Journal Article
. 2001 Sep; 194(6):847-53.
doi: 10.1084/jem.194.6.847.

Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells

A Iellem 1 M Mariani  R Lang  H Recalde  P Panina-Bordignon  F Sinigaglia  D D'Ambrosio  
  • PMID: 11560999
  •     30 References
  •     273 citations


Chemokines dictate regional trafficking of functionally distinct T cell subsets. In rodents and humans, a unique subset of CD4(+)CD25(+) cytotoxic T lymphocyte antigen (CTLA)-4(+) regulatory T cells (Treg) has been proposed to control peripheral tolerance. However, the molecular basis of immune suppression and the trafficking properties of Treg cells are still unknown. Here, we determined the chemotactic response profile and chemokine receptor expression of human blood-borne CD4(+)CD25(+) Treg cells. These Treg cells were found to vigorously respond to several inflammatory and lymphoid chemokines. Treg cells specifically express the chemokine receptors CCR4 and CCR8 and represent a major subset of circulating CD4(+) T cells responding to the chemokines macrophage-derived chemokine (MDC)/CCL22, thymus and activation-regulated chemokine (TARC)/CCL17, I-309/CCL1, and to the virokine vMIP-I (ligands of CCR4 and CCR8). Blood-borne CD4(+) T cells that migrate in response to CCL1 and CCL22 exhibit a reduced alloproliferative response, dependent on the increased frequency of Treg cells in the migrated population. Importantly, mature dendritic cells preferentially attract Treg cells among circulating CD4(+) T cells, by secretion of CCR4 ligands CCL17 and CCL22. Overall, these results suggest that CCR4 and/or CCR8 may guide Treg cells to sites of antigen presentation in secondary lymphoid tissues and inflamed areas to attenuate T cell activation.

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.
F Sallusto, D Lenig, +2 authors, A Lanzavecchia.
Nature, 1999 Oct 28; 401(6754). PMID: 10537110
Highly Cited.
Regulatory T cells and inflammatory bowel disease.
H Groux, F Powrie.
Immunol Today, 1999 Sep 29; 20(10). PMID: 10500290
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
J T Stine, C Wood, +12 authors, D Chantry.
Blood, 2000 Feb 09; 95(4). PMID: 10666184
Chemokines: a new classification system and their role in immunity.
A Zlotnik, O Yoshie.
Immunity, 2000 Mar 14; 12(2). PMID: 10714678
Highly Cited. Review.
Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells.
D D'Ambrosio, A Iellem, +3 authors, F Sinigaglia.
Immunol Today, 2000 Mar 31; 21(4). PMID: 10740239
Inhibition by IL-12 and IFN-alpha of I-309 and macrophage-derived chemokine production upon TCR triggering of human Th1 cells.
A Iellem, L Colantonio, +4 authors, D D'Ambrosio.
Eur J Immunol, 2000 Apr 13; 30(4). PMID: 10760790
The biology of chemokines and their receptors.
D Rossi, A Zlotnik.
Annu Rev Immunol, 2000 Jun 03; 18. PMID: 10837058
Highly Cited. Review.
Regulatory T cells in autoimmmunity*.
E M Shevach.
Annu Rev Immunol, 2000 Jun 03; 18. PMID: 10837065
Highly Cited. Review.
The role of chemokine receptors in primary, effector, and memory immune responses.
F Sallusto, C R Mackay, A Lanzavecchia.
Annu Rev Immunol, 2000 Jun 03; 18. PMID: 10837070
Highly Cited. Review.
Regulatory T cells: key controllers of immunologic self-tolerance.
S Sakaguchi.
Cell, 2000 Jun 13; 101(5). PMID: 10850488
Highly Cited. Review.
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
S Read, V Malmström, F Powrie.
J Exp Med, 2000 Jul 19; 192(2). PMID: 10899916    Free PMC article.
Highly Cited.
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
T Takahashi, T Tagami, +5 authors, S Sakaguchi.
J Exp Med, 2000 Jul 19; 192(2). PMID: 10899917    Free PMC article.
Highly Cited.
Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells.
A Lanzavecchia, F Sallusto.
Science, 2000 Oct 06; 290(5489). PMID: 11021806
Highly Cited. Review.
T cells compete for access to antigen-bearing antigen-presenting cells.
R M Kedl, W A Rees, +4 authors, P Marrack.
J Exp Med, 2000 Oct 18; 192(8). PMID: 11034600    Free PMC article.
Highly Cited.
C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential.
D P Andrew, N Ruffing, +7 authors, L Wu.
J Immunol, 2000 Dec 21; 166(1). PMID: 11123282
Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency.
A L Smith, M E Wikstrom, B Fazekas de St Groth.
Immunity, 2001 Feb 13; 13(6). PMID: 11163194
Chemokines as regulators of T cell differentiation.
S A Luther, J G Cyster.
Nat Immunol, 2001 Mar 29; 2(2). PMID: 11175801
Highly Cited. Review.
Certified professionals: CD4(+)CD25(+) suppressor T cells.
E M Shevach.
J Exp Med, 2001 Jun 08; 193(11). PMID: 11390442    Free PMC article.
Highly Cited.
A novel polypeptide secreted by activated human T lymphocytes.
M D Miller, S Hata, R De Waal Malefyt, M S Krangel.
J Immunol, 1989 Nov 01; 143(9). PMID: 2809212
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.
P S Moore, C Boshoff, R A Weiss, Y Chang.
Science, 1996 Dec 06; 274(5293). PMID: 8939871
Highly Cited.
Regulation of I-309 gene expression in human monocytes by endogenous interleukin-1.
R S Selvan, L J Zhou, M S Krangel.
Eur J Immunol, 1997 Mar 01; 27(3). PMID: 9079810
Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I.
F S Sutterwala, G J Noel, P Salgame, D M Mosser.
J Exp Med, 1998 Jul 07; 188(1). PMID: 9653099    Free PMC article.
Highly Cited.
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.
A M Thornton, E M Shevach.
J Exp Med, 1998 Jul 22; 188(2). PMID: 9670041    Free PMC article.
Highly Cited.
Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.
D D'Ambrosio, A Iellem, +4 authors, F Sinigaglia.
J Immunol, 1998 Nov 20; 161(10). PMID: 9820476
Highly Cited.
The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant.
S Sozzani, W Luini, +12 authors, A Mantovani.
Blood, 1998 Dec 03; 92(11). PMID: 9834206
Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells.
H L Tang, J G Cyster.
Science, 1999 Apr 30; 284(5415). PMID: 10221917
Distinct patterns and kinetics of chemokine production regulate dendritic cell function.
F Sallusto, B Palermo, +7 authors, A Lanzavecchia.
Eur J Immunol, 1999 Jun 08; 29(5). PMID: 10359116
Highly Cited.
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
M J Endres, C G Garlisi, +2 authors, J A Hedrick.
J Exp Med, 1999 Jun 22; 189(12). PMID: 10377196    Free PMC article.
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.
J J Campbell, G Haraldsen, +9 authors, E C Butcher.
Nature, 1999 Aug 31; 400(6746). PMID: 10466728
Highly Cited.
A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum.
H R Lüttichau, J Stine, +4 authors, T W Schwartz.
J Exp Med, 2000 Jan 06; 191(1). PMID: 10620615    Free PMC article.
Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected].
Detlef Dieckmann, Cord Henrik Bruett, +2 authors, Gerold Schuler.
J Exp Med, 2002 Jul 18; 196(2). PMID: 12119349    Free PMC article.
Highly Cited.
Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes.
Francesco Annunziato, Lorenzo Cosmi, +6 authors, Sergio Romagnani.
J Exp Med, 2002 Aug 07; 196(3). PMID: 12163566    Free PMC article.
Highly Cited.
CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages.
Corinna Trebst, Susan M Staugaitis, +11 authors, Richard M Ransohoff.
Am J Pathol, 2003 Jan 28; 162(2). PMID: 12547701    Free PMC article.
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).
Kevan C Herold, Joshua B Burton, +3 authors, Jeffrey A Bluestone.
J Clin Invest, 2003 Feb 06; 111(3). PMID: 12569167    Free PMC article.
Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide.
Iris Caramalho, Thiago Lopes-Carvalho, +3 authors, Jocelyne Demengeot.
J Exp Med, 2003 Feb 20; 197(4). PMID: 12591899    Free PMC article.
Highly Cited.
Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.
Judith Alferink, Ivo Lieberam, +9 authors, Irmgard Förster.
