Feb 08; 13. PMID: 23390376    Free PMC article.
Highly Cited. Review.
Antigen choice determines vaccine-induced generation of immunogenic versus tolerogenic dendritic cells that are marked by differential expression of pancreatic enzymes.
Adam M Farkas, Douglas M Marvel, Olivera J Finn.
J Immunol, 2013 Feb 20; 190(7). PMID: 23420890    Free PMC article.
Higher frequencies of GARP(+)CTLA-4(+)Foxp3(+) T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality.
Suresh Kalathil, Amit A Lugade, +2 authors, Yasmin Thanavala.
Cancer Res, 2013 Feb 21; 73(8). PMID: 23423978    Free PMC article.
Highly Cited.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease.
Michael Weber, Corinna Lupp, +6 authors, Markus P Radsak.
PLoS One, 2013 Mar 14; 8(3). PMID: 23483980    Free PMC article.
Adenocarcinoma contains more immune tolerance regulatory t-cell lymphocytes (versus squamous carcinoma) in non-small-cell lung cancer.
Candice C Black, Mary Jo Turk, Konstantin Dragnev, James R Rigas.
Lung, 2013 Mar 16; 191(3). PMID: 23494387
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.
Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536636    Free PMC article.
Highly Cited.
Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer.
Vincent Lavoué, Aurélie Thédrez, +6 authors, Florian Cabillic.
J Transl Med, 2013 Jun 15; 11. PMID: 23763830    Free PMC article.
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer.
L Bracci, G Schiavoni, A Sistigu, F Belardelli.
Cell Death Differ, 2013 Jun 22; 21(1). PMID: 23787994    Free PMC article.
Highly Cited. Review.
An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy.
Khairunadwa Jemon, Vivienne Young, +5 authors, Merilyn Hibma.
PLoS One, 2013 Jun 27; 8(6). PMID: 23799135    Free PMC article.
Immunochemoradiotherapy for patients with oral squamous cell carcinoma: augmentation of OK-432-induced helper T cell 1 response by 5-FU and X-ray irradiation.
Tomoyuki Tano, Masato Okamoto, +11 authors, Yutaka Kawakami.
Neoplasia, 2013 Jul 03; 15(7). PMID: 23814492    Free PMC article.
Deciphering and reversing tumor immune suppression.
Greg T Motz, George Coukos.
Immunity, 2013 Jul 31; 39(1). PMID: 23890064    Free PMC article.
Highly Cited. Review.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells.
Lewis Zhichang Shi, Nishan S Kalupahana, +4 authors, Hongbo Chi.
Proc Natl Acad Sci U S A, 2013 Aug 07; 110(34). PMID: 23918371    Free PMC article.
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.
Jagadeesh Bayry.
Virusdisease, 2014 Jan 16; 25(1). PMID: 24426307    Free PMC article.
Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+ T-cell effector differentiation by IL-2 modulation.
Alice McNally, Michael McNally, +2 authors, Raymond J Steptoe.
PLoS One, 2014 Jan 24; 9(1). PMID: 24454872    Free PMC article.
Immune modulation in humans: implications for type 1 diabetes mellitus.
Bart O Roep, Timothy I M Tree.
Nat Rev Endocrinol, 2014 Jan 29; 10(4). PMID: 24468651
Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells.
Fumika Takasato, Rimpei Morita, +5 authors, Akihiko Yoshimura.
PLoS One, 2014 Feb 06; 9(2). PMID: 24498362    Free PMC article.
STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications.
Jennifer E Kim, Mira Patel, +2 authors, Michael Lim.
Cancers (Basel), 2014 Feb 13; 6(1). PMID: 24518612    Free PMC article.
Developing effective tumor vaccines: basis, challenges and perspectives.
Qingwen Xu, Weifeng Chen.
Front Med China, 2007 Feb 01; 1(1). PMID: 24557610
Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy.
David Escors.
New J Sci, 2014 Mar 19; 2014. PMID: 24634791    Free PMC article.
Differential ability of surface and endosomal TLRs to induce CD8 T cell responses in vivo.
Rajakumar Mandraju, Sean Murray, James Forman, Chandrashekhar Pasare.
J Immunol, 2014 Apr 02; 192(9). PMID: 24688022    Free PMC article.
Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.
Linda C Sandin, Fredrik Eriksson, +3 authors, Sara M Mangsbo.
Oncoimmunology, 2014 Apr 05; 3(1). PMID: 24701377    Free PMC article.
