Journal Article
. 2002 Sep; 298(5594):850-4.
doi: 10.1126/science.1076514.

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

Mark E Dudley 1 John R Wunderlich  Paul F Robbins  James C Yang  Patrick Hwu  Douglas J Schwartzentruber  Suzanne L Topalian  Richard Sherry  Nicholas P Restifo  Amy M Hubicki  Michael R Robinson  Mark Raffeld  Paul Duray  Claudia A Seipp  Linda Rogers-Freezer  Kathleen E Morton  Sharon A Mavroukakis  Donald E White  Steven A Rosenberg  
  • PMID: 12242449
  •     25 References
  •     943 citations


We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites. This led to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction. This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases.

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Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation.
Katia Perruccio, Antonella Tosti, +10 authors, Andrea Velardi.
Blood, 2005 Aug 27; 106(13). PMID: 16123217    Free PMC article.
High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation.
Yangbing Zhao, Zhili Zheng, +5 authors, Richard A Morgan.
Mol Ther, 2005 Sep 06; 13(1). PMID: 16140584    Free PMC article.
Fugetaxis: active movement of leukocytes away from a chemokinetic agent.
Fabrizio Vianello, Ivona T Olszak, Mark C Poznansky.
J Mol Med (Berl), 2005 Sep 06; 83(10). PMID: 16142473
Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines.
Gang Zhou, Charles G Drake, Hyam I Levitsky.
Blood, 2005 Sep 24; 107(2). PMID: 16179369    Free PMC article.
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells.
Luca Gattinoni, Steven E Finkelstein, +10 authors, Nicholas P Restifo.
J Exp Med, 2005 Oct 06; 202(7). PMID: 16203864    Free PMC article.
Highly Cited.
Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy.
R W Griffiths, D E Gilham, +4 authors, R E Hawkins.
Br J Cancer, 2005 Oct 14; 93(6). PMID: 16222313    Free PMC article.
Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells.
Christian S Hinrichs, Douglas C Palmer, Steven A Rosenberg, Nicholas P Restifo.
J Immunother, 2005 Oct 15; 28(6). PMID: 16224268    Free PMC article.
Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma.
Peter Attia, Ajay V Maker, +2 authors, Steven A Rosenberg.
J Immunother, 2005 Oct 15; 28(6). PMID: 16224276    Free PMC article.
Optimum in vitro expansion of human antigen-specific CD8 T cells for adoptive transfer therapy.
M Montes, N Rufer, +7 authors, S Leyvraz.
Clin Exp Immunol, 2005 Oct 20; 142(2). PMID: 16232216    Free PMC article.
Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.
Cyrille J Cohen, Zhili Zheng, +4 authors, Richard A Morgan.
J Immunol, 2005 Oct 21; 175(9). PMID: 16237072    Free PMC article.
Engineering T cells for cancer therapy.
W Mansoor, D E Gilham, F C Thistlethwaite, R E Hawkins.
Br J Cancer, 2005 Oct 28; 93(10). PMID: 16251873    Free PMC article.
Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.
Juhua Zhou, Xinglei Shen, +3 authors, Paul F Robbins.
J Immunol, 2005 Nov 08; 175(10). PMID: 16272366    Free PMC article.
Highly Cited.
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation.
Carolina Berger, Mary E Flowers, Edus H Warren, Stanley R Riddell.
Blood, 2005 Nov 12; 107(6). PMID: 16282341    Free PMC article.
Highly Cited.
Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing.
Li-Xin Wang, Rui Li, +7 authors, Hong-Ming Hu.
Cancer Res, 2005 Nov 17; 65(22). PMID: 16288050    Free PMC article.
Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy.
Lisa Marie Serrano, Timothy Pfeiffer, +10 authors, Laurence J N Cooper.
Blood, 2005 Dec 15; 107(7). PMID: 16352804    Free PMC article.
De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model.
Z Sheng Guo, Julie A Hong, +8 authors, David S Schrump.
Cancer Res, 2006 Jan 21; 66(2). PMID: 16424047    Free PMC article.
The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.
Leroy N Hwang, Zhiya Yu, Douglas C Palmer, Nicholas P Restifo.
Cancer Res, 2006 Jan 21; 66(2). PMID: 16424050    Free PMC article.
Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2.
Peter Attia, Daniel J Powell, +3 authors, Steven A Rosenberg.
J Immunother, 2006 Mar 15; 29(2). PMID: 16531821    Free PMC article.
Cancer immunotherapy using dendritic/tumour-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses.
S Homma, Y Sagawa, +2 authors, G Toda.
Clin Exp Immunol, 2006 Mar 18; 144(1). PMID: 16542363    Free PMC article.
Comment on "Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma".
Masoud H Manjili, Maciej Kmieciak, Johanna Keeler.
J Immunol, 2006 Apr 06; 176(8). PMID: 16585536    Free PMC article.
Adoptive immunotherapy for cancer: building on success.
Luca Gattinoni, Daniel J Powell, Steven A Rosenberg, Nicholas P Restifo.
Nat Rev Immunol, 2006 Apr 20; 6(5). PMID: 16622476    Free PMC article.
Highly Cited. Review.
High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT.
Katayoun Rezvani, Stephan Mielke, +8 authors, A John Barrett.
Blood, 2006 Apr 22; 108(4). PMID: 16627754    Free PMC article.
Highly Cited.
Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression.
Ralf-Holger Voss, Jürgen Kuball, +4 authors, Matthias Theobald.
Immunol Res, 2006 May 25; 34(1). PMID: 16720899
CD28 co-stimulation via tumour-specific chimaeric receptors induces an incomplete activation response in Epstein-Barr virus-specific effector memory T cells.
B Altvater, S Pscherer, +4 authors, C Rossig.
Clin Exp Immunol, 2006 Jun 01; 144(3). PMID: 16734614    Free PMC article.
Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation.
Persis J Amrolia, Giada Muccioli-Casadei, +16 authors, Malcolm K Brenner.
Blood, 2006 Jun 03; 108(6). PMID: 16741253    Free PMC article.
Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy.
Jianping Huang, Keith W Kerstann, +4 authors, Paul F Robbins.
J Immunol, 2006 Jun 06; 176(12). PMID: 16751420    Free PMC article.
Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts.
Ou Li, Xing Chang, +4 authors, Yang Liu.
J Exp Med, 2006 Jun 14; 203(7). PMID: 16769998    Free PMC article.
Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia.
Naoto Hirano, Marcus O Butler, +5 authors, Lee M Nadler.
Blood, 2006 Jun 17; 108(8). PMID: 16778141    Free PMC article.
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.
Ajay V Maker, James C Yang, +11 authors, Steven A Rosenberg.
J Immunother, 2006 Jun 27; 29(4). PMID: 16799341    Free PMC article.
T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity.
Jasper G van den Boorn, I Caroline Le Poole, Rosalie M Luiten.
Int Rev Immunol, 2006 Jul 05; 25(3-4). PMID: 16818373    Free PMC article.
CD8+ T-cell memory in tumor immunology and immunotherapy.
Christopher A Klebanoff, Luca Gattinoni, Nicholas P Restifo.
Immunol Rev, 2006 Jul 11; 211. PMID: 16824130    Free PMC article.
Highly Cited. Review.
Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs).
Barbara Savoldo, John A Goss, +12 authors, Helen E Heslop.
Blood, 2006 Jul 13; 108(9). PMID: 16835376    Free PMC article.
Regulatory T cells and innate immune regulation in tumor immunity.
Rong-Fu Wang.
Springer Semin Immunopathol, 2006 Jul 14; 28(1). PMID: 16838179
Cloning and expression of human membrane-bound and soluble engineered T cell receptors for immunotherapy.
Nehad M Alajez, Saman Eghtesad, Olivera J Finn.
J Biomed Biotechnol, 2006 Aug 03; 2006(2). PMID: 16883054    Free PMC article.
Improved overall survival in dendritic cell vaccination-induced immunoreactive subgroup of advanced melanoma patients.
Ruggero Ridolfi, Massimiliano Petrini, +5 authors, Angela Riccobon.
J Transl Med, 2006 Aug 18; 4. PMID: 16914047    Free PMC article.
A2A adenosine receptor protects tumors from antitumor T cells.
Akio Ohta, Elieser Gorelik, +12 authors, Michail Sitkovsky.
Proc Natl Acad Sci U S A, 2006 Aug 19; 103(35). PMID: 16916931    Free PMC article.
Highly Cited.
Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines.
Rachel H McMahan, Jennifer A McWilliams, +3 authors, Jill E Slansky.
J Clin Invest, 2006 Aug 26; 116(9). PMID: 16932807    Free PMC article.
Cancer regression in patients after transfer of genetically engineered lymphocytes.
Richard A Morgan, Mark E Dudley, +13 authors, Steven A Rosenberg.
Science, 2006 Sep 02; 314(5796). PMID: 16946036    Free PMC article.
Highly Cited.
Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability.
Cyrille J Cohen, Yangbing Zhao, +2 authors, Richard A Morgan.
Cancer Res, 2006 Sep 05; 66(17). PMID: 16951205    Free PMC article.
Highly Cited.
Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion.
Daniel J Powell, Mark E Dudley, +2 authors, Steven A Rosenberg.
J Immunol, 2006 Oct 24; 177(9). PMID: 17056585    Free PMC article.
Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes.
Laura A Johnson, Bianca Heemskerk, +5 authors, Steven A Rosenberg.
J Immunol, 2006 Oct 24; 177(9). PMID: 17056587    Free PMC article.
Highly Cited.
Presentation of tumor antigens by dendritic cells genetically modified with viral and nonviral vectors.
Michal Lotem, Yangbing Zhao, +4 authors, Maria R Parkhurst.
J Immunother, 2006 Oct 26; 29(6). PMID: 17063124    Free PMC article.
Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?
Pawel Muranski, Andrea Boni, +4 authors, Nicholas P Restifo.
Nat Clin Pract Oncol, 2006 Dec 02; 3(12). PMID: 17139318    Free PMC article.
Highly Cited. Review.
Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length.
Xinglei Shen, Juhua Zhou, +4 authors, Richard J Hodes.
J Immunother, 2007 Jan 02; 30(1). PMID: 17198091    Free PMC article.
Lymphoid reconstruction and vaccines.
Ronald E Gress, Krishna V Komanduri, Hermann Einsele, Laurence J N Cooper.
Biol Blood Marrow Transplant, 2007 Jan 16; 13(1 Suppl 1). PMID: 17222765    Free PMC article.
Generation and functional assessment of antigen-specific T cells stimulated by fusions of dendritic cells and allogeneic breast cancer cells.
Shigeo Koido, Yasuhiro Tanaka, Hisao Tajiri, Jianlin Gong.
Vaccine, 2007 Jan 24; 25(14). PMID: 17239504    Free PMC article.
In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor.
Alexandre Boissonnas, Luc Fetler, +2 authors, Sebastian Amigorena.
J Exp Med, 2007 Jan 31; 204(2). PMID: 17261634    Free PMC article.
Highly Cited.
To ablate or not to ablate? HSCs in the T cell driver's seat.
Claudio Anasetti, James J Mulé.
J Clin Invest, 2007 Feb 03; 117(2). PMID: 17273553    Free PMC article.
Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.
Claudia Wrzesinski, Chrystal M Paulos, +5 authors, Nicholas P Restifo.
J Clin Invest, 2007 Feb 03; 117(2). PMID: 17273561    Free PMC article.
CD4 cells can be more efficient at tumor rejection than CD8 cells.
Ainhoa Perez-Diez, Nathalie T Joncker, +4 authors, Polly Matzinger.
Blood, 2007 Mar 01; 109(12). PMID: 17327412    Free PMC article.
Highly Cited.
Tumor-specific T cells signal tumor destruction via the lymphotoxin beta receptor.
Hauke Winter, Natasja K van den Engel, +3 authors, Hong-Ming Hu.
J Transl Med, 2007 Mar 16; 5. PMID: 17355640    Free PMC article.
Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling.
Yangbing Zhao, Maria R Parkhurst, +6 authors, Richard A Morgan.
Cancer Res, 2007 Mar 17; 67(6). PMID: 17363559    Free PMC article.
Diversity of escape variant mutations in Simian virus 40 large tumor antigen (SV40 Tag) epitopes selected by cytotoxic T lymphocyte (CTL) clones.
Lawrence M Mylin, Todd D Schell, +6 authors, Satvir S Tevethia.
Virology, 2007 Mar 21; 364(1). PMID: 17368499    Free PMC article.
Vaccination regimens incorporating CpG-containing oligodeoxynucleotides and IL-2 generate antigen-specific antitumor immunity from T-cell populations undergoing homeostatic peripheral expansion after BMT.
James N Kochenderfer, Jessica L Simpson, Christopher D Chien, Ronald E Gress.
Blood, 2007 Mar 21; 110(1). PMID: 17371943    Free PMC article.
Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.
Megan M Suhoski, Tatiana N Golovina, +6 authors, Carl H June.
Mol Ther, 2007 Mar 22; 15(5). PMID: 17375070    Free PMC article.
Highly Cited.
Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen.
Jin Zheng, M Eric Kohler, +4 authors, Rimas J Orentas.
BMC Immunol, 2007 Apr 03; 8. PMID: 17397536    Free PMC article.
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells.
Stefanie Loeser, Karin Loser, +6 authors, Josef M Penninger.
J Exp Med, 2007 Apr 04; 204(4). PMID: 17403934    Free PMC article.
Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.
Cyrille J Cohen, Yong F Li, +3 authors, Richard A Morgan.
Cancer Res, 2007 Apr 19; 67(8). PMID: 17440104    Free PMC article.
Highly Cited.
Inability to mediate prolonged reduction of regulatory T Cells after transfer of autologous CD25-depleted PBMC and interleukin-2 after lymphodepleting chemotherapy.
Daniel J Powell, Christiaan R de Vries, +2 authors, Steven A Rosenberg.
J Immunother, 2007 Apr 26; 30(4). PMID: 17457218    Free PMC article.
Harnessing the immune system to treat cancer.
Nina Bhardwaj.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476342    Free PMC article.
Indoleamine 2,3-dioxygenase and tumor-induced tolerance.
David H Munn, Andrew L Mellor.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476344    Free PMC article.
Highly Cited. Review.
Development of TLR9 agonists for cancer therapy.
Arthur M Krieg.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476348    Free PMC article.
Highly Cited. Review.
Principles of adoptive T cell cancer therapy.
Carl H June.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476350    Free PMC article.
Highly Cited. Review.
Adoptive T cell therapy for cancer in the clinic.
Carl H June.
J Clin Invest, 2007 Jun 06; 117(6). PMID: 17549249    Free PMC article.
Highly Cited. Review.
Targeting transforming growth factor beta to enhance cancer immunotherapy.
T Hahn, E T Akporiaye.
Curr Oncol, 2007 Jun 20; 13(4). PMID: 17576455    Free PMC article.
Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone.
Jeffrey S Miller, Daniel J Weisdorf, +9 authors, Bruce R Blazar.
Blood, 2007 Jun 21; 110(7). PMID: 17579184    Free PMC article.
Maximizing CD8+ T cell responses elicited by peptide vaccines containing CpG oligodeoxynucleotides.
James N Kochenderfer, Christopher D Chien, Jessica L Simpson, Ronald E Gress.
Clin Immunol, 2007 Jun 23; 124(2). PMID: 17584532    Free PMC article.
Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.
Concetta Quintarelli, Juan F Vera, +7 authors, Gianpietro Dotti.
Blood, 2007 Jul 20; 110(8). PMID: 17638856    Free PMC article.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.
Mikael J Pittet, Jan Grimm, +6 authors, Ralph Weissleder.
Proc Natl Acad Sci U S A, 2007 Jul 21; 104(30). PMID: 17640914    Free PMC article.
Mobilizing the low-avidity T cell repertoire to kill tumors.
Rachel H McMahan, Jill E Slansky.
Semin Cancer Biol, 2007 Jul 27; 17(4). PMID: 17651986    Free PMC article.
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.
Chrystal M Paulos, Claudia Wrzesinski, +11 authors, Nicholas P Restifo.
J Clin Invest, 2007 Jul 28; 117(8). PMID: 17657310    Free PMC article.
Highly Cited.
Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice.
Timothy P Moran, Joseph E Burgents, +5 authors, Jonathan S Serody.
Vaccine, 2007 Aug 07; 25(36). PMID: 17675184    Free PMC article.
Failure of low-dose recombinant human IL-2 to support the survival of virus-specific CTL clones infused into severe combined immunodeficient foals: lack of correlation between in vitro activity and in vivo efficacy.
Robert H Mealey, Matt H Littke, +2 authors, Travis C McGuire.
Vet Immunol Immunopathol, 2007 Aug 31; 121(1-2). PMID: 17727961    Free PMC article.
Sensitivity and specificity of tritiated thymidine incorporation and ELISPOT assays in identifying antigen specific T cell immune responses.
Vivian Goodell, Corazon dela Rosa, +2 authors, Mary L Disis.
BMC Immunol, 2007 Sep 14; 8. PMID: 17850666    Free PMC article.
Adjuvant therapeutic vaccination in patients with non-small cell lung cancer made lymphopenic and reconstituted with autologous PBMC: first clinical experience and evidence of an immune response.
Dominik Rüttinger, Natasja K van den Engel, +8 authors, Rudolf A Hatz.
J Transl Med, 2007 Sep 18; 5. PMID: 17868452    Free PMC article.
Toll-like receptors in tumor immunotherapy.
Chrystal M Paulos, Andrew Kaiser, +11 authors, Nicholas P Restifo.
Clin Cancer Res, 2007 Sep 19; 13(18 Pt 1). PMID: 17875756    Free PMC article.
4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy.
Hua Zhang, Kristen M Snyder, +4 authors, Crystal L Mackall.
J Immunol, 2007 Sep 20; 179(7). PMID: 17878391    Free PMC article.
Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity.
Vincenzo Russo, Arcadi Cipponi, +9 authors, Catia Traversari.
J Clin Invest, 2007 Sep 22; 117(10). PMID: 17885685    Free PMC article.
Immune cell recruitment and cell-based system for cancer therapy.
Jian-Qing Gao, Naoki Okada, Tadanori Mayumi, Shinsaku Nakagawa.
Pharm Res, 2007 Sep 25; 25(4). PMID: 17891483    Free PMC article.
IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes.
Yongqing Li, Cassian Yee.
Blood, 2007 Oct 09; 111(1). PMID: 17921346    Free PMC article.
Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells.
Kanako Shimizu, Yuri Kurosawa, +2 authors, Shin-Ichiro Fujii.
J Exp Med, 2007 Oct 10; 204(11). PMID: 17923500    Free PMC article.
Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trials.
D L DiGiusto, L J N Cooper.
Cytotherapy, 2007 Oct 19; 9(7). PMID: 17943498    Free PMC article.
Chemotherapy and tumor immunity: an unexpected collaboration.
Leisha A Emens.
Front Biosci, 2007 Nov 06; 13. PMID: 17981543    Free PMC article.
Redirecting adaptive immunity against foreign antigens to tumors for cancer therapy.
Wenxian Hu, John J Davis, +8 authors, Bingliang Fang.
Cancer Biol Ther, 2007 Nov 08; 6(11). PMID: 17986853    Free PMC article.
T cell immune reconstitution following lymphodepletion.
Kirsten M Williams, Frances T Hakim, Ronald E Gress.
Semin Immunol, 2007 Nov 21; 19(5). PMID: 18023361    Free PMC article.
Highly Cited. Review.
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates.
Carolina Berger, Michael C Jensen, +3 authors, Stanley R Riddell.
J Clin Invest, 2007 Dec 07; 118(1). PMID: 18060041    Free PMC article.
Highly Cited.
Escape from suppression: tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation.
Paria Mirmonsef, Gladys Tan, +4 authors, Hyam I Levitsky.
Blood, 2007 Dec 08; 111(4). PMID: 18063750    Free PMC article.
Regulatory T cells and tumour immunity - observations in mice and men.
Awen Gallimore, Andrew Godkin.
Immunology, 2007 Dec 11; 123(2). PMID: 18067556    Free PMC article.
Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study.
Amy B Heimberger, Wei Sun, +11 authors, John H Sampson.
Neuro Oncol, 2007 Dec 15; 10(1). PMID: 18079360    Free PMC article.
Adoptive cell transfer therapy.
Mark E Dudley, Steven A Rosenberg.
Semin Oncol, 2007 Dec 18; 34(6). PMID: 18083376    Free PMC article.
T-cell receptor gene therapy of established tumors in a murine melanoma model.
John D Abad, Claudia Wrzensinski, +12 authors, Richard A Morgan.
J Immunother, 2007 Dec 25; 31(1). PMID: 18157006    Free PMC article.