J Exp Med, 2003 Mar 05; 197(5). PMID: 12615900    Free PMC article.
CCR4 is an up-regulated chemokine receptor of peripheral blood memory CD4+ T cells in Crohn's disease.
Y Jo, T Matsumoto, +5 authors, M Iida.
Clin Exp Immunol, 2003 Apr 18; 132(2). PMID: 12699425    Free PMC article.
Chemokines in allergic airway disease.
Clare M Lloyd, Sara M Rankin.
Curr Opin Pharmacol, 2003 Aug 07; 3(4). PMID: 12901955    Free PMC article.
Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus.
Takashi Nakayama, Kunio Hieshima, +4 authors, Osamu Yoshie.
J Virol, 2004 Jan 30; 78(4). PMID: 14747532    Free PMC article.
A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses.
Zoltán Fehérvári, Shimon Sakaguchi.
Arthritis Res Ther, 2004 Feb 26; 6(1). PMID: 14979928    Free PMC article.
CD4+ CD25+ Treg: divide and rule?
Lucy S K Walker.
Immunology, 2004 Mar 19; 111(2). PMID: 15027897    Free PMC article.
A skin-selective homing mechanism for human immune surveillance T cells.
Patrick Schaerli, Lisa Ebert, +4 authors, Bernhard Moser.
J Exp Med, 2004 May 05; 199(9). PMID: 15123746    Free PMC article.
Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
Yang Sen, Hu Chunsong, +7 authors, Tan Jinquan.
Immunology, 2004 May 19; 112(2). PMID: 15147571    Free PMC article.
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells.
Kyra Oswald-Richter, Stacy M Grill, +4 authors, Derya Unutmaz.
PLoS Biol, 2004 Jul 15; 2(7). PMID: 15252446    Free PMC article.
Highly Cited.
Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity.
Susana Mendez, Stacie K Reckling, +2 authors, Yasmine Belkaid.
J Exp Med, 2004 Jul 21; 200(2). PMID: 15263027    Free PMC article.
Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
Chunfeng Qu, Emmerson W Edwards, +13 authors, Gwendalyn J Randolph.
J Exp Med, 2004 Nov 10; 200(10). PMID: 15534368    Free PMC article.
CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1.
Felix N Toka, Susmit Suvas, Barry T Rouse.
J Virol, 2004 Nov 16; 78(23). PMID: 15542660    Free PMC article.
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Hyung W Lim, Peter Hillsamer, Chang H Kim.
J Clin Invest, 2004 Dec 04; 114(11). PMID: 15578096    Free PMC article.
Chemokines: control of primary and memory T-cell traffic.
Patrick Schaerli, Bernhard Moser.
Immunol Res, 2004 Dec 14; 31(1). PMID: 15591623
CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice.
Christine M Freeman, Bo-Chin Chiu, +6 authors, Stephen W Chensue.
J Immunol, 2005 Feb 09; 174(4). PMID: 15699124    Free PMC article.
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor.
Iris Lee, Liqing Wang, +3 authors, Wayne W Hancock.
J Exp Med, 2005 Apr 06; 201(7). PMID: 15809349    Free PMC article.
Highly Cited.
Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells.
Fabien Agenès, Nabil Bosco, +2 authors, Rod Ceredig.
Immunology, 2005 May 12; 115(2). PMID: 15885123    Free PMC article.
Regulatory T cells in rheumatoid arthritis.
Jan Leipe, Alla Skapenko, Peter E Lipsky, Hendrik Schulze-Koops.
Arthritis Res Ther, 2005 May 19; 7(3). PMID: 15899057    Free PMC article.
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia.
Claudia R Ruprecht, Marco Gattorno, +4 authors, Federica Sallusto.
J Exp Med, 2005 Jun 09; 201(11). PMID: 15939793    Free PMC article.
Highly Cited.
Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease.
Christian A Wysocki, Qi Jiang, +5 authors, Jonathan S Serody.
Blood, 2005 Jul 09; 106(9). PMID: 16002422    Free PMC article.
A peripheral circulating compartment of natural naive CD4 Tregs.
Danila Valmori, Andrea Merlo, +2 authors, Maha Ayyoub.
J Clin Invest, 2005 Jul 12; 115(7). PMID: 16007258    Free PMC article.
Highly Cited.
Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa.
Anna Lundgren, Christina Trollmo, +2 authors, B Samuel Lundin.
Infect Immun, 2005 Aug 23; 73(9). PMID: 16113278    Free PMC article.
What does tumour necrosis factor excess do to the immune system long term?
J Clark, P Vagenas, M Panesar, A P Cope.
Ann Rheum Dis, 2005 Oct 22; 64 Suppl 4. PMID: 16239393    Free PMC article.
Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease.
E Gonzalez-Rey, A Fernandez-Martin, A Chorny, M Delgado.
Gut, 2006 Jan 13; 55(6). PMID: 16401687    Free PMC article.
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma.
Zhi-Zhang Yang, Anne J Novak, +2 authors, Stephen M Ansell.
Blood, 2006 Jan 13; 107(9). PMID: 16403912    Free PMC article.
Highly Cited.
Effect of adenovirus-mediated heat shock protein expression and oncolysis in combination with low-dose cyclophosphamide treatment on antitumor immune responses.
Nelson C Di Paolo, Sebastian Tuve, +3 authors, André Lieber.
Cancer Res, 2006 Jan 21; 66(2). PMID: 16424031    Free PMC article.
Regulatory T cell-mediated transplantation tolerance.
Ankit Bharat, Ryan Courtney Fields, T Mohanakumar.
Immunol Res, 2006 Feb 08; 33(3). PMID: 16461998
Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease.
Elena Gonzalez-Rey, Nieves Varela, +3 authors, Mario Delgado.
Proc Natl Acad Sci U S A, 2006 Mar 16; 103(11). PMID: 16537513    Free PMC article.
Regulatory T-cell compartmentalization and trafficking.
Shuang Wei, Ilona Kryczek, Weiping Zou.
Blood, 2006 Mar 16; 108(2). PMID: 16537800    Free PMC article.
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.
Xavier Valencia, Geoffrey Stephens, +3 authors, Peter E Lipsky.
Blood, 2006 Mar 16; 108(1). PMID: 16537805    Free PMC article.
Highly Cited.
Therapeutic effect of vasoactive intestinal peptide on experimental autoimmune encephalomyelitis: down-regulation of inflammatory and autoimmune responses.
Elena Gonzalez-Rey, Amelia Fernandez-Martin, +4 authors, Mario Delgado.
Am J Pathol, 2006 Mar 28; 168(4). PMID: 16565493    Free PMC article.
Mucosal tolerance to E-selectin and response to systemic inflammation.
Kachi Illoh, Catherine Campbell, +5 authors, John Hallenbeck.
J Cereb Blood Flow Metab, 2006 Apr 06; 26(12). PMID: 16596122    Free PMC article.
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence.
Ekaterina Yurchenko, Michael Tritt, +3 authors, Ciriaco A Piccirillo.
J Exp Med, 2006 Oct 04; 203(11). PMID: 17015634    Free PMC article.
Evidence for immunological priming and increased frequency of CD4+ CD25+ cord blood T cells in children born to mothers with type 1 diabetes.
B C Holm, J Svensson, +7 authors, Diabetes Prediction Study in Skåne (DiPiS).
Clin Exp Immunol, 2006 Nov 15; 146(3). PMID: 17100770    Free PMC article.
Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter.
Kate Liddiard, John S Welch, +3 authors, David R Greaves.
BMC Mol Biol, 2006 Dec 01; 7. PMID: 17134490    Free PMC article.
Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study.
Wilco de Jager, Esther P A H Hoppenreijs, +3 authors, Berent J Prakken.
Ann Rheum Dis, 2006 Dec 16; 66(5). PMID: 17170049    Free PMC article.
The chemokine and chemokine receptor superfamilies and their molecular evolution.
Albert Zlotnik, Osamu Yoshie, Hisayuki Nomiyama.
Genome Biol, 2007 Jan 05; 7(12). PMID: 17201934    Free PMC article.
Highly Cited. Review.
Foxp3 occupancy and regulation of key target genes during T-cell stimulation.
Alexander Marson, Karsten Kretschmer, +7 authors, Richard A Young.
Nature, 2007 Jan 24; 445(7130). PMID: 17237765    Free PMC article.
Highly Cited.
Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRL/lpr mice.
Hitoshi Hasegawa, Atsushi Inoue, +3 authors, Masaki Yasukawa.
