Journal Article
. 2002 Jan; 3(2):135-42.
doi: 10.1038/ni759.

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

Jun Shimizu 1 Sayuri Yamazaki  Takeshi Takahashi  Yasumasa Ishida  Shimon Sakaguchi  
Affiliations
  • PMID: 11812990
  •     507 citations

Abstract

CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gene superfamily--is predominantly expressed on CD25(+)CD4(+) T cells and on CD25(+)CD4(+)CD8(-) thymocytes in normal naïve mice. We found that stimulation of GITR abrogated CD25(+)CD4(+) T cell-mediated suppression. In addition, removal of GITR-expressing T cells or administration of a monoclonal antibody to GITR produced organ-specific autoimmune disease in otherwise normal mice. Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease.

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Gurumoorthy Krishnamoorthy, Andreas Holz, Hartmut Wekerle.
J Mol Med (Berl), 2007 Jun 15; 85(11). PMID: 17569024
Review.
OX40 costimulation turns off Foxp3+ Tregs.
Minh Diem Vu, Xiang Xiao, +6 authors, Xian Chang Li.
Blood, 2007 Jun 19; 110(7). PMID: 17575071    Free PMC article.
Highly Cited.
Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice.
Ewa Kozlowska, Marzena Biernacka, Marzena Ciechomska, Nadzieja Drela.
Immunology, 2007 Jul 14; 122(3). PMID: 17627771    Free PMC article.
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Philip O Scumpia, Matthew J Delano, +10 authors, Lyle L Moldawer.
Blood, 2007 Aug 11; 110(10). PMID: 17690255    Free PMC article.
Flt3-ligand plasmid prevents the development of pathophysiological features of chronic asthma in a mouse model.
Jehad H Edwan, Devendra K Agrawal.
Immunol Res, 2007 Aug 19; 37(2). PMID: 17695249
Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.
Sayuri Yamazaki, Anthony J Bonito, +3 authors, Ralph M Steinman.
Blood, 2007 Aug 19; 110(13). PMID: 17699744    Free PMC article.
Transplantation tolerance: lessons from experimental rodent models.
Cherry I Kingsley, Satish N Nadig, Kathryn J Wood.
Transpl Int, 2007 Aug 23; 20(10). PMID: 17711408    Free PMC article.
Review.
Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions.
Onno J de Boer, Jelger J van der Meer, +2 authors, Allard C van der Wal.
PLoS One, 2007 Aug 23; 2(8). PMID: 17712427    Free PMC article.
Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection.
Guoping Peng, Shuping Li, +3 authors, Zhi Chen.
Immunology, 2007 Sep 04; 123(1). PMID: 17764450    Free PMC article.
Regulatory T cells in viral hepatitis.
Eva Billerbeck, Tobias Bottler, Robert Thimme.
World J Gastroenterol, 2007 Sep 11; 13(36). PMID: 17828817    Free PMC article.
Review.
Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40.
Wanda Niedbala, Beilei Cai, +3 authors, Foo Y Liew.
Proc Natl Acad Sci U S A, 2007 Sep 19; 104(39). PMID: 17875988    Free PMC article.
Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression.
Elizabeth H Field, Katarina Kulhankova, Mohamed E Nasr.
Immunol Res, 2007 Oct 06; 39(1-3). PMID: 17917056
High cell surface expression of CD4 allows distinction of CD4(+)CD25(+) antigen-specific effector T cells from CD4(+)CD25(+) regulatory T cells in murine experimental autoimmune encephalomyelitis.
Jinzhu Li, William Ridgway, +2 authors, Michael K Shaw.
J Neuroimmunol, 2007 Oct 09; 192(1-2). PMID: 17920698    Free PMC article.
Regulatory T cells and toll-like receptors: regulating the regulators.
Roger Sutmuller, Anja Garritsen, Gosse J Adema.
Ann Rheum Dis, 2007 Nov 21; 66 Suppl 3. PMID: 17934105    Free PMC article.
Review.
Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease.
Mayumi Kawada, Atsuko Arihiro, Emiko Mizoguchi.
World J Gastroenterol, 2007 Oct 24; 13(42). PMID: 17948932    Free PMC article.
Review.
Increase of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+ CD25+ T lymphocytes.
S Audia, A Nicolas, +12 authors, B Bonnotte.
Clin Exp Immunol, 2007 Oct 25; 150(3). PMID: 17956583    Free PMC article.
The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand.
Hava Ben-David, Amir Sharabi, +2 authors, Edna Mozes.
Proc Natl Acad Sci U S A, 2007 Oct 25; 104(44). PMID: 17956982    Free PMC article.
The association of the activation-inducible tumor necrosis factor receptor and ligand with lumbar disc herniation.
Moon-Soo Park, Hwan-Mo Lee, +6 authors, K Daniel Riew.
Yonsei Med J, 2007 Oct 30; 48(5). PMID: 17963343    Free PMC article.
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells.
Robert Zeiser, Dennis B Leveson-Gower, +5 authors, Robert S Negrin.
Blood, 2007 Oct 31; 111(1). PMID: 17967941    Free PMC article.
Highly Cited.
Regulatory T cells and tumour immunity - observations in mice and men.
Awen Gallimore, Andrew Godkin.
Immunology, 2007 Dec 11; 123(2). PMID: 18067556    Free PMC article.
Review.
Structural basis for ligand-mediated mouse GITR activation.
Zhaocai Zhou, Yukiko Tone, +6 authors, Ramachandran Murali.
Proc Natl Acad Sci U S A, 2008 Jan 08; 105(2). PMID: 18178614    Free PMC article.
Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Kausik Chattopadhyay, Udupi A Ramagopal, +2 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2008 Jan 10; 105(2). PMID: 18182486    Free PMC article.
A two-step process for thymic regulatory T cell development.
Chan-Wang Joaquim Lio, Chyi-Song Hsieh.
Immunity, 2008 Jan 18; 28(1). PMID: 18199417    Free PMC article.
Highly Cited.
T regulatory cells: aid or hindrance in the clearance of disease?
Clint A Coleman, Michaela C Muller-Trutwin, Cristian Apetrei, Ivona Pandrea.
J Cell Mol Med, 2008 Jan 22; 11(6). PMID: 18205702    Free PMC article.
Review.
Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis.
Baoying Liu, Zhuqing Li, +4 authors, Robert B Nussenblatt.
J Biol Chem, 2008 Jan 31; 283(13). PMID: 18230609    Free PMC article.
Comparative methodologies of regulatory T cell depletion in a murine melanoma model.
Norimasa Matsushita, Shari A Pilon-Thomas, Lisa M Martin, Adam I Riker.
J Immunol Methods, 2008 Feb 26; 333(1-2). PMID: 18295790    Free PMC article.
Regulatory T cells and human disease.
Nathalie Cools, Peter Ponsaerts, Viggo F I Van Tendeloo, Zwi N Berneman.
Clin Dev Immunol, 2008 Mar 05; 2007. PMID: 18317534    Free PMC article.
Review.
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection.
Silvia Piconese, Barbara Valzasina, Mario P Colombo.
J Exp Med, 2008 Mar 26; 205(4). PMID: 18362171    Free PMC article.
Highly Cited.
Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states.
Zhaocai Zhou, Xiaomin Song, +6 authors, Mark I Greene.
Proc Natl Acad Sci U S A, 2008 Apr 02; 105(14). PMID: 18378892    Free PMC article.
Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model.
Ana P Castano, Pawel Mroz, Mei X Wu, Michael R Hamblin.
Proc Natl Acad Sci U S A, 2008 Apr 02; 105(14). PMID: 18378905    Free PMC article.
Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1.
Agnieszka Rynda, Massimo Maddaloni, +8 authors, David W Pascual.
J Immunol, 2008 Apr 09; 180(8). PMID: 18390700    Free PMC article.
Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells.
M E Christine Lutsiak, Yutaka Tagaya, +2 authors, Helen Sabzevari.
J Immunol, 2008 Apr 22; 180(9). PMID: 18424706    Free PMC article.
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Mei-Ling Chen, Bo-Shiun Yan, +2 authors, Howard L Weiner.
J Immunol, 2008 May 21; 180(11). PMID: 18490732    Free PMC article.
T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't.
Angela Dolganiuc, Gyongyi Szabo.
J Leukoc Biol, 2008 May 23; 84(3). PMID: 18495782    Free PMC article.
Review.
Toll-like receptor signalling on Tregs: to suppress or not to suppress?
Wendy W C van Maren, Joannes F M Jacobs, +2 authors, Gosse J Adema.
Immunology, 2008 Jun 11; 124(4). PMID: 18540962    Free PMC article.
Review.
CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells.
Trivikram Dasu, Joseph E Qualls, +3 authors, Subbarao Bondada.
Immunol Lett, 2008 Jun 25; 119(1-2). PMID: 18573278    Free PMC article.
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Celine S Lages, Isabelle Suffia, +5 authors, Claire Chougnet.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641321    Free PMC article.
Highly Cited.
Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells.
Keli L Hippen, Paul Harker-Murray, +14 authors, Bruce R Blazar.
