Review
. 2002 Feb; 20:495-549.
doi: 10.1146/annurev.immunol.20.100301.064816.

The immunology of mucosal models of inflammation

Warren Strober 1 Ivan J Fuss  Richard S Blumberg  
Affiliations
  • PMID: 11861611
  •     427 citations

Abstract

In recent years the status of the inflammatory bowel diseases (IBDs) as canonical autoimmune diseases has risen steadily with the recognition that these diseases are, at their crux, abnormalities in mucosal responses to normally harmless antigens in the mucosal microflora and therefore responses to antigens that by their proximity and persistence are equivalent to self-antigens. This new paradigm is in no small measure traceable to the advent of multiple models of mucosal inflammation whose very existence is indicative of the fact that many types of immune imbalance can lead to loss of tolerance for mucosal antigens and thus inflammation centered in the gastrointestinal tract. We analyze the immunology of the IBDs through the lens of the murine models, first by drawing attention to their common features and then by considering individual models at a level of detail necessary to reveal their individual capacities to provide insight into IBD pathogenesis. What emerges is that murine models of mucosal inflammation have given us a road map that allows us to begin to define the immunology of the IBDs in all its complexity and to find unexpected ways to treat these diseases.

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
Dimitris Kontoyiannis, George Boulougouris, +10 authors, George Kollias.
J Exp Med, 2002 Dec 18; 196(12). PMID: 12486099    Free PMC article.
Collagen-binding integrin alpha1beta1 regulates intestinal inflammation in experimental colitis.
Christian F Krieglstein, Wolfgang H Cerwinka, +6 authors, Antonin R de Fougerolles.
J Clin Invest, 2002 Dec 19; 110(12). PMID: 12488427    Free PMC article.
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.
Kevin J Maloy, Laurence Salaun, +3 authors, Fiona Powrie.
J Exp Med, 2003 Jan 08; 197(1). PMID: 12515818    Free PMC article.
Highly Cited.
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
Thomas Welte, Samuel S M Zhang, +12 authors, Xin-Yuan Fu.
Proc Natl Acad Sci U S A, 2003 Feb 07; 100(4). PMID: 12571365    Free PMC article.
Highly Cited.
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice.
Masaya Kobayashi, Mi-Na Kweon, +4 authors, Shizuo Akira.
J Clin Invest, 2003 May 03; 111(9). PMID: 12727921    Free PMC article.
Analysis of gene expression in ceca of Helicobacter hepaticus-infected A/JCr mice before and after development of typhlitis.
Matthew H Myles, Robert S Livingston, +2 authors, Craig L Franklin.
Infect Immun, 2003 Jun 24; 71(7). PMID: 12819073    Free PMC article.
Modulation of cytokine release from colonic explants by bacterial antigens in inflammatory bowel disease.
S Dionne, S Laberge, C Deslandres, E G Seidman.
Clin Exp Immunol, 2003 Jun 26; 133(1). PMID: 12823284    Free PMC article.
BPI-ANCA in transporter associated with antigen presentation (TAP) deficiency: possible role in susceptibility to Gram-negative bacterial infections.
H Schultz, S Schinke, +3 authors, S Gadola.
Clin Exp Immunol, 2003 Jul 19; 133(2). PMID: 12869032    Free PMC article.
Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses.
Holm H Uhlig, Fiona Powrie.
J Clin Invest, 2003 Sep 04; 112(5). PMID: 12952911    Free PMC article.
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells.
Christoph Becker, Stefan Wirtz, +7 authors, Markus F Neurath.
J Clin Invest, 2003 Sep 04; 112(5). PMID: 12952918    Free PMC article.
Role of nod2 in the response of macrophages to toll-like receptor agonists.
Anne-Laure Pauleau, Peter J Murray.
Mol Cell Biol, 2003 Oct 16; 23(21). PMID: 14560001    Free PMC article.
Effects of Rheum tanguticum polysaccharide on TNBS -induced colitis and CD4+T cells in rats.
Li Liu, Zhi-Peng Wang, +5 authors, Si-Yuan Zhou.
World J Gastroenterol, 2003 Oct 17; 9(10). PMID: 14562394    Free PMC article.
Chemokines in eosinophil-associated gastrointestinal disorders.
Simon P Hogan, Marc E Rothenberg, +3 authors, Paul S Foster.
Curr Allergy Asthma Rep, 2003 Dec 19; 4(1). PMID: 14680626
Review.
Chemokines in inflammatory bowel disease.
Konstantinos A Papadakis.
Curr Allergy Asthma Rep, 2003 Dec 19; 4(1). PMID: 14680627
Review.
Detection of species-specific helicobacter ribosomal DNA in intestinal biopsy samples from a population-based cohort of patients with ulcerative colitis.
C J Streutker, C N Bernstein, +2 authors, K Croitoru.
J Clin Microbiol, 2004 Feb 10; 42(2). PMID: 14766833    Free PMC article.
IL-10 and its related cytokines for treatment of inflammatory bowel disease.
Ming-Cai Li, Shao-Heng He.
World J Gastroenterol, 2004 Mar 03; 10(5). PMID: 14991925    Free PMC article.
Review.
Keratins modulate colonocyte electrolyte transport via protein mistargeting.
Diana M Toivola, Selvi Krishnan, +2 authors, M Bishr Omary.
J Cell Biol, 2004 Mar 10; 164(6). PMID: 15007064    Free PMC article.
Colonic epithelial cell mediated suppression of CD4 T cell activation.
S M Cruickshank, L D McVay, +2 authors, S R Carding.
Gut, 2004 Apr 15; 53(5). PMID: 15082586    Free PMC article.
Bacterial flagellin is a dominant antigen in Crohn disease.
Michael J Lodes, Yingzi Cong, +5 authors, Robert M Hershberg.
J Clin Invest, 2004 May 05; 113(9). PMID: 15124021    Free PMC article.
Highly Cited.
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis.
Ivan J Fuss, Frank Heller, +9 authors, Warren Strober.
J Clin Invest, 2004 May 18; 113(10). PMID: 15146247    Free PMC article.
Highly Cited.
Choosing Therapy on the Basis of Disease Classifications in Inflammatory Bowel Disease.
Maria T. Abreu.
Curr Treat Options Gastroenterol, 2004 May 20; 7(3). PMID: 15149579
CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease.
S J Connor, N Paraskevopoulos, +4 authors, M C Grimm.
Gut, 2004 Aug 13; 53(9). PMID: 15306587    Free PMC article.
Enteropathy precedes type 1 diabetes in the BB rat.
S Graham, P Courtois, +3 authors, A Mc I Mowat.
Gut, 2004 Sep 14; 53(10). PMID: 15361491    Free PMC article.
High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study.
William S Mow, Carol J Landers, +5 authors, Stephan R Targan.
Dig Dis Sci, 2004 Sep 25; 49(7-8). PMID: 15387358
Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage.
Daekee Lee, R Scott Pearsall, +3 authors, David W Threadgill.
Mol Cell Biol, 2004 Oct 01; 24(20). PMID: 15456865    Free PMC article.
Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGepsilon26 mice leading to the prevention of colitis.
C Veltkamp, R B Sartor, +6 authors, W Stremmel.
Gut, 2005 Jan 14; 54(2). PMID: 15647183    Free PMC article.
Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets.
Bo Wei, Peter Velazquez, +5 authors, Jonathan Braun.
Proc Natl Acad Sci U S A, 2005 Feb 03; 102(6). PMID: 15684084    Free PMC article.
Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis.
R Newman, N Cuan, +3 authors, M C Grimm.
Clin Exp Immunol, 2005 Feb 26; 139(3). PMID: 15730386    Free PMC article.
Emergent autoimmunity in graft-versus-host disease.
Elizabeth Tivol, Richard Komorowski, William R Drobyski.
Blood, 2005 Mar 05; 105(12). PMID: 15746077    Free PMC article.
The RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss.
A R Moschen, A Kaser, +5 authors, H Tilg.
Gut, 2005 Mar 09; 54(4). PMID: 15753532    Free PMC article.
Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.
Kyoko Katakura, Jongdae Lee, +3 authors, Eyal Raz.
J Clin Invest, 2005 Mar 15; 115(3). PMID: 15765149    Free PMC article.
Highly Cited.
Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea-pig.
Alan E Lomax, Gary M Mawe, Keith A Sharkey.
J Physiol, 2005 Mar 19; 564(Pt 3). PMID: 15774518    Free PMC article.
CD4+ T-cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae-induced colitis in pigs.
Raquel Hontecillas, Josep Bassaganya-Riera, +2 authors, Michael J Wannemuehler.
Immunology, 2005 Apr 12; 115(1). PMID: 15819705    Free PMC article.
Impaired B cell responses to orally administered antigens in lamina propria but not Peyer's patches of Galphai2-deficient mice prior to colitis.
Lena Ohman, Rolf-Göran Aström, Elisabeth Hultgren Hörnquist.
Immunology, 2005 May 12; 115(2). PMID: 15885134    Free PMC article.
Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.
Makoto Arita, Masaru Yoshida, +5 authors, Charles N Serhan.
Proc Natl Acad Sci U S A, 2005 May 14; 102(21). PMID: 15890784    Free PMC article.
Highly Cited.
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells.
Joo Sung Kim, Christian Jobin.
Immunology, 2005 Jun 11; 115(3). PMID: 15946255    Free PMC article.
In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.
C Becker, M C Fantini, +5 authors, M F Neurath.
Gut, 2005 Jun 14; 54(7). PMID: 15951540    Free PMC article.
Diminished cytokine signalling against bacterial components in mononuclear leucocytes from ulcerative colitis patients after leukocytapheresis.
K Mitsuyama, A Suzuki, +9 authors, M Sata.
Clin Exp Immunol, 2005 Jun 17; 141(1). PMID: 15958079    Free PMC article.
Animal models of intestinal inflammation: ineffective communication between coalition members.
Robin G Lorenz, Vance J McCracken, Charles O Elson.
Springer Semin Immunopathol, 2005 Jul 20; 27(2). PMID: 16028027
Review.
Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides.
Stefan Fichtner-Feigl, Ivan J Fuss, +2 authors, Atsushi Kitani.
J Clin Invest, 2005 Oct 22; 115(11). PMID: 16239967    Free PMC article.
Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.
Laura T Donlin, Nichole M Danzl, Celestine Wanjalla, Konstantina Alexandropoulos.
Mol Cell Biol, 2005 Nov 30; 25(24). PMID: 16314525    Free PMC article.
Reduced Paneth cell alpha-defensins in ileal Crohn's disease.
Jan Wehkamp, Nita H Salzman, +14 authors, Charles L Bevins.
Proc Natl Acad Sci U S A, 2005 Dec 07; 102(50). PMID: 16330776    Free PMC article.
Highly Cited.
Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease.
E Gonzalez-Rey, A Fernandez-Martin, A Chorny, M Delgado.
Gut, 2006 Jan 13; 55(6). PMID: 16401687    Free PMC article.
Layers of mutualism with commensal bacteria protect us from intestinal inflammation.
C Mueller, A J Macpherson.
Gut, 2006 Jan 13; 55(2). PMID: 16407387    Free PMC article.
Review.
Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis.
Tae Woon Kim, Jae Nam Seo, +4 authors, Kwon Ik Oh.
World J Gastroenterol, 2006 Feb 17; 12(2). PMID: 16482634    Free PMC article.
The primary defect in experimental ileitis originates from a nonhematopoietic source.
Timothy S Olson, Brian K Reuter, +10 authors, Theresa T Pizarro.
J Exp Med, 2006 Mar 01; 203(3). PMID: 16505137    Free PMC article.
Recommendations for improved use of the murine TNBS-induced colitis model in evaluating anti-inflammatory properties of lactic acid bacteria: technical and microbiological aspects.
Benoit Foligné, Sophie Nutten, +4 authors, Bruno Pot.
Dig Dis Sci, 2006 Mar 15; 51(2). PMID: 16534687
Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease.
Elena Gonzalez-Rey, Nieves Varela, +3 authors, Mario Delgado.
Proc Natl Acad Sci U S A, 2006 Mar 16; 103(11). PMID: 16537513    Free PMC article.
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease.
M Adachi, R Kurotani, +8 authors, F J Gonzalez.
Gut, 2006 Mar 21; 55(8). PMID: 16547072    Free PMC article.
The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis.
Kiran Assi, Rex Pillai, +2 authors, Baljinder Salh.
Immunology, 2006 Apr 25; 118(1). PMID: 16630028    Free PMC article.
The IL-23/IL-17 axis in inflammation.
