Journal Article
. 2003 Apr;21(8).
doi: 10.1200/JCO.2003.09.081.

Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741

Marc L Citron 1 Donald A Berry  Constance Cirrincione  Clifford Hudis  Eric P Winer  William J Gradishar  Nancy E Davidson  Silvana Martino  Robert Livingston  James N Ingle  Edith A Perez  John Carpenter  David Hurd  James F Holland  Barbara L Smith  Carolyn I Sartor  Eleanor H Leung  Jeffrey Abrams  Richard L Schilsky  Hyman B Muss  Larry Norton  
  • PMID: 12668651
  •     338 citations


Purpose: Using a 2 x 2 factorial design, we studied the adjuvant chemotherapy of women with axillary node-positive breast cancer to compare sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) with concurrent doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T) for disease-free (DFS) and overall survival (OS); to determine whether the dose density of the agents improves DFS and OS; and to compare toxicities.

Patients And Methods: A total of 2,005 female patients were randomly assigned to receive one of the following regimens: (I) sequential A x 4 (doses) --> T x 4 --> C x 4 with doses every 3 weeks, (II) sequential A x 4 --> T x 4 --> C x 4 every 2 weeks with filgrastim, (III) concurrent AC x 4 --> T x 4 every 3 weeks, or (IV) concurrent AC x 4 --> T x 4 every 2 weeks with filgrastim.

Results: A protocol-specified analysis was performed at a median follow-up of 36 months: 315 patients had experienced relapse or died, compared with 515 expected treatment failures. Dose-dense treatment improved the primary end point, DFS (risk ratio [RR] = 0.74; P =.010), and OS (RR = 0.69; P =.013). Four-year DFS was 82% for the dose-dense regimens and 75% for the others. There was no difference in either DFS or OS between the concurrent and sequential schedules. There was no interaction between density and sequence. Severe neutropenia was less frequent in patients who received the dose-dense regimens.

Conclusion: Dose density improves clinical outcomes significantly, despite the lower than expected number of events at this time. Sequential chemotherapy is as effective as concurrent chemotherapy.

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Optimizing dose-dense regimens for early-stage breast cancer.
Patrick G Morris, Clifford A Hudis.
Nat Rev Clin Oncol, 2010 Dec 01; 7(12). PMID: 21116238
Dose dense cyclophosphamide, methotrexate, fluorouracil is feasible at 14-day intervals: a pilot study of every-14-day dosing as adjuvant therapy for breast cancer.
Pamela Drullinsky, Steven M Sugarman, +15 authors, Clifford Hudis.
Clin Breast Cancer, 2010 Dec 15; 10(6). PMID: 21147686    Free PMC article.
Lymphocyte subpopulation and dendritic cell phenotyping during antineoplastic therapy in human solid tumors.
Sara Mariucci, Bianca Rovati, +4 authors, Marco Danova.
Clin Exp Med, 2010 Dec 17; 11(4). PMID: 21161672
Phase III comparison of standard doxorubicin and cyclophosphamide versus weekly doxorubicin and daily oral cyclophosphamide plus granulocyte colony-stimulating factor as neoadjuvant therapy for inflammatory and locally advanced breast cancer: SWOG 0012.
Georgiana K Ellis, William E Barlow, +6 authors, Robert B Livingston.
J Clin Oncol, 2011 Jan 12; 29(8). PMID: 21220618    Free PMC article.
Phase i study of 'dose-dense' pemetrexed plus carboplatin/radiotherapy for locally advanced non-small cell lung carcinoma.
Xinglei Shen, Albert Denittis, +6 authors, Mitchell Machtay.
Radiat Oncol, 2011 Feb 18; 6. PMID: 21324160    Free PMC article.
A feasibility study of bevacizumab plus dose-dense doxorubicin-cyclophosphamide (AC) followed by nanoparticle albumin-bound paclitaxel in early-stage breast cancer.
Heather L McArthur, Hope Rugo, +30 authors, Maura N Dickler.
Clin Cancer Res, 2011 Feb 26; 17(10). PMID: 21350003    Free PMC article.
A Canadian economic analysis of U.S. Oncology Adjuvant Trial 9735.
L M Bernard, S Verma, +4 authors, S E Jones.
Curr Oncol, 2011 Apr 21; 18(2). PMID: 21505597    Free PMC article.
Cancer and Leukemia Group B Pathology Committee guidelines for tissue microarray construction representing multicenter prospective clinical trial tissues.
David L Rimm, Torsten O Nielsen, +18 authors, Cancer and Leukemia Group B Pathology Committee.
J Clin Oncol, 2011 Apr 27; 29(16). PMID: 21519016    Free PMC article.
Clinical implications of cancer self-seeding.
Elizabeth Comen, Larry Norton, Joan Massagué.
Nat Rev Clin Oncol, 2011 Apr 28; 8(6). PMID: 21522121
Highly Cited. Review.
Adjuvant chemotherapy for breast cancer in older women: emerging evidence to aid in decision making.
Gretchen Kimmick.
Curr Treat Options Oncol, 2011 Jun 04; 12(3). PMID: 21638199
Neoadjuvant dose-dense gemcitabine plus docetaxel and vinorelbine plus epirubicin for operable breast cancer: improved prognosis in triple-negative tumors.
Jacques Medioni, Cyrille Huchon, +7 authors, Eric Levy.
Drugs R D, 2011 Jun 18; 11(2). PMID: 21679005    Free PMC article.
G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonist.
Tali Voloshin, Svetlana Gingis-Velitski, +6 authors, Yuval Shaked.
Blood, 2011 Jun 21; 118(12). PMID: 21685373    Free PMC article.
Paclitaxel efficacy and toxicity in older women with metastatic breast cancer: combined analysis of CALGB 9342 and 9840.
S M Lichtman, A Hurria, +6 authors, Cancer and Leukemia Group B.
Ann Oncol, 2011 Jun 23; 23(3). PMID: 21693770    Free PMC article.
The treatment of early breast cancer in women over the age of 70.
A Ring, M Reed, +6 authors, R Coleman.
Br J Cancer, 2011 Jun 23; 105(2). PMID: 21694726    Free PMC article.
Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011.
A Goldhirsch, W C Wood, +4 authors, Panel members.
Ann Oncol, 2011 Jun 29; 22(8). PMID: 21709140    Free PMC article.
Highly Cited.
Sustained platelet-sparing effect of weekly low dose paclitaxel allows effective, tolerable delivery of extended dose dense weekly carboplatin in platinum resistant/refractory epithelial ovarian cancer.
Rohini Sharma, Janet Graham, Sarah Blagden, Hani Gabra.
BMC Cancer, 2011 Jul 13; 11. PMID: 21745358    Free PMC article.
Efficacy of taxanes as adjuvant treatment of breast cancer: a review and meta-analysis of randomised clinical trials.
Jordi Ginés, Eliazar Sabater, +3 authors, Miguel A Casado.
Clin Transl Oncol, 2011 Jul 22; 13(7). PMID: 21775276
A phase II pilot trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node positive breast cancer: a trial coordinated by the Eastern Cooperative Oncology Group.
K D Miller, A O'Neill, +2 authors, G W Sledge.
Ann Oncol, 2011 Aug 09; 23(2). PMID: 21821545    Free PMC article.
Accelerated BEP: a phase I trial of dose-dense BEP for intermediate and poor prognosis metastatic germ cell tumour.
Y Rimmer, J Chester, +9 authors, M V Williams.
Br J Cancer, 2011 Aug 19; 105(6). PMID: 21847130    Free PMC article.
What does physics have to do with cancer?
Franziska Michor, Jan Liphardt, Mauro Ferrari, Jonathan Widom.
Nat Rev Cancer, 2011 Aug 19; 11(9). PMID: 21850037    Free PMC article.
Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors.
Matthew J Olnes, Andrea Poon, +9 authors, Elaine M Sloand.
