. 2003 Dec; 3(12):939-51.
doi: 10.1038/nri1248.

CD28-mediated co-stimulation: a quantitative support for TCR signalling

Oreste Acuto 1 Frédérique Michel  
  • PMID: 14647476
  •     246 citations

No abstract available

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In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.
Stéphanie O Morin, Valentin Giroux, +7 authors, Jacques A Nunès.
Cell Mol Life Sci, 2015 Mar 03; 72(14). PMID: 25725801    Free PMC article.
The importance of co-stimulation in the orchestration of T helper cell differentiation.
Jonathan M Coquet, Lisa Rausch, Jannie Borst.
Immunol Cell Biol, 2015 Mar 25; 93(9). PMID: 25801480
Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.
Ruijun Tian, Haopeng Wang, +10 authors, Tony Pawson.
Proc Natl Acad Sci U S A, 2015 Apr 02; 112(13). PMID: 25829543    Free PMC article.
Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm.
S Vessillier, D Eastwood, +6 authors, R Stebbings.
J Immunol Methods, 2015 May 12; 424. PMID: 25960173    Free PMC article.
Neisseria gonorrhoeae Modulates Immunity by Polarizing Human Macrophages to a M2 Profile.
María Carolina Ortiz, Claudia Lefimil, +5 authors, Alejandro Escobar.
PLoS One, 2015 Jul 01; 10(6). PMID: 26125939    Free PMC article.
The pharmacology of second-generation chimeric antigen receptors.
Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain.
Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802    Free PMC article.
Highly Cited. Review.
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment.
Claire Vanpouille-Box, Karsten A Pilones, +2 authors, Sandra Demaria.
Vaccine, 2015 Jul 08; 33(51). PMID: 26148880    Free PMC article.
The life (and death) of CD4+ CD28(null) T cells in inflammatory diseases.
Ingrid E Dumitriu.
Immunology, 2015 Jul 21; 146(2). PMID: 26190355    Free PMC article.
Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients.
Sara J Felts, Virginia P Van Keulen, +9 authors, Larry R Pease.
Cancer Immunol Immunother, 2015 Aug 08; 64(11). PMID: 26245876    Free PMC article.
Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2.
Alexander Ungewickell, Aparna Bhaduri, +14 authors, Paul A Khavari.
Nat Genet, 2015 Aug 11; 47(9). PMID: 26258847    Free PMC article.
Highly Cited.
The multifaceted role of PIP2 in leukocyte biology.
Loretta Tuosto, Cristina Capuano, +2 authors, Ricciarda Galandrini.
Cell Mol Life Sci, 2015 Aug 13; 72(23). PMID: 26265181
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.
David H Gardner, Louisa E Jeffery, +4 authors, David M Sansom.
J Immunol, 2015 Aug 16; 195(6). PMID: 26276872    Free PMC article.
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.
Yun Xiao, Guilin Qiao, +6 authors, Jian Zhang.
J Immunol, 2015 Sep 30; 195(9). PMID: 26416283    Free PMC article.
Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand.
Hong-Sheng Lim, Shaun-Paul Cordoba, +4 authors, P Anton van der Merwe.
J Immunol, 2015 Oct 27; 195(11). PMID: 26500347    Free PMC article.
Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction.
Masahiro Tanemura, Eiji Miyoshi, +7 authors, Yuichiro Doki.
World J Gastroenterol, 2015 Nov 03; 21(40). PMID: 26523105    Free PMC article.
MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway.
Wei Sang, Ying Wang, +11 authors, Kailin Xu.
Immunol Lett, 2015 Nov 10; 172. PMID: 26549736    Free PMC article.
Aging, cytomegalovirus (CMV) and influenza vaccine responses.
Daniela Frasca, Bonnie B Blomberg.
Hum Vaccin Immunother, 2015 Nov 21; 12(3). PMID: 26588038    Free PMC article.
CD28-mediated T cell response is upregulated by exogenous application of autologous Hsp70-peptide complex in a tumor-bearing host.
Sanjay Kumar, Pramod Kumar Gautam, Munendra Singh Tomar, Arbind Acharya.
Immunol Res, 2015 Dec 08; 64(1). PMID: 26639355
Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus.
