Review
. 2003 Dec; 3(12):939-51.
doi: 10.1038/nri1248.

CD28-mediated co-stimulation: a quantitative support for TCR signalling

Oreste Acuto 1 Frédérique Michel  
Affiliations
  • PMID: 14647476
  •     246 citations

No abstract available

T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective.
E C Jury, P S Kabouridis.
Lupus, 2004 Aug 12; 13(6). PMID: 15303567    Free PMC article.
Review.
Hyperresponse to T-cell receptor signaling and apoptosis of Id1 transgenic thymocytes.
Zengbiao Qi, Xiao-Hong Sun.
Mol Cell Biol, 2004 Aug 18; 24(17). PMID: 15314144    Free PMC article.
Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy.
Daniel J Powell, Mark E Dudley, Paul F Robbins, Steven A Rosenberg.
Blood, 2004 Sep 04; 105(1). PMID: 15345595    Free PMC article.
CD28 costimulation is required for the expression of T-cell-dependent cell-mediated immunity against blood-stage Plasmodium chabaudi malaria parasites.
Thomas Rummel, Joan Batchelder, +4 authors, William P Weidanz.
Infect Immun, 2004 Sep 24; 72(10). PMID: 15385476    Free PMC article.
Calcium-dependent activation of T-lymphocytes.
Ariel Quintana, Désirée Griesemer, Eva C Schwarz, Markus Hoth.
Pflugers Arch, 2005 Apr 05; 450(1). PMID: 15806400
Review.
Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?
Vivianne Malmström, Christina Trollmo, Lars Klareskog.
Arthritis Res Ther, 2005 Apr 19; 7 Suppl 2. PMID: 15833144    Free PMC article.
Review.
CD28 costimulatory signal induces protein arginine methylation in T cells.
Fabien Blanchet, Ana Cardona, +2 authors, Oreste Acuto.
J Exp Med, 2005 Aug 03; 202(3). PMID: 16061726    Free PMC article.
Co-stimulatory blockade as therapy for rheumatoid arthritis.
Sarah L Mackie, Edward M Vital, Frederique Ponchel, Paul Emery.
Curr Rheumatol Rep, 2005 Sep 22; 7(5). PMID: 16174492
Review.
Condensation of the plasma membrane at the site of T lymphocyte activation.
Katharina Gaus, Elena Chklovskaia, +2 authors, Thomas Harder.
J Cell Biol, 2005 Oct 06; 171(1). PMID: 16203859    Free PMC article.
Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases.
N Beyersdorf, T Hanke, T Kerkau, T Hünig.
Ann Rheum Dis, 2005 Oct 22; 64 Suppl 4. PMID: 16239397    Free PMC article.
Review.
Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity.
Naoto Hirano, Marcus O Butler, +5 authors, Lee M Nadler.
Blood, 2005 Oct 22; 107(4). PMID: 16239433    Free PMC article.
Adoptive immunotherapy for cancer: building on success.
Luca Gattinoni, Daniel J Powell, Steven A Rosenberg, Nicholas P Restifo.
Nat Rev Immunol, 2006 Apr 20; 6(5). PMID: 16622476    Free PMC article.
Highly Cited. Review.
Checkpoint blockade in cancer immunotherapy.
Alan J Korman, Karl S Peggs, James P Allison.
Adv Immunol, 2006 May 30; 90. PMID: 16730267    Free PMC article.
Highly Cited. Review.
Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation.
Niklas Beyersdorf, Karen Balbach, Thomas Hünig, Thomas Kerkau.
Immunology, 2006 Aug 15; 119(4). PMID: 16903867    Free PMC article.
A variable immunoreceptor in a subpopulation of human neutrophils.
Kerstin Puellmann, Wolfgang E Kaminski, +4 authors, Alexander W Beham.
Proc Natl Acad Sci U S A, 2006 Sep 20; 103(39). PMID: 16983085    Free PMC article.
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
John J Zaunders, Susanna Ip, +15 authors, Anthony D Kelleher.
J Virol, 2006 Sep 29; 80(20). PMID: 17005693    Free PMC article.
CD80/CD28 co-stimulation in human brucellosis.
P Skendros, P Boura, F Kamaria, M Raptopoulou-Gigi.
Clin Exp Immunol, 2006 Nov 15; 146(3). PMID: 17100758    Free PMC article.
Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines.
Wai Kan Chiu, Monchou Fann, Nan-ping Weng.
J Immunol, 2006 Nov 23; 177(11). PMID: 17114451    Free PMC article.
Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway.
Yun-Gyoung Hur, Chang-Hee Suh, Sungjoo Kim, Jonghwa Won.
J Clin Immunol, 2006 Dec 30; 27(1). PMID: 17195044
Gene expression and generation of CD28-CD8 T cells mediated by interleukin 15.
Jason Godlove, Wai Kan Chiu, Nan-ping Weng.
Exp Gerontol, 2007 Jan 06; 42(5). PMID: 17204390    Free PMC article.
Review.
DC-HIL is a negative regulator of T lymphocyte activation.
Jin-Sung Chung, Kota Sato, +2 authors, Kiyoshi Ariizumi.
Blood, 2007 Feb 08; 109(10). PMID: 17284525    Free PMC article.
The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge.
Leandro J Carreño, Susan M Bueno, +2 authors, Alexis M Kalergis.
Immunology, 2007 Feb 23; 121(2). PMID: 17313485    Free PMC article.
A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.
Vincenzo Di Bartolo, Benjamin Montagne, +8 authors, Oreste Acuto.
J Exp Med, 2007 Mar 14; 204(3). PMID: 17353368    Free PMC article.
Granulocyte-macrophage colony-stimulating factor drives monocytes to CD14low CD83+ DCSIGN- interleukin-10-producing myeloid cells with differential effects on T-cell subsets.
Dipyaman Ganguly, Kausik Paul, +4 authors, Santu Bandyopadhyay.
Immunology, 2007 Apr 17; 121(4). PMID: 17433076    Free PMC article.
Pertussis toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T cells.
Olivia D Schneider, Alison A Weiss, William E Miller.
Infect Immun, 2007 Jun 15; 75(8). PMID: 17562776    Free PMC article.
The secretory IFN-gamma response of single CD4 memory cells after activation on different antigen presenting cell types.
Patrick A Ott, Magdalena Tary-Lehmann, Paul V Lehmann.
Clin Immunol, 2007 Jul 17; 124(3). PMID: 17632036    Free PMC article.
Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.
Xuguang Tai, Francois Van Laethem, Arlene H Sharpe, Alfred Singer.
Proc Natl Acad Sci U S A, 2007 Aug 19; 104(34). PMID: 17702861    Free PMC article.
Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.
Zoe Waibler, Linda Y Sender, +6 authors, Burkhart Schraven.
PLoS One, 2008 Mar 06; 3(3). PMID: 18320029    Free PMC article.
Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis.
