Journal Article
. 2003 Oct;349(19).
doi: 10.1056/NEJMoa032312.

A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer

Paul E Goss 1 James N Ingle  Silvana Martino  Nicholas J Robert  Hyman B Muss  Martine J Piccart  Monica Castiglione  Dongsheng Tu  Lois E Shepherd  Kathleen I Pritchard  Robert B Livingston  Nancy E Davidson  Larry Norton  Edith A Perez  Jeffrey S Abrams  Patrick Therasse  Michael J Palmer  Joseph L Pater  
  • PMID: 14551341
  •     349 citations


Background: In hormone-dependent breast cancer, five years of postoperative tamoxifen therapy--but not tamoxifen therapy of longer duration--prolongs disease-free and overall survival. The aromatase inhibitor letrozole, by suppressing estrogen production, might improve the outcome after the discontinuation of tamoxifen therapy.

Methods: We conducted a double-blind, placebo-controlled trial to test the effectiveness of five years of letrozole therapy in postmenopausal women with breast cancer who have completed five years of tamoxifen therapy. The primary end point was disease-free survival.

Results: A total of 5187 women were enrolled (median follow-up, 2.4 years). At the first interim analysis, there were 207 local or metastatic recurrences of breast cancer or new primary cancers in the contralateral breast--75 in the letrozole group and 132 in the placebo group--with estimated four-year disease-free survival rates of 93 percent and 87 percent, respectively, in the two groups (P< or =0.001 for the comparison of disease-free survival). A total of 42 women in the placebo group and 31 women in the letrozole group died (P=0.25 for the comparison of overall survival). Low-grade hot flashes, arthritis, arthralgia, and myalgia were more frequent in the letrozole group, but vaginal bleeding was less frequent. There were new diagnoses of osteoporosis in 5.8 percent of the women in the letrozole group and 4.5 percent of the women in the placebo group (P=0.07); the rates of fracture were similar. After the first interim analysis, the independent data and safety monitoring committee recommended termination of the trial and prompt communication of the results to the participants.

Conclusions: As compared with placebo, letrozole therapy after the completion of standard tamoxifen treatment significantly improves disease-free survival.

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Update on the use of aromatase inhibitors in early-stage breast cancer.
Georgios Kesisis, Andreas Makris, David Miles.
Breast Cancer Res, 2009 Nov 06; 11(5). PMID: 19889200    Free PMC article.
Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines.
Selma Masri, Sheryl Phung, Xin Wang, Shiuan Chen.
J Steroid Biochem Mol Biol, 2009 Nov 10; 118(4-5). PMID: 19897035    Free PMC article.
The role of SRC-3 in human breast cancer.
Ondrej Gojis, Bharath Rudraraju, +6 authors, Carlo Palmieri.
Nat Rev Clin Oncol, 2009 Dec 23; 7(2). PMID: 20027190
The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells.
Selma Masri, Zheng Liu, +3 authors, Shiuan Chen.
Breast Cancer Res Treat, 2010 Jan 08; 124(1). PMID: 20054641    Free PMC article.
Effects of letrozole on bone biomarkers and femur fracture in female rats.
Z Yonden, M Aydin, +3 authors, B Yilmaz.
J Physiol Biochem, 2010 Feb 02; 65(3). PMID: 20119821
Weight gain is associated with increased risk of hot flashes in breast cancer survivors on aromatase inhibitors.
H Irene Su, Mary D Sammel, +3 authors, Jun J Mao.
Breast Cancer Res Treat, 2010 Feb 26; 124(1). PMID: 20182796    Free PMC article.
Docking and 3D-QSAR studies of diverse classes of human aromatase (CYP19) inhibitors.
Partha Pratim Roy, Kunal Roy.
J Mol Model, 2010 Mar 03; 16(10). PMID: 20195667
A teaching model for aromatase inhibitors after tamoxifen.
Theresa Trotter, Marc Webster, +2 authors, Tyrone Donnon.
J Cancer Educ, 2010 Mar 11; 25(4). PMID: 20217291
RANK ligand: effects of inhibition.
Saby George, Andrew Brenner, John Sarantopoulos, Ronald M Bukowski.
Curr Oncol Rep, 2010 Apr 29; 12(2). PMID: 20425591
Factor V Leiden mutation and thromboembolism risk in women receiving adjuvant tamoxifen for breast cancer.
Judy E Garber, Susan Halabi, +16 authors, Cancer and Leukemia Group B.
J Natl Cancer Inst, 2010 Jun 18; 102(13). PMID: 20554945    Free PMC article.
The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum.
P E Lønning.
Ann Oncol, 2010 Jul 10; 22(3). PMID: 20616198    Free PMC article.
Breast cancer chemoprevention: progress and controversy.
D Lawrence Wickerham.
Surg Oncol Clin N Am, 2010 Jul 14; 19(3). PMID: 20620921    Free PMC article.
American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer.
Harold J Burstein, Ann Alexis Prestrud, +16 authors, American Society of Clinical Oncology.
J Clin Oncol, 2010 Jul 14; 28(23). PMID: 20625130    Free PMC article.
Highly Cited. Systematic Review.
Changes in expression of oestrogen regulated and proliferation genes with neoadjuvant treatment highlight heterogeneity of clinical resistance to the aromatase inhibitor, letrozole.
William R Miller, Alexey Larionov.
Breast Cancer Res, 2010 Jul 22; 12(4). PMID: 20646288    Free PMC article.
The aryl hydrocarbon receptor nuclear translocator-interacting protein 2 suppresses the estrogen receptor signaling via an Arnt-dependent mechanism.
Yanjie Li, Yi Li, Tianmin Zhang, William K Chan.
Arch Biochem Biophys, 2010 Aug 03; 502(2). PMID: 20674540    Free PMC article.
Update on estrogens and the skeleton.
Sundeep Khosla.
J Clin Endocrinol Metab, 2010 Aug 06; 95(8). PMID: 20685883    Free PMC article.
Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer.
Dawn L Hershman, Theresa Shao, +6 authors, Alfred I Neugut.
Breast Cancer Res Treat, 2010 Aug 31; 126(2). PMID: 20803066    Free PMC article.
Highly Cited.
Adjuvant Endocrine Therapy in Early Postmenopausal Breast Cancer.
Christoph Mundhenke, Christian Schem, Walter Jonat.
Breast Care (Basel), 2008 Jan 01; 3(5). PMID: 20824026    Free PMC article.
Minimizing early relapse and maximizing treatment outcomes in hormone-sensitive postmenopausal breast cancer: efficacy review of AI trials.
Christos J Markopoulos.
Cancer Metastasis Rev, 2010 Sep 11; 29(4). PMID: 20830503    Free PMC article.
A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer.
Torsten O Nielsen, Joel S Parker, +12 authors, Matthew J Ellis.
Clin Cancer Res, 2010 Sep 15; 16(21). PMID: 20837693    Free PMC article.
Highly Cited.
The Dark Side of the Moon - the Side Effects of Therapy in a Dynamic Era of Breast Cancer Management.
Richard Greil.
Breast Care (Basel), 2009 Jan 01; 4(3). PMID: 20847873    Free PMC article.
Cortical and trabecular bone at the radius and tibia in postmenopausal breast cancer patients: a Peripheral Quantitative Computed Tomography (pQCT) study.
K A Szabo, C E Webber, +3 authors, A Papaioannou.
Bone, 2010 Sep 28; 48(2). PMID: 20870050    Free PMC article.
Optimizing collection of adverse event data in cancer clinical trials supporting supplemental indications.
Lee D Kaiser, Allen S Melemed, +9 authors, Richard L Schilsky.
