Review
. 2002 May; 12(2):89-96.
doi: 10.1006/scbi.2001.0416.

Critical determinants of metastasis

Isaiah J Fidler 1 
Affiliations
  • PMID: 12027580
  •     126 citations

Abstract

The major cause of death from cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second, the process of metastasis selects for a small subpopulation of cells that preexist within a parental neoplasm. Third, and perhaps the greatest obstacle for therapy, is that the outcome of metastasis depends on multiple interactions ('cross-talk') of metastatic cells with homeostatic mechanisms which the tumor cells usurp. Most recent data demonstrate that the organ microenvironment can influence the growth, invasion, and response of metastases to chemotherapy. Therapy of metastasis should therefore be targeted against both the metastatic tumor cells and the homeostatic factors that promote metastasis.

Experimental animal models of pancreatic carcinogenesis and metastasis.
Daoyan Wei, Henry Q Xiong, James L Abbruzzese, Keping Xie.
Int J Gastrointest Cancer, 2003 Aug 12; 33(1). PMID: 12909737
Review.
An experimental platform for studying growth and invasiveness of tumor cells within teratomas derived from human embryonic stem cells.
Maty Tzukerman, Tzur Rosenberg, +3 authors, Karl Skorecki.
Proc Natl Acad Sci U S A, 2003 Oct 24; 100(23). PMID: 14573705    Free PMC article.
ING-1(heMAb), a monoclonal antibody to epithelial cell adhesion molecule, inhibits tumor metastases in a murine cancer model.
Harry H Ruan, Kristen R Scott, Eddie Bautista, W Steve Ammons.
Neoplasia, 2004 Feb 18; 5(6). PMID: 14965442    Free PMC article.
Host genetics and tumour metastasis.
K W Hunter.
Br J Cancer, 2004 Feb 19; 90(4). PMID: 14970848    Free PMC article.
Review.
Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics.
Yan Li, Bo Tian, +5 authors, Zhao-You Tang.
J Cancer Res Clin Oncol, 2004 May 18; 130(8). PMID: 15146329
Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder.
Christine L Chaffer, Bonnie Dopheide, +4 authors, Elizabeth D Williams.
Clin Exp Metastasis, 2005 Aug 09; 22(2). PMID: 16086232
Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine.
Hiroko Yoshino, Mitsuru Futakuchi, +5 authors, Tomoyuki Shirai.
Clin Exp Metastasis, 2005 Nov 12; 22(5). PMID: 16283487
Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy.
Kelly E Fathers, Courtney M Stone, +4 authors, Brenda L Coomber.
Am J Pathol, 2005 Nov 30; 167(6). PMID: 16314485    Free PMC article.
Stress hormone-mediated invasion of ovarian cancer cells.
Anil K Sood, Robert Bhatty, +7 authors, Steven W Cole.
Clin Cancer Res, 2006 Jan 24; 12(2). PMID: 16428474    Free PMC article.
Highly Cited.
L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma.
Jussuf T Kaifi, Ulrich Zinnkann, +7 authors, Jakob R Izbicki.
World J Gastroenterol, 2006 Jan 28; 12(1). PMID: 16440424    Free PMC article.
mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.
Pankaj Gupta, Zao-zhong Su, +8 authors, Paul B Fisher.
Pharmacol Ther, 2006 Feb 09; 111(3). PMID: 16464504    Free PMC article.
Review.
Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance.
Jin-Jing Ke, Qin-Shu Shao, Zhi-Qiang Ling.
World J Gastroenterol, 2006 Jun 15; 12(22). PMID: 16773720    Free PMC article.
Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.
Long Wang, Jin-Shui Zhu, +2 authors, Jin-Lian Chen.
World J Gastroenterol, 2006 Nov 17; 12(43). PMID: 17109515    Free PMC article.
Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice.
Robert W Engelman, Rosalind J Jackson, +3 authors, W Jack Pledger.
