Journal Article
. 2002 Aug; 16(2):172-8.
doi: 10.1002/jmri.10140.

Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging

Yong Guo 1 You-Quan Cai  Zu-Long Cai  Yuan-Gui Gao  Ning-Yu An  Lin Ma  Srikanth Mahankali  Jia-Hong Gao  
  • PMID: 12203765
  •     224 citations


Purpose: To evaluate the value of diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions.

Materials And Methods: Fifty-two female subjects (mean age = 58 years, age range = 25-75 years) with histopathologically proven breast lesions underwent DWI of the breasts with a single-shot echo-planar imaging (EPI) sequence using large b values. The computed mean apparent diffusion coefficients (ADCs) of the breast lesions and cell density were then correlated.

Results: The ADCs varied substantially between benign breast lesions ((1.57 +/- 0.23) x 10(-3) mm(2)/second) and malignant breast lesions ((0.97 +/- 0.20) x 10(-3) mm(2)/second). In addition, the mean ADCs of the breast lesions correlated well with tumor cellularity (P < 0.01, r = -0.542).

Conclusion: The ADC would be an effective parameter in distinguishing between malignant and benign breast lesions. Further, tumor cellularity has a significant influence on the ADCs obtained in both benign and malignant breast tumors.

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Radiol Med, 2015 Feb 11; 120(8). PMID: 25665796
Evaluation of Kinetic Entropy of Breast Masses Initially Found on MRI using Whole-lesion Curve Distribution Data: Comparison with the Standard Kinetic Analysis.
Akiko Shimauchi, Hiroyuki Abe, +5 authors, Gillian M Newstead.
Eur Radiol, 2015 Feb 24; 25(8). PMID: 25698353
Diffusion-weighted MRI in the differential diagnosis of uterine endometrial cavity tumors.
Omer Karakas, Ekrem Karakas, +4 authors, Hakan Camuzcuoglu.
Wien Klin Wochenschr, 2015 Feb 25; 127(7-8). PMID: 25708066
MR mammography using diffusion-weighted imaging in evaluating breast cancer: a correlation with proliferation index.
Cristina Molinari, Paola Clauser, +5 authors, Massimo Bazzocchi.
Radiol Med, 2015 Mar 18; 120(10). PMID: 25776017
Can unenhanced breast MRI be used to decrease negative biopsy rates?
Sibel Kul, Şükrü Oğuz, İlker Eyüboğlu, Özlem Kömürcüoğlu.
Diagn Interv Radiol, 2015 Apr 04; 21(4). PMID: 25835081    Free PMC article.
Differential diagnosis of benign and malignant breast masses using diffusion-weighted magnetic resonance imaging.
Qinghua Min, Kangwei Shao, +4 authors, Jun Yang.
World J Surg Oncol, 2015 Apr 19; 13. PMID: 25889380    Free PMC article.
Assessment of tumor morphology on diffusion-weighted (DWI) breast MRI: Diagnostic value of reduced field of view DWI.
Maarten W Barentsz, Valentina Taviani, +6 authors, Bruce L Daniel.
J Magn Reson Imaging, 2015 Apr 29; 42(6). PMID: 25914178    Free PMC article.
Diagnosis of acute pancreatitis by diffusion-weighted magnetic resonance imaging.
İdil Güneş Tatar, Hasan Aydın, Kerim Bora Yılmaz, Baki Hekimoğlu.
Ulus Cerrahi Derg, 2015 May 02; 31(1). PMID: 25931944    Free PMC article.
Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials.
Dariya I Malyarenko, David Newitt, +9 authors, Thomas L Chenevert.
Magn Reson Med, 2015 May 06; 75(3). PMID: 25940607    Free PMC article.
Diffusion weighted magnetic resonance imaging and its recent trend-a survey.
Geetha Soujanya Chilla, Cher Heng Tan, Chenjie Xu, Chueh Loo Poh.
Quant Imaging Med Surg, 2015 Jun 02; 5(3). PMID: 26029644    Free PMC article.
Multiparametric and Multimodality Functional Radiological Imaging for Breast Cancer Diagnosis and Early Treatment Response Assessment.
Michael A Jacobs, Antonio C Wolff, +5 authors, Richard Wahl.
J Natl Cancer Inst Monogr, 2015 Jun 13; 2015(51). PMID: 26063885    Free PMC article.
Prognostication and response assessment in liver and pancreatic tumors: The new imaging.
