Journal Article
. 2003 Aug; 198(4):569-80.
doi: 10.1084/jem.20030590.

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells

Willem W Overwijk 1 Marc R Theoret  Steven E Finkelstein  Deborah R Surman  Laurina A de Jong  Florry A Vyth-Dreese  Trees A Dellemijn  Paul A Antony  Paul J Spiess  Douglas C Palmer  David M Heimann  Christopher A Klebanoff  Zhiya Yu  Leroy N Hwang  Lionel Feigenbaum  Ada M Kruisbeek  Steven A Rosenberg  Nicholas P Restifo  
Affiliations
  • PMID: 12925674
  •     50 References
  •     463 citations

Abstract

Many tumor-associated antigens are derived from nonmutated "self" proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo with vaccination. These T cells exist in a functionally tolerant state, as they rarely result in tumor eradication. We found that tumor growth and lethality were unchanged in mice even after adoptive transfer of large numbers of T cells specific for an MHC class I-restricted epitope of the self/tumor antigen gp100. We sought to develop new strategies that would reverse the functionally tolerant state of self/tumor antigen-reactive T cells and enable the destruction of large (with products of perpendicular diameters of >50 mm2), subcutaneous, unmanipulated, poorly immunogenic B16 tumors that were established for up to 14 d before the start of treatment. We have defined three elements that are all strictly necessary to induce tumor regression in this model: (a) adoptive transfer of tumor-specific T cells; (b) T cell stimulation through antigen-specific vaccination with an altered peptide ligand, rather than the native self-peptide; and (c) coadministration of a T cell growth and activation factor. Cells, vaccination, or cyto-kine given alone or any two in combination were insufficient to induce tumor destruction. Autoimmune vitiligo was observed in mice cured of their disease. These findings illustrate that adoptive transfer of T cells and IL-2 can augment the function of a cancer vaccine. Furthermore, these data represent the first demonstration of complete cures of large, established, poorly immunogenic, unmanipulated solid tumors using T cells specific for a true self/tumor antigen and form the basis for a new approach to the treatment of patients with cancer.

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Gavin M Bendle, Shao-An Xue, Angelika Holler, Hans J Stauss.
PLoS One, 2007 Apr 05; 2(4). PMID: 17406677    Free PMC article.
Maximizing CD8+ T cell responses elicited by peptide vaccines containing CpG oligodeoxynucleotides.
James N Kochenderfer, Christopher D Chien, Jessica L Simpson, Ronald E Gress.
Clin Immunol, 2007 Jun 23; 124(2). PMID: 17584532    Free PMC article.
Induction of postsurgical tumor immunity and T-cell memory by a poorly immunogenic tumor.
Peisheng Zhang, Anik L Côté, +2 authors, Mary Jo Turk.
Cancer Res, 2007 Jul 10; 67(13). PMID: 17616708    Free PMC article.
CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
Dolgor Baatar, Purevdorj Olkhanud, +2 authors, Arya Biragyn.
J Immunol, 2007 Jul 21; 179(3). PMID: 17641067    Free PMC article.
Mobilizing the low-avidity T cell repertoire to kill tumors.
Rachel H McMahan, Jill E Slansky.
Semin Cancer Biol, 2007 Jul 27; 17(4). PMID: 17651986    Free PMC article.
Review.
Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model.
C Marcela Díaz-Montero, Sabry El Naggar, +4 authors, Mohamed L Salem.
Cancer Immunol Immunother, 2007 Aug 30; 57(4). PMID: 17726606    Free PMC article.
Rapid maturation of effector T cells in tumors, but not lymphoid organs, during tumor regression.
Lyse A Norian, Paul M Allen.
PLoS One, 2007 Sep 06; 2(9). PMID: 17786193    Free PMC article.
Toll-like receptors in tumor immunotherapy.
Chrystal M Paulos, Andrew Kaiser, +11 authors, Nicholas P Restifo.
Clin Cancer Res, 2007 Sep 19; 13(18 Pt 1). PMID: 17875756    Free PMC article.
Review.
4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy.
Hua Zhang, Kristen M Snyder, +4 authors, Crystal L Mackall.
J Immunol, 2007 Sep 20; 179(7). PMID: 17878391    Free PMC article.
T-cell receptor gene therapy of established tumors in a murine melanoma model.
John D Abad, Claudia Wrzensinski, +12 authors, Richard A Morgan.
J Immunother, 2007 Dec 25; 31(1). PMID: 18157006    Free PMC article.
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain.
Robert M Prins, Chengyi J Shu, +9 authors, Linda M Liau.
Cancer Immunol Immunother, 2008 Feb 07; 57(9). PMID: 18253732    Free PMC article.
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.
Christian S Hinrichs, Rosanne Spolski, +7 authors, Nicholas P Restifo.
Blood, 2008 Feb 16; 111(11). PMID: 18276844    Free PMC article.
Highly Cited.
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Pawel Muranski, Andrea Boni, +14 authors, Nicholas P Restifo.
Blood, 2008 Mar 21; 112(2). PMID: 18354038    Free PMC article.
Highly Cited.
Adoptive cell transfer: a clinical path to effective cancer immunotherapy.
Steven A Rosenberg, Nicholas P Restifo, +2 authors, Mark E Dudley.
Nat Rev Cancer, 2008 Mar 21; 8(4). PMID: 18354418    Free PMC article.
Highly Cited. Review.
Signaling defects in anti-tumor T cells.
Alan B Frey, Ngozi Monu.
Immunol Rev, 2008 Mar 28; 222. PMID: 18364003    Free PMC article.
Review.
Recombinant lentivector as a genetic immunization vehicle for antitumor immunity.
Yukai He, David Munn, Louis D Falo.
Expert Rev Vaccines, 2008 Apr 02; 6(6). PMID: 18377355    Free PMC article.
Review.
The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells.
Heather J Symons, Moshe Y Levy, +6 authors, Ephraim J Fuchs.
Biol Blood Marrow Transplant, 2008 Apr 16; 14(5). PMID: 18410892    Free PMC article.
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.
Bianca Heemskerk, Ke Liu, +9 authors, Steven A Rosenberg.
Hum Gene Ther, 2008 May 01; 19(5). PMID: 18444786    Free PMC article.
Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition.
S Yang, C J Cohen, +8 authors, R A Morgan.
Gene Ther, 2008 May 23; 15(21). PMID: 18496571    Free PMC article.
Targeting tumors with LIGHT to generate metastasis-clearing immunity.
Ping Yu, Yang-Xin Fu.
Cytokine Growth Factor Rev, 2008 May 30; 19(3-4). PMID: 18508404    Free PMC article.
Review.
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.
Douglas C Palmer, Chi-Chao Chan, +11 authors, Nicholas P Restifo.
Proc Natl Acad Sci U S A, 2008 Jun 05; 105(23). PMID: 18523011    Free PMC article.
Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog.
Caius G Radu, Chengyi J Shu, +5 authors, Owen N Witte.
Nat Med, 2008 Jun 11; 14(7). PMID: 18542051    Free PMC article.
In vivo functional efficacy of tumor-specific T cells expanded using HLA-Ig based artificial antigen presenting cells (aAPC).
Malarvizhi Durai, Christine Krueger, +4 authors, Jonathan P Schneck.
Cancer Immunol Immunother, 2008 Jun 20; 58(2). PMID: 18563409    Free PMC article.
Defective MHC class II presentation by dendritic cells limits CD4 T cell help for antitumor CD8 T cell responses.
Michael Y Gerner, Kerry A Casey, Matthew F Mescher.
J Immunol, 2008 Jun 21; 181(1). PMID: 18566380    Free PMC article.
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells.
Satoko Matsumura, Baomei Wang, +8 authors, Sandra Demaria.
J Immunol, 2008 Aug 21; 181(5). PMID: 18713980    Free PMC article.
Highly Cited.
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.
Sergio A Quezada, Karl S Peggs, +3 authors, James P Allison.
J Exp Med, 2008 Aug 30; 205(9). PMID: 18725522    Free PMC article.
Highly Cited.
Overcoming obstacles to the effective immunotherapy of human cancer.
Steven A Rosenberg.
Proc Natl Acad Sci U S A, 2008 Aug 30; 105(35). PMID: 18753635    Free PMC article.
Efficient cross-presentation depends on autophagy in tumor cells.
Yuhuan Li, Li-Xin Wang, +3 authors, Hong-Ming Hu.
Cancer Res, 2008 Sep 02; 68(17). PMID: 18757401    Free PMC article.
Highly Cited.
Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.
Andrea Boni, Pawel Muranski, +8 authors, Nicholas P Restifo.
Blood, 2008 Sep 19; 112(12). PMID: 18799724    Free PMC article.
Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.
Chengyi J Shu, Caius G Radu, +5 authors, Owen N Witte.
Int Immunol, 2008 Dec 25; 21(2). PMID: 19106231    Free PMC article.
Infection-mimicking materials to program dendritic cells in situ.
Omar A Ali, Nathaniel Huebsch, +2 authors, David J Mooney.
Nat Mater, 2009 Jan 13; 8(2). PMID: 19136947    Free PMC article.
Highly Cited.
Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy.
Prakash Thapa, Guodong Zhang, +10 authors, Dapeng Zhou.
Vaccine, 2009 Feb 10; 27(25-26). PMID: 19200815    Free PMC article.
Melanoma progression despite infiltration by in vivo-primed TRP-2-specific T cells.
Vinod Singh, Qingyong Ji, +2 authors, Arthur A Hurwitz.
J Immunother, 2009 Feb 25; 32(2). PMID: 19238011    Free PMC article.
Adoptive immunotherapy of cancer using CD4(+) T cells.
Pawel Muranski, Nicholas P Restifo.
Curr Opin Immunol, 2009 Mar 17; 21(2). PMID: 19285848    Free PMC article.
Highly Cited. Review.
Adoptive cell therapy for the treatment of patients with metastatic melanoma.
Steven A Rosenberg, Mark E Dudley.