Yoichiro Iwakura, Harumichi Ishigame.
J Clin Invest, 2006 May 04; 116(5). PMID: 16670765    Free PMC article.
Highly Cited.
Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis.
Yuan Wang, Lihua Wang, +6 authors, Deborah C Rubin.
J Clin Invest, 2006 May 20; 116(6). PMID: 16710473    Free PMC article.
Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.
Frank Leithäuser, Tamara Meinhardt-Krajina, +3 authors, Jörg Reimann.
Am J Pathol, 2006 May 26; 168(6). PMID: 16723705    Free PMC article.
GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice.
L Santucci, M Agostini, +6 authors, C Riccardi.
Gut, 2006 Jun 10; 56(1). PMID: 16763055    Free PMC article.
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.
Simon P Hogan, Luqman Seidu, +9 authors, Marc E Rothenberg.
J Allergy Clin Immunol, 2006 Jul 04; 118(1). PMID: 16815164    Free PMC article.
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
Masaru Yoshida, Kanna Kobayashi, +12 authors, Richard S Blumberg.
J Clin Invest, 2006 Jul 15; 116(8). PMID: 16841095    Free PMC article.
Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice.
Kathryn A Eaton, Lucy H Benson, Jennifer Haeger, Brian M Gray.
Infect Immun, 2006 Jul 25; 74(8). PMID: 16861655    Free PMC article.
Role of interleukin 6 in a murine model of Crohn's ileitis: are cytokine/anticytokine strategies the future for IBD therapies?
T T Pizarro, S A De La Rue, F Cominelli.
Gut, 2006 Aug 15; 55(9). PMID: 16905692    Free PMC article.
Etiopathogenesis of inflammatory bowel diseases.
Silvio Danese, Claudio Fiocchi.
World J Gastroenterol, 2006 Aug 29; 12(30). PMID: 16937461    Free PMC article.
Review.
Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule.
Henri Braat, Peter McGuirk, +5 authors, Kingston H G Mills.
Gut, 2006 Sep 06; 56(3). PMID: 16952913    Free PMC article.
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.
Laila D McVay, Sue A Keilbaugh, +12 authors, Gary D Wu.
J Clin Invest, 2006 Oct 07; 116(11). PMID: 17024245    Free PMC article.
Interleukin-23 drives innate and T cell-mediated intestinal inflammation.
Sophie Hue, Philip Ahern, +5 authors, Kevin J Maloy.
J Exp Med, 2006 Oct 13; 203(11). PMID: 17030949    Free PMC article.
Highly Cited.
Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats.
Nadia Osman, Diya Adawi, +3 authors, Bengt Jeppsson.
BMC Gastroenterol, 2006 Oct 31; 6. PMID: 17069659    Free PMC article.
Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses.
Evelyn A Kurt-Jones, LuCheng Cao, +12 authors, Timothy C Wang.
Infect Immun, 2006 Nov 15; 75(1). PMID: 17101660    Free PMC article.
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
Carole Berruyer, Laurent Pouyet, +7 authors, Franck Galland.
J Exp Med, 2006 Dec 06; 203(13). PMID: 17145956    Free PMC article.
Lactobacillus paracasei subsp. paracasei B21060 suppresses human T-cell proliferation.
Ilaria Peluso, Daniele Fina, +9 authors, Giovanni Monteleone.
Infect Immun, 2007 Jan 24; 75(4). PMID: 17242060    Free PMC article.
Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli.
M M Heimesaat, A Fischer, +7 authors, S Bereswill.
Gut, 2007 Jan 27; 56(7). PMID: 17255219    Free PMC article.
The fundamental basis of inflammatory bowel disease.
Warren Strober, Ivan Fuss, Peter Mannon.
J Clin Invest, 2007 Mar 03; 117(3). PMID: 17332878    Free PMC article.
Highly Cited. Review.
Demonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresis.
Yoko Yokoyama, Ken Fukunaga, +9 authors, Takayuki Matsumoto.
Dig Dis Sci, 2007 Apr 04; 52(10). PMID: 17404876
Is the sugar always sweet in intestinal inflammation?
Emiko Mizoguchi, Atsushi Mizoguchi.
Immunol Res, 2007 May 15; 37(1). PMID: 17496346
Review.
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
Guangyu An, Bo Wei, +5 authors, Lijun Xia.
J Exp Med, 2007 May 23; 204(6). PMID: 17517967    Free PMC article.
Highly Cited.
Homologous high-throughput expression and purification of highly conserved E coli proteins.
Asgar Ergin, Konrad Büssow, +3 authors, Thomas Adam.
Microb Cell Fact, 2007 Jun 08; 6. PMID: 17553160    Free PMC article.
Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis.
Jen Chang, Julia J Hoy, +3 authors, Aditi Bhargava.
Peptides, 2007 Jun 26; 28(7). PMID: 17586086    Free PMC article.
Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.
A E Lomax, M O'Reilly, S Neshat, S J Vanner.
J Physiol, 2007 Jul 07; 583(Pt 2). PMID: 17615098    Free PMC article.
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4.
Markus M Heimesaat, André Fischer, +13 authors, Stefan Bereswill.
PLoS One, 2007 Jul 27; 2(7). PMID: 17653282    Free PMC article.
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.
Agnes Coste, Laurent Dubuquoy, +10 authors, Kristina Schoonjans.
Proc Natl Acad Sci U S A, 2007 Aug 03; 104(32). PMID: 17670946    Free PMC article.
Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease.
S Kugathasan, L J Saubermann, +6 authors, C Fiocchi.
Gut, 2007 Aug 08; 56(12). PMID: 17682002    Free PMC article.
Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets.
Dina Montufar-Solis, Heuy-Ching Wang, John R Klein.
J Leukoc Biol, 2007 Aug 19; 82(5). PMID: 17702824    Free PMC article.
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein.
Deanna D Nguyen, Michel H Maillard, +7 authors, Scott B Snapper.
Gastroenterology, 2007 Sep 04; 133(4). PMID: 17764675    Free PMC article.
Rheostat regulation of integrin-mediated leukocyte adhesion.
Ivor S Douglas, Themistocles Dassopoulos.
J Clin Invest, 2007 Sep 06; 117(9). PMID: 17786236    Free PMC article.
Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.
Eun Jeong Park, J Rodrigo Mora, +5 authors, Motomu Shimaoka.
J Clin Invest, 2007 Sep 06; 117(9). PMID: 17786243    Free PMC article.
NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction.
Zhiqiong Yang, Ivan J Fuss, +5 authors, Atsushi Kitani.
Gastroenterology, 2007 Oct 05; 133(5). PMID: 17915219    Free PMC article.
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.
Kazumichi Abe, Kim Phung Nguyen, +8 authors, Eyal Raz.
Proc Natl Acad Sci U S A, 2007 Oct 19; 104(43). PMID: 17942668    Free PMC article.
Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease.
Mayumi Kawada, Atsuko Arihiro, Emiko Mizoguchi.
World J Gastroenterol, 2007 Oct 24; 13(42). PMID: 17948932    Free PMC article.
Review.
High-fat diet modulates non-CD1d-restricted natural killer T cells and regulatory T cells in mouse colon and exacerbates experimental colitis.
X Ma, M Torbenson, +2 authors, Z Li.
Clin Exp Immunol, 2007 Nov 10; 151(1). PMID: 17991290    Free PMC article.
Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis.
H-S Kwon, S-M Oh, J-K Kim.
Clin Exp Immunol, 2007 Nov 17; 151(1). PMID: 18005263    Free PMC article.
Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice.
Y W Chung, J H Choi, +2 authors, D S Han.
Clin Exp Immunol, 2007 Nov 17; 151(1). PMID: 18005362    Free PMC article.
Enhanced transduction of colonic cell lines in vitro and the inflamed colon in mice by viral vectors, derived from adeno-associated virus serotype 2, using virus-microbead conjugates bearing lectin.
Samuel J Farlow, Alan Jerusalmi, Takeshi Sano.
BMC Biotechnol, 2007 Nov 30; 7. PMID: 18045466    Free PMC article.
Massive but selective cytokine dysregulation in the colon of IL-10-/- mice revealed by multiplex analysis.
Dina Montufar-Solis, Jeremy Schaefer, M John Hicks, John R Klein.
Int Immunol, 2007 Nov 30; 20(1). PMID: 18046045    Free PMC article.
Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis.
Maho Ikeda, Fuminao Takeshima, +4 authors, Shigeru Kohno.
Dig Dis Sci, 2007 Dec 01; 53(7). PMID: 18049901
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Guillaume Dalmasso, Laetitia Charrier-Hisamuddin, +3 authors, Didier Merlin.
Gastroenterology, 2007 Dec 07; 134(1). PMID: 18061177    Free PMC article.
Innate immunity in inflammatory bowel disease: a disease hypothesis.
D J B Marks, A W Segal.
J Pathol, 2007 Dec 29; 214(2). PMID: 18161747    Free PMC article.
Review.
Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival.
Renat Shaykhiev, Jürgen Behr, Robert Bals.
PLoS One, 2008 Jan 03; 3(1). PMID: 18167552    Free PMC article.
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.
Tomohiro Watanabe, Naoki Asano, +5 authors, Warren Strober.
J Clin Invest, 2008 Jan 12; 118(2). PMID: 18188453    Free PMC article.
Highly Cited.
A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis.
Johnson Ho, Courtney C Kurtz, +3 authors, Jesús Rivera-Nieves.
J Immunol, 2008 Feb 06; 180(4). PMID: 18250468    Free PMC article.
Integration of B cells and CD8+ T in the protective regulation of systemic epithelial inflammation.
Bo Wei, Michael McPherson, +4 authors, Jonathan Braun.
Clin Immunol, 2008 Feb 20; 127(3). PMID: 18282744    Free PMC article.
Inflammatory bowel disease, past, present and future: lessons from animal models.
Atsushi Mizoguchi, Emiko Mizoguchi.
J Gastroenterol, 2008 Feb 26; 43(1). PMID: 18297430
Review.
An antibiotic-responsive mouse model of fulminant ulcerative colitis.
Silvia S Kang, Seth M Bloom, +4 authors, Paul M Allen.
PLoS Med, 2008 Mar 06; 5(3). PMID: 18318596    Free PMC article.
Feeding our immune system: impact on metabolism.
Isabelle Wolowczuk, Claudie Verwaerde, +4 authors, Corinne Grangette.
Clin Dev Immunol, 2008 Mar 20; 2008. PMID: 18350123    Free PMC article.
Review.
IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.
Masaki Tajima, Daiko Wakita, +7 authors, Takashi Nishimura.
J Exp Med, 2008 Apr 23; 205(5). PMID: 18426983    Free PMC article.
Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice.
Qian Jia, Joanne R Lupton, +10 authors, Robert S Chapkin.
Cancer Res, 2008 May 17; 68(10). PMID: 18483285    Free PMC article.
Leukocyte adhesion molecules in animal models of inflammatory bowel disease.
Jesús Rivera-Nieves, Gezahegn Gorfu, Klaus Ley.
Inflamm Bowel Dis, 2008 Jun 05; 14(12). PMID: 18523998    Free PMC article.
Review.
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.
Jonas Mudter, Lioubov Amoussina, +15 authors, Markus F Neurath.
J Clin Invest, 2008 Jun 07; 118(7). PMID: 18535667    Free PMC article.
Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice.
M S Islam, T Murata, +5 authors, H Ozaki.
Br J Pharmacol, 2008 Jun 10; 154(4). PMID: 18536734    Free PMC article.
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.
Hidetoshi Takedatsu, Kathrin S Michelsen, +5 authors, Stephan R Targan.
Gastroenterology, 2008 Jul 05; 135(2). PMID: 18598698    Free PMC article.
Highly Cited.
Inflammatory bowel disease in rats: bacterial and chemical interaction.
Inaya-Abdallah Hajj Hussein, Rania Tohme, +5 authors, Abdo Jurjus.
World J Gastroenterol, 2008 Jul 09; 14(25). PMID: 18609687    Free PMC article.
The effect of Saccharomyces boulardii on human colon cells and inflammation in rats with trinitrobenzene sulfonic acid-induced colitis.
Sang Kil Lee, Youn Wha Kim, +2 authors, Hyo Jong Kim.
Dig Dis Sci, 2008 Jul 10; 54(2). PMID: 18612822
Pathophysiological Roles of PPARgamma in Gastrointestinal Epithelial Cells.
Brian M Necela, E Aubrey Thompson.
PPAR Res, 2008 Jul 11; 2008. PMID: 18615192    Free PMC article.
Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.
Sarah Brewer, Michael McPherson, +7 authors, Jonathan Braun.
