Textural analysis of contrast-enhanced MR images of the breast

Peter Gibbs ¹, Lindsay W Turnbull

Affiliations

¹ Academic Department of Radiology, University of Hull, Hull, United Kingdom. p.gibbs@hull.ac.uk

PMID: 12815683
78 citations

Abstract

Texture analysis was applied to high-resolution, contrast-enhanced (CE) images of the breast to provide a method of lesion discrimination. Significant differences were seen between benign and malignant lesions for a number of textural features, including entropy and sum entropy. Using logistic regression analysis (LRA), a diagnostic accuracy of A(z) = 0.80 +/- 0.07 was obtained with a model requiring only three parameters. By initially dividing the patient data into training and test datasets, reasonable model robustness was also established. On combining features obtained using textural analysis with lesion size, time to maximum enhancement, and patient age, a diagnostic accuracy of A(z) = 0.92 +/- 0.05 was demonstrated.

Other Links

Full text on Magnetic resonance in medicine

Cited By

Citedby
Quantitative analysis of lesion morphology and texture features for diagnostic prediction in breast MRI. Ke Nie, Jeon-Hor Chen, +3 authors, Hon J Yu, Yong Chu, Orhan Nalcioglu, Min-Ying Su. less Acad Radiol, 2008 Nov 13; 15(12). PMID: 19000868 Free PMC article.
Non-Hodgkin lymphoma response evaluation with MRI texture classification. Lara C V Harrison, Tiina Luukkaala, +7 authors, Prasun Dastidar. less J Exp Clin Cancer Res, 2009 Jun 24; 28. PMID: 19545438 Free PMC article.
Selection of diagnostic features on breast MRI to differentiate between malignant and benign lesions using computer-aided diagnosis: differences in lesions presenting as mass and non-mass-like enhancement. Dustin Newell, Ke Nie, +4 authors, Min-Ying Su. less Eur Radiol, 2009 Oct 01; 20(4). PMID: 19789878 Free PMC article.
Principal component analysis of breast DCE-MRI adjusted with a model-based method. Erez Eyal, Daria Badikhi, +3 authors, Hadassa Degani. less J Magn Reson Imaging, 2009 Oct 27; 30(5). PMID: 19856419 Free PMC article.
Cancerous breast lesions on dynamic contrast-enhanced MR images: computerized characterization for image-based prognostic markers. Neha Bhooshan, Maryellen L Giger, +3 authors, Sanaz A Jansen, Hui Li, Li Lan, Gillian M Newstead. less Radiology, 2010 Feb 04; 254(3). PMID: 20123903 Free PMC article.
Assessing heterogeneity of lesion enhancement kinetics in dynamic contrast-enhanced MRI for breast cancer diagnosis. A Karahaliou, K Vassiou, +3 authors, L Costaridou. less Br J Radiol, 2010 Mar 26; 83(988). PMID: 20335440 Free PMC article.
Texture analysis of MR images of patients with mild traumatic brain injury. Kirsi K Holli, Lara Harrison, +6 authors, Hannu Eskola. less BMC Med Imaging, 2010 May 14; 10. PMID: 20462439 Free PMC article.
Textural kinetics: a novel dynamic contrast-enhanced (DCE)-MRI feature for breast lesion classification. Shannon C Agner, Salil Soman, +7 authors, Anant Madabhushi. less J Digit Imaging, 2010 May 29; 24(3). PMID: 20508965 Free PMC article.
Computerized assessment of breast lesion malignancy using DCE-MRI robustness study on two independent clinical datasets from two manufacturers. Weijie Chen, Maryellen L Giger, +4 authors, Li Lan. less Acad Radiol, 2010 Jun 15; 17(7). PMID: 20540907 Free PMC article.
