Journal Article
. 2002 Jul;359(9324).
doi: 10.1016/s0140-6736(02)09088-8.

Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial

M Baum  A U Budzar  J Cuzick  J Forbes  J H Houghton  J G M Klijn  T Sahmoud  ATAC Trialists' Group  
  • PMID: 12090977
  •     373 citations


Background: In the adjuvant setting, tamoxifen is the established treatment for postmenopausal women with hormone-sensitive breast cancer. However, it is associated with several side-effects including endometrial cancer and thromboembolic disorders. We aimed to compare the safety and efficacy outcomes of tamoxifen with those of anastrozole alone and the combination of anastrozole plus tamoxifen for 5 years.

Methods: Participants were postmenopausal patients with invasive operable breast cancer who had completed primary therapy and were eligible to receive adjuvant hormonal therapy. The primary endpoints were disease-free survival and occurrence of adverse events. Analysis for efficacy was by intention to treat.

Findings: 9366 patients were recruited, of whom 3125 were randomly assigned anastrozole, 3116 tamoxifen, and 3125 combination. Median follow-up was 33.3 months. 7839 (84%) patients were known to be hormone-receptor-positive. Disease-free survival at 3 years was 89.4% on anastrozole and 87.4% on tamoxifen (hazard ratio 0.83 [95% CI 0.71-0.96], p=0.013). Results with the combination were not significantly different from those with tamoxifen alone (87.2%, 1.02 [0.89-1.18], p=0.8). The improvement in disease-free survival with anastrozole was seen in the subgroup of hormone-receptor-positive patients, but not the receptor-negative patients. Incidence of contralateral breast cancer was significantly lower with anastrozole than with tamoxifen (odds ratio 0.42 [0.22-0.79], p=0.007). Anastrozole was significantly better tolerated than tamoxifen with respect to endometrial cancer (p=0.02), vaginal bleeding and discharge (p<0.0001 for both), cerebrovascular events (p=0.0006), venous thromboembolic events (p=0.0006), and hot flushes (p<0.0001). Tamoxifen was significantly better tolerated than anastrozole with respect to musculoskeletal disorders and fractures (p<0.0001 for both).

Interpretation: Anastrozole is an effective and well tolerated endocrine option for the treatment of postmenopausal patients with hormone-sensitive early breast cancer. Longer follow-up is required before a final benefit:risk assessment can be made.

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M Widschwendter, H Lichtenberg-Frate, +9 authors, H Brenner.
Br J Cancer, 2009 Jun 06; 101(1). PMID: 19491898    Free PMC article.
Second primary breast cancer occurrence according to hormone receptor status.
Allison W Kurian, Laura A McClure, +3 authors, Christina A Clarke.
J Natl Cancer Inst, 2009 Jul 11; 101(15). PMID: 19590058    Free PMC article.
Postoperative endocrine therapy for invasive breast cancer.
Leisha A Emens, Nancy E Davidson.
Cancer Treat Res, 2009 Jul 14; 151. PMID: 19593511    Free PMC article.
A randomized placebo-controlled study of tamoxifen after adjuvant chemotherapy in premenopausal women with early breast cancer (National Cancer Institute of Canada--Clinical Trials Group Trial, MA.12).
V H C Bramwell, K I Pritchard, +8 authors, L Shepherd.
Ann Oncol, 2009 Jul 25; 21(2). PMID: 19628570    Free PMC article.
Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer.
Qamar J Khan, Pavan S Reddy, +5 authors, Carol J Fabian.
Breast Cancer Res Treat, 2009 Aug 06; 119(1). PMID: 19655244    Free PMC article.
Tamoxifen: the drug that came in from the cold.
L Hughes-Davies, C Caldas, G C Wishart.
Br J Cancer, 2009 Aug 13; 101(6). PMID: 19672259    Free PMC article.
An updated review on the efficacy of adjuvant endocrine therapies in hormone receptor-positive early breast cancer.
S Verma, S Sehdev, +3 authors, J A Roy.
Curr Oncol, 2009 Aug 13; 16 Suppl 2. PMID: 19672416    Free PMC article.
Safety of adjuvant endocrine therapies in hormone receptor-positive early breast cancer.
S Sehdev, G Martin, +2 authors, S Brisson.
Curr Oncol, 2009 Aug 13; 16 Suppl 2. PMID: 19672417    Free PMC article.
Letrozole: a review of its use in the treatment of postmenopausal women with hormone-responsive early breast cancer.
Gillian M Keating.
Drugs, 2009 Aug 15; 69(12). PMID: 19678717
Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer.
BIG 1-98 Collaborative Group, Henning Mouridsen, +10 authors, Alan S Coates.
N Engl J Med, 2009 Aug 21; 361(8). PMID: 19692688    Free PMC article.
Highly Cited.
Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women.
Monica Milani, Gautam Jha, David A Potter.
Clin Med Ther, 2009 Oct 02; 1. PMID: 19794821    Free PMC article.
Severe prolonged cholestatic hepatitis caused by exemestane.
Ting Bao, John Fetting, +6 authors, Linda Lee.
Breast Cancer Res Treat, 2009 Oct 17; 121(3). PMID: 19834799    Free PMC article.
Feasibility trial of letrozole in combination with bevacizumab in patients with metastatic breast cancer.
Tiffany A Traina, Hope S Rugo, +17 authors, Maura N Dickler.
J Clin Oncol, 2009 Oct 21; 28(4). PMID: 19841327    Free PMC article.
The science and practice of bone health in oncology: managing bone loss and metastasis in patients with solid tumors.
Allan Lipton, Robert Uzzo, +4 authors, Matthew R Smith.
J Natl Compr Canc Netw, 2010 Oct 29; 7 Suppl 7. PMID: 19878635    Free PMC article.
Update on the use of aromatase inhibitors in early-stage breast cancer.
Georgios Kesisis, Andreas Makris, David Miles.
Breast Cancer Res, 2009 Nov 06; 11(5). PMID: 19889200    Free PMC article.
Zoledronic acid for treatment of osteopenia and osteoporosis in women with primary breast cancer undergoing adjuvant aromatase inhibitor therapy.
Stephanie L Hines, Jeff A Sloan, +7 authors, Charles L Loprinzi.
Breast, 2010 Jan 19; 19(2). PMID: 20079640    Free PMC article.
Breast Cancer OncoGuia.
Paula Manchon, Josep M Borràs, +2 authors, Breast Cancer OncoGuia Group.
Clin Transl Oncol, 2010 Feb 17; 12(2). PMID: 20156781
Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR.
Vassiliki Pelekanou, George Notas, +3 authors, Marilena Kampa.
Mol Oncol, 2010 Mar 02; 4(2). PMID: 20189893    Free PMC article.
Docking and 3D-QSAR studies of diverse classes of human aromatase (CYP19) inhibitors.
Partha Pratim Roy, Kunal Roy.
J Mol Model, 2010 Mar 03; 16(10). PMID: 20195667
Management of anastrozole-induced bone loss in breast cancer patients with oral risedronate: results from the ARBI prospective clinical trial.
Christos Markopoulos, Evagelos Tzoracoleftherakis, +13 authors, Helen Gogas.
Breast Cancer Res, 2010 Apr 20; 12(2). PMID: 20398352    Free PMC article.
CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance.
Michaela J Higgins, Vered Stearns.
Curr Oncol Rep, 2010 Apr 29; 12(1). PMID: 20425602
The increasing use of prophylactic mastectomy in the prevention of breast cancer.
Todd M Tuttle, Andrea Abbott, Amanda Arrington, Natasha Rueth.
Curr Oncol Rep, 2010 Apr 29; 12(1). PMID: 20425603
Managing aromatase inhibitors in breast cancer survivors: not just for oncologists.
Julia A Files, Marcia G Ko, Sandhya Pruthi.
Mayo Clin Proc, 2010 Jun 01; 85(6). PMID: 20511486    Free PMC article.
Breast cancer in men in the United States: a population-based study of diagnosis, treatment, and survival.
Linda C Harlan, Jo Anne Zujewski, Marc T Goodman, Jennifer L Stevens.
Cancer, 2010 Jun 22; 116(15). PMID: 20564105    Free PMC article.
The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum.
P E Lønning.
Ann Oncol, 2010 Jul 10; 22(3). PMID: 20616198    Free PMC article.
Breast cancer chemoprevention: progress and controversy.
D Lawrence Wickerham.
Surg Oncol Clin N Am, 2010 Jul 14; 19(3). PMID: 20620921    Free PMC article.
American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer.