Gastroenterology, 2008 Jul 22; 135(3). PMID: 18639553    Free PMC article.
Inflammatory bowel disease: Moving toward a stem cell-based therapy.
Giacomo Lanzoni, Giulia Roda, +2 authors, Gian Paolo Bagnara.
World J Gastroenterol, 2008 Aug 14; 14(29). PMID: 18698675    Free PMC article.
Review.
TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig.
P A Lynn, B N Chen, +2 authors, S J H Brookes.
Am J Physiol Gastrointest Liver Physiol, 2008 Aug 30; 295(4). PMID: 18755810    Free PMC article.
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.
Colby Zaph, Yurong Du, +9 authors, David Artis.
J Exp Med, 2008 Sep 03; 205(10). PMID: 18762568    Free PMC article.
Highly Cited.
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
Arthur Kaser, Ann-Hwee Lee, +8 authors, Richard S Blumberg.
Cell, 2008 Sep 09; 134(5). PMID: 18775308    Free PMC article.
Highly Cited.
Role of STAT3 in inflammatory bowel disease.
Ken Sugimoto.
World J Gastroenterol, 2008 Sep 09; 14(33). PMID: 18777586    Free PMC article.
Review.
Roles of galectins in inflammatory bowel disease.
Akira Hokama, Emiko Mizoguchi, Atsushi Mizoguchi.
World J Gastroenterol, 2008 Sep 09; 14(33). PMID: 18777589    Free PMC article.
Review.
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease.
Megan E Himmel, Gijs Hardenberg, +2 authors, Megan K Levings.
Immunology, 2008 Sep 19; 125(2). PMID: 18798918    Free PMC article.
Review.
American ginseng suppresses inflammation and DNA damage associated with mouse colitis.
Yu Jin, Venkata S Kotakadi, +12 authors, Lorne J Hofseth.
Carcinogenesis, 2008 Sep 20; 29(12). PMID: 18802031    Free PMC article.
CD44 deficiency attenuates chronic murine ileitis.
Colm B Collins, Johnson Ho, +6 authors, Jesús Rivera-Nieves.
Gastroenterology, 2008 Oct 16; 135(6). PMID: 18854186    Free PMC article.
Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer.
Robert S Chapkin, Barton A Kamen, +5 authors, Richard H Finnell.
J Nutr Biochem, 2008 Oct 18; 20(8). PMID: 18926688    Free PMC article.
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis.
Philip Alex, Nicholas C Zachos, +5 authors, Xuhang Li.
Inflamm Bowel Dis, 2008 Oct 24; 15(3). PMID: 18942757    Free PMC article.
Highly Cited.
T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.
Yu Yang, Jiangnan Xu, +2 authors, Yaozhong Ding.
J Immunol, 2008 Dec 04; 181(12). PMID: 19050290    Free PMC article.
Regulatory T cells modulate staphylococcal enterotoxin B-induced effector T-cell activation and acceleration of colitis.
Armando Heriazon, Pengfei Zhou, +4 authors, Kenneth Croitoru.
Infect Immun, 2008 Dec 10; 77(2). PMID: 19064639    Free PMC article.
CEACAM1 and the regulation of mucosal inflammation.
T Nagaishi, Z Chen, +3 authors, R S Blumberg.
Mucosal Immunol, 2008 Dec 23; 1 Suppl 1. PMID: 19079227    Free PMC article.
Review.
Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis.
Ariel Munitz, Amanda Waddell, +4 authors, Marc E Rothenberg.
J Allergy Clin Immunol, 2008 Dec 17; 122(6). PMID: 19084112    Free PMC article.
Efficient colonic mucosal wound repair requires Trem2 signaling.
Hiroshi Seno, Hiroyuki Miyoshi, +3 authors, Thaddeus S Stappenbeck.
Proc Natl Acad Sci U S A, 2008 Dec 26; 106(1). PMID: 19109436    Free PMC article.
Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation.
Gabriele Hoermannsperger, Gabriele Hörmannsperger, +8 authors, Dirk Haller.
PLoS One, 2009 Feb 07; 4(2). PMID: 19197385    Free PMC article.
Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease.
Arthur Kaser, Richard S Blumberg.
Semin Immunol, 2009 Feb 25; 21(3). PMID: 19237300    Free PMC article.
Review.
Effects of trefoil peptide 3 on expression of TNF-alpha, TLR4, and NF-kappaB in trinitrobenzene sulphonic acid induced colitis mice.
Xu Teng, Ling-Fen Xu, +2 authors, Mei Sun.
Inflammation, 2009 Feb 25; 32(2). PMID: 19238529
Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats.
Celso L R Belmiro, Morgana T L Castelo-Branco, +5 authors, Heitor S P de Souza.
J Biol Chem, 2009 Mar 05; 284(17). PMID: 19258310    Free PMC article.
Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women.
Zhenwu Lin, Lisa Poritz, +9 authors, Walter A Koltun.
Dig Dis Sci, 2009 Mar 19; 55(3). PMID: 19294505
The serum D-xylose test as a useful tool to identify malabsorption in rats with antigen specific gut inflammatory reaction.
Danielle Mota Fontes Antunes, Janilda Pacheco da Costa, +5 authors, Gilberto Perez Cardoso.
Int J Exp Pathol, 2009 Apr 02; 90(2). PMID: 19335552    Free PMC article.
Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip.
Chien-Sheng Chen, Sean Sullivan, +14 authors, Xuhang Li.
Mol Cell Proteomics, 2009 Apr 10; 8(8). PMID: 19357087    Free PMC article.
Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis.
Yueming Tang, Fabian Preuss, +2 authors, Ali Keshavarzian.
Sleep Med, 2009 May 01; 10(6). PMID: 19403332    Free PMC article.
Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria.
Carol A Albright, R Balfour Sartor, Susan L Tonkonogy.
Immunol Lett, 2009 May 12; 123(1). PMID: 19428554    Free PMC article.
Crohn's disease: an immune deficiency state.
Daniel J B Marks, Farooq Z Rahman, Gavin W Sewell, Anthony W Segal.
Clin Rev Allergy Immunol, 2009 May 14; 38(1). PMID: 19437144    Free PMC article.
Review.
Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.
Shaival H Davé, Jeremy S Tilstra, +7 authors, Scott E Plevy.
J Leukoc Biol, 2009 May 21; 86(3). PMID: 19454652    Free PMC article.
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.
Luke A J O'Neill, Clare E Bryant, Sarah L Doyle.
Pharmacol Rev, 2009 May 29; 61(2). PMID: 19474110    Free PMC article.
Highly Cited. Review.
A probiotic strain of Escherichia coli, Nissle 1917, given orally exerts local and systemic anti-inflammatory effects in lipopolysaccharide-induced sepsis in mice.
B Arribas, M E Rodríguez-Cabezas, +7 authors, J Gálvez.
Br J Pharmacol, 2009 Jun 03; 157(6). PMID: 19486007    Free PMC article.
Interleukin-23 and Th17 cells in the control of gut inflammation.
Ivan Monteleone, Francesco Pallone, Giovanni Monteleone.
Mediators Inflamm, 2009 Jun 09; 2009. PMID: 19503799    Free PMC article.
Review.
Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in the transfer model of colitis.
Melissa E Gove, Maria Pini, +2 authors, Giamila Fantuzzi.
Cytokine, 2009 Jun 13; 47(2). PMID: 19520591    Free PMC article.
FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
Wen Zhou, Qian Cao, +4 authors, Zhi-Ping Liu.
Gastroenterology, 2009 Jun 30; 137(4). PMID: 19560465    Free PMC article.
Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats.
Tarek Boussetta, Houssam Raad, +4 authors, Jamel El-Benna.
PLoS One, 2009 Aug 04; 4(7). PMID: 19649246    Free PMC article.
Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease.
D C Baumgart, S Thomas, +9 authors, A Radbruch.
Clin Exp Immunol, 2009 Aug 12; 157(3). PMID: 19664152    Free PMC article.
An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.
Kanna Kobayashi, Shuo-Wang Qiao, +3 authors, Richard S Blumberg.
Gastroenterology, 2009 Aug 12; 137(5). PMID: 19664634    Free PMC article.
Infliximab in ulcerative colitis.
Avi Levin, Oren Shibolet.
Biologics, 2009 Aug 27; 2(3). PMID: 19707369    Free PMC article.
Functional protease-activated receptors in the dorsal motor nucleus of the vagus.
H Wang, X Wu, +4 authors, W Zhang.
Neurogastroenterol Motil, 2009 Sep 02; 22(4). PMID: 19719510    Free PMC article.
Proinflammatory Th2 cytokines induce production of thymic stromal lymphopoietin in human colonic epithelial cells.
Junya Tanaka, Kazuyuki Saga, +4 authors, Norihiko Watanabe.
Dig Dis Sci, 2009 Sep 17; 55(7). PMID: 19757042    Free PMC article.
Intestinal effector T cells in health and disease.
Craig L Maynard, Casey T Weaver.
Immunity, 2009 Sep 22; 31(3). PMID: 19766082    Free PMC article.
Review.
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.
Ashutosh Chaudhry, Dipayan Rudra, +4 authors, Alexander Y Rudensky.
Science, 2009 Oct 03; 326(5955). PMID: 19797626    Free PMC article.
Highly Cited.
Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse.
Eoin N McNamee, Joshua D Wermers, +9 authors, Jesçs Rivera-Nieves.
Inflamm Bowel Dis, 2009 Oct 27; 16(5). PMID: 19856411    Free PMC article.
Role of beta7 integrins in intestinal lymphocyte homing and retention.
G Gorfu, J Rivera-Nieves, K Ley.
Curr Mol Med, 2009 Oct 29; 9(7). PMID: 19860663    Free PMC article.
Highly Cited. Review.
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice.
Edwin F de Zoeten, Liqing Wang, +2 authors, Wayne W Hancock.
Gastroenterology, 2009 Nov 03; 138(2). PMID: 19879272    Free PMC article.
Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's disease.
Gisella L Puga Yung, Meredith Fidler, +9 authors, Salvatore Albani.
PLoS One, 2009 Nov 06; 4(11). PMID: 19888320    Free PMC article.
ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice.
Jeremy S Schaefer, Dina Montufar-Solis, Nadarajah Vigneswaran, John R Klein.
J Leukoc Biol, 2009 Nov 06; 87(2). PMID: 19889730    Free PMC article.
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.
E C Lavelle, C Murphy, L A J O'Neill, E M Creagh.
Mucosal Immunol, 2009 Nov 06; 3(1). PMID: 19890268    Free PMC article.
Review.
Effect of azithromycin on acute inflammatory lesions and colonic bacterial load in a murine model of experimental colitis.
Sanja Plesko, Marko Banić, +4 authors, Ivo Rotkvić.
Dig Dis Sci, 2009 Nov 20; 55(8). PMID: 19924536
Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis.
D A Hill, C Hoffmann, +5 authors, D Artis.
Mucosal Immunol, 2009 Nov 27; 3(2). PMID: 19940845    Free PMC article.
Highly Cited.
Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.
Melba Muñoz, Markus M Heimesaat, +19 authors, Oliver Liesenfeld.
J Exp Med, 2009 Dec 10; 206(13). PMID: 19995958    Free PMC article.
Highly Cited.
Loss of CD103+ intestinal dendritic cells during colonic inflammation.
Ulrike G Strauch, Nicole Grunwald, +2 authors, Heiko C Rath.
World J Gastroenterol, 2009 Dec 30; 16(1). PMID: 20039445    Free PMC article.
MicroRNA155 is induced in activated CD4(+) T cells of TNBS-induced colitis in mice.
Da-Fan Chen, Bang-Dong Gong, +3 authors, Yao-Zong Yuan.
World J Gastroenterol, 2010 Feb 10; 16(7). PMID: 20143464    Free PMC article.
Noninvasive methods in evaluation of inflammatory bowel disease: where do we stand now? An update.
Cansel Turkay, Benan Kasapoglu.
Clinics (Sao Paulo), 2010 Feb 27; 65(2). PMID: 20186307    Free PMC article.
Review.
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.
Michael J Barnes, Halil Aksoylar, +16 authors, Kasper Hoebe.
J Immunol, 2010 Mar 02; 184(7). PMID: 20190135    Free PMC article.
Inflammatory bowel disease.
Arthur Kaser, Sebastian Zeissig, Richard S Blumberg.
Annu Rev Immunol, 2010 Mar 03; 28. PMID: 20192811    Free PMC article.
Highly Cited. Review.
T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.
Jia-Fei Cheng, Yue-Ji Ning, +2 authors, Lin Lin.