Curr Opin Immunol, 2009 Mar 24; 21(2). PMID: 19304471    Free PMC article.
Highly Cited. Review.
TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression.
Maria Giovanna di Bari, M E Christine Lutsiak, +6 authors, Helen Sabzevari.
Cancer Immunol Immunother, 2009 Mar 26; 58(11). PMID: 19319531    Free PMC article.
Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.
Gabrielle A Rizzuto, Taha Merghoub, +9 authors, Alan N Houghton.
J Exp Med, 2009 Apr 01; 206(4). PMID: 19332877    Free PMC article.
Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.
Huanfa Yi, Xiaofei Yu, +6 authors, Xiang-Yang Wang.
Blood, 2009 Apr 08; 113(23). PMID: 19349620    Free PMC article.
Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma.
Steven Yeh, Neel K Karne, +12 authors, Robert B Nussenblatt.
Ophthalmology, 2009 May 05; 116(5). PMID: 19410956    Free PMC article.
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.
Daniel Hirschhorn-Cymerman, Gabrielle A Rizzuto, +6 authors, Alan N Houghton.
J Exp Med, 2009 May 06; 206(5). PMID: 19414558    Free PMC article.
Lentivector immunization stimulates potent CD8 T cell responses against melanoma self-antigen tyrosinase-related protein 1 and generates antitumor immunity in mice.
Yanjun Liu, Yibing Peng, +4 authors, Yukai He.
J Immunol, 2009 May 06; 182(10). PMID: 19414747    Free PMC article.
Functions of γC cytokines in immune homeostasis: current and potential clinical applications.
Willem W Overwijk, Kimberly S Schluns.
Clin Immunol, 2009 May 12; 132(2). PMID: 19428306    Free PMC article.
Review.
Type 17 CD8+ T cells display enhanced antitumor immunity.
Christian S Hinrichs, Andrew Kaiser, +7 authors, Nicholas P Restifo.
Blood, 2009 May 28; 114(3). PMID: 19471017    Free PMC article.
IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.
Andrew G Sikora, Nina Jaffarzad, +9 authors, Willem W Overwijk.
J Immunol, 2009 Jun 06; 182(12). PMID: 19494262    Free PMC article.
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.
Aaron P Rapoport, Edward A Stadtmauer, +22 authors, Carl H June.
Clin Cancer Res, 2009 Jun 11; 15(13). PMID: 19509133    Free PMC article.
Tregs utilize beta-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their TCR-mediated ERK activity and proliferation.
Dolgor Baatar, Purevdorj B Olkhanud, +3 authors, Arya Biragyn.
Brain Behav Immun, 2009 Jun 13; 23(7). PMID: 19520156    Free PMC article.
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.
Luca Gattinoni, Xiao-Song Zhong, +10 authors, Nicholas P Restifo.
Nat Med, 2009 Jun 16; 15(7). PMID: 19525962    Free PMC article.
Highly Cited.
Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.
Christopher A Klebanoff, Zhiya Yu, +3 authors, Nicholas P Restifo.
Blood, 2009 Jun 30; 114(9). PMID: 19561320    Free PMC article.
High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.
Andrew G Brandmaier, Wolfgang W Leitner, +3 authors, Christopher E Touloukian.
J Immunother, 2009 Jun 30; 32(7). PMID: 19561540    Free PMC article.
CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion.
Yolanda Nesbeth, Uciane Scarlett, +4 authors, Jose R Conejo-Garcia.
Cancer Res, 2009 Jul 16; 69(15). PMID: 19602595    Free PMC article.
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
K S Peggs, S A Quezada, J P Allison.
Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765    Free PMC article.
Review.
Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts.
Yongzhi Cui, Hua Zhang, +3 authors, Crystal L Mackall.
Blood, 2009 Aug 26; 114(18). PMID: 19704119    Free PMC article.
Quantitating T cell cross-reactivity for unrelated peptide antigens.
Jeffrey Ishizuka, Kristie Grebe, +14 authors, Jonathan W Yewdell.
J Immunol, 2009 Sep 08; 183(7). PMID: 19734234    Free PMC article.
Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma.
Franz O Smith, Jacob A Klapper, +2 authors, Mark E Dudley.
J Immunother, 2009 Sep 16; 32(8). PMID: 19752747    Free PMC article.
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.
Christian S Hinrichs, Zachary A Borman, +14 authors, Nicholas P Restifo.
Proc Natl Acad Sci U S A, 2009 Oct 07; 106(41). PMID: 19805141    Free PMC article.
Highly Cited.
Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects.
Hyun-Il Cho, Esteban Celis.
Cancer Res, 2009 Nov 12; 69(23). PMID: 19903852    Free PMC article.
Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination.
Mohamed Labib Salem, David J Cole.
Cancer Immunol Immunother, 2009 Nov 19; 59(3). PMID: 19921513    Free PMC article.
Review.
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.
Claudia Wrzesinski, Chrystal M Paulos, +6 authors, Nicholas P Restifo.
J Immunother, 2009 Dec 03; 33(1). PMID: 19952961    Free PMC article.
Highly Cited.
Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs.
Takeshi Nakahara, Hiroshi Uchi, +7 authors, Alan N Houghton.
Blood, 2010 Feb 16; 115(22). PMID: 20154220    Free PMC article.
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
Sergio A Quezada, Tyler R Simpson, +9 authors, James P Allison.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156971    Free PMC article.
Highly Cited.
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
Ying Xie, Akgül Akpinarli, +6 authors, Paul Andrew Antony.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156973    Free PMC article.
Highly Cited.
B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice.
David J DiLillo, Koichi Yanaba, Thomas F Tedder.
J Immunol, 2010 Mar 03; 184(7). PMID: 20194720    Free PMC article.
Highly Cited.
Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation.
Scott E James, Philip D Greenberg, +7 authors, Oliver W Press.
J Immunol, 2010 Mar 12; 184(8). PMID: 20220093    Free PMC article.
In situ regulation of DC subsets and T cells mediates tumor regression in mice.
Omar A Ali, Dwaine Emerich, Glenn Dranoff, David J Mooney.
Sci Transl Med, 2010 Apr 07; 1(8). PMID: 20368186    Free PMC article.
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.
Gavin M Bendle, Carsten Linnemann, +11 authors, Ton N M Schumacher.
Nat Med, 2010 Apr 20; 16(5). PMID: 20400962
Highly Cited.
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.
Adam D Cohen, David A Schaer, +10 authors, Jedd D Wolchok.
PLoS One, 2010 May 11; 5(5). PMID: 20454651    Free PMC article.
Highly Cited.
Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay.
Fernando Pastor, Despina Kolonias, Paloma H Giangrande, Eli Gilboa.
Nature, 2010 May 14; 465(7295). PMID: 20463739    Free PMC article.
Highly Cited.
DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells.
Mizuki Tomihari, Jin-Sung Chung, +2 authors, Kiyoshi Ariizumi.
Cancer Res, 2010 Jun 24; 70(14). PMID: 20570888    Free PMC article.
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer.
Rajeev K Shrimali, Zhiya Yu, +3 authors, Steven A Rosenberg.
Cancer Res, 2010 Jul 16; 70(15). PMID: 20631075    Free PMC article.
Highly Cited.
Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects.
Myriam N Bouchlaka, Doug Redelman, William J Murphy.
Immunotherapy, 2010 Jul 20; 2(3). PMID: 20635904    Free PMC article.
Review.
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.
Sid P Kerkar, Pawel Muranski, +12 authors, Nicholas P Restifo.
Cancer Res, 2010 Jul 22; 70(17). PMID: 20647327    Free PMC article.
Highly Cited.
Covalent crosslinking of tumor antigens stimulates an antitumor immune response.
Yanping Wang, Xiang-Yang Wang, John R Subjeck, Hyung L Kim.
Vaccine, 2010 Aug 05; 28(40). PMID: 20682362    Free PMC article.
Artificial antigen-presenting cells for use in adoptive immunotherapy.
Cameron J Turtle, Stanley R Riddell.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693850    Free PMC article.
Review.
Superior efficacy of tumor cell vaccines grown in physiologic oxygen.
Michael R Olin, Brian M Andersen, +9 authors, John R Ohlfest.
Clin Cancer Res, 2010 Sep 23; 16(19). PMID: 20858839    Free PMC article.
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment.
Cesar A Corzo, Thomas Condamine, +10 authors, Dmitry I Gabrilovich.
J Exp Med, 2010 Sep 30; 207(11). PMID: 20876310    Free PMC article.
Highly Cited.
Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses.
Weiyi Peng, Yang Ye, +8 authors, Patrick Hwu.
Clin Cancer Res, 2010 Oct 05; 16(22). PMID: 20889916    Free PMC article.
Interferon γ limits the effectiveness of melanoma peptide vaccines.
Hyun-Il Cho, Young-Ran Lee, Esteban Celis.
Blood, 2010 Oct 05; 117(1). PMID: 20889921    Free PMC article.
Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization.
Qifeng Zhou, Haiyan Xiao, +8 authors, Yukai He.
J Immunol, 2010 Oct 12; 185(9). PMID: 20926790    Free PMC article.
Overview of cellular immunotherapy for patients with glioblastoma.
Elodie Vauleon, Tony Avril, +2 authors, Véronique Quillien.
Clin Dev Immunol, 2010 Oct 19; 2010. PMID: 20953324    Free PMC article.
Review.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.
Christian S Hinrichs, Zachary A Borman, +14 authors, Nicholas P Restifo.
Blood, 2010 Oct 26; 117(3). PMID: 20971955    Free PMC article.
Highly Cited.
Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice.
Dhanalakshmi Chinnasamy, Zhiya Yu, +6 authors, Steven A Rosenberg.
J Clin Invest, 2010 Oct 28; 120(11). PMID: 20978347    Free PMC article.
Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.
Sung P Ha, Nicholas D Klemen, +8 authors, Christopher E Touloukian.
J Clin Invest, 2010 Nov 19; 120(12). PMID: 21084750    Free PMC article.
