Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells

A Iellem ¹, M Mariani , R Lang , H Recalde , P Panina-Bordignon , F Sinigaglia , D D'Ambrosio

Affiliations

¹ Roche Milano Ricerche, Milano I-20132, Italy.

PMID: 11560999
30 References
273 citations

Abstract

Chemokines dictate regional trafficking of functionally distinct T cell subsets. In rodents and humans, a unique subset of CD4(+)CD25(+) cytotoxic T lymphocyte antigen (CTLA)-4(+) regulatory T cells (Treg) has been proposed to control peripheral tolerance. However, the molecular basis of immune suppression and the trafficking properties of Treg cells are still unknown. Here, we determined the chemotactic response profile and chemokine receptor expression of human blood-borne CD4(+)CD25(+) Treg cells. These Treg cells were found to vigorously respond to several inflammatory and lymphoid chemokines. Treg cells specifically express the chemokine receptors CCR4 and CCR8 and represent a major subset of circulating CD4(+) T cells responding to the chemokines macrophage-derived chemokine (MDC)/CCL22, thymus and activation-regulated chemokine (TARC)/CCL17, I-309/CCL1, and to the virokine vMIP-I (ligands of CCR4 and CCR8). Blood-borne CD4(+) T cells that migrate in response to CCL1 and CCL22 exhibit a reduced alloproliferative response, dependent on the increased frequency of Treg cells in the migrated population. Importantly, mature dendritic cells preferentially attract Treg cells among circulating CD4(+) T cells, by secretion of CCR4 ligands CCL17 and CCL22. Overall, these results suggest that CCR4 and/or CCR8 may guide Treg cells to sites of antigen presentation in secondary lymphoid tissues and inflamed areas to attenuate T cell activation.

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Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells. Susanne Stutte, Thomas Quast, +7 authors, Irmgard Förster. less Proc Natl Acad Sci U S A, 2010 Apr 28; 107(19). PMID: 20421491 Free PMC article.
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Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model. D Lys Guilbride, Pawel Gawlinski, Patrick D L Guilbride. PLoS One, 2010 May 27; 5(5). PMID: 20502667 Free PMC article.
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Immune evasion by Kaposi's sarcoma-associated herpesvirus. Hye-Ra Lee, Stacy Lee, +2 authors, Preet M Chaudhary, Parkash Gill, Jae U Jung. less Future Microbiol, 2010 Sep 24; 5(9). PMID: 20860481 Free PMC article. Review.
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Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression. Adam W Mailloux, M Rita I Young. Crit Rev Immunol, 2010 Nov 19; 30(5). PMID: 21083525 Free PMC article. Review.
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Vaccination with photodynamic therapy-treated macrophages induces highly suppressive T-regulatory cells. Oleg E Akilov, Mei X Wu, +4 authors, Tayyaba Hasan. less Photodermatol Photoimmunol Photomed, 2011 Mar 12; 27(2). PMID: 21392113 Free PMC article.
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CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. Christian Weber, Svenja Meiler, +20 authors, Alma Zernecke. less J Clin Invest, 2011 Jun 03; 121(7). PMID: 21633167 Free PMC article.
In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-β secreting DCs is crucial for their enrichment and suppression in tumor immunity. Lin Xu, Wei Xu, Zhenke Wen, Sidong Xiong. PLoS One, 2011 Jun 10; 6(5). PMID: 21655250 Free PMC article.
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. Joel Montane, Loraine Bischoff, +7 authors, C Bruce Verchere. less J Clin Invest, 2011 Jul 09; 121(8). PMID: 21737880 Free PMC article.
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Antibody therapy for Adult T-cell leukemia-lymphoma. Takashi Ishida, Ryuzo Ueda. Int J Hematol, 2011 Oct 14; 94(5). PMID: 21993874
Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease. Natsumi Araya, Tomoo Sato, +4 authors, Yoshihisa Yamano. less Viruses, 2011 Oct 14; 3(9). PMID: 21994794 Free PMC article. Review.
Identification of CCL1 as a Gene Differentially Expressed in CD4 T Cells Expressing TIM-3. Ka Jung Jun, Mi Jin Lee, +3 authors, Sun Park. less Immune Netw, 2011 Nov 01; 11(4). PMID: 22039368 Free PMC article.