World J Gastroenterol, 2010 Mar 12; 16(10). PMID: 20222171    Free PMC article.
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
Md Hasan Zaki, Kelli L Boyd, +3 authors, Thirumala-Devi Kanneganti.
Immunity, 2010 Mar 23; 32(3). PMID: 20303296    Free PMC article.
Highly Cited.
Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease.
Katherine Wendelsdorf, Josep Bassaganya-Riera, Raquel Hontecillas, Stephen Eubank.
J Theor Biol, 2010 Apr 07; 264(4). PMID: 20362587    Free PMC article.
Targeting improves MSC treatment of inflammatory bowel disease.
In Kap Ko, Byung-Gyu Kim, +4 authors, James E Dennis.
Mol Ther, 2010 Apr 15; 18(7). PMID: 20389289    Free PMC article.
Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.
Ariel Munitz, Eric T Cole, +8 authors, Simon P Hogan.
Gastroenterology, 2010 Apr 20; 139(2). PMID: 20398663    Free PMC article.
Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease.
Saroj K Mohapatra, Amir J Guri, +5 authors, Josep Bassaganya-Riera.
PLoS One, 2010 Apr 28; 5(4). PMID: 20422041    Free PMC article.
Dietary phenethylisothiocyanate attenuates bowel inflammation in mice.
Moul Dey, Peter Kuhn, +3 authors, Ilya Raskin.
BMC Chem Biol, 2010 Apr 29; 10. PMID: 20423518    Free PMC article.
TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis.
Mario Noti, Nadia Corazza, +2 authors, Thomas Brunner.
J Exp Med, 2010 May 05; 207(5). PMID: 20439544    Free PMC article.
Connection between inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta signaling.
Suntaek Hong, Ho-Jae Lee, Seong Jin Kim, Ki-Baik Hahm.
World J Gastroenterol, 2010 May 05; 16(17). PMID: 20440848    Free PMC article.
Review.
Expression of interleukin 6 in brain and colon of rats with TNBS-induced colitis.
Kai Wang, Chuan-Ping Yuan, +7 authors, Ju-Xiong Liu.
World J Gastroenterol, 2010 May 12; 16(18). PMID: 20458762    Free PMC article.
The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival.
Meher K Rahman, Emilie H Midtling, +6 authors, William A Faubion.
J Immunol, 2010 May 21; 184(12). PMID: 20483763    Free PMC article.
Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis.
Arthur Kaser, Eduardo Martínez-Naves, Richard S Blumberg.
Curr Opin Gastroenterol, 2010 May 25; 26(4). PMID: 20495455    Free PMC article.
Review.
The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease.
Amir J Guri, Saroj K Mohapatra, +2 authors, Josep Bassaganya-Riera.
BMC Gastroenterol, 2010 Jun 12; 10. PMID: 20537136    Free PMC article.
Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease.
J Anthony Brandon, Jacqueline Perez, +5 authors, J Scott Bryson.
Am J Physiol Gastrointest Liver Physiol, 2010 Jul 17; 299(3). PMID: 20634434    Free PMC article.
Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification.
Eric L Campbell, Christopher F MacManus, +6 authors, Sean P Colgan.
Proc Natl Acad Sci U S A, 2010 Jul 28; 107(32). PMID: 20660763    Free PMC article.
Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats.
Valentina Vasina, Massimiliano Broccoli, +5 authors, Fabrizio De Ponti.
World J Gastroenterol, 2010 Aug 03; 16(29). PMID: 20677336    Free PMC article.
An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.
Mark Asquith, Fiona Powrie.
J Exp Med, 2010 Aug 04; 207(8). PMID: 20679404    Free PMC article.
Review.
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.
Alexander A Chumanevich, Deepak Poudyal, +4 authors, Lorne J Hofseth.
Carcinogenesis, 2010 Aug 07; 31(10). PMID: 20688834    Free PMC article.
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.
Rena Feinman, Edwin A Deitch, +14 authors, Da-Zhong Xu.
Am J Physiol Gastrointest Liver Physiol, 2010 Aug 07; 299(4). PMID: 20689059    Free PMC article.
Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis.
Kai Fang, Megan Bruce, +4 authors, Christopher G Kevil.
Physiol Genomics, 2010 Oct 07; 43(1). PMID: 20923862    Free PMC article.
Ulcerative typhlocolitis associated with Helicobacter mastomyrinus in telomerase-deficient mice.
K A Eaton, J S Opp, +2 authors, V B Young.
Vet Pathol, 2010 Oct 12; 48(3). PMID: 20926734    Free PMC article.
Genes and environment: how will our concepts on the pathophysiology of IBD develop in the future?
Arthur Kaser, Sebastian Zeissig, Richard S Blumberg.
Dig Dis, 2010 Oct 12; 28(3). PMID: 20926863    Free PMC article.
Review.
SHIP deficiency causes Crohn's disease-like ileitis.
William G Kerr, Mi-Young Park, Monique Maubert, Robert W Engelman.
Gut, 2010 Oct 14; 60(2). PMID: 20940287    Free PMC article.
Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis.
Xuan-Zheng Shi, John H Winston, Sushil K Sarna.
Am J Physiol Gastrointest Liver Physiol, 2010 Oct 16; 300(1). PMID: 20947704    Free PMC article.
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
Maximilian J Waldner, Stefan Wirtz, +8 authors, Markus F Neurath.
J Exp Med, 2010 Nov 26; 207(13). PMID: 21098094    Free PMC article.
Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes.
John He Nash, Andre Villegas, +7 authors, Brian K Coombes.
BMC Genomics, 2010 Nov 27; 11. PMID: 21108814    Free PMC article.
Anti-adhesion molecule therapy for inflammatory bowel disease.
Subrata Ghosh, Remo Panaccione.
Therap Adv Gastroenterol, 2010 Dec 25; 3(4). PMID: 21180606    Free PMC article.
Identification of urinary biomarkers of colon inflammation in IL10-/- mice using Short-Column LCMS metabolomics.
Don Otter, Mingshu Cao, +4 authors, Daryl Rowan.
J Biomed Biotechnol, 2010 Dec 29; 2011. PMID: 21188174    Free PMC article.
Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis.
David Philippe, Laurent Favre, +7 authors, Stéphanie Blum.
World J Gastroenterol, 2011 Jan 29; 17(4). PMID: 21274375    Free PMC article.
Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid.
Mansour Mohamadzadeh, Erika A Pfeiler, +11 authors, Todd R Klaenhammer.
Proc Natl Acad Sci U S A, 2011 Feb 02; 108 Suppl 1. PMID: 21282652    Free PMC article.
Highly Cited.
The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice.
Joshua D Wermers, Eoin N McNamee, +2 authors, Jesús Rivera-Nieves.
Gastroenterology, 2011 Feb 09; 140(5). PMID: 21300065    Free PMC article.
Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies.
Iurii Koboziev, Fridrik Karlsson, Songlin Zhang, Matthew B Grisham.
Inflamm Bowel Dis, 2011 Feb 12; 17(5). PMID: 21312318    Free PMC article.
Review.
Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur".
Warren Strober.
J Clin Invest, 2011 Feb 23; 121(3). PMID: 21339637    Free PMC article.
Role of TNFR-related 2 mediated immune responses in dextran sulfate sodium-induced inflammatory bowel disease.
Woon-Ki Kim, Jin-Soo Park, +7 authors, Choon-Soo Jeong.
Mol Cells, 2011 Feb 25; 31(2). PMID: 21347711    Free PMC article.
Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice.
C Alam, E Bittoun, +6 authors, A Hänninen.
Diabetologia, 2011 Mar 08; 54(6). PMID: 21380595
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.
Jianxin Fu, Bo Wei, +14 authors, Lijun Xia.
J Clin Invest, 2011 Mar 09; 121(4). PMID: 21383503    Free PMC article.
Highly Cited.
Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.
Jiang-Hu Piao, Mizuho Hasegawa, +6 authors, Hiroyasu Nakano.
J Biol Chem, 2011 Mar 12; 286(20). PMID: 21393251    Free PMC article.
Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology.
Manolis Roulis, Maria Armaka, +2 authors, George Kollias.
Proc Natl Acad Sci U S A, 2011 Mar 16; 108(13). PMID: 21402942    Free PMC article.
Small molecule tyrosine kinase inhibitors for the treatment of intestinal inflammation.
Maninder Sidhu, Carmen Alonso Cotoner, +6 authors, Hans-Christian Reinecker.
Inflamm Bowel Dis, 2011 Mar 26; 17(12). PMID: 21438094    Free PMC article.
Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations.
Jochen Maul, Martin Zeitz.
Langenbecks Arch Surg, 2011 Apr 12; 397(1). PMID: 21479621
Review.
An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling.
Douglas J Kominsky, Simon Keely, +6 authors, Sean P Colgan.
J Immunol, 2011 Apr 26; 186(11). PMID: 21515785    Free PMC article.
Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis.
Jiangnan Xu, Yu Yang, +5 authors, Yaozhong Ding.
J Immunol, 2011 Apr 29; 186(11). PMID: 21525389    Free PMC article.
Importance of innate mucosal immunity and the promises it holds.
Abhisek Dwivedy, Palok Aich.
Int J Gen Med, 2011 May 11; 4. PMID: 21556316    Free PMC article.
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury.
Sylvain Normand, Anne Delanoye-Crespin, +6 authors, Mathias Chamaillard.
Proc Natl Acad Sci U S A, 2011 May 20; 108(23). PMID: 21593405    Free PMC article.
Highly Cited.
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity.
Peter J Morrison, Sarah J Ballantyne, Marika C Kullberg.
Immunology, 2011 Jun 03; 133(4). PMID: 21631495    Free PMC article.
Review.
Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response.
Y Yang, H Wang, +11 authors, Y Li.
Clin Exp Immunol, 2011 Jun 15; 165(3). PMID: 21668898    Free PMC article.
GREEN TEA POLYPHENOLS MEDIATED APOPTOSIS IN INTESTINAL EPITHELIAL CELLS BY A FADD-DEPENDENT PATHWAY.
Helieh S Oz, Jeffrey L Ebersole.
J Cancer Ther, 2011 Jun 21; 1(3). PMID: 21687829    Free PMC article.
The immunomodulatory properties of viable Lactobacillus salivarius ssp. salivarius CECT5713 are not restricted to the large intestine.
Belén Arribas, Natividad Garrido-Mesa, +10 authors, Julio Gálvez.
Eur J Nutr, 2011 Jun 21; 51(3). PMID: 21688122
The starting lineup: key microbial players in intestinal immunity and homeostasis.
Nicola C Reading, Dennis L Kasper.
Front Microbiol, 2011 Jul 23; 2. PMID: 21779278    Free PMC article.
Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.
Valentin Galitovskiy, Jing Qian, +4 authors, Sergei A Grando.
J Immunol, 2011 Jul 26; 187(5). PMID: 21784975    Free PMC article.
Role of resveratrol-induced CD11b(+) Gr-1(+) myeloid derived suppressor cells (MDSCs) in the reduction of CXCR3(+) T cells and amelioration of chronic colitis in IL-10(-/-) mice.
Udai P Singh, Narendra P Singh, +5 authors, Prakash S Nagarkatti.
Brain Behav Immun, 2011 Aug 03; 26(1). PMID: 21807089    Free PMC article.
Interleukin 37 expression protects mice from colitis.
Eóin N McNamee, Joanne C Masterson, +8 authors, Jesús Rivera-Nieves.
Proc Natl Acad Sci U S A, 2011 Aug 30; 108(40). PMID: 21873195    Free PMC article.
Highly Cited.
Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice.
Maximilian J Waldner, Stefan Wirtz, +2 authors, Markus F Neurath.
Nat Protoc, 2011 Sep 03; 6(9). PMID: 21886109
Impaired peripheral Th1 CD4+ T cell response to Escherichia coli proteins in patients with Crohn's disease and ankylosing spondylitis.
Asgar Ergin, Uta Syrbe, +6 authors, Joachim Sieper.
J Clin Immunol, 2011 Sep 09; 31(6). PMID: 21901394
Intestinal inflammation and colorectal cancer: a double-edged sword?
Angelamaria Rizzo, Francesco Pallone, Giovanni Monteleone, Massimo Claudio Fantini.
World J Gastroenterol, 2011 Sep 14; 17(26). PMID: 21912451    Free PMC article.
Review.
A gut feeling about murine syngeneic GVHD.
J Scott Bryson, J Anthony Brandon, C Darrell Jennings, Alan M Kaplan.
Chimerism, 2011 Sep 14; 2(2). PMID: 21912721    Free PMC article.