Transfusion, 2011 Sep 03; 52(3). PMID: 21883270    Free PMC article.
US Insurance Program's Experience With a Multigene Assay for Early-Stage Breast Cancer.
John Hornberger, Rebecca Chien, Katie Krebs, Louis Hochheiser.
J Oncol Pract, 2011 Sep 03; 7(3 Suppl). PMID: 21886510    Free PMC article.
High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer.
E Brain, C Levy, +12 authors, P Fumoleau.
Br J Cancer, 2011 Oct 20; 105(10). PMID: 22009030    Free PMC article.
Effect of socioeconomic status as measured by education level on survival in breast cancer clinical trials.
James E Herndon, Alice B Kornblith, Jimmie C Holland, Electra D Paskett.
Psychooncology, 2011 Oct 25; 22(2). PMID: 22021121    Free PMC article.
Phase III randomized trial of dose intensive neoadjuvant chemotherapy with or without G-CSF in locally advanced breast cancer: long-term results.
Banu K Arun, Kapil Dhinghra, +16 authors, Gabriel N Hortobagyi.
Oncologist, 2011 Nov 02; 16(11). PMID: 22042783    Free PMC article.
Second malignancies among elderly survivors of cancer.
Ari M VanderWalde, Arti Hurria.
Oncologist, 2011 Nov 02; 16(11). PMID: 22042787    Free PMC article.
How do I treat "triple-negative" disease.
Christos Vaklavas, Andres Forero-Torres.
Curr Treat Options Oncol, 2011 Nov 04; 12(4). PMID: 22048876
Adjuvant therapy for HER2+ breast cancer: practice, perception, and toxicity.
Gabrielle Rocque, Adedayo Onitilo, +8 authors, Mark E Burkard.
Breast Cancer Res Treat, 2011 Nov 09; 131(2). PMID: 22065290    Free PMC article.
AGO Recommendations for Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer. Update 2011.
Christoph Thomssen, Anton Scharl, Nadia Harbeck.
Breast Care (Basel), 2011 Dec 14; 6(4). PMID: 22164127    Free PMC article.
Automated plan-recognition of chemotherapy protocols.
Haresh Bhatia, Mia Levy.
AMIA Annu Symp Proc, 2011 Dec 24; 2011. PMID: 22195061    Free PMC article.
Incidence of acute myeloid leukemia after breast cancer.
Caterina Giovanna Valentini, Luana Fianchi, +3 authors, Livio Pagano.
Mediterr J Hematol Infect Dis, 2012 Jan 06; 3(1). PMID: 22220266    Free PMC article.
Scope of symptoms and self-management strategies for chemotherapy-induced peripheral neuropathy in breast cancer patients.
Rebecca M Speck, Angela DeMichele, +4 authors, Frances K Barg.
Support Care Cancer, 2012 Jan 11; 20(10). PMID: 22231480
Impact of a reduced dose intensity of adjuvant anthracycline based chemotherapy in a population-based cohort of stage I-II breast cancers.
A V Tinker, C Speers, +2 authors, S Chia.
Ecancermedicalscience, 2008 Jan 01; 2. PMID: 22275960    Free PMC article.
Uptake and economic impact of first-cycle colony-stimulating factor use during adjuvant treatment of breast cancer.
Dawn L Hershman, Elizabeth T Wilde, +4 authors, Alfred I Neugut.
J Clin Oncol, 2012 Feb 09; 30(8). PMID: 22312106    Free PMC article.
Triple-negative breast cancer: adjuvant therapeutic options.
Ayca Gucalp, Tiffany A Traina.
Chemother Res Pract, 2012 Feb 09; 2011. PMID: 22312556    Free PMC article.
A way forward on the medically appropriate use of white cell growth factors.
Thomas J Smith, Bruce E Hillner.
J Clin Oncol, 2012 Mar 01; 30(14). PMID: 22370327    Free PMC article.
The dynamics of drug resistance: a mathematical perspective.
Orit Lavi, Michael M Gottesman, Doron Levy.
Drug Resist Updat, 2012 Mar 06; 15(1-2). PMID: 22387162    Free PMC article.
Increased efficacy of a dose-dense regimen of neoadjuvant chemotherapy in breast carcinoma: a retrospective analysis.
Bohuslav Melichar, Helena Hornychová, +7 authors, Aleš Ryška.
Med Oncol, 2012 Mar 07; 29(4). PMID: 22392196
Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system.
Mohamed Naguib, Jijun J Xu, +6 authors, Walter N Hittelman.
Anesth Analg, 2012 Mar 07; 114(5). PMID: 22392969    Free PMC article.
Hematopoietic growth factors: personalization of risks and benefits.
Shannon Puhalla, Saveri Bhattacharya, Nancy E Davidson.
Mol Oncol, 2012 Apr 14; 6(2). PMID: 22497867    Free PMC article.
Prevention of pegfilgrastim-induced bone pain: a phase III double-blind placebo-controlled randomized clinical trial of the university of rochester cancer center clinical community oncology program research base.
Jeffrey J Kirshner, Charles E Heckler, +4 authors, Gary R Morrow.
J Clin Oncol, 2012 Apr 18; 30(16). PMID: 22508813    Free PMC article.
Choosing the best trastuzumab-based adjuvant chemotherapy regimen: should we abandon anthracyclines?
Harold J Burstein, Martine J Piccart-Gebhart, +6 authors, Clifford A Hudis.
J Clin Oncol, 2012 May 23; 30(18). PMID: 22614986    Free PMC article.
Decline in the use of anthracyclines for breast cancer.
Sharon H Giordano, Yu-Li Lin, +2 authors, James S Goodwin.
J Clin Oncol, 2012 May 23; 30(18). PMID: 22614988    Free PMC article.
SEOM clinical guidelines for myeloid growth factors.
José Muñoz Langa, Pere Gascón, Javier de Castro, SEOM (Spanish Society of Clinical Oncology).
Clin Transl Oncol, 2012 Jun 23; 14(7). PMID: 22721792
Austrian Arbeitsgemeinschaft für Gynäkologische Onkologie (AGO) guideline for prophylaxis with granulocyte colony-stimulating factors (G-CSF) in gynecologic malignancies, including breast cancer.
Edgar Petru, Alain Gustave Zeimet, +9 authors, Austrian Arbeitsgemeinschaft für Gynäkologische Onkologie (AGO).
Wien Klin Wochenschr, 2012 Jun 29; 124(11-12). PMID: 22739650
Recent advances in adjuvant systemic treatment for breast cancer: all systems go!
P N Fishman, S Verma.
Curr Oncol, 2006 Oct 01; 13(5). PMID: 22792012    Free PMC article.
Six cycles of doxorubicin and cyclophosphamide or Paclitaxel are not superior to four cycles as adjuvant chemotherapy for breast cancer in women with zero to three positive axillary nodes: Cancer and Leukemia Group B 40101.
Lawrence N Shulman, Constance T Cirrincione, +12 authors, Clifford Hudis.
J Clin Oncol, 2012 Jul 25; 30(33). PMID: 22826271    Free PMC article.
A Phase II trial of docetaxel and carboplatin administered every 2 weeks as preoperative therapy for stage II or III breast cancer: NCCTG study N0338.
Vivek Roy, Barbara A Pockaj, +5 authors, Edith A Perez.
Am J Clin Oncol, 2012 Aug 08; 36(6). PMID: 22868240    Free PMC article.
Translating mathematical modeling of tumor growth patterns into novel therapeutic approaches for breast cancer.
Elizabeth Comen, Patrick G Morris, Larry Norton.
J Mammary Gland Biol Neoplasia, 2012 Sep 27; 17(3-4). PMID: 23011603
Senior adult oncology: three cases of advanced cancer in patients of advanced age.
Gloria J Morris, Kristine Swartz, +4 authors, Kathryn R Chan.