Combined use of T2-weighted MRI and T1-weighted dynamic contrast-enhanced MRI in the automated analysis of breast lesions. Neha Bhooshan, Maryellen Giger, +4 authors, Gillian M Newstead. less Magn Reson Med, 2011 Apr 28; 66(2). PMID: 21523818 Free PMC article.
Computerized three-class classification of MRI-based prognostic markers for breast cancer. Neha Bhooshan, Maryellen Giger, +6 authors, Gillian Newstead. less Phys Med Biol, 2011 Aug 24; 56(18). PMID: 21860079 Free PMC article.
Evaluation of texture for classification of abdominal aortic aneurysm after endovascular repair. Guillermo García, Josu Maiora, Arantxa Tapia, Mariano De Blas. J Digit Imaging, 2011 Sep 09; 25(3). PMID: 21901536 Free PMC article.
The recent progress in quantitative medical image analysis for computer aided diagnosis systems. Tae-Yun Kim, Jaebum Son, Kwang-Gi Kim. Healthc Inform Res, 2011 Nov 16; 17(3). PMID: 22084808 Free PMC article.
Germinal center texture entropy as possible indicator of humoral immune response: immunophysiology viewpoint. Igor Pantic, Senka Pantic. Mol Imaging Biol, 2011 Dec 14; 14(5). PMID: 22160876
IMPST: A New Interactive Self-Training Approach to Segmentation Suspicious Lesions in Breast MRI. Reza Azmi, Narges Norozi, +2 authors, Robab Anbiaee, Leila Salehi, Azardokht Amirzadi. less J Med Signals Sens, 2012 May 19; 1(2). PMID: 22606669 Free PMC article.
A New Markov Random Field Segmentation Method for Breast Lesion Segmentation in MR images. Reza Azmi, Narges Norozi. J Med Signals Sens, 2012 May 19; 1(3). PMID: 22606671 Free PMC article.
Radiomics: the process and the challenges. Virendra Kumar, Yuhua Gu, +13 authors, Robert J Gillies. less Magn Reson Imaging, 2012 Aug 18; 30(9). PMID: 22898692 Free PMC article. Highly Cited. Review.
Computerized segmentation and characterization of breast lesions in dynamic contrast-enhanced MR images using fuzzy c-means clustering and snake algorithm. Yachun Pang, Li Li, +3 authors, Wenyong Hu, Yanxia Peng, Lizhi Liu, Yuanzhi Shao. less Comput Math Methods Med, 2012 Sep 07; 2012. PMID: 22952558 Free PMC article.
Assessment of tumor heterogeneity: an emerging imaging tool for clinical practice? Fergus Davnall, Connie S P Yip, +7 authors, Vicky Goh. less Insights Imaging, 2012 Oct 25; 3(6). PMID: 23093486 Free PMC article. Highly Cited.
Assessment of feasibility to use computer aided texture analysis based tool for parametric images of suspicious lesions in DCE-MR mammography. Mehmet Cemil Kale, John David Fleig, Nazım Imal. Comput Math Methods Med, 2013 May 09; 2013. PMID: 23653668 Free PMC article.
Characterization of microcirculation in multiple sclerosis lesions by dynamic texture parameter analysis (DTPA). Rajeev Kumar Verma, Johannes Slotboom, +7 authors, Roland Wiest. less PLoS One, 2013 Jul 23; 8(7). PMID: 23874432 Free PMC article.
Potential of computer-aided diagnosis of high spectral and spatial resolution (HiSS) MRI in the classification of breast lesions. Neha Bhooshan, Maryellen Giger, +7 authors, Gillian Newstead. less J Magn Reson Imaging, 2013 Sep 12; 39(1). PMID: 24023011 Free PMC article.
Computer-aided diagnosis of breast DCE-MRI images using bilateral asymmetry of contrast enhancement between two breasts. Qian Yang, Lihua Li, +3 authors, Bin Zheng. less J Digit Imaging, 2013 Sep 18; 27(1). PMID: 24043592 Free PMC article.
