Journal Article
. 2001 Sep; 194(6):847-53.
doi: 10.1084/jem.194.6.847.

Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells

A Iellem 1 M Mariani  R Lang  H Recalde  P Panina-Bordignon  F Sinigaglia  D D'Ambrosio  
Affiliations
  • PMID: 11560999
  •     30 References
  •     273 citations

Abstract

Chemokines dictate regional trafficking of functionally distinct T cell subsets. In rodents and humans, a unique subset of CD4(+)CD25(+) cytotoxic T lymphocyte antigen (CTLA)-4(+) regulatory T cells (Treg) has been proposed to control peripheral tolerance. However, the molecular basis of immune suppression and the trafficking properties of Treg cells are still unknown. Here, we determined the chemotactic response profile and chemokine receptor expression of human blood-borne CD4(+)CD25(+) Treg cells. These Treg cells were found to vigorously respond to several inflammatory and lymphoid chemokines. Treg cells specifically express the chemokine receptors CCR4 and CCR8 and represent a major subset of circulating CD4(+) T cells responding to the chemokines macrophage-derived chemokine (MDC)/CCL22, thymus and activation-regulated chemokine (TARC)/CCL17, I-309/CCL1, and to the virokine vMIP-I (ligands of CCR4 and CCR8). Blood-borne CD4(+) T cells that migrate in response to CCL1 and CCL22 exhibit a reduced alloproliferative response, dependent on the increased frequency of Treg cells in the migrated population. Importantly, mature dendritic cells preferentially attract Treg cells among circulating CD4(+) T cells, by secretion of CCR4 ligands CCL17 and CCL22. Overall, these results suggest that CCR4 and/or CCR8 may guide Treg cells to sites of antigen presentation in secondary lymphoid tissues and inflamed areas to attenuate T cell activation.

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Cancer Immun, 2009 Apr 03; 9. PMID: 19338264    Free PMC article.
Review.
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.
Antonio Di Stasi, Biagio De Angelis, +7 authors, Barbara Savoldo.
Blood, 2009 Apr 21; 113(25). PMID: 19377047    Free PMC article.
Highly Cited.
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood.
Barbara Häringer, Laura Lozza, Bodo Steckel, Jens Geginat.
J Exp Med, 2009 May 06; 206(5). PMID: 19414553    Free PMC article.
Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells.
Purevdorj B Olkhanud, Dolgor Baatar, +7 authors, Arya Biragyn.
Cancer Res, 2009 Jul 02; 69(14). PMID: 19567680    Free PMC article.
Regulatory T cells in asthma.
Clare M Lloyd, Catherine M Hawrylowicz.
Immunity, 2009 Sep 22; 31(3). PMID: 19766086    Free PMC article.
Highly Cited. Review.
Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells?
Hua-xia Yang, Wen Zhang, +5 authors, Xuan Zhang.
Arthritis Res Ther, 2009 Oct 14; 11(5). PMID: 19821980    Free PMC article.
Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.
Matthew N Davies, Jagadeesh Bayry, +7 authors, Darren R Flower.
PLoS One, 2009 Dec 17; 4(11). PMID: 20011659    Free PMC article.
CCL2 blockade augments cancer immunotherapy.
Zvi G Fridlender, George Buchlis, +9 authors, Steven M Albelda.
Cancer Res, 2009 Dec 24; 70(1). PMID: 20028856    Free PMC article.
In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy.
Naozumi Ishimaru, Takeshi Nitta, +4 authors, Yoshio Hayashi.
PLoS One, 2010 Jan 07; 5(1). PMID: 20052419    Free PMC article.
Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells.
L-C Wang, K-H Chu, +2 authors, B-L Chiang.
Clin Exp Immunol, 2010 Jan 12; 160(2). PMID: 20059479    Free PMC article.
CD4+CD25+ regulatory T cells in autoimmune arthritis.
Soyoung Oh, Andrew L Rankin, Andrew J Caton.
Immunol Rev, 2010 Mar 03; 233(1). PMID: 20192995    Free PMC article.
Review.
NK depletion results in increased CCL22 secretion and Treg levels in Lewis lung carcinoma via the accumulation of CCL22-secreting CD11b+CD11c+ cells.
Adam W Mailloux, Anna-Maria A Clark, M Rita I Young.
Int J Cancer, 2010 Mar 04; 127(11). PMID: 20198623    Free PMC article.
Inhibitory RNA molecules in immunotherapy for cancer.