Blood, 2008 Jul 23; 112(7). PMID: 18645038    Free PMC article.
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Renata Mazzucchelli, Julie A Hixon, +7 authors, Scott K Durum.
Blood, 2008 Jul 31; 112(8). PMID: 18664628    Free PMC article.
Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Nikki B Marshall, William R Vorachek, +2 authors, Nancy I Kerkvliet.
J Immunol, 2008 Aug 08; 181(4). PMID: 18684927    Free PMC article.
Decreased 4-1BB expression on CD4+CD25 high regulatory T cells in peripheral blood of patients with multiple sclerosis.
G-Z Liu, A C Gomes, +2 authors, P Hjelmstrom.
Clin Exp Immunol, 2008 Aug 30; 154(1). PMID: 18727631    Free PMC article.
Helminth infections and intestinal inflammation.
Li Jian Wang, Yue Cao, Hai Ning Shi.
World J Gastroenterol, 2008 Sep 09; 14(33). PMID: 18777588    Free PMC article.
Review.
Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation.
Zeyu Xiong, Yan Yan, +6 authors, Xiao-Feng Yang.
Atherosclerosis, 2008 Sep 16; 203(2). PMID: 18789801    Free PMC article.
Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant mice.
Sanjay Sharma, Ana Lucia Dominguez, +3 authors, Joseph Lustgarten.
Cancer Res, 2008 Sep 17; 68(18). PMID: 18794141    Free PMC article.
Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus.
Jau-Ling Suen, Hsiao-Ting Li, +2 authors, Jeng-Hsien Yen.
Immunology, 2008 Sep 20; 127(2). PMID: 18800986    Free PMC article.
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood.
Wakae Fujimaki, Nozomu Takahashi, +6 authors, Chikao Morimoto.
Clin Dev Immunol, 2008 Sep 26; 2008. PMID: 18815628    Free PMC article.
Ethylenecarbodiimide-coupled allogeneic antigen presenting cells induce human CD4+ regulatory T cells.
Michael H Albert, Xue-Zhong Yu, Thomas Magg.
Clin Immunol, 2008 Sep 30; 129(3). PMID: 18819845    Free PMC article.
Retroviral immunology: lessons from a mouse model.
Lara Myers, Kim J Hasenkrug.
Immunol Res, 2008 Oct 03; 43(1-3). PMID: 18830572    Free PMC article.
Peripherally induced Treg: mode, stability, and role in specific tolerance.
Irina Apostolou, Panos Verginis, +3 authors, Harald von Boehmer.
J Clin Immunol, 2008 Oct 09; 28(6). PMID: 18841451
Differential requirement of PKC-theta in the development and function of natural regulatory T cells.
Sonal Gupta, Santhakumar Manicassamy, +3 authors, Zuoming Sun.
Mol Immunol, 2008 Oct 10; 46(2). PMID: 18842300    Free PMC article.
Regulatory T cells and their molecular markers in peripheral blood of the patients with systemic lupus erythematosus.
Shaoxian Hu, Wenze Xiao, +3 authors, Min Su.
J Huazhong Univ Sci Technolog Med Sci, 2008 Oct 11; 28(5). PMID: 18846336
T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy.
Roch Houot, Ronald Levy.
Blood, 2008 Oct 23; 113(15). PMID: 18941113    Free PMC article.
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Xin Yu, Kristin Harden, +9 authors, Jane L Grogan.
Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627
Highly Cited.
Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity.
John S Cho, Jeffrey V Hsu, Sherie L Morrison.
Cancer Immunol Immunother, 2008 Nov 20; 58(7). PMID: 19018533    Free PMC article.
Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures.
J M Schartner, A M Singh, +2 authors, C M Seroogy.
Clin Exp Immunol, 2008 Dec 02; 155(2). PMID: 19040605    Free PMC article.
Retinoic acid in the immune system.
Karina Pino-Lagos, Micah J Benson, Randolph J Noelle.
Ann N Y Acad Sci, 2008 Dec 17; 1143. PMID: 19076350    Free PMC article.
Review.
A simple detection method for low-affinity membrane protein interactions by baculoviral display.
Toshiko Sakihama, Takato Sato, +4 authors, Takao Hamakubo.
PLoS One, 2008 Dec 25; 3(12). PMID: 19107192    Free PMC article.
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.
Marcus C B Tan, Peter S Goedegebuure, +6 authors, David C Linehan.
J Immunol, 2009 Jan 22; 182(3). PMID: 19155524    Free PMC article.
Highly Cited.
Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival.
Riccardo D'Elia, Jerzy M Behnke, Janette E Bradley, Kathryn J Else.
J Immunol, 2009 Feb 10; 182(4). PMID: 19201888    Free PMC article.
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.
Debora Franceschini, Marino Paroli, +6 authors, Vincenzo Barnaba.
J Clin Invest, 2009 Feb 21; 119(3). PMID: 19229109    Free PMC article.
Highly Cited.
TNF superfamily: costimulation and clinical applications.
Dass S Vinay, Byoung S Kwon.
Cell Biol Int, 2009 Feb 24; 33(4). PMID: 19230849    Free PMC article.
Review.
Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets.
Maria Nikolova, Jean-Daniel Lelievre, +2 authors, Yves Lévy.
Blood, 2009 Feb 28; 113(19). PMID: 19246340    Free PMC article.
Regulatory T cells overturned: the effectors fight back.
Lucy S K Walker.
Immunology, 2009 Mar 13; 126(4). PMID: 19278420    Free PMC article.
Review.
Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?
Leigh R Guerin, Jelmer R Prins, Sarah A Robertson.
Hum Reprod Update, 2009 Mar 13; 15(5). PMID: 19279047    Free PMC article.
Systematic Review.
Immune rejection of mouse tumors expressing mutated self.
Fei Duan, Yun Lin, +8 authors, Alan N Houghton.
Cancer Res, 2009 Apr 09; 69(8). PMID: 19351857    Free PMC article.
Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients.
Joanna Ashton-Chess, Emilie Dugast, +8 authors, Jean-Paul Soulillou.
J Am Soc Nephrol, 2009 Apr 10; 20(5). PMID: 19357258    Free PMC article.
1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Kausik Chattopadhyay, Udupi A Ramagopal, Stanley G Nathenson, Steven C Almo.
Acta Crystallogr D Biol Crystallogr, 2009 Apr 25; 65(Pt 5). PMID: 19390148    Free PMC article.
Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression.
Chuan Wu, Uwe Rauch, +4 authors, Lydia M Sorokin.
J Immunol, 2009 May 06; 182(10). PMID: 19414805    Free PMC article.
Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia.
Miroslaw J Szczepanski, Marta Szajnik, +6 authors, Michael Boyiadzis.
Clin Cancer Res, 2009 May 07; 15(10). PMID: 19417016    Free PMC article.
Therapeutic immunity by adoptive tumor-primed CD4(+) T-cell transfer in combination with in vivo GITR ligation.
Zuqiang Liu, Shenghe Tian, +2 authors, Zhaoyang You.
Mol Ther, 2009 May 07; 17(7). PMID: 19417739    Free PMC article.
Molecular orchestration of differentiation and function of regulatory T cells.
Li-Fan Lu, Alexander Rudensky.
Genes Dev, 2009 Jun 03; 23(11). PMID: 19487568    Free PMC article.
Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population.
Belén Blanco, José A Pérez-Simón, +10 authors, Jesús F San Miguel.
Haematologica, 2009 Jun 11; 94(7). PMID: 19508976    Free PMC article.
Low molecular weight fraction secreted by SKOV3 cells expands peripheral CD4+CD25+ regulatory T cells and enhances their suppressive capacity.
Xiao Li, Xiaoyun Wan, +2 authors, Xing Xie.
Med Oncol, 2009 Jun 18; 27(3). PMID: 19533418
Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a phase 2 trial.
Nitin Jain, James M Reuben, +7 authors, Jorge Cortes.
Cancer, 2009 Jun 19; 115(17). PMID: 19536894    Free PMC article.
Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.
Caroline E von Allmen, Nicole Schmitz, +8 authors, Martin F Bachmann.
Proc Natl Acad Sci U S A, 2009 Jul 01; 106(28). PMID: 19564598    Free PMC article.
Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.
Ekaterina Breous, Suryanarayan Somanathan, Luk H Vandenberghe, James M Wilson.
Hepatology, 2009 Jul 04; 50(2). PMID: 19575456    Free PMC article.
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
K S Peggs, S A Quezada, J P Allison.
Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765    Free PMC article.
Review.
Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.
Guojiang Chen, Gencheng Han, +6 authors, Yan Li.
PLoS One, 2009 Sep 18; 4(9). PMID: 19759824    Free PMC article.
GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma.
Alexandre C Motta, Joost L M Vissers, +3 authors, Martijn C Nawijn.
Respir Res, 2009 Oct 09; 10. PMID: 19811658    Free PMC article.
Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells?
Hua-xia Yang, Wen Zhang, +5 authors, Xuan Zhang.
Arthritis Res Ther, 2009 Oct 14; 11(5). PMID: 19821980    Free PMC article.
Autoimmune thyroiditis: a model uniquely suited to probe regulatory T cell function.