Nils Rother, Johan van der Vlag.
Front Immunol, 2015 Dec 10; 6. PMID: 26648939    Free PMC article.
Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells.
Jonathan P H Fisher, Barry Flutter, +4 authors, John Anderson.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942051    Free PMC article.
MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells.
Mario Martínez Soldevilla, Helena Villanueva, +5 authors, Fernando Pastor.
Oncotarget, 2016 Mar 19; 7(17). PMID: 26992239    Free PMC article.
Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies.
Alistair M Cook, Alison M McDonnell, Richard A Lake, Anna K Nowak.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141331    Free PMC article.
CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo.
Gengwen Tian, Amy N Courtney, +10 authors, Leonid S Metelitsa.
J Clin Invest, 2016 May 18; 126(6). PMID: 27183388    Free PMC article.
Highly Cited.
TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.
Julia Svedova, Naomi Tsurutani, +2 authors, Anthony T Vella.
J Immunol, 2016 May 18; 196(11). PMID: 27183621    Free PMC article.
CD28 Costimulation: From Mechanism to Therapy.
Jonathan H Esensten, Ynes A Helou, +2 authors, Jeffrey A Bluestone.
Immunity, 2016 May 19; 44(5). PMID: 27192564    Free PMC article.
Highly Cited. Review.
Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation.
Nicla Porciello, Martina Kunkl, Antonella Viola, Loretta Tuosto.
Front Immunol, 2016 Jun 01; 7. PMID: 27242793    Free PMC article.
Immunoregulatory pathways following strong inflammatory processes markedly impair CD4+ T cell responses.
Christine M Minnar, William J Murphy.
Hum Vaccin Immunother, 2016 Jul 14; 12(9). PMID: 27409155    Free PMC article.
Flt3 Ligand Treatment Attenuates T Cell Dysfunction and Improves Survival in a Murine Model of Burn Wound Sepsis.
Naeem K Patil, Julia K Bohannon, +5 authors, Edward R Sherwood.
Shock, 2016 Jul 28; 47(1). PMID: 27454384    Free PMC article.
Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
Jessica Dobbins, Etienne Gagnon, +4 authors, Kai W Wucherpfennig.
Sci Signal, 2016 Jul 28; 9(438). PMID: 27460989    Free PMC article.
Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.
Ornella Franzese, Belinda Palermo, +6 authors, Paola Nisticò.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467927    Free PMC article.
Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression.
Naeem K Patil, Julia K Bohannon, Edward R Sherwood.
Pharmacol Res, 2016 Jul 30; 111. PMID: 27468649    Free PMC article.
NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes.
Galaxia M Rodriguez, Diwakar Bobbala, +8 authors, Subburaj Ilangumaran.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471621    Free PMC article.
Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.
Yi Wang, Cindy S Ma, +33 authors, Jean-Laurent Casanova.
J Exp Med, 2016 Nov 05; 213(11). PMID: 27647349    Free PMC article.
[Progress in Immunotherapy for Squamous Non-small Cell Lung Cancer].
Shouzheng Wang, Junling Li.
Zhongguo Fei Ai Za Zhi, 2016 Oct 21; 19(10). PMID: 27760599    Free PMC article.
Unraveling the Role of Allo-Antibodies and Transplant Injury.
Yoshiko Matsuda, Minnie M Sarwal.
Front Immunol, 2016 Nov 08; 7. PMID: 27818660    Free PMC article.
Ipilimumab: from preclinical development to future clinical perspectives in melanoma.
Paul Letendre, Varun Monga, Mohammed Milhem, Yousef Zakharia.
Future Oncol, 2016 Nov 25; 13(7). PMID: 27882779    Free PMC article.
T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca2+ Influx.
Kristin Schmiedeberg, Hardy Krause, +3 authors, Monika C Brunner-Weinzierl.
PLoS One, 2016 Nov 29; 11(11). PMID: 27893767    Free PMC article.
Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders.
Ga Hye Lee, Won-Woo Lee.
Immune Netw, 2016 Dec 31; 16(6). PMID: 28035207    Free PMC article.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.
Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri.
Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974    Free PMC article.
CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond.
ZeNan L Chang, Yvonne Y Chen.