Arthritis Res Ther, 2007 Feb 08; 9(1). PMID: 17284325    Free PMC article.
Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL.
Dolgor Baatar, Purevdorj Olkhanud, +3 authors, Arya Biragyn.
J Immunol, 2007 Apr 04; 178(8). PMID: 17404270    Free PMC article.
Clinical utilization of chemokines to combat cancer: the double-edged sword.
Chiara Dell'Agnola, Arya Biragyn.
Expert Rev Vaccines, 2007 Apr 06; 6(2). PMID: 17408375    Free PMC article.
CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4+ CD25+ cells.
Richard C Duggleby, Tovah N F Shaw, +2 authors, J S Hill Gaston.
Immunology, 2007 Apr 12; 121(1). PMID: 17425604    Free PMC article.
Periodic accumulation of regulatory T cells in the uterus: preparation for the implantation of a semi-allogeneic fetus?
Marinos Kallikourdis, Alexander G Betz.
PLoS One, 2007 Apr 19; 2(4). PMID: 17440618    Free PMC article.
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
Silvia Deaglio, Karen M Dwyer, +10 authors, Simon C Robson.
J Exp Med, 2007 May 16; 204(6). PMID: 17502665    Free PMC article.
Highly Cited.
CCR4-dependent regulatory T cell function in inflammatory bowel disease.
Qian Yuan, Shannon K Bromley, +4 authors, Andrew D Luster.
J Exp Med, 2007 Jun 06; 204(6). PMID: 17548518    Free PMC article.
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.
Blythe D Sather, Piper Treuting, +4 authors, Daniel J Campbell.
J Exp Med, 2007 Jun 06; 204(6). PMID: 17548521    Free PMC article.
Highly Cited.
Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo.
Martijn A Nolte, Salomé Leibundgut-Landmann, Olivier Joffre, Caetano Reis e Sousa.
J Exp Med, 2007 Jun 06; 204(6). PMID: 17548522    Free PMC article.
CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
Dolgor Baatar, Purevdorj Olkhanud, +2 authors, Arya Biragyn.
J Immunol, 2007 Jul 21; 179(3). PMID: 17641067    Free PMC article.
A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammation.
Matthew A Schaller, Lara E Kallal, Nicholas W Lukacs.
Am J Pathol, 2008 Jan 19; 172(2). PMID: 18202190    Free PMC article.
Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.
Kiran Nistala, Halima Moncrieffe, +3 authors, Lucy R Wedderburn.
Arthritis Rheum, 2008 Mar 04; 58(3). PMID: 18311821    Free PMC article.
Highly Cited.
Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
Elizabeth A Jacobsen, Sergei I Ochkur, +5 authors, James J Lee.
J Exp Med, 2008 Mar 05; 205(3). PMID: 18316417    Free PMC article.
Highly Cited.
Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma.
Khoa D Nguyen, Chris Vanichsarn, Kari C Nadeau.
Eur J Immunol, 2008 Jun 27; 38(7). PMID: 18581330    Free PMC article.
In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.
Jagadeesh Bayry, Elma Z Tchilian, +8 authors, David F Tough.
Proc Natl Acad Sci U S A, 2008 Jul 16; 105(29). PMID: 18621704    Free PMC article.
Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody.
Ravindra Uppaluri, Kathleen C F Sheehan, +6 authors, Robert D Schreiber.
Transplantation, 2008 Jul 16; 86(1). PMID: 18622291    Free PMC article.
CC chemokine receptor 4 modulates Toll-like receptor 9-mediated innate immunity and signaling.
Makoto Ishii, Cory M Hogaboam, +3 authors, Steven L Kunkel.
Eur J Immunol, 2008 Jul 16; 38(8). PMID: 18624303    Free PMC article.
Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation.
Ravikumar Muthuswamy, Julie Urban, +3 authors, Pawel Kalinski.
Cancer Res, 2008 Jul 18; 68(14). PMID: 18632653    Free PMC article.
CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.
Jennifer Kearley, Douglas S Robinson, Clare M Lloyd.
J Allergy Clin Immunol, 2008 Aug 02; 122(3). PMID: 18672278    Free PMC article.
Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome.
A W M Paantjens, J M Kwakkel-van Erp, +4 authors, H G Otten.
Clin Exp Immunol, 2008 Sep 13; 154(2). PMID: 18785972    Free PMC article.
Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?
Arthur A Vandenbark, Halina Offner.
Immunology, 2008 Sep 19; 125(1). PMID: 18798915    Free PMC article.
Role of IFN-gamma and IL-6 in a protective immune response to Yersinia enterocolitica in mice.
Gianluca Matteoli, Edda Fahl, +4 authors, Erwin Bohn.
BMC Microbiol, 2008 Sep 23; 8. PMID: 18803824    Free PMC article.
Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma.
Yi-Ling Chen, Jung-Hua Fang, Ming-Derg Lai, Yan-Shen Shan.
World J Gastroenterol, 2008 Oct 16; 14(38). PMID: 18855977    Free PMC article.
Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.
Joannes F M Jacobs, Albert J Idema, +7 authors, Gosse J Adema.
Neuro Oncol, 2008 Nov 26; 11(4). PMID: 19028999    Free PMC article.
CCR6 regulates the migration of inflammatory and regulatory T cells.
Tomohide Yamazaki, Xuexian O Yang, +12 authors, Chen Dong.
J Immunol, 2008 Dec 04; 181(12). PMID: 19050256    Free PMC article.
Highly Cited.
Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells.
Chi-Mu Chuang, Talia Hoory, +3 authors, Chien-Fu Hung.
Vaccine, 2008 Dec 06; 27(5). PMID: 19056449    Free PMC article.
Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.
Zamaneh Mikhak, Mieko Fukui, +3 authors, Andrew D Luster.
J Allergy Clin Immunol, 2008 Dec 09; 123(1). PMID: 19062085    Free PMC article.
Selective deregulation in chemokine signaling pathways of CD4+CD25(hi)CD127(lo)/(-) regulatory T cells in human allergic asthma.
Khoa D Nguyen, Christopher Vanichsarn, Alison Fohner, Kari C Nadeau.
J Allergy Clin Immunol, 2009 Jan 21; 123(4). PMID: 19152963    Free PMC article.
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.
Marcus C B Tan, Peter S Goedegebuure, +6 authors, David C Linehan.
J Immunol, 2009 Jan 22; 182(3). PMID: 19155524    Free PMC article.
Highly Cited.
Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors.
D Ahern, C M Lloyd, D S Robinson.
Allergy, 2009 Feb 12; 64(8). PMID: 19208087    Free PMC article.
NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment.
Adam W Mailloux, M Rita I Young.
J Immunol, 2009 Feb 24; 182(5). PMID: 19234170    Free PMC article.
Effects of oral commensal and pathogenic bacteria on human dendritic cells.
T Chino, D M Santer, +5 authors, E A Clark.
Oral Microbiol Immunol, 2009 Feb 26; 24(2). PMID: 19239635    Free PMC article.
Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma.
Darryl A Oble, Robert Loewe, Ping Yu, Martin C Mihm.
Cancer Immun, 2009 Apr 03; 9. PMID: 19338264    Free PMC article.
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.
Antonio Di Stasi, Biagio De Angelis, +7 authors, Barbara Savoldo.
Blood, 2009 Apr 21; 113(25). PMID: 19377047    Free PMC article.
Highly Cited.
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood.
Barbara Häringer, Laura Lozza, Bodo Steckel, Jens Geginat.
J Exp Med, 2009 May 06; 206(5). PMID: 19414553    Free PMC article.
Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells.
Purevdorj B Olkhanud, Dolgor Baatar, +7 authors, Arya Biragyn.
Cancer Res, 2009 Jul 02; 69(14). PMID: 19567680    Free PMC article.
Regulatory T cells in asthma.
Clare M Lloyd, Catherine M Hawrylowicz.
Immunity, 2009 Sep 22; 31(3). PMID: 19766086    Free PMC article.
Highly Cited. Review.
Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells?
Hua-xia Yang, Wen Zhang, +5 authors, Xuan Zhang.
Arthritis Res Ther, 2009 Oct 14; 11(5). PMID: 19821980    Free PMC article.
Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.
Matthew N Davies, Jagadeesh Bayry, +7 authors, Darren R Flower.
PLoS One, 2009 Dec 17; 4(11). PMID: 20011659    Free PMC article.
CCL2 blockade augments cancer immunotherapy.