The contributions of mass spectrometry to understanding of immune recognition by T lymphocytes.
Victor H Engelhard.
Int J Mass Spectrom, 2008 Jan 03; 259(1-3). PMID: 18167512    Free PMC article.
A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer.
Elisa Kieback, Jehad Charo, +2 authors, Wolfgang Uckert.
Proc Natl Acad Sci U S A, 2008 Jan 10; 105(2). PMID: 18182487    Free PMC article.
Generation and characterization of transgenic mice expressing a T-cell receptor specific for the tumour-associated antigen MDM2.
Shao-An Xue, Gavin M Bendle, Angelika Holler, Hans J Stauss.
Immunology, 2008 Jan 26; 124(3). PMID: 18217949    Free PMC article.
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain.
Robert M Prins, Chengyi J Shu, +9 authors, Linda M Liau.
Cancer Immunol Immunother, 2008 Feb 07; 57(9). PMID: 18253732    Free PMC article.
Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.
Lee A Selznick, Mohammed F Shamji, +3 authors, John Sampson.
Neurosurg Rev, 2008 Feb 09; 31(2). PMID: 18259789    Free PMC article.
Visualization of antigen-specific human cytotoxic T lymphocytes labeled with superparamagnetic iron-oxide particles.
Ambros J Beer, Konstantin Holzapfel, +7 authors, Helga Bernhard.
Eur Radiol, 2008 Feb 21; 18(6). PMID: 18286290
PD-L1: PD-1 interaction contributes to the functional suppression of T-cell responses to human uveal melanoma cells in vitro.
Wanhua Yang, Peter W Chen, +2 authors, Jerry Y Niederkorn.
Invest Ophthalmol Vis Sci, 2008 Feb 26; 49(6). PMID: 18296654    Free PMC article.
Loading of oncolytic vesicular stomatitis virus onto antigen-specific T cells enhances the efficacy of adoptive T-cell therapy of tumors.
J Qiao, H Wang, +12 authors, R G Vile.
Gene Ther, 2008 Feb 29; 15(8). PMID: 18305577    Free PMC article.
Adoptive cell transfer: a clinical path to effective cancer immunotherapy.
Steven A Rosenberg, Nicholas P Restifo, +2 authors, Mark E Dudley.
Nat Rev Cancer, 2008 Mar 21; 8(4). PMID: 18354418    Free PMC article.
Highly Cited. Review.
Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice.
Béatrice Breart, Fabrice Lemaître, Susanna Celli, Philippe Bousso.
J Clin Invest, 2008 Mar 22; 118(4). PMID: 18357341    Free PMC article.
Highly Cited.
Identification of HLA-A2 restricted T-cell epitopes within the conserved region of the immunoglobulin G heavy-chain in patients with multiple myeloma.
Sebastian Belle, Fang Han, +12 authors, Michael Hundemer.
Eur J Haematol, 2008 Mar 28; 81(1). PMID: 18363871    Free PMC article.
Immunotherapy of malignant brain tumors.
Duane A Mitchell, Peter E Fecci, John H Sampson.
Immunol Rev, 2008 Mar 28; 222. PMID: 18363995    Free PMC article.
Recombinant lentivector as a genetic immunization vehicle for antitumor immunity.
Yukai He, David Munn, Louis D Falo.
Expert Rev Vaccines, 2008 Apr 02; 6(6). PMID: 18377355    Free PMC article.
The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells.
Heather J Symons, Moshe Y Levy, +6 authors, Ephraim J Fuchs.
Biol Blood Marrow Transplant, 2008 Apr 16; 14(5). PMID: 18410892    Free PMC article.
Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation.
Hiroki Torikai, Yoshiki Akatsuka, +4 authors, Toshitada Takahashi.
Int J Hematol, 2008 Apr 17; 87(5). PMID: 18414982
Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions.
Paul F Robbins, Yong F Li, +12 authors, Steven A Rosenberg.
J Immunol, 2008 Apr 22; 180(9). PMID: 18424733    Free PMC article.
Highly Cited.
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.
Bianca Heemskerk, Ke Liu, +9 authors, Steven A Rosenberg.
Hum Gene Ther, 2008 May 01; 19(5). PMID: 18444786    Free PMC article.
Three phase II cytokine working group trials of gp100 (210M) peptide plus high-dose interleukin-2 in patients with HLA-A2-positive advanced melanoma.
Jeffrey A Sosman, Carole Carrillo, +13 authors, Marc S Ernstoff.
J Clin Oncol, 2008 May 10; 26(14). PMID: 18467720    Free PMC article.
Selective modification of antigen-specific T cells by RNA electroporation.
Duane A Mitchell, Isaac Karikari, +3 authors, John H Sampson.
Hum Gene Ther, 2008 May 13; 19(5). PMID: 18471037    Free PMC article.
Targeting tumors with LIGHT to generate metastasis-clearing immunity.
Ping Yu, Yang-Xin Fu.
Cytokine Growth Factor Rev, 2008 May 30; 19(3-4). PMID: 18508404    Free PMC article.
Noninvasive imaging of cell-mediated therapy for treatment of cancer.
Elizabeth J Akins, Purnima Dubey.
J Nucl Med, 2008 Jul 01; 49 Suppl 2. PMID: 18523073    Free PMC article.
Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma.
John H Sampson, Gary E Archer, +2 authors, Darell D Bigner.
Semin Immunol, 2008 Jun 10; 20(5). PMID: 18539480    Free PMC article.
An HLA-DR-degenerate epitope pool detects insulin-like growth factor binding protein 2-specific immunity in patients with cancer.
Kimberly R Kalli, Christopher J Krco, +11 authors, Keith L Knutson.
Cancer Res, 2008 Jun 19; 68(12). PMID: 18559537    Free PMC article.
In vivo functional efficacy of tumor-specific T cells expanded using HLA-Ig based artificial antigen presenting cells (aAPC).
Malarvizhi Durai, Christine Krueger, +4 authors, Jonathan P Schneck.
Cancer Immunol Immunother, 2008 Jun 20; 58(2). PMID: 18563409    Free PMC article.
Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.
Naomi N Hunder, Herschel Wallen, +7 authors, Cassian Yee.
N Engl J Med, 2008 Jun 21; 358(25). PMID: 18565862    Free PMC article.
Highly Cited.
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Gerald Willimsky, Melinda Czéh, +5 authors, Thomas Blankenstein.
J Exp Med, 2008 Jun 25; 205(7). PMID: 18573907    Free PMC article.
Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.
Carrie Gibbons, Megan Sykes.
Immunol Rev, 2008 Jul 11; 223. PMID: 18613846    Free PMC article.
A pilot study of consolidative immunotherapy in patients with high-risk pediatric sarcomas.
Crystal L Mackall, Eunice H Rhee, +11 authors, Lee J Helman.
Clin Cancer Res, 2008 Aug 05; 14(15). PMID: 18676758    Free PMC article.
TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation.
Moniek A de Witte, Gavin M Bendle, +7 authors, Ton N M Schumacher.
J Immunol, 2008 Aug 08; 181(4). PMID: 18684947    Free PMC article.
Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.
Jason E Foley, Jacopo Mariotti, +2 authors, Daniel H Fowler.
Biol Blood Marrow Transplant, 2008 Aug 30; 14(9). PMID: 18721759    Free PMC article.
Overcoming obstacles to the effective immunotherapy of human cancer.
Steven A Rosenberg.
Proc Natl Acad Sci U S A, 2008 Aug 30; 105(35). PMID: 18753635    Free PMC article.
CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors.
Angela M Tatum, Lawrence M Mylin, +5 authors, Todd D Schell.
J Immunol, 2008 Sep 05; 181(6). PMID: 18768900    Free PMC article.
Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy.
Khoi Q Tran, Juhua Zhou, +6 authors, Mark E Dudley.
J Immunother, 2008 Sep 10; 31(8). PMID: 18779745    Free PMC article.
Adoptive T-cell immunotherapy of chronic lymphocytic leukaemia.
Aaron E Foster, Malcolm K Brenner, Gianpietro Dotti.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790444    Free PMC article.
Immunotherapy targeting EBV-expressing lymphoproliferative diseases.
Catherine M Bollard, Laurence J Cooper, Helen E Heslop.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790446    Free PMC article.
Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantation.
Katayoun Rezvani, A John Barrett.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790448    Free PMC article.
Post-transplant adoptive T-cell immunotherapy.
Nicole A Aqui, Carl H June.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790452    Free PMC article.
Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation.
Kirsten M Williams, Ronald E Gress.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790456    Free PMC article.
Combination therapy with cisplatin and anti-4-1BB: synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity.
Young H Kim, Beom K Choi, +2 authors, Byoung S Kwon.
Cancer Res, 2008 Sep 17; 68(18). PMID: 18794112    Free PMC article.
Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
Mark E Dudley, James C Yang, +17 authors, Steven A Rosenberg.
J Clin Oncol, 2008 Sep 24; 26(32). PMID: 18809613    Free PMC article.
Highly Cited.
Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors.
Joshua D Brody, Matthew J Goldstein, Debra K Czerwinski, Ronald Levy.
Blood, 2008 Sep 25; 113(1). PMID: 18812472    Free PMC article.
FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions.
Mojgan Ahmadzadeh, Aloisio Felipe-Silva, +4 authors, Steven A Rosenberg.
Blood, 2008 Sep 30; 112(13). PMID: 18820132    Free PMC article.
Use of biological therapy to enhance both virotherapy and adoptive T-cell therapy for cancer.
Timothy Kottke, Rosa M Diaz, +12 authors, Richard G Vile.
Mol Ther, 2008 Oct 02; 16(12). PMID: 18827807    Free PMC article.
Does chemotherapy modify the immune surveillance of hematological malignancies?
A J Barrett, B N Savani.
Leukemia, 2008 Oct 03; 23(1). PMID: 18830260    Free PMC article.
Intratumoral dendritic cells and chemoradiation for the treatment of murine squamous cell carcinoma.
Jeffrey S Moyer, Ji Li, +2 authors, Alfred E Chang.
J Immunother, 2008 Oct 04; 31(9). PMID: 18832999    Free PMC article.
The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death.
Seung-Joo Lee, Meixiao Long, +2 authors, Anthony T Vella.
J Leukoc Biol, 2008 Oct 17; 85(1). PMID: 18923104    Free PMC article.
Combination of active specific immunotherapy or adoptive antibody or lymphocyte immunotherapy with chemotherapy in the treatment of cancer.
Tianqian Zhang, Dorothee Herlyn.
Cancer Immunol Immunother, 2008 Oct 18; 58(4). PMID: 18925393    Free PMC article.
MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency.
Yann Godet, Agnès Moreau-Aubry, +5 authors, Nathalie Labarriere.
J Exp Med, 2008 Oct 22; 205(11). PMID: 18936238    Free PMC article.
Use of high throughput qPCR screening to rapidly clone low frequency tumour specific T-cells from peripheral blood for adoptive immunotherapy.
Udai S Kammula, Oscar K Serrano.
J Transl Med, 2008 Oct 22; 6. PMID: 18937837    Free PMC article.
Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells.
Andrzej Wierzbicki, Margaret Gil, +5 authors, Danuta Kozbor.
J Immunol, 2008 Oct 23; 181(9). PMID: 18941255    Free PMC article.
Adoptive immunotherapy: good habits instilled at youth have long-term benefits.
Chrystal M Paulos, Megan M Suhoski, +10 authors, Carl H June.
Immunol Res, 2008 Oct 25; 42(1-3). PMID: 18949448    Free PMC article.
Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients.
Chrystal U Louis, Karin Straathof, +10 authors, Stephen Gottschalk.
Blood, 2008 Oct 31; 113(11). PMID: 18971421    Free PMC article.
Immunotherapy of autoimmunity and cancer: the penalty for success.
Rachel R Caspi.
Nat Rev Immunol, 2008 Nov 15; 8(12). PMID: 19008897    Free PMC article.
The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells.
Sara E Hamilton, Stephen C Jameson.
Proc Natl Acad Sci U S A, 2008 Nov 21; 105(47). PMID: 19020089    Free PMC article.
Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions.
Cecile Le Saout, Sandie Mennechet, Naomi Taylor, Javier Hernandez.
Proc Natl Acad Sci U S A, 2008 Nov 27; 105(49). PMID: 19033460    Free PMC article.
Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment.
Seunghee Kim-Schulze, Hong Sung Kim, +2 authors, Howard L Kaufman.
Mol Ther, 2008 Nov 27; 17(2). PMID: 19034262    Free PMC article.
Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.
Chengyi J Shu, Caius G Radu, +5 authors, Owen N Witte.
Int Immunol, 2008 Dec 25; 21(2). PMID: 19106231    Free PMC article.
Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells.
Maria R Parkhurst, Jayne Joo, +4 authors, Steven A Rosenberg.
Clin Cancer Res, 2009 Jan 02; 15(1). PMID: 19118044    Free PMC article.
Behavior of immune players in the tumor microenvironment.
Mikael J Pittet.
Curr Opin Oncol, 2009 Jan 07; 21(1). PMID: 19125019    Free PMC article.
Antitumor activity of T cells generated from lymph nodes draining the SEA-expressing murine B16 melanoma and secondarily activated with dendritic cells.
Jiyun Yu, Rong Tian, +6 authors, Qiao Li.
Int J Biol Sci, 2009 Jan 29; 5(2). PMID: 19173035    Free PMC article.
Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory.
Weiqing Jing, Jill A Gershan, Bryon D Johnson.
Blood, 2009 Feb 03; 113(18). PMID: 19182203    Free PMC article.
Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2.
Hanh K Le, Laura Graham, +3 authors, Harry Douglas Bear.
Cancer Immunol Immunother, 2009 Feb 10; 58(10). PMID: 19198835    Free PMC article.
Adoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR.
Michelle L Dossett, Ryan M Teague, +4 authors, Philip D Greenberg.
Mol Ther, 2009 Feb 12; 17(4). PMID: 19209146    Free PMC article.
Use of tumour-responsive T cells as cancer treatment.
Mary L Disis, Helga Bernhard, Elizabeth M Jaffee.
Lancet, 2009 Feb 24; 373(9664). PMID: 19231634    Free PMC article.
Immunomodulation in the treatment of haematological malignancies.
Michela Cesco-Gaspere, Emma Morris, Hans J Stauss.
Clin Exp Med, 2009 Feb 25; 9(2). PMID: 19238515
Evidence of systemic Th2-driven chronic inflammation in patients with metastatic melanoma.
Wendy K Nevala, Celine M Vachon, +4 authors, Melanoma Study Group of the Mayo Clinic Cancer Center.
Clin Cancer Res, 2009 Feb 26; 15(6). PMID: 19240164    Free PMC article.
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.
Juan F Vera, Valentina Hoyos, +9 authors, Gianpietro Dotti.
Mol Ther, 2009 Mar 05; 17(5). PMID: 19259067    Free PMC article.
Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes.
Stephanie Jones, Peter D Peng, +7 authors, Richard A Morgan.
Hum Gene Ther, 2009 Mar 07; 20(6). PMID: 19265475    Free PMC article.
Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma.
Herschel Wallen, John A Thompson, +3 authors, Cassian Yee.
PLoS One, 2009 Mar 10; 4(3). PMID: 19270751    Free PMC article.
Identification of novel helper epitopes of MAGE-A4 tumour antigen: useful tool for the propagation of Th1 cells.
T Ohkuri, D Wakita, +3 authors, T Nishimura.
Br J Cancer, 2009 Mar 12; 100(7). PMID: 19277034    Free PMC article.
Adoptive immunotherapy of cancer using CD4(+) T cells.
Pawel Muranski, Nicholas P Restifo.
Curr Opin Immunol, 2009 Mar 17; 21(2). PMID: 19285848    Free PMC article.
Highly Cited. Review.
Adoptive transfer of virus-specific and tumor-specific T cell immunity.
Carolina Berger, Cameron J Turtle, Michael C Jensen, Stanley R Riddell.
Curr Opin Immunol, 2009 Mar 24; 21(2). PMID: 19304470    Free PMC article.
Adoptive cell therapy for the treatment of patients with metastatic melanoma.
Steven A Rosenberg, Mark E Dudley.
Curr Opin Immunol, 2009 Mar 24; 21(2). PMID: 19304471    Free PMC article.
Highly Cited. Review.
Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha.
Sophie Viaud, Magali Terme, +9 authors, Nathalie Chaput.
PLoS One, 2009 Mar 26; 4(3). PMID: 19319200    Free PMC article.
Highly Cited.
Adoptive T cell therapy of cancer.
Ton N M Schumacher, Nicholas P Restifo.
Curr Opin Immunol, 2009 Mar 31; 21(2). PMID: 19328668    Free PMC article.
Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity.
Claudio G Brunstein, John E Wagner, +7 authors, Jeffrey S Miller.
Blood, 2009 Mar 31; 113(22). PMID: 19329778    Free PMC article.
Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.
Gabrielle A Rizzuto, Taha Merghoub, +9 authors, Alan N Houghton.
J Exp Med, 2009 Apr 01; 206(4). PMID: 19332877    Free PMC article.
Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma.
Darryl A Oble, Robert Loewe, Ping Yu, Martin C Mihm.
Cancer Immun, 2009 Apr 03; 9. PMID: 19338264    Free PMC article.
Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.
Petter S Woll, Bartosz Grzywacz, +4 authors, Dan S Kaufman.
Blood, 2009 Apr 15; 113(24). PMID: 19365083    Free PMC article.
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Marc Pellegrini, Thomas Calzascia, +12 authors, Tak W Mak.
Nat Med, 2009 Apr 28; 15(5). PMID: 19396174
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
Mojgan Ahmadzadeh, Laura A Johnson, +4 authors, Steven A Rosenberg.
Blood, 2009 May 09; 114(8). PMID: 19423728    Free PMC article.
Highly Cited.
Functions of γC cytokines in immune homeostasis: current and potential clinical applications.
Willem W Overwijk, Kimberly S Schluns.
Clin Immunol, 2009 May 12; 132(2). PMID: 19428306    Free PMC article.
Natural killer lysis receptor (NKLR)/NKLR-ligand matching as a novel approach for enhancing anti-tumor activity of allogeneic NK cells.
Gal Markel, Rachel Seidman, +8 authors, Jacob Schachter.
PLoS One, 2009 May 15; 4(5). PMID: 19440333    Free PMC article.
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.
Laura A Johnson, Richard A Morgan, +22 authors, Steven A Rosenberg.
Blood, 2009 May 20; 114(3). PMID: 19451549    Free PMC article.
Highly Cited.
Progress and challenges in the vaccine-based treatment of head and neck cancers.
Aldo Venuti.
J Exp Clin Cancer Res, 2009 May 29; 28. PMID: 19473517    Free PMC article.
Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer.
Seagal Teitz-Tennenbaum, Qiao Li, +4 authors, Alfred E Chang.
J Immunother, 2009 Jun 02; 32(6). PMID: 19483649    Free PMC article.
Anti-CTLA4 Antibody Clinical Trials in Melanoma.
Antoni Ribas.
Update Cancer Ther, 2007 Sep 01; 2(3). PMID: 19543441    Free PMC article.
Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells.
Gabriel A Kwong, Caius G Radu, +10 authors, James R Heath.
J Am Chem Soc, 2009 Jun 26; 131(28). PMID: 19552409    Free PMC article.
Toward effective immunotherapy for the treatment of malignant brain tumors.
Duane A Mitchell, John H Sampson.
Neurotherapeutics, 2009 Jun 30; 6(3). PMID: 19560742    Free PMC article.
Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.
Christopher A Klebanoff, Zhiya Yu, +3 authors, Nicholas P Restifo.
Blood, 2009 Jun 30; 114(9). PMID: 19561320    Free PMC article.
Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor.
James N Kochenderfer, Steven A Feldman, +5 authors, Steven A Rosenberg.
J Immunother, 2009 Jun 30; 32(7). PMID: 19561539    Free PMC article.
Highly Cited.
Lack of specific gamma-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation.
William R Burns, Zhili Zheng, Steven A Rosenberg, Richard A Morgan.
Blood, 2009 Jul 11; 114(14). PMID: 19589923    Free PMC article.
The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients.
Amy B Heimberger, John H Sampson.
Expert Opin Biol Ther, 2009 Jul 14; 9(8). PMID: 19591631    Free PMC article.
CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion.
Yolanda Nesbeth, Uciane Scarlett, +4 authors, Jose R Conejo-Garcia.
Cancer Res, 2009 Jul 16; 69(15). PMID: 19602595    Free PMC article.
Safety and immunologic effects of IL-15 administration in nonhuman primates.
Carolina Berger, Michael Berger, +4 authors, Stanley R Riddell.
Blood, 2009 Jul 17; 114(12). PMID: 19605850    Free PMC article.
Highly Cited.