Yi-Chi M Kong, Gerald P Morris, +3 authors, Chella S David.
J Autoimmun, 2009 Oct 14; 33(3-4). PMID: 19822405    Free PMC article.
Review.
Tregs control the development of symptomatic West Nile virus infection in humans and mice.
Marion C Lanteri, Katie M O'Brien, +17 authors, Philip J Norris.
J Clin Invest, 2009 Oct 27; 119(11). PMID: 19855131    Free PMC article.
Highly Cited.
Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis.
Graham P Wright, Clare A Notley, +5 authors, Hans J Stauss.
Proc Natl Acad Sci U S A, 2009 Nov 04; 106(45). PMID: 19884493    Free PMC article.
GITR Blockade Facilitates Treg Mediated Allograft Survival.
Samsher B Sonawane, James I Kim, +9 authors, James F Markmann.
Transplantation, 2009 Nov 26; 88(10). PMID: 19935370    Free PMC article.
Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.
Sylvaine You, Lynn Poulton, +8 authors, Lucienne Chatenoud.
PLoS One, 2009 Nov 26; 4(11). PMID: 19936238    Free PMC article.
Integrating costimulatory agonists to optimize immune-based cancer therapies.
Angela D Pardee, Amy K Wesa, Walter J Storkus.
Immunotherapy, 2010 Jan 05; 1(2). PMID: 20046961    Free PMC article.
Review.
Effects of nilotinib on regulatory T cells: the dose matters.
Fei Fei, Yingzhe Yu, +6 authors, Michael Schmitt.
Mol Cancer, 2010 Feb 02; 9. PMID: 20113470    Free PMC article.
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
Shoba Amarnath, Carliann M Costanzo, +9 authors, Daniel H Fowler.
PLoS Biol, 2010 Feb 04; 8(2). PMID: 20126379    Free PMC article.
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.
Gongxian Liao, Sushrusha Nayak, +7 authors, Cox Terhorst.
Int Immunol, 2010 Feb 09; 22(4). PMID: 20139172    Free PMC article.
Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival.
James I Kim, Samsher B Sonawane, +10 authors, James F Markmann.
Eur J Immunol, 2010 Feb 12; 40(5). PMID: 20148423    Free PMC article.
NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction.
Jeffrey S Miller, Edus H Warren, +9 authors, J H Frederik Falkenburg.
Biol Blood Marrow Transplant, 2010 Feb 16; 16(5). PMID: 20152921    Free PMC article.
Association of two clones allows for optimal detection of human FOXP3.
Pietro Presicce, Maria E Moreno-Fernandez, +2 authors, Claire A Chougnet.
Cytometry A, 2010 Feb 18; 77(6). PMID: 20162533    Free PMC article.
Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases.
Franco Pandolfi, Rossella Cianci, +2 authors, Giovanni Cammarota.
Mediators Inflamm, 2010 Feb 20; 2009. PMID: 20169125    Free PMC article.
Review.
CD4+CD25+ regulatory T cells in autoimmune arthritis.
Soyoung Oh, Andrew L Rankin, Andrew J Caton.
Immunol Rev, 2010 Mar 03; 233(1). PMID: 20192995    Free PMC article.
Review.
Enhancement of humoral and cellular immunity with an anti-glucocorticoid-induced tumour necrosis factor receptor monoclonal antibody.
Jose F Ponte, Paul Ponath, +7 authors, Michael Rosenzweig.
Immunology, 2010 Mar 06; 130(2). PMID: 20201988    Free PMC article.
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.
Lilian Lacerda Bueno, Cristiane Guimarães Morais, +6 authors, Erika Martins Braga.
PLoS One, 2010 Mar 13; 5(3). PMID: 20224778    Free PMC article.
An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand.
Dawei Cui, Shengjun Wang, +8 authors, Huaxi Xu.
Cell Mol Immunol, 2010 Mar 17; 7(4). PMID: 20228835    Free PMC article.
A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma.
Marie-Denise Poirier, Houda Haban, Abdeljabar El Andaloussi.
J Oncol, 2009 Jan 01; 2009. PMID: 20339520    Free PMC article.
Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset.
Roopali Gandhi, Mauricio F Farez, +3 authors, Howard L Weiner.
J Immunol, 2010 Apr 07; 184(9). PMID: 20368276    Free PMC article.
OX40 is required for regulatory T cell-mediated control of colitis.
Thibault Griseri, Mark Asquith, Claire Thompson, Fiona Powrie.
J Exp Med, 2010 Apr 07; 207(4). PMID: 20368580    Free PMC article.
Immunity, thyroid function and pregnancy: molecular mechanisms.
Anthony P Weetman.
Nat Rev Endocrinol, 2010 Apr 28; 6(6). PMID: 20421883
Review.
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.
Adam D Cohen, David A Schaer, +10 authors, Jedd D Wolchok.
PLoS One, 2010 May 11; 5(5). PMID: 20454651    Free PMC article.
Highly Cited.
Directing dendritic cell immunotherapy towards successful cancer treatment.
Rachel Lubong Sabado, Nina Bhardwaj.
Immunotherapy, 2010 May 18; 2(1). PMID: 20473346    Free PMC article.
Review.
Natural Foxp3(+) regulatory T cells inhibit Th2 polarization but are biased toward suppression of Th17-driven lung inflammation.
Teri Girtsman, Zeina Jaffar, +2 authors, Kevan Roberts.
J Leukoc Biol, 2010 May 25; 88(3). PMID: 20495073    Free PMC article.
Modulation of CTLA-4 and GITR for cancer immunotherapy.
Francesca Avogadri, Jianda Yuan, +2 authors, Jedd D Wolchok.
Curr Top Microbiol Immunol, 2010 Jun 22; 344. PMID: 20563707    Free PMC article.
Review.
Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells.
Brian G Engelhardt, James E Crowe.
Curr Top Microbiol Immunol, 2010 Jun 22; 341. PMID: 20563712    Free PMC article.
Trends in cancer immunotherapy.
Joseph F Murphy.
Clin Med Insights Oncol, 2010 Aug 13; 4. PMID: 20703326    Free PMC article.
Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment.
Paolo A Ascierto, Maria Napolitano, +14 authors, Nicola Mozzillo.
J Transl Med, 2010 Aug 18; 8. PMID: 20712892    Free PMC article.
Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection.
Tanner M Johanns, James M Ertelt, Jared H Rowe, Sing Sing Way.
PLoS Pathog, 2010 Aug 18; 6(8). PMID: 20714351    Free PMC article.
Tolerance: an overview and perspectives.
Herman Waldmann.
Nat Rev Nephrol, 2010 Aug 19; 6(10). PMID: 20717099
Review.
Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance.
Young-June Kim, Hal E Broxmeyer.
Crit Rev Oncol Hematol, 2010 Aug 24; 79(2). PMID: 20727784    Free PMC article.
Review.
Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
Zohar Ochanuna, Anat Geiger-Maor, +3 authors, Jacob Rachmilewitz.
PLoS One, 2010 Oct 05; 5(9). PMID: 20886106    Free PMC article.
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.
Taylor H Schreiber, Dietlinde Wolf, +6 authors, Eckhard R Podack.
J Clin Invest, 2010 Oct 05; 120(10). PMID: 20890040    Free PMC article.
Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation.
Theresa Placke, Hans-Georg Kopp, Helmut Rainer Salih.
Clin Dev Immunol, 2010 Oct 12; 2010. PMID: 20936139    Free PMC article.
Review.
GITR expression on T-cell receptor-stimulated human CD8 T cell in a JNK-dependent pathway.
Subhasis Chattopadhyay, Nitya G Chakraborty.
Indian J Hum Genet, 2009 Sep 01; 15(3). PMID: 21088717    Free PMC article.
The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice.
M Galuppo, G Nocentini, +8 authors, S Cuzzocrea.
Br J Pharmacol, 2010 Nov 26; 162(5). PMID: 21091650    Free PMC article.
Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens.
Anik L Côté, Peisheng Zhang, +5 authors, Mary Jo Turk.
J Immunol, 2010 Nov 26; 186(1). PMID: 21106849    Free PMC article.
The role of natural regulatory T cells in infection.
Ana M Sanchez, Yiping Yang.
Immunol Res, 2010 Dec 01; 49(1-3). PMID: 21116872    Free PMC article.
Review.
Role of CD4CD25FOXP3 Regulatory T Cells in Psoriasis.
Woo-Jin Yun, Deok-Woo Lee, +8 authors, Jee-Ho Choi.
Ann Dermatol, 2010 Dec 18; 22(4). PMID: 21165208    Free PMC article.
Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points.
Kirsten K Dietze, Gennadiy Zelinskyy, +6 authors, Ulf Dittmer.
Proc Natl Acad Sci U S A, 2011 Jan 26; 108(6). PMID: 21262821    Free PMC article.
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
Gargi Dasgupta, Aziz Alami Chentoufi, +7 authors, Lbachir BenMohamed.
Invest Ophthalmol Vis Sci, 2011 Jan 29; 52(6). PMID: 21273544    Free PMC article.
Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer.