Endogenous prion protein attenuates experimentally induced colitis.
Gary R Martin, Catherine M Keenan, Keith A Sharkey, Frank R Jirik.
Am J Pathol, 2011 Sep 20; 179(5). PMID: 21924230    Free PMC article.
Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARδ in inflammation-induced colon carcinogenesis.
Jennifer M Monk, Wooki Kim, +8 authors, Robert S Chapkin.
Am J Physiol Gastrointest Liver Physiol, 2011 Sep 24; 302(1). PMID: 21940900    Free PMC article.
LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages.
Kristen N Bushell, Susan E Leeman, +5 authors, Salomon Amar.
PLoS One, 2011 Oct 11; 6(9). PMID: 21984950    Free PMC article.
Inflammasomes in intestinal inflammation and cancer.
Grace Y Chen, Gabriel Núñez.
Gastroenterology, 2011 Oct 19; 141(6). PMID: 22005480    Free PMC article.
Review.
Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger.
Charlotte E Egan, Sara B Cohen, Eric Y Denkers.
Immunol Cell Biol, 2011 Nov 09; 90(7). PMID: 22064707    Free PMC article.
Review.
Th17-related cytokines: new players in the control of chronic intestinal inflammation.
Ivan Monteleone, Francesco Pallone, Giovanni Monteleone.
BMC Med, 2011 Nov 16; 9. PMID: 22082127    Free PMC article.
Review.
Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice.
Fang Yan, Lihong Wang, +10 authors, D Brent Polk.
Am J Physiol Gastrointest Liver Physiol, 2011 Dec 17; 302(5). PMID: 22173918    Free PMC article.
Re-establishing immunological self-tolerance in autoimmune disease.
Shimon Sakaguchi, Fiona Powrie, Richard M Ransohoff.
Nat Med, 2012 Jan 10; 18(1). PMID: 22227673
The N-terminal fragment of chromogranin A, vasostatin-1 protects mice from acute or chronic colitis upon oral administration.
Cristiano Rumio, Giuseppina F Dusio, +4 authors, Angelo Corti.
Dig Dis Sci, 2012 Jan 27; 57(5). PMID: 22278339
A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: anti-inflammatory and proapoptotic mechanisms.
Deepak Poudyal, Phuong Mai Le, +8 authors, Lorne J Hofseth.
Cancer Prev Res (Phila), 2012 Feb 02; 5(4). PMID: 22293630    Free PMC article.
New insights into the immunological changes in IL-10-deficient mice during the course of spontaneous inflammation in the gut mucosa.
Ana Cristina Gomes-Santos, Thais Garcias Moreira, +7 authors, Ana Maria Caetano Faria.
Clin Dev Immunol, 2012 Mar 09; 2012. PMID: 22400037    Free PMC article.
Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid.
Mojgan Zadeh, Mohammad W Khan, +4 authors, Mansour Mohamadzadeh.
J Inflamm (Lond), 2012 Mar 20; 9. PMID: 22423982    Free PMC article.
Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis.
Morgana T L Castelo-Branco, Igor D P Soares, +11 authors, Heitor S P Souza.
PLoS One, 2012 Mar 21; 7(3). PMID: 22432015    Free PMC article.
Microbial exposure during early life has persistent effects on natural killer T cell function.
Torsten Olszak, Dingding An, +8 authors, Richard S Blumberg.
Science, 2012 Mar 24; 336(6080). PMID: 22442383    Free PMC article.
Highly Cited.
Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells.
J Magarian Blander, Miriam B Torchinsky, Laura Campisi.
Immunol Res, 2012 Mar 31; 54(1-3). PMID: 22460741    Free PMC article.
Review.
Emergence of T cells that recognize nonpolymorphic antigens during graft-versus- host disease.
Hemalatha Rangarajan, Maryam Yassai, +4 authors, William R Drobyski.
Blood, 2012 Apr 13; 119(26). PMID: 22496151    Free PMC article.
Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease.
Thomas Lindebo Holm, Steen Seier Poulsen, Helle Markholst, Stine Reedtz-Runge.
Int J Inflam, 2012 Apr 27; 2012. PMID: 22536543    Free PMC article.
Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13.
Ana Camelo, Jillian L Barlow, +8 authors, Andrew N J McKenzie.
J Gastroenterol, 2012 Apr 28; 47(11). PMID: 22539101    Free PMC article.
Loss of TMF/ARA160 protein renders colonic mucus refractory to bacterial colonization and diminishes intestinal susceptibility to acute colitis.
Shai Bel, Yoav Elkis, +3 authors, Uri Nir.
J Biol Chem, 2012 May 04; 287(30). PMID: 22553199    Free PMC article.
Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer.
Deborah C Rubin, Anisa Shaker, Marc S Levin.
Front Immunol, 2012 May 16; 3. PMID: 22586430    Free PMC article.
Highly Cited.
Lineage targeted MHC-II transgenic mice demonstrate the role of dendritic cells in bacterial-driven colitis.
Lillian Maggio-Price, Audrey Seamons, +5 authors, Robert M Hershberg.
Inflamm Bowel Dis, 2012 May 24; 19(1). PMID: 22619032    Free PMC article.
Oral treatment with Hev b 13 ameliorates experimental colitis in mice.
L B Teixeira, V L A A Epifânio, +2 authors, J Coutinho-Netto.
Clin Exp Immunol, 2012 Jun 08; 169(1). PMID: 22670775    Free PMC article.
Microbiota, disease, and back to health: a metastable journey.
Richard Blumberg, Fiona Powrie.
Sci Transl Med, 2012 Jun 08; 4(137). PMID: 22674557    Free PMC article.
Highly Cited. Review.
New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation.
Giorgos Bamias, Daniele Corridoni, Theresa T Pizarro, Fabio Cominelli.
Cytokine, 2012 Jul 17; 59(3). PMID: 22795953    Free PMC article.
Review.
Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases.
William A Rose, Kaori Sakamoto, Cynthia A Leifer.
BMC Immunol, 2012 Aug 03; 13. PMID: 22853702    Free PMC article.
Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.
Cortez McBerry, Charlotte E Egan, +10 authors, De'broski R Herbert.
J Immunol, 2012 Aug 17; 189(6). PMID: 22896633    Free PMC article.
A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs.
Naoki Kashimoto, Satomi Ishii, +3 authors, Hiromitsu Watanabe.
Oncol Lett, 2010 Jan 01; 1(1). PMID: 22966257    Free PMC article.
Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections.
Staci Kearney, Christine Delgado, Laurel L Lenz.
Immunol Res, 2012 Sep 18; 55(1-3). PMID: 22983898    Free PMC article.
Review.
Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium.
Hana Yamaguchi, Kenji Suzuki, +11 authors, Ritsuo Takagi.
Med Mol Morphol, 2012 Sep 25; 45(3). PMID: 23001296
Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis.
V Valatas, J He, +3 authors, B L Kelsall.
Mucosal Immunol, 2012 Nov 15; 6(3). PMID: 23149660    Free PMC article.
Role of Smad7 in inflammatory bowel diseases.
Giovanni Monteleone, Roberta Caruso, Francesco Pallone.
World J Gastroenterol, 2012 Nov 17; 18(40). PMID: 23155305    Free PMC article.
Review.
A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity.
Jacqueline M Leung, P'ng Loke.
Int J Parasitol, 2012 Nov 28; 43(3-4). PMID: 23178750    Free PMC article.
Review.
Opposite role of tumor necrosis factor receptors in dextran sulfate sodium-induced colitis in mice.
Ke Wang, Gencheng Han, +11 authors, Guojiang Chen.
PLoS One, 2013 Jan 04; 7(12). PMID: 23285227    Free PMC article.
GM-CSF produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa.
Laia Egea, Christopher S McAllister, +3 authors, Martin F Kagnoff.
J Immunol, 2013 Jan 18; 190(4). PMID: 23325885    Free PMC article.
Soybean β-conglycinin induces inflammation and oxidation and causes dysfunction of intestinal digestion and absorption in fish.
Jin-Xiu Zhang, Lin-Ying Guo, +8 authors, Xiao-Qiu Zhou.
PLoS One, 2013 Mar 23; 8(3). PMID: 23520488    Free PMC article.
Nutritional protective mechanisms against gut inflammation.
Monica Viladomiu, Raquel Hontecillas, +2 authors, Josep Bassaganya-Riera.
J Nutr Biochem, 2013 Apr 02; 24(6). PMID: 23541470    Free PMC article.
Review.
The unfolded protein response and gastrointestinal disease.
Arthur Kaser, Timon Erik Adolph, Richard S Blumberg.
Semin Immunopathol, 2013 Apr 17; 35(3). PMID: 23588234    Free PMC article.
Review.
The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium.
Sabine Kersting, Volker Behrendt, +7 authors, Ansgar M Chromik.
J Inflamm Res, 2013 May 15; 6. PMID: 23667316    Free PMC article.
The Effects of Rheum Tanguticum Polysaccharide on the Polarization of Th1 and Th2 Cells in TNBS-Induced Colitis in Murine.
Li Liu, Qi-Bing Mei, +4 authors, Jia-Yun Liu.
Int J Biomed Sci, 2005 Jun 01; 1(1). PMID: 23674951    Free PMC article.
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis.
John H Winston, Qingjie Li, Sushil K Sarna.
Am J Physiol Gastrointest Liver Physiol, 2013 May 18; 305(4). PMID: 23681475    Free PMC article.
Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases.
Gu-Jiun Lin, Shing-Hwa Huang, +3 authors, Huey-Kang Sytwu.
Int J Mol Sci, 2013 Jun 04; 14(6). PMID: 23727938    Free PMC article.
Review.
Changes in the expression of smooth muscle contractile proteins in TNBS- and DSS-induced colitis in mice.
Reem Alkahtani, Sunila Mahavadi, +3 authors, Karnam S Murthy.
Inflammation, 2013 Jun 25; 36(6). PMID: 23794034    Free PMC article.
Colitis and colon cancer in WASP-deficient mice require helicobacter species.
Deanna D Nguyen, Suresh Muthupalani, +7 authors, James G Fox.
Inflamm Bowel Dis, 2013 Jul 04; 19(10). PMID: 23820270    Free PMC article.
Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis.
Colm B Collins, Carol M Aherne, +9 authors, Jesús Rivera-Nieves.
Inflamm Bowel Dis, 2013 Jul 10; 19(9). PMID: 23835442    Free PMC article.
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.
Koji Atarashi, Takeshi Tanoue, +19 authors, Kenya Honda.
Nature, 2013 Jul 12; 500(7461). PMID: 23842501
Highly Cited.
Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following acetic acid induced intestinal injury in rats.
Forat Swaid, Igor Sukhotnik, +4 authors, Alexandra Lavy.
Nutr Metab (Lond), 2013 Aug 08; 10. PMID: 23919638    Free PMC article.
Aryl hydrocarbon receptor and colitis.
Ivan Monteleone, Francesco Pallone, Giovanni Monteleone.
Semin Immunopathol, 2013 Aug 10; 35(6). PMID: 23928874
Review.
Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice.
S M Blois, G Sulkowski, +7 authors, G S Dveksler.
Mucosal Immunol, 2013 Aug 16; 7(2). PMID: 23945545    Free PMC article.
Angiotensin converting enzyme-inhibitor reduces colitis severity in an IL-10 knockout model.
Ryo Sueyoshi, Kathleen M Woods Ignatoski, +2 authors, Daniel H Teitelbaum.
Dig Dis Sci, 2013 Aug 21; 58(11). PMID: 23949641    Free PMC article.
Impact of the gut microbiome on mucosal inflammation.
Warren Strober.
Trends Immunol, 2013 Aug 21; 34(9). PMID: 23957963    Free PMC article.
Review.
Impact of interleukin-10 gene polymorphisms on survival in patients with colorectal cancer.
Wen-Chien Ting, Lu-Min Chen, +6 authors, Bo-Ying Bao.
J Korean Med Sci, 2013 Sep 10; 28(9). PMID: 24015034    Free PMC article.
Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state.
Ke Zen, Yalan Guo, +5 authors, Yuan Liu.
Nat Commun, 2013 Sep 13; 4. PMID: 24026300    Free PMC article.
Effects of sinomenine on the expression of microRNA-155 in 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice.
Qiao Yu, Siying Zhu, +6 authors, Bing Xia.
PLoS One, 2013 Sep 26; 8(9). PMID: 24066068    Free PMC article.
Intestinal epithelium and autophagy: partners in gut homeostasis.
Sarron Randall-Demllo, Marcello Chieppa, Rajaraman Eri.
Front Immunol, 2013 Oct 19; 4. PMID: 24137160    Free PMC article.