Riccardo De Robertis, Paolo Tinazzi Martini, +9 authors, Mirko D'Onofrio.
World J Gastroenterol, 2015 Jun 17; 21(22). PMID: 26078555    Free PMC article.
Diffusion Magnetic Resonance Imaging: What Water Tells Us about Biological Tissues.
Denis Le Bihan, Mami Iima.
PLoS Biol, 2015 Jul 24; 13(7). PMID: 26204162    Free PMC article.
Correlation of tumor characteristics derived from DCE-MRI and DW-MRI with histology in murine models of breast cancer.
Stephanie L Barnes, Anna G Sorace, +2 authors, Thomas E Yankeelov.
NMR Biomed, 2015 Sep 04; 28(10). PMID: 26332194    Free PMC article.
Diffusion-weighted imaging of pancreatic cancer.
Riccardo De Robertis, Paolo Tinazzi Martini, +4 authors, Mirko D'Onofrio.
World J Radiol, 2015 Oct 31; 7(10). PMID: 26516428    Free PMC article.
Reproducibility of Apparent Diffusion Coefficient Measurements in Malignant Breast Masses.
Mijung Jang, Sun Mi Kim, +4 authors, Sung-Won Kim.
J Korean Med Sci, 2015 Nov 06; 30(11). PMID: 26539016    Free PMC article.
Diagnostic performance of ADCs in different ROIs for breast lesions.
Wei Zhang, Guan-Qiao Jin, +6 authors, Wei-Li Huang.
Int J Clin Exp Med, 2015 Nov 10; 8(8). PMID: 26550121    Free PMC article.
Effect of imaging parameters on the accuracy of apparent diffusion coefficient and optimization strategies.
Azim Celik.
Diagn Interv Radiol, 2015 Nov 18; 22(1). PMID: 26573977    Free PMC article.
Multiparametric MR Imaging of Breast Cancer.
Habib Rahbar, Savannah C Partridge.
Magn Reson Imaging Clin N Am, 2015 Nov 29; 24(1). PMID: 26613883    Free PMC article.
Qualitative and quantitative diffusion-weighted imaging of the breast at 3T - A useful adjunct to contrast-enhanced MRI in characterization of breast lesions.
Richa Bansal, Viral Shah, Bharat Aggarwal.
Indian J Radiol Imaging, 2016 Jan 12; 25(4). PMID: 26751011    Free PMC article.
Comparison between borderline ovarian tumors and carcinomas using semi-automated histogram analysis of diffusion-weighted imaging: focusing on solid components.
Rie Mimura, Fumi Kato, +7 authors, Hiroki Shirato.
Jpn J Radiol, 2016 Jan 23; 34(3). PMID: 26798066
[Selected clinically established and scientific techniques of diffusion-weighted MRI. In the context of imaging in oncology].
M T Freitag, S Bickelhaupt, +6 authors, F B Laun.
Radiologe, 2016 Jan 24; 56(2). PMID: 26801187
Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients, in-vitro and in-vivo reproducibility.
Maysam M Jafar, Arman Parsai, Marc E Miquel.
World J Radiol, 2016 Feb 03; 8(1). PMID: 26834942    Free PMC article.
Apparent diffusion coefficient value in invasive ductal carcinoma at 3.0 Tesla: is it correlated with prognostic factors?
Inanc Guvenc, Sinan Akay, +4 authors, Mustafa Tasar.
Br J Radiol, 2016 Feb 09; 89(1060). PMID: 26853508    Free PMC article.
MRI in the differential diagnosis of primary architectural distortion detected by mammography.
Lifang Si, Renyou Zhai, +3 authors, Tao Jiang.
Diagn Interv Radiol, 2016 Feb 24; 22(2). PMID: 26899149    Free PMC article.
3D microwave tomography of the breast using prior anatomical information.
Amir H Golnabi, Paul M Meaney, Keith D Paulsen.
Med Phys, 2016 Apr 03; 43(4). PMID: 27036589    Free PMC article.
Additional Value of Diffusion-Weighted Imaging to Evaluate Prognostic Factors of Breast Cancer: Correlation with the Apparent Diffusion Coefficient.
Eun Kyung Park, Kyu Ran Cho, +3 authors, Jeoung Won Bae.
Iran J Radiol, 2016 Apr 30; 13(1). PMID: 27127582    Free PMC article.
Potential of Diffusion-Weighted Imaging in the Characterization of Malignant, Benign, and Healthy Breast Tissues and Molecular Subtypes of Breast Cancer.