Chih-Ping Mao, T-C Wu.
Methods Mol Biol, 2010 Mar 11; 623. PMID: 20217561    Free PMC article.
Increased prevalence of regulatory T cells in the tumor microenvironment and its correlation with TNM stage of hepatocellular carcinoma.
Xiaohong Shen, Na Li, +3 authors, Qiang Li.
J Cancer Res Clin Oncol, 2010 Mar 12; 136(11). PMID: 20221638
Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells.
Susanne Stutte, Thomas Quast, +7 authors, Irmgard Förster.
Proc Natl Acad Sci U S A, 2010 Apr 28; 107(19). PMID: 20421491    Free PMC article.
Role played by CD4+FOXP3+ regulatory T Cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers.
Wei Li, Klara Tenner-Racz, +4 authors, Stanley M Spinola.
J Infect Dis, 2010 May 07; 201(12). PMID: 20443736    Free PMC article.
Expression of CCR8 is increased in asthma.
K Mutalithas, C Guillen, +5 authors, A J Wardlaw.
Clin Exp Allergy, 2010 May 12; 40(8). PMID: 20455898    Free PMC article.
In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients.
Laurence Weiss, Fabrice A Letimier, +6 authors, Yves Levy.
Proc Natl Acad Sci U S A, 2010 May 26; 107(23). PMID: 20498045    Free PMC article.
High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population.
Halima Moncrieffe, Kiran Nistala, +4 authors, Lucy R Wedderburn.
J Immunol, 2010 May 26; 185(1). PMID: 20498355    Free PMC article.
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.
D Lys Guilbride, Pawel Gawlinski, Patrick D L Guilbride.
PLoS One, 2010 May 27; 5(5). PMID: 20502667    Free PMC article.
Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis.
Yong Min Kim, Amanda Munoz, Peter H Hwang, Kari C Nadeau.
Clin Immunol, 2010 Jul 06; 137(1). PMID: 20598643    Free PMC article.
CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.
Kazuya Kitamura, Joshua M Farber, Brian L Kelsall.
J Immunol, 2010 Aug 20; 185(6). PMID: 20720211    Free PMC article.
Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance.
Young-June Kim, Hal E Broxmeyer.
Crit Rev Oncol Hematol, 2010 Aug 24; 79(2). PMID: 20727784    Free PMC article.
Review.
Immune evasion by Kaposi's sarcoma-associated herpesvirus.
Hye-Ra Lee, Stacy Lee, +2 authors, Jae U Jung.
Future Microbiol, 2010 Sep 24; 5(9). PMID: 20860481    Free PMC article.
Review.
CCL22 regulates experimental autoimmune encephalomyelitis by controlling inflammatory macrophage accumulation and effector function.
Rukiye-Nazan E Dogan, Nancy Long, +4 authors, William J Karpus.
J Leukoc Biol, 2010 Oct 14; 89(1). PMID: 20940325    Free PMC article.
Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression.
Adam W Mailloux, M Rita I Young.
Crit Rev Immunol, 2010 Nov 19; 30(5). PMID: 21083525    Free PMC article.
Review.
Rabies virus expressing dendritic cell-activating molecules enhances the innate and adaptive immune response to vaccination.
Yongjun Wen, Hualei Wang, +4 authors, Zhen F Fu.
J Virol, 2010 Nov 26; 85(4). PMID: 21106736    Free PMC article.
Vaccination with photodynamic therapy-treated macrophages induces highly suppressive T-regulatory cells.
Oleg E Akilov, Mei X Wu, +4 authors, Tayyaba Hasan.
Photodermatol Photoimmunol Photomed, 2011 Mar 12; 27(2). PMID: 21392113    Free PMC article.
Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
Purevdorj B Olkhanud, Yrina Rochman, +7 authors, Arya Biragyn.
J Immunol, 2011 Apr 15; 186(10). PMID: 21490155    Free PMC article.
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice.
Christian Weber, Svenja Meiler, +20 authors, Alma Zernecke.
J Clin Invest, 2011 Jun 03; 121(7). PMID: 21633167    Free PMC article.
In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-β secreting DCs is crucial for their enrichment and suppression in tumor immunity.
Lin Xu, Wei Xu, Zhenke Wen, Sidong Xiong.
PLoS One, 2011 Jun 10; 6(5). PMID: 21655250    Free PMC article.
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.
Joel Montane, Loraine Bischoff, +7 authors, C Bruce Verchere.