Giuseppe Mazzarella, Rosita Stefanile, +9 authors, Carmen Gianfrani.
Gastroenterology, 2008 Apr 09; 134(4). PMID: 18395083    Free PMC article.
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.
Tadashi Yokosuka, Wakana Kobayashi, +5 authors, Takashi Saito.
Immunity, 2008 Oct 14; 29(4). PMID: 18848472    Free PMC article.
Highly Cited.
Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor.
Guo-Chung Dong, Ping-Hsien Chuang, +6 authors, Hueih Min Chen.
Pharm Res, 2008 Nov 08; 26(2). PMID: 18989760    Free PMC article.
T-cell co-stimulatory pathways in autoimmunity.
Jörg J Goronzy, Cornelia M Weyand.
Arthritis Res Ther, 2008 Nov 26; 10 Suppl 1. PMID: 19007423    Free PMC article.
Review.
Signals and sequences that control CD28 localization to the central region of the immunological synapse.
Mariano Sanchez-Lockhart, Beth Graf, Jim Miller.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017952    Free PMC article.
T cell activation.
Jennifer E Smith-Garvin, Gary A Koretzky, Martha S Jordan.
Annu Rev Immunol, 2009 Jan 10; 27. PMID: 19132916    Free PMC article.
Highly Cited. Review.
Two pathways of costimulation through CD28.
Jim Miller, Christina Baker, +6 authors, Takeshi Yoshida.
Immunol Res, 2009 Feb 14; 45(2-3). PMID: 19214786    Free PMC article.
Review.
Abatacept does not induce direct gene expression changes in antigen-presenting cells.
Julie A Carman, Patricia M Davis, +6 authors, Steven G Nadler.
J Clin Immunol, 2009 Mar 05; 29(4). PMID: 19259798
CD28 and CTLA-4 coreceptor expression and signal transduction.
Christopher E Rudd, Alison Taylor, Helga Schneider.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426212    Free PMC article.
Highly Cited. Review.
The significance of OX40 and OX40L to T-cell biology and immune disease.
Michael Croft, Takanori So, Wei Duan, Pejman Soroosh.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426222    Free PMC article.
Highly Cited. Review.
Sequence, structure, function, immunity: structural genomics of costimulation.
Kausik Chattopadhyay, Eszter Lazar-Molnar, +7 authors, Steven C Almo.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426233    Free PMC article.
Review.
NSOM/QD-based direct visualization of CD3-induced and CD28-enhanced nanospatial coclustering of TCR and coreceptor in nanodomains in T cell activation.
Liyun Zhong, Gucheng Zeng, +5 authors, Zheng W Chen.
PLoS One, 2009 Jun 19; 4(6). PMID: 19536289    Free PMC article.
Epigenetics of human T cells during the G0-->G1 transition.
Alexander E Smith, Constantinos Chronis, +6 authors, N Shaun B Thomas.
Genome Res, 2009 Jun 24; 19(8). PMID: 19546172    Free PMC article.
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells.
Niklas Engels, Lars Morten König, +5 authors, Jürgen Wienands.
Nat Immunol, 2009 Aug 12; 10(9). PMID: 19668218
Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.
Ana V Miletic, Daniel B Graham, +8 authors, Wojciech Swat.
PLoS One, 2009 Aug 13; 4(8). PMID: 19672294    Free PMC article.
Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.
Catarina Sacristán, Stefan A Schattgen, +3 authors, Yvonne Rosenstein.
Eur J Immunol, 2009 Aug 25; 39(9). PMID: 19701889    Free PMC article.
Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication.
Xiao-Song Zhong, Maiko Matsushita, +2 authors, Michel Sadelain.
Mol Ther, 2009 Sep 24; 18(2). PMID: 19773745    Free PMC article.
Highly Cited.
IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age span.
Huy Nguyen, Nan-ping Weng.
J Leukoc Biol, 2009 Oct 03; 87(1). PMID: 19797296    Free PMC article.
Organization of proximal signal initiation at the TCR:CD3 complex.
Clifford S Guy, Dario A A Vignali.
Immunol Rev, 2009 Nov 17; 232(1). PMID: 19909352    Free PMC article.
Review.
CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.
Victor Peperzak, Yanling Xiao, Elise A M Veraar, Jannie Borst.
J Clin Invest, 2009 Dec 04; 120(1). PMID: 19955658    Free PMC article.
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.
Elisa Bjørgo, Silje A Solheim, +6 authors, Kjetil Taskén.
Mol Cell Biol, 2010 Jan 21; 30(7). PMID: 20086095    Free PMC article.
Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase.
Hun Sik Kim, Asmita Das, +2 authors, Eric O Long.
Immunity, 2010 Mar 02; 32(2). PMID: 20189481    Free PMC article.
Induction/engineering, detection, selection, and expansion of clinical-grade human antigen-specific CD8 cytotoxic T cell clones for adoptive immunotherapy.
Matjaz Jeras, Irena Bricl, Robert Zorec, Urban Svajger.
J Biomed Biotechnol, 2010 Mar 13; 2010. PMID: 20224660    Free PMC article.
Review.
Cbl-b in T-cell activation.
Magdalena Paolino, Josef M Penninger.
Semin Immunopathol, 2010 May 12; 32(2). PMID: 20458601
Review.
Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten.
Peter T Jindra, Jessamyn Bagley, Jonathan G Godwin, John Iacomini.
J Immunol, 2010 Jun 16; 185(2). PMID: 20548023    Free PMC article.
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
Elizabeth D Thompson, Hilda L Enriquez, Yang-Xin Fu, Victor H Engelhard.
J Exp Med, 2010 Jul 28; 207(8). PMID: 20660615    Free PMC article.
NF-κB inducing kinase: a key regulator in the immune system and in cancer.
Yee Mon Thu, Ann Richmond.
Cytokine Growth Factor Rev, 2010 Aug 06; 21(4). PMID: 20685151    Free PMC article.
Review.
Plasmodium falciparum: differential merozoite dose requirements for maximal production of various inflammatory cytokines.
Xianzhu Wu, Nagaraj M Gowda, D Channe Gowda.
Exp Parasitol, 2010 Aug 07; 127(1). PMID: 20688058    Free PMC article.
CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis.
Maíra Felonato, Adriana Pina, +3 authors, Vera L G Calich.
Infect Immun, 2010 Aug 18; 78(11). PMID: 20713624    Free PMC article.
CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction.
P Nair, R Melarkode, D Rajkumar, E Montero.
Clin Exp Immunol, 2010 Aug 24; 162(1). PMID: 20726988    Free PMC article.
Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice.
Ingunn M Stromnes, Joseph N Blattman, +3 authors, Philip D Greenberg.
J Clin Invest, 2010 Oct 05; 120(10). PMID: 20890046    Free PMC article.
Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis.
Zili Zhang, Wenwei Zhong, +6 authors, James T Rosenbaum.