Brad E Hoffman, Ashley T Martino, +4 authors, Roland W Herzog.
Mol Ther, 2011 Mar 10; 19(7). PMID: 21386826    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Treatment with IP-10 induces host-protective immune response by regulating the T regulatory cell functioning in Leishmania donovani-infected mice.
Gaurav Gupta, Saikat Majumdar, +4 authors, Subrata Majumdar.
Med Microbiol Immunol, 2011 May 03; 200(4). PMID: 21533785
Association of functional GITR gene polymorphisms related to expression of glucocorticoid-induced tumour necrosis factor-receptor (GITR) molecules with prognosis of autoimmune thyroid disease.
R Tomizawa, M Watanabe, +5 authors, Y Iwatani.
Clin Exp Immunol, 2011 May 20; 165(2). PMID: 21592113    Free PMC article.
Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).
Derek V Chan, Ally-Khan Somani, +7 authors, Thomas S McCormick.
BMC Biochem, 2011 May 28; 12. PMID: 21615933    Free PMC article.
Costimulatory pathways in transplantation.
Nina Pilat, Mohamed H Sayegh, Thomas Wekerle.
Semin Immunol, 2011 May 28; 23(4). PMID: 21616680    Free PMC article.
T regulatory cells participate in the control of germinal centre reactions.
Carla-Maria Alexander, Lorraine T Tygrett, +3 authors, Thomas J Waldschmidt.
Immunology, 2011 Jun 04; 133(4). PMID: 21635248    Free PMC article.
Type I diabetes-associated tolerogenic properties of interleukin-2.
Aziz Alami Chentoufi, Simon Gaudreau, +3 authors, Geyhad Elghazali.
Clin Dev Immunol, 2011 Jun 08; 2011. PMID: 21647403    Free PMC article.
Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth.
Soraya Zorro Manrique, Maria Adelaida Duque Correa, +6 authors, Joseph Lustgarten.
J Exp Med, 2011 Jun 15; 208(7). PMID: 21670203    Free PMC article.
Obstructive jaundice expands intrahepatic regulatory T cells, which impair liver T lymphocyte function but modulate liver cholestasis and fibrosis.
Steven C Katz, Kristin Ryan, +9 authors, Ronald P Dematteo.
J Immunol, 2011 Jun 24; 187(3). PMID: 21697460    Free PMC article.
Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo.
Nienke van der Werf, Stephen A Redpath, +5 authors, Matthew D Taylor.
J Immunol, 2011 Jun 28; 187(3). PMID: 21705620    Free PMC article.
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Lei Tian, John A Altin, +5 authors, Adrian Liston.
Blood, 2011 Jul 01; 118(7). PMID: 21715314    Free PMC article.
Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients.
Laure Vallotton, Karine Hadaya, +7 authors, Manuel Pascual.
Clin J Am Soc Nephrol, 2011 Jul 16; 6(8). PMID: 21757642    Free PMC article.
A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.
Kathryn W Juchem, Britt E Anderson, +6 authors, Mark J Shlomchik.
Blood, 2011 Jul 20; 118(23). PMID: 21768295    Free PMC article.
Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.
Jonas Persson, Ines Beyer, +4 authors, André Lieber.
PLoS One, 2011 Jul 23; 6(7). PMID: 21779410    Free PMC article.
Regulatory T cell: a protection for tumour cells.
Yi Wang, Yushui Ma, +4 authors, Xizhong Shen.
J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966    Free PMC article.
Review.
Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors.
Derek A Wainwright, Sadhak Sengupta, Yu Han, Maciej S Lesniak.
Neuro Oncol, 2011 Sep 13; 13(12). PMID: 21908444    Free PMC article.
Molecular and functional heterogeneity of T regulatory cells.
Lequn Li, Vassiliki A Boussiotis.
Clin Immunol, 2011 Sep 29; 141(3). PMID: 21945485    Free PMC article.
Review.
Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.
Yu Zhen, Lina Sun, +7 authors, Yong Zhao.
Cell Mol Immunol, 2011 Oct 11; 9(1). PMID: 21983870    Free PMC article.
Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.
Scott K Pruitt, David Boczkowski, +5 authors, Smita Nair.
Eur J Immunol, 2011 Oct 27; 41(12). PMID: 22028176    Free PMC article.
Pharmacological modulation of GITRL/GITR system: therapeutic perspectives.
Giuseppe Nocentini, Simona Ronchetti, Maria Grazia Petrillo, Carlo Riccardi.
Br J Pharmacol, 2011 Oct 28; 165(7). PMID: 22029729    Free PMC article.
Review.
Induction of contact-dependent CD8(+) regulatory T cells through stimulation with staphylococcal and streptococcal superantigens.
Amanda L Taylor, Elizabeth L A Cross, Martin J Llewelyn.
Immunology, 2011 Nov 03; 135(2). PMID: 22043981    Free PMC article.
Identification of a unique double-negative regulatory T-cell population.
Byung O Lee, Joyce E Jones, +5 authors, David R Milich.
Immunology, 2011 Nov 03; 134(4). PMID: 22044159    Free PMC article.
Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke.
M Takata, T Nakagomi, +7 authors, T Matsuyama.
Cell Death Differ, 2011 Nov 05; 19(5). PMID: 22052192    Free PMC article.
Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells during human hookworm infection modulates antigen-mediated lymphocyte proliferation.
Natasha Delaqua Ricci, Jacqueline Araújo Fiúza, +10 authors, Ricardo Toshio Fujiwara.
PLoS Negl Trop Dis, 2011 Nov 17; 5(11). PMID: 22087344    Free PMC article.
Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice.
Gongxian Liao, Cynthia Detre, +5 authors, Cox Terhorst.
Gastroenterology, 2011 Dec 14; 142(3). PMID: 22155173    Free PMC article.
Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease.
Rudi Alberts, Hairong Chen, +6 authors, Klaus Schughart.
BMC Genomics, 2011 Dec 21; 12. PMID: 22182475    Free PMC article.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Oana Draghiciu, Hans W Nijman, Toos Daemen.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971    Free PMC article.
Review.
Regulatory T cells: mechanisms of differentiation and function.
Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781    Free PMC article.
Highly Cited. Review.
Sex-hormone receptors pattern on regulatory T-cells: clinical implications for multiple sclerosis.
Carol Aristimuño, Roseta Teijeiro, +7 authors, Silvia Sánchez-Ramón.
Clin Exp Med, 2012 Jan 10; 12(4). PMID: 22227825
Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
Yong Chen, Shudan Shen, +2 authors, Xiao-Ping Zhong.
J Immunol, 2012 Jan 11; 188(4). PMID: 22231701    Free PMC article.
The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis.
Ricardo F Antunes, Juan Carlos Kaski, Ingrid E Dumitriu.
J Biomed Biotechnol, 2012 Jan 12; 2012. PMID: 22235167    Free PMC article.
Review.
Modulation of GITR for cancer immunotherapy.
David A Schaer, Judith T Murphy, Jedd D Wolchok.
Curr Opin Immunol, 2012 Jan 17; 24(2). PMID: 22245556    Free PMC article.
Review.
Regulatory immunotherapy in bone marrow transplantation.
Vanessa Morales-Tirado, Wioleta Luszczek, Marié van der Merwe, Asha Pillai.
ScientificWorldJournal, 2012 Jan 21; 11. PMID: 22262950    Free PMC article.
Review.
Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR.
Lenka Sinik Teodorovic, Carlo Riccardi, Raul M Torres, Roberta Pelanda.
PLoS One, 2012 Feb 14; 7(2). PMID: 22328941    Free PMC article.
Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium.
Kirsten E Lyke, Abdoulaye Dabo, +6 authors, Marcelo B Sztein.
PLoS One, 2012 Feb 22; 7(2). PMID: 22348117    Free PMC article.
Induction of GITRL expression in human keratinocytes by Th2 cytokines and TNF-α: implications for atopic dermatitis.
A M Byrne, E Goleva, +3 authors, D Y M Leung.
Clin Exp Allergy, 2012 Mar 16; 42(4). PMID: 22417213    Free PMC article.
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
Anthony Joetham, Hiroshi Ohnishi, +5 authors, Erwin W Gelfand.
J Biol Chem, 2012 Mar 31; 287(21). PMID: 22461627    Free PMC article.
The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells.
Bong Ihn Koh, Yibin Kang.
EMBO Rep, 2012 Apr 05; 13(5). PMID: 22473297    Free PMC article.
Review.
Regulatory T cells in human ovarian cancer.
Dong-Jun Peng, Rebecca Liu, Weiping Zou.
J Oncol, 2012 Apr 07; 2012. PMID: 22481922    Free PMC article.
T-regulatory cells: key players in tumor immune escape and angiogenesis.
Andrea Facciabene, Gregory T Motz, George Coukos.
Cancer Res, 2012 May 03; 72(9). PMID: 22549946    Free PMC article.
Highly Cited. Review.
The role of CD103⁺ dendritic cells in the intestinal mucosal immune system.
Darren Thomas Ruane, Ed C Lavelle.
Front Immunol, 2011 Jan 01; 2. PMID: 22566815    Free PMC article.
On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation.