Uma Sharma, Rani G Sah, +5 authors, Naranamangalam R Jagannathan.
Front Oncol, 2016 Jun 01; 6. PMID: 27242965    Free PMC article.
Magnetic resonance imaging appearance of oxidized regenerated cellulose in breast cancer surgery.
Michela Giuliani, Rossella Rella, +10 authors, Lorenzo Bonomo.
Radiol Med, 2016 Jun 06; 121(9). PMID: 27262578
Value of apparent diffusion coefficient for predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas.
Lei Zhang, Sheng Xiang Rao, +3 authors, Meng Su Zeng.
Diagn Interv Radiol, 2016 Jun 11; 22(4). PMID: 27283593    Free PMC article.
Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions.
Tuğba Bozkurt Bostan, Gonca Koç, +3 authors, Orhan Oyar.
Balkan Med J, 2016 Jun 17; 33(3). PMID: 27308073    Free PMC article.
Diffusion-weighted imaging reflects variable cellularity and stromal density present in breast fibroadenomas.
Sana Parsian, Nadia V Giannakopoulos, +3 authors, Savannah C Partridge.
Clin Imaging, 2016 Jul 06; 40(5). PMID: 27379441    Free PMC article.
Magnetic resonance imaging features of idiopathic granulomatous mastitis: is there any contribution of diffusion-weighted imaging in the differential diagnosis?
Ravza Yilmaz, Ali Aslan Demir, +4 authors, Gulden Acunas.
Radiol Med, 2016 Jul 14; 121(11). PMID: 27406630
Hepatocellular Carcinoma and Diffusion-Weighted MRI: Detection and Evaluation of Treatment Response.
Jill S Gluskin, Fabrizio Chegai, +2 authors, Lorenzo Mannelli.
J Cancer, 2016 Jul 30; 7(11). PMID: 27471573    Free PMC article.
Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values.
Hubert Bickel, Katja Pinker, +7 authors, Pascal Baltzer.
Eur Radiol, 2016 Sep 01; 27(5). PMID: 27578047
Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment.
Danh Truong, Julieann Puleo, +3 authors, Mehdi Nikkhah.
Sci Rep, 2016 Sep 30; 6. PMID: 27678304    Free PMC article.
Diffusion-weighted breast MRI: Clinical applications and emerging techniques.
Savannah C Partridge, Noam Nissan, +2 authors, Eric E Sigmund.
J Magn Reson Imaging, 2016 Oct 01; 45(2). PMID: 27690173    Free PMC article.
Highly Cited. Review.
Whole-lesion apparent diffusion coefficient (ADC) metrics as a marker of breast tumour characterization-comparison between ADC value and ADC entropy.
Haralambos Bougias, Abraham Ghiatas, +2 authors, Alexandra Christou.
Br J Radiol, 2016 Oct 11; 89(1068). PMID: 27718592    Free PMC article.
Contribution of IVIM to Conventional Dynamic Contrast-Enhanced and Diffusion-Weighted MRI in Differentiating Benign from Malignant Breast Masses.
Qingjun Wang, Yong Guo, +3 authors, Yun Zhang.
Breast Care (Basel), 2016 Oct 11; 11(4). PMID: 27721712    Free PMC article.
Voxelwise analysis of simultaneously acquired and spatially correlated 18 F-fluorodeoxyglucose (FDG)-PET and intravoxel incoherent motion metrics in breast cancer.
Jason Ostenson, Akshat C Pujara, +13 authors, Eric E Sigmund.
Magn Reson Med, 2016 Oct 26; 78(3). PMID: 27779790    Free PMC article.
Microstructural models for diffusion MRI in breast cancer and surrounding stroma: an ex vivo study.
Colleen Bailey, Bernard Siow, +7 authors, David J Hawkes.
NMR Biomed, 2016 Dec 22; 30(2). PMID: 28000292    Free PMC article.
Three-dimensional Image-based Mechanical Modeling for Predicting the Response of Breast Cancer to Neoadjuvant Therapy.
Jared A Weis, Michael I Miga, Thomas E Yankeelov.
Comput Methods Appl Mech Eng, 2017 Jan 04; 314. PMID: 28042181    Free PMC article.
[Importance of diffusion imaging in liver metastases].
P Riffel, S O Schoenberg, J Krammer.
Radiologe, 2017 Mar 12; 57(5). PMID: 28283730
A mechanically coupled reaction-diffusion model that incorporates intra-tumoural heterogeneity to predict in vivo glioma growth.