Am J Pathol, 2010 Oct 19; 177(6). PMID: 20952591    Free PMC article.
Effects of the plasmid-encoded toxin of enteroaggregative Escherichia coli on focal adhesion complexes.
Renato E Cappello, Guadalupe Estrada-Gutierrez, +3 authors, James P Nataro.
FEMS Immunol Med Microbiol, 2011 Jan 06; 61(3). PMID: 21205005    Free PMC article.
CD28 co-signaling in the adaptive immune response.
Pavel Riha, Christopher E Rudd.
Self Nonself, 2011 Apr 14; 1(3). PMID: 21487479    Free PMC article.
Searching for "signal 2": costimulation requirements of γδ T cells.
Julie C Ribot, Ana debarros, Bruno Silva-Santos.
Cell Mol Life Sci, 2011 May 05; 68(14). PMID: 21541698
Review.
Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells.
Shan He, Koji Kato, +6 authors, Yi Zhang.
PLoS One, 2011 May 26; 6(5). PMID: 21611151    Free PMC article.
Role of unusual CD4+ CD28- T cells in acute coronary syndrome.
Wenjie Sun, Lihui Zheng, Lijuan Huang.
Mol Biol Rep, 2011 Jun 23; 39(3). PMID: 21695428
Review.
Regulation of NF-κB induction by TCR/CD28.
Jing Cheng, Angela Montecalvo, Lawrence P Kane.
Immunol Res, 2011 Jul 01; 50(2-3). PMID: 21717079    Free PMC article.
Review.
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28.
Kok-Fai Kong, Tadashi Yokosuka, +3 authors, Amnon Altman.
Nat Immunol, 2011 Oct 04; 12(11). PMID: 21964608    Free PMC article.
Activation of cord blood myeloid dendritic cells by Trypanosoma cruzi and parasite-specific antibodies, proliferation of CD8+ T cells, and production of IFN-γ.
Patricia Rodriguez, Yves Carlier, Carine Truyens.
Med Microbiol Immunol, 2011 Nov 01; 201(2). PMID: 22037700
Targeting co-stimulatory pathways in gene therapy.
Xiaopei Huang, Yiping Yang.
Front Microbiol, 2011 Nov 03; 2. PMID: 22046171    Free PMC article.
Cutting edge: A role for inside-out signaling in TCR regulation of CD28 ligand binding.
Mariano Sanchez-Lockhart, Minsoo Kim, Jim Miller.
J Immunol, 2011 Nov 10; 187(11). PMID: 22068237    Free PMC article.
Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells.
Yu-Hui Huang, Dorothy K Sojka, Deborah J Fowell.
J Immunol, 2012 Jan 10; 188(3). PMID: 22227565    Free PMC article.
The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis.
Ricardo F Antunes, Juan Carlos Kaski, Ingrid E Dumitriu.
J Biomed Biotechnol, 2012 Jan 12; 2012. PMID: 22235167    Free PMC article.
Review.
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Peng Gu, Julia Fang Gao, +3 authors, Li Zhang.
Cell Mol Immunol, 2012 Feb 07; 9(2). PMID: 22307040    Free PMC article.
Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.
Stephen J Orr, Daniel R Boutz, +9 authors, N Shaun B Thomas.
Mol Syst Biol, 2012 Mar 15; 8. PMID: 22415777    Free PMC article.
Molecular mechanisms of treg-mediated T cell suppression.
Angelika Schmidt, Nina Oberle, Peter H Krammer.
Front Immunol, 2012 May 09; 3. PMID: 22566933    Free PMC article.
Highly Cited.
CD28 family and chronic rejection: "to belatacept...And beyond!".
Marcos V Silva, Juliana R Machado, +3 authors, Rosana R M Corrêa.
J Transplant, 2012 Jun 22; 2012. PMID: 22720132    Free PMC article.
NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells.
Blandine C Mercier, Erwan Ventre, +4 authors, Nathalie Bonnefoy.
PLoS One, 2012 Aug 01; 7(7). PMID: 22848741    Free PMC article.
PATHLOGIC-S: a scalable Boolean framework for modelling cellular signalling.
Liam G Fearnley, Lars K Nielsen.
PLoS One, 2012 Aug 11; 7(8). PMID: 22879903    Free PMC article.
CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells.
Tong Seng Lim, James Kang Hao Goh, +3 authors, Paola Ricciardi-Castagnoli.
PLoS One, 2012 Oct 02; 7(9). PMID: 23024807    Free PMC article.
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.
Yuning Lu, Helga Schneider, Christopher E Rudd.
Blood, 2012 Oct 11; 120(23). PMID: 23047820    Free PMC article.
Tumor vessel-injuring ability improves antitumor effect of cytotoxic T lymphocytes in adoptive immunotherapy.
N Kanagawa, T Yanagawa, +2 authors, S Nakagawa.
Cancer Gene Ther, 2012 Nov 24; 20(1). PMID: 23175243    Free PMC article.
Vaccines for pancreatic cancer.
Kevin C Soares, Lei Zheng, Barish Edil, Elizabeth M Jaffee.
Cancer J, 2012 Nov 29; 18(6). PMID: 23187853    Free PMC article.
Review.
Trial watch: Prognostic and predictive value of the immune infiltrate in cancer.
Laura Senovilla, Erika Vacchelli, +9 authors, Lorenzo Galluzzi.
Oncoimmunology, 2012 Dec 18; 1(8). PMID: 23243596    Free PMC article.
Highly Cited.
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.
Ivana Munitic, Mirela Kuka, +2 authors, Jonathan D Ashwell.
J Immunol, 2012 Dec 28; 190(3). PMID: 23269247    Free PMC article.
Signaling by the phosphoinositide 3-kinase family in immune cells.
Klaus Okkenhaug.
Annu Rev Immunol, 2013 Jan 22; 31. PMID: 23330955    Free PMC article.
Highly Cited. Review.
CTLA-4 blockade in tumor models: an overview of preclinical and translational research.
Joseph F Grosso, Maria N Jure-Kunkel.
Cancer Immun, 2013 Feb 08; 13. PMID: 23390376    Free PMC article.
Highly Cited. Review.
Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse.
Pablo A González, Leandro J Carreño, +3 authors, Alexis M Kalergis.
Clin Dev Immunol, 2013 Mar 28; 2013. PMID: 23533456    Free PMC article.
Review.
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.
Jonathan M Coquet, Julie C Ribot, +9 authors, Jannie Borst.
J Exp Med, 2013 Apr 03; 210(4). PMID: 23547099    Free PMC article.
γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation.
Renee M Laird, Benjamin J Wolf, Michael F Princiotta, Sandra M Hayes.
PLoS One, 2013 May 15; 8(5). PMID: 23671671    Free PMC article.
Flavonoid naringenin: a potential immunomodulator for Chlamydia trachomatis inflammation.