Anja U Engela, Carla C Baan, +2 authors, Martin J Hoogduijn.
Front Immunol, 2012 May 26; 3. PMID: 22629256    Free PMC article.
CD8+ T cells: GITR matters.
Simona Ronchetti, Giuseppe Nocentini, Maria Grazia Petrillo, Carlo Riccardi.
ScientificWorldJournal, 2012 Jun 02; 2012. PMID: 22654588    Free PMC article.
Review.
Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation?
Francisco Salcido-Ochoa, Nurhashikin Yusof, +3 authors, Olaf Rotzschke.
J Transplant, 2012 Jun 13; 2012. PMID: 22690325    Free PMC article.
A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells.
Yi Tian, Guoqiang Wu, +11 authors, Bing Ni.
BMC Immunol, 2012 Jun 15; 13. PMID: 22694797    Free PMC article.
Reduction of circulating regulatory T cells by intravenous high-dose interferon alfa-2b treatment in melanoma patients.
Nicola Mozzillo, Paolo Ascierto.
Clin Exp Metastasis, 2012 Jul 04; 29(7). PMID: 22752507
CD4(+)CD25 (+)CD127 (low/-) T cells: a more specific Treg population in human peripheral blood.
Ning Yu, Xiaomei Li, +6 authors, Xiangpei Li.
Inflammation, 2012 Jul 04; 35(6). PMID: 22752562
The role of regulatory T cells in the pathogenesis of sepsis and its clinical implication.
Li-Na Jiang, Yong-Ming Yao, Zhi-Yong Sheng.
J Interferon Cytokine Res, 2012 Jul 18; 32(8). PMID: 22799563    Free PMC article.
Review.
Homeostasis and function of regulatory T cells in HIV/SIV infection.
Maria E Moreno-Fernandez, Pietro Presicce, Claire A Chougnet.
J Virol, 2012 Jul 20; 86(19). PMID: 22811537    Free PMC article.
Review.
Induced and natural regulatory T cells in human cancer.
Theresa L Whiteside, Patrick Schuler, Bastian Schilling.
Expert Opin Biol Ther, 2012 Aug 02; 12(10). PMID: 22849383    Free PMC article.
Review.
The development and function of memory regulatory T cells after acute viral infections.
Ana M Sanchez, Jiangao Zhu, Xiaopei Huang, Yiping Yang.
J Immunol, 2012 Aug 03; 189(6). PMID: 22855712    Free PMC article.
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
Shravan Madireddi, Rich-Henry Schabowsky, +3 authors, Haval Shirwan.
PLoS One, 2012 Aug 08; 7(8). PMID: 22870329    Free PMC article.
Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications.
Luis de la Cruz-Merino, Marylène Lejeune, +6 authors, Tomás Álvaro.
Clin Dev Immunol, 2012 Aug 29; 2012. PMID: 22927872    Free PMC article.
Review.
IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival.
Derek A Wainwright, Irina V Balyasnikova, +6 authors, Maciej S Lesniak.
Clin Cancer Res, 2012 Aug 31; 18(22). PMID: 22932670    Free PMC article.
Highly Cited.
Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases.
Giovanni D'Arena, Giovanni Rossi, +10 authors, Pellegrino Musto.
Mediterr J Hematol Infect Dis, 2012 Sep 14; 4(1). PMID: 22973497    Free PMC article.
Advances in the development of cancer immunotherapies.
Jianjun Gao, Chantale Bernatchez, +2 authors, Patrick Hwu.
Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830    Free PMC article.
Review.
Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma.
Jie Tian, Jie Ma, +8 authors, Shengjun Wang.
PLoS One, 2012 Oct 19; 7(10). PMID: 23077535    Free PMC article.
Mechanism of oral tolerance induction to therapeutic proteins.
Xiaomei Wang, Alexandra Sherman, +4 authors, Roland W Herzog.
Adv Drug Deliv Rev, 2012 Nov 06; 65(6). PMID: 23123293    Free PMC article.
Review.
Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways.
Seon-Yeong Lee, Mi-La Cho, +10 authors, Ho-Youn Kim.
Immunology, 2012 Nov 22; 137(4). PMID: 23167249    Free PMC article.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Review.
Comparative antitumor effect of preventive versus therapeutic vaccines employing B16 melanoma cells genetically modified to express GM-CSF and B7.2 in a murine model.
Antonio Miguel, María José Herrero, +4 authors, Salvador F Aliño.
Toxins (Basel), 2012 Dec 04; 4(11). PMID: 23202306    Free PMC article.
Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interaction.
Sung Hoon Kim, Jeehee Youn.
Immune Netw, 2012 Dec 06; 12(5). PMID: 23213316    Free PMC article.
Protection from reinfection in "Candidatus Mycoplasma turicensis"-infected cats and characterization of the immune response.
Marilisa Novacco, Felicitas S Boretti, +3 authors, Regina Hofmann-Lehmann.
Vet Res, 2012 Dec 12; 43. PMID: 23216686    Free PMC article.
Correlation of circulating glucocorticoid-induced TNFR-related protein ligand levels with disease activity in patients with systemic lupus erythematosus.
Lei Gu, Lingxiao Xu, +3 authors, Miaojia Zhang.
Clin Dev Immunol, 2012 Dec 20; 2012. PMID: 23251213    Free PMC article.
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?
V Kumar.
Purinergic Signal, 2012 Dec 29; 9(2). PMID: 23271562    Free PMC article.
Review.
CD2-mediated regulation of peripheral CD4(+)  CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim.
Yuji Kashiwakura, Daisuke Sakurai, +6 authors, Hidefumi Kojima.
Immunology, 2013 Jan 03; 139(1). PMID: 23278598    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
Inherited variants in regulatory T cell genes and outcome of ovarian cancer.
Ellen L Goode, Melissa DeRycke, +38 authors, Keith L Knutson.
PLoS One, 2013 Feb 06; 8(1). PMID: 23382860    Free PMC article.
Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.
Emilie Dugast, Endre Kiss-Toth, +9 authors, Joanna Ashton-Chess.
J Biol Chem, 2013 Feb 19; 288(14). PMID: 23417677    Free PMC article.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Agonist antibodies to TNFR molecules that costimulate T and NK cells.
Ignacio Melero, Daniel Hirschhorn-Cymerman, +2 authors, Jedd D Wolchok.
Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460535    Free PMC article.
Highly Cited.
Industry pursues co-stimulatory receptor immunomodulators to treat cancer.
Cormac Sheridan.
Nat Biotechnol, 2013 Mar 09; 31(3). PMID: 23471048
Mechanisms of regulatory T cell counter-regulation by innate immunity.
Heidi Yeh, Daniel J Moore, James F Markmann, James I Kim.
Transplant Rev (Orlando), 2013 Mar 12; 27(2). PMID: 23474287    Free PMC article.
Review.
Glucocorticoid-induced TNFR-related protein stimulation reverses cardiac allograft acceptance induced by CD40-CD40L blockade.
Kenneth T Krill, Keri Csencsits-Smith, +3 authors, D Keith Bishop.
Clin Dev Immunol, 2013 May 22; 2013. PMID: 23690829    Free PMC article.
Characterization of dendritic cell and regulatory T cell functions against Mycobacterium tuberculosis infection.
Devin Morris, Brenda Gonzalez, +10 authors, Vishwanath Venketaraman.
Biomed Res Int, 2013 Jun 14; 2013. PMID: 23762843    Free PMC article.
Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma.
Yang Liu, Phong Quang, +12 authors, Irene M Ghobrial.
PLoS One, 2013 Jun 21; 8(6). PMID: 23785514    Free PMC article.
A diametric role for OX40 in the response of effector/memory CD4+ T cells and regulatory T cells to alloantigen.
Gillian Kinnear, Kathryn J Wood, Farnaz Fallah-Arani, Nick D Jones.
J Immunol, 2013 Jul 03; 191(3). PMID: 23817421    Free PMC article.
Thymic versus induced regulatory T cells - who regulates the regulators?
Giovanni Antonio Maria Povoleri, Cristiano Scottà, +3 authors, Behdad Afzali.
Front Immunol, 2013 Jul 03; 4. PMID: 23818888    Free PMC article.
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Wim Pierson, Bénédicte Cauwe, +17 authors, Adrian Liston.
Nat Immunol, 2013 Jul 16; 14(9). PMID: 23852275    Free PMC article.
Highly Cited.
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.
Yannick Bulliard, Rose Jolicoeur, +6 authors, Jennifer L Brogdon.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897982    Free PMC article.
Highly Cited.
Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease.
Theresa L Whiteside, Edwin K Jackson.
Front Immunol, 2013 Jul 31; 4. PMID: 23898333    Free PMC article.
Correlation of increased blood levels of GITR and GITRL with disease severity in patients with primary Sjögren's syndrome.
Xiaoxia Gan, Xiaoke Feng, +4 authors, Miaojia Zhang.
Clin Dev Immunol, 2013 Aug 13; 2013. PMID: 23935647    Free PMC article.
T cell Receptor Signal Transduction in T lymphocytes.
Balachandra K Gorentla, Xiao-Ping Zhong.