Adoptive cell therapy of prostate cancer using female mice-derived T cells that react with prostate antigens.
Huanfa Yi, Xiaofei Yu, +3 authors, Xiang-Yang Wang.
Cancer Immunol Immunother, 2010 Nov 23; 60(3). PMID: 21088965    Free PMC article.
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.
Madhav D Sharma, De-Yan Hou, +6 authors, David H Munn.
Immunity, 2010 Dec 15; 33(6). PMID: 21145762    Free PMC article.
Highly Cited.
A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.
Nachimuthu Chinnasamy, Jennifer A Wargo, +11 authors, Richard A Morgan.
J Immunol, 2010 Dec 15; 186(2). PMID: 21149604    Free PMC article.
Genetic modification of T cells.
Chiara Bonini, Malcolm K Brenner, Helen E Heslop, Richard A Morgan.
Biol Blood Marrow Transplant, 2011 Jan 14; 17(1 Suppl). PMID: 21195304    Free PMC article.
Review.
EGFR-homing dsRNA activates cancer-targeted immune response and eliminates disseminated EGFR-overexpressing tumors in mice.
Alexei Shir, Manfred Ogris, +2 authors, Alexander Levitzki.
Clin Cancer Res, 2011 Jan 05; 17(5). PMID: 21196415    Free PMC article.
Therapeutic cancer vaccines: are we there yet?
Christopher A Klebanoff, Nicolas Acquavella, Zhiya Yu, Nicholas P Restifo.
Immunol Rev, 2011 Jan 05; 239(1). PMID: 21198663    Free PMC article.
Highly Cited. Review.
Immunization delivered by lentiviral vectors for cancer and infectious diseases.
Biliang Hu, April Tai, Pin Wang.
Immunol Rev, 2011 Jan 05; 239(1). PMID: 21198664    Free PMC article.
Review.
Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment.
Ling Zhang, Sid P Kerkar, +5 authors, Richard A Morgan.
Mol Ther, 2011 Feb 03; 19(4). PMID: 21285960    Free PMC article.
Highly Cited.
Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice.
Sally M Amos, Hollie J Pegram, +7 authors, Michael H Kershaw.
Cancer Immunol Immunother, 2011 Feb 18; 60(5). PMID: 21327636    Free PMC article.
Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease.
Yukihiro Horie, Wataru Saito, +3 authors, Shigeaki Ohno.
Jpn J Ophthalmol, 2011 Feb 19; 55(1). PMID: 21331694
Activating systemic T-cell immunity against self tumor antigens to support oncolytic virotherapy with vesicular stomatitis virus.
Phonphimon Wongthida, Rosa Maria Diaz, +7 authors, Richard Vile.
Hum Gene Ther, 2011 Mar 04; 22(11). PMID: 21366404    Free PMC article.
Antitumor activity mediated by CpG: the route of administration is critical.
Yanyan Lou, Chengwen Liu, +9 authors, Patrick Hwu.
J Immunother, 2011 Mar 11; 34(3). PMID: 21389870    Free PMC article.
Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients.
Steven E Finkelstein, Cristina Iclozan, +15 authors, Dmitry I Gabrilovich.
Int J Radiat Oncol Biol Phys, 2011 Mar 15; 82(2). PMID: 21398051    Free PMC article.
Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model.
Dominique N Lisiero, Horacio Soto, Linda M Liau, Robert M Prins.
J Immunol, 2011 Mar 25; 186(9). PMID: 21430221    Free PMC article.
Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.
Sid P Kerkar, Luis Sanchez-Perez, +12 authors, Nicholas P Restifo.
J Immunother, 2011 Apr 19; 34(4). PMID: 21499127    Free PMC article.
Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma.
Katelyn T Byrne, Anik L Côté, +7 authors, Mary Jo Turk.
J Clin Invest, 2011 May 05; 121(5). PMID: 21540555    Free PMC article.
Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors.
Timothy Kottke, Fiona Errington, +12 authors, Richard Vile.
Nat Med, 2011 Jun 21; 17(7). PMID: 21685898    Free PMC article.
Systemic therapy in hepatocellular carcinoma.
Stephen H Wrzesinski, Tamar H Taddei, Mario Strazzabosco.
Clin Liver Dis, 2011 Jun 22; 15(2). PMID: 21689622    Free PMC article.
Review.
Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope.
David A Schaer, Yongbiao Li, +8 authors, Jedd D Wolchok.
PLoS One, 2011 Jul 07; 6(6). PMID: 21731676    Free PMC article.
Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice.
Christopher A Klebanoff, Luca Gattinoni, +9 authors, Nicholas P Restifo.
Clin Cancer Res, 2011 Jul 09; 17(16). PMID: 21737507    Free PMC article.
Highly Cited.
Anti-tumor effects of endogenous prostate cancer-specific CD8 T cells in a murine TCR transgenic model.
Tullia C Bruno, Cristin Rothwell, +6 authors, Charles G Drake.
Prostate, 2011 Jul 16; 72(5). PMID: 21761425    Free PMC article.
Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers.
Fernando Pastor, Despina Kolonias, James O McNamara, Eli Gilboa.
Mol Ther, 2011 Aug 11; 19(10). PMID: 21829171    Free PMC article.
CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma.
Jie Qian, Huanfa Yi, +7 authors, Xiang-Yang Wang.
J Immunol, 2011 Aug 13; 187(6). PMID: 21832164    Free PMC article.
Engineered T cells for the adoptive therapy of B-cell chronic lymphocytic leukaemia.
Philipp Koehler, Patrick Schmidt, +2 authors, Hinrich Abken.
Adv Hematol, 2011 Aug 13; 2012. PMID: 21837241    Free PMC article.
Natural splice variant of MHC class I cytoplasmic tail enhances dendritic cell-induced CD8+ T-cell responses and boosts anti-tumor immunity.
Tania G Rodríguez-Cruz, Shujuan Liu, +4 authors, Gregory Lizée.
PLoS One, 2011 Aug 24; 6(8). PMID: 21860662    Free PMC article.
IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells.
Qianting Yang, Gang Li, +7 authors, Binfeng Lu.
Eur J Immunol, 2011 Sep 03; 41(11). PMID: 21887788    Free PMC article.
New perspectives on the role of vitiligo in immune responses to melanoma.
Katelyn T Byrne, Mary Jo Turk.
Oncotarget, 2011 Sep 14; 2(9). PMID: 21911918    Free PMC article.
Review.
Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.
Tangying Lu, Rupal Ramakrishnan, +7 authors, Dmitry Gabrilovich.
J Clin Invest, 2011 Sep 14; 121(10). PMID: 21911941    Free PMC article.
Highly Cited.
Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity.
Huanfa Yi, Chunqing Guo, +7 authors, Xiang-Yang Wang.
Cancer Res, 2011 Sep 15; 71(21). PMID: 21914786    Free PMC article.
Synergy of brief activation of CD8 T-cells in the presence of IL-12 and adoptive transfer into lymphopenic hosts promotes tumor clearance and anti-tumor memory.
C Marcela Díaz-Montero, Osama Naga, +9 authors, Mathias G Lichtenheld.
Am J Cancer Res, 2011 Sep 15; 1(7). PMID: 21915391    Free PMC article.
Adoptive T cell therapy promotes the emergence of genomically altered tumor escape variants.
Karen M Kaluza, Jill M Thompson, +3 authors, Richard G Vile.
Int J Cancer, 2011 Sep 22; 131(4). PMID: 21935923    Free PMC article.
HSP70i is a critical component of the immune response leading to vitiligo.
Jeffrey A Mosenson, Andrew Zloza, +3 authors, I Caroline Le Poole.
Pigment Cell Melanoma Res, 2011 Oct 08; 25(1). PMID: 21978301    Free PMC article.
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.
Anik L Côté, Katelyn T Byrne, +2 authors, Mary Jo Turk.
PLoS One, 2011 Nov 03; 6(10). PMID: 22046294    Free PMC article.
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.
Sid P Kerkar, Romina S Goldszmid, +10 authors, Nicholas P Restifo.
J Clin Invest, 2011 Nov 08; 121(12). PMID: 22056381    Free PMC article.
Highly Cited.
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells.
Yun Ji, Zoltan Pos, +12 authors, Luca Gattinoni.
Nat Immunol, 2011 Nov 08; 12(12). PMID: 22057288    Free PMC article.
Targeting and utilizing primary tumors as live vaccines: changing strategies.
Xuanming Yang, Eric D Mortenson, Yang-Xin Fu.
Cell Mol Immunol, 2011 Nov 22; 9(1). PMID: 22101245    Free PMC article.
Review.
Experimental mouse tumour models: what can be learnt about human cancer immunology?
Glenn Dranoff.
Nat Rev Immunol, 2011 Dec 03; 12(1). PMID: 22134155
Review.
New immune therapy targets tumor-associated environment: from bone marrow to tumor site.
Yang-Xin Fu.
Cell Mol Immunol, 2011 Dec 14; 9(1). PMID: 22157624    Free PMC article.
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
James N Kochenderfer, Mark E Dudley, +15 authors, Steven A Rosenberg.
Blood, 2011 Dec 14; 119(12). PMID: 22160384    Free PMC article.
Highly Cited.
The confluence of stereotactic ablative radiotherapy and tumor immunology.
Steven Eric Finkelstein, Robert Timmerman, +4 authors, George D Wilson.
Clin Dev Immunol, 2011 Dec 14; 2011. PMID: 22162711    Free PMC article.
Review.
Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment.
Alexander M Lesokhin, Tobias M Hohl, +9 authors, Jedd D Wolchok.
Cancer Res, 2011 Dec 17; 72(4). PMID: 22174368    Free PMC article.
Highly Cited.
Th17 cells are long lived and retain a stem cell-like molecular signature.
Pawel Muranski, Zachary A Borman, +19 authors, Nicholas P Restifo.
Immunity, 2011 Dec 20; 35(6). PMID: 22177921    Free PMC article.
Highly Cited.