Semin Oncol, 2012 Oct 09; 39(5). PMID: 23040260    Free PMC article.
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
Richard B Womer, Daniel C West, +8 authors, Aaron R Weiss.
J Clin Oncol, 2012 Oct 24; 30(33). PMID: 23091096    Free PMC article.
Highly Cited.
Patterns and predictors of breast cancer chemotherapy use in Kaiser Permanente Northern California, 2004-2007.
Allison W Kurian, Daphne Y Lichtensztajn, +8 authors, Scarlett L Gomez.
Breast Cancer Res Treat, 2012 Nov 10; 137(1). PMID: 23139057    Free PMC article.
Weight-based chemotherapy dosing in obese patients with cancer: back to the future.
Gary H Lyman.
J Oncol Pract, 2012 Nov 28; 8(4). PMID: 23181001    Free PMC article.
Efficacy and feasibility of neoadjuvant chemotherapy with FEC 100 followed by weekly paclitaxel for operable breast cancer.
Hidemi Kawajiri, Tsutomu Takashima, +5 authors, Kosei Hirakawa.
Oncol Lett, 2012 Dec 04; 4(4). PMID: 23205071    Free PMC article.
Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences.
Jun Ren, Lijun Di, +12 authors, Herbert Kim Lyerly.
Clin Transl Oncol, 2013 Jan 30; 15(10). PMID: 23359185
Publicly funded clinical trials and the future of cancer care.
Richard L Schilsky.
Oncologist, 2013 Feb 01; 18(2). PMID: 23363807    Free PMC article.
Advanced Urothelial Carcinoma: Overcoming Treatment Resistance through Novel Treatment Approaches.
Richard M Bambury, Jonathan E Rosenberg.
Front Pharmacol, 2013 Feb 08; 4. PMID: 23390417    Free PMC article.
CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel.
D L Hertz, S Roy, +5 authors, E C Dees.
Ann Oncol, 2013 Feb 16; 24(6). PMID: 23413280    Free PMC article.
Mobilization of Peripheral Blood Stem Cells Using Regimen Combining Docetaxel with Granulocyte Colony-stimulating Factor in Breast Cancer Patients.
Jing Yu, Jun Ren, +8 authors, Chun-Rong Zhang.
Chin J Cancer Res, 2011 Mar 01; 23(1). PMID: 23467566    Free PMC article.
Center of cancer systems biology second annual workshop--tumor metronomics: timing and dose level dynamics.
Philip Hahnfeldt, Lynn Hlatky, Giannoula Lakka Klement.
Cancer Res, 2013 Mar 16; 73(10). PMID: 23492368    Free PMC article.
Different administration strategies with paclitaxel induce distinct phenotypes of multidrug resistance in breast cancer cells.
Donghai Jiang, Meihua Sui, +2 authors, Weimin Fan.
Cancer Lett, 2013 Mar 19; 335(2). PMID: 23499896    Free PMC article.
Future vision for the quality assurance of oncology clinical trials.
Thomas J Fitzgerald, Maryann Bishop-Jodoin, +15 authors, Marcia Urie.
Front Oncol, 2013 Mar 20; 3. PMID: 23508883    Free PMC article.
Colony-stimulating factors for febrile neutropenia during cancer therapy.
Charles L Bennett, Benjamin Djulbegovic, LeAnn B Norris, James O Armitage.
N Engl J Med, 2013 Mar 22; 368(12). PMID: 23514290    Free PMC article.
Second-line treatment in advanced pancreatic cancer: a comprehensive analysis of published clinical trials.
O E Rahma, A Duffy, +2 authors, T F Greten.
Ann Oncol, 2013 May 15; 24(8). PMID: 23670093    Free PMC article.
Overview of major classes of plant-derived anticancer drugs.
Amr Amin, Hala Gali-Muhtasib, Matthias Ocker, Regine Schneider-Stock.
Int J Biomed Sci, 2009 Mar 01; 5(1). PMID: 23675107    Free PMC article.
A randomized, multi-center, open-label, phase II study of once-per-cycle DA-3031, a biosimilar pegylated G-CSF, compared with daily filgrastim in patients receiving TAC chemotherapy for early-stage breast cancer.
K H Park, J H Sohn, +12 authors, J H Seo.
Invest New Drugs, 2013 May 17; 31(5). PMID: 23677653
Docetaxel-induced skin toxicities in breast cancer patients subsequent to paclitaxel shortage: a case series and literature review.
Ming J Poi, Michael Berger, +6 authors, Robert Wesolowski.
Support Care Cancer, 2013 May 21; 21(10). PMID: 23686402    Free PMC article.
Prognosis in women with breast cancer and private extra insurance coverage.
Juan J Grau, Gabriel Zanon, +4 authors, Albert Biete.
Ann Surg Oncol, 2013 Jun 12; 20(9). PMID: 23754547    Free PMC article.
Treatment of breast cancer in young women: do we need more aggressive therapies?
Giuseppe Cancello, Emilia Montagna.
J Thorac Dis, 2013 Jul 03; 5 Suppl 1. PMID: 23819027    Free PMC article.
Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study.
József Zsiros, Laurence Brugieres, +17 authors, International Childhood Liver Tumours Strategy Group (SIOPEL).
Lancet Oncol, 2013 Jul 09; 14(9). PMID: 23831416    Free PMC article.
Chemotherapy dosing in overweight and obese patients with cancer.
Gary H Lyman, Alex Sparreboom.
Nat Rev Clin Oncol, 2013 Jul 17; 10(8). PMID: 23856744
Adding epoetin alfa to intense dose-dense adjuvant chemotherapy for breast cancer: randomized clinical trial.
Volker Moebus, Christian Jackisch, +12 authors, AGO Breast Study Group.
J Natl Cancer Inst, 2013 Jul 19; 105(14). PMID: 23860204    Free PMC article.
A new mathematical pharmacodynamic model of clonogenic cancer cell death by doxorubicin.
Jan Lankelma, Rafael Fernández Luque, +2 authors, Bob Kooi.
J Pharmacokinet Pharmacodyn, 2013 Jul 19; 40(4). PMID: 23864485
Definitive results of a phase III adjuvant trial comparing three chemotherapy regimens in women with operable, node-positive breast cancer: the NSABP B-38 trial.
Sandra M Swain, Gong Tang, +17 authors, Norman Wolmark.
J Clin Oncol, 2013 Aug 14; 31(26). PMID: 23940225    Free PMC article.
Tumor histological subtyping determined by hormone receptors and HER2 status defines different pathological complete response and outcome to dose-dense neoadjuvant chemotherapy in breast cancer patients.
A Sánchez-Muñoz, Y Plata-Fernández, +7 authors, P Sánchez-Rovira.
Clin Transl Oncol, 2013 Oct 03; 16(6). PMID: 24085576
Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial.
Mark R Gilbert, Meihua Wang, +17 authors, Minesh P Mehta.
J Clin Oncol, 2013 Oct 09; 31(32). PMID: 24101040    Free PMC article.
Highly Cited.
Dose-dense epirubicin and cyclophosphamide followed by docetaxel as adjuvant chemotherapy in node-positive breast cancer.
Hamid Reza Mirzaei, Parisa Sabet Rasekh, +5 authors, Parastoo Hajian.
Int J Breast Cancer, 2013 Nov 05; 2013. PMID: 24187626    Free PMC article.
A prospective observational study to evaluate G-CSF usage in patients with solid tumors receiving myelosuppressive chemotherapy in Italian clinical oncology practice.
S Barni, V Lorusso, +10 authors, P Pronzato.
Med Oncol, 2013 Dec 07; 31(1). PMID: 24307348
Feasibility of 4 cycles of docetaxel and cyclophosphamide every 14 days as an adjuvant regimen for breast cancer: a Wisconsin Oncology Network study.
Mark E Burkard, Kari B Wisinski, +11 authors, Amye J Tevaarwerk.