Exp Mol Pathol, 2007 Jan 09; 82(3). PMID: 17207793    Free PMC article.
Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Maximilian Bockhorn, Rakesh K Jain, Lance L Munn.
Lancet Oncol, 2007 May 01; 8(5). PMID: 17466902    Free PMC article.
Review.
CXCL5 overexpression is associated with late stage gastric cancer.
Jeong Youp Park, Kyung Hwa Park, +5 authors, Si Young Song.
J Cancer Res Clin Oncol, 2007 May 05; 133(11). PMID: 17479287
High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
Bruno Fuchs, Eric Mahlum, +5 authors, Gobinda Sarkar.
Gene, 2007 Jun 15; 399(2). PMID: 17560052    Free PMC article.
Multifaceted roles of integrins in breast cancer metastasis.
Donald E White, William J Muller.
J Mammary Gland Biol Neoplasia, 2007 Jul 03; 12(2-3). PMID: 17602286
Review.
NrCAM, a neuronal system cell-adhesion molecule, is induced in papillary thyroid carcinomas.
B Górka, J Skubis-Zegadło, +3 authors, B Czarnocka.
Br J Cancer, 2007 Aug 02; 97(4). PMID: 17667921    Free PMC article.
The CXCR4-SDF1alpha axis is a critical mediator of rhabdomyosarcoma metastatic signaling induced by bone marrow stroma.
Brigitte Strahm, Adam D Durbin, Elizabeth Sexsmith, David Malkin.
Clin Exp Metastasis, 2007 Sep 05; 25(1). PMID: 17768666
Organ selectivity in metastasis: regulation by chemokines and their receptors.
Adit Ben-Baruch.
Clin Exp Metastasis, 2007 Sep 25; 25(4). PMID: 17891505
Review.
Mechanisms of oncogenic cooperation in cancer initiation and metastasis.
Laura G Pedraza-Fariña.
Yale J Biol Med, 2007 Oct 18; 79(3-4). PMID: 17940619    Free PMC article.
Review.
Potential therapeutic strategies for lymphatic metastasis.
Bernadette M M Zwaans, Diane R Bielenberg.
Microvasc Res, 2007 Oct 24; 74(2-3). PMID: 17950368    Free PMC article.
Review.
Lack of Thy1 (CD90) expression in neuroblastomas is correlated with impaired survival.
Henning C Fiegel, Jussuf T Kaifi, +8 authors, Dietrich Kluth.
Pediatr Surg Int, 2007 Oct 24; 24(1). PMID: 17952444
Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis.
Zhigang Li, Christian Schem, +2 authors, Ming Zhang.
Clin Exp Metastasis, 2007 Oct 30; 25(4). PMID: 17965942
New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment.
Jonathan P Sleeman, Natascha Cremers.
Clin Exp Metastasis, 2007 Nov 01; 24(8). PMID: 17972145
Review.
A "class action" against the microenvironment: do cancer cells cooperate in metastasis?
François-Clément Bidard, Jean-Yves Pierga, Anne Vincent-Salomon, Marie-France Poupon.
Cancer Metastasis Rev, 2007 Dec 11; 27(1). PMID: 18066649    Free PMC article.
Review.
Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29).
M Gallicchio, A C Rosa, +4 authors, R Fantozzi.
Br J Pharmacol, 2007 Dec 18; 153(5). PMID: 18084318    Free PMC article.
Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors.
Toshio Kuwai, Toru Nakamura, +6 authors, Isaiah J Fidler.
Am J Pathol, 2008 Jan 19; 172(2). PMID: 18202197    Free PMC article.
Cigarette smoking and risk of lung metastasis from esophageal cancer.
Julian A Abrams, Paul C Lee, +2 authors, Alfred I Neugut.
Cancer Epidemiol Biomarkers Prev, 2008 Oct 10; 17(10). PMID: 18843013    Free PMC article.
The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer.
S Al-Saad, K Al-Shibli, +3 authors, L-T Busund.