Abebayehu N Yilma, Shree R Singh, Lisa Morici, Vida A Dennis.
Mediators Inflamm, 2013 Jun 15; 2013. PMID: 23766556    Free PMC article.
Host and microbial factors in regulation of T cells in the intestine.
Chang H Kim.
Front Immunol, 2013 Jun 19; 4. PMID: 23772228    Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer.
Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer.
Front Immunol, 2013 Jun 27; 4. PMID: 23801991    Free PMC article.
Role of microglia in CNS autoimmunity.
Tobias Goldmann, Marco Prinz.
Clin Dev Immunol, 2013 Jul 11; 2013. PMID: 23840238    Free PMC article.
Review.
CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response.
Marc Martínez-Llordella, Jonathan H Esensten, +7 authors, Jeffrey A Bluestone.
J Exp Med, 2013 Jul 24; 210(8). PMID: 23878307    Free PMC article.
Soluble CD80 restores T cell activation and overcomes tumor cell programmed death ligand 1-mediated immune suppression.
Samuel T Haile, Sonia P Dalal, +2 authors, Suzanne Ostrand-Rosenberg.
J Immunol, 2013 Aug 07; 191(5). PMID: 23918985    Free PMC article.
Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells.
Christian Peters, Hans-Heinrich Oberg, Dieter Kabelitz, Daniela Wesch.
Cell Mol Life Sci, 2013 Oct 05; 71(10). PMID: 24091816    Free PMC article.
Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays.
Jovana Matic, Janosch Deeg, +2 authors, Joachim P Spatz.
Nano Lett, 2013 Oct 12; 13(11). PMID: 24111628    Free PMC article.
Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration.
Yvonne Samstag, Isabel John, Guido H Wabnitz.
Immunol Rev, 2013 Oct 15; 256(1). PMID: 24117811    Free PMC article.
Review.
Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse.
Audrey Le Floc'h, Yoshihiko Tanaka, +4 authors, Morgan Huse.
J Exp Med, 2013 Nov 06; 210(12). PMID: 24190432    Free PMC article.
Neisseria gonorrhoeae induces a tolerogenic phenotype in macrophages to modulate host immunity.
Alejandro Escobar, Enzo Candia, +8 authors, Mónica Imarai.
Mediators Inflamm, 2013 Nov 10; 2013. PMID: 24204097    Free PMC article.
A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.
J Joris Witsenburg, Heike Glauner, +5 authors, Roland Brock.
PLoS One, 2013 Nov 10; 8(10). PMID: 24205378    Free PMC article.
Exploiting apoptosis for therapeutic tolerance induction.
Daniel R Getts, Derrick P McCarthy, Stephen D Miller.
J Immunol, 2013 Nov 19; 191(11). PMID: 24244028    Free PMC article.
Review.
Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly.
Aurélie Le Page, Carl Fortin, +6 authors, Tamas Fülöp.
Cell Commun Signal, 2014 Jan 11; 12. PMID: 24405902    Free PMC article.
T cell ageing: effects of age on development, survival & function.
Nasir Salam, Sanket Rane, +11 authors, Vineeta Bal.
Indian J Med Res, 2014 Jan 18; 138(5). PMID: 24434315    Free PMC article.
Review.
Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer.
Takeshi Ishikawa, Satoshi Kokura, +16 authors, Toshikazu Yoshikawa.
PLoS One, 2014 Feb 06; 9(1). PMID: 24497917    Free PMC article.
Vaccine therapy for pancreatic cancer.
Bulent Salman, Donger Zhou, +2 authors, Lei Zheng.
Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498551    Free PMC article.
Review.
Immunosuppressive effects of erythropoietin on human alloreactive T cells.
Paolo Cravedi, Joaquin Manrique, +5 authors, Peter S Heeger.
J Am Soc Nephrol, 2014 Mar 29; 25(9). PMID: 24676641    Free PMC article.
Mechanistic considerations for the use of monoclonal antibodies for cancer therapy.
Patrick M Glassman, Joseph P Balthasar.
Cancer Biol Med, 2014 Apr 17; 11(1). PMID: 24738036    Free PMC article.
Review.
Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.
Chen Liu, Hong-Cheng Wang, +6 authors, Yu Zhang.
J Immunol, 2014 Jun 13; 193(2). PMID: 24920844    Free PMC article.
CD4 T-cell memory generation and maintenance.
David J Gasper, Melba Marie Tejera, M Suresh.
Crit Rev Immunol, 2014 Jun 19; 34(2). PMID: 24940912    Free PMC article.
Review.
Clinical outcome in patients with acute coronary syndrome and outward remodeling is associated with a predominant inflammatory response.
Alejandra Madrid-Miller, Luis Chávez-Sánchez, +7 authors, Francisco Blanco-Favela.
BMC Res Notes, 2014 Sep 26; 7. PMID: 25253465    Free PMC article.
B7-H4 expression in bladder urothelial carcinoma and immune escape mechanisms.
Wei-Hui Liu, Ya-Yu Chen, +5 authors, Jia-Liang Wang.
Oncol Lett, 2014 Nov 05; 8(6). PMID: 25364421    Free PMC article.
In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.
Stéphanie O Morin, Valentin Giroux, +7 authors, Jacques A Nunès.
Cell Mol Life Sci, 2015 Mar 03; 72(14). PMID: 25725801    Free PMC article.
The importance of co-stimulation in the orchestration of T helper cell differentiation.
Jonathan M Coquet, Lisa Rausch, Jannie Borst.
Immunol Cell Biol, 2015 Mar 25; 93(9). PMID: 25801480
Review.
Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.
Ruijun Tian, Haopeng Wang, +10 authors, Tony Pawson.
Proc Natl Acad Sci U S A, 2015 Apr 02; 112(13). PMID: 25829543    Free PMC article.
Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm.
S Vessillier, D Eastwood, +6 authors, R Stebbings.
J Immunol Methods, 2015 May 12; 424. PMID: 25960173    Free PMC article.
Neisseria gonorrhoeae Modulates Immunity by Polarizing Human Macrophages to a M2 Profile.
María Carolina Ortiz, Claudia Lefimil, +5 authors, Alejandro Escobar.
PLoS One, 2015 Jul 01; 10(6). PMID: 26125939    Free PMC article.
The pharmacology of second-generation chimeric antigen receptors.
Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain.
Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802    Free PMC article.
Highly Cited. Review.
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment.
Claire Vanpouille-Box, Karsten A Pilones, +2 authors, Sandra Demaria.
Vaccine, 2015 Jul 08; 33(51). PMID: 26148880    Free PMC article.
Review.
The life (and death) of CD4+ CD28(null) T cells in inflammatory diseases.
Ingrid E Dumitriu.
Immunology, 2015 Jul 21; 146(2). PMID: 26190355    Free PMC article.
Review.
Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients.
Sara J Felts, Virginia P Van Keulen, +9 authors, Larry R Pease.