The ThPOK transcription factor differentially affects the development and function of self-specific CD8(+) T cells and regulatory CD4(+) T cells.
Yuh-Ching Twu, Hung-Sia Teh.
Immunology, 2014 Apr 09; 141(3). PMID: 24708418    Free PMC article.
Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets.
Florian Wimmers, Gerty Schreibelt, +2 authors, I Jolanda M De Vries.
Front Immunol, 2014 May 02; 5. PMID: 24782868    Free PMC article.
Rational combinations of immunotherapeutics that target discrete pathways.
Stefani Spranger, Thomas Gajewski.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829752    Free PMC article.
Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO.
Anle Zhang, Yuanhong Zheng, +5 authors, Jianhui Tian.
J Cancer Res Clin Oncol, 2014 Jul 02; 140(11). PMID: 24980548
Ipilimumab augments antitumor activity of bispecific antibody-armed T cells.
Hiroshi Yano, Archana Thakur, +3 authors, Lawrence G Lum.
J Transl Med, 2014 Jul 11; 12. PMID: 25008236    Free PMC article.
Prognostic value of peripheral and local forkhead box P3+ regulatory T cells in patients with non-small-cell lung cancer.
Takeo Hasegawa, Hiroyuki Suzuki, +7 authors, Mitsukazu Gotoh.
Mol Clin Oncol, 2014 Jul 24; 2(5). PMID: 25054031    Free PMC article.
Regulatory T cells in B-cell-deficient and wild-type mice differ functionally and in expression of cell surface markers.
Jason S Ellis, Helen Braley-Mullen.
Immunology, 2014 Oct 17; 144(4). PMID: 25318356    Free PMC article.
Depletion of Foxp3+ Regulatory T Cells Promotes Profibrogenic Milieu of Cholestasis-Induced Liver Injury.
Yoon Seok Roh, Surim Park, Chae Woong Lim, Bumseok Kim.
Dig Dis Sci, 2014 Nov 25; 60(7). PMID: 25416630
Immune profiling and cancer post transplantation.
Christopher Martin Hope, Patrick Toby H Coates, Robert Peter Carroll.
World J Nephrol, 2015 Feb 11; 4(1). PMID: 25664246    Free PMC article.
Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.
Dietmar M W Zaiss, William C Gause, Lisa C Osborne, David Artis.
Immunity, 2015 Feb 19; 42(2). PMID: 25692699    Free PMC article.
Highly Cited. Review.
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal.
Stefanie N Linch, Michael J McNamara, William L Redmond.
Front Oncol, 2015 Mar 13; 5. PMID: 25763356    Free PMC article.
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Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report.
Daniela A Bota, Daniela Alexandru-Abrams, +6 authors, Apostolos Stathopoulos.
Perm J, 2015 Mar 19; 19(2). PMID: 25785641    Free PMC article.
Immunotherapy in Cancer: A Combat between Tumors and the Immune System; You Win Some, You Lose Some.
Florencia Paula Madorsky Rowdo, Antonela Baron, Mariela Urrutia, José Mordoh.
Front Immunol, 2015 Apr 11; 6. PMID: 25859247    Free PMC article.
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity.
Alice O Kamphorst, Koichi Araki, Rafi Ahmed.
Vaccine, 2015 May 30; 33 Suppl 2. PMID: 26022562    Free PMC article.
T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it?
Florian Anzengruber, Pinar Avci, Lucas Freitas de Freitas, Michael R Hamblin.
Photochem Photobiol Sci, 2015 Jun 13; 14(8). PMID: 26062987    Free PMC article.
Highly clonal regulatory T-cell population in follicular lymphoma - inverse correlation with the diversity of CD8+ T cells.
Xiao Liu, Girish Venkataraman, +5 authors, Justin Kline.
Oncoimmunology, 2015 Jul 15; 4(5). PMID: 26155390    Free PMC article.
Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations.
W Joost Lesterhuis, Catherine Rinaldi, +8 authors, Richard A Lake.
Sci Rep, 2015 Jul 22; 5. PMID: 26193793    Free PMC article.
Therapeutic cancer vaccines.
Cornelis J M Melief, Thorbald van Hall, +2 authors, Sjoerd H van der Burg.
J Clin Invest, 2015 Jul 28; 125(9). PMID: 26214521    Free PMC article.
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Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites.
Powell Perng, Michael Lim.
Front Oncol, 2015 Jul 29; 5. PMID: 26217588    Free PMC article.