Br J Cancer, 2008 Oct 16; 99(9). PMID: 18854838    Free PMC article.
Gene profiles between non-invasive and invasive colon cancer using laser microdissection and polypeptide analysis.
Jin-Shui Zhu, Hua Guo, +3 authors, Qiang Zhang.
World J Gastroenterol, 2008 Oct 16; 14(38). PMID: 18855989    Free PMC article.
Midkine is highly expressed in neuroblastoma tissues.
Henning C Fiegel, Jussuf T Kaifi, +9 authors, Holger Till.
Pediatr Surg Int, 2008 Oct 29; 24(12). PMID: 18956201
Assaying Wnt5A-mediated invasion in melanoma cells.
Michael P O'Connell, Amanda D French, Poloko D Leotlela, Ashani T Weeraratna.
Methods Mol Biol, 2008 Dec 23; 468. PMID: 19099260    Free PMC article.
The TGF-beta paradox in human cancer: an update.
Maozhen Tian, William P Schiemann.
Future Oncol, 2009 Mar 17; 5(2). PMID: 19284383    Free PMC article.
Review.
The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice.
Megumi Funakoshi-Tago, Kenji Tago, +5 authors, Tadashi Kasahara.
J Biol Chem, 2009 Mar 18; 284(19). PMID: 19289461    Free PMC article.
Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis.
Jing Wu, Baogang Zhang, +4 authors, Ning Zhang.
Invest New Drugs, 2009 Mar 28; 28(3). PMID: 19326049
Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells.
Jonathan W Song, Stephen P Cavnar, +5 authors, Shuichi Takayama.
PLoS One, 2009 Jun 02; 4(6). PMID: 19484126    Free PMC article.
Highly Cited.
Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27.
Melissa C Garcia, Denise M Ray, +3 authors, John D Roberts.
J Biol Chem, 2009 Jun 10; 284(31). PMID: 19506078    Free PMC article.
Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs.
Emmanuelle Pradelli, Babou Karimdjee-Soilihi, +10 authors, Heidy Schmid-Antomarchi.
Int J Cancer, 2009 Jun 23; 125(11). PMID: 19544560    Free PMC article.
Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression.
Wen Yue, Quanhong Sun, +4 authors, Lin Zhang.
Cancer Res, 2009 Jul 09; 69(15). PMID: 19584278    Free PMC article.
Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness.
L-B Weiswald, S Richon, +13 authors, V Dangles-Marie.
Br J Cancer, 2009 Jul 16; 101(3). PMID: 19603013    Free PMC article.
Changes in the endocannabinoid system may give insight into new and effective treatments for cancer.
Gianfranco Alpini, Sharon Demorrow.
Vitam Horm, 2009 Aug 04; 81. PMID: 19647123    Free PMC article.
Review.
Defining the role of laminin-332 in carcinoma.
Cherise M Guess, Vito Quaranta.
Matrix Biol, 2009 Aug 19; 28(8). PMID: 19686849    Free PMC article.
Review.
STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.
Megumi Funakoshi-Tago, Kenji Tago, +2 authors, Tadashi Kasahara.
J Biol Chem, 2009 Dec 24; 285(8). PMID: 20028972    Free PMC article.
Frontiers in cancer nanomedicine: directing mass transport through biological barriers.
Mauro Ferrari.
Trends Biotechnol, 2010 Jan 19; 28(4). PMID: 20079548    Free PMC article.
Review.
Osteopontin: an effector and an effect of tumor metastasis.
L A Shevde, S Das, D W Clark, R S Samant.
Curr Mol Med, 2010 Mar 09; 10(1). PMID: 20205680    Free PMC article.
Review.
The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms.
Mike R Russell, Qingxin Liu, +2 authors, Alessandro Fatatis.
Cancer Res, 2010 May 06; 70(10). PMID: 20442296    Free PMC article.