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance. Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier. Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524 Free PMC article. Review.
Regulatory T cells accumulate in the lung allergic inflammation and efficiently suppress T-cell proliferation but not Th2 cytokine production. Lucas Faustino, Daniel Mucida, +7 authors, Momtchilo Russo. less Clin Dev Immunol, 2011 Dec 14; 2012. PMID: 22162718 Free PMC article.
Failure to recruit anti-inflammatory CD103+ dendritic cells and a diminished CD4+ Foxp3+ regulatory T cell pool in mice that display excessive lung inflammation and increased susceptibility to Mycobacterium tuberculosis. Chaniya Leepiyasakulchai, Lech Ignatowicz, +2 authors, Markus Sköld. less Infect Immun, 2012 Jan 05; 80(3). PMID: 22215739 Free PMC article.
A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection. Vincent Pedergnana, Antoine Gessain, +6 authors, Sabine Plancoulaine. less Eur J Hum Genet, 2012 Jan 20; 20(6). PMID: 22258534 Free PMC article.
Accumulation of CCR4⁺CTLA-4 FOXP3⁺CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells. Helena Svensson, Veronica Olofsson, +5 authors, Marianne Quiding-Järbrink. less PLoS One, 2012 Feb 10; 7(2). PMID: 22319577 Free PMC article.
Interaction of Bifidobacterium bifidum LMG13195 with HT29 cells influences regulatory-T-cell-associated chemokine receptor expression. Patricia López, Irene González-Rodríguez, +4 authors, Miguel Gueimonde. less Appl Environ Microbiol, 2012 Feb 22; 78(8). PMID: 22344636 Free PMC article.
Immune modulation of inflammatory conditions: regulatory T cells for treatment of GvHD. Doreen Haase, Mireille Starke, +2 authors, Kia Joo Puan, Tuck Siong Lai, Olaf Rotzschke. less Immunol Res, 2012 Mar 16; 53(1-3). PMID: 22418725 Review.
C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity. Catherine Denis, Kathleen Deiteren, +5 authors, Anne-Marie Lambeir. less PLoS One, 2012 Apr 06; 7(3). PMID: 22479563 Free PMC article.
Regulatory T cells in human ovarian cancer. Dong-Jun Peng, Rebecca Liu, Weiping Zou. J Oncol, 2012 Apr 07; 2012. PMID: 22481922 Free PMC article.
Targeting chemokine receptor CCR4 in adult T-cell leukemia-lymphoma and other T-cell lymphomas. Kensei Tobinai, Takeshi Takahashi, Shiro Akinaga. Curr Hematol Malig Rep, 2012 Apr 28; 7(3). PMID: 22538464 Free PMC article. Review.
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Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF. Paul Spear, Amorette Barber, Agnieszka Rynda-Apple, Charles L Sentman. J Immunol, 2012 May 16; 188(12). PMID: 22586039 Free PMC article.
NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells. Ravikumar Muthuswamy, Erik Berk, +7 authors, Pawel Kalinski. less Cancer Res, 2012 May 18; 72(15). PMID: 22593190 Free PMC article.
Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue. Christoph Dürr, Marie Follo, +2 authors, Marco Idzko, Wilfried Reichardt, Robert Zeiser. less Immunology, 2012 Jun 12; 137(1). PMID: 22681312 Free PMC article.
Regulatory T cells in γ irradiation-induced immune suppression. Hugh I McFarland, Montserrat Puig, +5 authors, Amy S Rosenberg. less PLoS One, 2012 Jun 23; 7(6). PMID: 22723935 Free PMC article.
Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer. Helene Pere, Corinne Tanchot, +17 authors, Eric Tartour. less Oncoimmunology, 2012 Jun 28; 1(3). PMID: 22737608 Free PMC article.
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Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC). Baldev Vasir, Corrine Zarwan, +8 authors, David Avigan. less J Immunother, 2012 Aug 16; 35(7). PMID: 22892452 Free PMC article.
The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers. Norio Kawamoto, Hidenori Ohnishi, Naomi Kondo, Jack L Strominger. Int Immunol, 2012 Sep 13; 25(1). PMID: 22968996 Free PMC article.
Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance. C Tanchot, M Terme, +7 authors, E Tartour. less Cancer Microenviron, 2012 Oct 30; 6(2). PMID: 23104434 Free PMC article.
Chemokines shape the immune responses to tuberculosis. Samantha R Slight, Shabaana A Khader. Cytokine Growth Factor Rev, 2012 Nov 22; 24(2). PMID: 23168132 Free PMC article. Review.
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Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation. Brian P McSharry, Selmir Avdic, Barry Slobedman. Viruses, 2012 Dec 04; 4(11). PMID: 23202490 Free PMC article. Review.
Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells. Jens Loebbermann, Lydia Durant, +2 authors, Hannah Thornton, Cecilia Johansson, Peter J Openshaw. less Proc Natl Acad Sci U S A, 2013 Feb 06; 110(8). PMID: 23382205 Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Mark J Dobrzanski. Front Oncol, 2013 Mar 28; 3. PMID: 23533029 Free PMC article.
Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs. Arya Biragyn, Monica Bodogai, +7 authors, Catalina Lee-Chang. less J Immunother, 2013 Apr 23; 36(4). PMID: 23603860 Free PMC article.
Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment. Seema Rawal, Fuliang Chu, +14 authors, Sattva S Neelapu. less J Immunol, 2013 May 21; 190(12). PMID: 23686488 Free PMC article.
Host defense and recruitment of Foxp3⁺ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2. Amanda McBride, Jill Konowich, Padmini Salgame. PLoS Pathog, 2013 Jun 21; 9(6). PMID: 23785280 Free PMC article.
CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease. James M Coghill, Kenneth A Fowler, +9 authors, Jonathan S Serody. less Blood, 2013 Jun 27; 122(5). PMID: 23798714 Free PMC article.
Home sweet home: the tumor microenvironment as a haven for regulatory T cells. Beatrice Ondondo, Emma Jones, Andrew Godkin, Awen Gallimore. Front Immunol, 2013 Jul 23; 4. PMID: 23874342 Free PMC article.
Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung. Kari J Dugger, Taylor Chrisman, +5 authors, Lisa Schwiebert. less Brain Behav Immun, 2013 Aug 10; 34. PMID: 23928286 Free PMC article.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski. less Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400 Free PMC article. Highly Cited.
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Pre-existing tolerance shapes the outcome of mucosal allergen sensitization in a murine model of asthma. Timothy J Chapman, Jason A Emo, +2 authors, Sara A Knowlden, Fariba Rezaee, Steve N Georas. less J Immunol, 2013 Sep 17; 191(8). PMID: 24038084 Free PMC article.
Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials. Yohei Mineharu, Maria G Castro, +2 authors, Pedro R Lowenstein, Nobuyuki Sakai, Susumu Miyamoto. less Neurol Med Chir (Tokyo), 2013 Oct 22; 53(11). PMID: 24140772 Free PMC article. Review.
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Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy. Jagadeesh Bayry. Virusdisease, 2014 Jan 16; 25(1). PMID: 24426307 Free PMC article. Review.
Melanoma brain metastasis globally reconfigures chemokine and cytokine profiles in patient cerebrospinal fluid. Edwin Lok, Amy S Chung, Kenneth D Swanson, Eric T Wong. Melanoma Res, 2014 Jan 28; 24(2). PMID: 24463459 Free PMC article.
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Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy. Jonathan M Viney, David P Andrew, +7 authors, James E Pease. less J Immunol, 2014 Feb 25; 192(7). PMID: 24563252 Free PMC article.
Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. Buvana Ravishankar, Rahul Shinde, +8 authors, Tracy L McGaha. less Proc Natl Acad Sci U S A, 2014 Mar 05; 111(11). PMID: 24591636 Free PMC article.
Tracking migration during human T cell development. Joanna Halkias, Heather J Melichar, Kayleigh T Taylor, Ellen A Robey. Cell Mol Life Sci, 2014 Apr 01; 71(16). PMID: 24682469 Review.
Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. Tomoyuki Oshio, Rei Kawashima, +11 authors, Taeko Dohi. less PLoS One, 2014 Apr 10; 9(4). PMID: 24714157 Free PMC article.
Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead. Alma Zernecke. Scientifica (Cairo), 2014 May 13; 2014. PMID: 24818041 Free PMC article. Review.
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Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects. Dimitry A Chistiakov, Igor A Sobenin, Alexander N Orekhov, Yuri V Bobryshev. Front Physiol, 2014 Jun 07; 5. PMID: 24904430 Free PMC article. Review.
Genetic Polymorphisms of CCL22 and CCR4 in Patients with Lung Cancer. Nasrollah Erfani, Ahmadi-Sina Nedaei Ahmadi, Mohammad Ali Ghayumi, Zahra Mojtahedi. Iran J Med Sci, 2014 Jul 18; 39(4). PMID: 25031489 Free PMC article.
Tumor-associated macrophages as major players in the tumor microenvironment. Theerawut Chanmee, Pawared Ontong, Kenjiro Konno, Naoki Itano. Cancers (Basel), 2014 Aug 16; 6(3). PMID: 25125485 Free PMC article. Highly Cited. Review.
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IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis. Ana Claudia Araujo-Pires, Andreia Espindola Vieira, +8 authors, Gustavo Pompermaier Garlet. less J Bone Miner Res, 2014 Sep 30; 30(3). PMID: 25264308 Free PMC article.
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Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor. Robert J Slack, Linda J Russell, +8 authors, David A Hall. less Pharmacol Res Perspect, 2014 Dec 17; 1(2). PMID: 25505571 Free PMC article.
Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing. Zachary Chow, Ashish Banerjee, Michael J Hickey. Immunol Cell Biol, 2015 Jan 15; 93(4). PMID: 25582339 Review.
Macrophage-derived chemokine CCL22 and regulatory T cells in ovarian cancer patients. I Wertel, J Surówka, +5 authors, J Kotarski. less Tumour Biol, 2015 Feb 04; 36(6). PMID: 25647263 Free PMC article.
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Heme oxygenase-1 promotes tumor progression and metastasis of colorectal carcinoma cells by inhibiting antitumor immunity. Geom Seog Seo, Wen-Yi Jiang, +5 authors, Sung Hee Lee. less Oncotarget, 2015 Jun 19; 6(23). PMID: 26087182 Free PMC article.
Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme. Liu Yang, Geng Guo, Xiao-yuan Niu, Jing Liu. Biomed Res Int, 2015 Jul 15; 2015. PMID: 26167495 Free PMC article. Review.
CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis. Raphael Molinaro, Cyntia Pecli, +6 authors, Claudia F Benjamim. less PLoS One, 2015 Jul 22; 10(7). PMID: 26197455 Free PMC article.
TIGIT predominantly regulates the immune response via regulatory T cells. Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson. less J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872 Free PMC article. Highly Cited.
Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. Elisabeth R Mari, Jason N Moore, Guang-Xian Zhang, Abdolmohamad Rostami. Clin Exp Neuroimmunol, 2015 Oct 02; 6(3). PMID: 26425145 Free PMC article.
Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity. Gabriel N Kaufman, Amir H Massoud, +3 authors, Bruce D Mazer. less Front Immunol, 2015 Oct 07; 6. PMID: 26441974 Free PMC article. Review.
Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma. S Haji, J Kiyasu, +10 authors, Y Abe. less Bone Marrow Transplant, 2015 Nov 03; 51(3). PMID: 26524267
New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression. Jacqueline María Valverde-Villegas, Maria Cristina Cotta Matte, Rúbia Marília de Medeiros, José Artur Bogo Chies. J Immunol Res, 2015 Nov 17; 2015. PMID: 26568963 Free PMC article. Review.
The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis. Ning Li, Wei Wei, +6 authors, Jie Han. less Int J Clin Exp Med, 2015 Dec 03; 8(9). PMID: 26628988 Free PMC article.
The Role of Chemokines in Shaping the Balance Between CD4(+) T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases. Nathan Karin, Gizi Wildbaum. Front Immunol, 2015 Dec 10; 6. PMID: 26648938 Free PMC article. Review.