Harold J Burstein, Ann Alexis Prestrud, +16 authors, American Society of Clinical Oncology.
J Clin Oncol, 2010 Jul 14; 28(23). PMID: 20625130    Free PMC article.
Highly Cited. Systematic Review.
Molecular therapy of breast cancer: progress and future directions.
Sheng-Xiang Lin, Jiong Chen, +4 authors, Ming Zhou.
Nat Rev Endocrinol, 2010 Jul 21; 6(9). PMID: 20644568
Adjuvant Endocrine Therapy in Premenopausal Patients.
Michael Gnant.
Breast Care (Basel), 2008 Jan 01; 3(5). PMID: 20824025    Free PMC article.
Minimizing early relapse and maximizing treatment outcomes in hormone-sensitive postmenopausal breast cancer: efficacy review of AI trials.
Christos J Markopoulos.
Cancer Metastasis Rev, 2010 Sep 11; 29(4). PMID: 20830503    Free PMC article.
Mechanisms of endocrine resistance in breast cancer.
C Kent Osborne, Rachel Schiff.
Annu Rev Med, 2010 Oct 05; 62. PMID: 20887199    Free PMC article.
Highly Cited. Review.
The impact of systemic therapy following ductal carcinoma in situ.
Jennifer Eng-Wong, Joseph P Costantino, Sandra M Swain.
J Natl Cancer Inst Monogr, 2010 Oct 20; 2010(41). PMID: 20956830    Free PMC article.
Endocrine Treatment - 'Old-Fashioned' Therapy Becoming Redundant in an Era of Molecular Medicine?
Per Eystein Lønning.
Breast Care (Basel), 2008 Jan 01; 3(6). PMID: 21048907    Free PMC article.
High prevalence of low vitamin D and musculoskeletal complaints in women with breast cancer.
Nicola Napoli, Swapna Vattikuti, +7 authors, Reina Armamento-Villareal.
Breast J, 2010 Nov 13; 16(6). PMID: 21070438    Free PMC article.
Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients.
J M Neuner, T W Yen, +2 authors, A B Nattinger.
Osteoporos Int, 2010 Dec 21; 22(11). PMID: 21170643    Free PMC article.
FACE: the barefaced facts of AI potency.
Alain Monnier.
Cancer Manag Res, 2010 Dec 29; 2. PMID: 21188118    Free PMC article.
Fulvestrant: a review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women.
Jamie D Croxtall, Kate McKeage.
Drugs, 2011 Feb 16; 71(3). PMID: 21319872
An "omics" approach to determine the mechanisms of acquired aromatase inhibitor resistance.
Shiuan Chen.
OMICS, 2011 Feb 22; 15(6). PMID: 21332390    Free PMC article.
Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer.
K Ted Thurn, Scott Thomas, Amy Moore, Pamela N Munster.
Future Oncol, 2011 Feb 25; 7(2). PMID: 21345145    Free PMC article.
Advances in the preclinical testing of cancer therapeutic hypotheses.
Giordano Caponigro, William R Sellers.
Nat Rev Drug Discov, 2011 Mar 02; 10(3). PMID: 21358737
Differences between the non-steroidal aromatase inhibitors anastrozole and letrozole--of clinical importance?
J Geisler.
Br J Cancer, 2011 Mar 03; 104(7). PMID: 21364577    Free PMC article.
JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters.
Dong Chen, Scott Reierstad, Feng Fang, Serdar E Bulun.
Mol Endocrinol, 2011 Mar 12; 25(5). PMID: 21393445    Free PMC article.
Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitors.
Angela Brodie, Gauri Sabnis.
Clin Cancer Res, 2011 Mar 19; 17(13). PMID: 21415222    Free PMC article.
Binding features of steroidal and nonsteroidal inhibitors.
Yanyan Hong, Rumana Rashid, Shiuan Chen.
Steroids, 2011 Mar 23; 76(8). PMID: 21420422    Free PMC article.
Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection.
Carmen Criscitiello, Debora Fumagalli, Kamal S Saini, Sherene Loi.
Onco Targets Ther, 2011 May 10; 4. PMID: 21552410    Free PMC article.
Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype--ACOSOG Z1031.
Matthew J Ellis, Vera J Suman, +17 authors, John A Olson.
J Clin Oncol, 2011 May 11; 29(17). PMID: 21555689    Free PMC article.
Highly Cited.
Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.
Xin Pan, Tao Zhou, +19 authors, Xue-Min Zhang.
Nat Med, 2011 May 17; 17(6). PMID: 21572428
Paracrine and endocrine effects of adipose tissue on cancer development and progression.
Jiyoung Park, David M Euhus, Philipp E Scherer.
Endocr Rev, 2011 Jun 07; 32(4). PMID: 21642230    Free PMC article.
Highly Cited. Review.
Clinical epidemiology and pharmacology of CYP2D6 inhibition related to breast cancer outcomes.
Deirdre P Cronin-Fenton, Timothy L Lash.
Expert Rev Clin Pharmacol, 2011 Jun 29; 4(3). PMID: 21709817    Free PMC article.
Breast cancer (non-metastatic).
Justin Stebbing, Geoff Delaney, Alastair Thompson.
BMJ Clin Evid, 2011 Jul 02; 2011. PMID: 21718560    Free PMC article.
Systematic Review.
Changes in breast density and circulating estrogens in postmenopausal women receiving adjuvant anastrozole.
Tatiana M Prowell, Amanda L Blackford, +16 authors, Vered Stearns.
Cancer Prev Res (Phila), 2011 Sep 03; 4(12). PMID: 21885816    Free PMC article.
Pharmacoeconomic considerations in the treatment of breast cancer.
Athanasios Pallis, Vasiliki Tsiantou, Efi Simou, Nikos Maniadakis.
Clinicoecon Outcomes Res, 2010 Jan 01; 2. PMID: 21935314    Free PMC article.
Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group.
Mitch Dowsett, Torsten O Nielsen, +19 authors, International Ki-67 in Breast Cancer Working Group.
J Natl Cancer Inst, 2011 Oct 01; 103(22). PMID: 21960707    Free PMC article.
Highly Cited.
Early operable breast cancer in elderly women treated with an aromatase inhibitor letrozole as sole therapy.
A Balakrishnan, D Ravichandran.
Br J Cancer, 2011 Nov 10; 105(12). PMID: 22068814    Free PMC article.
The CIRAS study: a case control study to define the clinical, immunologic, and radiographic features of aromatase inhibitor-induced musculoskeletal symptoms.
Victoria K Shanmugam, James McCloskey, +2 authors, Jennifer Eng-Wong.
Breast Cancer Res Treat, 2011 Nov 15; 131(2). PMID: 22076476    Free PMC article.
Putting the cardiovascular safety of aromatase inhibitors in patients with early breast cancer into perspective: a systematic review of the literature.
Muhammad Younus, Michelle Kissner, Lester Reich, Nicola Wallis.
Drug Saf, 2011 Nov 15; 34(12). PMID: 22077502
Systematic Review.
Preventive effect of risedronate on bone loss and frailty fractures in elderly women treated with anastrozole for early breast cancer.
Giuseppe Sergi, Giulia Pintore, +8 authors, Alessandra Coin.
J Bone Miner Metab, 2011 Dec 14; 30(4). PMID: 22160398
Aromatase, breast cancer and obesity: a complex interaction.
Serdar E Bulun, Dong Chen, +2 authors, Hong Zhao.
Trends Endocrinol Metab, 2011 Dec 16; 23(2). PMID: 22169755    Free PMC article.
Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole.
Lauren Nicole Bell, Anne Thi Phuong Nguyen, +8 authors, Consortium on Breast Cancer Pharmacogenomics (COBRA).
J Clin Pharmacol, 2011 Dec 17; 52(12). PMID: 22174434    Free PMC article.
Human steroid biosynthesis for the oncologist.
Mary Louise Auchus, Richard J Auchus.
J Investig Med, 2012 Jan 10; 60(2). PMID: 22222232    Free PMC article.
The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance.
Cynthie Wong, Shiuan Chen.
J Steroid Biochem Mol Biol, 2012 Jan 24; 131(3-5). PMID: 22265958    Free PMC article.
Role of traditional and new biomarkers in breast carcinogenesis.
D Macis, M Cazzaniga, A De Censi, B Bonanni.
Ecancermedicalscience, 2009 Jan 01; 3. PMID: 22276018    Free PMC article.
Understanding the mechanisms of aromatase inhibitor resistance.
William R Miller, Alexey A Larionov.
Breast Cancer Res, 2012 Jan 27; 14(1). PMID: 22277572    Free PMC article.