J Clin Cell Immunol, 2013 Aug 16; 2012(Suppl 12). PMID: 23946894    Free PMC article.
Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies.
Jeong M Kim, Avi Ashkenazi.
J Exp Med, 2013 Aug 28; 210(9). PMID: 23980122    Free PMC article.
Review.
Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function.
Kui S Voo, Laura Bover, +5 authors, Yong J Liu.
J Immunol, 2013 Sep 10; 191(7). PMID: 24014877    Free PMC article.
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis.
Su-Jin Moon, Jin-Sil Park, +11 authors, Mi-La Cho.
Exp Mol Med, 2013 Oct 05; 45. PMID: 24091748    Free PMC article.
Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine.
Gongxian Liao, Boaz van Driel, +7 authors, Cox Terhorst.
FASEB J, 2013 Oct 11; 28(1). PMID: 24107315    Free PMC article.
TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.
Anna Sledzińska, Saskia Hemmers, +8 authors, Thorsten Buch.
PLoS Biol, 2013 Oct 12; 11(10). PMID: 24115907    Free PMC article.
UXT is a novel regulatory factor of regulatory T cells associated with Foxp3.
Weina Li, Lili Wang, +11 authors, Yingqi Zhang.
Eur J Immunol, 2013 Oct 19; 44(2). PMID: 24136450    Free PMC article.
Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics.
Sachin Gupta, James M Termini, Saravana Kanagavelu, Geoffrey W Stone.
Immunol Res, 2013 Nov 08; 57(1-3). PMID: 24198065    Free PMC article.
Review.
Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.
Mahua Dey, Alan L Chang, +4 authors, Maciej S Lesniak.
J Neuroimmunol, 2013 Nov 26; 266(1-2). PMID: 24268287    Free PMC article.
Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer.
Kouichirou Aida, Reina Miyakawa, +6 authors, Kazunori Aoki.
Cancer Sci, 2013 Dec 03; 105(2). PMID: 24289533    Free PMC article.
Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid.
Jihye Koo, Soochan Kim, +4 authors, Mi-Yeon Kim.
Immune Netw, 2014 Jan 05; 13(6). PMID: 24385942    Free PMC article.
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability.
David A Schaer, Sadna Budhu, +8 authors, Jedd D Wolchok.
Cancer Immunol Res, 2014 Jan 15; 1(5). PMID: 24416730    Free PMC article.
Highly Cited.
Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.
Natasha Whibley, Donna M Maccallum, +7 authors, Andrew M Hall.
Eur J Immunol, 2014 Jan 18; 44(4). PMID: 24435677    Free PMC article.
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs.
Lei Lu, Xiaobing Xu, +3 authors, Xuan Wang.
J Transl Med, 2014 Feb 08; 12. PMID: 24502656    Free PMC article.
Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells.
Gongxian Liao, Michael S O'Keeffe, +5 authors, Cox Terhorst.
Front Immunol, 2014 Feb 20; 5. PMID: 24550919    Free PMC article.
Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells.
Wenting Huang, Kritika Kachapati, +8 authors, William M Ridgway.
J Autoimmun, 2014 Feb 22; 50. PMID: 24556277    Free PMC article.
CD49b, a major marker of regulatory T-cells type 1, predicts the response to antiviral therapy of recurrent hepatitis C after liver transplantation.
Stenard Fabien, Morales Olivier, +7 authors, Conti Filomena.
Biomed Res Int, 2014 Feb 28; 2014. PMID: 24575405    Free PMC article.
HIV-1 adenoviral vector vaccines expressing multi-trimeric BAFF and 4-1BBL enhance T cell mediated anti-viral immunity.
Saravana Kanagavelu, James M Termini, +6 authors, Geoffrey W Stone.
PLoS One, 2014 Mar 04; 9(2). PMID: 24587225    Free PMC article.
Regulatory T-cell vaccination independent of auto-antigen.
David W Pascual, Xinghong Yang, +3 authors, Irina Kochetkova.
Exp Mol Med, 2014 Mar 15; 46. PMID: 24626168    Free PMC article.
Review.
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Shawn A Mahmud, Luke S Manlove, +10 authors, Michael A Farrar.
Nat Immunol, 2014 Mar 19; 15(5). PMID: 24633226    Free PMC article.
Highly Cited.
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
Yukiko Tone, Yoko Kidani, +5 authors, Masahide Tone.
J Immunol, 2014 Mar 19; 192(8). PMID: 24634496    Free PMC article.
Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy.
Fernando Aranda, Erika Vacchelli, +5 authors, Lorenzo Galluzzi.
Oncoimmunology, 2014 Apr 05; 3(1). PMID: 24701370    Free PMC article.
Highly Cited.
CD4⁺CD25⁺/highCD127low/⁻ regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints--analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood.
Babak Moradi, Philipp Schnatzer, +7 authors, Theresa Tretter.
Arthritis Res Ther, 2014 Apr 20; 16(2). PMID: 24742142    Free PMC article.
A naturally occurring CD8(+)CD122(+) T-cell subset as a memory-like Treg family.
Shanshan Li, Qingfeng Xie, +7 authors, Zhenhua Dai.
Cell Mol Immunol, 2014 May 06; 11(4). PMID: 24793406    Free PMC article.
Review.
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy.
David A Schaer, Daniel Hirschhorn-Cymerman, Jedd D Wolchok.
J Immunother Cancer, 2014 May 24; 2. PMID: 24855562    Free PMC article.
Review.
Antigen-Pulsed CpG-ODN-Activated Dendritic Cells Induce Host-Protective Immune Response by Regulating the T Regulatory Cell Functioning in Leishmania donovani-Infected Mice: Critical Role of CXCL10.
Saikat Majumder, Amrita Bhattacharjee, +2 authors, Subrata Majumdar.
Front Immunol, 2014 Jun 14; 5. PMID: 24926293    Free PMC article.
p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression.
Yong Lu, Mingjun Zhang, +9 authors, Qing Yi.
Nat Commun, 2014 Jun 25; 5. PMID: 24957461    Free PMC article.
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β.
O Palomares, M Martín-Fontecha, +4 authors, C A Akdis.
Genes Immun, 2014 Jul 25; 15(8). PMID: 25056447
Highly Cited. Review.
JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.
Anthony Joetham, Michaela Schedel, +6 authors, Erwin W Gelfand.
J Immunol, 2014 Jul 30; 193(5). PMID: 25070841    Free PMC article.
Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor.
Mikiya Ishihara, Naohiro Seo, +5 authors, Hiroshi Shiku.
PLoS One, 2014 Aug 12; 9(8). PMID: 25105508    Free PMC article.
Post-liver transplant hepatitis C virus recurrence: an unresolved thorny problem.
Alberto Grassi, Giorgio Ballardini.
World J Gastroenterol, 2014 Aug 30; 20(32). PMID: 25170198    Free PMC article.
Review.
Lactose inhibits regulatory T-cell-mediated suppression of effector T-cell interferon-γ and IL-17 production.
Monika Paasela, Kaija-Leena Kolho, Outi Vaarala, Jarno Honkanen.
Br J Nutr, 2014 Oct 22; 112(11). PMID: 25331548    Free PMC article.
Levels of interleukin-35 and its relationship with regulatory T-cells in chronic hepatitis B patients.
Yin-yue Shi, Ming-jia Dai, +3 authors, Xue-bing Yan.
Viral Immunol, 2014 Dec 11; 28(2). PMID: 25494369    Free PMC article.
Control of the inflammatory response mechanisms mediated by natural and induced regulatory T-cells in HCV-, HTLV-1-, and EBV-associated cancers.
Laurissa Ouaguia, Dhafer Mrizak, +2 authors, Nadira Delhem.
Mediators Inflamm, 2014 Dec 20; 2014. PMID: 25525301    Free PMC article.
Review.
Classification of current anticancer immunotherapies.
Lorenzo Galluzzi, Erika Vacchelli, +85 authors, Guido Kroemer.
Oncotarget, 2014 Dec 30; 5(24). PMID: 25537519    Free PMC article.
Highly Cited. Review.
Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice.
Kailash Singh, Marcus Hjort, Lina Thorvaldson, Stellan Sandler.
Sci Rep, 2015 Jan 15; 5. PMID: 25586548    Free PMC article.
Methionine enkephalin (MENK) inhibits tumor growth through regulating CD4+Foxp3+ regulatory T cells (Tregs) in mice.
Xuan Li, Yiming Meng, +5 authors, Fengping Shan.
Cancer Biol Ther, 2015 Feb 24; 16(3). PMID: 25701137    Free PMC article.
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.
Maria Fernanda Pascutti, Sulima Geerman, +6 authors, Martijn A Nolte.
PLoS Pathog, 2015 Mar 05; 11(3). PMID: 25738498    Free PMC article.
The role of checkpoints in the treatment of GBM.
Jennifer E Kim, Michael Lim.
J Neurooncol, 2015 Mar 10; 123(3). PMID: 25749875    Free PMC article.
GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity.
Jing Yuan, Xinyi Tang, +8 authors, Shengjun Wang.