Classification of Small Lesions in Breast MRI: Evaluating The Role of Dynamically Extracted Texture Features Through Feature Selection. Mahesh B Nagarajan, Markus B Huber, +3 authors, Axel Wismüller. less J Med Biol Eng, 2013 Nov 14; 33(1). PMID: 24223533 Free PMC article.
Classification of small lesions in dynamic breast MRI: Eliminating the need for precise lesion segmentation through spatio-temporal analysis of contrast enhancement over time. Mahesh B Nagarajan, Markus B Huber, +3 authors, Axel Wismüller. less Mach Vis Appl, 2013 Nov 19; 24(7). PMID: 24244074 Free PMC article.
Classification of small lesions on dynamic breast MRI: Integrating dimension reduction and out-of-sample extension into CADx methodology. Mahesh B Nagarajan, Markus B Huber, +3 authors, Axel Wismüller. less Artif Intell Med, 2013 Dec 21; 60(1). PMID: 24355697 Free PMC article.
Diagnosis of breast masses from dynamic contrast-enhanced and diffusion-weighted MR: a machine learning approach. Hongmin Cai, Yanxia Peng, +2 authors, Caiwen Ou, Minsheng Chen, Li Li. less PLoS One, 2014 Feb 06; 9(1). PMID: 24498092 Free PMC article.
Relationship between tumor heterogeneity measured on FDG-PET/CT and pathological prognostic factors in invasive breast cancer. Michael Soussan, Fanny Orlhac, +4 authors, Irène Buvat. less PLoS One, 2014 Apr 12; 9(4). PMID: 24722644 Free PMC article. Highly Cited.
Advantages and limitations of anticipating laboratory test results from regression- and tree-based rules derived from electronic health-record data. Fahim Mohammad, Jesse C Theisen-Toupal, Ramy Arnaout. PLoS One, 2014 Apr 16; 9(4). PMID: 24732572 Free PMC article.
A computerized global MR image feature analysis scheme to assist diagnosis of breast cancer: a preliminary assessment. Qian Yang, Lihua Li, +2 authors, Juan Zhang, Guoliang Shao, Bin Zheng. less Eur J Radiol, 2014 Apr 20; 83(7). PMID: 24743001 Free PMC article.
The role of texture analysis in imaging as an outcome predictor and potential tool in radiotherapy treatment planning. S Alobaidli, S McQuaid, +3 authors, C South, V Prakash, P Evans, A Nisbet. less Br J Radiol, 2014 Jul 24; 87(1042). PMID: 25051978 Free PMC article. Review.
Breast density and parenchymal texture measures as potential risk factors for Estrogen-Receptor positive breast cancer. Brad M Keller, Jinbo Chen, Emily F Conant, Despina Kontos. Proc SPIE Int Soc Opt Eng, 2014 Jul 31; 9035. PMID: 25075270 Free PMC article.
Intratumoral heterogeneity of breast cancer xenograft models: texture analysis of diffusion-weighted MR imaging. Bo La Yun, Nariya Cho, +6 authors, Woo Kyung Moon. less Korean J Radiol, 2014 Sep 24; 15(5). PMID: 25246820 Free PMC article.
Quantification of heterogeneity as a biomarker in tumor imaging: a systematic review. Lejla Alic, Wiro J Niessen, Jifke F Veenland. PLoS One, 2014 Oct 21; 9(10). PMID: 25330171 Free PMC article. Systematic Review.
A computer-aided diagnosis system for dynamic contrast-enhanced MR images based on level set segmentation and ReliefF feature selection. Zhiyong Pang, Dongmei Zhu, +2 authors, Dihu Chen, Li Li, Yuanzhi Shao. less Comput Math Methods Med, 2015 Jan 30; 2015. PMID: 25628755 Free PMC article.