Adherence to adjuvant hormonal therapy and its relationship to breast cancer recurrence and survival among low-income women.
Kathryn E Weaver, Fabian Camacho, +2 authors, Gretchen Kimmick.
Am J Clin Oncol, 2012 Feb 09; 36(2). PMID: 22314001    Free PMC article.
Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Susan R Kahn, Wendy Lim, +9 authors, M Hassan Murad.
Chest, 2012 Feb 15; 141(2 Suppl). PMID: 22315261    Free PMC article.
Highly Cited.
Endocrine therapy use among elderly hormone receptor-positive breast cancer patients enrolled in Medicare Part D.
Gerald F Riley, Joan L Warren, Linda C Harlan, Steven A Blackwell.
Medicare Medicaid Res Rev, 2012 Feb 22; 1(4). PMID: 22340780    Free PMC article.
Weight gain increases human aromatase expression in mammary gland.
Dong Chen, Hong Zhao, +3 authors, Serdar E Bulun.
Mol Cell Endocrinol, 2012 Feb 22; 355(1). PMID: 22342815    Free PMC article.
Use of neoadjuvant data to design adjuvant endocrine therapy trials for breast cancer.
Rodrigo Goncalves, Cynthia Ma, +2 authors, Matthew James Ellis.
Nat Rev Clin Oncol, 2012 Mar 01; 9(4). PMID: 22371132    Free PMC article.
CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients.
James M Rae, Suzy Drury, +8 authors, ATAC trialists.
J Natl Cancer Inst, 2012 Mar 08; 104(6). PMID: 22395643    Free PMC article.
Highly Cited.
Hormonal therapy in breast cancer: a model disease for the personalization of cancer care.
Shannon Puhalla, Saveri Bhattacharya, Nancy E Davidson.
Mol Oncol, 2012 Mar 13; 6(2). PMID: 22406404    Free PMC article.
Hormonal therapy for recurrent low-grade serous carcinoma of the ovary or peritoneum.
David M Gershenson, Charlotte C Sun, +5 authors, Michael Deavers.
Gynecol Oncol, 2012 Mar 13; 125(3). PMID: 22406638    Free PMC article.
Construction of a database for the evaluation and the clinical management of patients with breast cancer treated with antiestrogens and/or aromatase inhibitors.
Francesca Giusti, Silva Ottanelli, +3 authors, Alberto Falchetti.
Clin Cases Miner Bone Metab, 2011 Jan 01; 8(1). PMID: 22461802    Free PMC article.
Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study.
Katja Lundgren, Matthew Brown, +7 authors, TransATAC investigators.
Breast Cancer Res, 2012 Apr 06; 14(2). PMID: 22475046    Free PMC article.
Changes in bone biomarker concentrations and musculoskeletal symptoms among breast cancer patients initiating aromatase inhibitor therapy and women without a history of cancer.
Lisa Gallicchio, Ryan MacDonald, +3 authors, Kathy J Helzlsouer.
J Bone Miner Res, 2012 Apr 18; 27(9). PMID: 22508239    Free PMC article.
Non-initiation of adjuvant hormonal therapy in women with hormone receptor-positive breast cancer: The Breast Cancer Quality of Care Study (BQUAL).
Alfred I Neugut, Grace Clarke Hillyer, +10 authors, Dawn L Hershman.
Breast Cancer Res Treat, 2012 Apr 25; 134(1). PMID: 22527111    Free PMC article.
MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
George C Bobustuc, Joshua S Smith, +10 authors, Santhi D Konduri.
Mol Med, 2012 May 03; 18. PMID: 22549111    Free PMC article.
Bilateral de quervain syndrome after aromatase inhibitor administration: a case report and review of the literature.
Konstantinos Papadimitriou, Panteleimon Kountourakis, +3 authors, Alexandros Ardavanis.
Case Rep Med, 2012 May 09; 2012. PMID: 22567020    Free PMC article.
Recurrent Male Breast Cancer Accompanied by Carcinomatous Pleuritis That Responded to Combination Therapy with High-Dose Toremifene and Docetaxel.
Hiroyuki Tsujimoto, Youichi Takemoto, Akeo Hagiwara.
Breast Care (Basel), 2010 Mar 01; 5(1). PMID: 22619639    Free PMC article.
Global microRNA expression profiling of high-risk ER+ breast cancers from patients receiving adjuvant tamoxifen mono-therapy: a DBCG study.
Maria B Lyng, Anne-Vibeke Lænkholm, +3 authors, Henrik J Ditzel.
PLoS One, 2012 May 25; 7(5). PMID: 22623953    Free PMC article.
The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis.
P Hadji, R Coleman, M Gnant, J Green.
Ann Oncol, 2012 Jun 26; 23(11). PMID: 22730099    Free PMC article.
Defining the aromatase inhibitor musculoskeletal syndrome: a prospective study.
Ora Singer, Tessa Cigler, +5 authors, Lisa A Mandl.
Arthritis Care Res (Hoboken), 2012 Jun 26; 64(12). PMID: 22730307    Free PMC article.
Low Bone Mineral Density in Middle-Aged Breast Cancer Survivors: Prevalence and Associated Factors.
Délio Marques Conde, Lúcia Costa-Paiva, Edson Zangiacomi Martinez, Aarão Mendes Pinto-Neto.
Breast Care (Basel), 2012 Jun 29; 7(2). PMID: 22740798    Free PMC article.
High-dose toremifene as first-line treatment of metastatic breast cancer resistant to adjuvant aromatase inhibitor: A multicenter phase II study.
Masataka Sawaki, Masaki Wada, +7 authors, Tsuneo Imai.
Oncol Lett, 2012 Jun 29; 3(1). PMID: 22740857    Free PMC article.
Combinatorial drug therapy for cancer in the post-genomic era.
Bissan Al-Lazikani, Udai Banerji, Paul Workman.
Nat Biotechnol, 2012 Jul 12; 30(7). PMID: 22781697
Highly Cited. Review.
Patterns of bone density evaluation in a community population treated with aromatase inhibitors.
Jennifer A Ligibel, A James O'Malley, +3 authors, Nancy L Keating.
Breast Cancer Res Treat, 2012 Jul 14; 134(3). PMID: 22791365    Free PMC article.
Breast cancer as an acquired thrombophilic state.
Vasiliki Kyriazi.
J Breast Cancer, 2012 Jul 19; 15(2). PMID: 22807931    Free PMC article.
Breast cancer chemoprevention: old and new approaches.
Massimiliano Cazzaniga, Bernardo Bonanni.
J Biomed Biotechnol, 2012 Aug 02; 2012. PMID: 22851887    Free PMC article.
Combination anastrozole and fulvestrant in metastatic breast cancer.
Rita S Mehta, William E Barlow, +8 authors, Gabriel N Hortobagyi.
N Engl J Med, 2012 Aug 03; 367(5). PMID: 22853014    Free PMC article.
Highly Cited.
Role of aromatase inhibitors in the upfront adjuvant hormonal therapy of postmenopausal patients with breast cancer.
Jean-Marc Nabholtz, Marie-Ange Mouret-Reynier, +4 authors, Philippe Chollet.
Indian J Surg Oncol, 2010 Jan 01; 1(1). PMID: 22930614    Free PMC article.
Comparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: results of an experimental study.
Guler Yavas, Cagdas Yavas, +3 authors, Ozlem Ata.
Support Care Cancer, 2012 Sep 04; 21(3). PMID: 22941118
Effects of vaginal estrogens on serum estradiol levels in postmenopausal breast cancer survivors and women at risk of breast cancer taking an aromatase inhibitor or a selective estrogen receptor modulator.
Shannon Wills, Anita Ravipati, +5 authors, David A Decker.
J Oncol Pract, 2012 Sep 04; 8(3). PMID: 22942807    Free PMC article.
Preventive therapy for breast cancer.
Ivana Sestak, Jack Cuzick.
Curr Oncol Rep, 2012 Sep 14; 14(6). PMID: 22972612
Neoadjuvant treatment of breast cancer.
A M Thompson, S L Moulder-Thompson.
Ann Oncol, 2012 Sep 26; 23 Suppl 10. PMID: 22987968    Free PMC article.
Running on empty: cardiovascular reserve capacity and late effects of therapy in cancer survivorship.
Graeme J Koelwyn, Michel Khouri, +2 authors, Lee W Jones.
J Clin Oncol, 2012 Oct 10; 30(36). PMID: 23045598    Free PMC article.
Activation of rapid oestrogen signalling in aggressive human breast cancers.