Review.
Immune cells: plastic players along colorectal cancer progression.
Giuseppe Di Caro, Federica Marchesi, Luigi Laghi, Fabio Grizzi.
J Cell Mol Med, 2013 Oct 25; 17(9). PMID: 24151976    Free PMC article.
Review.
Acquisition of Genetic Aberrations by Activation-Induced Cytidine Deaminase (AID) during Inflammation-Associated Carcinogenesis.
Atsushi Takai, Hiroyuki Marusawa, Tsutomu Chiba.
Cancers (Basel), 2011 Jan 01; 3(2). PMID: 24212831    Free PMC article.
Effect of salicin on gut inflammation and on selected groups of gut microbiota in dextran sodium sulfate induced mouse model of colitis.
Nirmal Verma, Ravi Verma, +2 authors, Jaishree Paul.
Inflamm Res, 2013 Nov 19; 63(2). PMID: 24240229
Autoantibodies and an immune-based rat model of inflammatory bowel disease.
Hadi Esmaily, Yara Sanei, Mohammad Abdollahi.
World J Gastroenterol, 2013 Nov 28; 19(43). PMID: 24282347    Free PMC article.
Review.
Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis.
Jing Xiong, Ying-Hao Lin, +3 authors, Si-De Liu.
BMC Gastroenterol, 2013 Dec 10; 13. PMID: 24314293    Free PMC article.
IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia.
Douglas J Kominsky, Eric L Campbell, +12 authors, Dunja Bruder.
J Immunol, 2013 Dec 25; 192(3). PMID: 24367025    Free PMC article.
Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis.
Hua-Ying Fan, Zi-Liang Zhang, +5 authors, Wei-Wei Song.
World J Gastroenterol, 2014 Jan 11; 19(48). PMID: 24409058    Free PMC article.
Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases.
Rajeev K Pandey, Fu-Shin Yu, Ashok Kumar.
Indian J Med Res, 2014 Jan 18; 138(5). PMID: 24434316    Free PMC article.
Review.
Heat-killed VSL#3 ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in rats.
Li-Xuan Sang, Bing Chang, +3 authors, Min Jiang.
Int J Mol Sci, 2014 Jan 24; 15(1). PMID: 24451125    Free PMC article.
Efficacy of topical versus oral 5-aminosalicylate for treatment of 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats.
Jin Li, Cheng Chen, +3 authors, Jing Wang.
J Huazhong Univ Sci Technolog Med Sci, 2014 Feb 06; 34(1). PMID: 24496680
In vivo femtosecond endosurgery: an intestinal epithelial regeneration-after-injury model.
Myunghwan Choi, Seok Hyun Yun.
Opt Express, 2014 Feb 12; 21(25). PMID: 24514657    Free PMC article.
Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).
M Sałaga, A Mokrowiecka, +10 authors, J Fichna.
J Crohns Colitis, 2014 Feb 18; 8(9). PMID: 24530133    Free PMC article.
Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation.
Wei Wu, Mingming Sun, +9 authors, Ping-Chang Yang.
Gut, 2014 Feb 20; 63(12). PMID: 24550371    Free PMC article.
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.
Frann Antignano, Kyle Burrows, +16 authors, Colby Zaph.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667637    Free PMC article.
Oral administration of bovine milk from cows hyperimmunized with intestinal bacterin stimulates lamina propria T lymphocytes to produce Th1-biased cytokines in mice.
Yuanyuan Wang, Lianjie Lin, +5 authors, Yasunobu Yoshikai.
Int J Mol Sci, 2014 Apr 02; 15(4). PMID: 24686517    Free PMC article.
Cytokines in inflammatory bowel disease.
Markus F Neurath.
Nat Rev Immunol, 2014 Apr 23; 14(5). PMID: 24751956
Highly Cited. Review.
A Probiotic Preparation Duolac-Gold Ameliorates Dextran Sulphate Sodium-induced Mouse Colitis by Downregulating the Expression of IL-6.
Hyunho Yoon, Yeo-Sang Yoon, +2 authors, Do-Young Yum.
Toxicol Res, 2014 May 06; 30(1). PMID: 24795796    Free PMC article.
IL-21 induces IL-22 production in CD4+ T cells.
Ada Yeste, Ivan D Mascanfroni, +7 authors, Francisco J Quintana.
Nat Commun, 2014 May 07; 5. PMID: 24796415    Free PMC article.
Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers.
L Mira-Pascual, R Cabrera-Rubio, +7 authors, M C Collado.
J Gastroenterol, 2014 May 09; 50(2). PMID: 24811328
Highly Cited.
Critical roles of TIPE2 protein in murine experimental colitis.
Yunwei Lou, Honghong Sun, +4 authors, Youhai H Chen.
J Immunol, 2014 Jun 29; 193(3). PMID: 24973456    Free PMC article.
Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells.
Elizabeth R Mann, Xuhang Li.
World J Gastroenterol, 2014 Aug 12; 20(29). PMID: 25110405    Free PMC article.
Review.
Gadolinium chloride improves the course of TNBS and DSS-induced colitis through protecting against colonic mucosal inflammation.
Chao Du, Peng Wang, +3 authors, Yanqing Li.
Sci Rep, 2014 Aug 26; 4. PMID: 25146101    Free PMC article.
Differential regulation of proinflammatory cytokine expression by mitogen-activated protein kinases in macrophages in response to intestinal parasite infection.
Mei Xing Lim, Chin Wen Png, +5 authors, Yongliang Zhang.
Infect Immun, 2014 Aug 27; 82(11). PMID: 25156742    Free PMC article.
A guide to histomorphological evaluation of intestinal inflammation in mouse models.
Ulrike Erben, Christoph Loddenkemper, +6 authors, Anja A Kühl.
Int J Clin Exp Pathol, 2014 Sep 10; 7(8). PMID: 25197329    Free PMC article.
Highly Cited.
Regional specialization within the intestinal immune system.
Allan M Mowat, William W Agace.
Nat Rev Immunol, 2014 Sep 23; 14(10). PMID: 25234148
Highly Cited. Review.
Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.
Rita Aldini, Matteo Micucci, +14 authors, Roberta Budriesi.
PLoS One, 2014 Oct 01; 9(9). PMID: 25268769    Free PMC article.
Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis.
Zi-Liang Zhang, Hua-Ying Fan, +2 authors, Ke Liu.
World J Gastroenterol, 2014 Nov 12; 20(41). PMID: 25386079    Free PMC article.
Role of viruses and bacteria-virus interactions in autoimmunity.
Ashley L Steed, Thaddeus S Stappenbeck.
Curr Opin Immunol, 2014 Dec 03; 31. PMID: 25459001    Free PMC article.
Review.
Hydrolysate from eggshell membrane ameliorates intestinal inflammation in mice.
Yaning Shi, Prithy Rupa, Bo Jiang, Yoshinori Mine.
Int J Mol Sci, 2014 Dec 17; 15(12). PMID: 25501329    Free PMC article.
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
Linh P Nguyen, Junliang Pan, +9 authors, Aida Habtezion.
Nat Immunol, 2014 Dec 23; 16(2). PMID: 25531831    Free PMC article.
Azilsartan reduced TNF-α and IL-1β levels, increased IL-10 levels and upregulated VEGF, FGF, KGF, and TGF-α in an oral mucositis model.
Aurigena Antunes de Araújo, Hugo Varela, +4 authors, Raimundo Fernandes de Araújo Júnior.
PLoS One, 2015 Feb 18; 10(2). PMID: 25689279    Free PMC article.
Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine.
Daehee Han, Matthew C Walsh, +6 authors, Yongwon Choi.
PLoS One, 2015 Feb 18; 10(2). PMID: 25689829    Free PMC article.
Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.
Oscar Sasso, Marco Migliore, +6 authors, Daniele Piomelli.
FASEB J, 2015 Mar 12; 29(6). PMID: 25757568    Free PMC article.
Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease.
Yava L Jones-Hall, Ariangela Kozik, Cindy Nakatsu.
PLoS One, 2015 Mar 17; 10(3). PMID: 25775453    Free PMC article.
The application of RNAi-based treatments for inflammatory bowel disease.
Morten Tobias Jarlstad Olesen, Borja Ballarín-González, Kenneth Alan Howard.
Drug Deliv Transl Res, 2015 Mar 20; 4(1). PMID: 25786614
Phytogenic compounds as alternatives to in-feed antibiotics: potentials and challenges in application.
Chengbo Yang, M A Kabir Chowdhury, Yongqing Huo, Joshua Gong.
Pathogens, 2015 Mar 26; 4(1). PMID: 25806623    Free PMC article.
Review.
Crotoxin from Crotalus durissus terrificus is able to down-modulate the acute intestinal inflammation in mice.
Caroline de Souza Almeida, Vinicius Andrade-Oliveira, +2 authors, Eliana L Faquim-Mauro.
PLoS One, 2015 Apr 09; 10(4). PMID: 25853847    Free PMC article.
Chronic intestinal inflammation alters hippocampal neurogenesis.
Svetlana Zonis, Robert N Pechnick, +4 authors, Vera Chesnokova.
J Neuroinflammation, 2015 Apr 19; 12. PMID: 25889852    Free PMC article.
The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.
Hai-Sheng Zhang, Ying Chen, +13 authors, Jing Fang.
J Biol Chem, 2015 May 01; 290(24). PMID: 25925952    Free PMC article.
Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.
Mehari Endale, H Ibrahim Aksoylar, Kasper Hoebe.
Mediators Inflamm, 2015 May 07; 2015. PMID: 25944983    Free PMC article.
Review.
High Incubation Temperature and Threonine Dietary Level Improve Ileum Response Against Post-Hatch Salmonella Enteritidis Inoculation in Broiler Chicks.
Alexandre Lemos de Barros Moreira Filho, Celso José Bruno de Oliveira, +4 authors, Patricia Emília Naves Givisiez.
PLoS One, 2015 Jul 02; 10(7). PMID: 26131553    Free PMC article.
Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner.
Dagmar Srutkova, Martin Schwarzer, +6 authors, Irma Schabussova.
PLoS One, 2015 Jul 29; 10(7). PMID: 26218526    Free PMC article.
A Saudi Gastroenterology association position statement on the use of tumor necrosis factor-alfa antagonists for the treatment of inflammatory bowel disease.
Mahmoud H Mosli, Othman Al-Harbi, Brian G Feagan, Majid A Almadi.
Saudi J Gastroenterol, 2015 Aug 01; 21(4). PMID: 26228361    Free PMC article.
Maternal and neonatal dietary intake of balanced n-6/n-3 fatty acids modulates experimental colitis in young adult rats.
K Vijay Kumar Reddy, K Akhilender Naidu.
Eur J Nutr, 2015 Aug 08; 55(5). PMID: 26246200
CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis.
Svetlana F Khaiboullina, Aigul R Gumerova, +4 authors, Albert A Rizvanov.
Biomed Res Int, 2015 Aug 22; 2015. PMID: 26295034    Free PMC article.
Dietary Mannan Oligosaccharides: Counteracting the Side Effects of Soybean Meal Oil Inclusion on European Sea Bass (Dicentrarchus labrax) Gut Health and Skin Mucosa Mucus Production?
Silvia Torrecillas, Daniel Montero, +5 authors, Marisol Izquierdo.
Front Immunol, 2015 Aug 25; 6. PMID: 26300883    Free PMC article.
Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease.
Judith R Kelsen, Robert N Baldassano, David Artis, Gregory F Sonnenberg.
Cell Mol Gastroenterol Hepatol, 2015 Sep 24; 1(5). PMID: 26393237    Free PMC article.
A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates.
Sarel J Brand, Marisa Moller, Brian H Harvey.
Curr Neuropharmacol, 2015 Sep 29; 13(3). PMID: 26411964    Free PMC article.
Review.
The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice.
Liesbeth Allais, Smitha Kumar, +11 authors, Ken R Bracke.
PLoS One, 2015 Nov 03; 10(11). PMID: 26523550    Free PMC article.
Mycophenolate Mofetil Modulates Differentiation of Th1/Th2 and the Secretion of Cytokines in an Active Crohn's Disease Mouse Model.
Qing-Kang Lv, Ju-Xiong Liu, +9 authors, Wei Wang.
Int J Mol Sci, 2015 Nov 13; 16(11). PMID: 26561804    Free PMC article.
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
Gabriela Tejón, Valeria Manríquez, +8 authors, Mario Rosemblatt.
Biomed Res Int, 2015 Nov 20; 2015. PMID: 26583087    Free PMC article.
Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.