J Clin Oncol, 2010 Oct 06; 28(34). PMID: 20921453    Free PMC article.
The impact of systemic therapy following ductal carcinoma in situ.
Jennifer Eng-Wong, Joseph P Costantino, Sandra M Swain.
J Natl Cancer Inst Monogr, 2010 Oct 20; 2010(41). PMID: 20956830    Free PMC article.
Effect of letrozole on plasma lipids, triglycerides, and estradiol in postmenopausal women with metastatic breast cancer.
Jamal Zidan, Lika Chetver, Osamah Hussein, Miriam Zucker.
Oncologist, 2010 Oct 29; 15(11). PMID: 20980416    Free PMC article.
Does tumour dormancy offer a therapeutic target?
Paul E Goss, Ann F Chambers.
Nat Rev Cancer, 2010 Nov 05; 10(12). PMID: 21048784
Highly Cited. Review.
Endocrine Treatment - 'Old-Fashioned' Therapy Becoming Redundant in an Era of Molecular Medicine?
Per Eystein Lønning.
Breast Care (Basel), 2008 Jan 01; 3(6). PMID: 21048907    Free PMC article.
High prevalence of low vitamin D and musculoskeletal complaints in women with breast cancer.
Nicola Napoli, Swapna Vattikuti, +7 authors, Reina Armamento-Villareal.
Breast J, 2010 Nov 13; 16(6). PMID: 21070438    Free PMC article.
Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients.
J M Neuner, T W Yen, +2 authors, A B Nattinger.
Osteoporos Int, 2010 Dec 21; 22(11). PMID: 21170643    Free PMC article.
Synchronous and metachronous bilateral breast cancer: a long-term single-institution experience.
Robert Díaz, Blanca Munárriz, +2 authors, Joaquín Montalar.
Med Oncol, 2011 Jan 05; 29(1). PMID: 21193967
An "omics" approach to determine the mechanisms of acquired aromatase inhibitor resistance.
Shiuan Chen.
OMICS, 2011 Feb 22; 15(6). PMID: 21332390    Free PMC article.
Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer.
K Ted Thurn, Scott Thomas, Amy Moore, Pamela N Munster.
Future Oncol, 2011 Feb 25; 7(2). PMID: 21345145    Free PMC article.
Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer.
Cesar G Sanchez, Cynthia X Ma, +5 authors, Matthew J Ellis.
Breast Cancer Res, 2011 Mar 03; 13(2). PMID: 21362200    Free PMC article.
Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitors.
Angela Brodie, Gauri Sabnis.
Clin Cancer Res, 2011 Mar 19; 17(13). PMID: 21415222    Free PMC article.
Binding features of steroidal and nonsteroidal inhibitors.
Yanyan Hong, Rumana Rashid, Shiuan Chen.
Steroids, 2011 Mar 23; 76(8). PMID: 21420422    Free PMC article.
Breast cancer, sickness absence, income and marital status. A study on life situation 1 year prior diagnosis compared to 3 and 5 years after diagnosis.
Sonja Eaker, Annette Wigertz, +4 authors, Uppsala/Örebro Breast Cancer Group.
PLoS One, 2011 Apr 12; 6(3). PMID: 21479209    Free PMC article.
Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection.
Carmen Criscitiello, Debora Fumagalli, Kamal S Saini, Sherene Loi.
Onco Targets Ther, 2011 May 10; 4. PMID: 21552410    Free PMC article.
Biologic markers determine both the risk and the timing of recurrence in breast cancer.
Laura J Esserman, Dan H Moore, +11 authors, Christopher C Benz.
Breast Cancer Res Treat, 2011 May 21; 129(2). PMID: 21597921    Free PMC article.
Fighting breast cancer: a call for a new paradigm.
Mark Binstock.
Perm J, 2005 Jan 01; 9(1). PMID: 21687489    Free PMC article.
Patient adherence to aromatase inhibitor treatment in the adjuvant setting.
S Verma, Y Madarnas, +2 authors, J Bajcar.
Curr Oncol, 2011 Jun 24; 18 Suppl 1. PMID: 21698059    Free PMC article.
Breast cancer (non-metastatic).
Justin Stebbing, Geoff Delaney, Alastair Thompson.
BMJ Clin Evid, 2011 Jul 02; 2011. PMID: 21718560    Free PMC article.
Systematic Review.
Bone targeted therapies in early breast cancer.
Keo Tabane, Daniel A Vorobiof.
Curr Treat Options Oncol, 2011 Sep 03; 12(4). PMID: 21887503
Pharmacoeconomic considerations in the treatment of breast cancer.
Athanasios Pallis, Vasiliki Tsiantou, Efi Simou, Nikos Maniadakis.
Clinicoecon Outcomes Res, 2010 Jan 01; 2. PMID: 21935314    Free PMC article.
Caring for survivors of breast cancer: perspective of the primary care physician.
S L Smith, E S Wai, C Alexander, S Singh-Carlson.
Curr Oncol, 2011 Oct 08; 18(5). PMID: 21980253    Free PMC article.
Progress in endocrine approaches to the treatment and prevention of breast cancer.
Ifeyinwa Obiorah, V Craig Jordan.
Maturitas, 2011 Oct 11; 70(4). PMID: 21982237    Free PMC article.
Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up.
Meredith M Regan, Patrick Neven, +14 authors, International Breast Cancer Study Group (IBCSG).
Lancet Oncol, 2011 Oct 25; 12(12). PMID: 22018631    Free PMC article.
Highly Cited.
Longer-term outcomes of letrozole versus placebo after 5 years of tamoxifen in the NCIC CTG MA.17 trial: analyses adjusting for treatment crossover.
Huan Jin, Dongsheng Tu, +2 authors, Paul E Goss.
J Clin Oncol, 2011 Nov 02; 30(7). PMID: 22042967    Free PMC article.
An effect of letrozole on gastric cancer?
Ahmed El Hadi, Hazem Al-Momani, Paul Edwards.
J Gastric Cancer, 2011 Nov 15; 11(3). PMID: 22076224    Free PMC article.
The CIRAS study: a case control study to define the clinical, immunologic, and radiographic features of aromatase inhibitor-induced musculoskeletal symptoms.
Victoria K Shanmugam, James McCloskey, +2 authors, Jennifer Eng-Wong.
Breast Cancer Res Treat, 2011 Nov 15; 131(2). PMID: 22076476    Free PMC article.
Putting the cardiovascular safety of aromatase inhibitors in patients with early breast cancer into perspective: a systematic review of the literature.
Muhammad Younus, Michelle Kissner, Lester Reich, Nicola Wallis.
Drug Saf, 2011 Nov 15; 34(12). PMID: 22077502
Systematic Review.
Exemestane in the adjuvant treatment of breast cancer in postmenopausal women.
Muaiad Kittaneh, Stefan Glück.
Breast Cancer (Auckl), 2011 Nov 16; 5. PMID: 22084574    Free PMC article.
Aromatase, breast cancer and obesity: a complex interaction.
Serdar E Bulun, Dong Chen, +2 authors, Hong Zhao.
Trends Endocrinol Metab, 2011 Dec 16; 23(2). PMID: 22169755    Free PMC article.
Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole.
Lauren Nicole Bell, Anne Thi Phuong Nguyen, +8 authors, Consortium on Breast Cancer Pharmacogenomics (COBRA).
J Clin Pharmacol, 2011 Dec 17; 52(12). PMID: 22174434    Free PMC article.
Censored quantile regression for residual lifetimes.
Mi-Ok Kim, Mai Zhou, Jong-Hyeon Jeong.