Coralie Poulard, Isabelle Treilleux, +6 authors, Muriel Le Romancer.
EMBO Mol Med, 2012 Oct 16; 4(11). PMID: 23065768    Free PMC article.
Efficacy of adjuvant aromatase inhibitor in hormone receptor-positive postmenopausal breast cancer patients according to the body mass index.
M A N Sendur, S Aksoy, N Zengin, K Altundag.
Br J Cancer, 2012 Oct 27; 107(11). PMID: 23099804    Free PMC article.
Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer.
Heather Greenlee, Katherine D Crew, +7 authors, Dawn L Hershman.
Support Care Cancer, 2012 Nov 01; 21(4). PMID: 23111941    Free PMC article.
A multicenter prospective study to evaluate bone fracture related to adjuvant anastrozole in Japanese postmenopausal women with breast cancer: two-year interim analysis of Saitama Breast Cancer Clinical Study Group (SBCCSG-06).
Hideki Takeuchi, Hiroyuki Takei, +4 authors, Toshio Tabei.
Int J Clin Oncol, 2013 Jan 15; 19(1). PMID: 23314924
"Keeping the Boogie Man Away": Medication Self-Management among Women Receiving Anastrozole Therapy.
Karen Wickersham, Mary Beth Happ, Catherine M Bender.
Nurs Res Pract, 2013 Jan 18; 2012. PMID: 23326655    Free PMC article.
Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study.
Maria B Lyng, Anne-Vibeke Lænkholm, +4 authors, Henrik J Ditzel.
PLoS One, 2013 Jan 24; 8(1). PMID: 23342080    Free PMC article.
Tamoxifen-induced venothromboembolic events: exploring validation of putative genetic association.
Ingrid Glurich, Po-Huang Chyou, +2 authors, Adedayo A Onitilo.
Clin Med Res, 2013 Feb 16; 11(1). PMID: 23411630    Free PMC article.
Benefit and harms of new anti-cancer drugs.
Francisco E Vera-Badillo, Mustafa Al-Mubarak, Arnoud J Templeton, Eitan Amir.
Curr Oncol Rep, 2013 Feb 26; 15(3). PMID: 23435854
A randomized trial to assess the biological activity of short-term (pre-surgical) fulvestrant 500 mg plus anastrozole versus fulvestrant 500 mg alone or anastrozole alone on primary breast cancer.
John F R Robertson, J Michael Dixon, +6 authors, Julia M W Gee.
Breast Cancer Res, 2013 Mar 19; 15(2). PMID: 23497452    Free PMC article.
Efficacy of tamoxifen ± aminoglutethimide in normal weight and overweight postmenopausal patients with hormone receptor-positive breast cancer: an analysis of 1509 patients of the ABCSG-06 trial.
G Pfeiler, H Stöger, +19 authors, ABCSG.
Br J Cancer, 2013 Mar 21; 108(7). PMID: 23511562    Free PMC article.
Upregulation of AIB1, aromatase and ERα provides long-term estrogen-deprived human breast cancer cells with a mechanistic growth advantage for survival.
Syreeta L Tilghman, Gauri Sabnis, Angela M H Brodie.
Horm Mol Biol Clin Investig, 2011 Jan 01; 3(1). PMID: 23606920    Free PMC article.
Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer.
Nicola Napoli, Antonella Rastelli, +9 authors, Reina Armamento-Villareal.
Bone, 2013 May 07; 55(2). PMID: 23643682    Free PMC article.
Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.
Wei Lv, Jinzhong Liu, +2 authors, Mark Cushman.
J Med Chem, 2013 Jun 05; 56(11). PMID: 23731360    Free PMC article.
Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response.
Rinath M Jeselsohn, Lillian Werner, +11 authors, Steven E Come.
PLoS One, 2013 Jun 07; 8(5). PMID: 23741308    Free PMC article.
Pretreatment predictors of short-term nonadherence to oral hormonal therapy for women with breast cancer.
Karen E Wickersham, Susan M Sereika, Catherine M Bender.
Nurs Res, 2013 Jul 03; 62(4). PMID: 23817282    Free PMC article.
Luminal breast cancer: from biology to treatment.
Michail Ignatiadis, Christos Sotiriou.
Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035
Ki67-BCL2 index in prognosis of malignant peritoneal mesothelioma.
Krishna Pillai, Mohammad H Pourgholami, Terence C Chua, David L Morris.
Am J Cancer Res, 2013 Aug 27; 3(4). PMID: 23977450    Free PMC article.
SEOM clinical guidelines for the systemic treatment of early breast cancer 2013.
S Del Barco, E Ciruelos, +3 authors, SEOM.
Clin Transl Oncol, 2013 Aug 28; 15(12). PMID: 23979909
Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review.
Michael Retsky, Romano Demicheli, +7 authors, Jayant S Vaidya.
Curr Med Chem, 2013 Sep 03; 20(33). PMID: 23992307    Free PMC article.
A polymorphism at the 3'-UTR region of the aromatase gene is associated with the efficacy of the aromatase inhibitor, anastrozole, in metastatic breast carcinoma.
Lei Liu, Yu-Xian Bai, +12 authors, Qing-Yuan Zhang.
Int J Mol Sci, 2013 Sep 26; 14(9). PMID: 24065098    Free PMC article.
Starfish polysaccharides downregulate metastatic activity through the MAPK signaling pathway in MCF-7 human breast cancer cells.
Kyu-Shik Lee, Jin-Sun Shin, Kyung-Soo Nam.
Mol Biol Rep, 2013 Sep 26; 40(10). PMID: 24065532
Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes.
Yan Lu, Ming You, +6 authors, Ronald A Lubet.
Cancer Prev Res (Phila), 2013 Sep 27; 6(11). PMID: 24067424    Free PMC article.
Endocrine resistance in breast cancer: Current status and a perspective on the roles of miRNAs (Review).
Jichun Zhou, Rongyue Teng, +7 authors, Shuduo Xie.
Oncol Lett, 2013 Oct 19; 6(2). PMID: 24137320    Free PMC article.
Oestrogen receptors in breast cancer: basic mechanisms and clinical implications.
Cecilia Williams, Chin-Yo Lin.
Ecancermedicalscience, 2013 Nov 14; 7. PMID: 24222786    Free PMC article.
Expression of estrogen-related gene markers in breast cancer tissue predicts aromatase inhibitor responsiveness.
Irene Moy, Zhihong Lin, +3 authors, Serdar E Bulun.
PLoS One, 2013 Nov 14; 8(11). PMID: 24223121    Free PMC article.
Mesoporous silica nanoparticles as a breast-cancer targeting ultrasound contrast agent.
Andrew Milgroom, Miranda Intrator, +4 authors, Daewon Park.
Colloids Surf B Biointerfaces, 2013 Nov 26; 116. PMID: 24269054    Free PMC article.
Effect of prior chemotherapy regimens on the efficacy of endocrine therapy within a German cohort of the TEAM trial.
Michaela Bossart, Peyman Hadji, +2 authors, Annette Hasenburg.
J Cancer Res Clin Oncol, 2013 Nov 26; 140(1). PMID: 24271056
Tracking progesterone receptor-mediated actions in breast cancer.
Todd P Knutson, Carol A Lange.
Pharmacol Ther, 2013 Dec 03; 142(1). PMID: 24291072    Free PMC article.
Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy.
Deirdre P Cronin-Fenton, Per Damkier, Timothy L Lash.
Future Oncol, 2013 Dec 18; 10(1). PMID: 24328412    Free PMC article.
How do I recommend extended adjuvant hormonal therapy?
Amitkumar Mehta, John T Carpenter.
Curr Treat Options Oncol, 2013 Dec 18; 15(1). PMID: 24338340
Current and emerging treatment strategies for breast cancer-induced bone loss.
Stephanie L Hines.
Breast Cancer (Dove Med Press), 2010 Jan 01; 2. PMID: 24367168    Free PMC article.
Aromatase inhibitors in the treatment of breast cancer in post-menopausal female patients: an update.
Reva Schneider, Ayman Barakat, John Pippen, Cynthia Osborne.
Breast Cancer (Dove Med Press), 2011 Jan 01; 3. PMID: 24367181    Free PMC article.
Cyberknife radiotherapy and anastrozole for the treatment of advanced progressive low-grade papillary serous ovarian carcinoma: A case report.
Shandhini Raidoo, Sareena Singh, Raymond Redline, Robert Debernardo.
Gynecol Oncol Case Rep, 2013 Dec 29; 6. PMID: 24371718    Free PMC article.
Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer.