AACR centennial series: the biology of cancer metastasis: historical perspective.
James E Talmadge, Isaiah J Fidler.
Cancer Res, 2010 Jul 09; 70(14). PMID: 20610625    Free PMC article.
Highly Cited. Review.
Transforming growth factor-β and the hallmarks of cancer.
Maozhen Tian, Jason R Neil, William P Schiemann.
Cell Signal, 2010 Oct 14; 23(6). PMID: 20940046    Free PMC article.
Highly Cited. Review.
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Shinichi Yachida, Siân Jones, +11 authors, Christine A Iacobuzio-Donahue.
Nature, 2010 Oct 29; 467(7319). PMID: 20981102    Free PMC article.
Highly Cited.
MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer.
Xiaohua Li, Ying Zhang, +8 authors, Daiming Fan.
J Cell Mol Med, 2010 Oct 30; 15(9). PMID: 21029372    Free PMC article.
Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment.
Russell R Braeuer, Maya Zigler, +2 authors, Menashe Bar-Eli.
Semin Cancer Biol, 2010 Dec 15; 21(2). PMID: 21147226    Free PMC article.
Review.
Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.
D J Mole, C O'Neill, +6 authors, F C Campbell.
Br J Cancer, 2011 Feb 24; 104(6). PMID: 21343932    Free PMC article.
RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells.
T Yan, G Tang, +4 authors, W Guo.
Cancer Gene Ther, 2011 Mar 26; 18(6). PMID: 21436869    Free PMC article.
Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2.
Ran Zhao, Tian-Zhen Wang, +6 authors, Xiao-Ming Jin.
World J Gastroenterol, 2011 Mar 31; 17(9). PMID: 21448419    Free PMC article.
Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin.
D F Alonso, G V Ripoll, +2 authors, D E Gomez.
Curr Pharm Biotechnol, 2011 Apr 08; 12(11). PMID: 21470136    Free PMC article.
Review.
Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes.
Do Hee Lee, Youra Lee, +5 authors, Byoung Chul Park.
Mol Cells, 2011 May 03; 31(6). PMID: 21533548    Free PMC article.
CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis.
Laura M Hix, Yihui H Shi, +3 authors, Ming Zhang.
PLoS One, 2011 Jun 23; 6(6). PMID: 21695190    Free PMC article.
Roles of bone marrow cells in skeletal metastases: no longer bystanders.
Serk In Park, Fabiana N Soki, Laurie K McCauley.
Cancer Microenviron, 2011 Aug 03; 4(3). PMID: 21809058    Free PMC article.
Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia.
Gordon R Macpherson, Charlotte A Hanson, +3 authors, Sandra K Ruscetti.
Leuk Res, 2011 Sep 20; 36(3). PMID: 21924771    Free PMC article.
MicroRNAs associated with metastatic prostate cancer.
Akira Watahiki, Yuwei Wang, +5 authors, Yuzhuo Wang.
PLoS One, 2011 Oct 08; 6(9). PMID: 21980368    Free PMC article.
Highly Cited.
Soiling the seed: microenvironment and epithelial mesenchymal plasticity.
Izhak Haviv, Erik W Thompson.
Cancer Microenviron, 2012 Apr 25; 5(1). PMID: 22528875    Free PMC article.
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links.
Christina Scheel, Robert A Weinberg.
Semin Cancer Biol, 2012 May 05; 22(5-6). PMID: 22554795    Free PMC article.
Highly Cited. Review.
The role of lymph node metastasis in the systemic dissemination of breast cancer.
S David Nathanson, David Kwon, +2 authors, Dhananjay Chitale.
Indian J Surg Oncol, 2010 Dec 01; 1(4). PMID: 22695980    Free PMC article.
Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies.
Lindsay J Talbot, Syamal D Bhattacharya, Paul C Kuo.
Int J Biochem Mol Biol, 2012 Jul 10; 3(2). PMID: 22773954    Free PMC article.
Highly Cited.