J Clin Invest, 2011 Jul 09; 121(8). PMID: 21737880    Free PMC article.
Lung transplantation affects expression of the chemokine receptor type 4 on specific T cell subsets.
A W M Paantjens, E A van de Graaf, +4 authors, H G Otten.
Clin Exp Immunol, 2011 Sep 14; 166(1). PMID: 21910727    Free PMC article.
Antibody therapy for Adult T-cell leukemia-lymphoma.
Takashi Ishida, Ryuzo Ueda.
Int J Hematol, 2011 Oct 14; 94(5). PMID: 21993874
Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease.
Natsumi Araya, Tomoo Sato, +4 authors, Yoshihisa Yamano.
Viruses, 2011 Oct 14; 3(9). PMID: 21994794    Free PMC article.
Review.
Identification of CCL1 as a Gene Differentially Expressed in CD4 T Cells Expressing TIM-3.
Ka Jung Jun, Mi Jin Lee, +3 authors, Sun Park.
Immune Netw, 2011 Nov 01; 11(4). PMID: 22039368    Free PMC article.
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524    Free PMC article.
Review.
Regulatory T cells accumulate in the lung allergic inflammation and efficiently suppress T-cell proliferation but not Th2 cytokine production.
Lucas Faustino, Daniel Mucida, +7 authors, Momtchilo Russo.
Clin Dev Immunol, 2011 Dec 14; 2012. PMID: 22162718    Free PMC article.
Failure to recruit anti-inflammatory CD103+ dendritic cells and a diminished CD4+ Foxp3+ regulatory T cell pool in mice that display excessive lung inflammation and increased susceptibility to Mycobacterium tuberculosis.
Chaniya Leepiyasakulchai, Lech Ignatowicz, +2 authors, Markus Sköld.
Infect Immun, 2012 Jan 05; 80(3). PMID: 22215739    Free PMC article.
A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection.
Vincent Pedergnana, Antoine Gessain, +6 authors, Sabine Plancoulaine.
Eur J Hum Genet, 2012 Jan 20; 20(6). PMID: 22258534    Free PMC article.
Accumulation of CCR4⁺CTLA-4 FOXP3⁺CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells.
Helena Svensson, Veronica Olofsson, +5 authors, Marianne Quiding-Järbrink.
PLoS One, 2012 Feb 10; 7(2). PMID: 22319577    Free PMC article.
Interaction of Bifidobacterium bifidum LMG13195 with HT29 cells influences regulatory-T-cell-associated chemokine receptor expression.
Patricia López, Irene González-Rodríguez, +4 authors, Miguel Gueimonde.
Appl Environ Microbiol, 2012 Feb 22; 78(8). PMID: 22344636    Free PMC article.
Immune modulation of inflammatory conditions: regulatory T cells for treatment of GvHD.
Doreen Haase, Mireille Starke, +2 authors, Olaf Rotzschke.
Immunol Res, 2012 Mar 16; 53(1-3). PMID: 22418725
Review.
C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.
Catherine Denis, Kathleen Deiteren, +5 authors, Anne-Marie Lambeir.
PLoS One, 2012 Apr 06; 7(3). PMID: 22479563    Free PMC article.
Regulatory T cells in human ovarian cancer.
Dong-Jun Peng, Rebecca Liu, Weiping Zou.
J Oncol, 2012 Apr 07; 2012. PMID: 22481922    Free PMC article.
Targeting chemokine receptor CCR4 in adult T-cell leukemia-lymphoma and other T-cell lymphomas.
Kensei Tobinai, Takeshi Takahashi, Shiro Akinaga.
Curr Hematol Malig Rep, 2012 Apr 28; 7(3). PMID: 22538464    Free PMC article.
Review.
T cell homing to epithelial barriers in allergic disease.
Sabina A Islam, Andrew D Luster.
Nat Med, 2012 May 09; 18(5). PMID: 22561834    Free PMC article.
Highly Cited. Review.
The human cutaneous chemokine system.
Michelle L McCully, Bernhard Moser.
Front Immunol, 2011 Jan 01; 2. PMID: 22566823    Free PMC article.
Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF.
Paul Spear, Amorette Barber, Agnieszka Rynda-Apple, Charles L Sentman.
J Immunol, 2012 May 16; 188(12). PMID: 22586039    Free PMC article.
NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells.
Ravikumar Muthuswamy, Erik Berk, +7 authors, Pawel Kalinski.
Cancer Res, 2012 May 18; 72(15). PMID: 22593190    Free PMC article.
Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue.
Christoph Dürr, Marie Follo, +2 authors, Robert Zeiser.
Immunology, 2012 Jun 12; 137(1). PMID: 22681312    Free PMC article.
Regulatory T cells in γ irradiation-induced immune suppression.
Hugh I McFarland, Montserrat Puig, +5 authors, Amy S Rosenberg.
PLoS One, 2012 Jun 23; 7(6). PMID: 22723935    Free PMC article.
Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer.
Helene Pere, Corinne Tanchot, +17 authors, Eric Tartour.
Oncoimmunology, 2012 Jun 28; 1(3). PMID: 22737608    Free PMC article.
Histone methylation analysis and pathway predictions in chickens after MDV infection.
Juan Luo, Apratim Mitra, +6 authors, Jiuzhou Song.
PLoS One, 2012 Aug 01; 7(7). PMID: 22848633    Free PMC article.
Effect of CC chemokine receptor 4 antagonism on the evolution of experimental autoimmune encephalomyelitis.
Shivashankar Othy, Selma Topçu, Srini V Kaveri, Jagadeesh Bayry.
Proc Natl Acad Sci U S A, 2012 Aug 07; 109(37). PMID: 22864916    Free PMC article.
Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC).
Baldev Vasir, Corrine Zarwan, +8 authors, David Avigan.
J Immunother, 2012 Aug 16; 35(7). PMID: 22892452    Free PMC article.
The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers.
Norio Kawamoto, Hidenori Ohnishi, Naomi Kondo, Jack L Strominger.
Int Immunol, 2012 Sep 13; 25(1). PMID: 22968996    Free PMC article.
Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance.
C Tanchot, M Terme, +7 authors, E Tartour.
Cancer Microenviron, 2012 Oct 30; 6(2). PMID: 23104434    Free PMC article.
Chemokines shape the immune responses to tuberculosis.
Samantha R Slight, Shabaana A Khader.
Cytokine Growth Factor Rev, 2012 Nov 22; 24(2). PMID: 23168132    Free PMC article.
Review.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Review.
Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation.
Brian P McSharry, Selmir Avdic, Barry Slobedman.
Viruses, 2012 Dec 04; 4(11). PMID: 23202490    Free PMC article.
Review.
Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells.
Jens Loebbermann, Lydia Durant, +2 authors, Peter J Openshaw.
Proc Natl Acad Sci U S A, 2013 Feb 06; 110(8). PMID: 23382205    Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.
Mark J Dobrzanski.
Front Oncol, 2013 Mar 28; 3. PMID: 23533029    Free PMC article.
Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs.
Arya Biragyn, Monica Bodogai, +7 authors, Catalina Lee-Chang.
J Immunother, 2013 Apr 23; 36(4). PMID: 23603860    Free PMC article.
Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.
Seema Rawal, Fuliang Chu, +14 authors, Sattva S Neelapu.
J Immunol, 2013 May 21; 190(12). PMID: 23686488    Free PMC article.
Host defense and recruitment of Foxp3⁺ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2.
Amanda McBride, Jill Konowich, Padmini Salgame.
PLoS Pathog, 2013 Jun 21; 9(6). PMID: 23785280    Free PMC article.
CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease.
James M Coghill, Kenneth A Fowler, +9 authors, Jonathan S Serody.
Blood, 2013 Jun 27; 122(5). PMID: 23798714    Free PMC article.
Home sweet home: the tumor microenvironment as a haven for regulatory T cells.
Beatrice Ondondo, Emma Jones, Andrew Godkin, Awen Gallimore.
Front Immunol, 2013 Jul 23; 4. PMID: 23874342    Free PMC article.
Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung.
Kari J Dugger, Taylor Chrisman, +5 authors, Lisa Schwiebert.
Brain Behav Immun, 2013 Aug 10; 34. PMID: 23928286    Free PMC article.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski.
Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400    Free PMC article.
Highly Cited.
STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.
Andrew V Nguyen, Yuan-Yuan Wu, +9 authors, Elaine Y Lin.
Neoplasia, 2013 Sep 13; 15(9). PMID: 24027425    Free PMC article.
Pre-existing tolerance shapes the outcome of mucosal allergen sensitization in a murine model of asthma.
Timothy J Chapman, Jason A Emo, +2 authors, Steve N Georas.
J Immunol, 2013 Sep 17; 191(8). PMID: 24038084    Free PMC article.
Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials.
Yohei Mineharu, Maria G Castro, +2 authors, Susumu Miyamoto.