Clin Breast Cancer, 2013 Dec 18; 14(3). PMID: 24342730    Free PMC article.
Breast cancer follow-up strategies in randomized phase III adjuvant clinical trials: a systematic review.
Isabella Sperduti, Patrizia Vici, +6 authors, Clara Natoli.
J Exp Clin Cancer Res, 2014 Jan 21; 32. PMID: 24438135    Free PMC article.
Systematic Review.
Targeted therapy in triple-negative metastatic breast cancer: a systematic review and meta-analysis.
Otávio Clark, Tobias Engel Ayer Botrel, Luciano Paladini, Mariana Bhering Andrade Ferreira.
Core Evid, 2014 Jan 31; 9. PMID: 24476748    Free PMC article.
Retrospective analysis of the use of G-CSF and its impact on dose response for anthracycline plus taxane-based schedules in early breast cancer.
J A Pérez-Fidalgo, B Bermejo, +7 authors, A Lluch.
Clin Transl Oncol, 2014 Feb 18; 16(9). PMID: 24532305    Free PMC article.
Evolution of acquired resistance to anti-cancer therapy.
Jasmine Foo, Franziska Michor.
J Theor Biol, 2014 Apr 01; 355. PMID: 24681298    Free PMC article.
Highly Cited. Review.
Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.
Hanna K Sanoff, Allison M Deal, +15 authors, Hyman B Muss.
J Natl Cancer Inst, 2014 Apr 01; 106(4). PMID: 24681605    Free PMC article.
Highly Cited.
Phase II trial of neoadjuvant weekly nanoparticle albumin-bound paclitaxel, carboplatin, and biweekly bevacizumab therapy in women with clinical stage II or III HER2-negative breast cancer.
Ewa Mrózek, Rachel Layman, +4 authors, Charles L Shapiro.
Clin Breast Cancer, 2014 Apr 08; 14(4). PMID: 24703985    Free PMC article.
Patterns of chemotherapy-associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study.
Eva Culakova, Ramya Thota, +5 authors, Gary H Lyman.
Cancer Med, 2014 Apr 08; 3(2). PMID: 24706592    Free PMC article.
Interdisciplinary GoR level III Guidelines for the Diagnosis, Therapy and Follow-up Care of Breast Cancer: Short version - AWMF Registry No.: 032-045OL AWMF-Register-Nummer: 032-045OL - Kurzversion 3.0, Juli 2012.
R Kreienberg, U-S Albert, +3 authors, A Wöckel.
Geburtshilfe Frauenheilkd, 2014 Apr 29; 73(6). PMID: 24771925    Free PMC article.
Second malignancies after breast cancer: The impact of adjuvant therapy.
Chunhui Dong, Ling Chen.
Mol Clin Oncol, 2014 Apr 29; 2(3). PMID: 24772296    Free PMC article.
The mathematician versus the malignancy.
Elie Dolgin.
Nat Med, 2014 May 09; 20(5). PMID: 24804745
Breast cancer and aging: results of the U13 conference breast cancer panel.
M F Barginear, H Muss, +5 authors, A Hurria.
Breast Cancer Res Treat, 2014 May 23; 146(1). PMID: 24847891    Free PMC article.
Cost-effectiveness analysis of docetaxel versus weekly paclitaxel in adjuvant treatment of regional breast cancer in New Zealand.
Rachel Webber-Foster, Giorgi Kvizhinadze, Gareth Rivalland, Tony Blakely.
Pharmacoeconomics, 2014 May 27; 32(7). PMID: 24859241
Cardiac safety results from a phase II, open-label, multicenter, pilot study of two docetaxel-based regimens plus bevacizumab for the adjuvant treatment of subjects with node-positive or high-risk node-negative breast cancer.
Sara A Hurvitz, Linda D Bosserman, +6 authors, Dennis J Slamon.
Springerplus, 2014 May 27; 3. PMID: 24860718    Free PMC article.
Risk of hospitalization according to chemotherapy regimen in early-stage breast cancer.
Carlos H Barcenas, Jiangong Niu, +6 authors, Sharon H Giordano.
J Clin Oncol, 2014 May 29; 32(19). PMID: 24868022    Free PMC article.
Past, present, and future challenges in breast cancer treatment.
George W Sledge, Eleftherios P Mamounas, +3 authors, Antonio C Wolff.
J Clin Oncol, 2014 Jun 04; 32(19). PMID: 24888802    Free PMC article.
Comparison of doxorubicin and cyclophosphamide versus single-agent paclitaxel as adjuvant therapy for breast cancer in women with 0 to 3 positive axillary nodes: CALGB 40101 (Alliance).
Lawrence N Shulman, Donald A Berry, +12 authors, Eric P Winer.
J Clin Oncol, 2014 Jun 18; 32(22). PMID: 24934787    Free PMC article.
Neutropenia and relative dose intensity on adjuvant FOLFOX chemotherapy are not associated with survival for resected colon cancer.
Martin Smoragiewicz, Khodadad R Javaheri, Yaling Yin, Sharlene Gill.
J Gastrointest Cancer, 2014 Jul 12; 45(4). PMID: 25012517
Predicting response and survival in chemotherapy-treated triple-negative breast cancer.
A Prat, A Lluch, +35 authors, E Alba.
Br J Cancer, 2014 Aug 08; 111(8). PMID: 25101563    Free PMC article.
Adjuvant chemotherapy in breast cancer: To use or not to use, the anthracyclines.
Jennifer A Crozier, Abhisek Swaika, Alvaro Moreno-Aspitia.
World J Clin Oncol, 2014 Aug 13; 5(3). PMID: 25114866    Free PMC article.
Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer.
Timothy M Zagar, Zeljko Vujaskovic, +16 authors, Mark W Dewhirst.
Int J Hyperthermia, 2014 Aug 22; 30(5). PMID: 25144817    Free PMC article.
Preliminary Development and Evaluation of an Algorithm to Identify Breast Cancer Chemotherapy Toxicities Using Electronic Medical Records and Administrative Data.
Jeanne S Mandelblatt, Karl Huang, +13 authors, Larry Kushi.
J Oncol Pract, 2014 Aug 28; 11(1). PMID: 25161127    Free PMC article.
Chemotherapy in early breast cancer: when, how and which one?
Marcus Schmidt.
Breast Care (Basel), 2014 Sep 02; 9(3). PMID: 25177256    Free PMC article.
Dose-dense epirubicin and cyclophosphamide followed by weekly Paclitaxel in node-positive breast cancer.
Hamid Reza Mirzaei, Fatemeh Nasrollahi, +3 authors, Parastoo Hajian.
Chemother Res Pract, 2014 Oct 03; 2014. PMID: 25276426    Free PMC article.
Granulocyte colony-stimulating factors as prophylaxis against febrile neutropenia.
Sol Cortés de Miguel, Miguel Ángel Calleja-Hernández, Salomón Menjón-Beltrán, Inmaculada Vallejo-Rodríguez.
Support Care Cancer, 2014 Oct 07; 23(2). PMID: 25284722
Adjuvant Docetaxel and Cyclophosphamide (DC) with prophylactic granulocyte colony-stimulating factor (G-CSF) on days 8 &12 in breast cancer patients: a retrospective analysis.
Rinat Yerushalmi, Hadar Goldvaser, +10 authors, Salomon M Stemmer.
PLoS One, 2014 Oct 21; 9(10). PMID: 25330205    Free PMC article.
Update on adjuvant chemotherapy for early breast cancer.
Murtuza M Rampurwala, Gabrielle B Rocque, Mark E Burkard.
Breast Cancer (Auckl), 2014 Oct 23; 8. PMID: 25336961    Free PMC article.
Current treatment of early breast cancer: adjuvant and neoadjuvant therapy.
Elizabeth Miller, Hee Jin Lee, +3 authors, Bora Lim.