IBEX: an open infrastructure software platform to facilitate collaborative work in radiomics. Lifei Zhang, David V Fried, +3 authors, Laurence E Court. less Med Phys, 2015 Mar 05; 42(3). PMID: 25735289 Free PMC article. Highly Cited.
Magnetic resonance imaging texture analysis classification of primary breast cancer. S A Waugh, C A Purdie, +4 authors, A M Thompson. less Eur Radiol, 2015 Jun 13; 26(2). PMID: 26065395
Texture analysis on MR images helps predicting non-response to NAC in breast cancer. N Michoux, S Van den Broeck, +4 authors, I Leconte. less BMC Cancer, 2015 Aug 06; 15. PMID: 26243303 Free PMC article.
Assessment of Invasive Breast Cancer Heterogeneity Using Whole-Tumor Magnetic Resonance Imaging Texture Analysis: Correlations With Detailed Pathological Findings. Eun Sook Ko, Jae-Hun Kim, +3 authors, Seok Jin Nam. less Medicine (Baltimore), 2016 Jan 29; 95(3). PMID: 26817878 Free PMC article.
Role of quantitative computed tomography texture analysis in the differentiation of primary lung cancer and granulomatous nodules. Carole Dennie, Rebecca Thornhill, +4 authors, Donna Maziak. less Quant Imaging Med Surg, 2016 Mar 17; 6(1). PMID: 26981450 Free PMC article.
Radiomics: a new application from established techniques. Vishwa Parekh, Michael A Jacobs. Expert Rev Precis Med Drug Dev, 2017 Jan 04; 1(2). PMID: 28042608 Free PMC article. Highly Cited.
Tensor based multichannel reconstruction for breast tumours identification from DCE-MRIs. X-X Yin, S Hadjiloucas, +3 authors, J-H Chen, Y Zhang, J-L Wu, M-Y Su. less PLoS One, 2017 Mar 11; 12(3). PMID: 28282379 Free PMC article.
Predicting breast cancer response to neoadjuvant chemotherapy using pretreatment diffuse optical spectroscopic texture analysis. William T Tran, Mehrdad J Gangeh, +12 authors, Gregory J Czarnota. less Br J Cancer, 2017 Apr 19; 116(10). PMID: 28419079 Free PMC article.
Interim heterogeneity changes measured using entropy texture features on T2-weighted MRI at 3.0 T are associated with pathological response to neoadjuvant chemotherapy in primary breast cancer. Shelley Henderson, Colin Purdie, +5 authors, Alastair M Thompson. less Eur Radiol, 2017 May 20; 27(11). PMID: 28523352 Free PMC article.
A deep feature fusion methodology for breast cancer diagnosis demonstrated on three imaging modality datasets. Natalia Antropova, Benjamin Q Huynh, Maryellen L Giger. Med Phys, 2017 Jul 07; 44(10). PMID: 28681390 Free PMC article. Highly Cited.
Texture-based classification of different single liver lesion based on SPAIR T2W MRI images. Zhenjiang Li, Yu Mao, +4 authors, Baosheng Li. less BMC Med Imaging, 2017 Jul 15; 17(1). PMID: 28705145 Free PMC article.
A computer-aided diagnosis (CAD) scheme for pretreatment prediction of pathological response to neoadjuvant therapy using dynamic contrast-enhanced MRI texture features. Valentina Giannini, Simone Mazzetti, +3 authors, Laura Martincich. less Br J Radiol, 2017 Jul 15; 90(1077). PMID: 28707546 Free PMC article.
Integrated radiomic framework for breast cancer and tumor biology using advanced machine learning and multiparametric MRI. Vishwa S Parekh, Michael A Jacobs. NPJ Breast Cancer, 2017 Nov 21; 3. PMID: 29152563 Free PMC article.
MRI texture analysis in differentiating luminal A and luminal B breast cancer molecular subtypes - a feasibility study. Kirsi Holli-Helenius, Annukka Salminen, +4 authors, Riitta Parkkola. less BMC Med Imaging, 2017 Dec 30; 17(1). PMID: 29284425 Free PMC article.