Zvi G Fridlender, George Buchlis, +9 authors, Steven M Albelda.
Cancer Res, 2009 Dec 24; 70(1). PMID: 20028856    Free PMC article.
In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy.
Naozumi Ishimaru, Takeshi Nitta, +4 authors, Yoshio Hayashi.
PLoS One, 2010 Jan 07; 5(1). PMID: 20052419    Free PMC article.
Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells.
L-C Wang, K-H Chu, +2 authors, B-L Chiang.
Clin Exp Immunol, 2010 Jan 12; 160(2). PMID: 20059479    Free PMC article.
CD4+CD25+ regulatory T cells in autoimmune arthritis.
Soyoung Oh, Andrew L Rankin, Andrew J Caton.
Immunol Rev, 2010 Mar 03; 233(1). PMID: 20192995    Free PMC article.
NK depletion results in increased CCL22 secretion and Treg levels in Lewis lung carcinoma via the accumulation of CCL22-secreting CD11b+CD11c+ cells.
Adam W Mailloux, Anna-Maria A Clark, M Rita I Young.
Int J Cancer, 2010 Mar 04; 127(11). PMID: 20198623    Free PMC article.
Inhibitory RNA molecules in immunotherapy for cancer.
Chih-Ping Mao, T-C Wu.
Methods Mol Biol, 2010 Mar 11; 623. PMID: 20217561    Free PMC article.
Increased prevalence of regulatory T cells in the tumor microenvironment and its correlation with TNM stage of hepatocellular carcinoma.
Xiaohong Shen, Na Li, +3 authors, Qiang Li.
J Cancer Res Clin Oncol, 2010 Mar 12; 136(11). PMID: 20221638
Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells.
Susanne Stutte, Thomas Quast, +7 authors, Irmgard Förster.
Proc Natl Acad Sci U S A, 2010 Apr 28; 107(19). PMID: 20421491    Free PMC article.
Role played by CD4+FOXP3+ regulatory T Cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers.
Wei Li, Klara Tenner-Racz, +4 authors, Stanley M Spinola.
J Infect Dis, 2010 May 07; 201(12). PMID: 20443736    Free PMC article.
Expression of CCR8 is increased in asthma.
K Mutalithas, C Guillen, +5 authors, A J Wardlaw.
Clin Exp Allergy, 2010 May 12; 40(8). PMID: 20455898    Free PMC article.
In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients.
Laurence Weiss, Fabrice A Letimier, +6 authors, Yves Levy.
Proc Natl Acad Sci U S A, 2010 May 26; 107(23). PMID: 20498045    Free PMC article.
High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population.
Halima Moncrieffe, Kiran Nistala, +4 authors, Lucy R Wedderburn.
J Immunol, 2010 May 26; 185(1). PMID: 20498355    Free PMC article.
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.
D Lys Guilbride, Pawel Gawlinski, Patrick D L Guilbride.
PLoS One, 2010 May 27; 5(5). PMID: 20502667    Free PMC article.
Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis.
Yong Min Kim, Amanda Munoz, Peter H Hwang, Kari C Nadeau.
Clin Immunol, 2010 Jul 06; 137(1). PMID: 20598643    Free PMC article.
CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.
Kazuya Kitamura, Joshua M Farber, Brian L Kelsall.
J Immunol, 2010 Aug 20; 185(6). PMID: 20720211    Free PMC article.
Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance.
Young-June Kim, Hal E Broxmeyer.
Crit Rev Oncol Hematol, 2010 Aug 24; 79(2). PMID: 20727784    Free PMC article.
Immune evasion by Kaposi's sarcoma-associated herpesvirus.
Hye-Ra Lee, Stacy Lee, +2 authors, Jae U Jung.
Future Microbiol, 2010 Sep 24; 5(9). PMID: 20860481    Free PMC article.
CCL22 regulates experimental autoimmune encephalomyelitis by controlling inflammatory macrophage accumulation and effector function.
Rukiye-Nazan E Dogan, Nancy Long, +4 authors, William J Karpus.
J Leukoc Biol, 2010 Oct 14; 89(1). PMID: 20940325    Free PMC article.
Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.
Adam W Mailloux, M Rita I Young.
Crit Rev Immunol, 2010 Nov 19; 30(5). PMID: 21083525    Free PMC article.
Rabies virus expressing dendritic cell-activating molecules enhances the innate and adaptive immune response to vaccination.
Yongjun Wen, Hualei Wang, +4 authors, Zhen F Fu.
J Virol, 2010 Nov 26; 85(4). PMID: 21106736    Free PMC article.
Vaccination with photodynamic therapy-treated macrophages induces highly suppressive T-regulatory cells.
Oleg E Akilov, Mei X Wu, +4 authors, Tayyaba Hasan.
Photodermatol Photoimmunol Photomed, 2011 Mar 12; 27(2). PMID: 21392113    Free PMC article.
Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
Purevdorj B Olkhanud, Yrina Rochman, +7 authors, Arya Biragyn.
J Immunol, 2011 Apr 15; 186(10). PMID: 21490155    Free PMC article.
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice.
Christian Weber, Svenja Meiler, +20 authors, Alma Zernecke.
J Clin Invest, 2011 Jun 03; 121(7). PMID: 21633167    Free PMC article.
In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-β secreting DCs is crucial for their enrichment and suppression in tumor immunity.
Lin Xu, Wei Xu, Zhenke Wen, Sidong Xiong.
PLoS One, 2011 Jun 10; 6(5). PMID: 21655250    Free PMC article.
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.
Joel Montane, Loraine Bischoff, +7 authors, C Bruce Verchere.
J Clin Invest, 2011 Jul 09; 121(8). PMID: 21737880    Free PMC article.
Lung transplantation affects expression of the chemokine receptor type 4 on specific T cell subsets.
A W M Paantjens, E A van de Graaf, +4 authors, H G Otten.
Clin Exp Immunol, 2011 Sep 14; 166(1). PMID: 21910727    Free PMC article.
Antibody therapy for Adult T-cell leukemia-lymphoma.
Takashi Ishida, Ryuzo Ueda.
Int J Hematol, 2011 Oct 14; 94(5). PMID: 21993874
Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease.
Natsumi Araya, Tomoo Sato, +4 authors, Yoshihisa Yamano.
Viruses, 2011 Oct 14; 3(9). PMID: 21994794    Free PMC article.
Identification of CCL1 as a Gene Differentially Expressed in CD4 T Cells Expressing TIM-3.
Ka Jung Jun, Mi Jin Lee, +3 authors, Sun Park.
Immune Netw, 2011 Nov 01; 11(4). PMID: 22039368    Free PMC article.
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524    Free PMC article.
Regulatory T cells accumulate in the lung allergic inflammation and efficiently suppress T-cell proliferation but not Th2 cytokine production.
Lucas Faustino, Daniel Mucida, +7 authors, Momtchilo Russo.
Clin Dev Immunol, 2011 Dec 14; 2012. PMID: 22162718    Free PMC article.
Failure to recruit anti-inflammatory CD103+ dendritic cells and a diminished CD4+ Foxp3+ regulatory T cell pool in mice that display excessive lung inflammation and increased susceptibility to Mycobacterium tuberculosis.
Chaniya Leepiyasakulchai, Lech Ignatowicz, +2 authors, Markus Sköld.
Infect Immun, 2012 Jan 05; 80(3). PMID: 22215739    Free PMC article.
A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection.
Vincent Pedergnana, Antoine Gessain, +6 authors, Sabine Plancoulaine.
Eur J Hum Genet, 2012 Jan 20; 20(6). PMID: 22258534    Free PMC article.
Accumulation of CCR4⁺CTLA-4 FOXP3⁺CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells.
Helena Svensson, Veronica Olofsson, +5 authors, Marianne Quiding-Järbrink.
PLoS One, 2012 Feb 10; 7(2). PMID: 22319577    Free PMC article.
Interaction of Bifidobacterium bifidum LMG13195 with HT29 cells influences regulatory-T-cell-associated chemokine receptor expression.
Patricia López, Irene González-Rodríguez, +4 authors, Miguel Gueimonde.
Appl Environ Microbiol, 2012 Feb 22; 78(8). PMID: 22344636    Free PMC article.
Immune modulation of inflammatory conditions: regulatory T cells for treatment of GvHD.
Doreen Haase, Mireille Starke, +2 authors, Olaf Rotzschke.
Immunol Res, 2012 Mar 16; 53(1-3). PMID: 22418725
C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.
Catherine Denis, Kathleen Deiteren, +5 authors, Anne-Marie Lambeir.