Trends Mol Med, 2017 Apr 19; 23(5). PMID: 28416139    Free PMC article.
Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins.
Jolanda H M van Bilsen, Edyta Sienkiewicz-Szłapka, +15 authors, Erwin L Roggen.
Clin Transl Allergy, 2017 May 17; 7. PMID: 28507730    Free PMC article.
Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters.
Alison M McDonnell, Alistair Cook, +2 authors, Anna K Nowak.
BMC Cancer, 2017 Jun 18; 17(1). PMID: 28619093    Free PMC article.
Engineering CAR-T cells.
Cheng Zhang, Jun Liu, Jiang F Zhong, Xi Zhang.
Biomark Res, 2017 Jun 28; 5. PMID: 28652918    Free PMC article.
Highly Cited. Review.
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.
Gabriela Andrejeva, Jeffrey C Rathmell.
Cell Metab, 2017 Jul 07; 26(1). PMID: 28683294    Free PMC article.
Highly Cited.
Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.
Masashi Watanabe, Chiharu Fujihara, +4 authors, Richard J Hodes.
J Exp Med, 2017 Aug 05; 214(9). PMID: 28768709    Free PMC article.
Increased Neutralizing Antibody Production and Interferon-γ Secretion in Response to Porcine Reproductive and Respiratory Syndrome Virus Immunization in Genetically Modified Pigs.
Guangping Huang, Xianyong Liu, +6 authors, Xun Suo.
Front Immunol, 2017 Sep 29; 8. PMID: 28955336    Free PMC article.
Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan.
Ahmad F Karim, Obondo J Sande, +8 authors, W Henry Boom.
Proteomics, 2017 Oct 11; 17(22). PMID: 28994205    Free PMC article.
Aptamer-Based Therapeutic Approaches to Target Cancer Stem Cells.
Gang Zhou, Olivier Latchoumanin, +5 authors, Liang Qiao.
Theranostics, 2017 Nov 08; 7(16). PMID: 29109790    Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation.
Sara Zumerle, Barbara Molon, Antonella Viola.
Front Immunol, 2017 Nov 23; 8. PMID: 29163534    Free PMC article.
Introducing Membrane Charge and Membrane Potential to T Cell Signaling.
Yuanqing Ma, Kate Poole, Jesse Goyette, Katharina Gaus.
Front Immunol, 2017 Nov 25; 8. PMID: 29170669    Free PMC article.
Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation.
Nicholas Jones, James G Cronin, +7 authors, Nigel J Francis.
Front Immunol, 2017 Nov 25; 8. PMID: 29170670    Free PMC article.
A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells.
Talal A Chatila, Raffaele De Palma.
Eur J Immunol, 2017 Dec 07; 47(12). PMID: 29211935    Free PMC article.
Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.
Mohamed Mahgoub, Jun-Ichirou Yasunaga, +4 authors, Masao Matsuoka.
Proc Natl Acad Sci U S A, 2018 Jan 24; 115(6). PMID: 29358408    Free PMC article.
Highly Cited.
Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists.
Christopher T Petersen, Mojibade Hassan, +9 authors, Edmund K Waller.
Blood Adv, 2018 Feb 02; 2(3). PMID: 29386194    Free PMC article.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.
Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson.
PLoS One, 2018 Apr 05; 13(4). PMID: 29617360    Free PMC article.
Posttranscriptional regulation of T helper cell fate decisions.
Kai P Hoefig, Vigo Heissmeyer.
J Cell Biol, 2018 Apr 25; 217(8). PMID: 29685903    Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens.
Jeremy D Waight, Dhan Chand, +14 authors, Nicholas S Wilson.
Cancer Cell, 2018 Jun 13; 33(6). PMID: 29894690    Free PMC article.
CD28 between tolerance and autoimmunity: the side effects of animal models.
Nicla Porciello, Martina Kunkl, Loretta Tuosto.
F1000Res, 2018 Jun 16; 7. PMID: 29904580    Free PMC article.
CD4+CD28null T Lymphocytes are Associated with the Development of Atrial Fibrillation after Elective Cardiac Surgery.
Patrick Sulzgruber, Barbara Thaler, +11 authors, Alexander Niessner.