Quantitative Morphometry for Osteochondral Tissues Using Second Harmonic Generation Microscopy and Image Texture Information. Takashi Saitou, Hiroshi Kiyomatsu, Takeshi Imamura. Sci Rep, 2018 Feb 13; 8(1). PMID: 29434299 Free PMC article.
MR-based radiomics signature in differentiating ocular adnexal lymphoma from idiopathic orbital inflammation. Jian Guo, Zhenyu Liu, +4 authors, Junfang Xian. less Eur Radiol, 2018 Apr 11; 28(9). PMID: 29632999
Role of quantitative computed tomography texture analysis in the prediction of adherent perinephric fat. Zine-Eddine Khene, Karim Bensalah, +6 authors, Romain Mathieu. less World J Urol, 2018 Apr 21; 36(10). PMID: 29675631
Breast DCE-MRI: lesion classification using dynamic and morphological features by means of a multiple classifier system. Roberta Fusco, Massimiliano Di Marzo, +2 authors, Carlo Sansone, Mario Sansone, Antonella Petrillo. less Eur Radiol Exp, 2017 Jan 01; 1(1). PMID: 29708202 Free PMC article.
Classifying brain metastases by their primary site of origin using a radiomics approach based on texture analysis: a feasibility study. Rafael Ortiz-Ramón, Andrés Larroza, +2 authors, David Moratal. less Eur Radiol, 2018 May 16; 28(11). PMID: 29761357
ALTEA: A Software Tool for the Evaluation of New Biomarkers for Alzheimer's Disease by Means of Textures Analysis on Magnetic Resonance Images. Carlos López-Gómez, Rafael Ortiz-Ramón, +2 authors, Enrique Mollá-Olmos, David Moratal, Alzheimer’s Disease Neuroimaging Initiative. less Diagnostics (Basel), 2018 Jul 22; 8(3). PMID: 30029524 Free PMC article.
Texture Analysis of Dynamic Contrast-Enhanced MRI in Evaluating Pathologic Complete Response (pCR) of Mass-Like Breast Cancer after Neoadjuvant Therapy. Kun Cao, Bo Zhao, +2 authors, Xiao-Ting Li, Yan-Ling Li, Ying-Shi Sun. less J Oncol, 2020 Jan 18; 2019. PMID: 31949430 Free PMC article.
Radiomics based on 18 F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study. Xuejin Ou, Jing Zhang, +4 authors, Xuelei Ma. less Cancer Med, 2019 Nov 27; 9(2). PMID: 31769230 Free PMC article.
Deep Transfer Learning and Radiomics Feature Prediction of Survival of Patients with High-Grade Gliomas. W Han, L Qin, +6 authors, G Young. less AJNR Am J Neuroradiol, 2019 Dec 21; 41(1). PMID: 31857325 Free PMC article.
Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images. Rafael Ortiz-Ramón, Maria Del C Valdés Hernández, +7 authors, David Moratal. less Comput Med Imaging Graph, 2019 Mar 29; 74. PMID: 30921550 Free PMC article.
Ability of 18F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma. Xuejin Ou, Jian Wang, +5 authors, Xuelei Ma. less Contrast Media Mol Imaging, 2019 Apr 02; 2019. PMID: 30930700 Free PMC article.
A Semi-Supervised Method for Tumor Segmentation in Mammogram Images. Hanie Azary, Monireh Abdoos. J Med Signals Sens, 2020 Mar 14; 10(1). PMID: 32166073 Free PMC article.
Role of texture analysis in breast MRI as a cancer biomarker: A review. Rhea D Chitalia, Despina Kontos. J Magn Reson Imaging, 2018 Nov 06; 49(4). PMID: 30390383 Free PMC article. Review.
Radiomics prediction model for the improved diagnosis of clinically significant prostate cancer on biparametric MRI. Mengjuan Li, Tong Chen, +6 authors, Junkang Shen. less Quant Imaging Med Surg, 2020 Mar 20; 10(2). PMID: 32190563 Free PMC article.