Denileukin Diftitox (Ontak) as Maintenance Therapy for Peripheral T-Cell Lymphomas: Three Cases with Sustained Remission.
Alejandra C Fuentes, Ellen Szwed, +3 authors, Nam H Dang.
Case Rep Oncol Med, 2015 Aug 05; 2015. PMID: 26240767    Free PMC article.
Cancer and the Immune System: Basic Concepts and Targets for Intervention.
Drew Pardoll.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320058    Free PMC article.
Highly Cited. Review.
Clinical significance of expanded Foxp3⁺ Helios⁻ regulatory T cells in patients with non-small cell lung cancer.
Satoshi Muto, Yuki Owada, +11 authors, Mitsukazu Gotoh.
Int J Oncol, 2015 Oct 16; 47(6). PMID: 26460798    Free PMC article.
Regulatory T cells in the immunotherapy of melanoma.
Zhengxiao Ouyang, Hongwei Wu, +3 authors, Gang Huang.
Tumour Biol, 2015 Oct 31; 37(1). PMID: 26515336
Translating Treg Therapy in Humanized Mice.
Susanne A Hahn, Iris Bellinghausen, Bettina Trinschek, Christian Becker.
Front Immunol, 2015 Dec 24; 6. PMID: 26697017    Free PMC article.
Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice.
Stefanie N Linch, Melissa J Kasiewicz, +3 authors, William L Redmond.
Proc Natl Acad Sci U S A, 2016 Jan 06; 113(3). PMID: 26729864    Free PMC article.
Signaling in T cells - is anything the m(a)TOR with the picture(s)?
Mark Boothby.
F1000Res, 2016 Mar 08; 5. PMID: 26949528    Free PMC article.
Leveraging immunotherapy for the treatment of gynecologic cancers in the era of precision medicine.
Dmitriy Zamarin, Amir A Jazaeri.
Gynecol Oncol, 2016 Mar 27; 141(1). PMID: 27016233    Free PMC article.
Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research.
Sung Jong Lee, Andrew Yang, T C Wu, Chien Fu Hung.
J Gynecol Oncol, 2016 Jun 23; 27(5). PMID: 27329199    Free PMC article.
Single dose denileukin diftitox does not enhance vaccine-induced T cell responses or effectively deplete Tregs in advanced melanoma: immune monitoring and clinical results of a randomized phase II trial.
Jason J Luke, Yuanyuan Zha, Karen Matijevich, Thomas F Gajewski.
J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330808    Free PMC article.
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges.
Chrisann Kyi, Michael A Postow.
Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349981    Free PMC article.
Highly Cited. Review.
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade.
Wei Xue, Rachael L Metheringham, +5 authors, Lindy G Durrant.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471648    Free PMC article.
Oral Squamous Carcinoma Cells Express B7-H1 and B7-DC Receptors in Vivo.
Sabine Groeger, H P Howaldt, +3 authors, J Meyle.
Pathol Oncol Res, 2016 Aug 09; 23(1). PMID: 27498988
Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1.
K Hasegawa, M Tagawa, +6 authors, M Numasaki.
Cancer Gene Ther, 2016 Aug 27; 23(8). PMID: 27561689
Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop.
Roch Houot, Philippe Gaulard, +18 authors, Daniel Olive.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622041    Free PMC article.
Is There Still Room for Cancer Vaccines at the Era of Checkpoint Inhibitors.
Soumaya Karaki, Marie Anson, +4 authors, Eric Tartour.
Vaccines (Basel), 2016 Nov 10; 4(4). PMID: 27827885    Free PMC article.
Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity.
W Joost Lesterhuis, Anthony Bosco, +3 authors, Richard A Lake.
Nat Rev Drug Discov, 2017 Jan 07; 16(4). PMID: 28057932
Highly Cited. Review.
Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma.
Antonio Miguel, Luis Sendra, +5 authors, Salvador F Aliño.
Onco Targets Ther, 2017 Feb 09; 10. PMID: 28176947    Free PMC article.
Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells.
Vinodh Kannappan, Kate Butcher, +3 authors, Kesley Attridge.
Cancer Immunol Immunother, 2017 Feb 28; 66(5). PMID: 28239749    Free PMC article.
Transient Treg depletion enhances therapeutic anti-cancer vaccination.
Scott A Fisher, Wayne J Aston, +11 authors, Richard A Lake.