Lifetime Data Anal, 2011 Dec 21; 18(2). PMID: 22183141
Equipoise: asking the right questions for clinical trial design.
Steven Joffe, Franklin G Miller.
Nat Rev Clin Oncol, 2012 Jan 11; 9(4). PMID: 22231753
Adherence to adjuvant hormonal therapy and its relationship to breast cancer recurrence and survival among low-income women.
Kathryn E Weaver, Fabian Camacho, +2 authors, Gretchen Kimmick.
Am J Clin Oncol, 2012 Feb 09; 36(2). PMID: 22314001    Free PMC article.
Early breast cancer in the older woman.
Ari VanderWalde, Arti Hurria.
Clin Geriatr Med, 2012 Feb 14; 28(1). PMID: 22326036    Free PMC article.
Med1 plays a critical role in the development of tamoxifen resistance.
Arumugam Nagalingam, Mourad Tighiouart, +4 authors, Dipali Sharma.
Carcinogenesis, 2012 Feb 22; 33(4). PMID: 22345290    Free PMC article.
Prevention, diagnosis and treatment of osteoporosis following menopause induced due to oncological disease.
Sonia Baldi, Angelamaria Becorpi.
Clin Cases Miner Bone Metab, 2009 Sep 01; 6(3). PMID: 22461256    Free PMC article.
Non-initiation of adjuvant hormonal therapy in women with hormone receptor-positive breast cancer: The Breast Cancer Quality of Care Study (BQUAL).
Alfred I Neugut, Grace Clarke Hillyer, +10 authors, Dawn L Hershman.
Breast Cancer Res Treat, 2012 Apr 25; 134(1). PMID: 22527111    Free PMC article.
MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
George C Bobustuc, Joshua S Smith, +10 authors, Santhi D Konduri.
Mol Med, 2012 May 03; 18. PMID: 22549111    Free PMC article.
Use of Adjuvant Endocrine Therapy in Postmenopausal Hormone Receptor-Positive Breast Cancer at German Breast Cancer Centers and University Hospitals - Results of an Enquiry (Adjuvant Endocrine Therapy Enquiry).
Thomas Kolben, Susanne Engelmann, Susanne Maurer, Martin Kolben.
Breast Care (Basel), 2012 May 04; 7(1). PMID: 22553471    Free PMC article.
Bilateral de quervain syndrome after aromatase inhibitor administration: a case report and review of the literature.
Konstantinos Papadimitriou, Panteleimon Kountourakis, +3 authors, Alexandros Ardavanis.
Case Rep Med, 2012 May 09; 2012. PMID: 22567020    Free PMC article.
Prevalence and risk factors for insomnia among breast cancer patients on aromatase inhibitors.
Krupali Desai, Jun J Mao, +4 authors, Philip R Gehrman.
Support Care Cancer, 2012 May 16; 21(1). PMID: 22584732    Free PMC article.
Exemestane for breast cancer prevention: a critical shift?
Andrea Decensi, Barbara K Dunn, +2 authors, Leslie G Ford.
Cancer Discov, 2012 May 16; 2(1). PMID: 22585166    Free PMC article.
Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: a systematic review.
Caitlin C Murphy, L Kay Bartholomew, +2 authors, Sally W Vernon.
Breast Cancer Res Treat, 2012 Jun 13; 134(2). PMID: 22689091    Free PMC article.
Highly Cited. Systematic Review.
Defining the aromatase inhibitor musculoskeletal syndrome: a prospective study.
Ora Singer, Tessa Cigler, +5 authors, Lisa A Mandl.
Arthritis Care Res (Hoboken), 2012 Jun 26; 64(12). PMID: 22730307    Free PMC article.
Patterns of bone density evaluation in a community population treated with aromatase inhibitors.
Jennifer A Ligibel, A James O'Malley, +3 authors, Nancy L Keating.
Breast Cancer Res Treat, 2012 Jul 14; 134(3). PMID: 22791365    Free PMC article.
Recent advances in adjuvant systemic treatment for breast cancer: all systems go!
P N Fishman, S Verma.
Curr Oncol, 2006 Oct 01; 13(5). PMID: 22792012    Free PMC article.
Fertility preservation in women with cancer.
Sanghoon Lee, Jae Yun Song, +2 authors, Tak Kim.
Clin Exp Reprod Med, 2012 Jul 21; 39(2). PMID: 22816069    Free PMC article.
Breast cancer chemoprevention: old and new approaches.
Massimiliano Cazzaniga, Bernardo Bonanni.
J Biomed Biotechnol, 2012 Aug 02; 2012. PMID: 22851887    Free PMC article.
The interaction between ER and NFκB in resistance to endocrine therapy.
Leen Sas, Filip Lardon, +5 authors, Steven J Van Laere.
Breast Cancer Res, 2012 Sep 12; 14(4). PMID: 22963717    Free PMC article.
Preventive therapy for breast cancer.
Ivana Sestak, Jack Cuzick.
Curr Oncol Rep, 2012 Sep 14; 14(6). PMID: 22972612
Impact of premenopausal status at breast cancer diagnosis in women entered on the placebo-controlled NCIC CTG MA17 trial of extended adjuvant letrozole.
P E Goss, J N Ingle, +11 authors, D Tu.
Ann Oncol, 2012 Oct 03; 24(2). PMID: 23028039    Free PMC article.
Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan.
Stephen Hiscox, Bedanta Baruha, +7 authors, Julia Gee.
BMC Cancer, 2012 Oct 09; 12. PMID: 23039365    Free PMC article.
Abrogating endocrine resistance by targeting ERα and PI3K in breast cancer.
Emily M Fox, Carlos L Arteaga, Todd W Miller.
Front Oncol, 2012 Oct 23; 2. PMID: 23087906    Free PMC article.
Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer.
Heather Greenlee, Katherine D Crew, +7 authors, Dawn L Hershman.
Support Care Cancer, 2012 Nov 01; 21(4). PMID: 23111941    Free PMC article.
The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.
Erik R Nelson, Suzanne E Wardell, Donald P McDonnell.
Bone, 2012 Nov 22; 53(1). PMID: 23168292    Free PMC article.
A DNA repair BRCA1 estrogen receptor and targeted therapy in breast cancer.
Adisorn Ratanaphan.
Int J Mol Sci, 2012 Dec 04; 13(11). PMID: 23203101    Free PMC article.
Online discussion of drug side effects and discontinuation among breast cancer survivors.
Jun J Mao, Annie Chung, +5 authors, John H Holmes.
Pharmacoepidemiol Drug Saf, 2013 Jan 17; 22(3). PMID: 23322591    Free PMC article.
Effectiveness of aromatase inhibitors and tamoxifen in reducing subsequent breast cancer.
Reina Haque, Syed A Ahmed, +5 authors, Joanne E Schottinger.
Cancer Med, 2013 Jan 24; 1(3). PMID: 23342281    Free PMC article.
Breast cancer: Tamoxifen--when more might be better.
Carlos Caldas, Ian F Tannock.
Nat Rev Clin Oncol, 2013 Feb 06; 10(3). PMID: 23380999
Influence of compliance on bone mineral density changes in postmenopausal women with early breast cancer on Anastrozole.
Matthias Kalder, Volker Ziller, +3 authors, Peyman Hadji.
J Cancer Res Clin Oncol, 2013 Feb 28; 139(6). PMID: 23443254
Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease.
Suzanne E Wardell, Erik R Nelson, Christina A Chao, Donald P McDonnell.
Clin Cancer Res, 2013 Mar 29; 19(9). PMID: 23536434    Free PMC article.
Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer.
N Lynn Henry, Todd C Skaar, +13 authors, David A Flockhart.