Sci Rep, 2018 Jun 27; 8(1). PMID: 29941960    Free PMC article.
Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.
Anisur Rahman, Abhinav Tiwari, Jatin Narula, Timothy Hickling.
CPT Pharmacometrics Syst Pharmacol, 2018 Sep 11; 7(10). PMID: 30198637    Free PMC article.
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency.
Immacolata Brigida, Matteo Zoccolillo, +43 authors, Alessandro Aiuti.
Blood, 2018 Sep 27; 132(22). PMID: 30254128    Free PMC article.
Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS Prodigy system.
Wei Zhang, Kimberly R Jordan, Brian Schulte, Enkhtsetseg Purev.
Drug Des Devel Ther, 2018 Oct 17; 12. PMID: 30323566    Free PMC article.
Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses.
Emad I Wafa, Sean M Geary, +3 authors, Aliasger K Salem.
J Pharmacol Exp Ther, 2018 Oct 27; 370(3). PMID: 30361239    Free PMC article.
Altered Cd8+ T lymphocyte Response Triggered by Arginase 1: Implication for Fatigue Intensification during Localized Radiation Therapy in Prostate Cancer Patients.
Leorey N Saligan, Nada Lukkahatai, +2 authors, Xiao-Min Wang.
Neuropsychiatry (London), 2018 Oct 27; 8(4). PMID: 30364895    Free PMC article.
Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory.
Sophie Viaud, Jennifer S Y Ma, +10 authors, Travis S Young.
Proc Natl Acad Sci U S A, 2018 Oct 31; 115(46). PMID: 30373813    Free PMC article.
Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients.
Belinda Palermo, Ornella Franzese, +9 authors, Paola Nisticò.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524882    Free PMC article.
Pentaerythritol-based lipid A bolsters the antitumor efficacy of a polyanhydride particle-based cancer vaccine.
Emad I Wafa, Sean M Geary, +3 authors, Aliasger K Salem.
Nanomedicine, 2019 Jul 19; 21. PMID: 31319179    Free PMC article.
Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis.
Qian Li, Yan Yan, +8 authors, Mengji Lu.
Front Immunol, 2019 Oct 02; 10. PMID: 31572396    Free PMC article.
Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer.
Peter Wierstra, Gerwin Sandker, +5 authors, Sandra Heskamp.
EJNMMI Radiopharm Chem, 2019 Nov 07; 4(1). PMID: 31696402    Free PMC article.
The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma.
Peng Liao, Haofan Wang, +2 authors, Xin-Hua Liang.
Front Immunol, 2019 Nov 12; 10. PMID: 31708918    Free PMC article.
Deoxynivalenol Affects Proliferation and Expression of Activation-Related Molecules in Major Porcine T-Cell Subsets.
Eleni Vatzia, Alix Pierron, +2 authors, Wilhelm Gerner.
Toxins (Basel), 2019 Nov 07; 11(11). PMID: 31694331    Free PMC article.
Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C.
Samuel D Shin, Alexandra Shin, +5 authors, Salvador Soriano.
J Neuroinflammation, 2019 Dec 19; 16(1). PMID: 31847862    Free PMC article.
The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy.
Jessica Michie, Conor J Kearney, +2 authors, Jane Oliaro.
Cells, 2020 Jan 18; 9(1). PMID: 31947615    Free PMC article.
Relationship of Peripheral Lymphocyte Subsets and Skeletal Muscle Mass Index in Sarcopenia: A Cross-Sectional Study.
S-W Huang, T Xu, C-T Zhang, H-L Zhou.
J Nutr Health Aging, 2020 Mar 03; 24(3). PMID: 32115615
Teaching an old dog new tricks: next-generation CAR T cells.
Nicholas Tokarew, Justyna Ogonek, +2 authors, Sebastian Kobold.
Br J Cancer, 2018 Nov 11; 120(1). PMID: 30413825    Free PMC article.
Highly Cited. Review.
Cheating the Hunger Games; Mechanisms Controlling Clonal Diversity of CD8 Effector and Memory Populations.
Inga Kavazović, Bojan Polić, Felix M Wensveen.
Front Immunol, 2018 Dec 18; 9. PMID: 30555492    Free PMC article.
TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells.
Fan Xia, Cheng-Rui Qian, +10 authors, Hai-Tao He.
Front Immunol, 2018 Dec 20; 9. PMID: 30564247    Free PMC article.
Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor.
Rongxue Wan, Jenny Wu, +11 authors, Shaoying Lu.
Sci Adv, 2019 Jun 22; 5(6). PMID: 31223643    Free PMC article.
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
Matthew F Pech, Linda E Fong, +7 authors, Jeffrey Settleman.
Elife, 2019 Aug 28; 8. PMID: 31452512    Free PMC article.
Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy.
Jinyu Zhang, Pablo Saenz-Lopez Larrocha, +3 authors, Jennifer D Wu.
J Immunother Cancer, 2019 Aug 27; 7(1). PMID: 31446896    Free PMC article.
Anaphylaxis-induced atrial fibrillation and anesthesia: Pathophysiologic and therapeutic considerations.
Nicholas G Kounis, Ioanna Koniari, +3 authors, George Hahalis.
Ann Card Anaesth, 2020 Jan 14; 23(1). PMID: 31929239    Free PMC article.
Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity.
Kuan Rong Chan, Xiaohui Wang, +14 authors, Eng Eong Ooi.
Nat Microbiol, 2016 Sep 20; 1. PMID: 27642668    Free PMC article.
Regulation of immune responses by E3 ubiquitin ligase Cbl-b.
Rong Tang, Wallace Y Langdon, Jian Zhang.
Cell Immunol, 2018 Nov 18; 340. PMID: 30442330    Free PMC article.
Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma.
Chune Yu, Xiaowei Liu, +4 authors, Hubing Shi.
Front Immunol, 2019 May 28; 10. PMID: 31134073    Free PMC article.
Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives.
Stefania Raimondo, Marzia Pucci, Riccardo Alessandro, Simona Fontana.
Int J Mol Sci, 2020 Apr 01; 21(7). PMID: 32225076    Free PMC article.
ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation.
Jennifer A Rohrs, Elizabeth L Siegler, Pin Wang, Stacey D Finley.
iScience, 2020 Apr 24; 23(4). PMID: 32325413    Free PMC article.
CD28 null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection.
Aalia Bano, Alejandra Pera, +4 authors, Florian Kern.
F1000Res, 2019 Apr 16; 8. PMID: 30984377    Free PMC article.
Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells.
Rowa Y Alhabbab.
Front Genet, 2020 May 12; 11. PMID: 32391048    Free PMC article.
T cell immunotherapy enhanced by designer biomaterials.
Zachary S Dunn, John Mac, Pin Wang.
Biomaterials, 2019 Jul 05; 217. PMID: 31271861    Free PMC article.
CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells.
Ankita Mitra, Sudarvili Shanthalingam, +10 authors, Barbara A Osborne.
Front Immunol, 2020 May 28; 11. PMID: 32457739    Free PMC article.
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer.
Laura Garcia Perez, Jan Kempski, +21 authors, Samuel Huber.
Nat Commun, 2020 May 27; 11(1). PMID: 32451418    Free PMC article.
Recent Advances: The Imbalance of Immune Cells and Cytokines in the Pathogenesis of Hepatocellular Carcinoma.
Kumar Jayant, Nagy Habib, +2 authors, Ramesh Arasaradnam.
Diagnostics (Basel), 2020 May 30; 10(5). PMID: 32466214    Free PMC article.
CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.
Gaëtan Blaize, Hélène Daniels-Treffandier, +13 authors, Renaud Lesourne.
Proc Natl Acad Sci U S A, 2020 May 22; 117(23). PMID: 32434911    Free PMC article.
Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions.
Xianhui Meng, Ruirui Jing, +2 authors, Jie Sun.
Front Immunol, 2020 Jul 09; 11. PMID: 32636832    Free PMC article.
The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation.
Jian Wu, Lu Xia, +17 authors, Xin-Zhuan Su.
Proc Natl Acad Sci U S A, 2020 Jul 02; 117(28). PMID: 32606244    Free PMC article.
Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors.
Alexandre Perrier, Audrey Didelot, +2 authors, Simon Garinet.