Cancer Immunol Immunother, 2015 Aug 08; 64(11). PMID: 26245876    Free PMC article.
Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2.
Alexander Ungewickell, Aparna Bhaduri, +14 authors, Paul A Khavari.
Nat Genet, 2015 Aug 11; 47(9). PMID: 26258847    Free PMC article.
Highly Cited.
The multifaceted role of PIP2 in leukocyte biology.
Loretta Tuosto, Cristina Capuano, +2 authors, Ricciarda Galandrini.
Cell Mol Life Sci, 2015 Aug 13; 72(23). PMID: 26265181
Review.
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.
David H Gardner, Louisa E Jeffery, +4 authors, David M Sansom.
J Immunol, 2015 Aug 16; 195(6). PMID: 26276872    Free PMC article.
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.
Yun Xiao, Guilin Qiao, +6 authors, Jian Zhang.
J Immunol, 2015 Sep 30; 195(9). PMID: 26416283    Free PMC article.
Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand.
Hong-Sheng Lim, Shaun-Paul Cordoba, +4 authors, P Anton van der Merwe.
J Immunol, 2015 Oct 27; 195(11). PMID: 26500347    Free PMC article.
Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction.
Masahiro Tanemura, Eiji Miyoshi, +7 authors, Yuichiro Doki.
World J Gastroenterol, 2015 Nov 03; 21(40). PMID: 26523105    Free PMC article.
Review.
MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway.
Wei Sang, Ying Wang, +11 authors, Kailin Xu.
Immunol Lett, 2015 Nov 10; 172. PMID: 26549736    Free PMC article.
Aging, cytomegalovirus (CMV) and influenza vaccine responses.
Daniela Frasca, Bonnie B Blomberg.
Hum Vaccin Immunother, 2015 Nov 21; 12(3). PMID: 26588038    Free PMC article.
Review.
CD28-mediated T cell response is upregulated by exogenous application of autologous Hsp70-peptide complex in a tumor-bearing host.
Sanjay Kumar, Pramod Kumar Gautam, Munendra Singh Tomar, Arbind Acharya.
Immunol Res, 2015 Dec 08; 64(1). PMID: 26639355
Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus.
Nils Rother, Johan van der Vlag.
Front Immunol, 2015 Dec 10; 6. PMID: 26648939    Free PMC article.
Review.
Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells.
Jonathan P H Fisher, Barry Flutter, +4 authors, John Anderson.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942051    Free PMC article.
MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells.
Mario Martínez Soldevilla, Helena Villanueva, +5 authors, Fernando Pastor.
Oncotarget, 2016 Mar 19; 7(17). PMID: 26992239    Free PMC article.
Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies.
Alistair M Cook, Alison M McDonnell, Richard A Lake, Anna K Nowak.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141331    Free PMC article.
CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo.
Gengwen Tian, Amy N Courtney, +10 authors, Leonid S Metelitsa.
J Clin Invest, 2016 May 18; 126(6). PMID: 27183388    Free PMC article.
Highly Cited.
TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.
Julia Svedova, Naomi Tsurutani, +2 authors, Anthony T Vella.
J Immunol, 2016 May 18; 196(11). PMID: 27183621    Free PMC article.
CD28 Costimulation: From Mechanism to Therapy.
Jonathan H Esensten, Ynes A Helou, +2 authors, Jeffrey A Bluestone.
Immunity, 2016 May 19; 44(5). PMID: 27192564    Free PMC article.
Highly Cited. Review.
Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation.
Nicla Porciello, Martina Kunkl, Antonella Viola, Loretta Tuosto.
Front Immunol, 2016 Jun 01; 7. PMID: 27242793    Free PMC article.
Review.
Immunoregulatory pathways following strong inflammatory processes markedly impair CD4+ T cell responses.
Christine M Minnar, William J Murphy.
Hum Vaccin Immunother, 2016 Jul 14; 12(9). PMID: 27409155    Free PMC article.
Review.
Flt3 Ligand Treatment Attenuates T Cell Dysfunction and Improves Survival in a Murine Model of Burn Wound Sepsis.
Naeem K Patil, Julia K Bohannon, +5 authors, Edward R Sherwood.
Shock, 2016 Jul 28; 47(1). PMID: 27454384    Free PMC article.
Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
Jessica Dobbins, Etienne Gagnon, +4 authors, Kai W Wucherpfennig.
Sci Signal, 2016 Jul 28; 9(438). PMID: 27460989    Free PMC article.
Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.
Ornella Franzese, Belinda Palermo, +6 authors, Paola Nisticò.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467927    Free PMC article.
Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression.
Naeem K Patil, Julia K Bohannon, Edward R Sherwood.
Pharmacol Res, 2016 Jul 30; 111. PMID: 27468649    Free PMC article.
Review.
NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes.
Galaxia M Rodriguez, Diwakar Bobbala, +8 authors, Subburaj Ilangumaran.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471621    Free PMC article.
Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.
Yi Wang, Cindy S Ma, +33 authors, Jean-Laurent Casanova.
J Exp Med, 2016 Nov 05; 213(11). PMID: 27647349    Free PMC article.
[Progress in Immunotherapy for Squamous Non-small Cell Lung Cancer].
Shouzheng Wang, Junling Li.
Zhongguo Fei Ai Za Zhi, 2016 Oct 21; 19(10). PMID: 27760599    Free PMC article.
Review.
Unraveling the Role of Allo-Antibodies and Transplant Injury.
Yoshiko Matsuda, Minnie M Sarwal.
Front Immunol, 2016 Nov 08; 7. PMID: 27818660    Free PMC article.
Review.
Ipilimumab: from preclinical development to future clinical perspectives in melanoma.
Paul Letendre, Varun Monga, Mohammed Milhem, Yousef Zakharia.
Future Oncol, 2016 Nov 25; 13(7). PMID: 27882779    Free PMC article.
Review.
T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca2+ Influx.
Kristin Schmiedeberg, Hardy Krause, +3 authors, Monika C Brunner-Weinzierl.
PLoS One, 2016 Nov 29; 11(11). PMID: 27893767    Free PMC article.
Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders.
Ga Hye Lee, Won-Woo Lee.
Immune Netw, 2016 Dec 31; 16(6). PMID: 28035207    Free PMC article.
Review.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.
Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri.
Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974    Free PMC article.
Review.
CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond.
ZeNan L Chang, Yvonne Y Chen.
Trends Mol Med, 2017 Apr 19; 23(5). PMID: 28416139    Free PMC article.
Review.
Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins.
Jolanda H M van Bilsen, Edyta Sienkiewicz-Szłapka, +15 authors, Erwin L Roggen.
Clin Transl Allergy, 2017 May 17; 7. PMID: 28507730    Free PMC article.
Review.
Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters.
Alison M McDonnell, Alistair Cook, +2 authors, Anna K Nowak.
BMC Cancer, 2017 Jun 18; 17(1). PMID: 28619093    Free PMC article.