Breast Cancer Res Treat, 2013 Apr 03; 138(3). PMID: 23546553    Free PMC article.
Predictors of recovery of ovarian function during aromatase inhibitor therapy.
N L Henry, R Xia, +8 authors, D F Hayes.
Ann Oncol, 2013 Apr 25; 24(8). PMID: 23613476    Free PMC article.
Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer.
Nicola Napoli, Antonella Rastelli, +9 authors, Reina Armamento-Villareal.
Bone, 2013 May 07; 55(2). PMID: 23643682    Free PMC article.
Tumour dormancy and clinical implications in breast cancer.
L Gelao, C Criscitiello, +6 authors, G Curigliano.
Ecancermedicalscience, 2013 May 30; 7. PMID: 23717341    Free PMC article.
Prognosis in women with breast cancer and private extra insurance coverage.
Juan J Grau, Gabriel Zanon, +4 authors, Albert Biete.
Ann Surg Oncol, 2013 Jun 12; 20(9). PMID: 23754547    Free PMC article.
Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker.
Dennis C Sgroi, Erin Carney, +16 authors, Paul E Goss.
J Natl Cancer Inst, 2013 Jul 03; 105(14). PMID: 23812955    Free PMC article.
Pretreatment predictors of short-term nonadherence to oral hormonal therapy for women with breast cancer.
Karen E Wickersham, Susan M Sereika, Catherine M Bender.
Nurs Res, 2013 Jul 03; 62(4). PMID: 23817282    Free PMC article.
Combined effects of goserelin and tamoxifen on estradiol level, breast density, and endometrial thickness in premenopausal and perimenopausal women with early-stage hormone receptor-positive breast cancer: a randomised controlled clinical trial.
H Yang, X Zong, +17 authors, J Ni.
Br J Cancer, 2013 Jul 19; 109(3). PMID: 23860520    Free PMC article.
The predictive impact of body mass index on the efficacy of extended adjuvant endocrine treatment with anastrozole in postmenopausal patients with breast cancer: an analysis of the randomised ABCSG-6a trial.
M Gnant, G Pfeiler, +12 authors, R Jakesz.
Br J Cancer, 2013 Jul 23; 109(3). PMID: 23868011    Free PMC article.
Luminal breast cancer: from biology to treatment.
Michail Ignatiadis, Christos Sotiriou.
Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035
Indications of clinical and genetic predictors for aromatase inhibitors related musculoskeletal adverse events in Chinese Han women with breast cancer.
Jingxuan Wang, Kangping Lu, +12 authors, Qingyuan Zhang.
PLoS One, 2013 Jul 31; 8(7). PMID: 23894347    Free PMC article.
Understanding cardiovascular injury after treatment for cancer: an overview of current uses and future directions of cardiovascular magnetic resonance.
Sujethra Vasu, W Gregory Hundley.
J Cardiovasc Magn Reson, 2013 Aug 02; 15. PMID: 23902649    Free PMC article.
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013.
A Goldhirsch, E P Winer, +5 authors, Panel members.
Ann Oncol, 2013 Aug 07; 24(9). PMID: 23917950    Free PMC article.
Highly Cited.
Scientific rationale for postmenopause delay in the use of conjugated equine estrogens among postmenopausal women that causes reduction in breast cancer incidence and mortality.
Ifeyinwa Obiorah, V Craig Jordan.
Menopause, 2013 Aug 08; 20(4). PMID: 23921472    Free PMC article.
A polymorphism at the 3'-UTR region of the aromatase gene is associated with the efficacy of the aromatase inhibitor, anastrozole, in metastatic breast carcinoma.
Lei Liu, Yu-Xian Bai, +12 authors, Qing-Yuan Zhang.
Int J Mol Sci, 2013 Sep 26; 14(9). PMID: 24065098    Free PMC article.
Breast cancer management in the elderly.
M Luque, F Arranz, +9 authors, Y Fernández.
Clin Transl Oncol, 2013 Oct 03; 16(4). PMID: 24085574
HDAC inhibitor entinostat restores responsiveness of letrozole-resistant MCF-7Ca xenografts to aromatase inhibitors through modulation of Her-2.
Gauri J Sabnis, Olga G Goloubeva, +2 authors, Angela H Brodie.
Molecular cancer therapeutics, 2013 Oct 05; 12(12). PMID: 24092810    Free PMC article.
Endogenous estradiol is not associated with poor physical health in postmenopausal breast cancer survivors.
H Irene Su, Laura Y Sue, +3 authors, John P Pierce.
J Womens Health (Larchmt), 2013 Oct 12; 22(12). PMID: 24111813    Free PMC article.
Early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients.
Kenji Taketani, Eriko Tokunaga, +10 authors, Yoshihiko Maehara.
Surg Today, 2013 Oct 22; 44(10). PMID: 24142101    Free PMC article.
The EndoPredict score provides prognostic information on late distant metastases in ER+/HER2- breast cancer patients.
P Dubsky, J C Brase, +18 authors, Austrian Breast and Colorectal Cancer Study Group (ABCSG).
Br J Cancer, 2013 Oct 26; 109(12). PMID: 24157828    Free PMC article.
Highly Cited.
Aromatase inhibitor associated musculoskeletal symptoms are associated with reduced physical activity among breast cancer survivors.
Justin C Brown, Jun J Mao, +3 authors, Kathryn H Schmitz.
Breast J, 2013 Oct 30; 20(1). PMID: 24165356    Free PMC article.
Oestrogen receptors in breast cancer: basic mechanisms and clinical implications.
Cecilia Williams, Chin-Yo Lin.
Ecancermedicalscience, 2013 Nov 14; 7. PMID: 24222786    Free PMC article.
Expression of estrogen-related gene markers in breast cancer tissue predicts aromatase inhibitor responsiveness.
Irene Moy, Zhihong Lin, +3 authors, Serdar E Bulun.
PLoS One, 2013 Nov 14; 8(11). PMID: 24223121    Free PMC article.
An unmet need: tailoring extended adjuvant endocrine therapy.
G Bianchini, L Gianni.
Br J Cancer, 2013 Nov 21; 109(12). PMID: 24253504    Free PMC article.
Current and emerging treatment strategies for breast cancer-induced bone loss.
Stephanie L Hines.
Breast Cancer (Dove Med Press), 2010 Jan 01; 2. PMID: 24367168    Free PMC article.
Complementary or alternative medicine as possible determinant of decreased persistence to aromatase inhibitor therapy among older women with non-metastatic breast cancer.
Laetitia Huiart, Anne-Deborah Bouhnik, +6 authors, Roch Giorgi.
PLoS One, 2013 Dec 25; 8(12). PMID: 24367488    Free PMC article.
The optimal duration of adjuvant endocrine therapy for early stage breast cancer--with what drugs and for how long?
Stephen R D Johnston, Belinda Yeo.
Curr Oncol Rep, 2014 Jan 07; 16(1). PMID: 24390724
Breast cancer follow-up strategies in randomized phase III adjuvant clinical trials: a systematic review.
Isabella Sperduti, Patrizia Vici, +6 authors, Clara Natoli.
J Exp Clin Cancer Res, 2014 Jan 21; 32. PMID: 24438135    Free PMC article.
Systematic Review.
Adherence to adjuvant endocrine therapy in estrogen receptor-positive breast cancer patients with regular follow-up.
Renée Simon, Jean Latreille, +2 authors, Eric Bergeron.
Can J Surg, 2014 Jan 28; 57(1). PMID: 24461223    Free PMC article.
Clinical impact of delaying initiation of adjuvant chemotherapy in patients with breast cancer.