AB0 blood group and prognosis in patients with pancreatic cancer.
Nuh N Rahbari, Ulrich Bork, +5 authors, Jürgen Weitz.
BMC Cancer, 2012 Jul 31; 12. PMID: 22838843    Free PMC article.
Vascular development in mouse lung metastases.
Howard W Salmon, Ananya Guha, Amyn M Rojiani, Dietmar W Siemann.
Am J Cancer Res, 2012 Sep 08; 2(5). PMID: 22957309    Free PMC article.
Upregulation of C-X-C chemokine receptor type 1 expression is associated with late-stage gastric adenocarcinoma.
Jun Pu Wang, Wan Ming Hu, +9 authors, Ji Fang Wen.
Exp Ther Med, 2012 Oct 13; 4(1). PMID: 23060922    Free PMC article.
Expression of intercellular adhesion molecule-1 and e-selectin in gastric cancer and their clinical significance.
Woo-Chul Jung, You-Jin Jang, +5 authors, Chong-Suk Kim.
J Gastric Cancer, 2012 Oct 25; 12(3). PMID: 23094225    Free PMC article.
Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer.
Y Okugawa, K Tanaka, +9 authors, M Kusunoki.
Br J Cancer, 2012 Nov 24; 108(1). PMID: 23175149    Free PMC article.
Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis.
Yu-Chen Lee, Jung-Kang Jin, +11 authors, Sue-Hwa Lin.
Mol Cancer Res, 2013 Jan 23; 11(4). PMID: 23339185    Free PMC article.
CCL19/CCR7 upregulates heparanase via specificity protein-1 (Sp1) to promote invasion of cell in lung cancer.
Qingfu Zhang, Limei Sun, +4 authors, Xueshan Qiu.
Tumour Biol, 2013 May 08; 34(5). PMID: 23649655
Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer.
Mingchen Zhu, Yijun Xu, +3 authors, Feng Yan.
Pathol Oncol Res, 2013 Jun 06; 19(4). PMID: 23737034
Induction of an EMT-like transformation and MET in vitro.
Songming Ding, Wu Zhang, +9 authors, Shusen Zheng.
J Transl Med, 2013 Jul 09; 11. PMID: 23829659    Free PMC article.
Single-cell sequencing-based technologies will revolutionize whole-organism science.
Ehud Shapiro, Tamir Biezuner, Sten Linnarsson.
Nat Rev Genet, 2013 Jul 31; 14(9). PMID: 23897237
Highly Cited. Review.
[Invasion patterns and metastasis of urothelial carcinoma. A challenge for translational research].
C Bolenz, T Martini, M S Michel.
Urologe A, 2013 Aug 28; 52(9). PMID: 23979445
Review.
Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-PymT mammary cancer cells in vivo.
J L Werbeck, N K Thudi, +4 authors, T J Rosol.
Vet Pathol, 2013 Oct 05; 51(4). PMID: 24091811    Free PMC article.
GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Wenliang Li, Nanping Ai, +12 authors, Randolph S Watnick.
Proc Natl Acad Sci U S A, 2014 Jan 18; 111(4). PMID: 24434559    Free PMC article.
Comparison of site-specific gene expression levels in primary tumors and synchronous lymph node metastases in advanced gastric cancer.
Akira Naruke, Mizutomo Azuma, +7 authors, Wasaburo Koizumi.
Gastric Cancer, 2014 Mar 22; 18(2). PMID: 24651981
Longitudinal imaging of cancer cell metastases in two preclinical models: a correlation of noninvasive imaging to histopathology.
Pavan P Adiseshaiah, Nimit L Patel, +3 authors, Scott E McNeil.
Int J Mol Imaging, 2014 Apr 12; 2014. PMID: 24724022    Free PMC article.
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer.
Michael W Hance, Krystal D Nolan, Jennifer S Isaacs.
Cancers (Basel), 2014 May 09; 6(2). PMID: 24805867    Free PMC article.
Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma.
Lee Chun Park, Ji Yun Jeong, +4 authors, Yeon Hee Park.
Cancer Res Treat, 2014 May 23; 46(2). PMID: 24851113    Free PMC article.
Redox modulation of FAK controls melanoma survival--role of NOX4.
Cristiane Ribeiro-Pereira, João Alfredo Moraes, +3 authors, Christina Barja-Fidalgo.
PLoS One, 2014 Jun 10; 9(6). PMID: 24911159    Free PMC article.
AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells.
Zhenzhen Zhou, Huan Deng, +7 authors, De'an Tian.
PLoS One, 2014 Jun 19; 9(6). PMID: 24941119    Free PMC article.
In vitro cell migration and invasion assays.
Calvin R Justus, Nancy Leffler, Maria Ruiz-Echevarria, Li V Yang.
J Vis Exp, 2014 Jun 26; (88). PMID: 24962652    Free PMC article.
Highly Cited.
miR-429 inhibits migration and invasion of breast cancer cells in vitro.
Zhi-Bin Ye, Gang Ma, +6 authors, Sheng-Ji Yu.
Int J Oncol, 2014 Nov 19; 46(2). PMID: 25405387    Free PMC article.
The lymph node microenvironment and its role in the progression of metastatic cancer.
Ethel R Pereira, Dennis Jones, Keehoon Jung, Timothy P Padera.
Semin Cell Dev Biol, 2015 Jan 27; 38. PMID: 25620792    Free PMC article.
Review.
Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.
Yoshinaga Okugawa, Yuji Toiyama, +7 authors, Ajay Goel.
Gut, 2015 Oct 18; 66(1). PMID: 26475630    Free PMC article.
The evolution of tumor metastasis during clonal expansion with alterations in metastasis driver genes.
Kimiyo N Yamamoto, Akira Nakamura, Hiroshi Haeno.
Sci Rep, 2015 Oct 31; 5. PMID: 26515895    Free PMC article.
Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.
Sedef Iskit, Andreas Schlicker, Lodewyk Wessels, Daniel S Peeper.
Oncotarget, 2015 Dec 10; 6(41). PMID: 26646695    Free PMC article.
Histological evaluation for chemotherapeutic responses of metastatic lymph nodes in gastric cancer.
Osamu Kinoshita, Daisuke Ichikawa, +5 authors, Eigo Otsuji.
World J Gastroenterol, 2016 Jan 06; 21(48). PMID: 26730161    Free PMC article.
Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
Farhoud Faraji, Ying Hu, +4 authors, Kent W Hunter.
PLoS Genet, 2016 Jan 26; 12(1). PMID: 26807845    Free PMC article.
Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression.
Francesco Crea, Luca Quagliata, +17 authors, Cheryl D Helgason.
Mol Oncol, 2016 Jan 27; 10(5). PMID: 26809501    Free PMC article.
Establishment and characterization of a metastasis model of human gastric cancer in nude mice.
Kesheng Li, Huifen Du, +4 authors, Chunya Wang.
BMC Cancer, 2016 Feb 06; 16. PMID: 26847082    Free PMC article.
Detecting Tumor Metastases: The Road to Therapy Starts Here.
M E Menezes, S K Das, +5 authors, P B Fisher.
Adv Cancer Res, 2016 Sep 11; 132. PMID: 27613128    Free PMC article.
Review.
Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway.
E Leung, A Xue, +5 authors, J Condeelis.
Oncogene, 2016 Nov 29; 36(19). PMID: 27893712    Free PMC article.
Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells.
Sheeja Aravindan, Satishkumar Ramraj, +4 authors, Natarajan Aravindan.
Oncotarget, 2016 Dec 16; 8(4). PMID: 27974694    Free PMC article.
High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma.
Peng Ren, Chuangui Chen, +2 authors, Zhentao Yu.
Onco Targets Ther, 2017 Feb 24; 10. PMID: 28228658    Free PMC article.