Characterization of T-cell memory phenotype after in vitro expansion of tumor-infiltrating lymphocytes from melanoma patients.
Juhua Zhou, Prakash Nagarkatti, Yin Zhong, Mitzi Nagarkatti.
Anticancer Res, 2011 Dec 27; 31(12). PMID: 22199267    Free PMC article.
Effector CD8+ T cell IFN-γ production and cytotoxicity are enhanced by mild hyperthermia.
Thomas A Mace, Lingwen Zhong, Kathleen M Kokolus, Elizabeth A Repasky.
Int J Hyperthermia, 2012 Jan 13; 28(1). PMID: 22235780    Free PMC article.
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin.
John E Harris, Tajie H Harris, +3 authors, Laurence A Turka.
J Invest Dermatol, 2012 Feb 03; 132(7). PMID: 22297636    Free PMC article.
Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells.
Vivian L Weiss, Timothy H Lee, +5 authors, Todd D Armstrong.
PLoS One, 2012 Feb 24; 7(2). PMID: 22359647    Free PMC article.
Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host.
Mark P Rubinstein, Colleen A Cloud, +7 authors, David J Cole.
J Am Coll Surg, 2012 Mar 01; 214(4). PMID: 22360982    Free PMC article.
A potent vaccination strategy that circumvents lymphodepletion for effective antitumor adoptive T-cell therapy.
Hyun-Il Cho, Eduardo Reyes-Vargas, Julio C Delgado, Esteban Celis.
Cancer Res, 2012 Mar 01; 72(8). PMID: 22367213    Free PMC article.
Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo.
Chengwen Liu, Carol M Lewis, +8 authors, Patrick Hwu.
J Immunother, 2012 Mar 17; 35(3). PMID: 22421945    Free PMC article.
Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma.
Jose Pulido, Timothy Kottke, +11 authors, Richard Vile.
Nat Biotechnol, 2012 Mar 20; 30(4). PMID: 22426030    Free PMC article.
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells.
John J Engelhardt, Bijan Boldajipour, +5 authors, Matthew F Krummel.
Cancer Cell, 2012 Mar 24; 21(3). PMID: 22439936    Free PMC article.
Highly Cited.
Advances in the treatment of metastatic melanoma: adoptive T-cell therapy.
Chantale Bernatchez, Laszlo G Radvanyi, Patrick Hwu.
Semin Oncol, 2012 Apr 10; 39(2). PMID: 22484193    Free PMC article.
Review.
BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy.
Richard C Koya, Stephen Mok, +8 authors, Antoni Ribas.
Cancer Res, 2012 Jun 14; 72(16). PMID: 22693252    Free PMC article.
Highly Cited.
T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy.
Jon G Quatromoni, Yue Wang, +6 authors, James S Economou.
J Transl Med, 2012 Jun 21; 10. PMID: 22713761    Free PMC article.
Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.
Shawn M Jensen, Christopher G Twitty, +6 authors, Bernard A Fox.
J Immunol, 2012 Jun 23; 189(2). PMID: 22723522    Free PMC article.
Adoptive transfer of cytotoxic T lymphocytes targeting two different antigens limits antigen loss and tumor escape.
Karen M Kaluza, Timothy Kottke, +3 authors, Richard Vile.
Hum Gene Ther, 2012 Jun 28; 23(10). PMID: 22734672    Free PMC article.
Optimization of stability, encapsulation, release, and cross-priming of tumor antigen-containing PLGA nanoparticles.
Shashi Prasad, Virginia Cody, +4 authors, Douglas J Hanlon.
Pharm Res, 2012 Jul 17; 29(9). PMID: 22798259    Free PMC article.
A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice.
Shikhar Mehrotra, Amir A Al-Khami, +15 authors, Michael I Nishimura.
J Immunol, 2012 Jul 17; 189(4). PMID: 22798675    Free PMC article.
Multi-compartmental vaccine delivery system for enhanced immune response to gp100 peptide antigen in melanoma immunotherapy.
Mayurkumar Kalariya, Srinivas Ganta, Mansoor Amiji.
Pharm Res, 2012 Jul 19; 29(12). PMID: 22806408
Systemic combination virotherapy for melanoma with tumor antigen-expressing vesicular stomatitis virus and adoptive T-cell transfer.
Diana M Rommelfanger, Phonphimon Wongthida, +4 authors, Richard G Vile.
Cancer Res, 2012 Jul 28; 72(18). PMID: 22836753    Free PMC article.
NFAT1 supports tumor-induced anergy of CD4(+) T cells.
Brian T Abe, Daniel S Shin, Enric Mocholi, Fernando Macian.
Cancer Res, 2012 Aug 07; 72(18). PMID: 22865456    Free PMC article.
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype.
Daniel Hirschhorn-Cymerman, Sadna Budhu, +10 authors, Jedd D Wolchok.
J Exp Med, 2012 Sep 26; 209(11). PMID: 23008334    Free PMC article.
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.
Jennifer Landsberg, Judith Kohlmeyer, +8 authors, Thomas Tüting.
Nature, 2012 Oct 12; 490(7420). PMID: 23051752
Highly Cited.
Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?
Christopher A Klebanoff, Luca Gattinoni, Nicholas P Restifo.
J Immunother, 2012 Oct 24; 35(9). PMID: 23090074    Free PMC article.
Highly Cited. Review.
The past, present, and future of adoptive T cell therapy.
Donghoon Choi, Tai-Gyu Kim, Young Chul Sung.
Immune Netw, 2012 Oct 24; 12(4). PMID: 23091437    Free PMC article.
Genetically engineered T cells for the treatment of cancer.
M Essand, A S I Loskog.
J Intern Med, 2012 Dec 04; 273(2). PMID: 23198862    Free PMC article.
Review.
BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.
Chengwen Liu, Weiyi Peng, +18 authors, Patrick Hwu.
Clin Cancer Res, 2012 Dec 04; 19(2). PMID: 23204132    Free PMC article.
Highly Cited.
Clinical opportunities in combining immunotherapy with radiation therapy.
Steven E Finkelstein, Mayer Fishman.
Front Oncol, 2012 Dec 13; 2. PMID: 23233905    Free PMC article.
Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.
Yu Yu, Hyun-Ii Cho, +4 authors, Xue-Zhong Yu.
J Immunol, 2013 Jan 15; 190(4). PMID: 23315072    Free PMC article.
A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity.
Xiaofei Yu, Chunqing Guo, +4 authors, Xiang-Yang Wang.
Cancer Res, 2013 Jan 22; 73(7). PMID: 23333935    Free PMC article.
Anti-CD20 antibody promotes cancer escape via enrichment of tumor-evoked regulatory B cells expressing low levels of CD20 and CD137L.
Monica Bodogai, Catalina Lee Chang, +7 authors, Arya Biragyn.
Cancer Res, 2013 Feb 01; 73(7). PMID: 23365136    Free PMC article.
High-density sub-100-nm peptide-gold nanoparticle complexes improve vaccine presentation by dendritic cells in vitro.
Adam Yuh Lin, Jessica Lunsford, +5 authors, Rebekah Anna Drezek.
Nanoscale Res Lett, 2013 Feb 14; 8(1). PMID: 23402570    Free PMC article.
Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor α.
Katarzyna Wejksza, Catalina Lee-Chang, +5 authors, Arya Biragyn.
J Immunol, 2013 Feb 15; 190(6). PMID: 23408836    Free PMC article.
Mutant HSP70 reverses autoimmune depigmentation in vitiligo.
Jeffrey A Mosenson, Andrew Zloza, +17 authors, I Caroline Le Poole.
Sci Transl Med, 2013 Mar 01; 5(174). PMID: 23447019    Free PMC article.
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.
Yared Hailemichael, Zhimin Dai, +17 authors, Willem W Overwijk.
Nat Med, 2013 Mar 05; 19(4). PMID: 23455713    Free PMC article.
Highly Cited.
Engineering improved T cell receptors using an alanine-scan guided T cell display selection system.
Karolina Malecek, Shi Zhong, +5 authors, Michelle Krogsgaard.
J Immunol Methods, 2013 Mar 19; 392(1-2). PMID: 23500145    Free PMC article.
The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity.
Shin Foong Ngiow, Bianca von Scheidt, +2 authors, Michele W L Teng.
Oncoimmunology, 2013 Mar 26; 2(2). PMID: 23524369    Free PMC article.
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy.
Shi Zhong, Karolina Malecek, +12 authors, Michelle Krogsgaard.
Proc Natl Acad Sci U S A, 2013 Apr 12; 110(17). PMID: 23576742    Free PMC article.
Highly Cited.
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Boris Engels, Victor H Engelhard, +7 authors, Hans Schreiber.
Cancer Cell, 2013 Apr 20; 23(4). PMID: 23597565    Free PMC article.
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
Jan C Dudda, Bruno Salaun, +16 authors, Pedro Romero.
Immunity, 2013 Apr 23; 38(4). PMID: 23601686    Free PMC article.
Highly Cited.
Local administration of TLR ligands rescues the function of tumor-infiltrating CD8 T cells and enhances the antitumor effect of lentivector immunization.
Haiyan Xiao, Yibing Peng, +7 authors, Yukai He.
J Immunol, 2013 Apr 24; 190(11). PMID: 23610140    Free PMC article.
Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.
Dhanalakshmi Chinnasamy, Eric Tran, +3 authors, Steven A Rosenberg.
Cancer Res, 2013 May 02; 73(11). PMID: 23633494    Free PMC article.
In vivo intracellular oxygen dynamics in murine brain glioma and immunotherapeutic response of cytotoxic T cells observed by fluorine-19 magnetic resonance imaging.
Jia Zhong, Masashi Sakaki, Hideho Okada, Eric T Ahrens.
PLoS One, 2013 May 15; 8(5). PMID: 23667419    Free PMC article.
Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse.
Nicolas Boisgerault, Timothy Kottke, +11 authors, Richard Vile.
Mol Ther, 2013 Jun 12; 21(8). PMID: 23752316    Free PMC article.