Engineering CAR-T cells.
Cheng Zhang, Jun Liu, Jiang F Zhong, Xi Zhang.
Biomark Res, 2017 Jun 28; 5. PMID: 28652918    Free PMC article.
Highly Cited. Review.
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.
Gabriela Andrejeva, Jeffrey C Rathmell.
Cell Metab, 2017 Jul 07; 26(1). PMID: 28683294    Free PMC article.
Highly Cited.
Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.
Masashi Watanabe, Chiharu Fujihara, +4 authors, Richard J Hodes.
J Exp Med, 2017 Aug 05; 214(9). PMID: 28768709    Free PMC article.
Increased Neutralizing Antibody Production and Interferon-γ Secretion in Response to Porcine Reproductive and Respiratory Syndrome Virus Immunization in Genetically Modified Pigs.
Guangping Huang, Xianyong Liu, +6 authors, Xun Suo.
Front Immunol, 2017 Sep 29; 8. PMID: 28955336    Free PMC article.
Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan.
Ahmad F Karim, Obondo J Sande, +8 authors, W Henry Boom.
Proteomics, 2017 Oct 11; 17(22). PMID: 28994205    Free PMC article.
Aptamer-Based Therapeutic Approaches to Target Cancer Stem Cells.
Gang Zhou, Olivier Latchoumanin, +5 authors, Liang Qiao.
Theranostics, 2017 Nov 08; 7(16). PMID: 29109790    Free PMC article.
Review.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
Review.
Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation.
Sara Zumerle, Barbara Molon, Antonella Viola.
Front Immunol, 2017 Nov 23; 8. PMID: 29163534    Free PMC article.
Review.
Introducing Membrane Charge and Membrane Potential to T Cell Signaling.
Yuanqing Ma, Kate Poole, Jesse Goyette, Katharina Gaus.
Front Immunol, 2017 Nov 25; 8. PMID: 29170669    Free PMC article.
Review.
Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation.
Nicholas Jones, James G Cronin, +7 authors, Nigel J Francis.
Front Immunol, 2017 Nov 25; 8. PMID: 29170670    Free PMC article.
A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells.
Talal A Chatila, Raffaele De Palma.
Eur J Immunol, 2017 Dec 07; 47(12). PMID: 29211935    Free PMC article.
Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.
Mohamed Mahgoub, Jun-Ichirou Yasunaga, +4 authors, Masao Matsuoka.
Proc Natl Acad Sci U S A, 2018 Jan 24; 115(6). PMID: 29358408    Free PMC article.
Highly Cited.
Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists.
Christopher T Petersen, Mojibade Hassan, +9 authors, Edmund K Waller.
Blood Adv, 2018 Feb 02; 2(3). PMID: 29386194    Free PMC article.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.
Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson.
PLoS One, 2018 Apr 05; 13(4). PMID: 29617360    Free PMC article.
Posttranscriptional regulation of T helper cell fate decisions.
Kai P Hoefig, Vigo Heissmeyer.
J Cell Biol, 2018 Apr 25; 217(8). PMID: 29685903    Free PMC article.
Review.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
Review.
Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens.
Jeremy D Waight, Dhan Chand, +14 authors, Nicholas S Wilson.
Cancer Cell, 2018 Jun 13; 33(6). PMID: 29894690    Free PMC article.
CD28 between tolerance and autoimmunity: the side effects of animal models.
Nicla Porciello, Martina Kunkl, Loretta Tuosto.
F1000Res, 2018 Jun 16; 7. PMID: 29904580    Free PMC article.
Review.
CD4+CD28null T Lymphocytes are Associated with the Development of Atrial Fibrillation after Elective Cardiac Surgery.
Patrick Sulzgruber, Barbara Thaler, +11 authors, Alexander Niessner.
Sci Rep, 2018 Jun 27; 8(1). PMID: 29941960    Free PMC article.
Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.
Anisur Rahman, Abhinav Tiwari, Jatin Narula, Timothy Hickling.
CPT Pharmacometrics Syst Pharmacol, 2018 Sep 11; 7(10). PMID: 30198637    Free PMC article.
Review.
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency.
Immacolata Brigida, Matteo Zoccolillo, +43 authors, Alessandro Aiuti.
Blood, 2018 Sep 27; 132(22). PMID: 30254128    Free PMC article.
Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS Prodigy system.
Wei Zhang, Kimberly R Jordan, Brian Schulte, Enkhtsetseg Purev.
Drug Des Devel Ther, 2018 Oct 17; 12. PMID: 30323566    Free PMC article.
Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses.
Emad I Wafa, Sean M Geary, +3 authors, Aliasger K Salem.
J Pharmacol Exp Ther, 2018 Oct 27; 370(3). PMID: 30361239    Free PMC article.
Altered Cd8+ T lymphocyte Response Triggered by Arginase 1: Implication for Fatigue Intensification during Localized Radiation Therapy in Prostate Cancer Patients.
Leorey N Saligan, Nada Lukkahatai, +2 authors, Xiao-Min Wang.
Neuropsychiatry (London), 2018 Oct 27; 8(4). PMID: 30364895    Free PMC article.
Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory.
Sophie Viaud, Jennifer S Y Ma, +10 authors, Travis S Young.
Proc Natl Acad Sci U S A, 2018 Oct 31; 115(46). PMID: 30373813    Free PMC article.
Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients.
Belinda Palermo, Ornella Franzese, +9 authors, Paola Nisticò.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524882    Free PMC article.
Pentaerythritol-based lipid A bolsters the antitumor efficacy of a polyanhydride particle-based cancer vaccine.
Emad I Wafa, Sean M Geary, +3 authors, Aliasger K Salem.
Nanomedicine, 2019 Jul 19; 21. PMID: 31319179    Free PMC article.
Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis.
Qian Li, Yan Yan, +8 authors, Mengji Lu.
Front Immunol, 2019 Oct 02; 10. PMID: 31572396    Free PMC article.
Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer.
Peter Wierstra, Gerwin Sandker, +5 authors, Sandra Heskamp.
EJNMMI Radiopharm Chem, 2019 Nov 07; 4(1). PMID: 31696402    Free PMC article.
Review.
The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma.
Peng Liao, Haofan Wang, +2 authors, Xin-Hua Liang.
Front Immunol, 2019 Nov 12; 10. PMID: 31708918    Free PMC article.
Review.
Deoxynivalenol Affects Proliferation and Expression of Activation-Related Molecules in Major Porcine T-Cell Subsets.
Eleni Vatzia, Alix Pierron, +2 authors, Wilhelm Gerner.
Toxins (Basel), 2019 Nov 07; 11(11). PMID: 31694331    Free PMC article.
Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C.
Samuel D Shin, Alexandra Shin, +5 authors, Salvador Soriano.
J Neuroinflammation, 2019 Dec 19; 16(1). PMID: 31847862    Free PMC article.