HGF/c-MET Axis in Tumor Microenvironment and Metastasis Formation.
Anna Spina, Valeria De Pasquale, +4 authors, Luigi Michele Pavone.
Biomedicines, 2015 Jan 22; 3(1). PMID: 28536400    Free PMC article.
Review.
Investigation of Metastasis-Related Genes: A Rat Model Mimicking Liver Metastasis of Colorectal Carcinoma.
Hassan Adwan, Rania Georges, Asim Pervaiz, Martin R Berger.
Front Oncol, 2017 Aug 05; 7. PMID: 28770169    Free PMC article.
Review.
Expression of family with sequence similarity 172 member A and nucleotide-binding protein 1 is associated with the poor prognosis of colorectal carcinoma.
Wenjun Liu, Shuang Wang, +3 authors, Hao Liu.
Oncol Lett, 2017 Sep 21; 14(3). PMID: 28927116    Free PMC article.
Redox status in the sentinel lymph node of women with breast cancer.
María Jesús Ramírez-Expósito, Nieves Urbano-Polo, +4 authors, José Manuel Martínez-Martos.
Ups J Med Sci, 2017 Dec 22; 122(4). PMID: 29264992    Free PMC article.
The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells.
Muhammad Mushtaq, Lasse Jensen, +4 authors, Elena Kashuba.
Sci Rep, 2018 Feb 06; 8(1). PMID: 29396484    Free PMC article.
Development of pipette tip gap closure migration assay (s-ARU method) for studying semi-adherent cell lines.
Swapnil Ganesh Sanmukh, Sérgio Luis Felisbino.
Cytotechnology, 2018 Aug 03; 70(6). PMID: 30069611    Free PMC article.
Caffeic Acid Versus Caffeic Acid Phenethyl Ester in the Treatment of Breast Cancer MCF-7 Cells: Migration Rate Inhibition.
Agata Kabała-Dzik, Anna Rzepecka-Stojko, +3 authors, Jerzy Stojko.
Integr Cancer Ther, 2018 Sep 25; 17(4). PMID: 30246565    Free PMC article.
The bone microenvironment promotes tumor growth and tissue perfusion compared with striated muscle in a preclinical model of prostate cancer in vivo.
Haider Mussawy, Lennart Viezens, +5 authors, Christian Schaefer.
BMC Cancer, 2018 Oct 18; 18(1). PMID: 30326868    Free PMC article.
Risk Assessment of kINPen Plasma Treatment of Four Human Pancreatic Cancer Cell Lines with Respect to Metastasis.
Sander Bekeschus, Eric Freund, +10 authors, André Käding.
Cancers (Basel), 2019 Aug 28; 11(9). PMID: 31450811    Free PMC article.
Novel Quinoline-based Ir(III) Complexes Exhibit High Antitumor Activity in Vitro and in Vivo.
Yan Yang, Yi-Dong Bin, +3 authors, Hua-Xin Zhang.
ACS Med Chem Lett, 2019 Dec 21; 10(12). PMID: 31857836    Free PMC article.
Increased Cell Detachment Ratio of Mesenchymal-Type Lung Cancer Cells on pH-Responsive Chitosan through the β3 Integrin.
Chia-Hsiang Yen, Tai-Horng Young, +2 authors, Tsung-Wei Huang.
Mar Drugs, 2019 Nov 28; 17(12). PMID: 31771240    Free PMC article.
Protein kinase TTK promotes proliferation and migration and mediates epithelial-mesenchymal transition in human bladder cancer cells.
Feiran Chen, Peikang Wu, +3 authors, Changli Wu.
Int J Clin Exp Pathol, 2018 Oct 01; 11(10). PMID: 31949560    Free PMC article.
Low Molecular Weight Heparin-Coated and Dendrimer-Based Core-Shell Nanoplatform with Enhanced Immune Activation and Multiple Anti-Metastatic Effects for Melanoma Treatment.