In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes.
Yiran Zheng, Matthias T Stephan, +3 authors, Darrell J Irvine.
J Control Release, 2013 Jun 19; 172(2). PMID: 23770010    Free PMC article.
Skin-resident antigen-presenting cells: instruction manual for vaccine development.
Cynthia M Fehres, Juan J Garcia-Vallejo, Wendy W J Unger, Yvette van Kooyk.
Front Immunol, 2013 Jun 27; 4. PMID: 23801994    Free PMC article.
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
Gang Li, Qianting Yang, +4 authors, Binfeng Lu.
PLoS One, 2013 Jul 05; 8(6). PMID: 23826287    Free PMC article.
A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model.
Shicheng Yang, Gary E Archer, +2 authors, John H Sampson.
Cancer Immunol Immunother, 2013 Aug 29; 62(11). PMID: 23982483    Free PMC article.
Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells.
Christopher A Klebanoff, Sean P Spencer, +20 authors, Nicholas P Restifo.
J Exp Med, 2013 Sep 04; 210(10). PMID: 23999499    Free PMC article.
Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells.
Catalina Lee-Chang, Monica Bodogai, +5 authors, Arya Biragyn.
J Immunol, 2013 Sep 18; 191(8). PMID: 24043896    Free PMC article.
Adoptive T-cell transfer therapy and oncogene-targeted therapy for melanoma: the search for synergy.
Mei Li M Kwong, Bart Neyns, James C Yang.
Clin Cancer Res, 2013 Oct 04; 19(19). PMID: 24089442    Free PMC article.
Review.
Reassessing target antigens for adoptive T-cell therapy.
Christian S Hinrichs, Nicholas P Restifo.
Nat Biotechnol, 2013 Oct 22; 31(11). PMID: 24142051    Free PMC article.
Highly Cited. Review.
Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance.
Sanmay Bandyopadhyay, Rut Valdor, Fernando Macian.
Mol Cell Biol, 2013 Nov 06; 34(2). PMID: 24190972    Free PMC article.
Tolerance and exhaustion: defining mechanisms of T cell dysfunction.
Andrea Schietinger, Philip D Greenberg.
Trends Immunol, 2013 Nov 12; 35(2). PMID: 24210163    Free PMC article.
Highly Cited. Review.
Understanding the biology of ex vivo-expanded CD8 T cells for adoptive cell therapy: role of CD62L.
C Marcela Díaz-Montero, Abdel-Aziz Zidan, +6 authors, Mathias G Lichtenheld.
Immunol Res, 2013 Nov 13; 57(1-3). PMID: 24218360
Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination.
Hongxia Wang, Xiaofei Yu, +4 authors, Xiang-Yang Wang.
J Immunol, 2013 Nov 13; 191(12). PMID: 24218449    Free PMC article.
Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence.
Timothy Kottke, Nicolas Boisgerault, +12 authors, Richard Vile.
Nat Med, 2013 Nov 19; 19(12). PMID: 24240185    Free PMC article.
Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity.
Alexey Berezhnoy, Iris Castro, +2 authors, Eli Gilboa.
J Clin Invest, 2013 Dec 03; 124(1). PMID: 24292708    Free PMC article.
Cancer immunotherapy: are we there yet?
Zihai Li, Lieping Chen, Mark P Rubinstein.
Exp Hematol Oncol, 2013 Dec 12; 2(1). PMID: 24326015    Free PMC article.
Exploiting the curative potential of adoptive T-cell therapy for cancer.
Christian S Hinrichs, Steven A Rosenberg.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329789    Free PMC article.
Highly Cited. Review.
Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy.
Joseph G Crompton, Madhusudhanan Sukumar, Nicholas P Restifo.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329803    Free PMC article.
Review.
The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity.
Mahdia Benkhoucha, Nicolas Molnarfi, +2 authors, Patrice H Lalive.
J Neuroinflammation, 2013 Dec 19; 10. PMID: 24344806    Free PMC article.
Enhanced responses to tumor immunization following total body irradiation are time-dependent.
Adi Diab, Robert R Jenq, +14 authors, Miguel-Angel Perales.
PLoS One, 2013 Dec 19; 8(12). PMID: 24349298    Free PMC article.
Autoimmune vitiligo does not require the ongoing priming of naive CD8 T cells for disease progression or associated protection against melanoma.
Katelyn T Byrne, Peisheng Zhang, Shannon M Steinberg, Mary Jo Turk.
J Immunol, 2014 Jan 10; 192(4). PMID: 24403535    Free PMC article.
Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032.
Molly H Jenkins, Shannon M Steinberg, +5 authors, Constance E Brinckerhoff.
Pigment Cell Melanoma Res, 2014 Jan 28; 27(3). PMID: 24460976    Free PMC article.
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers.
Yong Lu, Bangxing Hong, +5 authors, Qing Yi.
Proc Natl Acad Sci U S A, 2014 Jan 29; 111(6). PMID: 24469818    Free PMC article.
In vivo discovery of immunotherapy targets in the tumour microenvironment.
Penghui Zhou, Donald R Shaffer, +17 authors, Kai W Wucherpfennig.
Nature, 2014 Jan 31; 506(7486). PMID: 24476824    Free PMC article.
Highly Cited.
Immunotherapy for solid tumors--a review for surgeons.
Abdul Saied, Venu G Pillarisetty, Steven C Katz.
J Surg Res, 2014 Feb 04; 187(2). PMID: 24485876    Free PMC article.
Review.
Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells.
Aaron P Rapoport, Nicole A Aqui, +22 authors, Carl H June.
Clin Cancer Res, 2014 Feb 13; 20(5). PMID: 24520093    Free PMC article.
A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.
Yusuke Shono, Andrea Z Tuckett, +16 authors, Johannes L Zakrzewski.
Cancer Discov, 2014 Feb 20; 4(5). PMID: 24550032    Free PMC article.
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy.
Dmitriy Zamarin, Rikke B Holmgaard, +6 authors, James P Allison.
Sci Transl Med, 2014 Mar 07; 6(226). PMID: 24598590    Free PMC article.
Highly Cited.
Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma.
Thinle Chodon, Begoña Comin-Anduix, +31 authors, Antoni Ribas.
Clin Cancer Res, 2014 Mar 19; 20(9). PMID: 24634374    Free PMC article.
Highly Cited.
Combined treatment of murine fibrosarcoma with chemotherapy (Paclitaxel), radiotherapy, and intratumoral injection of dendritic cells.
Ji-Won Byun, Hyeon-Sook Lee, +5 authors, Gwang-Seong Choi.
Ann Dermatol, 2014 Mar 22; 26(1). PMID: 24648686    Free PMC article.
Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy.
Andrea Z Tuckett, Raymond H Thornton, +5 authors, Johannes L Zakrzewski.
Blood, 2014 Mar 22; 123(18). PMID: 24652996    Free PMC article.
Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumors.
Ruey-Shyang Soong, Liwen Song, +5 authors, Chien-Fu Hung.
PLoS One, 2014 Mar 26; 9(3). PMID: 24664420    Free PMC article.
CD28z CARs and armored CARs.
Hollie J Pegram, Jae H Park, Renier J Brentjens.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667958    Free PMC article.
Review.
Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery.
Ronnie H Fang, Che-Ming J Hu, +5 authors, Liangfang Zhang.
Nano Lett, 2014 Mar 29; 14(4). PMID: 24673373    Free PMC article.
Highly Cited.
Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production.
Shaun O'Brien, Rajan M Thomas, +3 authors, Andrew D Wells.
J Immunol, 2014 Apr 30; 192(11). PMID: 24778448    Free PMC article.
The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes.
Maria H Ulvmar, Kathrin Werth, +12 authors, Antal Rot.
Nat Immunol, 2014 May 13; 15(7). PMID: 24813163
Highly Cited.
Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance.
Stephanie R Jackson, Jinyun Yuan, +4 authors, Ryan M Teague.
J Leukoc Biol, 2014 May 16; 96(3). PMID: 24823810    Free PMC article.
Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing.
Yun Ji, Natalie Abrams, +9 authors, Nicholas P Restifo.
PLoS One, 2014 May 16; 9(5). PMID: 24827921    Free PMC article.
Host STAT2/type I interferon axis controls tumor growth.
Chanyu Yue, Jun Xu, +6 authors, Ana M Gamero.
Int J Cancer, 2014 Jun 05; 136(1). PMID: 24895110    Free PMC article.
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
Regina Lin, Hyoungsu Kim, Jiyong Hong, Qi-Jing Li.
ACS Med Chem Lett, 2014 Jun 06; 5(5). PMID: 24900866    Free PMC article.
Genetically modified T-cell therapy for osteosarcoma.
Christopher DeRenzo, Stephen Gottschalk.
Adv Exp Med Biol, 2014 Jun 14; 804. PMID: 24924183    Free PMC article.
Review.
Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation.
Jonathan M Eby, Hee-Kap Kang, +8 authors, I Caroline Le Poole.
Pigment Cell Melanoma Res, 2014 Jun 18; 27(6). PMID: 24935676    Free PMC article.
DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth.
Jin-Sung Chung, Kyoichi Tamura, Ponciano D Cruz, Kiyoshi Ariizumi.
J Invest Dermatol, 2014 Jun 18; 134(11). PMID: 24936834    Free PMC article.
Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity.
Catalina Lee-Chang, Monica Bodogai, +9 authors, Arya Biragyn.
Blood, 2014 Jul 20; 124(9). PMID: 25037628    Free PMC article.
The profile of tumor antigens which can be targeted by immunotherapy depends upon the tumor's anatomical site.
Vanesa Alonso-Camino, Karishma Rajani, +12 authors, Richard Vile.
Mol Ther, 2014 Jul 26; 22(11). PMID: 25059678    Free PMC article.
BRAF inhibition alleviates immune suppression in murine autochthonous melanoma.
Shannon M Steinberg, Peisheng Zhang, +8 authors, Mary Jo Turk.