Immunol Res, 2015 Mar 17; 62(1). PMID: 25772201
Regulatory T cells turn pathogenic.
Jitao Guo, Xuyu Zhou.
Cell Mol Immunol, 2015 May 06; 12(5). PMID: 25942597    Free PMC article.
Review.
Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.
Simona Ronchetti, Erika Ricci, +4 authors, Carlo Riccardi.
J Immunol Res, 2015 May 12; 2015. PMID: 25961057    Free PMC article.
Review.
IL-1R1 is expressed on both Helios(+) and Helios(-) FoxP3(+) CD4(+) T cells in the rheumatic joint.
M Müller, J Herrath, V Malmström.
Clin Exp Immunol, 2015 Jun 17; 182(1). PMID: 26076982    Free PMC article.
Hyperlipidemia Alters Regulatory T Cell Function and Promotes Resistance to Tolerance Induction Through Costimulatory Molecule Blockade.
J Bagley, J Yuan, A Chandrakar, J Iacomini.
Am J Transplant, 2015 Jun 17; 15(9). PMID: 26079467    Free PMC article.
Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications.
Aitziber Buqué, Norma Bloy, +12 authors, Lorenzo Galluzzi.
Oncoimmunology, 2015 Jul 03; 4(4). PMID: 26137403    Free PMC article.
Review.
GITR agonist enhances vaccination responses in lung cancer.
Li X Zhu, Michael Davoodi, +8 authors, Sherven Sharma.
Oncoimmunology, 2015 Jul 03; 4(4). PMID: 26137407    Free PMC article.
Evolving synergistic combinations of targeted immunotherapies to combat cancer.
Ignacio Melero, David M Berman, +3 authors, John Haanen.
Nat Rev Cancer, 2015 Jul 25; 15(8). PMID: 26205340
Highly Cited. Review.
CD4+VEGFR1(HIGH) T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice.
Jin-Young Shin, Il-Hee Yoon, +8 authors, Chung-Gyu Park.
Cell Mol Immunol, 2015 Jul 28; 12(5). PMID: 26211666    Free PMC article.
Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites.
Powell Perng, Michael Lim.
Front Oncol, 2015 Jul 29; 5. PMID: 26217588    Free PMC article.
Review.
Role of Tumor Necrosis Factor Superfamily in Neuroinflammation and Autoimmunity.
Sandip Sonar, Girdhari Lal.
Front Immunol, 2015 Aug 11; 6. PMID: 26257732    Free PMC article.
Review.
Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells.
Il-Kyu Kim, Byung-Seok Kim, +13 authors, Chang-Yuil Kang.
Nat Med, 2015 Aug 19; 21(9). PMID: 26280119
Immunomodulation of host-protective immune response by regulating Foxp3 expression and Treg function in Leishmania-infected BALB/c mice: critical role of IRF1.
Bidisha Paul Chowdhury, Shibali Das, +5 authors, Subrata Majumdar.
Pathog Dis, 2015 Aug 25; 73(8). PMID: 26297915    Free PMC article.
Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens.
Marina K Baine, Gabriela Turcu, +5 authors, Lucia B Jilaveanu.
Oncotarget, 2015 Sep 01; 6(28). PMID: 26317902    Free PMC article.
In vivo induction of regulatory T cells for immune tolerance in hemophilia.
Xiaomei Wang, Cox Terhorst, Roland W Herzog.
Cell Immunol, 2015 Oct 12; 301. PMID: 26454643    Free PMC article.
Review.
Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response.
Manisha Pathak, Pankaj Sharma, +3 authors, Shailja Misra-Bhattacharya.
Immunology, 2015 Oct 27; 147(2). PMID: 26501838    Free PMC article.
Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients.
Fatina I Fadel, Eman A Elghoroury, +7 authors, Hala M Koura.
Int J Biomed Sci, 2015 Oct 29; 11(3). PMID: 26508906    Free PMC article.
Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells.
Toshiharu Onodera, Atsunori Fukuhara, +6 authors, Iichiro Shimomura.
Sci Rep, 2015 Nov 20; 5. PMID: 26582486    Free PMC article.
Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation.
Dominika J Nowakowska, Stephan Kissler.
J Immunol, 2016 Jan 27; 196(5). PMID: 26810223    Free PMC article.
Inducing and Administering Tregs to Treat Human Disease.
Ana Luisa Perdigoto, Lucienne Chatenoud, Jeffrey A Bluestone, Kevan C Herold.
Front Immunol, 2016 Feb 03; 6. PMID: 26834735    Free PMC article.
Review.
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium.
Eileen S Kim, Jennifer E Kim, +3 authors, Michael Lim.
J Immunol Res, 2016 Feb 18; 2016. PMID: 26881264    Free PMC article.
Review.
Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.
Sarah Sharon Gabriel, Nina Bon, +4 authors, Pietro Ernesto Cippà.
Front Immunol, 2016 Mar 15; 7. PMID: 26973650    Free PMC article.
Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination.
Tammy Oth, Joris Vanderlocht, +2 authors, Wilfred T V Germeraad.
Mediators Inflamm, 2016 Mar 17; 2016. PMID: 26980946    Free PMC article.
Review.
GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii.
Frederico R C Costa, Caroline M Mota, +6 authors, Tiago W P Mineo.
PLoS One, 2016 Mar 31; 11(3). PMID: 27027302    Free PMC article.
GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.
Liping Sun, Hao Jin, Hui Li.
Oncotarget, 2016 Apr 21; 7(27). PMID: 27095576    Free PMC article.
Review.
Induction of regulatory T-cells from memory T-cells is perturbed during acute exacerbation of multiple sclerosis.
Imran H Mohiuddin, Vinodh Pillai, +5 authors, Nitin J Karandikar.
Clin Immunol, 2016 May 08; 166-167. PMID: 27154631    Free PMC article.
Roles of regulatory T cells in cancer immunity.
Yoshiko Takeuchi, Hiroyoshi Nishikawa.
Int Immunol, 2016 May 11; 28(8). PMID: 27160722    Free PMC article.
Highly Cited. Review.
Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.
Adam N Odeh, Jerry W Simecka.
PLoS One, 2016 May 14; 11(5). PMID: 27175511    Free PMC article.
Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity.
Hidetoshi Nakagawa, Jessica M Sido, +3 authors, Hye-Jung Kim.
Proc Natl Acad Sci U S A, 2016 May 18; 113(22). PMID: 27185917    Free PMC article.
The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.
Lindsay K Ward-Kavanagh, Wai Wai Lin, John R Šedý, Carl F Ware.
Immunity, 2016 May 19; 44(5). PMID: 27192566    Free PMC article.
Highly Cited. Review.
Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.
Ruth J Davis, Carter Van Waes, Clint T Allen.
Oral Oncol, 2016 May 25; 58. PMID: 27215705    Free PMC article.
Review.
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
Hristina Nedelkovska, Alexander F Rosenberg, +9 authors, Steven H Bernstein.
PLoS One, 2016 May 27; 11(5). PMID: 27228053    Free PMC article.
Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression.
Emily R Mercadante, Ulrike M Lorenz.
Front Immunol, 2016 Jun 01; 7. PMID: 27242798    Free PMC article.
Review.
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges.
Chrisann Kyi, Michael A Postow.
Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349981    Free PMC article.
Highly Cited. Review.
Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors.
Eric D Brooks, Jonathan E Schoenhals, +4 authors, James W Welsh.
Cancer J, 2016 Jul 22; 22(4). PMID: 27441745    Free PMC article.
Review.
CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas.
Katherine A Murphy, Thomas S Griffith.
Cancers (Basel), 2016 Jul 30; 8(8). PMID: 27472363    Free PMC article.
Review.
Combination strategies to enhance the potency of monocyte-derived dendritic cell-based cancer vaccines.
Ronald J Fecek, Walter J Storkus.
Immunotherapy, 2016 Sep 09; 8(10). PMID: 27605069    Free PMC article.
Review.
Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis.
Yin Zongyi, Chen Dongying, Li Baifeng.
PLoS One, 2016 Sep 10; 11(9). PMID: 27611317    Free PMC article.
Combination treatment with fingolimod and a pathogenic antigen prevents relapse of glucose-6-phosphate isomerase peptide-induced arthritis.
Yuya Yoshida, Norihisa Mikami, +6 authors, Takeyuki Kohno.
Immun Inflamm Dis, 2016 Sep 14; 4(3). PMID: 27621810    Free PMC article.
Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells.
Shan-Shan Meng, Rong Gao, +7 authors, Jing Liu.
Respir Res, 2016 Sep 21; 17(1). PMID: 27646403    Free PMC article.
Novel Immunotherapeutic Approaches for Head and Neck Squamous Cell Carcinoma.
Darrin V Bann, Daniel G Deschler, Neerav Goyal.
Cancers (Basel), 2016 Sep 27; 8(10). PMID: 27669306    Free PMC article.
Review.
Pressure Induced Changes in Adaptive Immune Function in Belugas (Delphinapterus leucas); Implications for Dive Physiology and Health.
Laura A Thompson, Tracy A Romano.
Front Physiol, 2016 Oct 18; 7. PMID: 27746745    Free PMC article.