Debora de Melo Gagliato, Ana M Gonzalez-Angulo, +5 authors, Mariana Chavez-Macgregor.
J Clin Oncol, 2014 Jan 29; 32(8). PMID: 24470007    Free PMC article.
A joint test for progression and survival with interval-censored data from a cancer clinical trial.
Dianne M Finkelstein, David A Schoenfeld.
Stat Med, 2014 Feb 07; 33(12). PMID: 24500790    Free PMC article.
Clinical utility of aromatase inhibitors as adjuvant treatment in postmenopausal early breast cancer.
Arturo Loaiza-Bonilla, Francisco Socola, Stefan Glück.
Clin Med Insights Womens Health, 2013 Jan 01; 6. PMID: 24665209    Free PMC article.
Breast cancer "tailored follow-up" in Italian oncology units: a web-based survey.
Clara Natoli, Davide Brocco, +9 authors, “FOLLOW-UP” Study Group.
PLoS One, 2014 Apr 10; 9(4). PMID: 24714591    Free PMC article.
Second malignancies after breast cancer: The impact of adjuvant therapy.
Chunhui Dong, Ling Chen.
Mol Clin Oncol, 2014 Apr 29; 2(3). PMID: 24772296    Free PMC article.
Current strategies for the prevention of breast cancer.
Pooja Advani, Alvaro Moreno-Aspitia.
Breast Cancer (Dove Med Press), 2014 May 17; 6. PMID: 24833917    Free PMC article.
Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: american society of clinical oncology clinical practice guideline focused update.
Harold J Burstein, Sarah Temin, +10 authors, Jennifer J Griggs.
J Clin Oncol, 2014 May 29; 32(21). PMID: 24868023    Free PMC article.
Highly Cited.
Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: a study protocol for a multicenter, randomized, controlled clinical trial.
Nan Peng, Yi Zhang, +5 authors, Xiao-Min Wang.
Trials, 2014 Jun 03; 15. PMID: 24885324    Free PMC article.
Status of adjuvant endocrine therapy for breast cancer.
Gaia Schiavon, Ian E Smith.
Breast Cancer Res, 2014 Jul 18; 16(2). PMID: 25032258    Free PMC article.
Effects of psoralens as anti-tumoral agents in breast cancer cells.
Maria Luisa Panno, Francesca Giordano.
World J Clin Oncol, 2014 Aug 13; 5(3). PMID: 25114850    Free PMC article.
AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2014.
Cornelia Liedtke, Marc Thill, +2 authors, AGO Breast Committee.
Breast Care (Basel), 2014 Sep 02; 9(3). PMID: 25177261    Free PMC article.
Effects of switching from anastrozole to letrozole, due to reimbursement policy, on the outcome of breast cancer therapy.
Potchavit Aphinives, Damnern Vachirodom, +2 authors, Ongart Somintara.
Breast Cancer (Dove Med Press), 2014 Sep 25; 6. PMID: 25249759    Free PMC article.
Time dependence of biomarkers: non-proportional effects of immunohistochemical panels predicting relapse risk in early breast cancer.
J Stephen, G Murray, +13 authors, J M S Bartlett.
Br J Cancer, 2014 Oct 15; 111(12). PMID: 25314051    Free PMC article.
Preventative therapies for healthy women at high risk of breast cancer.
Ivana Sestak.
Cancer Manag Res, 2014 Nov 08; 6. PMID: 25378950    Free PMC article.
The Mediating Effects of Self-Esteem and Optimism on the Relationship between Quality of Life and Depressive Symptoms of Breast Cancer Patients.
Eun Hye Ha, Young Kyung Cho.
Psychiatry Investig, 2014 Nov 15; 11(4). PMID: 25395975    Free PMC article.
Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors.
Melinda L Irwin, Brenda Cartmel, +13 authors, Jennifer Ligibel.
J Clin Oncol, 2014 Dec 03; 33(10). PMID: 25452437    Free PMC article.
Evaluation of Therapy Management and Patient Compliance in Postmenopausal Patients with Hormone Receptor-positive Breast Cancer Receiving Letrozole Treatment: The EvaluateTM Study.
P A Fasching, T Fehm, +47 authors, S Y Brucker.
Geburtshilfe Frauenheilkd, 2015 Jan 09; 74(12). PMID: 25568468    Free PMC article.
A comparison of letrozole and anastrozole followed by letrozole in breast cancer patients.
Potchavit Aphinives, Damnern Vachirodom, +2 authors, Ongart Somintara.
Breast Cancer (Dove Med Press), 2015 Feb 06; 7. PMID: 25653555    Free PMC article.
Fertility preservation and breast cancer: a review.
María de Pedro, Borja Otero, Belén Martín.
Ecancermedicalscience, 2015 Mar 03; 9. PMID: 25729416    Free PMC article.
Aromatase inhibitors, tamoxifen, and endometrial cancer in breast cancer survivors.
Rowan T Chlebowski, Joanne E Schottinger, +2 authors, Reina Haque.
Cancer, 2015 Mar 12; 121(13). PMID: 25757699    Free PMC article.
Timing of adjuvant surgical oophorectomy in the menstrual cycle and disease-free and overall survival in premenopausal women with operable breast cancer.
Richard R Love, Adriano V Laudico, +18 authors, David Jarjoura.
J Natl Cancer Inst, 2015 Mar 22; 107(6). PMID: 25794890    Free PMC article.
Adjuvant endocrine therapy for early breast cancer: a systematic review of the evidence for the 2014 Cancer Care Ontario systemic therapy guideline.
O C Freedman, G G Fletcher, +4 authors, A Eisen.
Curr Oncol, 2015 Apr 08; 22(Suppl 1). PMID: 25848344    Free PMC article.
Economic evaluation of hormonal therapies for postmenopausal women with estrogen receptor-positive early breast cancer in Canada.
S Djalalov, J Beca, +3 authors, J S Hoch.
Curr Oncol, 2015 Apr 25; 22(2). PMID: 25908907    Free PMC article.
Acupuncture for treating aromatase inhibitor-related arthralgia in breast cancer: a systematic review and meta-analysis.
Tsai-Ju Chien, Chia-Yu Liu, +2 authors, Chung-Hua Hsu.
J Altern Complement Med, 2015 Apr 29; 21(5). PMID: 25915433    Free PMC article.
Systematic Review.
5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial.
Nina D Wagner-Johnston, Jeff A Sloan, +7 authors, Charles L Loprinzi.
Cancer, 2015 May 02; 121(15). PMID: 25930719    Free PMC article.
The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy.
Ping Fan, Philipp Y Maximov, +2 authors, V Craig Jordan.
Mol Cell Endocrinol, 2015 Jun 09; 418 Pt 3. PMID: 26052034    Free PMC article.
Clinical utility of exemestane in the treatment of breast cancer.
Giorgia Zucchini, Elena Geuna, +3 authors, Filippo Montemurro.
Int J Womens Health, 2015 Jun 13; 7. PMID: 26064072    Free PMC article.
Influence of CYP19A1 polymorphisms on the treatment of breast cancer with aromatase inhibitors: a systematic review and meta-analysis.
Osvaldo Artigalás, Tazio Vanni, +2 authors, Ida Vanessa Schwartz.
BMC Med, 2015 Jun 13; 13. PMID: 26067721    Free PMC article.
Systematic Review.
Methods to Standardize a Multicenter Acupuncture Trial Protocol to Reduce Aromatase Inhibitor-related Joint Symptoms in Breast Cancer Patients.
Heather Greenlee, Katherine D Crew, +8 authors, Dawn L Hershman.
J Acupunct Meridian Stud, 2015 Jun 24; 8(3). PMID: 26100070    Free PMC article.