Accumulation Mechanisms of CD4(+)CD25(+)FOXP3(+) Regulatory T Cells in EBV-associated Gastric Carcinoma. Na-na Zhang, Jian-ning Chen, +6 authors, Chun-kui Shao. less Sci Rep, 2015 Dec 18; 5. PMID: 26673957 Free PMC article.
Different maturation cocktails provide dendritic cells with different chemoattractive properties. Chiara Massa, Carolin Thomas, +2 authors, Ena Wang, Francesco Marincola, Barbara Seliger. less J Transl Med, 2015 Dec 24; 13. PMID: 26695182 Free PMC article.
Reciprocity between Regulatory T Cells and Th17 Cells: Relevance to Polarized Immunity in Leprosy. Soumi Sadhu, Binod Kumar Khaitan, +3 authors, Dipendra Kumar Mitra. less PLoS Negl Trop Dis, 2016 Jan 12; 10(1). PMID: 26751584 Free PMC article.
Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α(+) CD103(+) dendritic cells. Shengyu Hao, Xiaolei Han, +4 authors, Chun-Hong Qiu. less Immunology, 2016 Feb 13; 148(2). PMID: 26868141 Free PMC article.
Modulation of chemokines in the tumor microenvironment enhances oncolytic virotherapy for colorectal cancer. Lily Francis, Zong Sheng Guo, +6 authors, David L Bartlett. less Oncotarget, 2016 Mar 10; 7(16). PMID: 26956047 Free PMC article.
Quantitative analysis of the chemotaxis of a green alga, Chlamydomonas reinhardtii, to bicarbonate using diffusion-based microfluidic device. Hong Il Choi, Jaoon Young Hwan Kim, +2 authors, Ho Seok Kwak, Young Joon Sung, Sang Jun Sim. less Biomicrofluidics, 2016 Mar 10; 10(1). PMID: 26958101 Free PMC article.
Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma. Wei Sun, Wei-Jin Li, +5 authors, Wei-Ping Wen. less Oncotarget, 2016 Oct 23; 7(25). PMID: 27177223 Free PMC article.
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Peripheral tolerance can be modified by altering KLF2-regulated Treg migration. Sudheer K Pabbisetty, Whitney Rabacal, +6 authors, Eric Sebzda. less Proc Natl Acad Sci U S A, 2016 Jul 28; 113(32). PMID: 27462110 Free PMC article.
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A rare subset of skin-tropic regulatory T cells expressing Il10/Gzmb inhibits the cutaneous immune response. Ryoyo Ikebuchi, Shunsuke Teraguchi, +5 authors, Michio Tomura. less Sci Rep, 2016 Oct 21; 6. PMID: 27756896 Free PMC article.
Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells. Gabriela Maria Wiedemann, Max Martin Ludwig Knott, +11 authors, David Anz. less Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757295 Free PMC article.
Cytokines and Chemokines in Mycobacterium tuberculosis Infection. Racquel Domingo-Gonzalez, Oliver Prince, Andrea Cooper, Shabaana A Khader. Microbiol Spectr, 2016 Oct 21; 4(5). PMID: 27763255 Free PMC article. Highly Cited. Review.
An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy. Chie Miyabe, Yoshishige Miyabe, +4 authors, Sebastian Unizony. less Ann Rheum Dis, 2016 Dec 09; 76(5). PMID: 27927642 Free PMC article.
CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment. Evelina Martinenaite, Shamaila Munir Ahmad, +7 authors, Mads Hald Andersen. less Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999757 Free PMC article.
The effects of short-term high-fat feeding on exercise capacity: multi-tissue transcriptome changes by RNA sequencing analysis. Ya Xiao, Wanshan Wang, +7 authors, Xiaoshan Zhao. less Lipids Health Dis, 2017 Feb 06; 16(1). PMID: 28153015 Free PMC article.
SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells. Manabu Inoue, Junko Yamada, +4 authors, Naoyuki Chosa. less Mol Med Rep, 2017 Apr 26; 15(6). PMID: 28440453 Free PMC article.
Airway epithelial cells enhance the immunogenicity of human myeloid dendritic cells under steady state. S Agrawal, R Srivastava, +3 authors, A Agrawal. less Clin Exp Immunol, 2017 May 05; 189(3). PMID: 28470729 Free PMC article.
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