Immunotherapy of distant metastatic disease.
D Schadendorf, S M Algarra, +9 authors, P Hersey.
Ann Oncol, 2009 Jul 28; 20 Suppl 6. PMID: 19617297    Free PMC article.
Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death.
Håkan Norell, Telma Martins da Palma, +10 authors, Shikhar Mehrotra.
Cancer Res, 2009 Jul 30; 69(15). PMID: 19638595    Free PMC article.
Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications.
Shuhong Han, Yuju Huang, +3 authors, Lung-Ji Chang.
J Hematol Oncol, 2009 Aug 08; 2. PMID: 19660111    Free PMC article.
Development of a Wilms' tumor antigen-specific T-cell receptor for clinical trials: engineered patient's T cells can eliminate autologous leukemia blasts in NOD/SCID mice.
Shao-An Xue, Liquan Gao, +6 authors, Hans J Stauss.
Haematologica, 2009 Aug 15; 95(1). PMID: 19679884    Free PMC article.
Cancer immunotherapy: the role regulatory T cells play and what can be done to overcome their inhibitory effects.
Ulf Petrausch, Christian H Poehlein, +20 authors, Bernard A Fox.
Curr Mol Med, 2009 Aug 20; 9(6). PMID: 19689294    Free PMC article.
T-cell seeding: neonatal transfer of anti-myelin basic protein T-cell lines renders Fischer rats susceptible later in life to the active induction of experimental autoimmune encephalitis.
Ilan Volovitz, Felix Mor, +6 authors, Irun Cohen.
Immunology, 2009 Aug 20; 128(1). PMID: 19689739    Free PMC article.
Cell carriers for oncolytic viruses: Fed Ex for cancer therapy.
Candice Willmon, Kevin Harrington, +3 authors, Richard Vile.
Mol Ther, 2009 Aug 20; 17(10). PMID: 19690519    Free PMC article.
Stimulation of lymphocyte anti-melanoma activity by co-cultured macrophages activated by complex homeopathic medication.
Fernando S F Guimarães, Ana P R Abud, +7 authors, Dorly F Buchi.
BMC Cancer, 2009 Aug 25; 9. PMID: 19698142    Free PMC article.
Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts.
Yongzhi Cui, Hua Zhang, +3 authors, Crystal L Mackall.
Blood, 2009 Aug 26; 114(18). PMID: 19704119    Free PMC article.
Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes.
Yozo Nakazawa, Leslie E Huye, +6 authors, Matthew H Wilson.
J Immunother, 2009 Sep 16; 32(8). PMID: 19752751    Free PMC article.
Autologous MUC1-specific Th1 effector cell immunotherapy induces differential levels of systemic TReg cell subpopulations that result in increased ovarian cancer patient survival.
Mark J Dobrzanski, Kathleen A Rewers-Felkins, +5 authors, Stephen E Wright.
Clin Immunol, 2009 Sep 19; 133(3). PMID: 19762283    Free PMC article.
Harnessing dendritic cells to generate cancer vaccines.
Karolina Palucka, Hideki Ueno, Joseph Fay, Jacques Banchereau.
Ann N Y Acad Sci, 2009 Sep 23; 1174. PMID: 19769741    Free PMC article.
The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor.
Phillip Scheinberg, Jan J Melenhorst, +8 authors, Daniel C Douek.
Blood, 2009 Sep 25; 114(24). PMID: 19776383    Free PMC article.
Liver resection for metastatic melanoma with postoperative tumor-infiltrating lymphocyte therapy.
R Taylor Ripley, Jeremy L Davis, +12 authors, Itzhak Avital.
Ann Surg Oncol, 2009 Sep 25; 17(1). PMID: 19777192    Free PMC article.
Immunotherapy of pediatric brain tumor patients should include an immunoprevention strategy: a medical hypothesis paper.
Lara Driggers, Jian-Gang Zhang, +3 authors, Martin R Jadus.
J Neurooncol, 2009 Oct 06; 97(2). PMID: 19802719    Free PMC article.
Depletion of tumor-induced Treg prior to reconstitution rescues enhanced priming of tumor-specific, therapeutic effector T cells in lymphopenic hosts.
Christian H Poehlein, Daniel P Haley, Edwin B Walker, Bernard A Fox.
Eur J Immunol, 2009 Oct 20; 39(11). PMID: 19839008    Free PMC article.
A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity.
Yangbing Zhao, Qiong J Wang, +7 authors, Richard A Morgan.
J Immunol, 2009 Oct 22; 183(9). PMID: 19843940    Free PMC article.
Highly Cited.
Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model.
Tai-Gyu Kim, Chang-Hyun Kim, +4 authors, Yong-Kil Hong.
Clin Vaccine Immunol, 2009 Nov 06; 17(1). PMID: 19889936    Free PMC article.
Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review.
P Dillon, N Thomas, N Sharpless, F Collichio.
Med Oncol, 2009 Nov 06; 27(4). PMID: 19890737    Free PMC article.
In vivo administration of artificial antigen-presenting cells activates low-avidity T cells for treatment of cancer.
Stefano Ugel, Alessia Zoso, +8 authors, Vincenzo Bronte.
Cancer Res, 2009 Nov 26; 69(24). PMID: 19934317    Free PMC article.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
William Humphries, Jun Wei, John H Sampson, Amy B Heimberger.
Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972    Free PMC article.
Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques.
Diane L Bolton, Jacob T Minang, +8 authors, Claes Ohlen.
J Immunol, 2009 Dec 02; 184(1). PMID: 19949089    Free PMC article.
Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection.
Jacob T Minang, Matthew T Trivett, +14 authors, Claes Ohlen.
J Immunol, 2009 Dec 02; 184(1). PMID: 19949091    Free PMC article.
Antitumor effect of mSurvivinThr34→Ala in murine colon carcinoma when administered intravenously.
Hong-xia Li, Xin-yu Zhao, +16 authors, Xia Zhao.
Med Oncol, 2009 Dec 02; 27(4). PMID: 19949901
Immunotherapy of childhood cancer: from biologic understanding to clinical application.
Alan S Wayne, Christian M Capitini, Crystal L Mackall.
Curr Opin Pediatr, 2009 Dec 03; 22(1). PMID: 19952749    Free PMC article.
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.
Claudia Wrzesinski, Chrystal M Paulos, +6 authors, Nicholas P Restifo.
J Immunother, 2009 Dec 03; 33(1). PMID: 19952961    Free PMC article.
Highly Cited.
The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade.
Lana E Kandalaft, Nathan Singh, +4 authors, George Coukos.
Gynecol Oncol, 2009 Dec 05; 116(2). PMID: 19959212    Free PMC article.
Increased plasma-immune cytokines throughout the high-dose melphalan-induced lymphodepletion in patients with multiple myeloma: a window for adoptive immunotherapy.
Maud Condomines, Jean-Luc Veyrune, +7 authors, Bernard Klein.
J Immunol, 2009 Dec 08; 184(2). PMID: 19966210    Free PMC article.
T cell sensitivity and the outcome of viral infection.
L J Walker, A K Sewell, P Klenerman.
Clin Exp Immunol, 2009 Dec 09; 159(3). PMID: 19968665    Free PMC article.
Novel immunotherapies.
Qing Yi.
Cancer J, 2009 Dec 17; 15(6). PMID: 20010170    Free PMC article.
Cancer vaccine development: designing tumor cells for greater immunogenicity.
Erica N Bozeman, Rangaiah Shashidharamurthy, +3 authors, Periasamy Selvaraj.
Front Biosci (Landmark Ed), 2009 Dec 29; 15(1). PMID: 20036822    Free PMC article.
CD34-based enrichment of genetically engineered human T cells for clinical use results in dramatically enhanced tumor targeting.
Håkan Norell, Yi Zhang, +10 authors, Michael I Nishimura.
Cancer Immunol Immunother, 2010 Jan 07; 59(6). PMID: 20052466    Free PMC article.
CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues.
Sadna Budhu, John D Loike, +5 authors, Samuel C Silverstein.
J Exp Med, 2010 Jan 13; 207(1). PMID: 20065066    Free PMC article.
Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens.
Edus H Warren, Nobuharu Fujii, +11 authors, Stanley R Riddell.
Blood, 2010 Jan 15; 115(19). PMID: 20071660    Free PMC article.
Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells.
Mohamed L Salem, Amir A Al-Khami, +3 authors, David J Cole.
J Immunol, 2010 Jan 20; 184(4). PMID: 20083664    Free PMC article.
Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice.
Randal K Gregg, Lisa Nichols, +2 authors, Victor H Engelhard.
J Immunol, 2010 Jan 20; 184(4). PMID: 20083666    Free PMC article.
Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype.
Zhi-Chun Ding, Bruce R Blazar, +2 authors, Gang Zhou.
Blood, 2010 Feb 02; 115(12). PMID: 20118405    Free PMC article.
Pilot study of sentinel-node-based adoptive immunotherapy in advanced colorectal cancer.
Mona Karlsson, Per Marits, +4 authors, Ola Winqvist.
Ann Surg Oncol, 2010 Feb 02; 17(7). PMID: 20119674    Free PMC article.
Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28.
Jacalyn Rosenblatt, Zekui Wu, +15 authors, David Avigan.
J Immunother, 2010 Feb 11; 33(2). PMID: 20145548    Free PMC article.
NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction.
Jeffrey S Miller, Edus H Warren, +9 authors, J H Frederik Falkenburg.
Biol Blood Marrow Transplant, 2010 Feb 16; 16(5). PMID: 20152921    Free PMC article.
Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs.
Takeshi Nakahara, Hiroshi Uchi, +7 authors, Alan N Houghton.
Blood, 2010 Feb 16; 115(22). PMID: 20154220    Free PMC article.
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
Sergio A Quezada, Tyler R Simpson, +9 authors, James P Allison.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156971    Free PMC article.
Highly Cited.
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
Ying Xie, Akgül Akpinarli, +6 authors, Paul Andrew Antony.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156973    Free PMC article.
Highly Cited.
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.
John C Markley, Michel Sadelain.
Blood, 2010 Mar 02; 115(17). PMID: 20190192    Free PMC article.
Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma.
Shari Pilon-Thomas, Amy Mackay, Nasreen Vohra, James J Mulé.
J Immunol, 2010 Mar 03; 184(7). PMID: 20194714    Free PMC article.
Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand.
Eileen M Higham, K Dane Wittrup, Jianzhu Chen.
J Immunol, 2010 Mar 05; 184(7). PMID: 20200275    Free PMC article.
Induction/engineering, detection, selection, and expansion of clinical-grade human antigen-specific CD8 cytotoxic T cell clones for adoptive immunotherapy.
Matjaz Jeras, Irena Bricl, Robert Zorec, Urban Svajger.
J Biomed Biotechnol, 2010 Mar 13; 2010. PMID: 20224660    Free PMC article.
Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.
Ken-ichi Matsuoka, Haesook T Kim, +9 authors, Jerome Ritz.
J Clin Invest, 2010 Apr 15; 120(5). PMID: 20389017    Free PMC article.
Highly Cited.
CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.
Yolanda C Nesbeth, Diana G Martinez, +4 authors, Jose R Conejo-Garcia.
J Immunol, 2010 Apr 20; 184(10). PMID: 20400704    Free PMC article.
Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen.
Edwin Motari, Xincheng Zheng, +4 authors, Peng George Wang.
Am J Biomed Sci, 2009 Jan 01; 1(1). PMID: 20407596    Free PMC article.
Peripheral Tolerization of Effector and Memory T Cells: Implications for Autoimmunity and Tumor-Immunity.
Adam J Adler.
Curr Immunol Rev, 2005 Jan 01; 1(1). PMID: 20411047    Free PMC article.
Immunotherapy approaches for malignant glioma from 2007 to 2009.
Laura A Johnson, John H Sampson.
Curr Neurol Neurosci Rep, 2010 Apr 29; 10(4). PMID: 20424975    Free PMC article.
Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model.
Eileen M Higham, Ching-Hung Shen, K Dane Wittrup, Jianzhu Chen.
J Immunol, 2010 Apr 30; 184(11). PMID: 20427765    Free PMC article.
Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.
Bipulendu Jena, Gianpietro Dotti, Laurence J N Cooper.
Blood, 2010 May 05; 116(7). PMID: 20439624    Free PMC article.
Highly Cited. Review.
Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex).
Juan F Vera, Lara J Brenner, +8 authors, Cliona M Rooney.
J Immunother, 2010 May 07; 33(3). PMID: 20445351    Free PMC article.
Application of adoptive T-cell therapy using tumor antigen-specific T-cell receptor gene transfer for the treatment of human leukemia.
Toshiki Ochi, Hiroshi Fujiwara, Masaki Yasukawa.
J Biomed Biotechnol, 2010 May 11; 2010. PMID: 20454585    Free PMC article.
Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs.
Takashi Onoe, Hannes Kalscheuer, +3 authors, Megan Sykes.
J Immunol, 2010 May 21; 184(12). PMID: 20483739    Free PMC article.
Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies.
Ami A Shah, Antony Rosen, +2 authors, Livia Casciola-Rosen.
Arthritis Rheum, 2010 May 28; 62(9). PMID: 20506513    Free PMC article.
Immune regulation of cancer.
Mary L Disis.
J Clin Oncol, 2010 Jun 03; 28(29). PMID: 20516428    Free PMC article.
Highly Cited.
Cancer therapy with bispecific antibodies: Clinical experience.
Archana Thakur, Lawrence G Lum.
Curr Opin Mol Ther, 2010 Jun 04; 12(3). PMID: 20521223    Free PMC article.
A vaccine targeting telomerase enhances survival of dogs affected by B-cell lymphoma.
Daniela Peruzzi, Alessandra Gavazza, +7 authors, Luigi Aurisicchio.
Mol Ther, 2010 Jun 10; 18(8). PMID: 20531395    Free PMC article.
Adoptive transfer of unselected or leukemia-reactive T-cells in the treatment of relapse following allogeneic hematopoietic cell transplantation.
Richard J O'Reilly, Tao Dao, +2 authors, Ekaterina Doubrovina.
Semin Immunol, 2010 Jun 12; 22(3). PMID: 20537908    Free PMC article.
Immunotherapy for melanoma: current status and perspectives.
Doru T Alexandrescu, Thomas E Ichim, +4 authors, Constantin A Dasanu.
J Immunother, 2010 Jun 17; 33(6). PMID: 20551839    Free PMC article.
NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies.
Edwin P Alyea, Daniel J DeAngelo, +7 authors, Stan Riddell.
Biol Blood Marrow Transplant, 2010 Jun 29; 16(8). PMID: 20580849    Free PMC article.
Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion.
Stephanie L Goff, Laura A Johnson, +6 authors, Steven A Feldman.
Cancer Immunol Immunother, 2010 Jul 16; 59(10). PMID: 20628878    Free PMC article.
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer.
Rajeev K Shrimali, Zhiya Yu, +3 authors, Steven A Rosenberg.
Cancer Res, 2010 Jul 16; 70(15). PMID: 20631075    Free PMC article.
Highly Cited.
Lymphoma immunotherapy: vaccines, adoptive cell transfer and immunotransplant.
Joshua Brody, Ronald Levy.
Immunotherapy, 2010 Jul 20; 1(5). PMID: 20636025    Free PMC article.
Leisha A Emens.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693839    Free PMC article.
Dendritic cells: are they clinically relevant?
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693842    Free PMC article.
Successful treatment of melanoma brain metastases with adoptive cell therapy.
Jenny J Hong, Steven A Rosenberg, +4 authors, Richard M Sherry.
Clin Cancer Res, 2010 Aug 20; 16(19). PMID: 20719934    Free PMC article.
Analysis of vaccine-induced T cells in humans with cancer.
Stefanie L Slezak, Andrea Worschech, +2 authors, Francesco M Marincola.
Adv Exp Med Biol, 2010 Aug 28; 684. PMID: 20795549    Free PMC article.
IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions.
Cécile Le Saout, Marine Villard, +3 authors, Javier Hernandez.
PLoS One, 2010 Sep 22; 5(9). PMID: 20856822    Free PMC article.
A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors.
Matthew J Goldstein, Bindu Varghese, +5 authors, Ronald Levy.
Blood, 2010 Sep 30; 117(1). PMID: 20876455    Free PMC article.
A pilot study on the immunogenicity of dendritic cell vaccination during adjuvant oxaliplatin/capecitabine chemotherapy in colon cancer patients.
W J Lesterhuis, I J M de Vries, +8 authors, C J A Punt.
Br J Cancer, 2010 Oct 07; 103(9). PMID: 20924373    Free PMC article.
Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes.
Yunyun Su, Edwin K Jackson, Elieser Gorelik.
Cancer Immunol Immunother, 2010 Oct 21; 60(1). PMID: 20960188    Free PMC article.
Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice.
Dhanalakshmi Chinnasamy, Zhiya Yu, +6 authors, Steven A Rosenberg.
J Clin Invest, 2010 Oct 28; 120(11). PMID: 20978347    Free PMC article.
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Ilia N Buhtoiarov, Paul M Sondel, +4 authors, Alexander L Rakhmilevich.
Immunology, 2010 Nov 03; 132(2). PMID: 21039467    Free PMC article.
A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cells.
C Berger, M Berger, D Anderson, S R Riddell.
J Med Primatol, 2010 Nov 04; 40(2). PMID: 21044089    Free PMC article.
Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.
Yolanda Nesbeth, Jose R Conejo-Garcia.
Clin Dev Immunol, 2010 Nov 16; 2010. PMID: 21076522    Free PMC article.
Immunotherapy for ovarian cancer: what's next?
Lana E Kandalaft, Daniel J Powell, Nathan Singh, George Coukos.
J Clin Oncol, 2010 Nov 17; 29(7). PMID: 21079136    Free PMC article.
Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs).
Linh T Nguyen, Pei Hua Yen, +16 authors, Pamela S Ohashi.
PLoS One, 2010 Nov 19; 5(11). PMID: 21085676    Free PMC article.
Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.
Emanuela M Iancu, Petra Baumgaertner, +2 authors, Nathalie Rufer.
J Biomed Biotechnol, 2010 Nov 30; 2011. PMID: 21113290    Free PMC article.
IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells.
Mary Zimmerman, Dafeng Yang, +8 authors, Kebin Liu.
PLoS One, 2010 Dec 03; 5(11). PMID: 21124930    Free PMC article.
Development of human anti-murine T-cell receptor antibodies in both responding and nonresponding patients enrolled in TCR gene therapy trials.
Jeremy L Davis, Marc R Theoret, +3 authors, Richard A Morgan.
Clin Cancer Res, 2010 Dec 09; 16(23). PMID: 21138872    Free PMC article.
Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma.
John H Sampson, Kenneth D Aldape, +15 authors, Amy B Heimberger.
Neuro Oncol, 2010 Dec 15; 13(3). PMID: 21149254    Free PMC article.
Highly Cited.
Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries.
Wolfram Osen, Sabine Soltek, +7 authors, Annette Paschen.
PLoS One, 2010 Dec 15; 5(11). PMID: 21152437    Free PMC article.
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.
Maria R Parkhurst, James C Yang, +16 authors, Steven A Rosenberg.
Mol Ther, 2010 Dec 16; 19(3). PMID: 21157437    Free PMC article.
Highly Cited.
Dendritic cells and immunity against cancer.
K Palucka, H Ueno, J Fay, J Banchereau.
J Intern Med, 2010 Dec 17; 269(1). PMID: 21158979    Free PMC article.
Role of apoptosis resistance in immune evasion and metastasis of colorectal cancer.
Kebin Liu.
World J Gastrointest Oncol, 2010 Dec 17; 2(11). PMID: 21160903    Free PMC article.
Lymphocyte subpopulation and dendritic cell phenotyping during antineoplastic therapy in human solid tumors.
Sara Mariucci, Bianca Rovati, +4 authors, Marco Danova.
Clin Exp Med, 2010 Dec 17; 11(4). PMID: 21161672
Genetic modification of T cells.
Chiara Bonini, Malcolm K Brenner, Helen E Heslop, Richard A Morgan.
Biol Blood Marrow Transplant, 2011 Jan 14; 17(1 Suppl). PMID: 21195304    Free PMC article.
DNA vaccination: using the patient's immune system to overcome cancer.
Georg Eschenburg, Alexander Stermann, +2 authors, Holger N Lode.
Clin Dev Immunol, 2011 Jan 05; 2010. PMID: 21197271    Free PMC article.
A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4(+)FOXP3(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix.
Walayat Shah, Xiaofei Yan, +3 authors, Yili Wang.
Cell Mol Immunol, 2011 Jan 05; 8(1). PMID: 21200385    Free PMC article.
Generation of diffuse large B cell lymphoma-associated antigen-specific Vα6/Vβ13+T cells by TCR gene transfer.