PLoS One, 2012 Apr 06; 7(3). PMID: 22479563    Free PMC article.
Regulatory T cells in human ovarian cancer.
Dong-Jun Peng, Rebecca Liu, Weiping Zou.
J Oncol, 2012 Apr 07; 2012. PMID: 22481922    Free PMC article.
Targeting chemokine receptor CCR4 in adult T-cell leukemia-lymphoma and other T-cell lymphomas.
Kensei Tobinai, Takeshi Takahashi, Shiro Akinaga.
Curr Hematol Malig Rep, 2012 Apr 28; 7(3). PMID: 22538464    Free PMC article.
T cell homing to epithelial barriers in allergic disease.
Sabina A Islam, Andrew D Luster.
Nat Med, 2012 May 09; 18(5). PMID: 22561834    Free PMC article.
Highly Cited. Review.
The human cutaneous chemokine system.
Michelle L McCully, Bernhard Moser.
Front Immunol, 2011 Jan 01; 2. PMID: 22566823    Free PMC article.
Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF.
Paul Spear, Amorette Barber, Agnieszka Rynda-Apple, Charles L Sentman.
J Immunol, 2012 May 16; 188(12). PMID: 22586039    Free PMC article.
NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells.
Ravikumar Muthuswamy, Erik Berk, +7 authors, Pawel Kalinski.
Cancer Res, 2012 May 18; 72(15). PMID: 22593190    Free PMC article.
Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue.
Christoph Dürr, Marie Follo, +2 authors, Robert Zeiser.
Immunology, 2012 Jun 12; 137(1). PMID: 22681312    Free PMC article.
Regulatory T cells in γ irradiation-induced immune suppression.
Hugh I McFarland, Montserrat Puig, +5 authors, Amy S Rosenberg.
PLoS One, 2012 Jun 23; 7(6). PMID: 22723935    Free PMC article.
Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer.
Helene Pere, Corinne Tanchot, +17 authors, Eric Tartour.
Oncoimmunology, 2012 Jun 28; 1(3). PMID: 22737608    Free PMC article.
Histone methylation analysis and pathway predictions in chickens after MDV infection.
Juan Luo, Apratim Mitra, +6 authors, Jiuzhou Song.
PLoS One, 2012 Aug 01; 7(7). PMID: 22848633    Free PMC article.
Effect of CC chemokine receptor 4 antagonism on the evolution of experimental autoimmune encephalomyelitis.
Shivashankar Othy, Selma Topçu, Srini V Kaveri, Jagadeesh Bayry.
Proc Natl Acad Sci U S A, 2012 Aug 07; 109(37). PMID: 22864916    Free PMC article.
Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC).
Baldev Vasir, Corrine Zarwan, +8 authors, David Avigan.
J Immunother, 2012 Aug 16; 35(7). PMID: 22892452    Free PMC article.
The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers.
Norio Kawamoto, Hidenori Ohnishi, Naomi Kondo, Jack L Strominger.
Int Immunol, 2012 Sep 13; 25(1). PMID: 22968996    Free PMC article.
Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance.
C Tanchot, M Terme, +7 authors, E Tartour.
Cancer Microenviron, 2012 Oct 30; 6(2). PMID: 23104434    Free PMC article.
Chemokines shape the immune responses to tuberculosis.
Samantha R Slight, Shabaana A Khader.
Cytokine Growth Factor Rev, 2012 Nov 22; 24(2). PMID: 23168132    Free PMC article.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation.
Brian P McSharry, Selmir Avdic, Barry Slobedman.
Viruses, 2012 Dec 04; 4(11). PMID: 23202490    Free PMC article.
Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells.
Jens Loebbermann, Lydia Durant, +2 authors, Peter J Openshaw.
Proc Natl Acad Sci U S A, 2013 Feb 06; 110(8). PMID: 23382205    Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.
Mark J Dobrzanski.
Front Oncol, 2013 Mar 28; 3. PMID: 23533029    Free PMC article.
Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs.
Arya Biragyn, Monica Bodogai, +7 authors, Catalina Lee-Chang.
J Immunother, 2013 Apr 23; 36(4). PMID: 23603860    Free PMC article.
Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.
Seema Rawal, Fuliang Chu, +14 authors, Sattva S Neelapu.
J Immunol, 2013 May 21; 190(12). PMID: 23686488    Free PMC article.
Host defense and recruitment of Foxp3⁺ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2.
Amanda McBride, Jill Konowich, Padmini Salgame.
PLoS Pathog, 2013 Jun 21; 9(6). PMID: 23785280    Free PMC article.
CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease.
James M Coghill, Kenneth A Fowler, +9 authors, Jonathan S Serody.
Blood, 2013 Jun 27; 122(5). PMID: 23798714    Free PMC article.
Home sweet home: the tumor microenvironment as a haven for regulatory T cells.
Beatrice Ondondo, Emma Jones, Andrew Godkin, Awen Gallimore.
Front Immunol, 2013 Jul 23; 4. PMID: 23874342    Free PMC article.
Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung.
Kari J Dugger, Taylor Chrisman, +5 authors, Lisa Schwiebert.
Brain Behav Immun, 2013 Aug 10; 34. PMID: 23928286    Free PMC article.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski.
Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400    Free PMC article.
Highly Cited.
STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.
Andrew V Nguyen, Yuan-Yuan Wu, +9 authors, Elaine Y Lin.
Neoplasia, 2013 Sep 13; 15(9). PMID: 24027425    Free PMC article.
Pre-existing tolerance shapes the outcome of mucosal allergen sensitization in a murine model of asthma.
Timothy J Chapman, Jason A Emo, +2 authors, Steve N Georas.
J Immunol, 2013 Sep 17; 191(8). PMID: 24038084    Free PMC article.
Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials.
Yohei Mineharu, Maria G Castro, +2 authors, Susumu Miyamoto.
Neurol Med Chir (Tokyo), 2013 Oct 22; 53(11). PMID: 24140772    Free PMC article.
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.
Francoise Bachelerie, Adit Ben-Baruch, +20 authors, Albert Zlotnik.
Pharmacol Rev, 2013 Nov 13; 66(1). PMID: 24218476    Free PMC article.
Highly Cited. Review.
Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure.
Valerie R Stolberg, Brian Martin, +4 authors, Stephen W Chensue.
Am J Pathol, 2013 Dec 18; 184(2). PMID: 24333113    Free PMC article.
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.
Jagadeesh Bayry.
Virusdisease, 2014 Jan 16; 25(1). PMID: 24426307    Free PMC article.
Melanoma brain metastasis globally reconfigures chemokine and cytokine profiles in patient cerebrospinal fluid.
Edwin Lok, Amy S Chung, Kenneth D Swanson, Eric T Wong.
Melanoma Res, 2014 Jan 28; 24(2). PMID: 24463459    Free PMC article.
Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists.
Laura Ajram, Malcolm Begg, +8 authors, Roberto Solari.
Eur J Pharmacol, 2014 Feb 19; 729. PMID: 24534492    Free PMC article.
Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.
Jonathan M Viney, David P Andrew, +7 authors, James E Pease.
J Immunol, 2014 Feb 25; 192(7). PMID: 24563252    Free PMC article.
Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance.
Buvana Ravishankar, Rahul Shinde, +8 authors, Tracy L McGaha.
Proc Natl Acad Sci U S A, 2014 Mar 05; 111(11). PMID: 24591636    Free PMC article.
Tracking migration during human T cell development.
Joanna Halkias, Heather J Melichar, Kayleigh T Taylor, Ellen A Robey.
Cell Mol Life Sci, 2014 Apr 01; 71(16). PMID: 24682469
Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.
Tomoyuki Oshio, Rei Kawashima, +11 authors, Taeko Dohi.
PLoS One, 2014 Apr 10; 9(4). PMID: 24714157    Free PMC article.
Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead.
Alma Zernecke.
Scientifica (Cairo), 2014 May 13; 2014. PMID: 24818041    Free PMC article.
Regulation of the development of asthmatic inflammation by in situ CD4(+)Foxp3 (+) T cells in a mouse model of late allergic asthma.
Tomomi Nakashima, Toshiharu Hayashi, Takuya Mizuno.
Inflammation, 2014 May 24; 37(5). PMID: 24854160
Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects.
Dimitry A Chistiakov, Igor A Sobenin, Alexander N Orekhov, Yuri V Bobryshev.
Front Physiol, 2014 Jun 07; 5. PMID: 24904430    Free PMC article.