Biomolecules, 2020 Jul 28; 10(7). PMID: 32708698    Free PMC article.
Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders.
Bernard Vanhove, Nicolas Poirier, +9 authors, Gilles Blancho.
Antibodies (Basel), 2017 Nov 21; 6(4). PMID: 31548534    Free PMC article.
Helpless Priming Sends CD8+ T Cells on the Road to Exhaustion.
Julia Busselaar, Sun Tian, Hans van Eenennaam, Jannie Borst.
Front Immunol, 2020 Oct 31; 11. PMID: 33123174    Free PMC article.
Regulation of SATB1 during thymocyte development by TCR signaling.
Kamalvishnu P Gottimukkala, Rahul Jangid, +4 authors, Sanjeev Galande.
Mol Immunol, 2016 Jul 28; 77. PMID: 27454343    Free PMC article.
The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease.
Cornelia M Weyand, Gerald J Berry, Jörg J Goronzy.
J Leukoc Biol, 2017 Aug 30; 103(3). PMID: 28848042    Free PMC article.
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Judith Feucht, Jie Sun, +7 authors, Michel Sadelain.
Nat Med, 2018 Dec 19; 25(1). PMID: 30559421    Free PMC article.
Highly Cited.
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Masashi Watanabe, Ying Lu, Michael Breen, Richard J Hodes.
Nat Commun, 2020 Dec 10; 11(1). PMID: 33293517    Free PMC article.
'Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity.
Sanne C Lith, Bram W van Os, Tom T P Seijkens, Carlie J M de Vries.
Eur J Immunol, 2020 Oct 17; 50(11). PMID: 33063848    Free PMC article.
Targeting ubiquitin signaling for cancer immunotherapy.
Xiaofei Zhou, Shao-Cong Sun.
Signal Transduct Target Ther, 2021 Jan 14; 6(1). PMID: 33436547    Free PMC article.
CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors.
Huanpeng Chen, Fengjiao Wei, +4 authors, Zhaofeng Huang.
Cancer Immunol Immunother, 2021 Jan 14; 70(7). PMID: 33439295
The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies.
Lijuan Zhao, Qi Wang, +2 authors, Honglin Zhu.
Aging Dis, 2021 Feb 04; 12(1). PMID: 33532139    Free PMC article.
Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation.
Sander de Kivit, Mark Mensink, +7 authors, Jannie Borst.
Nat Metab, 2020 Sep 23; 2(10). PMID: 32958937
ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis.
Timoteo Marchini, Sophie Hansen, Dennis Wolf.
Cells, 2021 Mar 07; 10(2). PMID: 33669769    Free PMC article.
Innate immune receptor clustering and its role in immune regulation.
Miao Li, Yan Yu.
J Cell Sci, 2021 Feb 19; 134(4). PMID: 33597156    Free PMC article.
The Role of O-GlcNAcylation in Immune Cell Activation.
Amy Qiang, Chad Slawson, Patrick E Fields.
Front Endocrinol (Lausanne), 2021 May 15; 12. PMID: 33986724    Free PMC article.
Insulin Signaling in Arthritis.
Cesare Tripolino, Jacopo Ciaffi, +6 authors, Francesco Ursini.
Front Immunol, 2021 May 18; 12. PMID: 33995414    Free PMC article.
CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells.
Yo-Ping Lai, Lu-Cheng Kuo, +13 authors, Shu-Ching Chen.
Commun Biol, 2021 May 21; 4(1). PMID: 34011962    Free PMC article.
Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena.
Luis González-Osuna, Alfredo Sierra-Cristancho, +4 authors, Rolando Vernal.
Aging Dis, 2021 Aug 04; 12(5). PMID: 34341698    Free PMC article.
Characterization of local and peripheral immune system in pregnant and nonpregnant ewes.
Laurel D Quirke, Paul H Maclean, +3 authors, Jennifer L Juengel.
J Anim Sci, 2021 Jul 10; 99(8). PMID: 34240172    Free PMC article.
IgG Immune Complexes Inhibit Naïve T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells.
Wissam Charab, Matthew G Rosenberger, +8 authors, George Georgiou.
Front Immunol, 2021 Aug 28; 12. PMID: 34447380    Free PMC article.