Rinath Jeselsohn, Roman Yelensky, +28 authors, Vincent A Miller.
Clin Cancer Res, 2014 Jan 09; 20(7). PMID: 24398047    Free PMC article.
Highly Cited.
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients.
Anna Tessari, Dario Palmieri, Serena Di Cosimo.
Pharmgenomics Pers Med, 2014 Jan 10; 7. PMID: 24403841    Free PMC article.
Breast cancer follow-up strategies in randomized phase III adjuvant clinical trials: a systematic review.
Isabella Sperduti, Patrizia Vici, +6 authors, Clara Natoli.
J Exp Clin Cancer Res, 2014 Jan 21; 32. PMID: 24438135    Free PMC article.
Systematic Review.
Adherence to adjuvant endocrine therapy in estrogen receptor-positive breast cancer patients with regular follow-up.
Renée Simon, Jean Latreille, +2 authors, Eric Bergeron.
Can J Surg, 2014 Jan 28; 57(1). PMID: 24461223    Free PMC article.
Clinical impact of delaying initiation of adjuvant chemotherapy in patients with breast cancer.
Debora de Melo Gagliato, Ana M Gonzalez-Angulo, +5 authors, Mariana Chavez-Macgregor.
J Clin Oncol, 2014 Jan 29; 32(8). PMID: 24470007    Free PMC article.
Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer.
M Arnedos, S Drury, +6 authors, M Dowsett.
Ann Oncol, 2014 Feb 15; 25(3). PMID: 24525703    Free PMC article.
Extended adjuvant tamoxifen for early breast cancer: a meta-analysis.
Mustafa Al-Mubarak, Ariadna Tibau, +4 authors, Eitan Amir.
PLoS One, 2014 Mar 04; 9(2). PMID: 24586311    Free PMC article.
Systematic Review.
Weight gain prior to entry into a weight-loss intervention study among overweight and obese breast cancer survivors.
Rebecca L Sedjo, Tim Byers, +5 authors, Cheryl L Rock.
J Cancer Surviv, 2014 Mar 07; 8(3). PMID: 24599421    Free PMC article.
Clinical utility of aromatase inhibitors as adjuvant treatment in postmenopausal early breast cancer.
Arturo Loaiza-Bonilla, Francisco Socola, Stefan Glück.
Clin Med Insights Womens Health, 2013 Jan 01; 6. PMID: 24665209    Free PMC article.
The effect of grape seed extract on estrogen levels of postmenopausal women: a pilot study.
Dietlind L Wahner-Roedler, Brent A Bauer, +3 authors, Janet E Olson.
J Diet Suppl, 2014 Mar 29; 11(2). PMID: 24670122    Free PMC article.
Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: a case control study.
Annette R Kodahl, Maria B Lyng, +4 authors, Henrik J Ditzel.
Mol Oncol, 2014 Apr 04; 8(5). PMID: 24694649    Free PMC article.
Highly Cited.
Second malignancies after breast cancer: The impact of adjuvant therapy.
Chunhui Dong, Ling Chen.
Mol Clin Oncol, 2014 Apr 29; 2(3). PMID: 24772296    Free PMC article.
Current strategies for the prevention of breast cancer.
Pooja Advani, Alvaro Moreno-Aspitia.
Breast Cancer (Dove Med Press), 2014 May 17; 6. PMID: 24833917    Free PMC article.
Predictive and prognostic value of the 21-gene recurrence score in hormone receptor-positive, node-positive breast cancer.
Adam M Brufsky.
Am J Clin Oncol, 2014 May 24; 37(4). PMID: 24853663    Free PMC article.
Systematic Review.
Frailty and adherence to adjuvant hormonal therapy in older women with breast cancer: CALGB protocol 369901.
Vanessa B Sheppard, Leigh Anne Faul, +14 authors, Jeanne S Mandelblatt.
J Clin Oncol, 2014 Jun 18; 32(22). PMID: 24934786    Free PMC article.
Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer.
Shuying Liu, Xiaolong Meng, +10 authors, Ana M González-Angulo.
Oncotarget, 2014 Jul 01; 5(19). PMID: 24979294    Free PMC article.
Status of adjuvant endocrine therapy for breast cancer.
Gaia Schiavon, Ian E Smith.
Breast Cancer Res, 2014 Jul 18; 16(2). PMID: 25032258    Free PMC article.
A nation-wide multicenter 10-year (1999-2008) retrospective clinical study of endocrine therapy for Chinese females with breast cancer.
Can Zhou, Jian jun He, +11 authors, Pin Zhang.
PLoS One, 2014 Jul 19; 9(7). PMID: 25036532    Free PMC article.
Aromatase inhibitors associated musculoskeletal disorders and bone fractures in postmenopausal breast cancer patients: a result from Chinese population.
Lu Xu, Jue Wang, Dan-Dan Xue, Wei He.
Med Oncol, 2014 Jul 25; 31(9). PMID: 25056205
Trends and present treatment patterns of early breast cancer in Southwest China.
Qiancheng Hu, Ting Luo, +5 authors, Hong Zheng.
Pathol Oncol Res, 2014 Aug 07; 21(2). PMID: 25096396
Effects of psoralens as anti-tumoral agents in breast cancer cells.
Maria Luisa Panno, Francesca Giordano.
World J Clin Oncol, 2014 Aug 13; 5(3). PMID: 25114850    Free PMC article.
Preventative therapies for healthy women at high risk of breast cancer.
Ivana Sestak.
Cancer Manag Res, 2014 Nov 08; 6. PMID: 25378950    Free PMC article.
Evaluation of Therapy Management and Patient Compliance in Postmenopausal Patients with Hormone Receptor-positive Breast Cancer Receiving Letrozole Treatment: The EvaluateTM Study.
P A Fasching, T Fehm, +47 authors, S Y Brucker.
Geburtshilfe Frauenheilkd, 2015 Jan 09; 74(12). PMID: 25568468    Free PMC article.
Periodontal health, perceived oral health, and dental care utilization of breast cancer survivors.
L Susan Taichman, Jennifer J Griggs, Marita R Inglehart.
J Public Health Dent, 2015 Feb 05; 75(2). PMID: 25648337    Free PMC article.
Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.
Wei Lv, Jinzhong Liu, +2 authors, Mark Cushman.
J Med Chem, 2015 Mar 10; 58(6). PMID: 25751283    Free PMC article.
Accumulation of p53 is prognostic for aromatase inhibitor resistance in early-stage postmenopausal patients with ER-positive breast cancer.
Xiao-Qing Jia, Qi Hong, +6 authors, Guang-Yu Liu.
Onco Targets Ther, 2015 Mar 15; 8. PMID: 25767399    Free PMC article.
Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy.
Feng Fu, Martin A Nowak, Sebastian Bonhoeffer.
PLoS Comput Biol, 2015 Mar 20; 11(3). PMID: 25789469    Free PMC article.
Approach to chemotherapy-associated thrombosis.
Peter Oppelt, Anthony Betbadal, Lalitha Nayak.
Vasc Med, 2015 Apr 03; 20(2). PMID: 25832603    Free PMC article.
Solitary uterine metastasis of invasive lobular carcinoma after adjuvant endocrine therapy: a case report.
Masafumi Toyoshima, Hideki Iwahashi, +10 authors, Kosuke Yoshinaga.
J Med Case Rep, 2015 Apr 17; 9. PMID: 25881005    Free PMC article.
Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations.
Balazs I Bodai, Phillip Tuso.
Perm J, 2015 Apr 23; 19(2). PMID: 25902343    Free PMC article.
Acupuncture for treating aromatase inhibitor-related arthralgia in breast cancer: a systematic review and meta-analysis.
Tsai-Ju Chien, Chia-Yu Liu, +2 authors, Chung-Hua Hsu.
J Altern Complement Med, 2015 Apr 29; 21(5). PMID: 25915433    Free PMC article.
Systematic Review.
5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial.
Nina D Wagner-Johnston, Jeff A Sloan, +7 authors, Charles L Loprinzi.
Cancer, 2015 May 02; 121(15). PMID: 25930719    Free PMC article.
Randomized Multicenter Placebo-Controlled Trial of Omega-3 Fatty Acids for the Control of Aromatase Inhibitor-Induced Musculoskeletal Pain: SWOG S0927.
Dawn L Hershman, Joseph M Unger, +10 authors, Carol M Moinpour.
J Clin Oncol, 2015 May 06; 33(17). PMID: 25940724    Free PMC article.
Effects of age on the detection and management of breast cancer.
Andrew McGuire, James A L Brown, +2 authors, Michael J Kerin.