Fracture risk and adjuvant therapies in young breast cancer patients: a population-based study.
Chun-Hung Chang, Shaw-Ji Chen, Chieh-Yu Liu.
PLoS One, 2015 Jun 25; 10(6). PMID: 26107848    Free PMC article.
Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia?
Joshua Bauml, Lu Chen, +5 authors, Jun J Mao.
Breast Cancer Res, 2015 Jul 02; 17. PMID: 26126656    Free PMC article.
Adjuvant therapy use among Appalachian breast cancer survivors.
Xi Tan, Vincent D Marshall, +3 authors, Rajesh Balkrishnan.
Medicine (Baltimore), 2015 Jul 02; 94(26). PMID: 26131828    Free PMC article.
Application status of tamoxifen in endocrine therapy for early breast cancer.
Qiancheng Hu, Ting Luo, +3 authors, Hong Zheng.
Exp Ther Med, 2015 Jul 03; 9(6). PMID: 26136961    Free PMC article.
Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?
Wilbert Zwart, Huub Terra, Sabine C Linn, Sanne B Schagen.
Nat Rev Clin Oncol, 2015 Jul 22; 12(10). PMID: 26196252
Adjuvant endocrine therapy in pre- versus postmenopausal patients with steroid hormone receptor-positive breast cancer: results from a large population-based cohort of a cancer registry.
E C Inwald, M Koller, +7 authors, O Ortmann.
J Cancer Res Clin Oncol, 2015 Aug 09; 141(12). PMID: 26253629    Free PMC article.
Progress in adjuvant chemotherapy for breast cancer: an overview.
Jesus Anampa, Della Makower, Joseph A Sparano.
BMC Med, 2015 Aug 19; 13. PMID: 26278220    Free PMC article.
Highly Cited. Review.
Fertility preservation in reproductive-age women facing gonadotoxic treatments.
J Roberts, R Ronn, N Tallon, H Holzer.
Curr Oncol, 2015 Aug 25; 22(4). PMID: 26300680    Free PMC article.
Hormone Replacement Therapy, Likely Neither Angel Nor Demon.
Mitchell S Wachtel, Shengping Yang, Sharmila Dissanaike, Julie A Margenthaler.
PLoS One, 2015 Sep 19; 10(9). PMID: 26384022    Free PMC article.
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.
Joseph A Sparano, Robert J Gray, +28 authors, George W Sledge.
N Engl J Med, 2015 Sep 29; 373(21). PMID: 26412349    Free PMC article.
Highly Cited.
Statistical controversies in clinical research: long-term follow-up of clinical trials in cancer.
J Cuzick.
Ann Oncol, 2015 Oct 05; 26(12). PMID: 26433395    Free PMC article.
The Globalization of Cooperative Groups.
Manuel Valdivieso, Benjamin W Corn, +8 authors, Charles D Blanke.
Semin Oncol, 2015 Oct 05; 42(5). PMID: 26433551    Free PMC article.
Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem.
Fotinos-Ioannis D Dimitrakopoulos, Anastasia Kottorou, +2 authors, Haralabos P Kalofonos.
J Breast Cancer, 2015 Oct 17; 18(3). PMID: 26472970    Free PMC article.
Prospective assessment of the decision-making impact of the Breast Cancer Index in recommending extended adjuvant endocrine therapy for patients with early-stage ER-positive breast cancer.
Tara Sanft, Bilge Aktas, +11 authors, Lajos Pusztai.
Breast Cancer Res Treat, 2015 Nov 19; 154(3). PMID: 26578401    Free PMC article.
Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.
Debashis Ghosh, Jessica Lo, Chinaza Egbuta.
J Med Chem, 2015 Dec 23; 59(11). PMID: 26689671    Free PMC article.
Changing Paradigms in Breast Cancer Therapeutics: An Extended Abstract.
Jo Anne Zujewski.
Med Princ Pract, 2015 Dec 23; 25 Suppl 2. PMID: 26690956    Free PMC article.
Adjuvant treatment for older women with invasive breast cancer.
Trevor A Jolly, Grant R Williams, +4 authors, Hyman B Muss.
Womens Health (Lond), 2016 Jan 16; 12(1). PMID: 26767315    Free PMC article.
Tamoxifen Initiation After Ductal Carcinoma In Situ.
Hazel B Nichols, Erin J A Bowles, +4 authors, Diana S M Buist.
Oncologist, 2016 Jan 16; 21(2). PMID: 26768485    Free PMC article.
Adjuvant hormonal therapy in premenopausal women with breast cancer.
Lillian Smyth, Clifford Hudis.
Indian J Med Paediatr Oncol, 2016 Jan 27; 36(4). PMID: 26811586    Free PMC article.
Assessing survival benefit when treatment delays disease progression.
David A Schoenfeld, Dianne M Finkelstein.
Clin Trials, 2016 Feb 26; 13(3). PMID: 26908538    Free PMC article.
Estimation of drug cost avoidance and pathology cost avoidance through participation in NCIC Clinical Trials Group phase III clinical trials in Canada.
P A Tang, A E Hay, +4 authors, N B Leighl.
Curr Oncol, 2016 Mar 18; 23(Suppl 1). PMID: 26985151    Free PMC article.
Clinical utility of letrozole in the treatment of breast cancer: a Chinese perspective.
Dong-Xu He, Xin Ma.
Onco Targets Ther, 2016 Apr 05; 9. PMID: 27042100    Free PMC article.
Psychosocial factors related to non-persistence with adjuvant endocrine therapy among women with breast cancer: the Breast Cancer Quality of Care Study (BQUAL).
Dawn L Hershman, Lawrence H Kushi, +10 authors, Alfred I Neugut.
Breast Cancer Res Treat, 2016 Apr 18; 157(1). PMID: 27086286    Free PMC article.
Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer.
Denise A Yardley.
Breast Cancer (Dove Med Press), 2016 May 25; 8. PMID: 27217795    Free PMC article.
Evaluating the Survival Benefit Following Ovarian Function Suppression in Premenopausal Patients with Hormone Receptor Positive Early Breast Cancer.
Lin Qiu, Fangmeng Fu, +4 authors, Chuan Wang.
Sci Rep, 2016 May 28; 6. PMID: 27230285    Free PMC article.
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years.
Paul E Goss, James N Ingle, +17 authors, Wendy R Parulekar.
N Engl J Med, 2016 Jun 07; 375(3). PMID: 27264120    Free PMC article.
Highly Cited.
Challenges in translating endpoints from trials to observational cohort studies in oncology.
Anne Gulbech Ording, Deirdre Cronin-Fenton, +4 authors, Henrik Toft Sørensen.
Clin Epidemiol, 2016 Jun 30; 8. PMID: 27354827    Free PMC article.
The PI3K inhibitor taselisib overcomes letrozole resistance in a breast cancer model expressing aromatase.
Klaus P Hoeflich, Jane Guan, +6 authors, Jeffrey J Wallin.
Genes Cancer, 2016 Jul 07; 7(3-4). PMID: 27382432    Free PMC article.
Factors associated with late recurrence after completion of 5-year adjuvant tamoxifen in estrogen receptor positive breast cancer.
Eun-Shin Lee, Wonshik Han, +9 authors, Eun Sook Lee.
BMC Cancer, 2016 Jul 09; 16. PMID: 27388210    Free PMC article.
From High-Throughput Microarray-Based Screening to Clinical Application: The Development of a Second Generation Multigene Test for Breast Cancer Prognosis.
Jan C Brase, Ralf Kronenwett, +2 authors, Marcus Schmidt.
Microarrays (Basel), 2013 Jan 01; 2(3). PMID: 27605191    Free PMC article.