David A Hormuth, Jared A Weis, +4 authors, Thomas E Yankeelov.
J R Soc Interface, 2017 Mar 24; 14(128). PMID: 28330985    Free PMC article.
Accuracy of diffusion kurtosis imaging in characterization of breast lesions.
Alexandra Christou, Abraham Ghiatas, +2 authors, Haralambos Bougias.
Br J Radiol, 2017 Apr 07; 90(1073). PMID: 28383279    Free PMC article.
An acetone-based phantom for quantitative diffusion MRI.
Xiaoke Wang, Scott B Reeder, Diego Hernando.
J Magn Reson Imaging, 2017 Apr 23; 46(6). PMID: 28432796    Free PMC article.
Rim sign and histogram analysis of apparent diffusion coefficient values on diffusion-weighted MRI in triple-negative breast cancer: Comparison with ER-positive subtype.
Yangsean Choi, Sung Hun Kim, +3 authors, Ahwon Lee.
PLoS One, 2017 May 26; 12(5). PMID: 28542297    Free PMC article.
Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging.
Stefanie J Hectors, Mathilde Wagner, +10 authors, Bachir Taouli.
Sci Rep, 2017 May 28; 7(1). PMID: 28550313    Free PMC article.
Correlation between arterial spin-labeling perfusion and histopathological vascular density of pediatric intracranial tumors.
Kazufumi Kikuchi, Akio Hiwatashi, +7 authors, Hiroshi Honda.
J Neurooncol, 2017 Sep 01; 135(3). PMID: 28856499
Potential Clinical Applications of 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Mammography in Breast Cancer.
Ihn-Ho Cho, Eun-Jung Kong.
Nucl Med Mol Imaging, 2017 Sep 08; 51(3). PMID: 28878847    Free PMC article.
Imaging Considerations and Interprofessional Opportunities in the Care of Breast Cancer Patients in the Neoadjuvant Setting.
Anna G Sorace, Sara Harvey, Anum Syed, Thomas E Yankeelov.
Semin Oncol Nurs, 2017 Sep 21; 33(4). PMID: 28927763    Free PMC article.
Correlation between apparent diffusion coefficient (ADC) and cellularity is different in several tumors: a meta-analysis.
Alexey Surov, Hans Jonas Meyer, Andreas Wienke.
Oncotarget, 2017 Sep 25; 8(35). PMID: 28938652    Free PMC article.
Highly Cited.
Preoperative indication for systemic therapy extended to patients with early-stage breast cancer using multiparametric 7-tesla breast MRI.
A M T Schmitz, W B Veldhuis, +8 authors, K G A Gilhuijs.
PLoS One, 2017 Sep 28; 12(9). PMID: 28949967    Free PMC article.
DWI in the Assessment of Breast Lesions.
Savannah C Partridge, Nita Amornsiripanitch.
Top Magn Reson Imaging, 2017 Sep 30; 26(5). PMID: 28961569    Free PMC article.
Magnetic Resonance Imaging after Breast Oncoplastic Surgery: An Update.
Silvia Gigli, Maria I Amabile, +6 authors, Laura Ballesio.
Breast Care (Basel), 2017 Oct 27; 12(4). PMID: 29070991    Free PMC article.
Diffusion weighted MRI and spectroscopy in invasive carcinoma of the breast at 3Tesla. Correlation with dynamic contrast enhancement and pathologic findings.
G Boulogianni, I Chryssogonidis, A Drevelegas.
Hippokratia, 2016 Jul 01; 20(3). PMID: 29097884    Free PMC article.
Relative enhanced diffusivity: noise sensitivity, protocol optimization, and the relation to intravoxel incoherent motion.
Peter T While, Jose R Teruel, +2 authors, Pål Erik Goa.
MAGMA, 2017 Nov 08; 31(3). PMID: 29110241
Visibility of mammographically occult breast cancer on diffusion-weighted MRI versus ultrasound.
Nita Amornsiripanitch, Habib Rahbar, +3 authors, Savannah C Partridge.
Clin Imaging, 2017 Nov 10; 49. PMID: 29120813    Free PMC article.
Integrated radiomic framework for breast cancer and tumor biology using advanced machine learning and multiparametric MRI.
Vishwa S Parekh, Michael A Jacobs.
NPJ Breast Cancer, 2017 Nov 21; 3. PMID: 29152563    Free PMC article.
A biomimetic tumor tissue phantom for validating diffusion-weighted MRI measurements.