Qingsong Yin, Xianfeng Zha, +4 authors, Yangqiu Li.
J Hematol Oncol, 2011 Jan 13; 4. PMID: 21223579    Free PMC article.
Focus on adoptive T cell transfer trials in melanoma.
Liat Hershkovitz, Jacob Schachter, Avraham J Treves, Michal J Besser.
Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234353    Free PMC article.
Recent developments in cancer vaccines.
Karolina Palucka, Hideki Ueno, Jacques Banchereau.
J Immunol, 2011 Jan 21; 186(3). PMID: 21248270    Free PMC article.
Development of a genetically-modified novel T-cell receptor for adoptive cell transfer against renal cell carcinoma.
Qiong J Wang, Ken-ichi Hanada, +3 authors, James C Yang.
J Immunol Methods, 2011 Jan 25; 366(1-2). PMID: 21255579    Free PMC article.
Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia.
Marie Bleakley, Stanley R Riddell.
Immunol Cell Biol, 2011 Feb 09; 89(3). PMID: 21301477    Free PMC article.
Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice.
Sally M Amos, Hollie J Pegram, +7 authors, Michael H Kershaw.
Cancer Immunol Immunother, 2011 Feb 18; 60(5). PMID: 21327636    Free PMC article.
Timeline: a decade of advances in immunotherapy.
Drew Pardoll.
Nat Med, 2011 Mar 09; 17(3). PMID: 21383743    Free PMC article.
Whole recombinant yeast vaccine induces antitumor immunity and improves survival in a genetically engineered mouse model of melanoma.
A Tanaka, J D Jensen, +6 authors, M Fujita.
Gene Ther, 2011 Mar 11; 18(8). PMID: 21390072    Free PMC article.
Cellular immunotherapy for high-grade glioma.
K H Chow, Stephen Gottschalk.
Immunotherapy, 2011 Mar 15; 3(3). PMID: 21395383    Free PMC article.
Potential clinical applications for human pluripotent stem cell-derived blood components.
Erin A Kimbrel, Shi-Jiang Lu.
Stem Cells Int, 2011 Mar 26; 2011. PMID: 21437192    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Steven A Rosenberg, James C Yang, +12 authors, Mark E Dudley.
Clin Cancer Res, 2011 Apr 19; 17(13). PMID: 21498393    Free PMC article.
Highly Cited.
Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro.
Jianping Huang, Qiong J Wang, +4 authors, Paul F Robbins.
J Immunother, 2011 Apr 19; 34(4). PMID: 21499130    Free PMC article.
Depletion of CD25⁺ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma.
Weiqing Jing, Xiaocai Yan, +2 authors, Bryon D Johnson.
Blood, 2011 Apr 28; 117(25). PMID: 21521781    Free PMC article.
Natural killer cells in human cancer: from biological functions to clinical applications.
Estrella Mariel Levy, María Paula Roberti, José Mordoh.
J Biomed Biotechnol, 2011 May 05; 2011. PMID: 21541191    Free PMC article.
Exploitation of differential homeostatic proliferation of T-cell subsets following chemotherapy to enhance the efficacy of vaccine-mediated antitumor responses.
Sofia R Gameiro, Jorge A Caballero, +2 authors, James W Hodge.
Cancer Immunol Immunother, 2011 May 06; 60(9). PMID: 21544650    Free PMC article.
In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB).
De-Gang Song, Qunrui Ye, +7 authors, Daniel J Powell.
Cancer Res, 2011 May 07; 71(13). PMID: 21546571    Free PMC article.
Highly Cited.
Immune recruitment and therapeutic synergy: keys to optimizing oncolytic viral therapy?
Jay D Naik, Christopher J Twelves, +2 authors, John D Chester.
Clin Cancer Res, 2011 May 18; 17(13). PMID: 21576084    Free PMC article.
Immunomodulatory effects of cyclophosphamide and implementations for vaccine design.
Antonella Sistigu, Sophie Viaud, +3 authors, Laurence Zitvogel.
Semin Immunopathol, 2011 May 26; 33(4). PMID: 21611872
Highly Cited. Review.
Prophylactic cancer vaccination by targeting functional non-self.
Vincent K Tuohy, Ritika Jaini.
Ann Med, 2011 Jun 10; 43(5). PMID: 21651440    Free PMC article.
Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse.
Maciej Kmieciak, Debasmita Basu, +6 authors, Masoud H Manjili.
J Immunol, 2011 Jun 15; 187(2). PMID: 21670315    Free PMC article.
T cells enhance gold nanoparticle delivery to tumors in vivo.
Laura C Kennedy, Adham S Bear, +4 authors, Rebekah A Drezek.
Nanoscale Res Lett, 2011 Jun 30; 6(1). PMID: 21711861    Free PMC article.
Adoptive cell therapy for patients with melanoma.
Mark E Dudley.
J Cancer, 2011 Jul 01; 2. PMID: 21716716    Free PMC article.
Summit on cell therapy for cancer: The importance of the interaction of multiple disciplines to advance clinical therapy.
Cornelis J M Melief, John J O'Shea, David F Stroncek.
J Transl Med, 2011 Jul 12; 9. PMID: 21740581    Free PMC article.
Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
Duane A Mitchell, Xiuyu Cui, +13 authors, John H Sampson.
Blood, 2011 Jul 20; 118(11). PMID: 21768296    Free PMC article.
Characterization of ex vivo expanded tumor infiltrating lymphocytes from patients with malignant melanoma for clinical application.
Niels Junker, Per Thor Straten, Mads Hald Andersen, Inge Marie Svane.
J Skin Cancer, 2011 Jul 21; 2011. PMID: 21773037    Free PMC article.
Cancer immunotherapy--revisited.
W Joost Lesterhuis, John B A G Haanen, Cornelis J A Punt.
Nat Rev Drug Discov, 2011 Aug 02; 10(8). PMID: 21804596
Highly Cited. Review.
Cell transfer immunotherapy for metastatic solid cancer--what clinicians need to know.
Steven A Rosenberg.
Nat Rev Clin Oncol, 2011 Aug 03; 8(10). PMID: 21808266    Free PMC article.
Highly Cited. Review.
Selective expansion and enhanced anti-tumor effect of antigen-specific CD4(+) T cells by retrovirus-mediated IL-15 expression.
Jizhou Lv, Ning Tao, +4 authors, Zhihai Qin.
Protein Cell, 2011 Aug 09; 2(7). PMID: 21822803    Free PMC article.
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes.
Qunrui Ye, Maria Loisiou, +5 authors, Daniel J Powell.
J Transl Med, 2011 Aug 11; 9. PMID: 21827675    Free PMC article.
Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers.
Forrest M Kievit, Miqin Zhang.
Adv Mater, 2011 Aug 16; 23(36). PMID: 21842473    Free PMC article.
Engineered T cells for pancreatic cancer treatment.
Usha L Katari, Jacqueline M Keirnan, +4 authors, Juan F Vera.
HPB (Oxford), 2011 Aug 17; 13(9). PMID: 21843265    Free PMC article.
Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression.
Maria R Parkhurst, John P Riley, Mark E Dudley, Steven A Rosenberg.
Clin Cancer Res, 2011 Aug 17; 17(19). PMID: 21844012    Free PMC article.
Highly Cited.
Biomarkers in T cell therapy clinical trials.
Michael Kalos.
J Transl Med, 2011 Aug 20; 9. PMID: 21851646    Free PMC article.
A prospective study of influenza vaccination and a comparison of immunologic parameters in children and adults with chromosome 22q11.2 deletion syndrome (digeorge syndrome/velocardiofacial syndrome).
Abbas F Jawad, Eline Luning Prak, +4 authors, Kathleen E Sullivan.
J Clin Immunol, 2011 Aug 25; 31(6). PMID: 21863400    Free PMC article.
Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication.
Eugene V Barsov, Matthew T Trivett, +3 authors, David E Ott.
PLoS One, 2011 Sep 03; 6(8). PMID: 21886812    Free PMC article.
IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma.
Li-Li Feng, Jun-Ming Gao, Pei-Pei Li, Xin Wang.
J Clin Immunol, 2011 Sep 08; 31(6). PMID: 21898141
New perspectives on the role of vitiligo in immune responses to melanoma.
Katelyn T Byrne, Mary Jo Turk.
Oncotarget, 2011 Sep 14; 2(9). PMID: 21911918    Free PMC article.
Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer.
Chao-Hsu Li, Wen-Hong Kuo, +3 authors, Bor-Ching Sheu.
Immunol Res, 2011 Sep 16; 51(1). PMID: 21918886
Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes.
Teodora Mocan, Cornel Iancu.
Int J Nanomedicine, 2011 Oct 07; 6. PMID: 21976971    Free PMC article.
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.
Chrystal U Louis, Barbara Savoldo, +14 authors, Malcolm K Brenner.
Blood, 2011 Oct 11; 118(23). PMID: 21984804    Free PMC article.
Highly Cited.
Gammaretroviral vectors: biology, technology and application.
Tobias Maetzig, Melanie Galla, Christopher Baum, Axel Schambach.
Viruses, 2011 Oct 14; 3(6). PMID: 21994751    Free PMC article.
Autoimmune mediated regulation of ovarian tumor growth.
Cengiz Z Altuntas, Ritika Jaini, +7 authors, Vincent K Tuohy.
Gynecol Oncol, 2011 Oct 19; 124(1). PMID: 22004903    Free PMC article.
Science gone translational: the OX40 agonist story.
Andrew D Weinberg, Nicholas P Morris, +2 authors, Brendan D Curti.
Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017441    Free PMC article.
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps.
Padmanee Sharma, Klaus Wagner, Jedd D Wolchok, James P Allison.
Nat Rev Cancer, 2011 Oct 25; 11(11). PMID: 22020206    Free PMC article.
Highly Cited. Review.
Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells.
Seitaro Terakura, Tori N Yamamoto, +3 authors, Stanley R Riddell.
Blood, 2011 Oct 28; 119(1). PMID: 22031866    Free PMC article.
Highly Cited.
GUCY2C-targeted cancer immunotherapy: past, present and future.
Adam E Snook, Michael S Magee, Scott A Waldman.
Immunol Res, 2011 Nov 01; 51(2-3). PMID: 22038530    Free PMC article.
Targeting T cells with bispecific antibodies for cancer therapy.
Lawrence G Lum, Archana Thakur.
BioDrugs, 2011 Nov 05; 25(6). PMID: 22050339    Free PMC article.
Personalized cell transfer immunotherapy for B-cell malignancies and solid cancers.
Steven A Rosenberg, James N Kochenderfer.
Mol Ther, 2011 Nov 05; 19(11). PMID: 22051601    Free PMC article.
Use of allogeneic NK cells for cancer immunotherapy.
Melissa A Geller, Jeffrey S Miller.
Immunotherapy, 2011 Nov 19; 3(12). PMID: 22091681    Free PMC article.
Targeting and utilizing primary tumors as live vaccines: changing strategies.
Xuanming Yang, Eric D Mortenson, Yang-Xin Fu.
Cell Mol Immunol, 2011 Nov 22; 9(1). PMID: 22101245    Free PMC article.
T cells and adoptive immunotherapy: recent developments and future prospects in gastrointestinal oncology.
Amedeo Amedei, Elena Niccolai, Mario M D'Elios.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110523    Free PMC article.
Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells.
Dimitrios N Vatakis, Richard C Koya, +10 authors, Jerome A Zack.
Proc Natl Acad Sci U S A, 2011 Nov 30; 108(51). PMID: 22123951    Free PMC article.
New immune therapy targets tumor-associated environment: from bone marrow to tumor site.
Yang-Xin Fu.
Cell Mol Immunol, 2011 Dec 14; 9(1). PMID: 22157624    Free PMC article.
Genetic engineering with T cell receptors.
Ling Zhang, Richard A Morgan.
Adv Drug Deliv Rev, 2011 Dec 20; 64(8). PMID: 22178904    Free PMC article.
Tumor evasion from T cell surveillance.
Katrin Töpfer, Stefanie Kempe, +5 authors, Achim Temme.
J Biomed Biotechnol, 2011 Dec 23; 2011. PMID: 22190859    Free PMC article.
Cancer immunotherapy comes of age.
Ira Mellman, George Coukos, Glenn Dranoff.
Nature, 2011 Dec 24; 480(7378). PMID: 22193102    Free PMC article.
Highly Cited. Review.
Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy.
Katayoun Rezvani, Agnes S M Yong, +8 authors, A John Barrett.
Cancer Immunol Immunother, 2011 Dec 27; 61(7). PMID: 22198310    Free PMC article.
Characterization of T-cell memory phenotype after in vitro expansion of tumor-infiltrating lymphocytes from melanoma patients.
Juhua Zhou, Prakash Nagarkatti, Yin Zhong, Mitzi Nagarkatti.
Anticancer Res, 2011 Dec 27; 31(12). PMID: 22199267    Free PMC article.
Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells.
Matthew J Goldstein, Holbrook E Kohrt, +4 authors, Ronald Levy.
Cancer Res, 2012 Jan 11; 72(5). PMID: 22232735    Free PMC article.
Novel immunotherapeutic strategies of gastric cancer treatment.
Amedeo Amedei, Marisa Benagiano, +2 authors, Mario M D'Elios.
J Biomed Biotechnol, 2012 Jan 19; 2011. PMID: 22253528    Free PMC article.
Active-specific immunotherapy for non-small cell lung cancer.
Hauke Winter, Natasja K van den Engel, +8 authors, Dominik Rüttinger.
J Thorac Dis, 2012 Jan 21; 3(2). PMID: 22263073    Free PMC article.
CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma.
Peter A Prieto, James C Yang, +6 authors, Giao Q Phan.
Clin Cancer Res, 2012 Jan 25; 18(7). PMID: 22271879    Free PMC article.
Highly Cited.
Adoptive immunotherapy of cancer: Gene transfer of T cell specificity.
Amir A Al-Khami, Shikhar Mehrotra, Michael I Nishimura.
Self Nonself, 2012 Feb 03; 2(2). PMID: 22299059    Free PMC article.
Detection and characterization of a novel subset of CD8⁺CD57⁺ T cells in metastatic melanoma with an incompletely differentiated phenotype.
Richard C Wu, Shujuan Liu, +9 authors, Laszlo G Radvanyi.
Clin Cancer Res, 2012 Feb 07; 18(9). PMID: 22307139    Free PMC article.
Adoptive transfer with high-affinity TCR to treat human solid tumors: how to improve the feasibility?
F Jotereau, N Gervois, N Labarrière.
Target Oncol, 2012 Feb 22; 7(1). PMID: 22350487
The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting.
S Kailayangiri, B Altvater, +12 authors, C Rossig.
Br J Cancer, 2012 Mar 01; 106(6). PMID: 22374462    Free PMC article.
Cytotoxic chemotherapy and CD4+ effector T cells: an emerging alliance for durable antitumor effects.
Zhi-Chun Ding, Gang Zhou.
Clin Dev Immunol, 2012 Mar 09; 2012. PMID: 22400040    Free PMC article.
Spleen cells from young but not old immunized mice eradicate large established cancers.
Karin Schreiber, Ainhoa Arina, +7 authors, Hans Schreiber.
Clin Cancer Res, 2012 Mar 15; 18(9). PMID: 22415314    Free PMC article.
Simplified method of the growth of human tumor infiltrating lymphocytes in gas-permeable flasks to numbers needed for patient treatment.
Jianjian Jin, Marianna Sabatino, +4 authors, Steven A Rosenberg.
J Immunother, 2012 Mar 17; 35(3). PMID: 22421946    Free PMC article.
Cancer immunotherapy via dendritic cells.
Karolina Palucka, Jacques Banchereau.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871    Free PMC article.
Highly Cited. Review.
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells.
John J Engelhardt, Bijan Boldajipour, +5 authors, Matthew F Krummel.
Cancer Cell, 2012 Mar 24; 21(3). PMID: 22439936    Free PMC article.
Highly Cited.
Enhancing cancer immunotherapy by intracellular delivery of cell-penetrating peptides and stimulation of pattern-recognition receptor signaling.
Helen Y Wang, Rong-Fu Wang.
Adv Immunol, 2012 Mar 28; 114. PMID: 22449781    Free PMC article.
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma.
Michael A Postow, James Harding, Jedd D Wolchok.
Cancer J, 2012 Mar 29; 18(2). PMID: 22453017    Free PMC article.
Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook.
Richard Wu, Marie-Andrée Forget, +5 authors, Laszlo G Radvanyi.
Cancer J, 2012 Mar 29; 18(2). PMID: 22453018    Free PMC article.
Raising the bar: the curative potential of human cancer immunotherapy.
Steven A Rosenberg.
Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461638    Free PMC article.
Highly Cited. Review.
Advances in the treatment of metastatic melanoma: adoptive T-cell therapy.
Chantale Bernatchez, Laszlo G Radvanyi, Patrick Hwu.
Semin Oncol, 2012 Apr 10; 39(2). PMID: 22484193    Free PMC article.
Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer.
Akira Yoneda, Shinichiro Ito, +6 authors, Yasuhiro Nagata.
World J Gastroenterol, 2012 Apr 18; 18(13). PMID: 22509078    Free PMC article.
TriVax-HPV: an improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers.
Kelly Barrios, Esteban Celis.
Cancer Immunol Immunother, 2012 Apr 25; 61(8). PMID: 22527249    Free PMC article.
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide.
Mohamed L Salem, Amir A Al-Khami, +4 authors, David J Cole.
Cell Immunol, 2012 May 09; 276(1-2). PMID: 22560674    Free PMC article.
The tipping point for combination therapy: cancer vaccines with radiation, chemotherapy, or targeted small molecule inhibitors.
James W Hodge, Andressa Ardiani, +2 authors, Sofia R Gameiro.
Semin Oncol, 2012 May 19; 39(3). PMID: 22595055    Free PMC article.
Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias.
Ekaterina Doubrovina, Taissia Carpenter, +3 authors, Richard J O'Reilly.
Blood, 2012 May 25; 120(8). PMID: 22623625    Free PMC article.
Two hundred years of cancer research.
Vincent T DeVita, Steven A Rosenberg.
N Engl J Med, 2012 Jun 01; 366(23). PMID: 22646510    Free PMC article.
Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions.
Ivetta Danylesko, Katia Beider, Avichai Shimoni, Arnon Nagler.
Clin Dev Immunol, 2012 Jun 01; 2012. PMID: 22649466    Free PMC article.
Biosensors for immune cell analysis-A perspective.
Alexander Revzin, Emanual Maverakis, H-C Chang.
Biomicrofluidics, 2012 Jun 02; 6(2). PMID: 22655003    Free PMC article.
Generation of natural killer cells from hematopoietic stem cells in vitro for immunotherapy.
Martha Luevano, Alejandro Madrigal, Aurore Saudemont.
Cell Mol Immunol, 2012 Jun 19; 9(4). PMID: 22705914    Free PMC article.
Effective modulation of CD4(+)CD25 (+high) regulatory T and NK cells in malignant patients by combination of interferon-α and interleukin-2.
Guangxian Liu, Wuwei Yang, +17 authors, Bing Liu.
Cancer Immunol Immunother, 2012 Jun 23; 61(12). PMID: 22722448    Free PMC article.
Minimally invasive liver resection to obtain tumor-infiltrating lymphocytes for adoptive cell therapy in patients with metastatic melanoma.
Melissa M Alvarez-Downing, Suzanne M Inchauste, +4 authors, Udai S Kammula.
World J Surg Oncol, 2012 Jun 26; 10. PMID: 22726267    Free PMC article.
Engineering hematopoietic stem cells to create melanoma specific CTL.
Dimitrios Vatakis.
Oncoimmunology, 2012 Jul 04; 1(4). PMID: 22754779    Free PMC article.
A new approach to simultaneously quantify both TCR α- and β-chain diversity after adoptive immunotherapy.
Minying Zhang, Sourindra Maiti, +7 authors, Laurence J N Cooper.
Clin Cancer Res, 2012 Jul 05; 18(17). PMID: 22761473    Free PMC article.
Engineered T cells for anti-cancer therapy.
Cameron J Turtle, Michael Hudecek, Michael C Jensen, Stanley R Riddell.
Curr Opin Immunol, 2012 Jul 24; 24(5). PMID: 22818942    Free PMC article.
Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy.
Zhi-Chun Ding, Lei Huang, +4 authors, Gang Zhou.
Blood, 2012 Aug 04; 120(11). PMID: 22859605    Free PMC article.
Adoptive immunotherapy of advanced melanoma.
Ronnie Shapira-Frommer, Jacob Schachter.
Curr Treat Options Oncol, 2012 Aug 07; 13(3). PMID: 22864561
Sipuleucel-T immune parameters correlate with survival: an analysis of the randomized phase 3 clinical trials in men with castration-resistant prostate cancer.