Neurol Med Chir (Tokyo), 2013 Oct 22; 53(11). PMID: 24140772    Free PMC article.
Review.
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.
Francoise Bachelerie, Adit Ben-Baruch, +20 authors, Albert Zlotnik.
Pharmacol Rev, 2013 Nov 13; 66(1). PMID: 24218476    Free PMC article.
Highly Cited. Review.
Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure.
Valerie R Stolberg, Brian Martin, +4 authors, Stephen W Chensue.
Am J Pathol, 2013 Dec 18; 184(2). PMID: 24333113    Free PMC article.
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.
Jagadeesh Bayry.
Virusdisease, 2014 Jan 16; 25(1). PMID: 24426307    Free PMC article.
Review.
Melanoma brain metastasis globally reconfigures chemokine and cytokine profiles in patient cerebrospinal fluid.
Edwin Lok, Amy S Chung, Kenneth D Swanson, Eric T Wong.
Melanoma Res, 2014 Jan 28; 24(2). PMID: 24463459    Free PMC article.
Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists.
Laura Ajram, Malcolm Begg, +8 authors, Roberto Solari.
Eur J Pharmacol, 2014 Feb 19; 729. PMID: 24534492    Free PMC article.
Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.
Jonathan M Viney, David P Andrew, +7 authors, James E Pease.
J Immunol, 2014 Feb 25; 192(7). PMID: 24563252    Free PMC article.
Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance.
Buvana Ravishankar, Rahul Shinde, +8 authors, Tracy L McGaha.
Proc Natl Acad Sci U S A, 2014 Mar 05; 111(11). PMID: 24591636    Free PMC article.
Tracking migration during human T cell development.
Joanna Halkias, Heather J Melichar, Kayleigh T Taylor, Ellen A Robey.
Cell Mol Life Sci, 2014 Apr 01; 71(16). PMID: 24682469
Review.
Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.
Tomoyuki Oshio, Rei Kawashima, +11 authors, Taeko Dohi.
PLoS One, 2014 Apr 10; 9(4). PMID: 24714157    Free PMC article.
Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead.
Alma Zernecke.
Scientifica (Cairo), 2014 May 13; 2014. PMID: 24818041    Free PMC article.
Review.
Regulation of the development of asthmatic inflammation by in situ CD4(+)Foxp3 (+) T cells in a mouse model of late allergic asthma.
Tomomi Nakashima, Toshiharu Hayashi, Takuya Mizuno.
Inflammation, 2014 May 24; 37(5). PMID: 24854160
Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects.
Dimitry A Chistiakov, Igor A Sobenin, Alexander N Orekhov, Yuri V Bobryshev.
Front Physiol, 2014 Jun 07; 5. PMID: 24904430    Free PMC article.
Review.
Genetic Polymorphisms of CCL22 and CCR4 in Patients with Lung Cancer.
Nasrollah Erfani, Ahmadi-Sina Nedaei Ahmadi, Mohammad Ali Ghayumi, Zahra Mojtahedi.
Iran J Med Sci, 2014 Jul 18; 39(4). PMID: 25031489    Free PMC article.
Tumor-associated macrophages as major players in the tumor microenvironment.
Theerawut Chanmee, Pawared Ontong, Kenjiro Konno, Naoki Itano.
Cancers (Basel), 2014 Aug 16; 6(3). PMID: 25125485    Free PMC article.
Highly Cited. Review.
Immunological barriers to stem cell therapy in the central nervous system.
Gregory E Tullis, Kathleen Spears, Mark D Kirk.
Stem Cells Int, 2014 Aug 29; 2014. PMID: 25165476    Free PMC article.
Review.
IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis.
Ana Claudia Araujo-Pires, Andreia Espindola Vieira, +8 authors, Gustavo Pompermaier Garlet.
J Bone Miner Res, 2014 Sep 30; 30(3). PMID: 25264308    Free PMC article.
Mathematical model of sarcoidosis.
Wenrui Hao, Elliott D Crouser, Avner Friedman.
Proc Natl Acad Sci U S A, 2014 Oct 29; 111(45). PMID: 25349384    Free PMC article.
Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor.
Robert J Slack, Linda J Russell, +8 authors, David A Hall.
Pharmacol Res Perspect, 2014 Dec 17; 1(2). PMID: 25505571    Free PMC article.
Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing.
Zachary Chow, Ashish Banerjee, Michael J Hickey.