Damien J McHugh, Feng-Lei Zhou, +4 authors, Geoffrey J M Parker.
Magn Reson Med, 2017 Nov 21; 80(1). PMID: 29154442    Free PMC article.
Intravoxel incoherent motion diffusion-weighted MR imaging of the liver using respiratory-cardiac double triggering.
Jinning Li, Caiyuan Zhang, +4 authors, Dengbin Wang.
Oncotarget, 2017 Dec 08; 8(55). PMID: 29212282    Free PMC article.
Short tau inversion recovery in breast diffusion-weighted imaging: signal-to-noise ratio and apparent diffusion coefficients using a breast phantom in comparison with spectral attenuated inversion recovery.
Tsukasa Yoshida, Atsushi Urikura, +4 authors, Yoichiro Hosokawa.
Radiol Med, 2017 Dec 13; 123(4). PMID: 29230679
Differentiation between phyllodes tumours and fibroadenomas using intravoxel incoherent motion magnetic resonance imaging: comparison with conventional diffusion-weighted imaging.
Hiroko Kawashima, Tosiaki Miyati, +4 authors, Toshifumi Gabata.
Br J Radiol, 2017 Dec 13; 91(1084). PMID: 29231040    Free PMC article.
Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer.
Anette Hauge, Catherine S Wegner, +3 authors, Einar K Rofstad.
Oncotarget, 2017 Dec 30; 8(62). PMID: 29285283    Free PMC article.
Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination.
Otso Arponen, Mazen Sudah, +4 authors, Ritva Vanninen.
Sci Rep, 2018 Jan 10; 8(1). PMID: 29311709    Free PMC article.
CEST-Dixon for human breast lesion characterization at 3 T: A preliminary study.
Shu Zhang, Stephen Seiler, +5 authors, Elena Vinogradov.
Magn Reson Med, 2018 Jan 13; 80(3). PMID: 29322559    Free PMC article.
Apparent diffusion coefficient mapping using diffusion-weighted MRI: impact of background parenchymal enhancement, amount of fibroglandular tissue and menopausal status on breast cancer diagnosis.
Joao V Horvat, Manuela Durando, +7 authors, Sunitha B Thakur.
Eur Radiol, 2018 Jan 14; 28(6). PMID: 29330631    Free PMC article.
Retrospective analysis of the utility of multiparametric MRI for differentiating between benign and malignant breast lesions in women in China.
Wei Xiong Fan, Xiao Feng Chen, +6 authors, Shuai Li.
Medicine (Baltimore), 2018 Jan 26; 97(4). PMID: 29369183    Free PMC article.
Stromal fibrosis: imaging features with diagnostic contribution of diffusion-weighted MRI.
Ravza Yilmaz, Zuhal Bayramoglu, +4 authors, Gulden Acunas.
Br J Radiol, 2018 Feb 02; 91(1085). PMID: 29388800    Free PMC article.
Biophysical Modeling of In Vivo Glioma Response After Whole-Brain Radiation Therapy in a Murine Model of Brain Cancer.
David A Hormuth, Jared A Weis, +3 authors, Thomas E Yankeelov.
Int J Radiat Oncol Biol Phys, 2018 Feb 06; 100(5). PMID: 29398129    Free PMC article.
Correlation between electrical conductivity and apparent diffusion coefficient in breast cancer: effect of necrosis on magnetic resonance imaging.
Soo-Yeon Kim, Jaewook Shin, +5 authors, Min Jung Kim.
Eur Radiol, 2018 Mar 08; 28(8). PMID: 29511804
Apparent Diffusion Coefficient to Subdivide Breast Imaging Reporting and Data System Magnetic Resonance Imaging (BI-RADS-MRI) Category 4 Lesions.
Dandan Liu, Zhaogui Ba, +3 authors, Xiangxing Ma.
Med Sci Monit, 2018 Apr 13; 24. PMID: 29644993    Free PMC article.
Incorporating drug delivery into an imaging-driven, mechanics-coupled reaction diffusion model for predicting the response of breast cancer to neoadjuvant chemotherapy: theory and preliminary clinical results.
Angela M Jarrett, David A Hormuth, +3 authors, Thomas E Yankeelov.
Phys Med Biol, 2018 Apr 27; 63(10). PMID: 29697054    Free PMC article.
Diffusion tensor magnetic resonance imaging of breast cancer: associations between diffusion metrics and histological prognostic factors.
Jin You Kim, Jin Joo Kim, +4 authors, Heesung Park.