The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy.
Jessica Michie, Conor J Kearney, +2 authors, Jane Oliaro.
Cells, 2020 Jan 18; 9(1). PMID: 31947615    Free PMC article.
Review.
Relationship of Peripheral Lymphocyte Subsets and Skeletal Muscle Mass Index in Sarcopenia: A Cross-Sectional Study.
S-W Huang, T Xu, C-T Zhang, H-L Zhou.
J Nutr Health Aging, 2020 Mar 03; 24(3). PMID: 32115615
Teaching an old dog new tricks: next-generation CAR T cells.
Nicholas Tokarew, Justyna Ogonek, +2 authors, Sebastian Kobold.
Br J Cancer, 2018 Nov 11; 120(1). PMID: 30413825    Free PMC article.
Highly Cited. Review.
Cheating the Hunger Games; Mechanisms Controlling Clonal Diversity of CD8 Effector and Memory Populations.
Inga Kavazović, Bojan Polić, Felix M Wensveen.
Front Immunol, 2018 Dec 18; 9. PMID: 30555492    Free PMC article.
Review.
TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells.
Fan Xia, Cheng-Rui Qian, +10 authors, Hai-Tao He.
Front Immunol, 2018 Dec 20; 9. PMID: 30564247    Free PMC article.
Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor.
Rongxue Wan, Jenny Wu, +11 authors, Shaoying Lu.
Sci Adv, 2019 Jun 22; 5(6). PMID: 31223643    Free PMC article.
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
Matthew F Pech, Linda E Fong, +7 authors, Jeffrey Settleman.
Elife, 2019 Aug 28; 8. PMID: 31452512    Free PMC article.
Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy.
Jinyu Zhang, Pablo Saenz-Lopez Larrocha, +3 authors, Jennifer D Wu.
J Immunother Cancer, 2019 Aug 27; 7(1). PMID: 31446896    Free PMC article.
Anaphylaxis-induced atrial fibrillation and anesthesia: Pathophysiologic and therapeutic considerations.
Nicholas G Kounis, Ioanna Koniari, +3 authors, George Hahalis.
Ann Card Anaesth, 2020 Jan 14; 23(1). PMID: 31929239    Free PMC article.
Review.
Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity.
Kuan Rong Chan, Xiaohui Wang, +14 authors, Eng Eong Ooi.
Nat Microbiol, 2016 Sep 20; 1. PMID: 27642668    Free PMC article.
Regulation of immune responses by E3 ubiquitin ligase Cbl-b.
Rong Tang, Wallace Y Langdon, Jian Zhang.
Cell Immunol, 2018 Nov 18; 340. PMID: 30442330    Free PMC article.
Review.
Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma.
Chune Yu, Xiaowei Liu, +4 authors, Hubing Shi.
Front Immunol, 2019 May 28; 10. PMID: 31134073    Free PMC article.
Review.
Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives.
Stefania Raimondo, Marzia Pucci, Riccardo Alessandro, Simona Fontana.
Int J Mol Sci, 2020 Apr 01; 21(7). PMID: 32225076    Free PMC article.
Review.
ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation.
Jennifer A Rohrs, Elizabeth L Siegler, Pin Wang, Stacey D Finley.
iScience, 2020 Apr 24; 23(4). PMID: 32325413    Free PMC article.
CD28 null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection.
Aalia Bano, Alejandra Pera, +4 authors, Florian Kern.
F1000Res, 2019 Apr 16; 8. PMID: 30984377    Free PMC article.
Review.
Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells.
Rowa Y Alhabbab.
Front Genet, 2020 May 12; 11. PMID: 32391048    Free PMC article.
Review.
T cell immunotherapy enhanced by designer biomaterials.
Zachary S Dunn, John Mac, Pin Wang.
Biomaterials, 2019 Jul 05; 217. PMID: 31271861    Free PMC article.
Review.
CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells.
Ankita Mitra, Sudarvili Shanthalingam, +10 authors, Barbara A Osborne.
Front Immunol, 2020 May 28; 11. PMID: 32457739    Free PMC article.
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer.
Laura Garcia Perez, Jan Kempski, +21 authors, Samuel Huber.
Nat Commun, 2020 May 27; 11(1). PMID: 32451418    Free PMC article.
Recent Advances: The Imbalance of Immune Cells and Cytokines in the Pathogenesis of Hepatocellular Carcinoma.
Kumar Jayant, Nagy Habib, +2 authors, Ramesh Arasaradnam.
Diagnostics (Basel), 2020 May 30; 10(5). PMID: 32466214    Free PMC article.
Review.
CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.
Gaëtan Blaize, Hélène Daniels-Treffandier, +13 authors, Renaud Lesourne.
Proc Natl Acad Sci U S A, 2020 May 22; 117(23). PMID: 32434911    Free PMC article.
Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions.
Xianhui Meng, Ruirui Jing, +2 authors, Jie Sun.
Front Immunol, 2020 Jul 09; 11. PMID: 32636832    Free PMC article.
Review.
The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation.
Jian Wu, Lu Xia, +17 authors, Xin-Zhuan Su.
Proc Natl Acad Sci U S A, 2020 Jul 02; 117(28). PMID: 32606244    Free PMC article.
Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors.
Alexandre Perrier, Audrey Didelot, +2 authors, Simon Garinet.
Biomolecules, 2020 Jul 28; 10(7). PMID: 32708698    Free PMC article.
Review.
Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders.
Bernard Vanhove, Nicolas Poirier, +9 authors, Gilles Blancho.
Antibodies (Basel), 2017 Nov 21; 6(4). PMID: 31548534    Free PMC article.
Review.
Helpless Priming Sends CD8+ T Cells on the Road to Exhaustion.
Julia Busselaar, Sun Tian, Hans van Eenennaam, Jannie Borst.
Front Immunol, 2020 Oct 31; 11. PMID: 33123174    Free PMC article.
Regulation of SATB1 during thymocyte development by TCR signaling.
Kamalvishnu P Gottimukkala, Rahul Jangid, +4 authors, Sanjeev Galande.
Mol Immunol, 2016 Jul 28; 77. PMID: 27454343    Free PMC article.
The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease.
Cornelia M Weyand, Gerald J Berry, Jörg J Goronzy.
J Leukoc Biol, 2017 Aug 30; 103(3). PMID: 28848042    Free PMC article.
Review.
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Judith Feucht, Jie Sun, +7 authors, Michel Sadelain.
Nat Med, 2018 Dec 19; 25(1). PMID: 30559421    Free PMC article.
Highly Cited.
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Masashi Watanabe, Ying Lu, Michael Breen, Richard J Hodes.
Nat Commun, 2020 Dec 10; 11(1). PMID: 33293517    Free PMC article.
'Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity.
Sanne C Lith, Bram W van Os, Tom T P Seijkens, Carlie J M de Vries.