Genetic Polymorphisms of CCL22 and CCR4 in Patients with Lung Cancer.
Nasrollah Erfani, Ahmadi-Sina Nedaei Ahmadi, Mohammad Ali Ghayumi, Zahra Mojtahedi.
Iran J Med Sci, 2014 Jul 18; 39(4). PMID: 25031489    Free PMC article.
Tumor-associated macrophages as major players in the tumor microenvironment.
Theerawut Chanmee, Pawared Ontong, Kenjiro Konno, Naoki Itano.
Cancers (Basel), 2014 Aug 16; 6(3). PMID: 25125485    Free PMC article.
Highly Cited. Review.
Immunological barriers to stem cell therapy in the central nervous system.
Gregory E Tullis, Kathleen Spears, Mark D Kirk.
Stem Cells Int, 2014 Aug 29; 2014. PMID: 25165476    Free PMC article.
IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis.
Ana Claudia Araujo-Pires, Andreia Espindola Vieira, +8 authors, Gustavo Pompermaier Garlet.
J Bone Miner Res, 2014 Sep 30; 30(3). PMID: 25264308    Free PMC article.
Mathematical model of sarcoidosis.
Wenrui Hao, Elliott D Crouser, Avner Friedman.
Proc Natl Acad Sci U S A, 2014 Oct 29; 111(45). PMID: 25349384    Free PMC article.
Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor.
Robert J Slack, Linda J Russell, +8 authors, David A Hall.
Pharmacol Res Perspect, 2014 Dec 17; 1(2). PMID: 25505571    Free PMC article.
Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing.
Zachary Chow, Ashish Banerjee, Michael J Hickey.
Immunol Cell Biol, 2015 Jan 15; 93(4). PMID: 25582339
Macrophage-derived chemokine CCL22 and regulatory T cells in ovarian cancer patients.
I Wertel, J Surówka, +5 authors, J Kotarski.
Tumour Biol, 2015 Feb 04; 36(6). PMID: 25647263    Free PMC article.
Targeting chemokine receptors in disease--a case study of CCR4.
Roberto Solari, James E Pease.
Eur J Pharmacol, 2015 May 20; 763(Pt B). PMID: 25981299    Free PMC article.
Langerhans cell-like dendritic cells stimulated with an adjuvant direct the development of Th1 and Th2 cells in vivo.
K Matsui, A Mori, R Ikeda.
Clin Exp Immunol, 2015 Jun 19; 182(1). PMID: 26084192    Free PMC article.
Heme oxygenase-1 promotes tumor progression and metastasis of colorectal carcinoma cells by inhibiting antitumor immunity.
Geom Seog Seo, Wen-Yi Jiang, +5 authors, Sung Hee Lee.
Oncotarget, 2015 Jun 19; 6(23). PMID: 26087182    Free PMC article.
Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme.
Liu Yang, Geng Guo, Xiao-yuan Niu, Jing Liu.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26167495    Free PMC article.
CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis.
Raphael Molinaro, Cyntia Pecli, +6 authors, Claudia F Benjamim.
PLoS One, 2015 Jul 22; 10(7). PMID: 26197455    Free PMC article.
TIGIT predominantly regulates the immune response via regulatory T cells.
Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson.
J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872    Free PMC article.
Highly Cited.
Mechanisms of immunological tolerance in central nervous system inflammatory demyelination.
Elisabeth R Mari, Jason N Moore, Guang-Xian Zhang, Abdolmohamad Rostami.
Clin Exp Neuroimmunol, 2015 Oct 02; 6(3). PMID: 26425145    Free PMC article.
Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity.
Gabriel N Kaufman, Amir H Massoud, +3 authors, Bruce D Mazer.
Front Immunol, 2015 Oct 07; 6. PMID: 26441974    Free PMC article.
Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma.
S Haji, J Kiyasu, +10 authors, Y Abe.
Bone Marrow Transplant, 2015 Nov 03; 51(3). PMID: 26524267
New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression.
Jacqueline María Valverde-Villegas, Maria Cristina Cotta Matte, Rúbia Marília de Medeiros, José Artur Bogo Chies.
J Immunol Res, 2015 Nov 17; 2015. PMID: 26568963    Free PMC article.
The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis.
Ning Li, Wei Wei, +6 authors, Jie Han.
Int J Clin Exp Med, 2015 Dec 03; 8(9). PMID: 26628988    Free PMC article.
The Role of Chemokines in Shaping the Balance Between CD4(+) T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases.
Nathan Karin, Gizi Wildbaum.
Front Immunol, 2015 Dec 10; 6. PMID: 26648938    Free PMC article.
Accumulation Mechanisms of CD4(+)CD25(+)FOXP3(+) Regulatory T Cells in EBV-associated Gastric Carcinoma.
Na-na Zhang, Jian-ning Chen, +6 authors, Chun-kui Shao.
Sci Rep, 2015 Dec 18; 5. PMID: 26673957    Free PMC article.
Different maturation cocktails provide dendritic cells with different chemoattractive properties.
Chiara Massa, Carolin Thomas, +2 authors, Barbara Seliger.
J Transl Med, 2015 Dec 24; 13. PMID: 26695182    Free PMC article.
Reciprocity between Regulatory T Cells and Th17 Cells: Relevance to Polarized Immunity in Leprosy.
Soumi Sadhu, Binod Kumar Khaitan, +3 authors, Dipendra Kumar Mitra.
PLoS Negl Trop Dis, 2016 Jan 12; 10(1). PMID: 26751584    Free PMC article.
Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α(+) CD103(+) dendritic cells.
Shengyu Hao, Xiaolei Han, +4 authors, Chun-Hong Qiu.
Immunology, 2016 Feb 13; 148(2). PMID: 26868141    Free PMC article.
Modulation of chemokines in the tumor microenvironment enhances oncolytic virotherapy for colorectal cancer.
Lily Francis, Zong Sheng Guo, +6 authors, David L Bartlett.
Oncotarget, 2016 Mar 10; 7(16). PMID: 26956047    Free PMC article.
Quantitative analysis of the chemotaxis of a green alga, Chlamydomonas reinhardtii, to bicarbonate using diffusion-based microfluidic device.
Hong Il Choi, Jaoon Young Hwan Kim, +2 authors, Sang Jun Sim.
Biomicrofluidics, 2016 Mar 10; 10(1). PMID: 26958101    Free PMC article.
Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma.
Wei Sun, Wei-Jin Li, +5 authors, Wei-Ping Wen.
Oncotarget, 2016 Oct 23; 7(25). PMID: 27177223    Free PMC article.
C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer.
Moritz Rapp, Simon Grassmann, +8 authors, Sebastian Kobold.
Oncoimmunology, 2016 May 20; 5(3). PMID: 27195186    Free PMC article.
Peripheral tolerance can be modified by altering KLF2-regulated Treg migration.
Sudheer K Pabbisetty, Whitney Rabacal, +6 authors, Eric Sebzda.
Proc Natl Acad Sci U S A, 2016 Jul 28; 113(32). PMID: 27462110    Free PMC article.
Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.
Adrian Achuthan, Andrew D Cook, +17 authors, John A Hamilton.
J Clin Invest, 2016 Aug 16; 126(9). PMID: 27525438    Free PMC article.
Highly Cited.
A rare subset of skin-tropic regulatory T cells expressing Il10/Gzmb inhibits the cutaneous immune response.
Ryoyo Ikebuchi, Shunsuke Teraguchi, +5 authors, Michio Tomura.
Sci Rep, 2016 Oct 21; 6. PMID: 27756896    Free PMC article.
Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells.
Gabriela Maria Wiedemann, Max Martin Ludwig Knott, +11 authors, David Anz.
Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757295    Free PMC article.
Cytokines and Chemokines in Mycobacterium tuberculosis Infection.
Racquel Domingo-Gonzalez, Oliver Prince, Andrea Cooper, Shabaana A Khader.
Microbiol Spectr, 2016 Oct 21; 4(5). PMID: 27763255    Free PMC article.
Highly Cited. Review.
An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy.
Chie Miyabe, Yoshishige Miyabe, +4 authors, Sebastian Unizony.
Ann Rheum Dis, 2016 Dec 09; 76(5). PMID: 27927642    Free PMC article.
CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment.
Evelina Martinenaite, Shamaila Munir Ahmad, +7 authors, Mads Hald Andersen.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999757    Free PMC article.
The effects of short-term high-fat feeding on exercise capacity: multi-tissue transcriptome changes by RNA sequencing analysis.