Regulatory T cells in cancer immunotherapy.
Atsushi Tanaka, Shimon Sakaguchi.
Cell Res, 2016 Dec 21; 27(1). PMID: 27995907    Free PMC article.
Highly Cited. Review.
Role of LAP+CD4+ T cells in the tumor microenvironment of colorectal cancer.
Wu Zhong, Zhi-Yuan Jiang, +9 authors, Feng Gao.
World J Gastroenterol, 2017 Feb 18; 23(3). PMID: 28210081    Free PMC article.
ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.
Klaus Ley, Norbert Gerdes, Holger Winkels.
Arterioscler Thromb Vasc Biol, 2017 Apr 01; 37(5). PMID: 28360089    Free PMC article.
Review.
Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis.
A C Foks, J Kuiper.
Br J Pharmacol, 2017 Apr 04; 174(22). PMID: 28369782    Free PMC article.
Review.
MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential.
Natalie J Tigue, Lisa Bamber, +24 authors, Ross Stewart.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405505    Free PMC article.
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Josiane Lilian Dos Santos Schiavinato, Rodrigo Haddad, +6 authors, Rodrigo Alexandre Panepucci.
Sci Rep, 2017 Jun 18; 7(1). PMID: 28620241    Free PMC article.
GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory.
Nick M Durham, Nick Holoweckyj, +3 authors, Scott H Robbins.
J Immunother Cancer, 2017 Jun 27; 5. PMID: 28649380    Free PMC article.
Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity.
Zuqiang Liu, Xingxing Hao, +5 authors, Zhaoyang You.
Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680744    Free PMC article.
B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection.
Tyler C Moore, Lorena M Gonzaga, +2 authors, Kim J Hasenkrug.
mBio, 2017 Aug 03; 8(4). PMID: 28765225    Free PMC article.
Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy.
Rajeev Shrimali, Shamim Ahmad, +7 authors, Samir N Khleif.
J Immunother Cancer, 2017 Aug 16; 5(1). PMID: 28807056    Free PMC article.
Therapeutic immune monitoring of CD4+CD25+ T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Ziyuan Lu, Na Xu, +8 authors, Xiaoli Liu.
Oncol Lett, 2017 Aug 16; 14(2). PMID: 28808483    Free PMC article.
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients.
Séverine Bézie, Claire Usal, Carole Guillonneau.
J Vis Exp, 2017 Aug 23; (126). PMID: 28829428    Free PMC article.
Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling.
Kai Yang, Daniel Bastardo Blanco, +9 authors, Hongbo Chi.
Nature, 2017 Aug 29; 548(7669). PMID: 28847007    Free PMC article.
Highly Cited.
The promise of immunotherapy in head and neck squamous cell carcinoma: combinatorial immunotherapy approaches.
Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri.
ESMO Open, 2017 Aug 30; 1(6). PMID: 28848660    Free PMC article.
Review.
Regulatory T cells in acute and chronic kidney diseases.
Rahul Sharma, Gilbert R Kinsey.
Am J Physiol Renal Physiol, 2017 Sep 08; 314(5). PMID: 28877881    Free PMC article.
Review.
Immune checkpoint blockade in infectious diseases.
Michelle N Wykes, Sharon R Lewin.
Nat Rev Immunol, 2017 Oct 11; 18(2). PMID: 28990586    Free PMC article.
Highly Cited. Review.
Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein.
Y Maurice Morillon, Scott A Hammond, +2 authors, John W Greiner.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088720    Free PMC article.
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity.
Daniela Schmid, Chun Gwon Park, +9 authors, Michael S Goldberg.
Nat Commun, 2017 Nov 25; 8(1). PMID: 29170511    Free PMC article.
Highly Cited.
Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications.
Mariona Cabo, Rienk Offringa, +3 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209572    Free PMC article.
Review.
TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model.
Michelle L Ratay, Stephen C Balmert, +3 authors, Steven R Little.
Sci Rep, 2017 Dec 14; 7(1). PMID: 29235530    Free PMC article.
Healing potential of Adiantum capillus-veneris L. plant extract on bisphenol A-induced hepatic toxicity in male albino rats.
Qudsia Kanwal, Abdul Qadir, +3 authors, Bushra Munir.
Environ Sci Pollut Res Int, 2018 Feb 16; 25(12). PMID: 29446025
The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.
Yenkel Grinberg-Bleyer, Rachel Caron, +5 authors, Sankar Ghosh.
J Immunol, 2018 Feb 21; 200(7). PMID: 29459403    Free PMC article.
Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions.
Joanna Budna, Mariusz Kaczmarek, +6 authors, Jan Sikora.
J Immunol Res, 2018 May 23; 2018. PMID: 29785404    Free PMC article.
Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells.
Yong Chan Kim, Ai-Hong Zhang, +4 authors, David W Scott.
J Autoimmun, 2018 Jun 03; 92. PMID: 29857928    Free PMC article.
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study.
Ethan M Shevach.
Front Immunol, 2018 Jun 06; 9. PMID: 29868011    Free PMC article.
Highly Cited. Review.
The promise and challenges of immune agonist antibody development in cancer.
Patrick A Mayes, Kenneth W Hance, Axel Hoos.
Nat Rev Drug Discov, 2018 Jun 16; 17(7). PMID: 29904196
Highly Cited. Review.
Thymic tumors and immune checkpoint inhibitors.
Shintaro Yokoyama, Hiroaki Miyoshi.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951302    Free PMC article.
Review.
Next generation immune-checkpoints for cancer therapy.
Chiara Donini, Lorenzo D'Ambrosio, +2 authors, Dario Sangiolo.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951308    Free PMC article.
Review.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.
Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar.
J Autoimmun, 2018 Sep 04; 95. PMID: 30174217    Free PMC article.
Review.
Combination immune checkpoint blockade as an effective therapy for mesothelioma.
Vanessa S Fear, Caitlin Tilsed, +10 authors, Scott A Fisher.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288361    Free PMC article.
Anti-glucocorticoid-induced Tumor Necrosis Factor-Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects.
Jonathan E Schoenhals, Taylor R Cushman, +7 authors, James W Welsh.
Front Immunol, 2018 Oct 09; 9. PMID: 30294332    Free PMC article.
Regulatory T cells in the treatment of disease.
Amir Sharabi, Maria G Tsokos, +3 authors, George C Tsokos.
Nat Rev Drug Discov, 2018 Oct 13; 17(11). PMID: 30310234
Highly Cited. Review.
Foxp3 Molecular Dynamics in Treg in Juvenile Idiopathic Arthritis.
Alastair Copland, David Bending.
Front Immunol, 2018 Oct 20; 9. PMID: 30333832    Free PMC article.
Review.
Regulatory T Cells in Systemic Sclerosis.
Camelia Frantz, Cedric Auffray, Jerome Avouac, Yannick Allanore.
Front Immunol, 2018 Oct 31; 9. PMID: 30374354    Free PMC article.
Review.
Characterization and Comparison of GITR Expression in Solid Tumors.
Luis Vence, Samantha L Bucktrout, +17 authors, Padmanee Sharma.
Clin Cancer Res, 2019 Jul 31; 25(21). PMID: 31358539    Free PMC article.
Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression.
Chloé Laplagne, Marcin Domagala, +7 authors, Mary Poupot.
Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31547627    Free PMC article.
Review.
Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation.
Atika Dhar, Meenakshi Chawla, +8 authors, Soumen Basak.
Sci Rep, 2019 Sep 27; 9(1). PMID: 31554891    Free PMC article.
Current Perspectives in Cancer Immunotherapy.
Theodoulakis Christofi, Stavroula Baritaki, +2 authors, Apostolos Zaravinos.
Cancers (Basel), 2019 Oct 03; 11(10). PMID: 31575023    Free PMC article.
Review.
Activation-induced cell death of self-reactive regulatory T cells drives autoimmunity.
Ester Badami, Olivier N F Cexus, Sonia Quaratino.
Proc Natl Acad Sci U S A, 2019 Dec 11;. PMID: 31818938    Free PMC article.
Local Administration of GITR Agonistic Antibody Induces a Stronger Antitumor Immunity than Systemic Delivery.
Kenta Narumi, Reina Miyakawa, +7 authors, Kazunori Aoki.
Sci Rep, 2019 Apr 05; 9(1). PMID: 30944344    Free PMC article.
Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.
Leonie Brockmann, Shiwa Soukou, +25 authors, Samuel Huber.
Nat Commun, 2018 Dec 24; 9(1). PMID: 30575716    Free PMC article.
Stimulating T Cells Against Cancer With Agonist Immunostimulatory Monoclonal Antibodies.
Xue Han, Matthew D Vesely.
Int Rev Cell Mol Biol, 2019 Jan 13; 342. PMID: 30635089    Free PMC article.
Review.
A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory response in experimental colitis.
V B Freitas Alves, B Coutinho de Sousa, +9 authors, C Ribeiro Cardoso.
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Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface.
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Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy.
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Emerging Novel Therapeutic Approaches for Treatment of Advanced Cutaneous Melanoma.
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So Pathogenic or So What?-A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research.
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Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway.
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