Eur Radiol, 2018 May 02; 28(8). PMID: 29713771
Correlation between minimum apparent diffusion coefficient values and the histological grade of breast invasive ductal carcinoma.
Suhong Zhao, Weihua Guo, +4 authors, Guangrui Shao.
Oncol Lett, 2018 Jun 01; 15(5). PMID: 29849809    Free PMC article.
Diffusion-weighted breast imaging.
K Deike-Hofmann, T Kuder, +5 authors, S Bickelhaupt.
Radiologe, 2018 Jul 14; 58(Suppl 1). PMID: 30003283
Discrimination of malignant and benign breast masses using automatic segmentation and features extracted from dynamic contrast-enhanced and diffusion-weighted MRI.
Xinhua Jiang, Fei Xie, +3 authors, Li Li.
Oncol Lett, 2018 Jul 17; 16(2). PMID: 30008832    Free PMC article.
Breast cancer screening programs: Review of merits, demerits, and recent recommendations practiced across the world.
Tajammal Abbas Shah, Shaista Salman Guraya.
J Microsc Ultrastruct, 2017 Apr 01; 5(2). PMID: 30023238    Free PMC article.
Motion-robust reconstruction of multishot diffusion-weighted images without phase estimation through locally low-rank regularization.
Yuxin Hu, Evan G Levine, +7 authors, Brian L Hargreaves.
Magn Reson Med, 2018 Oct 23; 81(2). PMID: 30346058    Free PMC article.
Feasibility study of dual parametric 2D histogram analysis of breast lesions with dynamic contrast-enhanced and diffusion-weighted MRI.
Yanqiong Chen, Bin Wu, +2 authors, Yajia Gu.
J Transl Med, 2018 Nov 25; 16(1). PMID: 30470241    Free PMC article.
Diffusion-weighted MRI of estrogen receptor-positive, HER2-negative, node-negative breast cancer: association between intratumoral heterogeneity and recurrence risk.
Jin You Kim, Jin Joo Kim, +8 authors, Robert Grimm.
Eur Radiol, 2019 Aug 07; 30(1). PMID: 31385051
Correlation between apparent diffusion coefficient values in breast magnetic resonance imaging and prognostic factors of breast invasive ductal carcinoma.
Ricardo Moutinho-Guilherme, Janeth Hercilia Oyola, +4 authors, Vicente Martínez de Vega.
Porto Biomed J, 2018 Aug 03; 4(1). PMID: 31595254    Free PMC article.
The diagnostic precision of apparent diffusion coefficient (ADC) in grading of malignant endometrial lesions compared with histopathological findings.
Mohammad M Gharibvand, Azar Ahmadzadeh, Fariba Asadi, Zahra Fazelinejad.
J Family Med Prim Care, 2019 Nov 20; 8(10). PMID: 31742171    Free PMC article.
Limited role of DWI with apparent diffusion coefficient mapping in breast lesions presenting as non-mass enhancement on dynamic contrast-enhanced MRI.
Daly Avendano, Maria Adele Marino, +10 authors, Katja Pinker.
Breast Cancer Res, 2019 Dec 06; 21(1). PMID: 31801635    Free PMC article.
Multiparametric deep learning tissue signatures for a radiological biomarker of breast cancer: Preliminary results.
Vishwa S Parekh, Katarzyna J Macura, +4 authors, Michael A Jacobs.
Med Phys, 2019 Oct 11; 47(1). PMID: 31598978    Free PMC article.
Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment.
Josanne Sophia de Maar, Alexandros Marios Sofias, +4 authors, Roel Deckers.
Theranostics, 2020 Feb 12; 10(4). PMID: 32042343    Free PMC article.
Utility of Diffusion-weighted Imaging to Decrease Unnecessary Biopsies Prompted by Breast MRI: A Trial of the ECOG-ACRIN Cancer Research Group (A6702).
Habib Rahbar, Zheng Zhang, +17 authors, Savannah C Partridge.
Clin Cancer Res, 2019 Jan 17; 25(6). PMID: 30647080    Free PMC article.
Diffusion tensor imaging for characterizing tumor microstructure and improving diagnostic performance on breast MRI: a prospective observational study.
Jing Luo, Daniel S Hippe, +3 authors, Savannah C Partridge.
Breast Cancer Res, 2019 Sep 06; 21(1). PMID: 31484577    Free PMC article.
MRI in Evaluation of Solitary Pulmonary Nodules.