Ya Xiao, Wanshan Wang, +7 authors, Xiaoshan Zhao.
Lipids Health Dis, 2017 Feb 06; 16(1). PMID: 28153015    Free PMC article.
SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells.
Manabu Inoue, Junko Yamada, +4 authors, Naoyuki Chosa.
Mol Med Rep, 2017 Apr 26; 15(6). PMID: 28440453    Free PMC article.
Airway epithelial cells enhance the immunogenicity of human myeloid dendritic cells under steady state.
S Agrawal, R Srivastava, +3 authors, A Agrawal.
Clin Exp Immunol, 2017 May 05; 189(3). PMID: 28470729    Free PMC article.
Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis.
Fangli Yang, Danan Wang, +6 authors, Xun Sun.
J Immunol Res, 2017 Jun 07; 2017. PMID: 28584821    Free PMC article.
Regulatory T Cells in Allergy and Asthma.
Elena Martín-Orozco, María Norte-Muñoz, Javier Martínez-García.
Front Pediatr, 2017 Jun 08; 5. PMID: 28589115    Free PMC article.
Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage.
Shuang Geng, Yiwei Zhong, +7 authors, Bin Wang.
Front Immunol, 2017 Jun 24; 8. PMID: 28638384    Free PMC article.
Regulatory T cell frequencies and phenotypes following anti-viral vaccination.
A Charlotte M T de Wolf, Susan van Aalst, +5 authors, Femke Broere.
PLoS One, 2017 Jun 29; 12(6). PMID: 28658271    Free PMC article.
Chemokines encoded by herpesviruses.
Sergio M Pontejo, Philip M Murphy.
J Leukoc Biol, 2017 Aug 30; 102(5). PMID: 28848041    Free PMC article.
Association between a Single Donor TARC/CCL17 Promotor Polymorphism and Obstructive Chronic Lung Allograft Dysfunction after Lung Transplantation.
Kevin Budding, Jessica van Setten, +5 authors, Henderikus G Otten.
Front Immunol, 2017 Sep 22; 8. PMID: 28932229    Free PMC article.
RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo.
Lorenz Fülle, Nancy Steiner, +17 authors, Irmgard Förster.
Mol Ther, 2017 Nov 07; 26(1). PMID: 29103909    Free PMC article.
TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17.
Andrew D Cook, Ming-Chin Lee, +8 authors, John A Hamilton.
JCI Insight, 2018 Mar 23; 3(6). PMID: 29563337    Free PMC article.
CCL17 blockade as a therapy for osteoarthritis pain and disease.
Ming-Chin Lee, Reem Saleh, +4 authors, Andrew D Cook.
Arthritis Res Ther, 2018 Apr 07; 20(1). PMID: 29622035    Free PMC article.
Regulatory T Cells As Potential Targets for HIV Cure Research.
Adam J Kleinman, Ranjit Sivanandham, +2 authors, Cristian Apetrei.
Front Immunol, 2018 May 01; 9. PMID: 29706961    Free PMC article.
Decreased expression of CCL17 in the disrupted nasal polyp epithelium and its regulation by IL-4 and IL-5.
Byoungjae Kim, Hyun-Ji Lee, +9 authors, Tae Hoon Kim.
PLoS One, 2018 May 11; 13(5). PMID: 29746583    Free PMC article.
Complement-Opsonized HIV-1 Alters Cross Talk Between Dendritic Cells and Natural Killer (NK) Cells to Inhibit NK Killing and to Upregulate PD-1, CXCR3, and CCR4 on T Cells.
Rada Ellegård, Mohammad Khalid, +7 authors, Marie Larsson.
Front Immunol, 2018 May 16; 9. PMID: 29760706    Free PMC article.
Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza.
Meghan S Vermillion, Rebecca L Ursin, Sarah E Attreed, Sabra L Klein.
Endocrinology, 2018 Jul 23; 159(9). PMID: 30032246    Free PMC article.
HTLV-1 as a Model for Virus and Host Coordinated Immunoediting.
Talia M Mota, R Brad Jones.
Front Immunol, 2019 Oct 17; 10. PMID: 31616431    Free PMC article.
Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications.
Albert D Donnenberg, James D Luketich, Vera S Donnenberg.
Oncotarget, 2019 Nov 20; 10(60). PMID: 31741710    Free PMC article.
A phase Ib study of utomilumab (PF-05082566) in combination with mogamulizumab in patients with advanced solid tumors.
Ezra E W Cohen, Michael J Pishvaian, +10 authors, Steven F Powell.
J Immunother Cancer, 2019 Dec 06; 7(1). PMID: 31801624    Free PMC article.
CCR4 is rarely expressed in CCR4-mutated T/NK-cell lymphomas other than adult T-cell leukemia/lymphoma.
Yuma Sakamoto, Keiichiro Fujii, +9 authors, Hiroshi Inagaki.
Int J Hematol, 2019 Aug 31; 110(4). PMID: 31468320
GM-CSF in inflammation.
John A Hamilton.
J Exp Med, 2019 Oct 16; 217(1). PMID: 31611249    Free PMC article.
CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis.
Frank Blanco-Pérez, Yoichiro Kato, +12 authors, Masako Toda.
Sci Rep, 2019 Jul 05; 9(1). PMID: 31270368    Free PMC article.
CCR6 defines a subset of activated memory T cells of Th17 potential in immune thrombocytopenia.
M Lyu, Y Li, +7 authors, R Yang.
Clin Exp Immunol, 2018 Nov 08; 195(3). PMID: 30403287    Free PMC article.
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
Shuang Liang, Hsiao-Yen Ma, +17 authors, David A Brenner.
Gastroenterology, 2018 Nov 18; 156(4). PMID: 30445007    Free PMC article.
CCR4-dependent reduction in the number and suppressor function of CD4+Foxp3+ cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis.
Thais B Bertolini, Annie R Piñeros, +4 authors, Vânia L D Bonato.
Cell Death Dis, 2018 Dec 26; 10(1). PMID: 30584243    Free PMC article.
Biology and therapy of primary mediastinal B-cell lymphoma: current status and future directions.
Charlotte Lees, Colm Keane, Maher K Gandhi, Jay Gunawardana.
Br J Haematol, 2019 Feb 12; 185(1). PMID: 30740662    Free PMC article.
Dynamic Expression of Interferon Lambda Regulated Genes in Primary Fibroblasts and Immune Organs of the Chicken.
Mehboob Arslan, Xin Yang, +5 authors, Zhifang Zhang.
Genes (Basel), 2019 Feb 17; 10(2). PMID: 30769908    Free PMC article.
Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response.
Thorsten R Mempel, Francesco Marangoni.
Immunol Rev, 2019 Apr 13; 289(1). PMID: 30977195    Free PMC article.
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity.
Hiroshi Yano, Lawrence P Andrews, Creg J Workman, Dario A A Vignali.
Immunology, 2019 May 16; 157(3). PMID: 31087644    Free PMC article.
Highly Cited. Review.
In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation.
James D Fisher, Wensheng Zhang, +9 authors, Steven R Little.
Sci Adv, 2020 Mar 24; 6(11). PMID: 32201714    Free PMC article.
IFN-γ establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts.
Xin Yang, Mehboob Arslan, +4 authors, Zhifang Zhang.
Acta Biochim Biophys Sin (Shanghai), 2020 Feb 13; 52(3). PMID: 32047904    Free PMC article.
CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.
Moritz Rapp, Maximilian W M Wintergerst, +18 authors, David Anz.
J Exp Med, 2019 Mar 27; 216(5). PMID: 30910796    Free PMC article.
Functional Phenotypic Diversity of Regulatory T Cells Remaining in Inflamed Skin.
Ryoyo Ikebuchi, Maika Fujimoto, +4 authors, Michio Tomura.
Front Immunol, 2019 Jun 04; 10. PMID: 31156643    Free PMC article.
Role of chemokines in rabies pathogenesis and protection.
Xuefeng Niu, Hualei Wang, Zhen F Fu.
Adv Virus Res, 2011 May 24; 79. PMID: 21601043    Free PMC article.
The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer.
Nanna Jørgensen, Gry Persson, Thomas Vauvert F Hviid.
Front Immunol, 2019 May 28; 10. PMID: 31134056    Free PMC article.
A degradatory fate for CCR4 suggests a primary role in Th2 inflammation.
Caroline A Anderson, Pallavi Patel, +3 authors, James E Pease.