Cancer Immunol Res, 2014 Sep 04; 2(11). PMID: 25183499    Free PMC article.
Cancer immunotherapy in clinical practice -- the past, present, and future.
Gaurav Goel, Weijing Sun.
Chin J Cancer, 2014 Sep 06; 33(9). PMID: 25189717    Free PMC article.
Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression.
Regina Lin, Ling Chen, +7 authors, Qi-Jing Li.
J Clin Invest, 2014 Oct 28; 124(12). PMID: 25347474    Free PMC article.
Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest.
Nicolas Acquavella, David Clever, +24 authors, Nicholas P Restifo.
Cancer Immunol Res, 2014 Nov 02; 3(1). PMID: 25358764    Free PMC article.
Review: cancer-induced autoimmunity in the rheumatic diseases.
Ami A Shah, Livia Casciola-Rosen, Antony Rosen.
Arthritis Rheumatol, 2014 Nov 06; 67(2). PMID: 25371098    Free PMC article.
Review.
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.
Joseph G Crompton, Madhusudhanan Sukumar, +21 authors, Nicholas P Restifo.
Cancer Res, 2014 Nov 30; 75(2). PMID: 25432172    Free PMC article.
Highly Cited.
Simvastatin prevents and reverses depigmentation in a mouse model of vitiligo.
Priti Agarwal, Mehdi Rashighi, +5 authors, John E Harris.
J Invest Dermatol, 2014 Dec 19; 135(4). PMID: 25521459    Free PMC article.
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.
Yun Ji, Claudia Wrzesinski, +14 authors, Luca Gattinoni.
Proc Natl Acad Sci U S A, 2014 Dec 31; 112(2). PMID: 25548153    Free PMC article.
Overcoming tumor immune evasion with an unique arbovirus.
Bruce Lyday, Tony Chen, Santosh Kesari, Boris Minev.
J Transl Med, 2015 Jan 17; 13. PMID: 25592450    Free PMC article.
Review.
CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo.
Jonathan M Eby, Hee-Kap Kang, +5 authors, I Caroline Le Poole.
J Invest Dermatol, 2015 Jan 31; 135(6). PMID: 25634358    Free PMC article.
Mouse model for pre-clinical study of human cancer immunotherapy.
Zhiya Ya, Yared Hailemichael, Willem Overwijk, Nicholas P Restifo.
Curr Protoc Immunol, 2015 Feb 03; 108. PMID: 25640991    Free PMC article.
Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells.
Mark P Rubinstein, Ee Wern Su, +13 authors, David J Cole.
Cancer Immunol Immunother, 2015 Feb 14; 64(5). PMID: 25676709    Free PMC article.
Histotripsy methods in mechanical disintegration of tissue: towards clinical applications.
Vera A Khokhlova, J Brian Fowlkes, +7 authors, Charles A Cain.
Int J Hyperthermia, 2015 Feb 25; 31(2). PMID: 25707817    Free PMC article.
Highly Cited. Review.
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma.
Siwen Hu-Lieskovan, Stephen Mok, +8 authors, Antoni Ribas.
Sci Transl Med, 2015 Mar 20; 7(279). PMID: 25787767    Free PMC article.
Highly Cited.
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.
Jacob S Bowers, Michelle H Nelson, +6 authors, Chrystal M Paulos.
Clin Cancer Res, 2015 Apr 24; 21(11). PMID: 25904754    Free PMC article.
STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice.
Zili Wang, Esteban Celis.
Cancer Immunol Immunother, 2015 May 20; 64(8). PMID: 25986168    Free PMC article.
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
A B Rodriguez-Peña, J Gomez-Rodriguez, +14 authors, L Balagopalan.
Gene Ther, 2015 May 29; 22(10). PMID: 26018935    Free PMC article.
Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma.
Saleh Rachidi, Kristin Wallace, +3 authors, Zihai Li.
Head Neck, 2015 Jun 05; 38 Suppl 1. PMID: 26040762    Free PMC article.
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.
Rosa Barreira da Silva, Melissa E Laird, +3 authors, Matthew L Albert.
Nat Immunol, 2015 Jun 16; 16(8). PMID: 26075911
Highly Cited.
Challenges and future perspectives of T cell immunotherapy in cancer.
Maria Teresa P de Aquino, Anshu Malhotra, Manoj K Mishra, Anil Shanker.
Immunol Lett, 2015 Jun 23; 166(2). PMID: 26096822    Free PMC article.
Review.
Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model.
David G Mairhofer, Daniela Ortner, +10 authors, Patrizia Stoitzner.
J Invest Dermatol, 2015 Jun 30; 135(11). PMID: 26121214    Free PMC article.
Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells.
Monica Bodogai, Kanako Moritoh, +8 authors, Arya Biragyn.
Cancer Res, 2015 Jul 18; 75(17). PMID: 26183924    Free PMC article.
Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Rα Dependent.
C Bryce Johnson, Brian P Riesenberg, +7 authors, Mark P Rubinstein.
Cancer Immunol Res, 2015 Aug 25; 3(12). PMID: 26297711    Free PMC article.
IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses.
Xuefeng Wang, Xin Zhao, +19 authors, Binfeng Lu.
Cancer Cell, 2015 Sep 01; 28(3). PMID: 26321222    Free PMC article.
The nitric oxide radical scavenger carboxy-PTIO reduces the immunosuppressive activity of myeloid-derived suppressor cells and potentiates the antitumor activity of adoptive cytotoxic T lymphocyte immunotherapy.
Kosuke Hirano, Akihiro Hosoi, +5 authors, Kazuhiro Kakimi.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405569    Free PMC article.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Kyle A Wilson, Stephen R Goding, +2 authors, Paul Andrew Antony.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570    Free PMC article.
Definitive Management of Oligometastatic Melanoma in a Murine Model Using Combined Ablative Radiation Therapy and Viral Immunotherapy.
Miran Blanchard, Kevin G Shim, +12 authors, Richard Vile.
Int J Radiat Oncol Biol Phys, 2015 Oct 16; 93(3). PMID: 26461000    Free PMC article.
Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.
Carmen S M Yong, Jennifer A Westwood, +6 authors, Michael H Kershaw.
PLoS One, 2015 Oct 28; 10(10). PMID: 26505904    Free PMC article.
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.
Douglas C Palmer, Geoffrey C Guittard, +17 authors, Nicholas P Restifo.
J Exp Med, 2015 Nov 04; 212(12). PMID: 26527801    Free PMC article.
A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality.
Wei Zhu, Claire Germain, +12 authors, Brandon W Higgs.
Oncoimmunology, 2015 Nov 21; 4(12). PMID: 26587322    Free PMC article.
Engineering opportunities in cancer immunotherapy.
Laura Jeanbart, Melody A Swartz.
Proc Natl Acad Sci U S A, 2015 Nov 26; 112(47). PMID: 26598681    Free PMC article.
Review.
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.
Madhav D Sharma, Rahul Shinde, +12 authors, David H Munn.
Sci Adv, 2015 Nov 26; 1(10). PMID: 26601142    Free PMC article.
Highly Cited.
Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.
Michele M Hoffmann, Carlos Molina-Mendiola, +7 authors, Diana Gil.
Sci Adv, 2015 Nov 26; 1(9). PMID: 26601285    Free PMC article.
Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens.
Michael Hebeisen, Mathilde Allard, +3 authors, Nathalie Rufer.
Front Immunol, 2015 Dec 05; 6. PMID: 26635796    Free PMC article.
Review.
Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.
Christopher A Klebanoff, Christopher D Scott, +24 authors, Nicholas P Restifo.
J Clin Invest, 2015 Dec 15; 126(1). PMID: 26657860    Free PMC article.
Highly Cited.
Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells.
Cong Ye, Zhe Geng, +7 authors, Bin Zhang.
J Immunol, 2015 Dec 15; 196(2). PMID: 26663722    Free PMC article.
Identification of an Immunogenic Subset of Metastatic Uveal Melanoma.
Luke D Rothermel, Arvind C Sabesan, +12 authors, Udai S Kammula.
Clin Cancer Res, 2015 Dec 30; 22(9). PMID: 26712692    Free PMC article.
Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice.
Stefanie N Linch, Melissa J Kasiewicz, +3 authors, William L Redmond.
Proc Natl Acad Sci U S A, 2016 Jan 06; 113(3). PMID: 26729864    Free PMC article.
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape.
Sanmay Bandyopadhyay, Thomas J Quinn, +5 authors, Chandan Guha.
J Immunol, 2016 Jan 13; 196(4). PMID: 26755821    Free PMC article.
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
Elien M Doorduijn, Marjolein Sluijter, +5 authors, Thorbald van Hall.
J Clin Invest, 2016 Jan 20; 126(2). PMID: 26784543    Free PMC article.
MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.
Vani Lakshminarayanan, Nitin T Supekar, +12 authors, Sandra J Gendler.
PLoS One, 2016 Jan 21; 11(1). PMID: 26788922    Free PMC article.
Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant.
Brian M Andersen, Junzhe Xia, +5 authors, Michael R Olin.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885373    Free PMC article.
Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses.
Nicholas M Molino, Medea Neek, +2 authors, Szu-Wen Wang.
Biomaterials, 2016 Feb 20; 86. PMID: 26894870    Free PMC article.
Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers.
Catalina Lee-Chang, Monica Bodogai, +7 authors, Arya Biragyn.
J Immunol, 2016 Mar 18; 196(8). PMID: 26983789    Free PMC article.
Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
Jonathan T Sockolosky, Michael Dougan, +5 authors, K Christopher Garcia.
Proc Natl Acad Sci U S A, 2016 Apr 20; 113(19). PMID: 27091975    Free PMC article.
Highly Cited.
Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity.
Thomas V Guy, Alexandra M Terry, +6 authors, Barbara Fazekas de St. Groth.
Oncotarget, 2016 Apr 29; 7(21). PMID: 27121060    Free PMC article.
Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory.
Hidehito Saito, Keisuke Okita, Alfred E Chang, Fumito Ito.