Immun Inflamm Dis, 2017 Mar 03; 5(1). PMID: 28250921    Free PMC article.
IL-32 induces indoleamine 2,3-dioxygenase+CD1c+ dendritic cells and indoleamine 2,3-dioxygenase+CD163+ macrophages: Relevance to mycosis fungoides progression.
Hanako Ohmatsu, Daniel Humme, +4 authors, James G Krueger.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344860    Free PMC article.
T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy.
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Lab Invest, 2017 Mar 28; 97(6). PMID: 28346400    Free PMC article.
Highly Cited. Review.
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Frederick Arce Vargas, Andrew J S Furness, +29 authors, Sergio A Quezada.
Immunity, 2017 Apr 16; 46(4). PMID: 28410988    Free PMC article.
Highly Cited.
Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy.
Meiqin Wang, Ivana V Yang, +4 authors, Erwin W Gelfand.
J Allergy Clin Immunol, 2017 May 10; 141(2). PMID: 28479331    Free PMC article.
Delivering safer immunotherapies for cancer.
Lauren Milling, Yuan Zhang, Darrell J Irvine.
Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888    Free PMC article.
Highly Cited. Review.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656    Free PMC article.
The Immune System's Contribution to the Clinical Efficacy of EGFR Antagonist Treatment.
Felicity MacDonald, Dietmar M W Zaiss.
Front Pharmacol, 2017 Oct 04; 8. PMID: 28970798    Free PMC article.
Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression.
Wei Li, Jun Han, Hong Wu.
Chronic Dis Transl Med, 2017 Oct 25; 2(2). PMID: 29063027    Free PMC article.
CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy.
Anna Wasiuk, James Testa, +9 authors, Li-Zhen He.
J Immunol, 2017 Nov 08; 199(12). PMID: 29109120    Free PMC article.
The opposing roles of CD4+ T cells in anti-tumour immunity.
Tomasz Ahrends, Jannie Borst.
Immunology, 2018 Apr 28;. PMID: 29700809    Free PMC article.
Novel tumour antigens and the development of optimal vaccine design.
Victoria A Brentville, Suha Atabani, Katherine Cook, Lindy G Durrant.
Ther Adv Vaccines Immunother, 2018 Jul 13; 6(2). PMID: 29998219    Free PMC article.
Genetics and biology of prostate cancer.
Guocan Wang, Di Zhao, Denise J Spring, Ronald A DePinho.
Genes Dev, 2018 Sep 06; 32(17-18). PMID: 30181359    Free PMC article.
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.
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Immunity, 2018 Oct 07; 49(4). PMID: 30291029    Free PMC article.
Highly Cited.
Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma.
Claudia Robles-Planells, Sofia A Michelson, +15 authors, Claudio Acuña-Castillo.
Front Pharmacol, 2019 Nov 07; 10. PMID: 31695610    Free PMC article.
Cutting Edge: Tumor-specific CD8+ T cells infiltrating prostatic tumors are induced to become suppressor cells.
Kimberly A Shafer-Weaver, Michael J Anderson, +3 authors, Arthur A Hurwitz.
J Immunol, 2009 Oct 06; 183(8). PMID: 19801511    Free PMC article.
Bioactive Compounds: Natural Defense Against Cancer?
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Biomolecules, 2019 Nov 27; 9(12). PMID: 31766399    Free PMC article.
Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms.
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Eur J Immunol, 2011 Jun 29; 41(10). PMID: 21710477    Free PMC article.
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.
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Nat Immunol, 2020 Feb 19; 21(3). PMID: 32066953    Free PMC article.
TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.
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Proc Natl Acad Sci U S A, 2019 May 12; 116(21). PMID: 31076558    Free PMC article.
CTLA-4: a moving target in immunotherapy.
Behzad Rowshanravan, Neil Halliday, David M Sansom.
Blood, 2017 Nov 10; 131(1). PMID: 29118008    Free PMC article.
Highly Cited. Review.
Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy.
Rachael M Zemek, Wee Loong Chin, +3 authors, W Joost Lesterhuis.
Front Immunol, 2020 Mar 07; 11. PMID: 32133005    Free PMC article.
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome.
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Leukemia, 2018 Oct 26; 33(5). PMID: 30356161    Free PMC article.
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity.
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Proc Natl Acad Sci U S A, 2019 Feb 15; 116(10). PMID: 30760587    Free PMC article.
Integrated cancer tissue engineering models for precision medicine.