Erdem Fatihoğlu, Suzan Biri, +2 authors, Pınar Nercis Koşar.
Turk Thorac J, 2019 Apr 09; 20(2). PMID: 30958979    Free PMC article.
Risk stratification of ductal carcinoma in situ using whole-lesion histogram analysis of the apparent diffusion coefficient.
Jin You Kim, Jin Joo Kim, +6 authors, Robert Grimm.
Eur Radiol, 2018 Aug 04; 29(2). PMID: 30073498
Differentiation of Breast Lesions and Distinguishing Their Histological Subtypes Using Diffusion-Weighted Imaging and ADC Values.
Jelena Maric, Jasmina Boban, +3 authors, Dragana Bogdanovic-Stojanovic.
Front Oncol, 2020 Apr 02; 10. PMID: 32232007    Free PMC article.
Semi-automatic segmentation from intrinsically-registered 18F-FDG-PET/MRI for treatment response assessment in a breast cancer cohort: comparison to manual DCE-MRI.
Maren Marie Sjaastad Andreassen, Pål Erik Goa, +7 authors, Neil Peter Jerome.
MAGMA, 2019 Sep 29; 33(2). PMID: 31562584    Free PMC article.
Diagnostic performance of breast tumor tissue selection in diffusion weighted imaging: A systematic review and meta-analysis.
M Wielema, M D Dorrius, +4 authors, P E Sijens.
PLoS One, 2020 May 07; 15(5). PMID: 32374781    Free PMC article.
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Apparent diffusion coefficient values may help predict which MRI-detected high-risk breast lesions will upgrade at surgical excision.
Safia Cheeney, Habib Rahbar, +3 authors, Savannah C Partridge.
J Magn Reson Imaging, 2017 Feb 10; 46(4). PMID: 28181343    Free PMC article.
Magnetic resonance imaging semantic and quantitative features analyses: an additional diagnostic tool for breast phyllodes tumors.
Wenjuan Ma, Xinpeng Guo, +8 authors, Chao Zhang.
Am J Transl Res, 2020 Jun 09; 12(5). PMID: 32509202    Free PMC article.
Association among T2 signal intensity, necrosis, ADC and Ki-67 in estrogen receptor-positive and HER2-negative invasive ductal carcinoma.
Soo-Yeon Kim, Eun-Kyung Kim, +4 authors, Min Jung Kim.
Magn Reson Imaging, 2018 Sep 03; 54. PMID: 30172938    Free PMC article.
An adjoint-based method for a linear mechanically-coupled tumor model: Application to estimate the spatial variation of murine glioma growth based on diffusion weighted magnetic resonance imaging.
Xinzeng Feng, David A Hormuth, Thomas E Yankeelov.
Comput Mech, 2019 Mar 19; 63(2). PMID: 30880856    Free PMC article.
Role of apparent diffusion coefficient as a biomarker in the evaluation of cervical cancer.
Sunita Dashottar, T Preeth Pany, Nishant Lohia.
Indian J Radiol Imaging, 2019 Apr 20; 29(1). PMID: 31000938    Free PMC article.
Monitoring the Early Antiproliferative Effect of the Analgesic-Antitumor Peptide, BmK AGAP on Breast Cancer Using Intravoxel Incoherent Motion With a Reduced Distribution of Four b-Values.
Natacha Raissa Doudou, Sylvanus Kampo, +6 authors, Shaowu Wang.
Front Physiol, 2019 Jul 12; 10. PMID: 31293432    Free PMC article.
A Clinical Approach to Diffusion-Weighted Magnetic Resonance Imaging in Evaluating Chest Wall Invasion of Breast Tumors.
Naziya Samreen, Christine Lee, +5 authors, Katrina N Glazebrook.
J Clin Imaging Sci, 2019 Aug 27; 9. PMID: 31448162    Free PMC article.
Diagnostic value of diffusion-weighted imaging-derived apparent diffusion coefficient and its association with histological prognostic factors in breast cancer.
Congcong Ren, Yu Zou, Xiaodan Zhang, Kui Li.
Oncol Lett, 2019 Aug 28; 18(3). PMID: 31452808    Free PMC article.
Diffusion-weighted imaging of the breast: current status as an imaging biomarker and future role.
Julia Camps-Herrero.
BJR Open, 2019 Mar 08; 1(1). PMID: 33178933    Free PMC article.
Clinical and technical considerations for high quality breast MRI at 3 Tesla.
Habib Rahbar, Savannah C Partridge, +2 authors, Constance D Lehman.