Cancer Res, 2016 May 20; 76(12). PMID: 27197199    Free PMC article.
Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors.
Rikke B Holmgaard, Dmitriy Zamarin, +2 authors, Jedd D Wolchok.
EBioMedicine, 2016 May 24; 6. PMID: 27211548    Free PMC article.
Highly Cited.
The modulation of Dicer regulates tumor immunogenicity in melanoma.
Nicholas C Hoffend, William J Magner, Thomas B Tomasi.
Oncotarget, 2016 Jul 01; 7(30). PMID: 27356752    Free PMC article.
Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden.
Anna Sanecka, Nagisa Yoshida, +5 authors, Eva-Maria Frickel.
Immunology, 2016 Jul 06; 149(3). PMID: 27377596    Free PMC article.
Targeted Programming of the Lymph Node Environment Causes Evolution of Local and Systemic Immunity.
James I Andorko, Joshua M Gammon, +2 authors, Christopher M Jewell.
Cell Mol Bioeng, 2016 Aug 23; 9. PMID: 27547269    Free PMC article.
Optimized tumor cryptic peptides: the basis for universal neo-antigen-like tumor vaccines.
Jeanne Menez-Jamet, Catherine Gallou, Aude Rougeot, Kostas Kosmatopoulos.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563653    Free PMC article.
Review.
BPTF Depletion Enhances T-cell-Mediated Antitumor Immunity.
Kimberly Mayes, Suehyb G Alkhatib, +8 authors, Joseph W Landry.
Cancer Res, 2016 Nov 03; 76(21). PMID: 27651309    Free PMC article.
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination.
Anke Redeker, Ramon Arens.
Front Immunol, 2016 Sep 23; 7. PMID: 27656185    Free PMC article.
Review.
Adjuvants for peptide-based cancer vaccines.
Hiep Khong, Willem W Overwijk.
J Immunother Cancer, 2016 Sep 24; 4. PMID: 27660710    Free PMC article.
Review.
Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death.
Matthew J Scheffel, Gina Scurti, +4 authors, Christina Voelkel-Johnson.
Cancer Res, 2016 Oct 16; 76(20). PMID: 27742673    Free PMC article.
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.
Kelly D Moynihan, Cary F Opel, +19 authors, Darrell J Irvine.
Nat Med, 2016 Nov 01; 22(12). PMID: 27775706    Free PMC article.
Highly Cited.
PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.
Christian J Maine, John R Teijaro, Kristi Marquardt, Linda A Sherman.
Proc Natl Acad Sci U S A, 2016 Nov 02; 113(46). PMID: 27799548    Free PMC article.
Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers.
Qiong J Wang, Zhiya Yu, +4 authors, James C Yang.
Clin Cancer Res, 2016 Nov 03; 23(9). PMID: 27803044    Free PMC article.
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.
Olivier De Henau, Matthew Rausch, +21 authors, Taha Merghoub.
Nature, 2016 Nov 10; 539(7629). PMID: 27828943    Free PMC article.
Highly Cited.
Homologous Prime-Boost Vaccination with OVA Entrapped in Self-Adjuvanting Archaeosomes Induces High Numbers of OVA-Specific CD8⁺ T Cells that Protect Against Subcutaneous B16-OVA Melanoma.
Felicity C Stark, Michael J McCluskie, Lakshmi Krishnan.
Vaccines (Basel), 2016 Nov 22; 4(4). PMID: 27869670    Free PMC article.
Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment.
E Eriksson, R Moreno, +9 authors, A Loskog.
Gene Ther, 2016 Dec 03; 24(2). PMID: 27906162    Free PMC article.
Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.
Latha B Pathangey, Dustin B McCurry, +7 authors, Peter A Cohen.
Oncotarget, 2016 Dec 16; 8(7). PMID: 27974697    Free PMC article.
Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion.
Sinnie Sin Man Ng, Bethany A Nagy, +6 authors, George N Pavlakis.
Clin Cancer Res, 2016 Dec 18; 23(11). PMID: 27986749    Free PMC article.
Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors.
Gang Xin, David M Schauder, +4 authors, Weiguo Cui.
Proc Natl Acad Sci U S A, 2017 Jan 11; 114(4). PMID: 28069963    Free PMC article.
Inferring the Impact of Regulatory Mechanisms that Underpin CD8+ T Cell Control of B16 Tumor Growth In vivo Using Mechanistic Models and Simulation.
David J Klinke, Qing Wang.
Front Pharmacol, 2017 Jan 20; 7. PMID: 28101055    Free PMC article.
The development of dendritic cell vaccine-based immunotherapies for glioblastoma.
David A Reardon, Duane A Mitchell.
Semin Immunopathol, 2017 Feb 01; 39(2). PMID: 28138787
Review.
Inhibitory Receptors Induced by VSV Viroimmunotherapy Are Not Necessarily Targets for Improving Treatment Efficacy.
Kevin G Shim, Shane Zaidi, +8 authors, Richard G Vile.
Mol Ther, 2017 Feb 27; 25(4). PMID: 28237836    Free PMC article.
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.
Daniel J Neitzke, Jacob S Bowers, +7 authors, Mark P Rubinstein.
Cancer Immunol Immunother, 2017 Mar 11; 66(6). PMID: 28280853    Free PMC article.
The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response.
Kun He, Ping Liu, Lisa X Xu.
Cell Death Dis, 2017 Mar 24; 8(3). PMID: 28333145    Free PMC article.
Tuning cancer fate: the unremitting role of host immunity.
B Calì, B Molon, A Viola.
Open Biol, 2017 Apr 14; 7(4). PMID: 28404796    Free PMC article.
Review.
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Kyun-Do Kim, Seyeon Bae, +8 authors, Minsoo Kim.
Nat Commun, 2017 May 16; 8. PMID: 28504276    Free PMC article.
SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.
Jungsun Park, Amjad H Talukder, +17 authors, Cassian Yee.
Cancer Immunol Res, 2017 Jun 21; 5(8). PMID: 28630054    Free PMC article.
Activation of IRF3 contributes to IFN-γ and ISG54 expression during the immune responses to B16F10 tumor growth.
Zachary Guinn, Deborah M Brown, Thomas M Petro.
Int Immunopharmacol, 2017 Jun 27; 50. PMID: 28651122    Free PMC article.
Resident memory T cells in the skin mediate durable immunity to melanoma.
Brian T Malik, Katelyn T Byrne, +9 authors, Mary Jo Turk.
Sci Immunol, 2017 Jul 25; 2(10). PMID: 28738020    Free PMC article.
Highly Cited.
Identification of a novel population of highly cytotoxic c-Met-expressing CD8+ T lymphocytes.
Mahdia Benkhoucha, Nicolas Molnarfi, +7 authors, Patrice H Lalive.
EMBO Rep, 2017 Jul 29; 18(9). PMID: 28751311    Free PMC article.
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis.
Saleh Rachidi, Alessandra Metelli, +11 authors, Zihai Li.
Sci Immunol, 2017 Aug 02; 2(11). PMID: 28763790    Free PMC article.
Highly Cited.
Identification of essential genes for cancer immunotherapy.
Shashank J Patel, Neville E Sanjana, +21 authors, Nicholas P Restifo.
Nature, 2017 Aug 08; 548(7669). PMID: 28783722    Free PMC article.
Highly Cited.
Combining dendritic cells and B cells for presentation of oxidised tumour antigens to CD8+ T cells.
Melanie L Grant, Nicholas Shields, +5 authors, Sarah L Young.
Clin Transl Immunology, 2017 Aug 10; 6(7). PMID: 28791124    Free PMC article.
Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells.
Thomas Shum, Bilal Omer, +13 authors, Cliona M Rooney.
Cancer Discov, 2017 Aug 24; 7(11). PMID: 28830878    Free PMC article.
Highly Cited.
The Antitumor Effects of Vaccine-Activated CD8+ T Cells Associate with Weak TCR Signaling and Induction of Stem-Like Memory T Cells.
Sha Wu, Wei Zhu, +11 authors, Yukai He.
Cancer Immunol Res, 2017 Aug 31; 5(10). PMID: 28851693    Free PMC article.
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment.
Sadna Budhu, David A Schaer, +8 authors, Jedd D Wolchok.
Sci Signal, 2017 Aug 31; 10(494). PMID: 28851824    Free PMC article.
Epstein Barr virus Latent Membrane Protein-1 enhances dendritic cell therapy lymph node migration, activation, and IL-12 secretion.
James M Termini, Sachin Gupta, +5 authors, Geoffrey W Stone.
PLoS One, 2017 Sep 15; 12(9). PMID: 28910387    Free PMC article.
Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence.
Tim Kottke, Laura Evgin, +12 authors, Richard Vile.
Cancer Immunol Res, 2017 Oct 19; 5(11). PMID: 29038298    Free PMC article.
Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity.
Shan He, Yongnian Liu, +13 authors, Yi Zhang.
Nat Commun, 2017 Dec 16; 8(1). PMID: 29242551    Free PMC article.
In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model.
Cara L Haymaker, Yared Hailemichael, Yi Yang, Roza Nurieva.
J Vis Exp, 2017 Dec 30; (129). PMID: 29286361    Free PMC article.
A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing.
Deng Pan, Aya Kobayashi, +13 authors, Kai W Wucherpfennig.
Science, 2018 Jan 06; 359(6377). PMID: 29301958    Free PMC article.
Highly Cited.
Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.
Madhav D Sharma, Paulo C Rodriguez, +16 authors, David H Munn.
Immunity, 2018 Jan 19; 48(1). PMID: 29343444    Free PMC article.
Highly Cited.
Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy.
Akihiro Hosoi, Kazuyoshi Takeda, +10 authors, Kazuhiro Kakimi.
Sci Rep, 2018 Jan 20; 8(1). PMID: 29348598    Free PMC article.
PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin.
Xiao Miao, Rong Xu, +5 authors, Bin Li.
Sci Rep, 2018 Jan 27; 8(1). PMID: 29371688    Free PMC article.