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PLoS One, 2019 May 11; 14(5). PMID: 31075118    Free PMC article.
Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy.
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J Transl Med, 2020 Mar 30; 18(1). PMID: 32220256    Free PMC article.
Distribution of Regulatory T-Cells and Other Phenotypes of T-Cells in Tumors and Regional Lymph Nodes of Colorectal Cancer Patients.
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In Vivo, 2020 Mar 01; 34(2). PMID: 32111794    Free PMC article.
LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma.
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J Immunother Cancer, 2020 Apr 03; 8(1). PMID: 32234847    Free PMC article.
Enhancing immune responses to tumor-associated antigens.
Jack P Higgins, Michael B Bernstein, James W Hodge.
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Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia.
Yuling Wan, Congxiao Zhang, +8 authors, Jianxiang Wang.
BMC Cancer, 2020 May 28; 20(1). PMID: 32456622    Free PMC article.
Therapy-Induced Changes in CXCR4 Expression in Tumor Xenografts Can Be Monitored Noninvasively with N-[11C]Methyl-AMD3465 PET.
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Mol Imaging Biol, 2019 Dec 06; 22(4). PMID: 31802362    Free PMC article.
Encapsulated Checkpoint Blocker Before Chemotherapy: The Optimal Sequence of Anti-CTLA-4 and Doxil Combination Therapy.
Reza Alimohammadi, Razieh Alibeigi, +4 authors, Seyed Amir Jalali.
Int J Nanomedicine, 2020 Aug 18; 15. PMID: 32801691    Free PMC article.
Treg Enhancing Therapies to Treat Autoimmune Diseases.
Peter J Eggenhuizen, Boaz H Ng, Joshua D Ooi.
Int J Mol Sci, 2020 Sep 27; 21(19). PMID: 32977677    Free PMC article.
Cancer vaccine strategies: translation from mice to human clinical trials.
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Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody.
Han Gao, Haiyan Cai, +7 authors, Aiwu Zhou.
Cell Discov, 2020 Dec 11; 6(1). PMID: 33298884    Free PMC article.
Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis.
Fengyi Xiao, Xishi Liu, Sun-Wei Guo.
Front Immunol, 2021 Jan 01; 11. PMID: 33381124    Free PMC article.
The role of regulatory T lymphocytes in immune control of MC-2 fibrosarcoma.
Tomislav Jukić, Ana Jurin Martić, +4 authors, Mislav Jurin.
Acta Clin Croat, 2021 Jan 19; 59(2). PMID: 33456124    Free PMC article.
A Functional Food Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Inflammatory Colorectal Cancer in Mice.
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Onco Targets Ther, 2021 Mar 06; 14. PMID: 33664579    Free PMC article.
Searching for Peptide Inhibitors of T Regulatory Cell Activity by Targeting Specific Domains of FOXP3 Transcription Factor.
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Biomedicines, 2021 Mar 07; 9(2). PMID: 33671179    Free PMC article.
Bilateral murine tumor models for characterizing the response to immune checkpoint blockade.
Rachael M Zemek, Vanessa S Fear, +9 authors, W Joost Lesterhuis.
Nat Protoc, 2020 Apr 03; 15(5). PMID: 32238953
A Novel CAR Expressing NK Cell Targeting CD25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers.
Moein Dehbashi, Zohreh Hojati, +5 authors, Mazdak Ganjalikhani-Hakemi.
Front Oncol, 2021 Jun 01; 11. PMID: 34055618    Free PMC article.
Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors.
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Genome Med, 2021 Aug 12; 13(1). PMID: 34376232    Free PMC article.
Curcumin as an Adjuvant to Cancer Immunotherapy.
Silpita Paul, Gaurisankar Sa.
Front Oncol, 2021 Sep 07; 11. PMID: 34485117    Free PMC article.
Combination Adjuvants Enhance Recombinant Protein Vaccine Protection against Fungal Infection.
Marcel Wüthrich, Hannah E Dobson, +5 authors, Bruce S Klein.
mBio, 2021 Aug 18; 12(4). PMID: 34399628    Free PMC article.
The Role of Post-Translational Modifications of Chemokines by CD26 in Cancer.
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Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503058    Free PMC article.
Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy.
Hsin-Yu Liu, Christophe Pedros, +3 authors, Amnon Altman.
J Immunother Cancer, 2021 Oct 01; 9(9). PMID: 34588224    Free PMC article.
Cell-Based Regeneration and Treatment of Liver Diseases.
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