Eur J Immunol, 2020 Oct 17; 50(11). PMID: 33063848    Free PMC article.
Review.
Targeting ubiquitin signaling for cancer immunotherapy.
Xiaofei Zhou, Shao-Cong Sun.
Signal Transduct Target Ther, 2021 Jan 14; 6(1). PMID: 33436547    Free PMC article.
Review.
CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors.
Huanpeng Chen, Fengjiao Wei, +4 authors, Zhaofeng Huang.
Cancer Immunol Immunother, 2021 Jan 14; 70(7). PMID: 33439295
The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies.
Lijuan Zhao, Qi Wang, +2 authors, Honglin Zhu.
Aging Dis, 2021 Feb 04; 12(1). PMID: 33532139    Free PMC article.
Review.
Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation.
Sander de Kivit, Mark Mensink, +7 authors, Jannie Borst.
Nat Metab, 2020 Sep 23; 2(10). PMID: 32958937
ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis.
Timoteo Marchini, Sophie Hansen, Dennis Wolf.
Cells, 2021 Mar 07; 10(2). PMID: 33669769    Free PMC article.
Review.
Innate immune receptor clustering and its role in immune regulation.
Miao Li, Yan Yu.
J Cell Sci, 2021 Feb 19; 134(4). PMID: 33597156    Free PMC article.
Review.
The Role of O-GlcNAcylation in Immune Cell Activation.
Amy Qiang, Chad Slawson, Patrick E Fields.
Front Endocrinol (Lausanne), 2021 May 15; 12. PMID: 33986724    Free PMC article.
Review.
Insulin Signaling in Arthritis.
Cesare Tripolino, Jacopo Ciaffi, +6 authors, Francesco Ursini.
Front Immunol, 2021 May 18; 12. PMID: 33995414    Free PMC article.
Review.
CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells.
Yo-Ping Lai, Lu-Cheng Kuo, +13 authors, Shu-Ching Chen.
Commun Biol, 2021 May 21; 4(1). PMID: 34011962    Free PMC article.
Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena.
Luis González-Osuna, Alfredo Sierra-Cristancho, +4 authors, Rolando Vernal.
Aging Dis, 2021 Aug 04; 12(5). PMID: 34341698    Free PMC article.
Characterization of local and peripheral immune system in pregnant and nonpregnant ewes.
Laurel D Quirke, Paul H Maclean, +3 authors, Jennifer L Juengel.
J Anim Sci, 2021 Jul 10; 99(8). PMID: 34240172    Free PMC article.
IgG Immune Complexes Inhibit Naïve T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells.
Wissam Charab, Matthew G Rosenberger, +8 authors, George Georgiou.
Front Immunol, 2021 Aug 28; 12. PMID: 34447380    Free PMC article.
Onchocerciasis Fingerprints in the Geriatric Population: Does Host Immunity Play a Role?
Cabirou Mounchili Shintouo, Robert Adamu Shey, +4 authors, Rose Njemini.
Trop Med Infect Dis, 2021 Aug 28; 6(3). PMID: 34449738    Free PMC article.
Review.
Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules.
Martina Kunkl, Carola Amormino, +6 authors, Loretta Tuosto.
Front Immunol, 2021 Sep 08; 12. PMID: 34489975    Free PMC article.
Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy.
Shubhangi Gavali, Jianing Liu, Xinyi Li, Magdalena Paolino.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639141    Free PMC article.
Review.
Virus in the pathogenesis of inflammatory bowel disease: role of Toll-like receptor 7/8/3.
Hamid Asadzadeh Aghdaei, Negar Jamshidi, +3 authors, Mohammad Reza Zali.
Gastroenterol Hepatol Bed Bench, 2021 Oct 19; 14(4). PMID: 34659656    Free PMC article.
Review.
Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients.
Mia J Coleman, Kourtney M Zimmerly, Xuexian O Yang.
Biomolecules, 2021 Oct 24; 11(10). PMID: 34680058    Free PMC article.
Review.
A T-Cell Epitope-Based Multi-Epitope Vaccine Designed Using Human HLA Specific T Cell Epitopes Induces a Near-Sterile Immunity against Experimental Visceral Leishmaniasis in Hamsters.
Aryandra Arya, Sunil K Arora.
Vaccines (Basel), 2021 Oct 27; 9(10). PMID: 34696166    Free PMC article.
Bacterial lectin BambL acts as a B cell superantigen.
Marco Frensch, Christina Jäger, +9 authors, Winfried Römer.
Cell Mol Life Sci, 2021 Nov 04; 78(24). PMID: 34731252    Free PMC article.
Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy.
Luis Felipe Olguín-Contreras, Anna N Mendler, +2 authors, Elfriede Noessner.
Front Immunol, 2021 Dec 17; 12. PMID: 34912334    Free PMC article.
Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier.
Somayeh Vafaei, Angelina O Zekiy, +4 authors, Majid Zamani.
Cancer Cell Int, 2022 Jan 05; 22(1). PMID: 34980128    Free PMC article.
Review.
Imaging Membrane Order and Dynamic Interactions in Living Cells with a DNA Zipper Probe.
Yousef Bagheri, Ahsan Ausaf Ali, +3 authors, Mingxu You.
Angew Chem Int Ed Engl, 2021 Nov 13; 61(6). PMID: 34767659    Free PMC article.
Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors.
Yosuke Dotsu, Daisuk Muraoka, +7 authors, Hiroaki Ikeda.
J Immunother Cancer, 2022 Feb 05; 10(2). PMID: 35115364    Free PMC article.
DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms.
Anjun Jiao, Chenming Sun, +11 authors, Baojun Zhang.
Sci Adv, 2022 Feb 10; 8(6). PMID: 35138904    Free PMC article.
Senescent CD4+CD28- T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis.
Luis González-Osuna, Alfredo Sierra-Cristancho, +5 authors, Rolando Vernal.
Int J Mol Sci, 2022 Mar 11; 23(5). PMID: 35269683    Free PMC article.
Review.
Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons.
Adel Naimi, Rebar N Mohammed, +11 authors, Ehsan Razeghian.
Cell Commun Signal, 2022 Apr 09; 20(1). PMID: 35392976    Free PMC article.
Review.
c-Met-targeted chimeric antigen receptor T cells inhibit hepatocellular carcinoma cells in vitro and in vivo.
Xiaochen Huang, Jiaojiao Guo, +5 authors, Zhenqing Feng.
J Biomed Res, 2022 Apr 12; 36(1). PMID: 35403606    Free PMC article.
Agents of cancer immunosurveillance: HSPs and dsDNA.
Devanshi A Nayak, Robert J Binder.
Trends Immunol, 2022 Apr 07; 43(5). PMID: 35382994    Free PMC article.
Review.
CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.
Chao Yang, Mahesh Bachu, +6 authors, Lionel B Ivashkiv.
Nat Commun, 2022 Jun 15; 13(1). PMID: 35701499