Onchocerciasis Fingerprints in the Geriatric Population: Does Host Immunity Play a Role?
Cabirou Mounchili Shintouo, Robert Adamu Shey, +4 authors, Rose Njemini.
Trop Med Infect Dis, 2021 Aug 28; 6(3). PMID: 34449738    Free PMC article.
Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules.
Martina Kunkl, Carola Amormino, +6 authors, Loretta Tuosto.
Front Immunol, 2021 Sep 08; 12. PMID: 34489975    Free PMC article.
Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy.
Shubhangi Gavali, Jianing Liu, Xinyi Li, Magdalena Paolino.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639141    Free PMC article.
Virus in the pathogenesis of inflammatory bowel disease: role of Toll-like receptor 7/8/3.
Hamid Asadzadeh Aghdaei, Negar Jamshidi, +3 authors, Mohammad Reza Zali.
Gastroenterol Hepatol Bed Bench, 2021 Oct 19; 14(4). PMID: 34659656    Free PMC article.
Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients.
Mia J Coleman, Kourtney M Zimmerly, Xuexian O Yang.
Biomolecules, 2021 Oct 24; 11(10). PMID: 34680058    Free PMC article.
A T-Cell Epitope-Based Multi-Epitope Vaccine Designed Using Human HLA Specific T Cell Epitopes Induces a Near-Sterile Immunity against Experimental Visceral Leishmaniasis in Hamsters.
Aryandra Arya, Sunil K Arora.
Vaccines (Basel), 2021 Oct 27; 9(10). PMID: 34696166    Free PMC article.
Bacterial lectin BambL acts as a B cell superantigen.
Marco Frensch, Christina Jäger, +9 authors, Winfried Römer.
Cell Mol Life Sci, 2021 Nov 04; 78(24). PMID: 34731252    Free PMC article.
Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy.
Luis Felipe Olguín-Contreras, Anna N Mendler, +2 authors, Elfriede Noessner.
Front Immunol, 2021 Dec 17; 12. PMID: 34912334    Free PMC article.
Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier.
Somayeh Vafaei, Angelina O Zekiy, +4 authors, Majid Zamani.
Cancer Cell Int, 2022 Jan 05; 22(1). PMID: 34980128    Free PMC article.
Imaging Membrane Order and Dynamic Interactions in Living Cells with a DNA Zipper Probe.
Yousef Bagheri, Ahsan Ausaf Ali, +3 authors, Mingxu You.
Angew Chem Int Ed Engl, 2021 Nov 13; 61(6). PMID: 34767659    Free PMC article.
Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors.
Yosuke Dotsu, Daisuk Muraoka, +7 authors, Hiroaki Ikeda.
J Immunother Cancer, 2022 Feb 05; 10(2). PMID: 35115364    Free PMC article.
DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms.
Anjun Jiao, Chenming Sun, +11 authors, Baojun Zhang.
Sci Adv, 2022 Feb 10; 8(6). PMID: 35138904    Free PMC article.
Senescent CD4+CD28- T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis.
Luis González-Osuna, Alfredo Sierra-Cristancho, +5 authors, Rolando Vernal.
Int J Mol Sci, 2022 Mar 11; 23(5). PMID: 35269683    Free PMC article.
Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons.
Adel Naimi, Rebar N Mohammed, +11 authors, Ehsan Razeghian.
Cell Commun Signal, 2022 Apr 09; 20(1). PMID: 35392976    Free PMC article.
c-Met-targeted chimeric antigen receptor T cells inhibit hepatocellular carcinoma cells in vitro and in vivo.
Xiaochen Huang, Jiaojiao Guo, +5 authors, Zhenqing Feng.
J Biomed Res, 2022 Apr 12; 36(1). PMID: 35403606    Free PMC article.
Agents of cancer immunosurveillance: HSPs and dsDNA.
Devanshi A Nayak, Robert J Binder.
Trends Immunol, 2022 Apr 07; 43(5). PMID: 35382994    Free PMC article.
CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.
Chao Yang, Mahesh Bachu, +6 authors, Lionel B Ivashkiv.
Nat Commun, 2022 Jun 15; 13(1). PMID: 35701499