Cancers (Basel), 2015 May 27; 7(2). PMID: 26010605    Free PMC article.
Highly Cited. Review.
Obesity and male breast cancer: provocative parallels?
Matthew P Humphries, V Craig Jordan, Valerie Speirs.
BMC Med, 2015 Jun 06; 13. PMID: 26044503    Free PMC article.
The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy.
Ping Fan, Philipp Y Maximov, +2 authors, V Craig Jordan.
Mol Cell Endocrinol, 2015 Jun 09; 418 Pt 3. PMID: 26052034    Free PMC article.
Ophthalmic Metastasis of Breast Cancer and Ocular Side Effects from Breast Cancer Treatment and Management: Mini Review.
Ilias Georgalas, Theodore Paraskevopoulos, +4 authors, Dimitris Papaconstantinou.
Biomed Res Int, 2015 Jun 17; 2015. PMID: 26078956    Free PMC article.
The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts.
Nipin S P, Pramod Darvin, +13 authors, Young Mok Yang.
BMC Cancer, 2015 Jun 19; 15. PMID: 26084564    Free PMC article.
Methods to Standardize a Multicenter Acupuncture Trial Protocol to Reduce Aromatase Inhibitor-related Joint Symptoms in Breast Cancer Patients.
Heather Greenlee, Katherine D Crew, +8 authors, Dawn L Hershman.
J Acupunct Meridian Stud, 2015 Jun 24; 8(3). PMID: 26100070    Free PMC article.
Application status of tamoxifen in endocrine therapy for early breast cancer.
Qiancheng Hu, Ting Luo, +3 authors, Hong Zheng.
Exp Ther Med, 2015 Jul 03; 9(6). PMID: 26136961    Free PMC article.
Hormone Therapy and its Effect on the Prognosis in Breast Cancer Patients.
C Rauh, F Schuetz, +18 authors, L Häberle.
Geburtshilfe Frauenheilkd, 2015 Jul 15; 75(6). PMID: 26166840    Free PMC article.
Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?
Wilbert Zwart, Huub Terra, Sabine C Linn, Sanne B Schagen.
Nat Rev Clin Oncol, 2015 Jul 22; 12(10). PMID: 26196252
Adjuvant endocrine therapy in pre- versus postmenopausal patients with steroid hormone receptor-positive breast cancer: results from a large population-based cohort of a cancer registry.
E C Inwald, M Koller, +7 authors, O Ortmann.
J Cancer Res Clin Oncol, 2015 Aug 09; 141(12). PMID: 26253629    Free PMC article.
Nipple-sparing Mastectomy in Breast Cancer: From an Oncologic Safety Perspective.
Nai-Si Huang, Jiong Wu.
Chin Med J (Engl), 2015 Aug 13; 128(16). PMID: 26265622    Free PMC article.
The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance.
Zsuzsanna Suba.
Drug Des Devel Ther, 2015 Aug 15; 9. PMID: 26273195    Free PMC article.
Molecular cancer prevention: Current status and future directions.
Karen Colbert Maresso, Kenneth Y Tsai, +3 authors, Ernest T Hawk.
CA Cancer J Clin, 2015 Aug 19; 65(5). PMID: 26284997    Free PMC article.
The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells.
Shaneabbas Raza, Joyce E Ohm, +4 authors, Othman Ghribi.
Mol Cell Biochem, 2015 Sep 10; 410(1-2). PMID: 26350565    Free PMC article.
Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors.
Maud Marques, Marie-Claude Beauchamp, +7 authors, Michael Witcher.
BMC Med, 2015 Sep 12; 13. PMID: 26354718    Free PMC article.
Treatment of Breast Cancer in the Elderly.
Rachel A Freedman.
Curr Oncol Rep, 2015 Sep 29; 17(11). PMID: 26412227
Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem.
Fotinos-Ioannis D Dimitrakopoulos, Anastasia Kottorou, +2 authors, Haralabos P Kalofonos.
J Breast Cancer, 2015 Oct 17; 18(3). PMID: 26472970    Free PMC article.
Anastrozole versus tamoxifen in postmenopausal women with ductal carcinoma in situ undergoing lumpectomy plus radiotherapy (NSABP B-35): a randomised, double-blind, phase 3 clinical trial.
Richard G Margolese, Reena S Cecchini, +16 authors, Norman Wolmark.
Lancet, 2015 Dec 22; 387(10021). PMID: 26686957    Free PMC article.
Patient-reported outcomes with anastrozole versus tamoxifen for postmenopausal patients with ductal carcinoma in situ treated with lumpectomy plus radiotherapy (NSABP B-35): a randomised, double-blind, phase 3 clinical trial.
Patricia A Ganz, Reena S Cecchini, +16 authors, Norman Wolmark.
Lancet, 2015 Dec 22; 387(10021). PMID: 26686960    Free PMC article.
Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.
Wei Lv, Jinzhong Liu, +4 authors, Mark Cushman.
J Med Chem, 2015 Dec 26; 59(1). PMID: 26704594    Free PMC article.
Impact of Adjuvant Endocrine Therapy on Quality of Life and Symptoms: Observational Data Over 12 Months From the Mind-Body Study.
Patricia A Ganz, Laura Petersen, Julienne E Bower, Catherine M Crespi.
J Clin Oncol, 2016 Jan 21; 34(8). PMID: 26786934    Free PMC article.
Neoadjuvant endocrine therapy in breast cancer: current role and future perspectives.
Romualdo Barroso-Sousa, Danilo D A Fonseca Reis Silva, Joao Victor Machado Alessi, Max Senna Mano.
Ecancermedicalscience, 2016 Jan 30; 10. PMID: 26823678    Free PMC article.
Fulvestrant decreases anastrozole drug concentrations when taken concurrently by patients with metastatic breast cancer treated on SWOG study S0226.
Daniel L Hertz, William E Barlow, +10 authors, James M Rae.
Br J Clin Pharmacol, 2016 Feb 10; 81(6). PMID: 26859101    Free PMC article.
Psychosocial factors related to non-persistence with adjuvant endocrine therapy among women with breast cancer: the Breast Cancer Quality of Care Study (BQUAL).
Dawn L Hershman, Lawrence H Kushi, +10 authors, Alfred I Neugut.
Breast Cancer Res Treat, 2016 Apr 18; 157(1). PMID: 27086286    Free PMC article.
Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients.
Takashi Takeshita, Yutaka Yamamoto, +5 authors, Hirotaka Iwase.
Oncotarget, 2016 Apr 23; 7(22). PMID: 27102299    Free PMC article.
Treatment Adherence and Its Impact on Disease-Free Survival in the Breast International Group 1-98 Trial of Tamoxifen and Letrozole, Alone and in Sequence.
Jacquie H Chirgwin, Anita Giobbie-Hurder, +12 authors, Beat Thürlimann.
J Clin Oncol, 2016 May 25; 34(21). PMID: 27217455    Free PMC article.
Highly Cited.
Evaluating the Survival Benefit Following Ovarian Function Suppression in Premenopausal Patients with Hormone Receptor Positive Early Breast Cancer.
Lin Qiu, Fangmeng Fu, +4 authors, Chuan Wang.
Sci Rep, 2016 May 28; 6. PMID: 27230285    Free PMC article.
Challenges in translating endpoints from trials to observational cohort studies in oncology.
Anne Gulbech Ording, Deirdre Cronin-Fenton, +4 authors, Henrik Toft Sørensen.
Clin Epidemiol, 2016 Jun 30; 8. PMID: 27354827    Free PMC article.
Fulvestrant inhibits growth of triple negative breast cancer and synergizes with tamoxifen in ERα positive breast cancer by up-regulation of ERβ.
Ameet K Mishra, Annelie Abrahamsson, Charlotta Dabrosin.
Oncotarget, 2016 Aug 04; 7(35). PMID: 27486755    Free PMC article.
Adjuvant systemic therapy in older women with breast cancer.
Julieta Leone, Bernardo Amadeo Leone, José Pablo Leone.
Breast Cancer (Dove Med Press), 2016 Aug 16; 8. PMID: 27524919    Free PMC article.
Comparison of the Ability of Different Clinical Treatment Scores to Estimate Prognosis in High-Risk Early Breast Cancer Patients: A Hellenic Cooperative Oncology Group Study.
Flora Stavridi, Konstantine T Kalogeras, +19 authors, George Fountzilas.
PLoS One, 2016 Oct 04; 11(10). PMID: 27695115    Free PMC article.
Polymorphisms in ABCB1 and CYP19A1 genes affect anastrozole plasma concentrations and clinical outcomes in postmenopausal breast cancer patients.