J Magn Reson Imaging, 2013 Mar 26; 37(4). PMID: 23526757    Free PMC article.
Mechanically Coupled Reaction-Diffusion Model to Predict Glioma Growth: Methodological Details.
David A Hormuth, Stephanie L Eldridge, +2 authors, Thomas E Yankeelov.
Methods Mol Biol, 2018 Jan 19; 1711. PMID: 29344892    Free PMC article.
How to Improve the Conspicuity of Breast Tumors on Computed High b-value Diffusion-weighted Imaging.
Takayuki Tamura, Miyuki Takasu, +5 authors, Kazuo Awai.
Magn Reson Med Sci, 2018 Jul 18; 18(2). PMID: 30012905    Free PMC article.
Mean Apparent Diffusion Coefficient Is a Sufficient Conventional Diffusion-weighted MRI Metric to Improve Breast MRI Diagnostic Performance: Results from the ECOG-ACRIN Cancer Research Group A6702 Diffusion Imaging Trial.
Elizabeth S McDonald, Justin Romanoff, +20 authors, Savannah C Partridge.
Radiology, 2020 Nov 18; 298(1). PMID: 33201788    Free PMC article.
Diffusion-Weighted Magnetic Resonance Imaging of the Breast: Standardization of Image Acquisition and Interpretation.
Su Hyun Lee, Hee Jung Shin, Woo Kyung Moon.
Korean J Radiol, 2020 Sep 10; 22(1). PMID: 32901461    Free PMC article.
Evaluation of DWI and ADC Sequences' Diagnostic Values in Benign and Malignant Pulmonary Lesions.
Masoud Mahdavi Rashed, Sirous Nekooei, +2 authors, Alireza Khadembashi.
Turk Thorac J, 2020 Dec 23; 21(6). PMID: 33352094    Free PMC article.
Normalized apparent diffusion coefficient: a novel paradigm for characterization of endometrial and subendometrial lesions.
Zainab Vora, Smita Manchanda, +6 authors, Maroof Ahmad Khan.
Br J Radiol, 2020 Oct 31; 94(1117). PMID: 33125267    Free PMC article.
Noninvasive Quantification of Cell Density in Three-Dimensional Gels by MRI.
Brian J Archer, Till Uberruck, +9 authors, Louis-S Bouchard.
IEEE Trans Biomed Eng, 2018 Jul 22; 66(3). PMID: 30028689    Free PMC article.
Factors Affecting Image Quality and Lesion Evaluability in Breast Diffusion-weighted MRI: Observations from the ECOG-ACRIN Cancer Research Group Multisite Trial (A6702).
Jennifer G Whisenant, Justin Romanoff, +19 authors, Savannah C Partridge.
J Breast Imaging, 2021 Feb 06; 3(1). PMID: 33543122    Free PMC article.
q-Space Imaging Yields a Higher Effect Gradient to Assess Cellularity than Conventional Diffusion-weighted Imaging Methods at 3.0 T: A Pilot Study with Freshly Excised Whole-Breast Tumors.
Nicholas Senn, Yazan Masannat, +3 authors, Jiabao He.
Radiol Imaging Cancer, 2019 Sep 27; 1(1). PMID: 33778671    Free PMC article.
Candidate biomarkers of extravascular extracellular space: a direct comparison of apparent diffusion coefficient and dynamic contrast-enhanced MR imaging--derived measurement of the volume of the extravascular extracellular space in glioblastoma multiforme.
S J Mills, C Soh, +4 authors, A Jackson.
AJNR Am J Neuroradiol, 2009 Oct 24; 31(3). PMID: 19850765    Free PMC article.
Apparent diffusion coefficient calculated with relatively high b-values correlates with local failure of head and neck squamous cell carcinoma treated with radiotherapy.
M Hatakenaka, Y Shioyama, +8 authors, H Honda.
AJNR Am J Neuroradiol, 2011 Jul 23; 32(10). PMID: 21778248    Free PMC article.
Magnetic Resonance Imaging for Drug Development.
Jeong Kon Kim.
Adv Exp Med Biol, 2021 Apr 10; 1310. PMID: 33834438
Blood Oxygenation Level Dependent Magnetic Resonance Imaging (MRI), Dynamic Contrast Enhanced MRI, and Diffusion Weighted MRI for Benign and Malignant Breast Cancer Discrimination: A Preliminary Experience.
Roberta Fusco, Vincenza Granata, +6 authors, Mario Sansone.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34067721    Free PMC article.