Nadeem A Sheikh, Daniel Petrylak, +8 authors, David L Urdal.
Cancer Immunol Immunother, 2012 Aug 07; 62(1). PMID: 22865266    Free PMC article.
Highly Cited.
Memory T cells are uniquely resistant to melanoma-induced suppression.
Lucy Wentworth, Justin V Meyers, +3 authors, Clifford S Cho.
Cancer Immunol Immunother, 2012 Aug 07; 62(1). PMID: 22865267    Free PMC article.
Nine lives for TH9s?
Weiping Zou, Nicholas P Restifo.
Nat Med, 2012 Aug 08; 18(8). PMID: 22869182    Free PMC article.
STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma.
Lutfun Naher, Tamotsu Kiyoshima, +7 authors, Hidetaka Sakai.
Int J Oncol, 2012 Aug 28; 41(5). PMID: 22922995    Free PMC article.
Lessons from cancer immunoediting in cutaneous melanoma.
Mariana Aris, María Marcela Barrio, José Mordoh.
Clin Dev Immunol, 2012 Aug 28; 2012. PMID: 22924051    Free PMC article.
PD-1 and BTLA and CD8(+) T-cell "exhaustion" in cancer: "Exercising" an alternative viewpoint.
Cara Haymaker, Richard Wu, Chantale Bernatchez, Laszlo Radvanyi.
Oncoimmunology, 2012 Aug 31; 1(5). PMID: 22934265    Free PMC article.
Improving T cell responses to modified peptides in tumor vaccines.
Jonathan D Buhrman, Jill E Slansky.
Immunol Res, 2012 Sep 01; 55(1-3). PMID: 22936035    Free PMC article.
Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells.
Yoo Jin Choi, Kwang Mo Yang, +7 authors, Wol Soon Jo.
Exp Ther Med, 2012 Sep 13; 3(4). PMID: 22969934    Free PMC article.
Augmentation of anti-tumor immunity by adoptive T-cell transfer after allogeneic hematopoietic stem cell transplantation.
Marie Bleakley, Cameron J Turtle, Stanley R Riddell.
Expert Rev Hematol, 2012 Sep 21; 5(4). PMID: 22992235    Free PMC article.
Isolation of human MHC class II-restricted T cell receptors from the autologous T-cell repertoire with potent anti-leukaemic reactivity.
Luise U Weigand, Xiaoling Liang, +8 authors, Angela M Krackhardt.
Immunology, 2012 Oct 03; 137(3). PMID: 23025755    Free PMC article.
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients.
Laszlo G Radvanyi, Chantale Bernatchez, +32 authors, Patrick Hwu.
Clin Cancer Res, 2012 Oct 04; 18(24). PMID: 23032743    Free PMC article.
Highly Cited.
Cancer vaccines and T cell therapy.
Katayoun Rezvani, Joshua D Brody, +9 authors, John Barrett.
Biol Blood Marrow Transplant, 2012 Oct 09; 19(1 Suppl). PMID: 23041602    Free PMC article.
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.
Jennifer Landsberg, Judith Kohlmeyer, +8 authors, Thomas Tüting.
Nature, 2012 Oct 12; 490(7420). PMID: 23051752
Highly Cited.
Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma.
Qiong J Wang, Ken-Ichi Hanada, +2 authors, James C Yang.
Cancer Res, 2012 Oct 17; 72(23). PMID: 23071066    Free PMC article.
The past, present, and future of adoptive T cell therapy.
Donghoon Choi, Tai-Gyu Kim, Young Chul Sung.
Immune Netw, 2012 Oct 24; 12(4). PMID: 23091437    Free PMC article.
Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy.
Gheath Alatrash, Elizabeth A Mittendorf, +21 authors, Jeffrey J Molldrem.
J Immunol, 2012 Oct 30; 189(11). PMID: 23105141    Free PMC article.
Anti-tumor immunity: myeloid leukocytes control the immune landscape.
Melanie R Rutkowski, Tom L Stephen, Jose R Conejo-Garcia.
Cell Immunol, 2012 Nov 06; 278(1-2). PMID: 23121972    Free PMC article.
Impact of temozolomide on immune response during malignant glioma chemotherapy.
Sadhak Sengupta, Jaclyn Marrinan, Caroline Frishman, Prakash Sampath.
Clin Dev Immunol, 2012 Nov 08; 2012. PMID: 23133490    Free PMC article.
Dynamic tracing of immune cells in an orthotopic gastric carcinoma mouse model using near-infrared fluorescence live imaging.
Xiaohui DU, Xiangyu Wang, +5 authors, Yingxin Xu.
Exp Ther Med, 2012 Nov 10; 4(2). PMID: 23139711    Free PMC article.
Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response.
Hao-Li Liu, Han-Yi Hsieh, +3 authors, Chun-Yen Lin.
J Transl Med, 2012 Nov 13; 10. PMID: 23140567    Free PMC article.
Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma.
Serena K Perna, Biagio De Angelis, +8 authors, Barbara Savoldo.
Clin Cancer Res, 2012 Nov 15; 19(1). PMID: 23149818    Free PMC article.
A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs).
Jennifer D Stone, David H Aggen, +2 authors, David M Kranz.
Oncoimmunology, 2012 Nov 20; 1(6). PMID: 23162754    Free PMC article.
Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas.
Adriana Cordova, Francesca Toia, +11 authors, Francesco Moschella.
PLoS One, 2012 Nov 29; 7(11). PMID: 23189169    Free PMC article.
High-avidity T cells are preferentially tolerized in the tumor microenvironment.
Ziqiang Zhu, Vinod Singh, +4 authors, Arthur A Hurwitz.
Cancer Res, 2012 Dec 04; 73(2). PMID: 23204239    Free PMC article.
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
Jing Ni, Matthias Miller, +2 authors, Adelheid Cerwenka.
J Exp Med, 2012 Dec 05; 209(13). PMID: 23209317    Free PMC article.
Highly Cited.
Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies.
Carlos A Ramos, Neeharika Narala, +8 authors, Cliona M Rooney.
J Immunother, 2012 Dec 06; 36(1). PMID: 23211628    Free PMC article.
The role of B7 family molecules in hematologic malignancy.
Paul Greaves, John G Gribben.
Blood, 2012 Dec 12; 121(5). PMID: 23223433    Free PMC article.
Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.
Bryan D Choi, Chien-Tsun Kuan, +7 authors, John H Sampson.
Proc Natl Acad Sci U S A, 2012 Dec 19; 110(1). PMID: 23248284    Free PMC article.
Antigen loss and tumor-mediated immunosuppression facilitate tumor recurrence.
Brian M Olson, Douglas G McNeel.
Expert Rev Vaccines, 2012 Dec 20; 11(11). PMID: 23249231    Free PMC article.
Immunotherapy of malignant disease using chimeric antigen receptor engrafted T cells.
John Maher.
ISRN Oncol, 2013 Jan 11; 2012. PMID: 23304553    Free PMC article.
Engineered drug resistant γδ T cells kill glioblastoma cell lines during a chemotherapy challenge: a strategy for combining chemo- and immunotherapy.
Lawrence S Lamb, Joscelyn Bowersock, +4 authors, H Trent Spencer.
PLoS One, 2013 Jan 18; 8(1). PMID: 23326319    Free PMC article.
CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network.
Alexandre Boissonnas, Fabrice Licata, +6 authors, Christophe Combadière.
Neoplasia, 2013 Jan 30; 15(1). PMID: 23359264    Free PMC article.
Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.
Danushka K Wijesundara, David C Tscharke, Ronald J Jackson, Charani Ranasinghe.
PLoS One, 2013 Feb 06; 8(1). PMID: 23383283    Free PMC article.
Chemoimmunotherapy: reengineering tumor immunity.
Gang Chen, Leisha A Emens.
Cancer Immunol Immunother, 2013 Feb 08; 62(2). PMID: 23389507    Free PMC article.
Tumor-induced endothelial cell surface heterogeneity directly affects endothelial cell escape from a cell-mediated immune response in vitro.
Petr G Lokhov, Elena E Balashova.
Hum Vaccin Immunother, 2013 Feb 28; 9(1). PMID: 23442592    Free PMC article.
Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression.
Dimitrios N Vatakis, Balamurugan Arumugam, +3 authors, Jerome A Zack.
Mol Ther, 2013 Mar 14; 21(5). PMID: 23481324    Free PMC article.
Development of allogeneic NK cell adoptive transfer therapy in metastatic melanoma patients: in vitro preclinical optimization studies.
Michal J Besser, Tsipi Shoham, +7 authors, Gal Markel.
PLoS One, 2013 Mar 14; 8(3). PMID: 23483943    Free PMC article.
Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases.
Jian Zhong Qin, Vivek Upadhyay, Bellur Prabhakar, Ajay V Maker.
J Transl Med, 2013 Mar 22; 11. PMID: 23514280    Free PMC article.
Immune correlates of melanoma survival in adoptive cell therapy.
Agnes Fermin Lee, Peter A Sieling, Delphine J Lee.
Oncoimmunology, 2013 Mar 26; 2(2). PMID: 23525606    Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.
Mark J Dobrzanski.
Front Oncol, 2013 Mar 28; 3. PMID: 23533029    Free PMC article.
Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?
Michael Hölzel, Anton Bovier, Thomas Tüting.
Nat Rev Cancer, 2013 Mar 29; 13(5). PMID: 23535846
Highly Cited. Review.
Tumor-immune dynamics regulated in the microenvironment inform the transient nature of immune-induced tumor dormancy.
Kathleen P Wilkie, Philip Hahnfeldt.
Cancer Res, 2013 Mar 29; 73(12). PMID: 23536560    Free PMC article.
Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.
Jessica Ann Chacon, Richard C Wu, +6 authors, Laszlo Radvanyi.
PLoS One, 2013 Apr 06; 8(4). PMID: 23560068    Free PMC article.
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy.
Shi Zhong, Karolina Malecek, +12 authors, Michelle Krogsgaard.
Proc Natl Acad Sci U S A, 2013 Apr 12; 110(17). PMID: 23576742    Free PMC article.
Highly Cited.
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.
Tyce J Kearl, Weiqing Jing, Jill A Gershan, Bryon D Johnson.
J Immunol, 2013 Apr 26; 190(11). PMID: 23616570    Free PMC article.
Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.
Dhanalakshmi Chinnasamy, Eric Tran, +3 authors, Steven A Rosenberg.
Cancer Res, 2013 May 02; 73(11). PMID: 23633494    Free PMC article.
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.
Paul F Robbins, Yong-Chen Lu, +9 authors, Steven A Rosenberg.
Nat Med, 2013 May 07; 19(6). PMID: 23644516    Free PMC article.
Highly Cited.
Optimal management of metastatic melanoma: current strategies and future directions.
Marta Batus, Salman Waheed, +3 authors, Howard L Kaufman.
Am J Clin Dermatol, 2013 May 17; 14(3). PMID: 23677693    Free PMC article.
Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.
Yong-Chen Lu, Xin Yao, +8 authors, Paul F Robbins.
J Immunol, 2013 May 22; 190(12). PMID: 23690473    Free PMC article.
Colorectal cancer immunotherapy.
Bo Xiang, Adam E Snook, Michael S Magee, Scott A Waldman.
Discov Med, 2013 Jun 04; 15(84). PMID: 23725603    Free PMC article.
An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma.
David A Reardon, Kai W Wucherpfennig, +8 authors, Glenn Dranoff.
Expert Rev Vaccines, 2013 Jun 12; 12(6). PMID: 23750791    Free PMC article.
What are the molecules involved in regulatory T-cells induction by dendritic cells in cancer?
Rodrigo Nalio Ramos, Cristiano Jacob de Moraes, Bruna Zelante, José Alexandre M Barbuto.
Clin Dev Immunol, 2013 Jun 14; 2013. PMID: 23762097    Free PMC article.
TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer.
Magdalena Nauerth, Bianca Weißbrich, +14 authors, Dirk H Busch.
Sci Transl Med, 2013 Jul 05; 5(192). PMID: 23825303    Free PMC article.
Optimizing the immune system to achieve control of the metastatic malignant lesion.
Myron Arlen, Philip Arlen.
J Cancer, 2013 Jul 09; 4(5). PMID: 23833687    Free PMC article.
Antibody, T-cell and dendritic cell immunotherapy for malignant brain tumors.
Vidyalakshmi Chandramohan, Duane A Mitchell, +2 authors, Darell D Bigner.
Future Oncol, 2013 Jul 11; 9(7). PMID: 23837761    Free PMC article.
Nanoengineering approaches to the design of artificial antigen-presenting cells.
Joel C Sunshine, Jordan J Green.
Nanomedicine (Lond), 2013 Jul 11; 8(7). PMID: 23837856    Free PMC article.
Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging.
L Liebsch, S Kailayangiri, +10 authors, C Rossig.
Br J Cancer, 2013 Jul 11; 109(3). PMID: 23839490    Free PMC article.
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology.
Michael Kalos, Carl H June.
Immunity, 2013 Jul 31; 39(1). PMID: 23890063    Free PMC article.
Highly Cited. Review.
Deciphering and reversing tumor immune suppression.
Greg T Motz, George Coukos.
Immunity, 2013 Jul 31; 39(1). PMID: 23890064    Free PMC article.
Highly Cited. Review.
Safety and efficacy of a genetic vaccine targeting telomerase plus chemotherapy for the therapy of canine B-cell lymphoma.
Alessandra Gavazza, George Lubas, +7 authors, Luigi Aurisicchio.
Hum Gene Ther, 2013 Aug 02; 24(8). PMID: 23902422    Free PMC article.
Potential limitations of the NSG humanized mouse as a model system to optimize engineered human T cell therapy for cancer.
Erik M Alcantar-Orozco, Hannah Gornall, +2 authors, David E Gilham.
Hum Gene Ther Methods, 2013 Aug 13; 24(5). PMID: 23931270    Free PMC article.
Death receptor-independent activation-induced cell death in human melanoma antigen-specific MHC class I-restricted TCR-engineered CD4 T cells.
Arvind Chhabra, Bijay Mukherji.
J Immunol, 2013 Aug 13; 191(6). PMID: 23935194    Free PMC article.
Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma.
Meenakshi Hegde, Amanda Corder, +16 authors, Nabil Ahmed.
Mol Ther, 2013 Aug 14; 21(11). PMID: 23939024    Free PMC article.
Highly Cited.
Expression of leukotriene B₄ receptor-1 on CD8⁺ T cells is required for their migration into tumors to elicit effective antitumor immunity.
Rajesh Kumar Sharma, Zinal Chheda, Venkatakrishna Rao Jala, Bodduluri Haribabu.
J Immunol, 2013 Aug 21; 191(6). PMID: 23960231    Free PMC article.
Simplified process for the production of anti-CD19-CAR-engineered T cells.
Barbara Tumaini, Daniel W Lee, +5 authors, Marianna Sabatino.
Cytotherapy, 2013 Sep 03; 15(11). PMID: 23992830    Free PMC article.
Immunotherapy strategies for multiple myeloma: the present and the future.
Frederick L Locke, Taiga Nishihori, Melissa Alsina, Mohamed A Kharfan-Dabaja.
Immunotherapy, 2013 Sep 04; 5(9). PMID: 23998734    Free PMC article.
Melanoma-associated leukoderma - immunology in black and white?
Hadas Prag Naveh, Uma N M Rao, Lisa H Butterfield.
Pigment Cell Melanoma Res, 2013 Sep 10; 26(6). PMID: 24010963    Free PMC article.
CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor.
Qunrui Ye, De-Gang Song, +5 authors, Daniel J Powell.
Clin Cancer Res, 2013 Sep 21; 20(1). PMID: 24045181    Free PMC article.
Highly Cited.
Impact of T cell selection methods in the success of clinical adoptive immunotherapy.
Natalia Ramírez, Lorea Beloki, +5 authors, Eduardo Olavarría.
Cell Mol Life Sci, 2013 Oct 01; 71(7). PMID: 24077876
Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells.
Sarah E Church, Shawn M Jensen, +2 authors, Bernard A Fox.
Eur J Immunol, 2013 Oct 12; 44(1). PMID: 24114780    Free PMC article.
High-throughput identification of antigen-specific TCRs by TCR gene capture.
Carsten Linnemann, Bianca Heemskerk, +25 authors, Ton N M Schumacher.
Nat Med, 2013 Oct 15; 19(11). PMID: 24121928
CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2.
D Bedognetti, T L Spivey, +13 authors, F M Marincola.
Br J Cancer, 2013 Oct 17; 109(9). PMID: 24129241    Free PMC article.
T-cell engager-armed oncolytic vaccinia virus significantly enhances antitumor therapy.
Feng Yu, Xingbing Wang, +3 authors, Xiao-Tong Song.
Mol Ther, 2013 Oct 19; 22(1). PMID: 24135899    Free PMC article.
Natural killer T cells in advanced melanoma patients treated with tremelimumab.
F Javier Ibarrondo, Otto O Yang, +11 authors, Begoña Comin-Anduix.
PLoS One, 2013 Oct 30; 8(10). PMID: 24167550    Free PMC article.
The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.
Gunnar Hedlund, Helena Eriksson, +6 authors, Per Björk.
PLoS One, 2013 Nov 07; 8(10). PMID: 24194959    Free PMC article.
Immune suppression in tumors as a surmountable obstacle to clinical efficacy of cancer vaccines.
Grégoire Wieërs, Nathalie Demotte, Danièle Godelaine, Pierre Van der Bruggen.
Cancers (Basel), 2011 Jan 01; 3(3). PMID: 24212939    Free PMC article.
Tumor-associated antigens for specific immunotherapy of prostate cancer.
Andrea Kiessling, Rebekka Wehner, +3 authors, Marc Schmitz.
Cancers (Basel), 2012 Jan 01; 4(1). PMID: 24213236    Free PMC article.
Tumor lysate-loaded biodegradable microparticles as cancer vaccines.
Vijaya B Joshi, Sean M Geary, +3 authors, Aliasger K Salem.
Expert Rev Vaccines, 2013 Nov 14; 13(1). PMID: 24219096    Free PMC article.
CD271 on melanoma cell is an IFN-γ-inducible immunosuppressive factor that mediates downregulation of melanoma antigens.
Junpei Furuta, Takashi Inozume, Kazutoshi Harada, Shinji Shimada.
J Invest Dermatol, 2013 Nov 15; 134(5). PMID: 24226422
Engineered T cells for cancer treatment.
Usanarat Anurathapan, Ann M Leen, Malcolm K Brenner, Juan F Vera.
Cytotherapy, 2013 Nov 19; 16(6). PMID: 24239105    Free PMC article.
Chimeric antigen receptor therapy for cancer.
David M Barrett, Nathan Singh, +2 authors, Carl H June.
Annu Rev Med, 2013 Nov 28; 65. PMID: 24274181    Free PMC article.
Highly Cited. Review.
New approaches to manipulate minimal residual disease after allogeneic stem cell transplantation.
Lindsay Am Rein, Anthony D Sung, David A Rizzieri.
Int J Hematol Oncol, 2013 Dec 05; 2(1). PMID: 24303095    Free PMC article.
Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells.
Michael C Jensen, Stanley R Riddell.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329794    Free PMC article.
Re-adapting T cells for cancer therapy: from mouse models to clinical trials.
Ingunn M Stromnes, Thomas M Schmitt, +2 authors, Philip D Greenberg.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329795    Free PMC article.
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.
John H Sampson, Bryan D Choi, +12 authors, Laura A Johnson.
Clin Cancer Res, 2013 Dec 20; 20(4). PMID: 24352643    Free PMC article.
Highly Cited.
T cell avidity and tumor immunity: problems and solutions.
Arthur A Hurwitz, Steven M Cuss, Katherine E Stagliano, Ziqiang Zhu.
Cancer Microenviron, 2013 Dec 21; 7(1-2). PMID: 24357332    Free PMC article.
A patient-specific therapeutic approach for tumour cell population extinction and drug toxicity reduction using control systems-based dose-profile design.
Suhela Kapoor, V P Subramanyam Rallabandi, +2 authors, Prasun K Roy.
Theor Biol Med Model, 2013 Dec 29; 10. PMID: 24369857    Free PMC article.
Immunotherapy for colorectal cancer.
Shigeo Koido, Toshifumi Ohkusa, +12 authors, Hisao Tajiri.
World J Gastroenterol, 2014 Jan 01; 19(46). PMID: 24379570    Free PMC article.
Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 T-cell responses against established tumors.
Toshihiro Nagato, Young-Ran Lee, Yasuaki Harabuchi, Esteban Celis.
Clin Cancer Res, 2014 Jan 07; 20(5). PMID: 24389326    Free PMC article.
Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor.
Ge Zhang, Lei Wang, +10 authors, Bin Gao.