Immunol Cell Biol, 2015 Jan 15; 93(4). PMID: 25582339
Review.
Macrophage-derived chemokine CCL22 and regulatory T cells in ovarian cancer patients.
I Wertel, J Surówka, +5 authors, J Kotarski.
Tumour Biol, 2015 Feb 04; 36(6). PMID: 25647263    Free PMC article.
Targeting chemokine receptors in disease--a case study of CCR4.
Roberto Solari, James E Pease.
Eur J Pharmacol, 2015 May 20; 763(Pt B). PMID: 25981299    Free PMC article.
Review.
Langerhans cell-like dendritic cells stimulated with an adjuvant direct the development of Th1 and Th2 cells in vivo.
K Matsui, A Mori, R Ikeda.
Clin Exp Immunol, 2015 Jun 19; 182(1). PMID: 26084192    Free PMC article.
Heme oxygenase-1 promotes tumor progression and metastasis of colorectal carcinoma cells by inhibiting antitumor immunity.
Geom Seog Seo, Wen-Yi Jiang, +5 authors, Sung Hee Lee.
Oncotarget, 2015 Jun 19; 6(23). PMID: 26087182    Free PMC article.
Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme.
Liu Yang, Geng Guo, Xiao-yuan Niu, Jing Liu.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26167495    Free PMC article.
Review.
CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis.
Raphael Molinaro, Cyntia Pecli, +6 authors, Claudia F Benjamim.
PLoS One, 2015 Jul 22; 10(7). PMID: 26197455    Free PMC article.
TIGIT predominantly regulates the immune response via regulatory T cells.
Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson.
J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872    Free PMC article.
Highly Cited.
Mechanisms of immunological tolerance in central nervous system inflammatory demyelination.
Elisabeth R Mari, Jason N Moore, Guang-Xian Zhang, Abdolmohamad Rostami.
Clin Exp Neuroimmunol, 2015 Oct 02; 6(3). PMID: 26425145    Free PMC article.
Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity.
Gabriel N Kaufman, Amir H Massoud, +3 authors, Bruce D Mazer.
Front Immunol, 2015 Oct 07; 6. PMID: 26441974    Free PMC article.
Review.
Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma.
S Haji, J Kiyasu, +10 authors, Y Abe.
Bone Marrow Transplant, 2015 Nov 03; 51(3). PMID: 26524267
New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression.
Jacqueline María Valverde-Villegas, Maria Cristina Cotta Matte, Rúbia Marília de Medeiros, José Artur Bogo Chies.
J Immunol Res, 2015 Nov 17; 2015. PMID: 26568963    Free PMC article.
Review.
The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis.
Ning Li, Wei Wei, +6 authors, Jie Han.
Int J Clin Exp Med, 2015 Dec 03; 8(9). PMID: 26628988    Free PMC article.
The Role of Chemokines in Shaping the Balance Between CD4(+) T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases.
Nathan Karin, Gizi Wildbaum.
Front Immunol, 2015 Dec 10; 6. PMID: 26648938    Free PMC article.
Review.
Accumulation Mechanisms of CD4(+)CD25(+)FOXP3(+) Regulatory T Cells in EBV-associated Gastric Carcinoma.
Na-na Zhang, Jian-ning Chen, +6 authors, Chun-kui Shao.
Sci Rep, 2015 Dec 18; 5. PMID: 26673957    Free PMC article.
Different maturation cocktails provide dendritic cells with different chemoattractive properties.
Chiara Massa, Carolin Thomas, +2 authors, Barbara Seliger.
J Transl Med, 2015 Dec 24; 13. PMID: 26695182    Free PMC article.
Reciprocity between Regulatory T Cells and Th17 Cells: Relevance to Polarized Immunity in Leprosy.
Soumi Sadhu, Binod Kumar Khaitan, +3 authors, Dipendra Kumar Mitra.
PLoS Negl Trop Dis, 2016 Jan 12; 10(1). PMID: 26751584    Free PMC article.
Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α(+) CD103(+) dendritic cells.
Shengyu Hao, Xiaolei Han, +4 authors, Chun-Hong Qiu.
Immunology, 2016 Feb 13; 148(2). PMID: 26868141    Free PMC article.
Modulation of chemokines in the tumor microenvironment enhances oncolytic virotherapy for colorectal cancer.
Lily Francis, Zong Sheng Guo, +6 authors, David L Bartlett.
Oncotarget, 2016 Mar 10; 7(16). PMID: 26956047    Free PMC article.
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TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer.
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