N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner.
Matthew J Scheffel, Gina Scurti, +4 authors, Christina Voelkel-Johnson.
Cancer Immunol Immunother, 2018 Feb 06; 67(4). PMID: 29396710    Free PMC article.
T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy.
Elien M Doorduijn, Marjolein Sluijter, +3 authors, Thorbald van Hall.
Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399388    Free PMC article.
Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models.
Grammatiki Fotaki, Chuan Jin, +5 authors, Magnus Essand.
Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399398    Free PMC article.
Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.
Yared Hailemichael, Amber Woods, +17 authors, Willem W Overwijk.
J Clin Invest, 2018 Feb 27; 128(4). PMID: 29480817    Free PMC article.
Highly Cited.
17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.
Sandeep S Joshi, Shunlin Jiang, +4 authors, Thomas J Hornyak.
PLoS One, 2018 Feb 27; 13(2). PMID: 29481571    Free PMC article.
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
Jonathan T Sockolosky, Eleonora Trotta, +15 authors, K Christopher Garcia.
Science, 2018 Mar 03; 359(6379). PMID: 29496879    Free PMC article.
Highly Cited.
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Sarah L Buchan, Mohannad Fallatah, +8 authors, Aymen Al-Shamkhani.
Clin Cancer Res, 2018 Mar 09; 24(10). PMID: 29514845    Free PMC article.
Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma.
Kendra C Foley, Michael I Nishimura, Tamson V Moore.
Melanoma Res, 2018 Mar 10; 28(3). PMID: 29521881    Free PMC article.
Review.
Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.
Raul Vizcardo, Nicholas D Klemen, +20 authors, Nicholas P Restifo.
Cell Rep, 2018 Mar 22; 22(12). PMID: 29562175    Free PMC article.
Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8+ T Cells.
C Bryce Johnson, Bennett R May, +10 authors, Mark P Rubinstein.
Cancer Res, 2018 Apr 11; 78(11). PMID: 29636345    Free PMC article.
In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo.
Xiao Hu, Kinga Majchrzak, +6 authors, Chrystal M Paulos.
Cancer Res, 2018 May 18; 78(14). PMID: 29769201    Free PMC article.
Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma.
Felipe Gálvez-Cancino, Ernesto López, +11 authors, Alvaro Lladser.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900048    Free PMC article.
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery.
Li Tang, Yiran Zheng, +9 authors, Darrell J Irvine.
Nat Biotechnol, 2018 Jul 10; 36(8). PMID: 29985479    Free PMC article.
Highly Cited.
Skin-resident memory T cells as a potential new therapeutic target in vitiligo and melanoma.
Marcella Willemsen, Rugile Linkutė, Rosalie M Luiten, Tiago R Matos.
Pigment Cell Melanoma Res, 2019 Jun 24; 32(5). PMID: 31230406    Free PMC article.
Review.
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.
Ping-Hsien Lee, Tori N Yamamoto, +11 authors, Nicholas P Restifo.
J Exp Med, 2019 Aug 14; 216(11). PMID: 31405895    Free PMC article.
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
Nicholas Collins, Seong-Ji Han, +12 authors, Yasmine Belkaid.
Cell, 2019 Aug 24; 178(5). PMID: 31442402    Free PMC article.
Highly Cited.
Cx43-Gap Junctions Accumulate at the Cytotoxic Immunological Synapse Enabling Cytotoxic T Lymphocyte Melanoma Cell Killing.
Francisca Hofmann, Mariela Navarrete, +4 authors, Flavio Salazar-Onfray.
Int J Mol Sci, 2019 Sep 25; 20(18). PMID: 31547237    Free PMC article.
Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries.
Govinda Sharma, Craig M Rive, Robert A Holt.
Nat Commun, 2019 Oct 09; 10(1). PMID: 31591401    Free PMC article.
Enterotoxins can support CAR T cells against solid tumors.
Bianca von Scheidt, Minyu Wang, +9 authors, Clare Y Slaney.
Proc Natl Acad Sci U S A, 2019 Nov 27; 116(50). PMID: 31767744    Free PMC article.
CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer.
Ryan Zander, David Schauder, +4 authors, Weiguo Cui.
Immunity, 2019 Dec 08; 51(6). PMID: 31810883    Free PMC article.
Highly Cited.
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.
Jun Wei, Lingyun Long, +14 authors, Hongbo Chi.
Nature, 2019 Dec 13; 576(7787). PMID: 31827283    Free PMC article.
Checkpoint blockade immunotherapy enhances the frequency and effector function of murine tumor-infiltrating T cells but does not alter TCRβ diversity.
Lindsey M Kuehm, Kyle Wolf, +2 authors, Ryan M Teague.
Cancer Immunol Immunother, 2019 May 20; 68(7). PMID: 31104075    Free PMC article.
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Giulia Parisi, Justin D Saco, +18 authors, Antoni Ribas.
Nat Commun, 2020 Feb 02; 11(1). PMID: 32005809    Free PMC article.
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Nat Commun, 2020 Feb 02; 11(1). PMID: 32005826    Free PMC article.
miR-155 Overexpression in OT-1 CD8+ T Cells Improves Anti-Tumor Activity against Low-Affinity Tumor Antigen.
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Mol Ther Oncolytics, 2020 Feb 06; 16. PMID: 32021906    Free PMC article.
The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice.
Hussein Sultan, Takumi Kumai, +3 authors, Esteban Celis.
Cancer Immunol Immunother, 2019 Jan 04; 68(3). PMID: 30604041    Free PMC article.
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J Immunother Cancer, 2020 Jan 22; 8(1). PMID: 31959727    Free PMC article.
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Rebecca L Riding, Jillian M Richmond, John E Harris.
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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.
Nadine van Montfoort, Linda Borst, +13 authors, Thorbald van Hall.
Cell, 2018 Dec 07; 175(7). PMID: 30503208    Free PMC article.
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A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab.
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Clin Cancer Res, 2018 Dec 24; 25(7). PMID: 30573690    Free PMC article.
A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells.
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J Immunol, 2019 Jan 13; 202(4). PMID: 30635393    Free PMC article.
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy.
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Nat Nanotechnol, 2019 Jan 22; 14(3). PMID: 30664751    Free PMC article.
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IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming.
Bernardita Medel, Cristobal Costoya, +7 authors, Fabiola Osorio.
Front Immunol, 2019 Jan 29; 9. PMID: 30687308    Free PMC article.
T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy.
Tori N Yamamoto, Ping-Hsien Lee, +15 authors, Christopher A Klebanoff.
J Clin Invest, 2019 Jan 30; 129(4). PMID: 30694219    Free PMC article.
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TCR Repertoire Analysis Reveals Mobilization of Novel CD8+ T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration.
Hiroyasu Aoki, Satoshi Ueha, +5 authors, Kouji Matsushima.
Front Immunol, 2019 Feb 09; 9. PMID: 30733724    Free PMC article.
NKG2D signaling certifies effector CD8 T cells for memory formation.
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J Immunother Cancer, 2019 Feb 20; 7(1). PMID: 30777125    Free PMC article.
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
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Cell Rep, 2019 Apr 18; 27(3). PMID: 30995478    Free PMC article.
The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming.
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Nat Immunol, 2019 Jun 12; 20(7). PMID: 31182807    Free PMC article.
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Danny N Khalil, Nathan Suek, +18 authors, Taha Merghoub.
J Clin Invest, 2019 Jul 23; 129(8). PMID: 31329159    Free PMC article.
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Biomater Sci, 2019 Jan 31; 7(4). PMID: 30698174    Free PMC article.
Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo.
Jillian M Richmond, James P Strassner, +5 authors, John E Harris.
J Invest Dermatol, 2018 Nov 14; 139(4). PMID: 30423329    Free PMC article.
Identification of Small Molecule Enhancers of Immunotherapy for Melanoma.
Christopher Dextras, Myagmarjav Dashnyam, +13 authors, Anju Singh.
Sci Rep, 2020 Apr 02; 10(1). PMID: 32231230    Free PMC article.
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Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity.
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J Immunother Cancer, 2019 Jul 19; 7(1). PMID: 31315671    Free PMC article.
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq.
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Oncoimmunology, 2020 Apr 22; 9(1). PMID: 32313720    Free PMC article.
IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell.
Lulu Shao, Weizhou Hou, +13 authors, Saumendra N Sarkar.
Cancer Immunol Res, 2019 Jun 27; 7(8). PMID: 31239318    Free PMC article.
Cellular cytotoxicity is a form of immunogenic cell death.
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J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217765    Free PMC article.
Optimization of T-cell Receptor-Modified T Cells for Cancer Therapy.
Dylan J Drakes, Sarwish Rafiq, +4 authors, Renier J Brentjens.
Cancer Immunol Res, 2020 Mar 27; 8(6). PMID: 32209638    Free PMC article.
An effective mouse model for adoptive cancer immunotherapy targeting neoantigens.
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JCI Insight, 2019 May 17; 4(10). PMID: 31092734    Free PMC article.
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Christian U Blank, W Nicholas Haining, +15 authors, Dietmar Zehn.
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Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1.
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Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction.
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Genetically Modified T-Cell Therapy for Osteosarcoma: Into the Roaring 2020s.
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Front Immunol, 2020 Aug 15; 11. PMID: 32793218    Free PMC article.
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Nat Commun, 2020 Aug 13; 11(1). PMID: 32782249    Free PMC article.
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A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells.
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Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels.
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Engineered Cell-Membrane-Coated Nanoparticles Directly Present Tumor Antigens to Promote Anticancer Immunity.
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Adv Mater, 2020 Jun 17; 32(30). PMID: 32538494    Free PMC article.
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Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.
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Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation.
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Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts.
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IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma.
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Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
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TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma.
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Front Immunol, 2021 May 25; 12. PMID: 34025646    Free PMC article.
Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma.
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T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors.
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Engineering T Cells to Express Tumoricidal MDA-7/IL24 Enhances Cancer Immunotherapy.
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Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models.
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