F1000Res, 2014 Nov 18; 3. PMID: 25400908    Free PMC article.
SWOG S0221: a phase III trial comparing chemotherapy schedules in high-risk early-stage breast cancer.
George T Budd, William E Barlow, +17 authors, Gabriel N Hortobagyi.
J Clin Oncol, 2014 Nov 26; 33(1). PMID: 25422488    Free PMC article.
Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity.
Joseph M Caster, Manish Sethi, +8 authors, Andrew Z Wang.
Nanoscale, 2015 Jan 15; 7(6). PMID: 25584654    Free PMC article.
Integrated PK-PD and agent-based modeling in oncology.
Zhihui Wang, Joseph D Butner, Vittorio Cristini, Thomas S Deisboeck.
J Pharmacokinet Pharmacodyn, 2015 Jan 16; 42(2). PMID: 25588379    Free PMC article.
Dose-dense biweekly docetaxel combined with 5-fluorouracil as first-line treatment in advanced gastric cancer: a phase II trial.
Jian Xiao, Yonghe Chen, +8 authors, Ping Lan.
Med Oncol, 2015 Jan 23; 32(2). PMID: 25609007
The Neoadjuvant Model Is Still the Future for Drug Development in Breast Cancer.
Angela DeMichele, Douglas Yee, +39 authors, Laura J Esserman.
Clin Cancer Res, 2015 Feb 26; 21(13). PMID: 25712686    Free PMC article.
Preemptive adefovir versus lamivudine for prevention of hepatitis B reactivation in chronic hepatitis B patients undergoing chemotherapy.
Edith Y Ho, Thomas Yau, +2 authors, George K K Lau.
Hepatol Int, 2015 Mar 20; 9(2). PMID: 25788197
An open-label, randomized, multicenter dose-finding study of once-per-cycle pegfilgrastim versus daily filgrastim in Chinese breast cancer patients receiving TAC chemotherapy.
Wei Zhang, Zhiwei Jiang, +2 authors, Jielai Xia.
Med Oncol, 2015 Mar 31; 32(5). PMID: 25820754
Adjuvant chemotherapy for early female breast cancer: a systematic review of the evidence for the 2014 Cancer Care Ontario systemic therapy guideline.
S Gandhi, G G Fletcher, +4 authors, M E Trudeau.
Curr Oncol, 2015 Apr 08; 22(Suppl 1). PMID: 25848343    Free PMC article.
Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations.
Balazs I Bodai, Phillip Tuso.
Perm J, 2015 Apr 23; 19(2). PMID: 25902343    Free PMC article.
Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741 (Alliance).
Jennifer A Ligibel, Constance T Cirrincione, +13 authors, William T Barry.
J Natl Cancer Inst, 2015 Jun 27; 107(9). PMID: 26113580    Free PMC article.
Optimal approach in early breast cancer: Adjuvant and neoadjuvant treatment.
J Ribeiro, B Sousa, F Cardoso.
EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217109    Free PMC article.
G-CSF and GM-CSF in Neutropenia.
Hrishikesh M Mehta, Michael Malandra, Seth J Corey.
J Immunol, 2015 Aug 09; 195(4). PMID: 26254266    Free PMC article.
Progress in adjuvant chemotherapy for breast cancer: an overview.
Jesus Anampa, Della Makower, Joseph A Sparano.
BMC Med, 2015 Aug 19; 13. PMID: 26278220    Free PMC article.
Highly Cited. Review.
Myelodysplastic syndrome and acute myeloid leukemia following adjuvant chemotherapy with and without granulocyte colony-stimulating factors for breast cancer.
Gregory S Calip, Judith A Malmgren, +2 authors, Henry G Kaplan.
Breast Cancer Res Treat, 2015 Oct 10; 154(1). PMID: 26450505    Free PMC article.
A Pilot Study of Dose-Dense Paclitaxel With Trastuzumab and Lapatinib for Node-negative HER2-Overexpressed Breast Cancer.
Neil M Iyengar, Monica N Fornier, +17 authors, Chau T Dang.
Clin Breast Cancer, 2015 Oct 12; 16(2). PMID: 26454612    Free PMC article.
Prophylactic long-acting granulocyte-colony stimulating factors (G-CSF) in gynecologic malignancies: an oncologic expert statement.
Edgar Petru, Christian F Singer, +12 authors, Alain-Gustave Zeimet.
Wien Med Wochenschr, 2015 Oct 17; 165(19-20). PMID: 26471371
Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small Cell Lung Cancer Patients.
Lin L Liu, Fei Li, William Pao, Franziska Michor.
PLoS One, 2015 Nov 05; 10(11). PMID: 26536620    Free PMC article.
Improving Cancer Treatment via Mathematical Modeling: Surmounting the Challenges Is Worth the Effort.
Franziska Michor, Kathryn Beal.
Cell, 2015 Nov 23; 163(5). PMID: 26590416    Free PMC article.
The mathematics of cancer: integrating quantitative models.
Philipp M Altrock, Lin L Liu, Franziska Michor.
Nat Rev Cancer, 2015 Nov 26; 15(12). PMID: 26597528
Highly Cited. Review.
Computational oncology--mathematical modelling of drug regimens for precision medicine.
Dominique Barbolosi, Joseph Ciccolini, +2 authors, Nicolas André.
Nat Rev Clin Oncol, 2015 Nov 26; 13(4). PMID: 26598946
Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation.
Keith Syson Chan.
Clin Cancer Res, 2015 Dec 17; 22(4). PMID: 26671994    Free PMC article.
Chemotherapy in Premenopausal Breast Cancer Patients.
Ann H Partridge.
Breast Care (Basel), 2015 Dec 22; 10(5). PMID: 26688676    Free PMC article.
A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities.
Jean E Abraham, Louise Hiller, +11 authors, Helena M Earl.
BMC Med, 2015 Dec 31; 13. PMID: 26715442    Free PMC article.
Adjuvant treatment for older women with invasive breast cancer.
Trevor A Jolly, Grant R Williams, +4 authors, Hyman B Muss.
Womens Health (Lond), 2016 Jan 16; 12(1). PMID: 26767315    Free PMC article.
Characterizing and quantifying the effects of breast cancer therapy using mathematical modeling.
Walter M Gregory, Christopher J Twelves, +4 authors, David A Cameron.
Breast Cancer Res Treat, 2016 Jan 20; 155(2). PMID: 26783036    Free PMC article.
Comparison of toxicity profile and tolerability between two standard of care paclitaxel-based adjuvant chemotherapy regimens in breast cancer.
Mohamed Alsharedi, Todd Gress, +2 authors, Maria Tria Tirona.
Med Oncol, 2016 Feb 18; 33(3). PMID: 26883934
Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration.
Graham M Wheeler, Michael J Sweeting, +2 authors, Ying Kuen K Cheung.
Stat Med, 2016 Feb 20; 36(2). PMID: 26891942    Free PMC article.
Revisiting Dosing Regimen Using Pharmacokinetic/Pharmacodynamic Mathematical Modeling: Densification and Intensification of Combination Cancer Therapy.
Christophe Meille, Dominique Barbolosi, +2 authors, Athanassios Iliadis.
Clin Pharmacokinet, 2016 Mar 08; 55(8). PMID: 26946136
Adjuvant Dose-Dense Chemotherapy in Breast Cancer: Standard of Care in High-Risk Patients.
Volker Möbus.
Breast Care (Basel), 2016 Apr 07; 11(1). PMID: 27051389    Free PMC article.
Incidence of Febrile Neutropenia in Korean Female Breast Cancer Patients Receiving Preoperative or Postoperative Doxorubicin/Cyclophosphamide Followed by Docetaxel Chemotherapy.
Chang Gon Kim, Joohyuk Sohn, +8 authors, Gun Min Kim.
J Breast Cancer, 2016 Apr 12; 19(1). PMID: 27064666    Free PMC article.
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.