Woo-Jeong Shon, Young-Kwan Lee, +2 authors, Dong-Mi Shin.
Sci Rep, 2015 Nov 28; 5. PMID: 26610689    Free PMC article.
New Signaling Pathway for Gut-Brain Interactions.
Vera Chesnokova, Robert N Pechnick.
Neuropsychopharmacology, 2015 Dec 15; 41(1). PMID: 26657951    Free PMC article.
Review.
An experimental model of colitis induced by dextran sulfate sodium from acute progresses to chronicity in C57BL/6: correlation between conditions of mice and the environment.
Niloofar Taghipour, Mahsa Molaei, +5 authors, Mohammad Reza Zali.
Gastroenterol Hepatol Bed Bench, 2016 Jan 09; 9(1). PMID: 26744614    Free PMC article.
Chronic peripheral inflammation, hippocampal neurogenesis, and behavior.
Vera Chesnokova, Robert N Pechnick, Kolja Wawrowsky.
Brain Behav Immun, 2016 Jan 24; 58. PMID: 26802985    Free PMC article.
Review.
The Importance of Intestinal Eotaxin-1 in Inflammatory Bowel Disease: New Insights and Possible Therapeutic Implications.
Tomer Adar, Shimon Shteingart, +7 authors, Eran Goldin.
Dig Dis Sci, 2016 Feb 15; 61(7). PMID: 26874691
Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis.
Liraz Shmuel-Galia, Tegest Aychek, +6 authors, Yechiel Shai.
EMBO J, 2016 Feb 18; 35(6). PMID: 26884587    Free PMC article.
The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.
Agnieszka M Kabat, Oliver J Harrison, +10 authors, Kevin J Maloy.
Elife, 2016 Feb 26; 5. PMID: 26910010    Free PMC article.
Highly Cited.
The Intersection of TNF, IBD and the Microbiome.
Yava L Jones-Hall, Cindy H Nakatsu.
Gut Microbes, 2016 Mar 05; 7(1). PMID: 26939853    Free PMC article.
Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis.
Bojana Simovic Markovic, Aleksandar Nikolic, +6 authors, Vladislav Volarevic.
Stem Cells Int, 2016 Apr 09; 2016. PMID: 27057168    Free PMC article.
Current Understanding of Dysbiosis in Disease in Human and Animal Models.
Arianna K DeGruttola, Daren Low, Atsushi Mizoguchi, Emiko Mizoguchi.
Inflamm Bowel Dis, 2016 Apr 14; 22(5). PMID: 27070911    Free PMC article.
Highly Cited. Review.
Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis.
Hyun Jung Lee, Sun-Hee Oh, +8 authors, Won Ho Kim.
Gut Liver, 2016 Apr 27; 10(3). PMID: 27114436    Free PMC article.
Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation.
Haidar Shamran, Narendra P Singh, +8 authors, Udai P Singh.
Brain Behav Immun, 2016 Jun 22; 59. PMID: 27327245    Free PMC article.
Short-Term Surveillance of Cytokines and C-Reactive Protein Cannot Predict Efficacy of Fecal Microbiota Transplantation for Ulcerative Colitis.
Ting Zhang, Bota Cui, +6 authors, Faming Zhang.
PLoS One, 2016 Jun 28; 11(6). PMID: 27347881    Free PMC article.
Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways.
Yali Yang, Hui Yan, +7 authors, Lipeng Xu.
Sci Rep, 2016 Jul 21; 6. PMID: 27435110    Free PMC article.
The Algal Meroterpene 11-Hydroxy-1'-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice.
Hanaa Zbakh, Elena Talero, +4 authors, Virginia Motilva.
Mar Drugs, 2016 Aug 17; 14(8). PMID: 27527191    Free PMC article.
NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF-κB subunit c-Rel in Paneth cell-like cells.
Gao Tan, Erbo Liang, +5 authors, Fachao Zhi.
Oncotarget, 2016 Aug 27; 7(39). PMID: 27563808    Free PMC article.
Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells.
Bianca Mendes Souza, Tatiane Melo Preisser, +11 authors, Anderson Miyoshi.
Microb Cell Fact, 2016 Sep 01; 15(1). PMID: 27576902    Free PMC article.
Imiquimod-induced CCR9 Ameliorates murine TNBS Colitis.
Ryoma Suzuki, Kyoko Katakura, +3 authors, Hiromasa Ohira.
Fukushima J Med Sci, 2016 Nov 11; 62(2). PMID: 27829595    Free PMC article.
Induction of Colitis in Young Rats by Dextran Sulfate Sodium.
María Vicario, Mar Crespí, +3 authors, Miquel Moretó.
Dig Dis Sci, 2005 Jan 01; 50(1). PMID: 27837390
Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation.
K Arimura, H Takagi, +6 authors, K Sato.
Mucosal Immunol, 2016 Nov 17; 10(4). PMID: 27848952
Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation.
Shoichiro Kawai, Hideki Iijima, +13 authors, Tetsuo Takehara.
J Gastroenterol, 2016 Dec 03; 52(8). PMID: 27900483
Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating intestinal epithelial cell homeostasis, inflammation and immune response.
Ying Zou, Jiantao Lin, +9 authors, Honggang Chi.
Sci Rep, 2016 Dec 17; 6. PMID: 27982094    Free PMC article.
A lactic acid bacterium isolated from kimchi ameliorates intestinal inflammation in DSS-induced colitis.
Jin-Soo Park, Inseong Joe, +2 authors, Gajin Jeong.
J Microbiol, 2017 Jan 27; 55(4). PMID: 28124779
The Protective Role of Type I Interferons in the Gastrointestinal Tract.
Kevin P Kotredes, Brianna Thomas, Ana M Gamero.
Front Immunol, 2017 Apr 22; 8. PMID: 28428788    Free PMC article.
Review.
Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis.
Larissa Sbaglia Celiberto, Raquel Bedani, +10 authors, Daniela Cardoso Umbelino Cavallini.
PLoS One, 2017 Apr 25; 12(4). PMID: 28437455    Free PMC article.
Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid.
Chih-Tung Chiu, Sheng-Nan Kuo, Shao-Wen Hung, Cheng-Yao Yang.
Molecules, 2017 May 31; 22(6). PMID: 28556814    Free PMC article.
Chemically induced mouse models of acute and chronic intestinal inflammation.
Stefan Wirtz, Vanessa Popp, +4 authors, Markus F Neurath.
Nat Protoc, 2017 Jun 02; 12(7). PMID: 28569761
Highly Cited.
Chronic Inflammatory Diseases and Green Tea Polyphenols.
Helieh S Oz.
Nutrients, 2017 Jun 08; 9(6). PMID: 28587181    Free PMC article.
Review.
Intestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO2 phytopharmaceutical preparation.
Luiz Domingues Almeida Junior, Ana Elisa Valencise Quaglio, Celso Acácio Rodrigues de Almeida Costa, Luiz Claudio Di Stasi.
World J Gastroenterol, 2017 Jul 15; 23(24). PMID: 28706419    Free PMC article.
Proteomics in Inflammatory Bowel Disease: Approach Using Animal Models.
Fadi H Mourad, Yunki Yau, Valerie C Wasinger, Rupert W Leong.
Dig Dis Sci, 2017 Jul 19; 62(9). PMID: 28717845
Review.
Development of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice.
Thomas Sharpton, Svetlana Lyalina, +6 authors, Katherine S Pollard.
mSystems, 2017 Sep 15; 2(5). PMID: 28904997    Free PMC article.
TH17 cells mediate inflammation in a novel model of spontaneous experimental autoimmune lacrimal keratoconjunctivitis with neural damage.
Kyoung Yul Seo, Kazuya Kitamura, Soo Jung Han, Brian Kelsall.
J Allergy Clin Immunol, 2017 Sep 30; 142(1). PMID: 28958903    Free PMC article.
Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis.
Derrick D Eichele, Kusum K Kharbanda.
World J Gastroenterol, 2017 Oct 04; 23(33). PMID: 28970718    Free PMC article.
Highly Cited. Review.
Therapeutic effect of imiquimod on dextran sulfate sodium-induced ulcerative colitis in mice.
Lu Chen, Zhongyin Zhou, +2 authors, Hongyu Xiang.
PLoS One, 2017 Oct 20; 12(10). PMID: 29049372    Free PMC article.
Mesenchymal stromal cells modulate gut inflammation in experimental colitis.
Cristhiane Favero de Aguiar, Angela Castoldi, +6 authors, Danilo Candido de Almeida.
Inflammopharmacology, 2017 Oct 25; 26(1). PMID: 29063489
Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review.
Xiaoshi Ma, Zhaolai Dai, +6 authors, Zhenlong Wu.
Front Immunol, 2017 Nov 10; 8. PMID: 29118753    Free PMC article.
Review.
Preventing disability in inflammatory bowel disease.
Patrick B Allen, Corinne Gower-Rousseau, Silvio Danese, Laurent Peyrin-Biroulet.
Therap Adv Gastroenterol, 2017 Nov 18; 10(11). PMID: 29147137    Free PMC article.
Review.
Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.
Qimeng Wang, Kunqiu Yang, +9 authors, Hua Yang.
Int J Mol Med, 2017 Dec 06; 41(2). PMID: 29207040    Free PMC article.
Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract.
Michael Dougan.
Front Immunol, 2017 Dec 13; 8. PMID: 29230210    Free PMC article.
Highly Cited. Review.
Enteral nutrition combined with glutamine promotes recovery after ileal pouch-anal anastomosis in rats.
Yan-Yan Xu, An-Qi He, +3 authors, Tong Liu.
World J Gastroenterol, 2018 Feb 13; 24(5). PMID: 29434447    Free PMC article.
The cholinergic anti-inflammatory pathway revisited.
K Murray, C Reardon.
Neurogastroenterol Motil, 2018 Feb 23; 30(3). PMID: 29468816    Free PMC article.
Review.
Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches.
Sajid Ur Rahman, Yu Li, +4 authors, Xichun Wang.
Inflammopharmacology, 2018 Mar 14; 26(2). PMID: 29532213
Review.
Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis.
Andrea Mencarelli, Hanif Javanmard Khameneh, +10 authors, Alessandra Mortellaro.
Nat Commun, 2018 Mar 20; 9(1). PMID: 29549257    Free PMC article.
The interplay between microbes and the immune response in inflammatory bowel disease.
Ashleigh Goethel, Kenneth Croitoru, Dana J Philpott.
J Physiol, 2018 May 29; 596(17). PMID: 29806140    Free PMC article.
Review.
Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes.
Xi Shen, Liping Liu, +6 authors, Fang Yan.
Mucosal Immunol, 2018 Jun 08; 11(5). PMID: 29875401    Free PMC article.
Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.
Bing Wei, Ran Zhang, +6 authors, Xun Sun.
J Immunol Res, 2018 Jun 12; 2018. PMID: 29888292    Free PMC article.
Colonic migrating motor complexes are inhibited in acute tri-nitro benzene sulphonic acid colitis.
Ben R Hofma, Hannah R Wardill, +7 authors, Patrick A Hughes.
PLoS One, 2018 Jun 23; 13(6). PMID: 29933379    Free PMC article.
The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis.
A M Overstreet, D L LaTorre, +8 authors, D L Boone.
Mucosal Immunol, 2018 Jul 11; 11(5). PMID: 29988117    Free PMC article.
The surgical treatment of acute and severe diversion colitis mimicking ulcerative colitis: a case report.
Nao Kakizawa, Shingo Tsujinaka, +6 authors, Toshiki Rikiyama.
Surg Case Rep, 2018 Aug 04; 4(1). PMID: 30073476    Free PMC article.
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment.
Moses M Kasembeli, Uddalak Bharadwaj, Prema Robinson, David J Tweardy.
Int J Mol Sci, 2018 Aug 08; 19(8). PMID: 30081609    Free PMC article.
Review.
Neuroimmune Communication in Health and Disease.
Colin Reardon, Kaitlin Murray, Alan E Lomax.
Physiol Rev, 2018 Aug 16; 98(4). PMID: 30109819    Free PMC article.
Review.
Advances in Imaging Specific Mediators of Inflammatory Bowel Disease.
Nicole Dmochowska, Hannah R Wardill, Patrick A Hughes.
Int J Mol Sci, 2018 Aug 24; 19(9). PMID: 30134572    Free PMC article.
Review.
Essential oils as alternatives to antibiotics in swine production.
Faith A Omonijo, Liju Ni, +3 authors, Chengbo Yang.
Anim Nutr, 2018 Aug 25; 4(2). PMID: 30140752    Free PMC article.
Review.
Fecal Microbiota Transplantation Ameliorates Experimentally Induced Colitis in Mice by Upregulating AhR.