Geographic disparities in adherence to adjuvant endocrine therapy in Appalachian women with breast cancer.
Xi Tan, Fabian Camacho, +3 authors, Rajesh Balkrishnan.
Res Social Adm Pharm, 2016 Sep 20; 13(4). PMID: 27641308    Free PMC article.
[Multimodal imaging of breast cancer recurrence : Prospective intraindividual comparison of 18F-FDG PET/CT, contrast-enhanced CT, and bone scintigraphy].
M Avanesov, T Derlin.
Radiologe, 2016 Oct 21; 57(1). PMID: 27757490
Cardiotoxicity of aromatase inhibitors and tamoxifen in postmenopausal women with breast cancer: a systematic review and meta-analysis of randomized controlled trials.
F Khosrow-Khavar, K B Filion, +4 authors, L Azoulay.
Ann Oncol, 2016 Dec 22; 28(3). PMID: 27998966    Free PMC article.
Systematic Review.
Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo.
Laura E Wright, Ahmed A Harhash, +9 authors, Theresa A Guise.
Oncotarget, 2017 Jan 01; 8(5). PMID: 28039445    Free PMC article.
Immunohistochemical determination of estrogen and progesterone receptors in breast cancer: relationship with clinicopathologic factors in 302 patients in Ivory Coast.
Ahoua Benjamin Effi, Nguiessan Alphonse Aman, +3 authors, Mohamed Kouyate.
BMC Cancer, 2017 Feb 09; 17(1). PMID: 28173783    Free PMC article.
Traditional Chinese Medicine Bionic Tiger Bone Powder for the Treatment of AI-Associated Musculoskeletal Symptoms.
Yifan Li, Zhenhua Zhang, +5 authors, Wenping Lu.
Evid Based Complement Alternat Med, 2017 Mar 03; 2017. PMID: 28250792    Free PMC article.
Extended Endocrine Therapy: Is 5 Years Enough?
Manali A Bhave, N Lynn Henry.
Curr Oncol Rep, 2017 Mar 03; 19(3). PMID: 28251491
Embryonic transcription factor SOX9 drives breast cancer endocrine resistance.
Rinath Jeselsohn, MacIntosh Cornwell, +20 authors, Myles Brown.
Proc Natl Acad Sci U S A, 2017 May 17; 114(22). PMID: 28507152    Free PMC article.
Clinical utility of gene-expression signatures in early stage breast cancer.
Maryann Kwa, Andreas Makris, Francisco J Esteva.
Nat Rev Clin Oncol, 2017 Jun 01; 14(10). PMID: 28561071
Highly Cited. Review.
Randomized phase II placebo-controlled study to evaluate the efficacy of topical pure emu oil for joint pain related to adjuvant aromatase inhibitor use in postmenopausal women with early breast cancer: JUST (Joints Under Study).
Arlene Chan, R De Boer, +6 authors, D Hastrich.
Support Care Cancer, 2017 Jul 12; 25(12). PMID: 28691132
Randomized trial of medroxyprogesterone acetate for the prevention of endometrial pathology from adjuvant tamoxifen for breast cancer: SWOG S9630.
Ronald K Potkul, Joseph M Unger, +13 authors, Kathy S Albain.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721383    Free PMC article.
Risk factors of pain in breast cancer survivors: a systematic review and meta-analysis.
Laurence Leysen, David Beckwée, +4 authors, Nele Adriaenssens.
Support Care Cancer, 2017 Aug 12; 25(12). PMID: 28799015
Systematic Review.
Magnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers.
Ji Soo Choi, Dahye Yoon, +5 authors, Min Jung Kim.
Oncotarget, 2017 Oct 04; 8(38). PMID: 28969000    Free PMC article.
Use of 21-gene recurrence score assay to individualize adjuvant chemotherapy recommendations in ER+/HER2- node positive breast cancer-A National Cancer Database study.
Prema P Peethambaram, Tanya L Hoskin, +3 authors, Judy C Boughey.
NPJ Breast Cancer, 2017 Oct 27; 3. PMID: 29067357    Free PMC article.
Effect of denosumab administration on low bone mineral density (T-score -1.0 to -2.5) in postmenopausal Japanese women receiving adjuvant aromatase inhibitors for non-metastatic breast cancer.
Katsuhiko Nakatsukasa, Hiroshi Koyama, +6 authors, Tetsuya Taguchi.
J Bone Miner Metab, 2017 Nov 09; 36(6). PMID: 29116414
20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.
Hongchao Pan, Richard Gray, +9 authors, EBCTCG.
N Engl J Med, 2017 Nov 09; 377(19). PMID: 29117498    Free PMC article.
Highly Cited.
A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.
Philipp Y Maximov, Balkees Abderrahman, +3 authors, V Craig Jordan.
Endocr Relat Cancer, 2017 Nov 23; 25(2). PMID: 29162647    Free PMC article.
Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES.
M C U Cheang, J M Bliss, +13 authors, PathIES Sub-Committee.
Breast Cancer Res Treat, 2017 Nov 28; 168(1). PMID: 29177605    Free PMC article.
Relevant factors for the optimal duration of extended endocrine therapy in early breast cancer.
Erik J Blok, Judith R Kroep, +8 authors, IDEAL Study Group.
Breast Cancer Res Treat, 2017 Dec 13; 168(2). PMID: 29230665    Free PMC article.
Optimal duration of adjuvant endocrine therapy: how to apply the newest data.
Kerstin Wimmer, Stephanie Strobl, +5 authors, Michael Gnant.
Ther Adv Med Oncol, 2018 Jan 19; 9(11). PMID: 29344105    Free PMC article.
Luminal-like HER2-negative stage IA breast cancer: a multicenter retrospective study on long-term outcome with propensity score analysis.
Carmine De Angelis, Massimo Di Maio, +12 authors, Grazia Arpino.
Oncotarget, 2018 Jan 20; 8(68). PMID: 29348868    Free PMC article.
Cancer Treatment and Bone Health.
Catherine Handforth, Stella D'Oronzo, Robert Coleman, Janet Brown.
Calcif Tissue Int, 2018 Jan 22; 102(2). PMID: 29353450    Free PMC article.
Psychometric properties of the Beliefs about Medicine Questionnaire-adjuvant endocrine therapy (BMQ-AET) for women taking AETs following early-stage breast cancer.
Jo Brett, Nick J Hulbert-Williams, +8 authors, Eila Watson.
Health Psychol Open, 2018 Jan 31; 4(2). PMID: 29379627    Free PMC article.
Extended Adjuvant Aromatase Inhibitor Therapy in Post-Menopausal Women.
Stephen M Schleicher, Maura N Dickler.
Curr Breast Cancer Rep, 2018 Feb 06; 9(4). PMID: 29399271    Free PMC article.
Aromatase inhibitors are associated with a higher fracture risk than tamoxifen: a systematic review and meta-analysis.
Olivia L Tseng, John J Spinelli, +3 authors, Martin G Dawes.
Ther Adv Musculoskelet Dis, 2018 Apr 06; 10(4). PMID: 29619093    Free PMC article.
Practical consensus recommendations on ovarian suppression in early breast cancer (adjuvant).
M Singhal, T P Sahoo, +8 authors, Purvish M Parikh.
South Asian J Cancer, 2018 May 04; 7(2). PMID: 29721484    Free PMC article.
Arterial Stiffness in Breast Cancer Patients Treated with Anthracycline and Trastuzumab-Based Regimens.
Özlem Yersal, Ufuk Eryilmaz, +2 authors, Sabri Barutca.
Cardiol Res Pract, 2018 Jun 02; 2018. PMID: 29854434    Free PMC article.