Giampaolo Bianchini, Justin M Balko, +2 authors, Luca Gianni.
Nat Rev Clin Oncol, 2016 Oct 19; 13(11). PMID: 27184417    Free PMC article.
Highly Cited. Review.
Low-Dose Oral Cyclophosphamide and Methotrexate Maintenance for Hormone Receptor-Negative Early Breast Cancer: International Breast Cancer Study Group Trial 22-00.
Marco Colleoni, Kathryn P Gray, +19 authors, Aron Goldhirsch.
J Clin Oncol, 2016 Jun 22; 34(28). PMID: 27325862    Free PMC article.
Systemic therapy for bladder cancer finally comes into a new age.
Matthew Zibelman, Elizabeth R Plimack.
Future Oncol, 2016 Jul 13; 12(19). PMID: 27402371    Free PMC article.
Examining racial variation in antiemetic use and post-chemotherapy health care utilization for nausea and vomiting among breast cancer patients.
Devon K Check, Katherine E Reeder-Hayes, +3 authors, Stacie B Dusetzina.
Support Care Cancer, 2016 Oct 28; 24(12). PMID: 27465051    Free PMC article.
Chemotherapy-induced neutropenia among pediatric cancer patients in Egypt: Risks and consequences.
Mohamed Badr, Tamer Hassan, +5 authors, Sahbaa Fehr.
Mol Clin Oncol, 2016 Sep 03; 5(3). PMID: 27588196    Free PMC article.
Effective combination treatment of lung cancer cells by single vehicular delivery of siRNA and different anticancer drugs.
Jinming Li, Yuanyuan Wang, +5 authors, Zongwan Mao.
Int J Nanomedicine, 2016 Oct 04; 11. PMID: 27695321    Free PMC article.
Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy.
Gabriel Ramirez, Ashley R Proctor, +11 authors, Regine Choe.
Biomed Opt Express, 2016 Oct 05; 7(9). PMID: 27699124    Free PMC article.
A randomized, multi-center, open-label, phase III study of once-per-cycle DA-3031, a pegylated G-CSF, in comparison with daily filgrastim in patients receiving TAC chemotherapy for breast cancer.
K H Park, S Lee, +11 authors, Jae Hong Seo.
Support Care Cancer, 2016 Oct 07; 25(2). PMID: 27709313
Accrual of Older Patients With Breast Cancer to Alliance Systemic Therapy Trials Over Time: Protocol A151527.
Rachel A Freedman, Jared C Foster, +13 authors, Arti Hurria.
J Clin Oncol, 2016 Dec 20; 35(4). PMID: 27992272    Free PMC article.
Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai.
Pan Pantziarka, Lisa Hutchinson, +21 authors, Shripad Banavali.
Ecancermedicalscience, 2016 Dec 21; 10. PMID: 27994645    Free PMC article.
The Impact of the Duration of Adjuvant Chemotherapy on Survival in Patients with Epithelial Ovarian Cancer - A Retrospective Study.
Veronika Seebacher, Alexander Reinthaller, +3 authors, Stephan Polterauer.
PLoS One, 2017 Jan 07; 12(1). PMID: 28060918    Free PMC article.
Phase II Trial of Dose-dense Pemetrexed, Gemcitabine, and Bevacizumab in Patients With Advanced, Non-Small-cell Lung Cancer.
Bryan J Schneider, Gregory P Kalemkerian, +6 authors, Antoinette J Wozniak.
Clin Lung Cancer, 2017 Jan 09; 18(3). PMID: 28063799    Free PMC article.
A Multi-Mitochondrial Anticancer Agent that Selectively Kills Cancer Cells and Overcomes Drug Resistance.
Yong Bo Peng, Zi Long Zhao, +9 authors, Wei Hong Tan.
ChemMedChem, 2017 Jan 18; 12(3). PMID: 28098432    Free PMC article.
Body Composition as a Predictor of Toxicity in Patients Receiving Anthracycline and Taxane-Based Chemotherapy for Early-Stage Breast Cancer.
Shlomit Strulov Shachar, Allison M Deal, +5 authors, Hyman B Muss.
Clin Cancer Res, 2017 Feb 02; 23(14). PMID: 28143874    Free PMC article.
Multidrug resistance transporter-1 and breast cancer resistance protein protect against ovarian toxicity, and are essential in ovarian physiology.
Lynae M Brayboy, Nathalie Oulhen, +3 authors, Gary M Wessel.
Reprod Toxicol, 2017 Feb 22; 69. PMID: 28216407    Free PMC article.
Anthracyclines in Early Breast Cancer: The ABC Trials-USOR 06-090, NSABP B-46-I/USOR 07132, and NSABP B-49 (NRG Oncology).
Joanne L Blum, Patrick J Flynn, +19 authors, Norman Wolmark.
J Clin Oncol, 2017 Apr 12; 35(23). PMID: 28398846    Free PMC article.
Highly Cited.
Timing of paclitaxel treatment in pre-operative or post-operative does not affect survival in breast cancer patients.
Jiayu Wang, Shanshan Chen, +8 authors, Qiao Li.
Thorac Cancer, 2017 Apr 13; 8(3). PMID: 28402606    Free PMC article.
Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, controlled trial.
David Cameron, James P Morden, +22 authors, TACT2 Investigators.
Lancet Oncol, 2017 Jun 11; 18(7). PMID: 28600210    Free PMC article.
Neoadjuvant Therapy for Breast Cancer: Established Concepts and Emerging Strategies.
Tessa G Steenbruggen, Mette S van Ramshorst, +3 authors, Gabe S Sonke.
Drugs, 2017 Jun 16; 77(12). PMID: 28616845
Sequential versus concurrent chemotherapy for adjuvant breast cancer: does dose intensity matter?
N LeVasseur, S K Chia.
Br J Cancer, 2017 Jun 24; 117(2). PMID: 28641309    Free PMC article.
Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.
Tobias Meißner, Adam Mark, +12 authors, Michael Forster.
Cold Spring Harb Mol Case Stud, 2017 Jul 07; 3(4). PMID: 28679691    Free PMC article.
PAM50 gene signatures and breast cancer prognosis with adjuvant anthracycline- and taxane-based chemotherapy: correlative analysis of C9741 (Alliance).
Minetta C Liu, Brandelyn N Pitcher, +20 authors, William T Barry.
NPJ Breast Cancer, 2016 Jan 01; 2. PMID: 28691057    Free PMC article.
Decreased gastrointestinal toxicity associated with a novel capecitabine schedule (7 days on and 7 days off): a systematic review.
Karen A Cadoo, Devika Gajria, +5 authors, Tiffany A Traina.
NPJ Breast Cancer, 2016 Mar 30; 2. PMID: 28721374    Free PMC article.
Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer.
Yuan Yuan, Nilesh Vora, +18 authors, Arti Hurria.
Breast Cancer Res, 2017 Aug 31; 19(1). PMID: 28851415    Free PMC article.
Chemotherapeutic dosing implicated by pharmacodynamic modeling of in vitro cytotoxic data: a case study of paclitaxel.
Hua He, Yanguang Cao.
J Pharmacokinet Pharmacodyn, 2017 Sep 02; 44(5). PMID: 28861682    Free PMC article.
Time trends in utilization of G-CSF prophylaxis and risk of febrile neutropenia in a Medicare population receiving adjuvant chemotherapy for early-stage breast cancer.
Ravi K Goyal, Spiros Tzivelekis, +2 authors, James A Kaye.
Support Care Cancer, 2017 Sep 19; 26(2). PMID: 28921379
Randomized controlled trial of late-course concurrent versus sequential chemoradiotherapy after mastectomy and axillary surgery in locally advanced breast cancer.
Ying Lu, Haixin Huang, Hui Yang, Dagui Chen.
Medicine (Baltimore), 2017 Oct 12; 96(41). PMID: 29019894    Free PMC article.