Chunyu Xia, Sheng Yin, +8 authors, Qin He.
Theranostics, 2019 Feb 28; 9(2). PMID: 30809278    Free PMC article.
Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors.
Sayka Barry, Eivind Carlsen, +13 authors, Márta Korbonits.
Oncogene, 2019 Mar 15; 38(27). PMID: 30867568    Free PMC article.
Clinicopathological Evaluation of the Potential Anatomic Pathways of Systemic Metastasis from Primary Breast Cancer Suggests an Orderly Spread Through the Regional Lymph Nodes.
S David Nathanson, Shravan Leonard-Murali, +2 authors, Patricia Baker.
Ann Surg Oncol, 2020 Jul 29; 27(12). PMID: 32720039    Free PMC article.
Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype.
Mayassa J Bou-Dargham, Qing-Xiang Amy Sang.
PLoS One, 2020 Aug 09; 15(8). PMID: 32764784    Free PMC article.
Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes.
Khamael M K Al-Taee, Michael Zepp, +2 authors, Hassan Adwan.
Genes Cancer, 2019 Jan 04; 9(5-6). PMID: 30603057    Free PMC article.
Lower Expression of Gelsolin in Colon Cancer and Its Diagnostic Value in Colon Cancer Patients.
Zhuoyu Chen, Kaifei Li, +5 authors, Yurong Qiu.
J Cancer, 2019 Mar 12; 10(5). PMID: 30854138    Free PMC article.
Anti-Tumor Effects of Low Dose Zoledronate on Lung Cancer-Induced Spine Metastasis.
Elie Akoury, Ana Sofia Ramirez Garcia Luna, +4 authors, Derek H Rosenzweig.
J Clin Med, 2019 Aug 17; 8(8). PMID: 31416169    Free PMC article.
The expression level of fibulin-2 in the circulating RNA (ctRNA) of epithelial tumor cells of peripheral blood and tumor tissue of patients with metastatic lung cancer.
Mukaddes Avsar, Makbule Tambas, +8 authors, Hulya Yazici.
Mol Biol Rep, 2019 May 10; 46(4). PMID: 31069614
Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells.
Liping Li, Songxin Yan, +3 authors, Miaojuan Chen.
BMC Cancer, 2019 Sep 08; 19(1). PMID: 31492158    Free PMC article.
MiRNA-516a promotes bladder cancer metastasis by inhibiting MMP9 protein degradation via the AKT/FOXO3A/SMURF1 axis.
Yuanyuan Chang, Honglei Jin, +15 authors, Haishan Huang.
Clin Transl Med, 2020 Dec 31; 10(8). PMID: 33377649    Free PMC article.
Proprotein Convertase Subtilisin/Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apoptosis by Facilitating MAPK Signaling Pathway Through HSP70 Up-Regulation.
Beili Xu, Shuyu Li, +4 authors, Yu Cai.
Front Oncol, 2021 Jan 26; 10. PMID: 33489919    Free PMC article.
Vascularized Biomaterials to Study Cancer Metastasis.
Katharine R Bittner, Juan M Jiménez, Shelly R Peyton.
Adv Healthc Mater, 2020 Jan 25; 9(8). PMID: 31977160    Free PMC article.
Review.
TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs.
Meicen Zhou, Wenbao Lu, +2 authors, Ailing Li.
Cancer Sci, 2021 Jan 24; 112(3). PMID: 33484209    Free PMC article.
Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma.
Anamika Singh, Ariel Erijman, +4 authors, Julia M Shifman.
J Biol Chem, 2021 Nov 01; 297(6). PMID: 34717958    Free PMC article.
Anticancer Effect of Heparin-Taurocholate Conjugate on Orthotopically Induced Exocrine and Endocrine Pancreatic Cancer.
Hae Hyun Hwang, Hee Jeong Jeong, +4 authors, Dong Yun Lee.
Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34830928    Free PMC article.