Yan-Ling Wei, Yu-Qin Chen, +8 authors, Dong-Feng Chen.
Front Microbiol, 2018 Sep 11; 9. PMID: 30197631    Free PMC article.
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Clara Meana, Ginesa García-Rostán, +6 authors, María A Balboa.
JCI Insight, 2018 Sep 21; 3(18). PMID: 30232275    Free PMC article.
Ginger attenuates inflammation in a mouse model of dextran sulfate sodium-induced colitis.
Min Seo Kim, Ji Yeon Kim.
Food Sci Biotechnol, 2018 Oct 16; 27(5). PMID: 30319860    Free PMC article.
Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis.
Natalia Schneider Nunes, Saejeong Kim, +4 authors, Joseph Alan Frank.
World J Gastroenterol, 2018 Oct 23; 24(38). PMID: 30344419    Free PMC article.
Augmented reduction in colonic inflammatory markers of dextran sulfate sodium-induced colitis with a combination of 5-aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata.
Jaeyoung Cho, Hyuck-Se Kweon, Sung-Oh Huh, Ali Sadra.
Anim Cells Syst (Seoul), 2018 Nov 22; 22(3). PMID: 30460097    Free PMC article.
Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota.
You Jin Jang, Woon-Ki Kim, +2 authors, Gwangpyo Ko.
Gut Microbes, 2019 Apr 04; 10(6). PMID: 30939976    Free PMC article.
Effects of Microcystin-LR on the Microstructure and Inflammation-Related Factors of Jejunum in Mice.
Linghui Cao, Feiyu Huang, +4 authors, Fei Yang.
Toxins (Basel), 2019 Aug 24; 11(9). PMID: 31438657    Free PMC article.
Taraxacum officinale extract ameliorates dextran sodium sulphate-induced colitis by regulating fatty acid degradation and microbial dysbiosis.
Wei Chen, Huining Fan, +3 authors, Jinshui Zhu.
J Cell Mol Med, 2019 Oct 01; 23(12). PMID: 31565850    Free PMC article.
Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain-gut axis.
Kohei Takahashi, Osamu Nakagawasai, +9 authors, Takeshi Tadano.
J Neuroinflammation, 2019 Nov 02; 16(1). PMID: 31672153    Free PMC article.
A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease.
Arno R Bourgonje, Julius Z H von Martels, +12 authors, Gerard Dijkstra.
Front Med (Lausanne), 2019 Nov 28; 6. PMID: 31772929    Free PMC article.
Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine.
Manoj Kumar, Mathieu Garand, Souhaila Al Khodor.
J Transl Med, 2019 Dec 15; 17(1). PMID: 31836022    Free PMC article.
Review.
Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses.
Jan Kevin Maerz, Constanze Trostel, +6 authors, Julia-Stefanie Frick.
Front Immunol, 2020 Feb 11; 10. PMID: 32038631    Free PMC article.
Therapeutic effects of a single injection of human umbilical mesenchymal stem cells on acute and chronic colitis in mice.
Yu-Lung Chang, Huei-Yu Lo, +5 authors, Chin-Kan Chan.
Sci Rep, 2019 Apr 11; 9(1). PMID: 30967579    Free PMC article.
miR-106a deficiency attenuates inflammation in murine IBD models.
Megan R Sanctuary, Rick H Huang, +5 authors, Colm B Collins.
Mucosal Immunol, 2018 Oct 18; 12(1). PMID: 30327532    Free PMC article.
Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles.
Luyao Yang, James N Higginbotham, +6 authors, Fang Yan.
Infect Immun, 2019 Apr 24; 87(7). PMID: 31010817    Free PMC article.
Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms.
Sonia Shastri, Tanvi Shinde, +2 authors, Rajaraman Eri.
Int J Mol Sci, 2020 Jan 17; 21(2). PMID: 31940911    Free PMC article.
The Control of Intestinal Inflammation: A Major Objective in the Research of Probiotic Strains as Alternatives to Antibiotic Growth Promoters in Poultry.
Joan Tarradas, Núria Tous, Enric Esteve-Garcia, And Joaquim Brufau.
Microorganisms, 2020 Jan 25; 8(2). PMID: 31973199    Free PMC article.
Review.
Transcription factor p73 regulates Th1 differentiation.
Min Ren, Majid Kazemian, +9 authors, Warren J Leonard.
Nat Commun, 2020 Mar 21; 11(1). PMID: 32193462    Free PMC article.
The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria.
Graham A D Blyth, Liam Connors, Cristina Fodor, Eduardo R Cobo.
Front Immunol, 2020 Jun 09; 11. PMID: 32508838    Free PMC article.
Review.
Extracellular Vesicles Derived From Trichinella spiralis Muscle Larvae Ameliorate TNBS-Induced Colitis in Mice.
Yong Yang, Lei Liu, +7 authors, Xue Bai.
Front Immunol, 2020 Jul 01; 11. PMID: 32595641    Free PMC article.
Prescription Opioids induce Gut Dysbiosis and Exacerbate Colitis in a Murine Model of Inflammatory Bowel Disease.
Umakant Sharma, Rohini Khatri Olson, +9 authors, Sabita Roy.
J Crohns Colitis, 2019 Nov 28; 14(6). PMID: 31773170    Free PMC article.
Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy.
Kamila Bendickova, Jan Fric.
J Leukoc Biol, 2020 Jun 02; 108(1). PMID: 32480431    Free PMC article.
Review.
Inhibition of LSD1 phosphorylation alleviates colitis symptoms induced by dextran sulfate sodium.
Chaeyoon Oh, Jiyeong Jeong, +2 authors, Keun Il Kim.
BMB Rep, 2020 Apr 23; 53(7). PMID: 32317082    Free PMC article.
Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish.
Camila J Solis, M Kristina Hamilton, +4 authors, Carmen G Feijoo.
Front Immunol, 2020 Aug 15; 11. PMID: 32793187    Free PMC article.
Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease.
Friederike Cordes, Dirk Foell, +2 authors, Dominik Bettenworth.
World J Gastroenterol, 2020 Aug 22; 26(28). PMID: 32821070    Free PMC article.
Review.
The gut microbiome and neuropsychiatric disorders: implications for attention deficit hyperactivity disorder (ADHD).
Kalai Mathee, Trevor Cickovski, +2 authors, Giri Narasimhan.
J Med Microbiol, 2019 Dec 11; 69(1). PMID: 31821133    Free PMC article.
Review.
Prophylactic Effect of Lactobacillus plantarum YS4 on Oxazolone-Induced Colitis in BALB/c Mice.
Ruokun Yi, Fang Tan, +5 authors, Xin Zhao.
Evid Based Complement Alternat Med, 2020 Aug 28; 2020. PMID: 32849906    Free PMC article.
Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis.
Elliot Yi-Hsin Lin, Hsuan-Ju Lai, +6 authors, Hao-Sen Chiang.
Biomedicines, 2020 Aug 09; 8(8). PMID: 32764411    Free PMC article.
Modulation of NLRP3 Inflammasome Attenuated Inflammatory Response Associated to Diarrhea-Predominant Irritable Bowel Syndrome.
Sarah Adriana Scuderi, Giovanna Casili, +4 authors, Michela Campolo.
Biomedicines, 2020 Nov 26; 8(11). PMID: 33233503    Free PMC article.
Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis.
Carsten Alt, Jennifer S Lam, +4 authors, Annalisa D'Andrea.
Eur J Pharmacol, 2012 Mar 28; 683(1-3). PMID: 22449384    Free PMC article.
Top-100 highest-cited original articles in inflammatory bowel disease: A bibliometric analysis.
Xinrong Chen, Kun Yang, Yujie Xu, Ka Li.
Medicine (Baltimore), 2019 May 18; 98(20). PMID: 31096525    Free PMC article.
Development of a human primary gut-on-a-chip to model inflammatory processes.
Claudia Beaurivage, Auste Kanapeckaite, +3 authors, Richard A J Janssen.
Sci Rep, 2020 Dec 10; 10(1). PMID: 33293676    Free PMC article.
Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation.
Karla C Fischer, Carmel P Daunt, +3 authors, Anissa M Jabbour.
Cell Death Dis, 2021 Jan 09; 12(1). PMID: 33414459    Free PMC article.
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation.
Jie Zhou, Shuo Huang, +8 authors, Bo Zhu.
Nat Commun, 2019 Jun 05; 10(1). PMID: 31160593    Free PMC article.
Intake of Lactobacillus delbrueckii (pExu:hsp65) Prevents the Inflammation and the Disorganization of the Intestinal Mucosa in a Mouse Model of Mucositis.
Fernanda Alvarenga Lima Barroso, Luís Cláudio Lima de Jesus, +8 authors, Mariana Martins Drumond.
Microorganisms, 2021 Jan 21; 9(1). PMID: 33466324    Free PMC article.
Intestinal Stem Cells and Immune Cell Relationships: Potential Therapeutic Targets for Inflammatory Bowel Diseases.
Qihang Hou, Jingxi Huang, +2 authors, Bingkun Zhang.
Front Immunol, 2021 Feb 16; 11. PMID: 33584726    Free PMC article.
Review.
Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified.
Hiroaki Okuno, Haruei Ogino, +11 authors, Yoshihiro Ogawa.
BMC Gastroenterol, 2021 Feb 18; 21(1). PMID: 33593285    Free PMC article.
Control and dysregulation of redox signalling in the gastrointestinal tract.
Eric L Campbell, Sean P Colgan.
Nat Rev Gastroenterol Hepatol, 2018 Nov 18; 16(2). PMID: 30443019    Free PMC article.
Review.
The Kobe University Human Intestinal Microbiota Model for gut intervention studies.
Namiko Hoshi, Jun Inoue, Daisuke Sasaki, Kengo Sasaki.
Appl Microbiol Biotechnol, 2021 Mar 16; 105(7). PMID: 33718974
Review.
Exposure to p40 in Early Life Prevents Intestinal Inflammation in Adulthood Through Inducing a Long-Lasting Epigenetic Imprint on TGFβ.
Yilin Deng, Oliver G McDonald, +5 authors, Fang Yan.
Cell Mol Gastroenterol Hepatol, 2021 Jan 23; 11(5). PMID: 33482393    Free PMC article.
Bruton's tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response.
Di Guan, Zixi Wang, +2 authors, Kong-Peng Lam.
Cell Death Dis, 2021 May 02; 12(5). PMID: 33931590    Free PMC article.
Phytochemicals Targeting JAK-STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models.
Sun Young Moon, Kwang Dong Kim, +2 authors, Cheol Hwangbo.
Molecules, 2021 Jun 03; 26(9). PMID: 34068714    Free PMC article.
Review.
STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
Ya-Li Yu, Meng Chen, +7 authors, Mei Ye.
Clin Epigenetics, 2021 Jun 12; 13(1). PMID: 34112215    Free PMC article.
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis.
Larissa Hering, Egle Katkeviciute, +10 authors, Marianne R Spalinger.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201918    Free PMC article.
Cytokines: From Clinical Significance to Quantification.
Chao Liu, Dewei Chu, +3 authors, Guozhen Liu.
Adv Sci (Weinh), 2021 Jun 12; 8(15). PMID: 34114369    Free PMC article.
Review.
Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens.
Emanuel Gumina, Jeffrey W Hall, +4 authors, Sherry Layton.
Poult Sci, 2021 Aug 02; 100(9). PMID: 34333387    Free PMC article.
Short-Chain Naphthoquinone Protects Against Both Acute and Spontaneous Chronic Murine Colitis by Alleviating Inflammatory Responses.
Sonia Shastri, Tanvi Shinde, +3 authors, Rajaraman Eri.
Front Pharmacol, 2021 Sep 10; 12. PMID: 34497514    Free PMC article.
Naringin Exerts Therapeutic Effects on Mice Colitis: A Study Based on Transcriptomics Combined With Functional Experiments.
Jianyi Dong, Yuanyuan Chen, +8 authors, Dapeng Chen.
Front Pharmacol, 2021 Sep 11; 12. PMID: 34504431    Free PMC article.
Tannic acid acts as an agonist of the dopamine D2L receptor, regulates immune responses, and ameliorates experimentally induced colitis in mice.
Masaaki Kawano, Kikue Saika, +2 authors, Sho Matsushita.
Brain Behav Immun Health, 2020 Apr 30; 5. PMID: 34589853    Free PMC article.
Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.
Amy M Tsou, Jeremy A Goettel, +18 authors, Scott B Snapper.
Microbiome, 2021 Nov 05; 9(1). PMID: 34732258    Free PMC article.