Tolerability of a rapid-escalation vinblastine-prednisolone protocol in dogs with mast cell tumours.
Juan Carlos Serra Varela, Evi Pecceu, Ian Handel, Jessica Lawrence.
Vet Med Sci, 2017 Oct 27; 2(4). PMID: 29067202    Free PMC article.
Efficacy, safety and proper dose analysis of PEGylated granulocyte colony-stimulating factor as support for dose-dense adjuvant chemotherapy in node positive Chinese breast cancer patients.
Fan Zhang, RuiXia LingHu, +5 authors, Junlan Yang.
Oncotarget, 2017 Nov 08; 8(45). PMID: 29108384    Free PMC article.
Long-term safety and survival outcomes from the Scandinavian Breast Group 2004-1 randomized phase II trial of tailored dose-dense adjuvant chemotherapy for early breast cancer.
Alexios Matikas, Sara Margolin, +12 authors, Jonas Bergh.
Breast Cancer Res Treat, 2017 Dec 01; 168(2). PMID: 29190004    Free PMC article.
Evaluation of Sentinel Lymph Node Biopsy and Axillary Lymph Node Dissection for Breast Cancer Treatment Concepts - a Retrospective Study of 1,214 Breast Cancer Patients.
Roland G Stein, Roland Fricker, +8 authors, Thomas Müller.
Breast Care (Basel), 2017 Dec 14; 12(5). PMID: 29234253    Free PMC article.
Precision Medicine with Imprecise Therapy: Computational Modeling for Chemotherapy in Breast Cancer.
Matthew T McKenna, Jared A Weis, +2 authors, Thomas E Yankeelov.
Transl Oncol, 2018 Apr 21; 11(3). PMID: 29674173    Free PMC article.
Anthracycline Use for Early Stage Breast Cancer in the Modern Era: a Review.
Sakshi Jasra, Jesus Anampa.
Curr Treat Options Oncol, 2018 May 13; 19(6). PMID: 29752560
How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies.
Ji Hyun Park, Jin-Hee Ahn, Sung-Bae Kim.
ESMO Open, 2018 May 17; 3(Suppl 1). PMID: 29765774    Free PMC article.
Phase 2 Study of Dose-Dense Doxorubicin and Cyclophosphamide Followed by Eribulin Mesylate With or Without Prophylactic Growth Factor for Adjuvant Treatment of Early-Stage Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer.
Karen A Cadoo, Peter A Kaufman, +3 authors, Tiffany A Traina.
Clin Breast Cancer, 2018 Jun 14; 18(6). PMID: 29895438    Free PMC article.
Neoadjuvant chemotherapy in breast cancer: a dose-dense schedule in real life and putative role of PIK3CA mutations.
Valentina Cocciolone, Katia Cannita, +16 authors, Corrado Ficorella.
Oncotarget, 2018 Jun 26; 9(44). PMID: 29937992    Free PMC article.
Survival benefit of pure dose-dense chemotherapy in breast cancer: a meta-analysis of randomized controlled trials.
Wenqi Zhou, Shizhe Chen, Faliang Xu, Xiaohua Zeng.
World J Surg Oncol, 2018 Jul 17; 16(1). PMID: 30007402    Free PMC article.
Double-Blind Phase III Trial of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node-Positive and High-Risk Lymph Node-Negative Breast Cancer (E5103).
Kathy D Miller, Anne O'Neill, +12 authors, George W Sledge.
J Clin Oncol, 2018 Jul 25; 36(25). PMID: 30040523    Free PMC article.
Overview of Breast Cancer Therapy.
Tracy-Ann Moo, Rachel Sanford, Chau Dang, Monica Morrow.
PET Clin, 2018 Aug 14; 13(3). PMID: 30100074    Free PMC article.
Clinical outcomes and prognostic factors in patients with stage II-III breast cancer treated with neoadjuvant chemotherapy followed by surgery and postmastectomy radiation therapy in the modern treatment era.
Naomi Nakajima, Masahiko Oguchi, +7 authors, Shinji Ohno.
Adv Radiat Oncol, 2018 Sep 12; 3(3). PMID: 30202796    Free PMC article.
Effectiveness and tolerability of neoadjuvant pertuzumab-containing regimens for HER2-positive localized breast cancer.
Laura Spring, Andrzej Niemierko, +14 authors, Aditya Bardia.
Breast Cancer Res Treat, 2018 Sep 17; 172(3). PMID: 30220055    Free PMC article.
SABCS 2017: update on chemotherapy, targeted therapy, and immunotherapy.
Rupert Bartsch, Elisabeth Bergen.
Memo, 2018 Sep 18; 11(3). PMID: 30220927    Free PMC article.
Randomized study of doxorubicin-based chemotherapy regimens, with and without sildenafil, with analysis of intermediate cardiac markers.
Andrew Poklepovic, Yuesheng Qu, +6 authors, Rakesh C Kukreja.
Cardiooncology, 2018 Sep 18; 4. PMID: 30221011    Free PMC article.
Quality of Breast Cancer Treatment at a Rural Cancer Center in Rwanda.
Daniel S O'Neil, Nancy L Keating, +5 authors, Lydia E Pace.
J Glob Oncol, 2018 Sep 23; 4. PMID: 30241207    Free PMC article.
What Is the Best Management of cN0pN1(sn) Breast Cancer Patients?
Jana de Boniface, Marcus Schmidt, +3 authors, Toralf Reimer.
Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498417    Free PMC article.
Measures of Treatment Workload for Patients With Breast Cancer.
Alex C Cheng, Mia A Levy.
JCO Clin Cancer Inform, 2019 Feb 05; 3. PMID: 30715929    Free PMC article.
Inclusiveness and ethical considerations for observational, translational, and clinical cancer health disparity research.
Michael Behring, Kevin Hale, +3 authors, Upender Manne.
Cancer, 2019 Sep 11; 125(24). PMID: 31502259    Free PMC article.
Cost-utility analysis of 21-gene assay for node-positive early breast cancer.
L Masucci, S Torres, +5 authors, W Isaranuwatchai.
Curr Oncol, 2019 Nov 12; 26(5). PMID: 31708649    Free PMC article.
Prospective Long-Term Follow-Up of Pulmonary Diffusion Capacity Reduction Caused by Dose-Dense Chemotherapy in Patients with Breast Cancer.
Yosef Landman, Salomon Marcello Stemmer, +6 authors, Rinat Yerushalmi.
J Oncol, 2019 Nov 28; 2019. PMID: 31772578    Free PMC article.
Incidence of febrile neutropenia with commonly used chemotherapy regimen in localized breast cancer.
Nageswara Reddy Palukuri, Rajani Priya Yedla, +4 authors, Sadashivudu Gundeti.
South Asian J Cancer, 2020 Jan 21; 9(1). PMID: 31956608    Free PMC article.
Investigation of solid tumor progression with account of proliferation/migration dichotomy via Darwinian mathematical model.
Maxim Kuznetsov, Andrey Kolobov.
J Math Biol, 2019 Oct 03; 80(3). PMID: 31576418
Epidemiology of treatment-associated mucosal injury after treatment with newer regimens for lymphoma, breast, lung, or colorectal cancer.
Jeffrey A Jones, Elenir B C Avritscher, +3 authors, Linda S Elting.
Support Care Cancer, 2006 Apr 08; 14(6). PMID: 16601950
Neoadjuvant Management of Early Breast Cancer: A Clinical and Investigational Position Statement.
Ramon Colomer, Cristina Saura, +7 authors, Ana Lluch.
Oncologist, 2019 Feb 03; 24(5). PMID: 30710068    Free PMC article.
Older-Patient-Specific Cancer Trials: A Pooled Analysis of 2,277 Patients (A151715).
Dyda Dao, Tyler Zemla, +13 authors, Jennifer G Le-Rademacher.
Oncologist, 2019 Apr 13; 24(6). PMID: 30975921    Free PMC article.