Sci Rep, 2014 Jan 07; 4. PMID: 24389689    Free PMC article.
Adoptive immunotherapy for cancer or viruses.
Marcela V Maus, Joseph A Fraietta, +3 authors, Carl H June.
Annu Rev Immunol, 2014 Jan 16; 32. PMID: 24423116    Free PMC article.
Highly Cited. Review.
Editorial on "heat shock protein peptide complex-96 (HSPPC-96) vaccination for recurrent glioblastoma: a phase II, single arm trial".
John H Sampson, Gordana Vlahovic.
Neuro Oncol, 2014 Jan 21; 16(2). PMID: 24443362    Free PMC article.
Genetically modified T cells for the treatment of malignant disease.
Agnieszka Wieczorek, Lutz Uharek.
Transfus Med Hemother, 2014 Jan 30; 40(6). PMID: 24474888    Free PMC article.
Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer.
Takeshi Ishikawa, Satoshi Kokura, +16 authors, Toshikazu Yoshikawa.
PLoS One, 2014 Feb 06; 9(1). PMID: 24497917    Free PMC article.
Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion.
Kathleen P Wilkie, Philip Hahnfeldt.
Interface Focus, 2014 Feb 11; 3(4). PMID: 24511375    Free PMC article.
Immunotherapy in gastric cancer.
Satoko Matsueda, David Y Graham.
World J Gastroenterol, 2014 Mar 04; 20(7). PMID: 24587645    Free PMC article.
Clinical utility of natural killer cells in cancer therapy and transplantation.
David A Knorr, Veronika Bachanova, Michael R Verneris, Jeffrey S Miller.
Semin Immunol, 2014 Mar 13; 26(2). PMID: 24618042    Free PMC article.
Highly Cited. Review.
Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma.
Thinle Chodon, Begoña Comin-Anduix, +31 authors, Antoni Ribas.
Clin Cancer Res, 2014 Mar 19; 20(9). PMID: 24634374    Free PMC article.
Highly Cited.
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.
Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641    Free PMC article.
Highly Cited.
Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging.
Michelle Farazi, Justine Nguyen, +4 authors, Carl E Ruby.
Cancer Immunol Immunother, 2014 Apr 01; 63(6). PMID: 24682539    Free PMC article.
Shaping the repertoire of tumor-infiltrating effector and regulatory T cells.
Peter A Savage, Daniel S Leventhal, Sven Malchow.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712470    Free PMC article.
How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
Ole Audun Werner Haabeth, Anders Aune Tveita, +8 authors, Bjarne Bogen.
Front Immunol, 2014 May 02; 5. PMID: 24782871    Free PMC article.
Highly Cited. Review.
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Gregory T Motz, Stephen P Santoro, +7 authors, George Coukos.
Nat Med, 2014 May 06; 20(6). PMID: 24793239    Free PMC article.
Highly Cited.
Primer on tumor immunology and cancer immunotherapy.
Timothy J Harris, Charles G Drake.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829749    Free PMC article.
Induced pluripotent stem cells: challenges and opportunities for cancer immunotherapy.
Patty Sachamitr, Simon Hackett, Paul Jonathan Fairchild.
Front Immunol, 2014 May 27; 5. PMID: 24860566    Free PMC article.
Tumor immunology and cancer immunotherapy: summary of the 2013 SITC primer.
Raju R Raval, Andrew B Sharabi, +2 authors, Padmanee Sharma.
J Immunother Cancer, 2014 Jun 03; 2. PMID: 24883190    Free PMC article.
IL-2: the first effective immunotherapy for human cancer.
Steven A Rosenberg.
J Immunol, 2014 Jun 08; 192(12). PMID: 24907378    Free PMC article.
Highly Cited. Review.
Stromal reengineering to treat pancreas cancer.
Ingunn M Stromnes, Kathleen E DelGiorno, Philip D Greenberg, Sunil R Hingorani.
Carcinogenesis, 2014 Jun 09; 35(7). PMID: 24908682    Free PMC article.
Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.
Laïla-Aïcha Hanafi, Dominique Gauchat, +5 authors, Réjean Lapointe.
PLoS One, 2014 Jun 10; 9(6). PMID: 24911872    Free PMC article.
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.
Frédérique Végran, Hélène Berger, +11 authors, Lionel Apetoh.
Nat Immunol, 2014 Jun 30; 15(8). PMID: 24973819
Highly Cited.
Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.
Yong-Chen Lu, Xin Yao, +9 authors, Paul F Robbins.
Clin Cancer Res, 2014 Jul 06; 20(13). PMID: 24987109    Free PMC article.
Highly Cited.
Generation of thyroid follicular cells from pluripotent stem cells: potential for regenerative medicine.
Will Sewell, Reigh-Yi Lin.
Front Endocrinol (Lausanne), 2014 Jul 06; 5. PMID: 24995001    Free PMC article.
A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy.
Dong-Sup Chung, Hye-Jin Shin, Yong-Kil Hong.
J Immunol Res, 2014 Jul 11; 2014. PMID: 25009822    Free PMC article.
The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells.
Dominique N Lisiero, Horacio Soto, +2 authors, Robert M Prins.
J Immunother Cancer, 2014 Jul 24; 2. PMID: 25054063    Free PMC article.
Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice.
Sudipto Ganguly, Duncan B Ross, +4 authors, Leo Luznik.
Blood, 2014 Aug 21; 124(13). PMID: 25139358    Free PMC article.
Standard of care and future pharmacological treatment options for malignant glioma: an urgent need for screening and identification of novel tumor-specific antigens.
Kristen A Batich, John H Sampson.
Expert Opin Pharmacother, 2014 Aug 21; 15(14). PMID: 25139628    Free PMC article.
Molecular imaging in tracking tumor-specific cytotoxic T lymphocytes (CTLs).
Zhiyi Liu, Zheng Li.
Theranostics, 2014 Aug 27; 4(10). PMID: 25157278    Free PMC article.
AACR Cancer Progress Report 2014.
Carlos L Arteaga, Peter C Adamson, +11 authors, George J Weiner.
Clin Cancer Res, 2014 Sep 18; 20(19 Suppl). PMID: 25228531    Free PMC article.
Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects.
Huan Shi, Meili Sun, Lin Liu, Zhehai Wang.
Mol Cancer, 2014 Sep 23; 13. PMID: 25241075    Free PMC article.
Modeling cancer-immune responses to therapy.
L G dePillis, A Eladdadi, A E Radunskaya.
J Pharmacokinet Pharmacodyn, 2014 Oct 05; 41(5). PMID: 25281420
Reprogramming immune responses via microRNA modulation.
Juan R Cubillos-Ruiz, Melanie R Rutkowski, Julia Tchou, Jose R Conejo-Garcia.
Microrna Diagn Ther, 2013 Apr 26; 1(1). PMID: 25285232    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Intratumoral checkpoint subversion as a strategy for minimizing adverse effects: Harvesting the power of TILs without harvesting TILs.
Leah Alabanza, Sacha Gnjatic, Nina Bhardwaj, Joshua Brody.
Oncoimmunology, 2014 Oct 24; 3. PMID: 25339995    Free PMC article.
Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors.
Eugene M Cozza, Timothy K Cooper, +2 authors, Todd D Schell.
Cancer Immunol Immunother, 2014 Nov 20; 64(3). PMID: 25408469    Free PMC article.
Persistence of CTL clones targeting melanocyte differentiation antigens was insufficient to mediate significant melanoma regression in humans.
Smita S Chandran, Biman C Paria, +9 authors, Udai S Kammula.
Clin Cancer Res, 2014 Nov 27; 21(3). PMID: 25424856    Free PMC article.
Cancer Immunotherapy Using γδT Cells: Dealing with Diversity.
Wouter Scheper, Zsolt Sebestyen, Jürgen Kuball.
Front Immunol, 2014 Dec 06; 5. PMID: 25477886    Free PMC article.
To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy.
Jessica E Thaxton, Zihai Li.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483644    Free PMC article.
Improving the safety of cell therapy products by suicide gene transfer.
Benjamin S Jones, Lawrence S Lamb, Frederick Goldman, Antonio Di Stasi.
Front Pharmacol, 2014 Dec 17; 5. PMID: 25505885    Free PMC article.
The delicate balance of melanoma immunotherapy.
David E Gyorki, Margaret Callahan, Jedd D Wolchok, Charlotte E Ariyan.
Clin Transl Immunology, 2013 Aug 01; 2(8). PMID: 25505953    Free PMC article.
Adoptive T-cell therapy: adverse events and safety switches.
Siok-Keen Tey.
Clin Transl Immunology, 2014 Dec 17; 3(6). PMID: 25505965    Free PMC article.
Current advances in T-cell-based cancer immunotherapy.
Mingjun Wang, Bingnan Yin, Helen Y Wang, Rong-Fu Wang.
Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524383    Free PMC article.
Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.
Xiaoyun Lu, Zhi-Chun Ding, +8 authors, Gang Zhou.
J Immunol, 2015 Jan 07; 194(4). PMID: 25560408    Free PMC article.
Invariant natural killer T cells generated from human adult hematopoietic stem-progenitor cells are poly-functional.
Wenji Sun, Yi Wang, +5 authors, Tonya J Webb.
Cytokine, 2015 Jan 09; 72(1). PMID: 25569376    Free PMC article.
Potential for immunotherapy in soft tissue sarcoma.
William W Tseng, Neeta Somaiah, Edgar G Engleman.
Hum Vaccin Immunother, 2015 Jan 28; 10(11). PMID: 25625925    Free PMC article.
The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients.
Michelle Paff, Daniela Alexandru-Abrams, Frank P K Hsu, Daniela A Bota.
Hum Vaccin Immunother, 2015 Jan 28; 10(11). PMID: 25625931    Free PMC article.
Mouse model for pre-clinical study of human cancer immunotherapy.
Zhiya Ya, Yared Hailemichael, Willem Overwijk, Nicholas P Restifo.
Curr Protoc Immunol, 2015 Feb 03; 108. PMID: 25640991    Free PMC article.
Rindopepimut: anti-EGFRvIII peptide vaccine, oncolytic.
Patrick C Gedeon, Bryan D Choi, John H Sampson, Darell D Bigner.
Drugs Future, 2013 Mar 01; 38(3). PMID: 25663738    Free PMC article.
Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma.
Ling Zhang, Richard A Morgan, +15 authors, Steven A Rosenberg.
Clin Cancer Res, 2015 Feb 20; 21(10). PMID: 25695689    Free PMC article.
Highly Cited.
Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.
Ivan Liadi, Harjeet Singh, +9 authors, Navin Varadarajan.
Cancer Immunol Res, 2015 Feb 26; 3(5). PMID: 25711538    Free PMC article.
Design of universal cancer vaccines using natural tumor vessel-specific antigens (SANTAVAC).
Petr G Lokhov, Elena E Balashova.
Hum Vaccin Immunother, 2015 Feb 26; 11(3). PMID: 25714389    Free PMC article.
Manufacture of tumor- and virus-specific T lymphocytes for adoptive cell therapies.
X Wang, I Rivière.
Cancer Gene Ther, 2015 Feb 28; 22(2). PMID: 25721207    Free PMC article.
Immunotherapy for malignant glioma.
Carter M Suryadevara, Terence Verla, +4 authors, John H Sampson.
Surg Neurol Int, 2015 Feb 28; 6(Suppl 1). PMID: 25722935    Free PMC article.
Innate memory T cells.
Stephen C Jameson, You Jeong Lee, Kristin A Hogquist.
Adv Immunol, 2015 Mar 03; 126. PMID: 25727290    Free PMC article.
Immunoprofiling for prognostic assessment of colon cancer: a novel complement to ultrastaging.
Simon Lavotshkin, John R Jalas, +8 authors, Anton J Bilchik.
J Gastrointest Surg, 2015 Mar 27; 19(6). PMID: 25808375    Free PMC article.
Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.
Melissa N McCracken, Dimitrios N Vatakis, +3 authors, Owen N Witte.
J Clin Invest, 2015 Mar 31; 125(5). PMID: 25822024    Free PMC article.
Impact of the immune system and immunotherapy in colorectal cancer.
Janet L Markman, Stephen L Shiao.
J Gastrointest Oncol, 2015 Apr 02; 6(2). PMID: 25830040    Free PMC article.
Modular Three-component Delivery System Facilitates HLA Class I Antigen Presentation and CD8(+) T-cell Activation Against Tumors.
Benjamin J Umlauf, Chin-Ying Chung, Kathlynn C Brown.
Mol Ther, 2015 Apr 15; 23(6). PMID: 25868400    Free PMC article.
Tumor infiltrating lymphocytes in ovarian cancer.
Phillip P Santoiemma, Daniel J Powell.
Cancer Biol Ther, 2015 Apr 22; 16(6). PMID: 25894333    Free PMC article.
Highly Cited. Review.
Toxicities of Immunotherapy for the Practitioner.
Jeffrey S Weber, James C Yang, Michael B Atkins, Mary L Disis.
J Clin Oncol, 2015 Apr 29; 33(18). PMID: 25918278    Free PMC article.
Highly Cited. Review.
Adoptive T Regulatory Cell Therapy for Tolerance Induction.
Cecilia Cabello-Kindelan, Shane Mackey, Allison L Bayer.
Curr Transplant Rep, 2015 May 06; 2(2). PMID: 25938011    Free PMC article.
Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.
Joal D Beane, Gary Lee, +20 authors, Steven A Feldman.
Mol Ther, 2015 May 06; 23(8). PMID: 25939491    Free PMC article.
Gastric cancer and the epoch of immunotherapy approaches.
Elena Niccolai, Antonio Taddei, Domenico Prisco, Amedeo Amedei.
World J Gastroenterol, 2015 May 29; 21(19). PMID: 26019442    Free PMC article.
CD8(+) T cell response to adenovirus vaccination and subsequent suppression of tumor growth: modeling, simulation and analysis.
Qing Wang, David J Klinke, Zhijun Wang.
BMC Syst Biol, 2015 Jun 07; 9. PMID: 26048402    Free PMC article.
Cellular therapy in combination with cytokines improves survival in a xenograft mouse model of ovarian cancer.
Susan B Ingersoll, Sarfraz Ahmad, +7 authors, Robert W Holloway.
Mol Cell Biochem, 2015 Jun 07; 407(1-2). PMID: 26048718
A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy.
Julien Valton, Valérie Guyot, +5 authors, Laurent Poirot.
Mol Ther, 2015 Jun 11; 23(9). PMID: 26061646    Free PMC article.
iCaspase 9 Suicide Gene System.
Xiaoou Zhou, Antonio Di Stasi, Malcolm K Brenner.
Methods Mol Biol, 2015 Jun 15; 1317. PMID: 26072403    Free PMC article.
Systemic LPS Translocation Activates Cross-Presenting Dendritic Cells but Is Dispensable for the Breakdown of CD8+ T Cell Peripheral Tolerance in Irradiated Mice.
Gabriel Espinosa-Carrasco, Marine Villard, +3 authors, Javier Hernandez.
PLoS One, 2015 Jun 16; 10(6). PMID: 26075613    Free PMC article.
Tumor-Specific Effector CD8+ T Cells That Can Establish Immunological Memory in Humans after Adoptive Transfer Are Marked by Expression of IL7 Receptor and c-myc.
Smita S Chandran, Biman C Paria, +3 authors, Udai S Kammula.
Cancer Res, 2015 Jun 24; 75(16). PMID: 26100671    Free PMC article.
Harnessing the Microbiome to Enhance Cancer Immunotherapy.
Michelle H Nelson, Marshall A Diven, Logan W Huff, Chrystal M Paulos.
J Immunol Res, 2015 Jun 24; 2015. PMID: 26101781    Free PMC article.
Are BiTEs the "missing link" in cancer therapy?
Carter M Suryadevara, Patrick C Gedeon, +5 authors, John H Sampson.
Oncoimmunology, 2015 Jul 15; 4(6). PMID: 26155413    Free PMC article.
In vitro and in vivo antitumor effects of 50 to 100-KDa components from B16 melanoma culture supernatant.
Ying-Song Qin, X U Zhang, Xiang-Yu Zhang.
Oncol Lett, 2015 Jul 15; 10(1). PMID: 26170991    Free PMC article.
Generation of CD8(+) T cells expressing two additional T-cell receptors (TETARs) for personalised melanoma therapy.
Sandra Höfflin, Sabrina Prommersberger, +5 authors, Niels Schaft.
Cancer Biol Ther, 2015 Jul 17; 16(9). PMID: 26178065    Free PMC article.
Immunotherapy of melanoma.
John B A G Haanen.
EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217118    Free PMC article.
Prospects of immune checkpoint modulators in the treatment of glioblastoma.
Matthias Preusser, Michael Lim, +2 authors, John H Sampson.
Nat Rev Neurol, 2015 Aug 12; 11(9). PMID: 26260659    Free PMC article.
Highly Cited. Review.
CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity.
G Elizabeth Pluhar, Christopher A Pennell, Michael R Olin.
Crit Rev Immunol, 2015 Sep 10; 35(2). PMID: 26351148    Free PMC article.
Immune Reactivation by Cell-Free Fetal DNA in Healthy Pregnancies Re-Purposed to Target Tumors: Novel Checkpoint Inhibition in Cancer Therapeutics.
Elizabeth Ann L Enninga, Wendy K Nevala, Shernan G Holtan, Svetomir N Markovic.
Front Immunol, 2015 Sep 18; 6. PMID: 26379664    Free PMC article.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Kyle A Wilson, Stephen R Goding, +2 authors, Paul Andrew Antony.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570    Free PMC article.
Biomaterial Strategies for Immunomodulation.
Nathan A Hotaling, Li Tang, Darrell J Irvine, Julia E Babensee.
Annu Rev Biomed Eng, 2015 Oct 01; 17. PMID: 26421896    Free PMC article.
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Junko Matsuzaki, Takemasa Tsuji, +7 authors, Kunle Odunsi.
Sci Rep, 2015 Oct 09; 5. PMID: 26447332    Free PMC article.
Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia.
Hanren Dai, Wenying Zhang, +14 authors, Weidong Han.
Oncoimmunology, 2015 Oct 10; 4(11). PMID: 26451310    Free PMC article.
Highly Cited.
Characterization of T cell repertoire of blood, tumor, and ascites in ovarian cancer patients using next generation sequencing.
Miran Jang, Poh-Yin Yew, +5 authors, Jae-Hyun Park.
Oncoimmunology, 2015 Oct 10; 4(11). PMID: 26451311    Free PMC article.
Boosting humoral and cellular immunity to pneumococcus by vaccination before and just after autologous transplant for myeloma.
F L Locke, M Menges, +3 authors, C Anasetti.
Bone Marrow Transplant, 2015 Oct 13; 51(2). PMID: 26457911    Free PMC article.
Gene therapy returns to centre stage.
Luigi Naldini.
Nature, 2015 Oct 16; 526(7573). PMID: 26469046
Highly Cited. Review.
Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies.
Simon Gebremeskel, Brent Johnston.
Oncotarget, 2015 Oct 22; 6(39). PMID: 26486085    Free PMC article.
T-cell receptor gene therapy--ready to go viral?
Terhi Karpanen, Johanna Olweus.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533    Free PMC article.
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy.
Payal Mittal, Marie-Clare St Rose, +4 authors, Adam J Adler.
J Immunol, 2015 Nov 13; 195(12). PMID: 26561553    Free PMC article.
Tumor-infiltrating lymphocytes for the treatment of metastatic cancer.
M H Geukes Foppen, M Donia, I M Svane, J B A G Haanen.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578452    Free PMC article.
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy.
Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong.
J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545    Free PMC article.
Toxicities Associated With Adoptive T-Cell Transfer for Cancer.
James C Yang.
Cancer J, 2015 Nov 21; 21(6). PMID: 26588684    Free PMC article.
Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II.
Cagri Sakalar, Suparna Mazumder, +6 authors, Vincent K Tuohy.
J Immunol Res, 2015 Dec 01; 2015. PMID: 26618181    Free PMC article.
Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014.
Paolo A Ascierto, Michael Atkins, +34 authors, Magdalena Thurin.
J Transl Med, 2015 Dec 02; 13. PMID: 26619946    Free PMC article.
Suppression of established hepatocarcinoma in adjuvant only immunotherapy: alum triggers anti-tumor CD8+ T cell response.
Bo Wang, Xuanyi Wang, +5 authors, Bin Wang.
Sci Rep, 2015 Dec 10; 5. PMID: 26647964    Free PMC article.
Genetic Immunization With In Vivo Dendritic Cell-targeting Liposomal DNA Vaccine Carrier Induces Long-lasting Antitumor Immune Response.
Arup Garu, Gopikrishna Moku, Suresh Kumar Gulla, Arabinda Chaudhuri.
Mol Ther, 2015 Dec 17; 24(2). PMID: 26666450    Free PMC article.