Interventional Cardio-Oncology: Adding a New Dimension to the Cardio-Oncology Field.
Victor Y Liu, Ali M Agha, +8 authors, Cezar A Iliescu.
Front Cardiovasc Med, 2018 Jun 06; 5. PMID: 29868614    Free PMC article.
Clinical application and utility of genomic assays in early-stage breast cancer: key lessons learned to date.
S K L Chia.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910655    Free PMC article.
Optimal management of luminal breast cancer: how much endocrine therapy is long enough?
Elisabetta Munzone, Marco Colleoni.
Ther Adv Med Oncol, 2018 Jul 07; 10. PMID: 29977350    Free PMC article.
Endocrine therapy for breast cancer in the primary care setting.
A Awan, K Esfahani.
Curr Oncol, 2018 Aug 17; 25(4). PMID: 30111969    Free PMC article.
Novel 18-gene signature for predicting relapse in ER-positive, HER2-negative breast cancer.
Richard Buus, Belinda Yeo, +7 authors, Mitch Dowsett.
Breast Cancer Res, 2018 Sep 06; 20(1). PMID: 30180877    Free PMC article.
The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast.
Hugo Villanueva, Sandra Grimm, +7 authors, Dean P Edwards.
J Mammary Gland Biol Neoplasia, 2018 Oct 20; 23(4). PMID: 30338425    Free PMC article.
Extended duration of adjuvant aromatase inhibitor in breast cancer: a meta-analysis of randomized controlled trials.
Zackariah Clement, James Kollias, +2 authors, Melissa Bochner.
Gland Surg, 2018 Dec 07; 7(5). PMID: 30505766    Free PMC article.
Prediction of Late Breast Cancer-Specific Mortality in Recurrence-Free Breast Cancer Survivors Treated for Five Years with Tamoxifen.
Soo Yeon Baek, Ji Yeong Kwon, +12 authors, Jong Won Lee.
J Breast Cancer, 2019 Oct 11; 22(3). PMID: 31598339    Free PMC article.
The duration of endocrine therapy and breast cancer patients' survival: A nationwide population-based cohort study.
Chuan-Hsun Chang, Chun-Wen Huang, +3 authors, You-Min Lu.
Medicine (Baltimore), 2019 Oct 28; 98(43). PMID: 31651908    Free PMC article.
A Rare Case of Triple Positive Metachronous Breast Cancer.
Hardik S Chhatrala, John Khuu, Lara Zuberi.
J Investig Med High Impact Case Rep, 2019 Dec 21; 7. PMID: 31858813    Free PMC article.
Rheumatological Findings in Patients with Breast Cancer.
Figen Tarhan, Gökhan Keser, Ahmet Alacacıoğlu, Servet Akar.
Eur J Breast Health, 2020 Jan 09; 16(1). PMID: 31912015    Free PMC article.
Successful Targeted Therapies for Breast Cancer: the Worcester Foundation and Future Opportunities in Women's Health.
Balkees Abderrahman, V Craig Jordan.
Endocrinology, 2018 Jun 23; 159(8). PMID: 29931061    Free PMC article.
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2019 Jun 04; 380(25). PMID: 31157962    Free PMC article.
Highly Cited.
Association of Circulating Tumor Cells With Late Recurrence of Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Joseph Sparano, Anne O'Neill, +5 authors, Kathy D Miller.
JAMA Oncol, 2018 Jul 29; 4(12). PMID: 30054636    Free PMC article.
Highly Cited.
Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression.
Priya Bhardwaj, CheukMan C Au, +4 authors, Kristy A Brown.
J Steroid Biochem Mol Biol, 2019 Mar 10; 189. PMID: 30851382    Free PMC article.
Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial.
Karin Ribi, Weixiu Luo, +27 authors, SOLE Investigators.
Br J Cancer, 2019 Apr 11; 120(10). PMID: 30967649    Free PMC article.
Nintedanib plus letrozole in early breast cancer: a phase 0/I pharmacodynamic, pharmacokinetic, and safety clinical trial of combined FGFR1 and aromatase inhibition.
Miguel Quintela-Fandino, Juan V Apala, +5 authors, Juan Guerra.
Breast Cancer Res, 2019 May 28; 21(1). PMID: 31126332    Free PMC article.
Impact of Somatic Yoga and Meditation on Fall Risk, Function, and Quality of Life for Chemotherapy-Induced Peripheral Neuropathy Syndrome in Cancer Survivors.
Mary Lou Galantino, Robyn Tiger, +2 authors, Kim Wilson.
Integr Cancer Ther, 2019 May 28; 18. PMID: 31131640    Free PMC article.
Aromatase Inhibitors and Newly Developed Nonalcoholic Fatty Liver Disease in Postmenopausal Patients with Early Breast Cancer: A Propensity Score-Matched Cohort Study.
Jung Il Lee, Jung-Hwan Yu, +3 authors, Kwan Sik Lee.
Oncologist, 2019 Jan 27; 24(8). PMID: 30679317    Free PMC article.
Use of letrozole after aromatase inhibitor-based therapy in postmenopausal breast cancer (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled, phase 3 trial.
Eleftherios P Mamounas, Hanna Bandos, +17 authors, Norman Wolmark.
Lancet Oncol, 2018 Dec 05; 20(1). PMID: 30509771    Free PMC article.
Acupuncture and Vitamin D for the Management of Aromatase Inhibitor-Induced Arthralgia.
Kartik Anand, Polly Niravath.
Curr Oncol Rep, 2019 Apr 19; 21(6). PMID: 30997616
Management of hormone receptor-positive, HER2-negative early breast cancer.
Elaine M Walsh, Karen L Smith, Vered Stearns.
Semin Oncol, 2020 Jun 18; 47(4). PMID: 32546323    Free PMC article.
Application of the ESMO-Magnitude of Clinical Benefit Scale (V.1.1) to the field of early breast cancer therapies.
Shani Paluch-Shimon, Nathan I Cherny, +4 authors, Fatima Cardoso.
ESMO Open, 2020 Sep 08; 5(5). PMID: 32893189    Free PMC article.
Endocrine and Targeted Therapy for Hormone-Receptor-Positive, HER2-Negative Advanced Breast Cancer: Insights to Sequencing Treatment and Overcoming Resistance Based on Clinical Trials.
Rola El Sayed, Lara El Jamal, +3 authors, Hazem Assi.
Front Oncol, 2019 Jul 10; 9. PMID: 31281796    Free PMC article.
Individualized Chemotherapy Benefit Prediction by EndoPredict in Patients With Early Breast Cancer in an Indian Cohort.
S P Somashekhar, Shabber Zaveri, +4 authors, Charu Bahl.
JCO Glob Oncol, 2020 Sep 09; 6. PMID: 32897733    Free PMC article.
Delayed initiation of adjuvant chemotherapy in older women with breast cancer.
Demetria Smith-Graziani, Xiudong Lei, +3 authors, Mariana Chavez-MacGregor.
Cancer Med, 2020 Aug 09;. PMID: 32767723    Free PMC article.
ARe we there yet? Understanding androgen receptor signaling in breast cancer.
Anna R Michmerhuizen, Daniel E Spratt, Lori J Pierce, Corey W Speers.
NPJ Breast Cancer, 2020 Oct 17; 6. PMID: 33062889    Free PMC article.
Analysis of the serial circulating tumor cell count during neoadjuvant chemotherapy in breast cancer patients.
Sung-Chan Gwark, Jisun Kim, +23 authors, Sei Hyun Ahn.
Sci Rep, 2020 Oct 17; 10(1). PMID: 33060768    Free PMC article.