Multiparametric radiomics methods for breast cancer tissue characterization using radiological imaging. Vishwa S Parekh, Michael A Jacobs. Breast Cancer Res Treat, 2020 Feb 06; 180(2). PMID: 32020435 Free PMC article.
Differentiation of triple-negative breast cancer from other subtypes through whole-tumor histogram analysis on multiparametric MR imaging. Tianwen Xie, Qiufeng Zhao, +7 authors, Weijun Peng. less Eur Radiol, 2018 Nov 08; 29(5). PMID: 30402704
The Application of Radiomics in Breast MRI: A Review. Dong-Man Ye, Hao-Tian Wang, Tao Yu. Technol Cancer Res Treat, 2020 Apr 30; 19. PMID: 32347167 Free PMC article. Review.
Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features. Wolf-Dieter Vogl, Katja Pinker, +7 authors, Georg Langs. less Eur Radiol Exp, 2019 Apr 29; 3(1). PMID: 31030291 Free PMC article.
Radiomics in Breast Imaging from Techniques to Clinical Applications: A Review. Seung Hak Lee, Hyunjin Park, Eun Sook Ko. Korean J Radiol, 2020 Jun 12; 21(7). PMID: 32524780 Free PMC article. Review.
Radiomics: from qualitative to quantitative imaging. William Rogers, Sithin Thulasi Seetha, +14 authors, Philippe Lambin. less Br J Radiol, 2020 Feb 27; 93(1108). PMID: 32101448 Free PMC article. Review.
Glioblastoma and Anaplastic Astrocytoma: Differentiation Using MRI Texture Analysis. Zerong Tian, Chaoyue Chen, +4 authors, Jianguo Xu. less Front Oncol, 2019 Sep 26; 9. PMID: 31552189 Free PMC article.
Pharmacokinetic parameters and radiomics model based on dynamic contrast enhanced MRI for the preoperative prediction of sentinel lymph node metastasis in breast cancer. Meijie Liu, Ning Mao, +7 authors, Haizhu Xie. less Cancer Imaging, 2020 Sep 17; 20(1). PMID: 32933585 Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay. Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff. less Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569 Free PMC article.
Prediction of Cervical Lymph Node Metastasis Using MRI Radiomics Approach in Papillary Thyroid Carcinoma: A Feasibility Study. Heng Zhang, Shudong Hu, +6 authors, Shaofeng Duan. less Technol Cancer Res Treat, 2020 Nov 10; 19. PMID: 33161833 Free PMC article.
Impact of different scanners and acquisition parameters on robustness of MR radiomics features based on women's cervix. Honglan Mi, Mingyuan Yuan, +4 authors, Qing Lu. less Sci Rep, 2020 Nov 25; 10(1). PMID: 33230228 Free PMC article.
Pattern identification of biomedical images with time series: Contrasting THz pulse imaging with DCE-MRIs. Xiao-Xia Yin, Sillas Hadjiloucas, +3 authors, Derek Abbott. less Artif Intell Med, 2016 Mar 10; 67. PMID: 26951630 Free PMC article.
[Radiomics: Big Data Instead of Biopsies in the Future?] Kathrin Scheckenbach. Laryngorhinootologie, 2018 Jun 16; 97(S 01). PMID: 29905355 Free PMC article. Review.
Spatial Bayesian modeling of GLCM with application to malignant lesion characterization. Xiao Li, Michele Guindani, Chaan S Ng, Brian P Hobbs. J Appl Stat, 2018 Jan 01; 46(2). PMID: 31439980 Free PMC article.
Radiomics Nomogram of DCE-MRI for the Prediction of Axillary Lymph Node Metastasis in Breast Cancer. Ning Mao, Yi Dai, +5 authors, Nan Hong. less Front Oncol, 2021 Jan 01; 10. PMID: 33381444 Free PMC article.

BioKDE: Biomedical Knowledge Discovery Engine

Abstract

Other Links