Guillermo Gervasini, Carlos Jara, +3 authors, Juan Antonio Carrillo.
Br J Clin Pharmacol, 2016 Oct 19; 83(3). PMID: 27747906    Free PMC article.
Surveillance Mammography in Older Patients With Breast Cancer-Can We Ever Stop?: A Review.
Rachel A Freedman, Nancy L Keating, +3 authors, Eric P Winer.
JAMA Oncol, 2016 Nov 29; 3(3). PMID: 27892991    Free PMC article.
Factors Influencing Decision-Making for or against Adjuvant and Neoadjuvant Chemotherapy in Postmenopausal Hormone Receptor-Positive Breast Cancer Patients in the EvAluate-TM Study.
Paul Gaß, Peter A Fasching, +47 authors, Christian R Löhberg.
Breast Care (Basel), 2016 Dec 07; 11(5). PMID: 27920623    Free PMC article.
Cardiotoxicity of aromatase inhibitors and tamoxifen in postmenopausal women with breast cancer: a systematic review and meta-analysis of randomized controlled trials.
F Khosrow-Khavar, K B Filion, +4 authors, L Azoulay.
Ann Oncol, 2016 Dec 22; 28(3). PMID: 27998966    Free PMC article.
Systematic Review.
Cancer Prevention: Lessons Learned and Future Directions.
Barbara K Dunn, Barnett S Kramer.
Trends Cancer, 2017 Feb 01; 2(12). PMID: 28138568    Free PMC article.
Extended Endocrine Therapy: Is 5 Years Enough?
Manali A Bhave, N Lynn Henry.
Curr Oncol Rep, 2017 Mar 03; 19(3). PMID: 28251491
Endocrine Therapy in the Current Management of Postmenopausal Estrogen Receptor-Positive Metastatic Breast Cancer.
Virginia G Kaklamani, William J Gradishar.
Oncologist, 2017 Mar 21; 22(5). PMID: 28314835    Free PMC article.
Role of steroid receptor and coregulator mutations in hormone-dependent cancers.
Anna C Groner, Myles Brown.
J Clin Invest, 2017 Apr 04; 127(4). PMID: 28368289    Free PMC article.
ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer.
Jianbo Zhang, Chen Zhou, +7 authors, Shuang Yang.
Cell Death Dis, 2017 Apr 07; 8(4). PMID: 28383555    Free PMC article.
A meta-analysis of randomized controlled trials comparing the efficacy and safety of anastrozole versus tamoxifen for breast cancer.
Yan Yang, Wei Pan, +2 authors, Xinchen Sun.
Oncotarget, 2017 Apr 19; 8(29). PMID: 28415634    Free PMC article.
Neoadjuvant Trials in ER+ Breast Cancer: A Tool for Acceleration of Drug Development and Discovery.
Angel L Guerrero-Zotano, Carlos L Arteaga.
Cancer Discov, 2017 May 13; 7(6). PMID: 28495849    Free PMC article.
Preventing invasive breast cancer using endocrine therapy.
Mangesh A Thorat, Jack Cuzick.
Breast, 2017 Jul 12; 34 Suppl 1. PMID: 28690107    Free PMC article.
Randomized trial of medroxyprogesterone acetate for the prevention of endometrial pathology from adjuvant tamoxifen for breast cancer: SWOG S9630.
Ronald K Potkul, Joseph M Unger, +13 authors, Kathy S Albain.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721383    Free PMC article.
Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.
Jennifer M Giltnane, Katherine E Hutchinson, +32 authors, Carlos L Arteaga.
Sci Transl Med, 2017 Aug 11; 9(402). PMID: 28794284    Free PMC article.
Clinical outcomes in ER+ HER2 -node-positive breast cancer patients who were treated according to the Recurrence Score results: evidence from a large prospectively designed registry.
Salomon M Stemmer, Mariana Steiner, +13 authors, Noa Ben-Baruch.
NPJ Breast Cancer, 2017 Sep 14; 3. PMID: 28900632    Free PMC article.
Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors in Breast Cancer.
Iman Doostan, Cansu Karakas, +7 authors, Khandan Keyomarsi.
Clin Cancer Res, 2017 Sep 28; 23(23). PMID: 28947566    Free PMC article.
Magnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers.
Ji Soo Choi, Dahye Yoon, +5 authors, Min Jung Kim.
Oncotarget, 2017 Oct 04; 8(38). PMID: 28969000    Free PMC article.
ER-positive breast cancer patients with more than three positive nodes or grade 3 tumors are at high risk of late recurrence after 5-year adjuvant endocrine therapy.
Fangbin Song, Jianbing Zhang, +6 authors, Junming Xu.
Onco Targets Ther, 2017 Oct 19; 10. PMID: 29042797    Free PMC article.
Evaluating the efficacy of post-surgery adjuvant therapies used for ductal carcinoma in situ patients: a network meta-analysis.
Li Wang, Yaoxiong Xia, +7 authors, Zhijie Liu.
Oncotarget, 2017 Nov 08; 8(45). PMID: 29108304    Free PMC article.
Effect of denosumab administration on low bone mineral density (T-score -1.0 to -2.5) in postmenopausal Japanese women receiving adjuvant aromatase inhibitors for non-metastatic breast cancer.
Katsuhiko Nakatsukasa, Hiroshi Koyama, +6 authors, Tetsuya Taguchi.
J Bone Miner Metab, 2017 Nov 09; 36(6). PMID: 29116414
A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.
Philipp Y Maximov, Balkees Abderrahman, +3 authors, V Craig Jordan.
Endocr Relat Cancer, 2017 Nov 23; 25(2). PMID: 29162647    Free PMC article.
Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES.
M C U Cheang, J M Bliss, +13 authors, PathIES Sub-Committee.
Breast Cancer Res Treat, 2017 Nov 28; 168(1). PMID: 29177605    Free PMC article.
Lumbar Scoliosis in Patients With Breast Cancer: Prevalence and Relationship With Breast Cancer Treatment, Age, Bone Mineral Density, and Body Mass Index.
Sangeun Jung, Mee Gang Kim, Jong In Lee.
Ann Rehabil Med, 2017 Dec 05; 41(5). PMID: 29201827    Free PMC article.
Aromatase inhibitors and the risk of colorectal cancer in postmenopausal women with breast cancer.
F Khosrow-Khavar, H Yin, +2 authors, L Azoulay.
Ann Oncol, 2018 Jan 03; 29(3). PMID: 29293897    Free PMC article.
Mitochondrial and caspase pathways are involved in the induction of apoptosis by nardosinen in MCF-7 breast cancer cell line.
Amirhosein Shahali, Mustafa Ghanadian, Seyyed Mehdi Jafari, Mahmoud Aghaei.
Res Pharm Sci, 2018 Feb 02; 13(1). PMID: 29387107    Free PMC article.
Randomized phase II study of anastrozole plus tegafur-uracil as neoadjuvant therapy for ER-positive breast cancer in postmenopausal Japanese women (Neo-ACET BC).
Takahiro Nakayama, Yasuaki Sagara, +8 authors, Shinzaburo Noguchi.
Cancer Chemother Pharmacol, 2018 Feb 23; 81(4). PMID: 29468454    Free PMC article.
Current Strategies of Endocrine Therapy in Elderly Patients with Breast Cancer.
Suk-Young Lee, Jae Hong Seo.
Biomed Res Int, 2018 Mar 28; 2018. PMID: 29581979    Free PMC article.
Aromatase inhibitors are associated with a higher fracture risk than tamoxifen: a systematic review and meta-analysis.
Olivia L Tseng, John J Spinelli, +3 authors, Martin G Dawes.
Ther Adv Musculoskelet Dis, 2018 Apr 06; 10(4). PMID: 29619093    Free PMC article.
Integration of Clinical Variables for the Prediction of Late Distant Recurrence in Patients With Estrogen Receptor-Positive Breast Cancer Treated With 5 Years of Endocrine Therapy: CTS5.
Mitch Dowsett, Ivana Sestak, +5 authors, Jack Cuzick.
J Clin Oncol, 2018 Apr 21; 36(19). PMID: 29676944    Free PMC article.
Clinical relevance of the 21-gene Recurrence Score® assay in treatment decisions for patients with node-positive breast cancer in the genomic era.
Eleftherios P Mamounas, Christy A Russell, +2 authors, Kathy S Albain.
NPJ Breast Cancer, 2018 Aug 30; 4. PMID: 30155517    Free PMC article.
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis.
Jaya Gautam, Suhrid Banskota, +4 authors, Byeong-Seon Jeong.