CCR 20th Anniversary Commentary: Autologous T Cells-The Ultimate Personalized Drug for the Immunotherapy of Human Cancer.
Steven A Rosenberg.
Clin Cancer Res, 2015 Dec 17; 21(24). PMID: 26672082    Free PMC article.
Cord Blood as a Source of Natural Killer Cells.
Rohtesh S Mehta, Elizabeth J Shpall, Katayoun Rezvani.
Front Med (Lausanne), 2016 Jan 19; 2. PMID: 26779484    Free PMC article.
Anti-ovarian tumor response of donor peripheral blood mononuclear cells is due to infiltrating cytotoxic NK cells.
Veethika Pandey, Jeremiah L Oyer, +3 authors, Deborah A Altomare.
Oncotarget, 2016 Jan 24; 7(6). PMID: 26802025    Free PMC article.
Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice.
Zheng Hu, Jinxing Xia, +2 authors, Yong-Guang Yang.
Oncotarget, 2016 Jan 30; 7(6). PMID: 26824989    Free PMC article.
Cross-platform comparison of independent datasets identifies an immune signature associated with improved survival in metastatic melanoma.
Ricardo D Lardone, Seema B Plaisier, +4 authors, Delphine J Lee.
Oncotarget, 2016 Feb 18; 7(12). PMID: 26883106    Free PMC article.
Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning.
Michelle H Nelson, Jacob S Bowers, +7 authors, Chrystal M Paulos.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885368    Free PMC article.
Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma.
Katherine Woods, Ashley J Knights, +4 authors, Jonathan Cebon.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885372    Free PMC article.
Expression analysis and association of RBBP6 with apoptosis in colon cancers.
Zodwa Dlamini, Charleen Rupnarain, +2 authors, Zukile Mbita.
J Mol Histol, 2016 Feb 26; 47(2). PMID: 26905308
Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome.
Francesca Toia, Simona Buccheri, +4 authors, Adriana Cordova.
PLoS One, 2016 Feb 26; 11(2). PMID: 26915072    Free PMC article.
Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells.
Kyle K Payne, Rebecca C Keim, +6 authors, Masoud H Manjili.
J Leukoc Biol, 2016 Mar 02; 100(3). PMID: 26928306    Free PMC article.
Role of memory T cell subsets for adoptive immunotherapy.
Dirk H Busch, Simon P Fräßle, +2 authors, Stanley R Riddell.
Semin Immunol, 2016 Mar 16; 28(1). PMID: 26976826    Free PMC article.
Highly Cited. Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Mathematical Modelling and Analysis of the Tumor Treatment Regimens with Pulsed Immunotherapy and Chemotherapy.
Liuyong Pang, Lin Shen, Zhong Zhao.
Comput Math Methods Med, 2016 Mar 22; 2016. PMID: 26997972    Free PMC article.
Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects.
Yelei Guo, Yao Wang, Weidong Han.
J Immunol Res, 2016 Mar 22; 2016. PMID: 26998495    Free PMC article.
The beneficial effects of a gas-permeable flask for expansion of Tumor-Infiltrating lymphocytes as reflected in their mitochondrial function and respiration capacity.
Marie-Andrée Forget, Cara Haymaker, +7 authors, Chantale Bernatchez.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057427    Free PMC article.
Marrow-Infiltrating Lymphocytes - Role in Biology and Cancer Therapy.
Ivan Borrello, Kimberly A Noonan.
Front Immunol, 2016 Apr 12; 7. PMID: 27066005    Free PMC article.
Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells.
Ann Ager, H Angharad Watson, Sophie C Wehenkel, Rebar N Mohammed.
Biochem Soc Trans, 2016 Apr 14; 44(2). PMID: 27068943    Free PMC article.
Safety of targeting tumor endothelial cell antigens.
Samuel C Wagner, Neil H Riordan, +8 authors, Santosh Kesari.
J Transl Med, 2016 Apr 14; 14. PMID: 27071457    Free PMC article.
Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor.
Agnes Shuk-Yee Lo, Chen Xu, Akikazu Murakami, Wayne A Marasco.
Mol Ther Oncolytics, 2014 Jan 01; 1. PMID: 27119093    Free PMC article.
Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3' untranslated region of TRIT1.
Rolf K Swoboda, Rajasekharan Somasundaram, +4 authors, Dorothee Herlyn.
Mol Ther Oncolytics, 2015 Jan 01; 1. PMID: 27119099    Free PMC article.
CD19xCD3 DART protein mediates human B-cell depletion in vivo in humanized BLT mice.
Perry Tsai, William O Thayer, +3 authors, J Victor Garcia.
Mol Ther Oncolytics, 2016 Apr 28; 3. PMID: 27119115    Free PMC article.
Planes, Trains, and Automobiles: Perspectives on CAR T Cells and Other Cellular Therapies for Hematologic Malignancies.
Saar Gill.
Curr Hematol Malig Rep, 2016 May 04; 11(4). PMID: 27136938    Free PMC article.
Strategies to genetically engineer T cells for cancer immunotherapy.
Timothy T Spear, Kaoru Nagato, Michael I Nishimura.
Cancer Immunol Immunother, 2016 May 04; 65(6). PMID: 27138532    Free PMC article.
IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?
Jakub Tomala, Marek Kovar.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141363    Free PMC article.
Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona, Eleftherios P Diamandis, Ivan M Blasutig.
BMC Med, 2016 May 07; 14. PMID: 27151159    Free PMC article.
Highly Cited. Review.
Decay Dynamics of Tumors.
Álvaro G López, Jesús M Seoane, Miguel A F Sanjuán.
PLoS One, 2016 Jun 17; 11(6). PMID: 27310010    Free PMC article.
Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune Response.
John Reiser, Arnob Banerjee.
J Immunol Res, 2016 Jun 18; 2016. PMID: 27314056    Free PMC article.
Modeling Human Leukemia Immunotherapy in Humanized Mice.
Jinxing Xia, Zheng Hu, +7 authors, Yong-Guang Yang.
EBioMedicine, 2016 Jul 11; 10. PMID: 27394641    Free PMC article.
A Perspective of Immunotherapy for Prostate Cancer.
Ida Silvestri, Susanna Cattarino, +3 authors, Alessandro Sciarra.
Cancers (Basel), 2016 Jul 12; 8(7). PMID: 27399780    Free PMC article.
Central Nervous System: (Immunological) Ivory Tower or Not?
Ioana A Marin, Jonathan Kipnis.
Neuropsychopharmacology, 2016 Jul 13; 42(1). PMID: 27402496    Free PMC article.
Recent advances and future of immunotherapy for glioblastoma.
Neha Kamran, Alexandra Calinescu, +7 authors, Maria G Castro.
Expert Opin Biol Ther, 2016 Jul 14; 16(10). PMID: 27411023    Free PMC article.
Metastatic melanoma and immunotherapy.
Benjamin Herzberg, David E Fisher.
Clin Immunol, 2016 Jul 20; 172. PMID: 27430520    Free PMC article.
IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells.
Zhi-Chun Ding, Chufeng Liu, +10 authors, Gang Zhou.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471650    Free PMC article.
Cancer testis antigen and immunotherapy.
Deepa Kolaseri Krishnadas, Fanqi Bai, Kenneth G Lucas.
Immunotargets Ther, 2013 Jan 01; 2. PMID: 27471684    Free PMC article.
CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas.
Katherine A Murphy, Thomas S Griffith.
Cancers (Basel), 2016 Jul 30; 8(8). PMID: 27472363    Free PMC article.
Improving the safety of T-Cell therapies using an inducible caspase-9 gene.
Xiaoou Zhou, Malcolm K Brenner.
Exp Hematol, 2016 Oct 27; 44(11). PMID: 27473568    Free PMC article.
Current status of engineered T-cell therapy for synovial sarcoma.
Matthew Dallos, William D Tap, Sandra P D'Angelo.
Immunotherapy, 2016 Aug 04; 8(9). PMID: 27485079    Free PMC article.
Chemotherapy and immunotherapy: A close interplay to fight cancer?
Aurélie Hanoteau, Muriel Moser.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622046    Free PMC article.
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Tamsin Dockree, Christopher J Holland, +12 authors, Linda Wooldridge.
Immunol Cell Biol, 2016 Sep 28; 95(1). PMID: 27670790    Free PMC article.
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization.
Melissa Frick, Pierre Mouchacca, +7 authors, Claude Boyer.
Immunology, 2016 Nov 03; 150(2). PMID: 27716898    Free PMC article.
In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by 19F-Fluorine MRS/MRI.
Christine Gonzales, Hikari A I Yoshihara, +6 authors, Juerg Schwitter.
PLoS One, 2016 Oct 14; 11(10). PMID: 27736925    Free PMC article.
Generation of T cell effectors using tumor cell-loaded dendritic cells for adoptive T cell therapy.
Katerina Vavrova, Petra Vrabcova, +2 authors, Rudolf Horvath.
Med Oncol, 2016 Nov 05; 33(12). PMID: 27812850
Intraperitoneal immunotherapy: historical perspectives and modern therapy.
W F Morano, A Aggarwal, +3 authors, W B Bowne.
Cancer Gene Ther, 2016 Nov 12; 23(11). PMID: 27834358
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity.
Michael S Magee, Crystal L Kraft, +5 authors, Adam E Snook.
Oncoimmunology, 2016 Nov 18; 5(10). PMID: 27853651    Free PMC article.
Conditional control of suicide gene expression in tumor cells with theophylline-responsive ribozyme.
Y Zhang, J Wang, +4 authors, R Pei.
Gene Ther, 2016 Nov 23; 24(2). PMID: 27874855
SANTAVAC ™: A Novel Universal Antigen Composition for Developing Cancer Vaccines.
Petr G Lokhov, Elena E Balashova.
Recent Pat Biotechnol, 2016 Dec 03; 11(1). PMID: 27903220    Free PMC article.
Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer.
Michel van Gelder, Ariane Vanclée, +3 authors, Gerard M Bos.
Breast Cancer Res Treat, 2016 Dec 05; 161(3). PMID: 27915436    Free PMC article.
Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.
Latha B Pathangey, Dustin B McCurry, +7 authors, Peter A Cohen.
Oncotarget, 2016 Dec 16; 8(7). PMID: 27974697    Free PMC article.
Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion.
Sinnie Sin Man Ng, Bethany A Nagy, +6 authors, George N Pavlakis.
Clin Cancer Res, 2016 Dec 18; 23(11). PMID: 27986749    Free PMC article.
PD-L1 Expression and Combined Status of PD-L1/PD-1-Positive Tumor Infiltrating Mononuclear Cell Density Predict Prognosis in Glioblastoma Patients.
Jiheun Han, Yongkil Hong, Youn Soo Lee.
J Pathol Transl Med, 2016 Dec 19; 51(1). PMID: 27989100    Free PMC article.
Immuno-Oncology: The Third Paradigm in Early Drug Development.
Juan Martin-Liberal, Cinta Hierro, Maria Ochoa de Olza, Jordi Rodon.
Target Oncol, 2016 Dec 21; 12(2). PMID: 27995439
Driving gene-engineered T cell immunotherapy of cancer.
Laura A Johnson, Carl H June.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025979    Free PMC article.
Highly Cited. Review.
Immune targets and neoantigens for cancer immunotherapy and precision medicine.
Rong-Fu Wang, Helen Y Wang.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025978    Free PMC article.
Highly Cited. Review.
Low preoperative prognostic nutritional index predicts poor survival in patients with newly diagnosed high-grade gliomas.
Zhen-Qiang He, Chao Ke, +10 authors, Yong-Gao Mou.
J Neurooncol, 2017 Jan 13; 132(2). PMID: 28078639
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
T-cell receptor-engineered T cells for cancer treatment: current status and future directions.
Yu Ping, Chaojun Liu, Yi Zhang.
Protein Cell, 2017 Jan 22; 9(3). PMID: 28108950    Free PMC article.
Highly Cited. Review.
It's a long way to the top (if you want to personalize immunotherapy).
Sarah Haebe, Oliver Weigert.
J Immunother Cancer, 2017 Jan 25; 5. PMID: 28116089    Free PMC article.
IL-15 enhances the antitumor effect of human antigen-specific CD8+ T cells by cellular senescence delay.
Jinsheng Weng, Kelsey E Moriarty, +12 authors, Larry W Kwak.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123872    Free PMC article.
Applications of Immunogenomics to Cancer.
X Shirley Liu, Elaine R Mardis.
Cell, 2017 Feb 12; 168(4). PMID: 28187283    Free PMC article.
Highly Cited. Review.
Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening.
Matthias Schröder, Simone Loos, +5 authors, Lee Kim Swee.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197378    Free PMC article.
Immune modulation by dendritic-cell-based cancer vaccines.
Chaitanya Kumar, Sakshi Kohli, +4 authors, Bandana Sharan.
J Biosci, 2017 Feb 24; 42(1). PMID: 28229976
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.
Kristen M Hege, Emily K Bergsland, +7 authors, Stephen A Sherwin.
J Immunother Cancer, 2017 Mar 28; 5. PMID: 28344808    Free PMC article.
Highly Cited.
Tumor-infiltrating lymphocytes (TILs) from patients with glioma.
Zhenjiang Liu, Qingda Meng, +11 authors, Markus Maeurer.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344863    Free PMC article.
CAR T-cell therapy for pancreatic cancer.
Carl J DeSelm, Zachary E Tano, Anna M Varghese, Prasad S Adusumilli.
J Surg Oncol, 2017 Mar 28; 116(1). PMID: 28346697    Free PMC article.
High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations.
Amélie Boichard, Igor F Tsigelny, Razelle Kurzrock.
Oncoimmunology, 2017 Apr 14; 6(3). PMID: 28405512    Free PMC article.
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.
Kristen A Batich, Elizabeth A Reap, +14 authors, John H Sampson.
Clin Cancer Res, 2017 Apr 16; 23(8). PMID: 28411277    Free PMC article.
Highly Cited.
Low absolute peripheral blood CD4+ T-cell count predicts poor prognosis in R-CHOP-treated patients with diffuse large B-cell lymphoma.
Y Kusano, M Yokoyama, +9 authors, K Hatake.
Blood Cancer J, 2017 Apr 22; 7(4). PMID: 28430176    Free PMC article.
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Stefani Spranger, Daisy Dai, Brendan Horton, Thomas F Gajewski.
Cancer Cell, 2017 May 10; 31(5). PMID: 28486109    Free PMC article.
Highly Cited.
CAR T-cell therapy for lung cancer and malignant pleural mesothelioma.
Masha Zeltsman, Jordan Dozier, +2 authors, Prasad S Adusumilli.
Transl Res, 2017 May 16; 187. PMID: 28502785    Free PMC article.
SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.
Jungsun Park, Amjad H Talukder, +17 authors, Cassian Yee.
Cancer Immunol Res, 2017 Jun 21; 5(8). PMID: 28630054    Free PMC article.
Prognostic and predictive factors in patients with metastatic or recurrent cervical cancer treated with platinum-based chemotherapy.
Sofia Karageorgopoulou, Ioannis D Kostakis, +5 authors, Christos A Papadimitriou.
BMC Cancer, 2017 Jul 01; 17(1). PMID: 28659181    Free PMC article.
Cancer Immunotherapy, Part 2: Efficacy, Safety, and Other Clinical Considerations.
C Lee Ventola.
P T, 2017 Jul 05; 42(7). PMID: 28674473    Free PMC article.
Cancer Immunotherapies: Are They as Effective in the Elderly?
Kate Poropatich, Joel Fontanarosa, +2 authors, Bin Zhang.
Drugs Aging, 2017 Jul 15; 34(8). PMID: 28707274
Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers.
Kaichao Feng, Yang Liu, +6 authors, Weidong Han.
Protein Cell, 2017 Jul 16; 9(10). PMID: 28710747    Free PMC article.
Immunotherapeutic Strategies for Gastric Carcinoma: A Review of Preclinical and Clinical Recent Development.
Mohamed Abozeid, Antonio Rosato, Roberta Sommaggio.
Biomed Res Int, 2017 Aug 07; 2017. PMID: 28781967    Free PMC article.
Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3.
Yong-Chen Lu, Linda L Parker, +14 authors, Steven A Rosenberg.
J Clin Oncol, 2017 Aug 16; 35(29). PMID: 28809608    Free PMC article.
Highly Cited.
RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.
Dennis C Harrer, Bianca Simon, +7 authors, Niels Schaft.
BMC Cancer, 2017 Aug 19; 17(1). PMID: 28818060    Free PMC article.
Immunotherapy in Gynecologic Cancers: Are We There Yet?
Janelle B Pakish, Amir A Jazaeri.
Curr Treat Options Oncol, 2017 Aug 26; 18(10). PMID: 28840453    Free PMC article.
Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM).
Astero Klampatsa, Andrew R Haas, Edmund K Moon, Steven M Albelda.
Cancers (Basel), 2017 Sep 02; 9(9). PMID: 28862644    Free PMC article.
Inherent Immunogenicity or Lack Thereof of Pluripotent Stem Cells: Implications for Cell Replacement Therapy.
Arvind Chhabra.
Front Immunol, 2017 Sep 05; 8. PMID: 28868053    Free PMC article.
Tumor-related interleukins: old validated targets for new anti-cancer drug development.
Sarra Setrerrahmane, Hanmei Xu.
Mol Cancer, 2017 Sep 21; 16(1). PMID: 28927416    Free PMC article.
PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8+ T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination.
Arash Memarnejadian, Courtney E Meilleur, +4 authors, S M Mansour Haeryfar.
J Immunol, 2017 Sep 25; 199(9). PMID: 28939757    Free PMC article.
Chemokines as adjuvants for immunotherapy: implications for immune activation with CCL3.
Teilo H Schaller, Kristen A Batich, +2 authors, John H Sampson.
Expert Rev Clin Immunol, 2017 Oct 03; 13(11). PMID: 28965431    Free PMC article.
Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression.
Ariella Glasner, Batya Isaacson, +6 authors, Ofer Mandelboim.
Sci Rep, 2017 Oct 14; 7(1). PMID: 29026144    Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth.
Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Norman Woller.
Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503    Free PMC article.
Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy.
Dinler A Antunes, Maurício M Rigo, +7 authors, Gustavo F Vieira.
Front Immunol, 2017 Oct 20; 8. PMID: 29046675    Free PMC article.
Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation.
Sivan Seliktar-Ofir, Efrat Merhavi-Shoham, +4 authors, Michal J Besser.
Front Immunol, 2017 Oct 27; 8. PMID: 29067023    Free PMC article.
Trial Watch: Adoptively transferred cells for anticancer immunotherapy.
Carole Fournier, François Martin, +3 authors, Lionel Apetoh.
Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147628    Free PMC article.
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
Yohsuke Yagawa, Mark Robertson-Tessi, +3 authors, Adam W Mailloux.
Sci Rep, 2017 Nov 24; 7(1). PMID: 29167448    Free PMC article.
Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology.
Joseph G Crompton, Nicholas Klemen, Udai S Kammula.
Ann Surg Oncol, 2017 Dec 01; 25(2). PMID: 29188500    Free PMC article.
Immune checkpoint inhibitors for advanced non-small cell lung cancer: emerging sequencing for new treatment targets.
Pedro Nazareth Aguiar, Ramon Andrade De Mello, +4 authors, Gilberto de Lima Lopes.
ESMO Open, 2017 Dec 07; 2(3). PMID: 29209522    Free PMC article.
Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.
Mohsen Ibrahim, Davide Scozzi, +9 authors, Andrew E Gelman.
J Immunol, 2017 Dec 08; 200(2). PMID: 29212908    Free PMC article.
Drug development in the era of precision medicine.
Sarah A Dugger, Adam Platt, David B Goldstein.
Nat Rev Drug Discov, 2017 Dec 09; 17(3). PMID: 29217837    Free PMC article.
Highly Cited. Review.
Towards personalized, tumour-specific, therapeutic vaccines for cancer.
Zhuting Hu, Patrick A Ott, Catherine J Wu.
Nat Rev Immunol, 2017 Dec 12; 18(3). PMID: 29226910    Free PMC article.
Highly Cited. Review.
Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research.
Helena Kupcova Skalnikova, Jana Cizkova, Jakub Cervenka, Petr Vodicka.
Int J Mol Sci, 2017 Dec 14; 18(12). PMID: 29236046    Free PMC article.
Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions.
Hsiu-Chuan Wei, Jui-Ling Yu, Chia-Yu Hsu.
Comput Math Methods Med, 2017 Dec 19; 2017. PMID: 29250133    Free PMC article.
Informatics for cancer immunotherapy.
J Hammerbacher, A Snyder.
Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253114    Free PMC article.
Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
Sonia Guedan, Avery D Posey, +14 authors, Carl H June.