J Leukoc Biol, 2020 Feb 14; 107(3). PMID: 32052476    Free PMC article.
Cancer-associated fibroblast-derived interleukin-1β activates protumor C-C motif chemokine ligand 22 signaling in head and neck cancer.
Yu-Hsuan Huang, Che-Ying Chang, +4 authors, Li-Wha Wu.
Cancer Sci, 2019 Jul 22; 110(9). PMID: 31325403    Free PMC article.
Regulation of chemokine expression in the tumor microenvironment.
Anton V Gorbachev, Robert L Fairchild.
Crit Rev Immunol, 2014 Jun 19; 34(2). PMID: 24940911    Free PMC article.
Advances in targeted therapy for malignant lymphoma.
Li Wang, Wei Qin, +5 authors, Wei-Li Zhao.
Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296035    Free PMC article.
Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development.
Rishika Chaudhary, Robert A H Scott, +3 authors, Richard J Blanch.
Transl Vis Sci Technol, 2020 Aug 04; 9(3). PMID: 32742753    Free PMC article.
Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead.
Li Sun, Wenjie Zhang, +7 authors, Yuekang Xu.
Front Immunol, 2020 Aug 28; 11. PMID: 32849502    Free PMC article.
Intestinal CD4 Depletion in HIV / SIV Infection.
Ronald S Veazey.
Curr Immunol Rev, 2019 Aug 23; 15(1). PMID: 31431807    Free PMC article.
Spotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection.
Amanda L Blackmon, Lauren Pinter-Brown.
Drug Des Devel Ther, 2020 Sep 29; 14. PMID: 32982179    Free PMC article.
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands.
Jan Korbecki, Szymon Grochans, +2 authors, Irena Baranowska-Bosiacka.
Int J Mol Sci, 2020 Oct 21; 21(20). PMID: 33076281    Free PMC article.
GM-CSF: A Promising Target in Inflammation and Autoimmunity.
Kevin M C Lee, Adrian A Achuthan, John A Hamilton.
Immunotargets Ther, 2020 Nov 06; 9. PMID: 33150139    Free PMC article.
CCL18 in the Progression of Cancer.
Jan Korbecki, Mateusz Olbromski, Piotr Dzięgiel.
Int J Mol Sci, 2020 Oct 30; 21(21). PMID: 33114763    Free PMC article.
Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma.
Susumu Suzuki, Ayako Masaki, +14 authors, Ryuzo Ueda.
Cancer Sci, 2012 Jun 28; 103(10). PMID: 22735080    Free PMC article.
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma.
Takashi Ishida, Asahi Ito, +6 authors, Ryuzo Ueda.
Cancer Sci, 2013 Jan 31; 104(5). PMID: 23360455    Free PMC article.
Physical constraints on accuracy and persistence during breast cancer cell chemotaxis.
Julien Varennes, Hye-Ran Moon, +2 authors, Bumsoo Han.
PLoS Comput Biol, 2019 Apr 11; 15(4). PMID: 30970018    Free PMC article.
CCR6 blockade on regulatory T cells ameliorates experimental model of multiple sclerosis.
Izabela Jatczak-Pawlik, PaweŁ Wolinski, +2 authors, Andrzej Glabinski.
Cent Eur J Immunol, 2021 Jan 14; 45(3). PMID: 33437177    Free PMC article.
Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment.
Jacinta Jacob, Suchita Nadkarni, +10 authors, Giovanna Lombardi.
Mol Ther Methods Clin Dev, 2021 Jan 30; 20. PMID: 33511246    Free PMC article.
Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae.
Luckshman Ganeshanandan, Michaela Lucas.
Int J Mol Sci, 2021 Jan 28; 22(3). PMID: 33498771    Free PMC article.
The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses.
Aisling B Heeran, Margaret R Dunne, +12 authors, Jacintha O'Sullivan.
Cancers (Basel), 2021 Feb 06; 13(3). PMID: 33540635    Free PMC article.
Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them?
Justine Cinier, Margaux Hubert, +5 authors, Christine Ménétrier-Caux.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33924428    Free PMC article.
STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets.
Dev Bhatt, Boxi Kang, +13 authors, Wenjun Ouyang.
J Exp Med, 2021 Apr 27; 218(6). PMID: 33900375    Free PMC article.
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.
Di Huang, Xueman Chen, +12 authors, Erwei Song.
Nat Immunol, 2021 Jun 19; 22(7). PMID: 34140678
Diagnostic Tools and Biomarkers for Severe Drug Eruptions.
Manabu Yoshioka, Yu Sawada, Motonobu Nakamura.
Int J Mol Sci, 2021 Jul 25; 22(14). PMID: 34299145    Free PMC article.
TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer.
Zhouhong Ge, Maikel P Peppelenbosch, Dave Sprengers, Jaap Kwekkeboom.
Front Immunol, 2021 Aug 10; 12. PMID: 34367161    Free PMC article.
BCL9 regulates CD226 and CD96 checkpoints in CD8+ T cells to improve PD-1 response in cancer.
Mei Feng, Zhongen Wu, +16 authors, Di Zhu.
Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417435    Free PMC article.
Immune cell compartmentalization for brain surveillance and protection.
Tommaso Croese, Giulia Castellani, Michal Schwartz.
Nat Immunol, 2021 Aug 26; 22(9). PMID: 34429552
Immunotherapy of diffuse gliomas: biological background, current status and future developments.
Oliver M Grauer, Pieter Wesseling, Gosse J Adema.
Brain Pathol, 2009 Sep 12; 19(4). PMID: 19744040    Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang.
Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187    Free PMC article.
Proteomic Research on the Antitumor Properties of Medicinal Mushrooms.
Boris Jakopovic, Nada Oršolić, Ivan Jakopovich.
Molecules, 2021 Nov 14; 26(21). PMID: 34771120    Free PMC article.
CCR4 as a Therapeutic Target for Cancer Immunotherapy.
Osamu Yoshie.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771703    Free PMC article.
Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity.
Kazuhiko Matsuo, Osamu Yoshie, Takashi Nakayama.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885241    Free PMC article.
Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models.
Amaia Martinez-Usatorre, Ece Kadioglu, +10 authors, Michele De Palma.
Sci Transl Med, 2021 Aug 13; 13(606). PMID: 34380768    Free PMC article.
So Pathogenic or So What?-A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research.
Adam J Kleinman, Ivona Pandrea, Cristian Apetrei.
Viruses, 2022 Jan 23; 14(1). PMID: 35062339    Free PMC article.
Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons.
Jaqueline Raymondi Silva, Mircea Iftinca, +10 authors, Nader Ghasemlou.
Proc Natl Acad Sci U S A, 2022 Jan 21; 119(4). PMID: 35046040    Free PMC article.
CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2: Characterizing CD4+ T cells in Hodgkin lymphoma.
Johanna Veldman, Jessica Rodrigues Plaça, +9 authors, Arjan Diepstra.
Oncoimmunology, 2022 Feb 04; 11(1). PMID: 35111387    Free PMC article.
Chemokine Receptor-Targeted Therapies: Special Case for CCR8.
Bernhard Moser.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158783    Free PMC article.
Primary Effusion Lymphoma: A Clinicopathologic Perspective.
Diamone A Gathers, Emily Galloway, +3 authors, Javier Munoz.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158997    Free PMC article.
Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2.
Sarah Meister, Laura Hahn, +12 authors, Thomas Kolben.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163802    Free PMC article.
FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
Tania Sarkar, Subhanki Dhar, +10 authors, Gaurisankar Sa.
Front Immunol, 2022 Mar 01; 13. PMID: 35222362    Free PMC article.
Regulatory Cells in Multiple Sclerosis: From Blood to Brain.
Leticia Calahorra, Celia Camacho-Toledano, +2 authors, Diego Clemente.
Biomedicines, 2022 Feb 26; 10(2). PMID: 35203544    Free PMC article.
Key Players of the Immunosuppressive Tumor Microenvironment and Emerging Therapeutic Strategies.
Kevin Park, Mysore S Veena, Daniel Sanghoon Shin.
Front Cell Dev Biol, 2022 Mar 30; 10. PMID: 35345849    Free PMC article.
Targeting Cell-Specific Molecular Mechanisms of Innate Immunity in Atherosclerosis.
M Sauter, H F Langer.
Front Physiol, 2022 Apr 19; 13. PMID: 35432000    Free PMC article.
The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.
Di Wu, Haomin Li, +2 authors, Yi Sun.
Nat Commun, 2022 Jun 01; 13(1). PMID: 35641500