Exp Mol Med, 2018 Sep 07; 50(9). PMID: 30185799    Free PMC article.
Clinical outcomes and prognostic factors in patients with stage II-III breast cancer treated with neoadjuvant chemotherapy followed by surgery and postmastectomy radiation therapy in the modern treatment era.
Naomi Nakajima, Masahiko Oguchi, +7 authors, Shinji Ohno.
Adv Radiat Oncol, 2018 Sep 12; 3(3). PMID: 30202796    Free PMC article.
Clinical Trials for Ductal Carcinoma In Situ of the Breast.
Michelle S Han, Seema A Khan.
J Mammary Gland Biol Neoplasia, 2018 Sep 13; 23(4). PMID: 30206737
Prevention, Monitoring, and Management of Cardiac Dysfunction in Patients with Metastatic Breast Cancer.
Giuseppe Curigliano, Evandro de Azambuja, +3 authors, Carlo Maria Cipolla.
Oncologist, 2019 May 09; 24(11). PMID: 31064888    Free PMC article.
A Rare Case of Triple Positive Metachronous Breast Cancer.
Hardik S Chhatrala, John Khuu, Lara Zuberi.
J Investig Med High Impact Case Rep, 2019 Dec 21; 7. PMID: 31858813    Free PMC article.
Successful Targeted Therapies for Breast Cancer: the Worcester Foundation and Future Opportunities in Women's Health.
Balkees Abderrahman, V Craig Jordan.
Endocrinology, 2018 Jun 23; 159(8). PMID: 29931061    Free PMC article.
Acute arterial thrombosis during adjuvant Adriamycin-cyclophosphamide chemotherapy in a patient with early breast cancer: A case report.
Lee Chan Jang, Young Jin Choi.
Medicine (Baltimore), 2019 Dec 20; 98(50). PMID: 31852092    Free PMC article.
Prognostic Impact of Menopausal Hormone Therapy in Breast Cancer Differs According to Tumor Characteristics and Treatment.
Christopher Godina, Erik Ottander, +3 authors, Helena Jernström.
Front Oncol, 2020 Mar 03; 10. PMID: 32117735    Free PMC article.
Evaluation of the Incidence of Hematologic Malignant Neoplasms Among Breast Cancer Survivors in France.
Marie Joelle Jabagi, Norbert Vey, +3 authors, Rosemary Dray-Spira.
JAMA Netw Open, 2019 Jan 19; 2(1). PMID: 30657534    Free PMC article.
Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression.
Priya Bhardwaj, CheukMan C Au, +4 authors, Kristy A Brown.
J Steroid Biochem Mol Biol, 2019 Mar 10; 189. PMID: 30851382    Free PMC article.
Impact of Somatic Yoga and Meditation on Fall Risk, Function, and Quality of Life for Chemotherapy-Induced Peripheral Neuropathy Syndrome in Cancer Survivors.
Mary Lou Galantino, Robyn Tiger, +2 authors, Kim Wilson.
Integr Cancer Ther, 2019 May 28; 18. PMID: 31131640    Free PMC article.
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2.
Tanda M Dudenkov, Duan Liu, +18 authors, Richard M Weinshilboum.
Clin Pharmacol Ther, 2019 Jan 17; 106(1). PMID: 30648747    Free PMC article.
Aromatase Inhibitors and Risk of Arthritis and Carpal Tunnel Syndrome among Taiwanese Women with Breast Cancer: A Nationwide Claims Data Analysis.
Hsu-Chih Chien, Yea-Huei Kao Yang, +3 authors, Wei-Hsuan Lo-Ciganic.
J Clin Med, 2020 Feb 26; 9(2). PMID: 32092973    Free PMC article.
Endocrine Therapy for Ductal Carcinoma In Situ (DCIS) of the Breast with Breast Conserving Surgery (BCS) and Radiotherapy (RT): a Meta-Analysis.
Yanli Yan, Long Zhang, +10 authors, Juan Ren.
Pathol Oncol Res, 2018 Dec 01; 26(1). PMID: 30499075
Are aromatase inhibitors associated with higher myocardial infarction risk in breast cancer patients? A Medicare population-based study.
Sailaja Kamaraju, Yushu Shi, +3 authors, Joan Neuner.
Clin Cardiol, 2018 Nov 18; 42(1). PMID: 30443921    Free PMC article.
Neoadjuvant Endocrine Therapy in Breast Cancer: Current Knowledge and Future Perspectives.
Giacomo Barchiesi, Marco Mazzotta, +14 authors, Patrizia Vici.
Int J Mol Sci, 2020 May 21; 21(10). PMID: 32429381    Free PMC article.
Breast Cancer Survivorship, Quality of Life, and Late Toxicities.
Simone Nardin, Edoardo Mora, +6 authors, Alessandra Gennari.
Front Oncol, 2020 Jul 03; 10. PMID: 32612947    Free PMC article.
Complementary and alternative medicine and musculoskeletal pain in the first year of adjuvant aromatase inhibitor treatment in early breast cancer patients.
C C Hack, L Häberle, +42 authors, N Nabieva.
Breast, 2020 Jan 21; 50. PMID: 31958661    Free PMC article.
Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway.
Xiang Hu, Yiding Bian, +3 authors, Xiaoping Wan.
Exp Ther Med, 2020 Aug 04; 20(2). PMID: 32742375    Free PMC article.
Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Aradhana Rani, Justin Stebbing, Georgios Giamas, John Murphy.
Front Endocrinol (Lausanne), 2019 Jun 11; 10. PMID: 31178825    Free PMC article.
Highly Cited. Review.
A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach.
Anita Gul, Brain Leyland-Jones, Nandini Dey, Pradip De.
Am J Cancer Res, 2019 Jan 22; 8(12). PMID: 30662797    Free PMC article.
Multi-Drug/Gene NASH Therapy Delivery and Selective Hyperspectral NIR Imaging Using Chirality-Sorted Single-Walled Carbon Nanotubes.
Md Tanvir Hasan, Elizabeth Campbell, +4 authors, Anton V Naumov.
Cancers (Basel), 2019 Aug 17; 11(8). PMID: 31416250    Free PMC article.
Delayed initiation of adjuvant chemotherapy in older women with breast cancer.
Demetria Smith-Graziani, Xiudong Lei, +3 authors, Mariana Chavez-MacGregor.
Cancer Med, 2020 Aug 09; 9(19). PMID: 32767723    Free PMC article.
Analysis of the serial circulating tumor cell count during neoadjuvant chemotherapy in breast cancer patients.
Sungchan Gwark, Jisun Kim, +23 authors, Sei Hyun Ahn.
Sci Rep, 2020 Oct 17; 10(1). PMID: 33060768    Free PMC article.
Chrysoeriol Prevents TNFα-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells.
Dong Yeong Min, Euitaek Jung, +3 authors, Soon Young Shin.
Int J Mol Sci, 2020 Oct 16; 21(20). PMID: 33053908    Free PMC article.
A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102.
Elizabeth Cathcart-Rake, Paul Novotny, +14 authors, Charles L Loprinzi.
Support Care Cancer, 2020 May 07; 29(1). PMID: 32372176    Free PMC article.
Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial.
Ian Smith, John Robertson, +16 authors, Mitch Dowsett.
Lancet Oncol, 2020 Nov 06; 21(11). PMID: 33152284    Free PMC article.
Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio.
Clara Inkyung Lee, Siew Kee Low, +14 authors, Howard Gurney.
Breast, 2020 Nov 09; 54. PMID: 33161337    Free PMC article.
A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study.
N Martínez, M Herrera, +5 authors, M C Crespo.
Clin Transl Oncol, 2018 Oct 08; 21(4). PMID: 30293230
Identification and characterization of critical genes associated with tamoxifen resistance in breast cancer.
Kai Zhang, Kuikui Jiang, +8 authors, Shusen Wang.
PeerJ, 2020 Dec 19; 8. PMID: 33335811    Free PMC article.
Genomic Assays in Node Positive Breast Cancer Patients: A Review.
Maroun Bou Zerdan, Maryam Ibrahim, +2 authors, Hazem I Assi.
Front Oncol, 2021 Mar 06; 10. PMID: 33665165    Free PMC article.
Update Breast Cancer 2020 Part 5 - Moving Therapies From Advanced to Early Breast Cancer Patients.
Michael P Lux, Andreas Schneeweiss, +17 authors, Nina Ditsch.
Geburtshilfe Frauenheilkd, 2021 Apr 20; 81(4). PMID: 33867564    Free PMC article.