JCI Insight, 2018 Jan 13; 3(1). PMID: 29321369    Free PMC article.
Highly Cited.
Immunotherapy of cancer: targeting cancer during active disease or during dormancy?
Syed Ammer Shah, Melika Zarei, +3 authors, Masoud H Manjili.
Immunotherapy, 2018 Jan 18; 9(11). PMID: 29338608    Free PMC article.
Radiation effects on antitumor immune responses: current perspectives and challenges.
Thomas Walle, Rafael Martinez Monge, +3 authors, Fernando Lecanda.
Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383033    Free PMC article.
Highly Cited. Review.
Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy.
Aurélie Durgeau, Yasemin Virk, Stéphanie Corgnac, Fathia Mami-Chouaib.
Front Immunol, 2018 Feb 07; 9. PMID: 29403496    Free PMC article.
Highly Cited. Review.
IL-2 and Beyond in Cancer Immunotherapy.
John M Wrangle, Alicia Patterson, +7 authors, Mark P Rubinstein.
J Interferon Cytokine Res, 2018 Feb 15; 38(2). PMID: 29443657    Free PMC article.
Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.
Mireia Uribe-Herranz, Kyle Bittinger, +10 authors, Andrea Facciabene.
JCI Insight, 2018 Feb 23; 3(4). PMID: 29467322    Free PMC article.
An Altered Ratio of CD4+ And CD8+ T Lymphocytes in Cervical Cancer Tissues and Peripheral Blood – A Prognostic Clue?
Diptimoy Das, Basab Sarkar, +2 authors, Supreeti Biswas Mondal.
Asian Pac J Cancer Prev, 2018 Feb 27; 19(2). PMID: 29480666    Free PMC article.
Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells.
Taigo Kato, Tatsuo Matsuda, +10 authors, Yusuke Nakamura.
Oncotarget, 2018 Mar 16; 9(13). PMID: 29541393    Free PMC article.
Survivin-Based Treatment Strategies for Squamous Cell Carcinoma.
Andrea Santarelli, Marco Mascitti, +4 authors, Lorenzo Lo Muzio.
Int J Mol Sci, 2018 Mar 29; 19(4). PMID: 29587347    Free PMC article.
Rapid Construction of Antitumor T-cell Receptor Vectors from Frozen Tumors for Engineered T-cell Therapy.
Takemasa Tsuji, Akira Yoneda, +4 authors, Kunle Odunsi.
Cancer Immunol Res, 2018 Mar 29; 6(5). PMID: 29588318    Free PMC article.
Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8+ T Cells.
C Bryce Johnson, Bennett R May, +10 authors, Mark P Rubinstein.
Cancer Res, 2018 Apr 11; 78(11). PMID: 29636345    Free PMC article.
Artificial Antigen Presenting Cells: An Off the Shelf Approach for Generation of Desirable T-Cell Populations for Broad Application of Adoptive Immunotherapy.
A N Hasan, A Selvakumar, R J O'Reilly.
Adv Genet Eng, 2015 Jan 01; 4(3). PMID: 29644163    Free PMC article.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673    Free PMC article.
A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma.
Patrick C Gedeon, Teilo H Schaller, +16 authors, John H Sampson.
Clin Cancer Res, 2018 Apr 29; 24(15). PMID: 29703821    Free PMC article.
Strategies for enhancing adoptive T-cell immunotherapy against solid tumors using engineered cytokine signaling and other modalities.
Thomas Shum, Robert L Kruse, Cliona M Rooney.
Expert Opin Biol Ther, 2018 May 05; 18(6). PMID: 29727246    Free PMC article.
Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes in Advanced Melanoma Patients.
Mélanie Saint-Jean, Anne-Chantal Knol, +10 authors, Brigitte Dréno.
J Immunol Res, 2018 May 12; 2018. PMID: 29750176    Free PMC article.
Adoptive cell transfer using autologous tumor infiltrating lymphocytes in gynecologic malignancies.
Paul Mayor, Kristen Starbuck, Emese Zsiros.
Gynecol Oncol, 2018 May 29; 150(2). PMID: 29803316    Free PMC article.
Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome.
Marie-Andrée Forget, Cara Haymaker, +44 authors, Chantale Bernatchez.
Clin Cancer Res, 2018 Jun 01; 24(18). PMID: 29848573    Free PMC article.
Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies.
Shangjun Sun, He Hao, +2 authors, Yang Fu.
J Immunol Res, 2018 Jun 01; 2018. PMID: 29850622    Free PMC article.
Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma.
Carter M Suryadevara, Rupen Desai, +14 authors, Luis Sanchez-Perez.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872570    Free PMC article.
CD133-directed CAR T cells for advanced metastasis malignancies: A phase I trial.
Yao Wang, Meixia Chen, +11 authors, Weidong Han.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900044    Free PMC article.
Highly Cited.
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.
Thomas Duhen, Rebekka Duhen, +12 authors, Andrew D Weinberg.
Nat Commun, 2018 Jul 15; 9(1). PMID: 30006565    Free PMC article.
Highly Cited.
Dendritic cells cross-talk with tumour antigen-specific CD8+ T cells, Vγ9γδT cells and Vα24NKT cells in patients with glioblastoma multiforme and in healthy donors.
Y Eiraku, H Terunuma, +3 authors, M Nieda.
Clin Exp Immunol, 2018 Jul 17; 194(1). PMID: 30009488    Free PMC article.
The promise and challenges of chimeric antigen receptor T cells in relapsed B-cell acute lymphoblastic leukemia.
Zhi-Chun Ding.
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Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics.
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CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
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The current status of immunotherapy for cervical cancer.
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Front Immunol, 2018 Dec 14; 9. PMID: 30546367    Free PMC article.
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JCI Insight, 2019 Jul 25; 5. PMID: 31335326    Free PMC article.
Investigating Macrophages Plasticity Following Tumour-Immune Interactions During Oncolytic Therapies.
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Front Immunol, 2019 Nov 05; 10. PMID: 31681338    Free PMC article.
CAR T Cells: A Snapshot on the Growing Options to Design a CAR.
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Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts.
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J Transl Med, 2020 Feb 07; 18(1). PMID: 32024530    Free PMC article.
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Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.
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Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?
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Emerging Role and Future Directions of Immunotherapy in Advanced Ovarian Cancer.
Thinle Chodon, Amit A Lugade, Sebastiano Battaglia, Kunle Odunsi.
Hematol Oncol Clin North Am, 2018 Nov 06; 32(6). PMID: 30390758    Free PMC article.
Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer.
Dristhi Ragoonanan, Sajad J Khazal, +39 authors, Kris M Mahadeo.
Nat Rev Clin Oncol, 2021 Feb 21; 18(7). PMID: 33608690
Reactive myelopoiesis and the onset of myeloid-mediated immune suppression: Implications for adoptive cell therapy.
Patrick Innamarato, Shari Pilon-Thomas.
Cell Immunol, 2021 Jan 22; 361. PMID: 33476931    Free PMC article.
Synthetic TILs: Engineered Tumor-Infiltrating Lymphocytes With Improved Therapeutic Potential.
Anaïs Jiménez-Reinoso, Daniel Nehme-Álvarez, Carmen Domínguez-Alonso, Luis Álvarez-Vallina.
Front Oncol, 2021 Mar 09; 10. PMID: 33680923    Free PMC article.
Tumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokine.
Seung E Cha, Maciej Kujawski, +2 authors, John E Shively.
Oncoimmunology, 2021 Apr 03; 10(1). PMID: 33796409    Free PMC article.
Systemic Therapy of Metastatic Melanoma: On the Road to Cure.
Julian Steininger, Frank Friedrich Gellrich, +3 authors, Friedegund Meier.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33804800    Free PMC article.
Realizing Innate Potential: CAR-NK Cell Therapies for Acute Myeloid Leukemia.
Mark Gurney, Michael O'Dwyer.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33805422    Free PMC article.
Immuno-oncology: a narrative review of gastrointestinal and hepatic toxicities.
Stergios Boussios, Matin Sheriff, +7 authors, Nicholas Pavlidis.
Ann Transl Med, 2021 Apr 13; 9(5). PMID: 33842644    Free PMC article.
Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response.
Venkataswarup Tiriveedhi, Michael T Ivy, +3 authors, Jens Titze.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33918403    Free PMC article.
Expanded Tumor-infiltrating Lymphocytes From Soft Tissue Sarcoma Have Tumor-specific Function.
John E Mullinax, MacLean Hall, +12 authors, Shari Pilon-Thomas.
J Immunother, 2021 Jan 15; 44(2). PMID: 33443972    Free PMC article.
Adaptive T cell immunotherapy in cancer.
Dongdong Ti, Miaomiao Bai, +5 authors, Weidong Han.
Sci China Life Sci, 2020 Jul 28; 64(3). PMID: 32712831
Quantifying the limits of CAR T-cell delivery in mice and men.
Liam V Brown, Eamonn A Gaffney, +2 authors, Mark C Coles.
J R Soc Interface, 2021 Mar 04; 18(176). PMID: 33653113    Free PMC article.
Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.
Joao Santos, Camilla Heiniö, +7 authors, Akseli Hemminki.
Cells, 2021 May 01; 10(5). PMID: 33922052    Free PMC article.
Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy.
Cristina Zalfa, Silke Paust.
Front Immunol, 2021 May 25; 12. PMID: 34025641    Free PMC article.
Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy.
Abraham Nissani, Shaked Lev-Ari, +8 authors, Michal J Besser.
J Immunother Cancer, 2021 May 16; 9(5). PMID: 33990415    Free PMC article.
Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma.
Chantal Saberian, Rodabe N Amaria, +20 authors, Chantale Bernatchez.
J Immunother Cancer, 2021 May 23; 9(5). PMID: 34021033    Free PMC article.
T cell stemness and dysfunction in tumors are triggered by a common mechanism.
Suman Kumar Vodnala, Robert Eil, +16 authors, Nicholas P Restifo.
Science, 2019 Mar 30; 363(6434). PMID: 30923193    Free PMC article.
Highly Cited.
Immersion in the search for effective cancer immunotherapies.
Steven A Rosenberg.
Mol Med, 2021 Jun 18; 27(1). PMID: 34134616    Free PMC article.
CAR T cell therapy as a promising approach in cancer immunotherapy: challenges and opportunities.
Maryam Akhoundi, Mahsa Mohammadi, +2 authors, Nashmin Fayazi.
Cell Oncol (Dordr), 2021 Mar 25; 44(3). PMID: 33759063
Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer.
Amrendra Kumar, Reese Watkins, Anna E Vilgelm.
Front Immunol, 2021 Jun 19; 12. PMID: 34140957    Free PMC article.
Stem Cell Theory of Cancer: Implications of a Viral Etiology in Certain Malignancies.
Shi-Ming Tu.
Cancers (Basel), 2021 Jul 03; 13(11). PMID: 34205851    Free PMC article.
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
Elena Shklovskaya, Helen Rizos.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201655    Free PMC article.
Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer.
Alia Ghoneum, Sameh Almousa, +6 authors, Neveen Said.
Semin Cancer Biol, 2021 Jan 22; 77. PMID: 33476723    Free PMC article.
Anti-tumour effect of neo-antigen-reactive T cells induced by RNA mutanome vaccine in mouse lung cancer.
Jiaxing Sun, Jing Zhang, +10 authors, Qiang Li.
J Cancer Res Clin Oncol, 2021 Jul 23; 147(11). PMID: 34291357    Free PMC article.
Prospects and Challenges for T Cell-Based Therapies of HCC.
Norman Woller, Sophie Anna Engelskircher, Thomas Wirth, Heiner Wedemeyer.
Cells, 2021 Jul 03; 10(7). PMID: 34209393    Free PMC article.
Cell Fate Reprogramming in the Era of Cancer Immunotherapy.
Olga Zimmermannova, Inês Caiado, Alexandra G Ferreira, Carlos-Filipe Pereira.
Front Immunol, 2021 Aug 10; 12. PMID: 34367185    Free PMC article.
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality.
Sarah Bonte, Stijn de Munter, +10 authors, Tessa Kerre.
Oncoimmunology, 2021 Aug 10; 10(1). PMID: 34367734    Free PMC article.
The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives.
Aymara Sancho-Araiz, Victor Mangas-Sanjuan, Iñaki F Trocóniz.
Pharmaceutics, 2021 Aug 11; 13(7). PMID: 34371708    Free PMC article.
Adoptive cell therapy using tumor-infiltrating lymphocytes for melanoma refractory to immune-checkpoint inhibitors.
Ikuko Hirai, Takeru Funakoshi, +17 authors, Yutaka Kawakami.
Cancer Sci, 2021 Jun 09; 112(8). PMID: 34101300    Free PMC article.
Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies.
Hannah M Knochelmann, Amalia M Rivera-Reyes, +12 authors, Chrystal M Paulos.
Oncoimmunology, 2021 Aug 20; 10(1). PMID: 34408920    Free PMC article.
Targeting Tumor-Rejection Antigens in Melanoma With Tumor-Infiltrating Lymphocytes.
Paul B Chapman.
J Clin Oncol, 2021 Jun 05; 39(24). PMID: 34086482    Free PMC article.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence.
Ying Xu, Guan-Hua Su, +3 authors, Yi-Zhou Jiang.
Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417437    Free PMC article.
IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model.
Eun M Yu, Eunjung Cho, +7 authors, Beom K Choi.
Cells, 2021 Aug 28; 10(8). PMID: 34440787    Free PMC article.
The State of Immunotherapy in Hepatobiliary Cancers.
Farhan Z Ilyas, Joal D Beane, Timothy M Pawlik.
Cells, 2021 Aug 28; 10(8). PMID: 34440865    Free PMC article.
The Hidden Treasures of Preoperative Blood Assessment in Oral Cancer: A Potential Source of Biomarkers.
Ana Caruntu, Liliana Moraru, +3 authors, Cristiana Tanase.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503285    Free PMC article.
Engineered in vitro tumor models for cell-based immunotherapy.
Yuta Ando, Chelsea Mariano, Keyue Shen.
Acta Biomater, 2021 Apr 16; 132. PMID: 33857692    Free PMC article.
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade.
Ravi B Patel, Reinier Hernandez, +19 authors, Zachary S Morris.
Sci Transl Med, 2021 Jul 16; 13(602). PMID: 34261797    Free PMC article.
Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung.
Ioannis Morianos, Aikaterini Tsitsopoulou, +8 authors, Maria Semitekolou.
J Exp Clin Cancer Res, 2021 Sep 23; 40(1). PMID: 34548096    Free PMC article.
The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer.
Ammarina Beumer-Chuwonpad, Renske L R E Taggenbrock, T An Ngo, Klaas P J M van Gisbergen.
Cells, 2021 Sep 29; 10(9). PMID: 34571883    Free PMC article.
Tumour-intrinsic resistance to immune checkpoint blockade.
Anusha Kalbasi, Antoni Ribas.
Nat Rev Immunol, 2019 Oct 02; 20(1). PMID: 31570880    Free PMC article.
Highly Cited. Review.
Adoptive cell therapy with tumor-infiltrating lymphocytes supported by checkpoint inhibition across multiple solid cancer types.
Anders Handrup Kverneland, Christopher Aled Chamberlain, +10 authors, Inge Marie Svane.
J Immunother Cancer, 2021 Oct 06; 9(10). PMID: 34607899    Free PMC article.
Improving CAR T-Cell Persistence.
Violena Pietrobon, Lauren Anne Todd, +3 authors, Francesco Marincola.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639168    Free PMC article.
Cancer therapy in mice using a pure population of CD8+ T cell specific to the AH1 tumor rejection antigen.
Marco Stringhini, Ilaria Spadafora, +4 authors, Dario Neri.
Cancer Immunol Immunother, 2021 Apr 03; 70(11). PMID: 33796916    Free PMC article.
Using chimeric antigen receptor T-cell therapy to fight glioblastoma multiforme: past, present and future developments.
David C Soler, Amber Kerstetter-Fogle, Thomas S McCormick, Andrew E Sloan.
J Neurooncol, 2021 Nov 27; 156(1). PMID: 34825292    Free PMC article.
A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation.
Jerome H Check, Diane L Check.
Int J Mol Sci, 2021 Nov 28; 22(22). PMID: 34830233    Free PMC article.
From Hematopoietic Stem Cell Transplantation to Chimeric Antigen Receptor Therapy: Advances, Limitations and Future Perspectives.
Elisaveta Voynova, Damian Kovalovsky.
Cells, 2021 Nov 28; 10(11). PMID: 34831068    Free PMC article.
The Emerging Interplay Between Recirculating and Tissue-Resident Memory T Cells in Cancer Immunity: Lessons Learned From PD-1/PD-L1 Blockade Therapy and Remaining Gaps.
Silvia Gitto, Ambra Natalini, Fabrizio Antonangeli, Francesca Di Rosa.
Front Immunol, 2021 Dec 07; 12. PMID: 34867987    Free PMC article.
Neoantigen-Reactive T Cells: The Driving Force behind Successful Melanoma Immunotherapy.
Lindy Davis, Ashley Tarduno, Yong-Chen Lu.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885172    Free PMC article.
Retargeting IL-2 Signaling to NKG2D-Expressing Tumor-Infiltrating Leukocytes Improves Adoptive Transfer Immunotherapy.
Anirban Banerjee, Dongge Li, +12 authors, Alexander Sasha Krupnick.
J Immunol, 2021 Jun 23; 207(1). PMID: 34155069    Free PMC article.
In silico-labeled ghost cytometry.
Masashi Ugawa, Yoko Kawamura, +21 authors, Sadao Ota.
Elife, 2021 Dec 22; 10. PMID: 34930522    Free PMC article.
CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis.
Karen B Whittington, Amanda Prislovsky, +3 authors, Edward F Rosloniec.
J Immunol, 2021 Nov 26; 208(1). PMID: 34819392    Free PMC article.
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy.
Myriam Ben Khelil, Yann Godet, +3 authors, Romain Loyon.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008422    Free PMC article.
Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on "Off-the-Shelf" T Cell Therapy Using iPSC Technology and Gene Editing.
Yoshiki Furukawa, Yasuharu Hamano, +5 authors, Miki Ando.
Cells, 2022 Jan 22; 11(2). PMID: 35053386    Free PMC article.
Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting.
Zongjie Wang, Sharif Ahmed, +7 authors, Shana O Kelley.
Nat Biomed Eng, 2022 Jan 29; 6(2). PMID: 35087171
Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes.
Parin Shah, Marie-Andrée Forget, +25 authors, Chantale Bernatchez.
J Immunother Cancer, 2022 Feb 04; 10(2). PMID: 35110355    Free PMC article.
Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy.
Ross E Staudt, Robert D Carlson, Adam E Snook.
Cancer Biol Ther, 2022 Feb 08; 23(1). PMID: 35129050    Free PMC article.
Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro.
Kavita R Manhas, Pamela A Marshall, +4 authors, Joseph N Blattman.
Front Immunol, 2022 Feb 15; 13. PMID: 35154092    Free PMC article.
CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection.
Mary S Pampusch, Hadia M Abdelaal, +9 authors, Pamela J Skinner.
PLoS Pathog, 2022 Feb 08; 18(2). PMID: 35130312    Free PMC article.
Multi-Level Computational Modeling of Anti-Cancer Dendritic Cell Vaccination Utilized to Select Molecular Targets for Therapy Optimization.
Xin Lai, Christine Keller, +3 authors, Julio Vera.
Front Cell Dev Biol, 2022 Feb 22; 9. PMID: 35186943    Free PMC article.
A randomized phase 2 trial of idiotype vaccination and adoptive autologous T-cell transfer in patients with multiple myeloma.
Muzaffar H Qazilbash, Neeraj Y Saini, +24 authors, Larry W Kwak.
Blood, 2021 Sep 15; 139(9). PMID: 34521108    Free PMC article.
T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion.
Laura T Morton, Tassilo L A Wachsmann, +5 authors, Mirjam H M Heemskerk.
J Immunother Cancer, 2022 Mar 16; 10(3). PMID: 35288464    Free PMC article.
The Role of Myeloid Cells in Hepatotoxicity Related to Cancer Immunotherapy.
Cathrin L C Gudd, Lucia A Possamai.
Cancers (Basel), 2022 Apr 24; 14(8). PMID: 35454819    Free PMC article.
KRAS: A Druggable Target in Colon Cancer Patients.
Francesca Negri, Lorena Bottarelli, Gian Luigi de'Angelis, Letizia Gnetti.
Int J Mol Sci, 2022 Apr 24; 23(8). PMID: 35456940    Free PMC article.
Emerging Strategies in TCR-Engineered T Cells.
Fang Wei, Xiao-Xia Cheng, John Zhao Xue, Shao-An Xue.
Front Immunol, 2022 Apr 19; 13. PMID: 35432319    Free PMC article.