Early neutropenia on day 8 treated with adjuvant Docetaxel-based chemotherapy in early breast cancer patients: Putative mechanisms within the neutrophil pool system.
Yoshihiko Furuya.
PLoS One, 2019 Apr 19; 14(4). PMID: 30998754    Free PMC article.
Granulocyte Colony-Stimulating Factor Treatment During Radiotherapy Is Associated With Survival Benefit in Patients With Lung Cancer.
Rui Du, Pingping Hu, +4 authors, Jiandong Zhang.
Technol Cancer Res Treat, 2018 Jan 01; 17. PMID: 31122176    Free PMC article.
Does chemotherapy improve survival in patients with nodal positive luminal A breast cancer? A retrospective Multicenter Study.
Daniel Herr, Manfred Wischnewsky, +10 authors, Achim Wöckel.
PLoS One, 2019 Jul 10; 14(7). PMID: 31283775    Free PMC article.
Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy.
Thashini Moodley, Moganavelli Singh.
Molecules, 2020 Feb 13; 25(3). PMID: 32046364    Free PMC article.
Effects of neoadjuvant chemotherapy on respiratory function in patients with breast cancer.
Lei Ding, Liping Wang, +2 authors, Zijing He.
Chin J Cancer Res, 2020 Mar 21; 32(1). PMID: 32194303    Free PMC article.
Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. the COVID-19 pandemic breast cancer consortium.
Jill R Dietz, Meena S Moran, +16 authors, Katharine A Yao.
Breast Cancer Res Treat, 2020 Apr 26; 181(3). PMID: 32333293    Free PMC article.
Highly Cited.
Updated Survival Analysis after a Median Follow-up of 12 Years of an Anthracycline-Containing Adjuvant Prospective Multicentre, Randomised Phase III Trial on Dose-Dense Chemotherapy in Primary Node-Positive, High-Risk Breast Cancer Patients.
Mattea Reinisch, Oleg Gluz, +10 authors, Sherko Kümmel.
Breast Care (Basel), 2019 Jul 19; 14(3). PMID: 31316314    Free PMC article.
Dose-dense adjuvant chemotherapy in early breast cancer patients: 15-year results of the Phase 3 Mammella InterGruppo (MIG)-1 study.
Eva Blondeaux, Matteo Lambertini, +14 authors, Lucia Del Mastro.
Br J Cancer, 2020 Apr 02; 122(11). PMID: 32231293    Free PMC article.
Clinical Characteristics and Outcome Trends of Adjuvant Anthracycline and Taxane Regimen for Early Stage Breast Cancer.
Ashok K Vaid, Aseem Khurana, +6 authors, Kush Gupta.
World J Oncol, 2020 Jun 05; 11(3). PMID: 32494317    Free PMC article.
Does dose-dense neoadjuvant chemotherapy have clinically significant prognostic value in breast cancer?: A meta-analysis of 3,724 patients.
Yuqin Ding, Kaijing Ding, +3 authors, Xiaowen Ding.
PLoS One, 2020 May 30; 15(5). PMID: 32470093    Free PMC article.
Weathering the Storm: Managing Older Adults With Breast Cancer Amid COVID-19 and Beyond.
Rachel A Freedman, Mina S Sedrak, +8 authors, Eric P Winer.
J Natl Cancer Inst, 2020 May 26; 113(4). PMID: 32449757    Free PMC article.
Multidisciplinary Management of Breast Cancer With Extensive Regional Nodal Involvement.
Benjamin D Smith, Matthew P Goetz, Judy C Boughey.
J Clin Oncol, 2020 May 23; 38(20). PMID: 32442073    Free PMC article.
Cancer systems immunology.
Nathan E Reticker-Flynn, Edgar G Engleman.
Elife, 2020 Jul 14; 9. PMID: 32657757    Free PMC article.
Avoiding Peg-Filgrastim Prophylaxis During the Paclitaxel Portion of the Dose-Dense Doxorubicin-Cyclophosphamide and Paclitaxel Regimen: A Prospective Study.
Ines Vaz-Luis, Romualdo Barroso-Sousa, +18 authors, Nancy U Lin.
J Clin Oncol, 2020 Apr 25; 38(21). PMID: 32330102    Free PMC article.
Clinico-pathologic features, treatment and outcomes of breast cancer during pregnancy or the post-partum period.
Ciara C O'Sullivan, Sheeba Irshad, +6 authors, Karen Lisa Smith.
Breast Cancer Res Treat, 2020 Mar 13; 180(3). PMID: 32162192    Free PMC article.
A Perspective on Expanding Our Understanding of Cancer Treatments by Integrating Approaches from the Biological and Physical Sciences.
Emma J Fong, Carly Strelez, Shannon M Mumenthaler.
SLAS Discov, 2020 Apr 17; 25(7). PMID: 32297829    Free PMC article.
Management of early breast cancer during the COVID-19 pandemic in Brazil.
Francisco Pimentel Cavalcante, Guilherme Garcia Novita, +4 authors, Ruffo Freitas Junior.
Breast Cancer Res Treat, 2020 Aug 18; 184(2). PMID: 32803637    Free PMC article.
Dose-dense TPF induction chemotherapy for locally advanced head and neck cancer: a phase II study.
Ching-Yun Hsieh, Ming-Yuh Lein, +6 authors, Ching-Chan Lin.
BMC Cancer, 2020 Sep 03; 20(1). PMID: 32873270    Free PMC article.
Application of the ESMO-Magnitude of Clinical Benefit Scale (V.1.1) to the field of early breast cancer therapies.
Shani Paluch-Shimon, Nathan I Cherny, +4 authors, Fatima Cardoso.
ESMO Open, 2020 Sep 08; 5(5). PMID: 32893189    Free PMC article.
Dose-dense paclitaxel plus carboplatin vs. epirubicin and cyclophosphamide with paclitaxel as adjuvant chemotherapy for high-risk triple-negative breast cancer.
Qing Li, Jiani Wang, +9 authors, Binghe Xu.
Chin J Cancer Res, 2020 Sep 24; 32(4). PMID: 32963461    Free PMC article.
Adjuvant Dose-Dense Chemotherapy for Breast Cancer: Available Evidence and Recent Updates.
Fernando Kude de Almeida, Daniela Dornelles Rosa.
Breast Care (Basel), 2019 Feb 26; 13(6). PMID: 30800040    Free PMC article.
CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients.
Jemal Hussien Ahmed, Eyasu Makonnen, +8 authors, Eleni Aklillu.
Front Pharmacol, 2019 May 30; 10. PMID: 31139078    Free PMC article.
Pneumocystis jirovecii in a patient on dose-dense chemotherapy for early breast cancer.
Chloe Khoo, Jenny Gilchrist, +2 authors, Richard Kefford.
Respirol Case Rep, 2019 Jul 18; 7(7). PMID: 31312456    Free PMC article.
Big Data Approaches for Modeling Response and Resistance to Cancer Drugs.
Peng Jiang, William R Sellers, X Shirley Liu.
Annu Rev Biomed Data Sci, 2019 Jul 26; 1. PMID: 31342013    Free PMC article.
Social enrichment attenuates chemotherapy induced pro-inflammatory cytokine production and affective behavior via oxytocin signaling.
William H Walker, O Hecmarie Meléndez-Fernández, +2 authors, A Courtney DeVries.
Brain Behav Immun, 2020 Aug 01; 89. PMID: 32735935    Free PMC article.
Management of Breast Cancer During the COVID-19 Pandemic: A Stage- and Subtype-Specific Approach.
Jennifer Y Sheng, Cesar A Santa-Maria, +18 authors, Karen L Smith.
JCO Oncol Pract, 2020 Jul 01; 16(10). PMID: 32603252    Free PMC article.
Newly Synthesized Imino-Derivatives Analogues of Resveratrol Exert Inhibitory Effects in Breast Tumor Cells.
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