Journal Article
. 2003 Dec; 254(1-2):163-72.
doi: 10.1023/a:1027321130997.

Partial prevention of changes in SR gene expression in congestive heart failure due to myocardial infarction by enalapril or losartan

Xiaobing Guo 1 Donald Chapman  Naranjan S Dhalla  
Affiliations
  • PMID: 14674695
  •     51 References
  •     9 citations

Abstract

Although activation of the renin-angiotensin system (RAS) is known to produce ventricular remodeling and congestive heart failure (CHF), its role in inducing changes in the sarcoplasmic reticulum (SR) protein and gene expression in CHF is not fully understood. In this study, CHF was induced in rats by ligation of the left coronary artery for 3 weeks and then the animals were treated orally with or without an angiotensin converting enzyme inhibitor, enalapril (10 mg/kg/day) or an angiotensin II receptor antagonist, losartan (20 mg/kg/day) for 4 weeks. Sham-operated animals were used as control. The animals were hemodynamically assessed and protein content as well as gene expression of SR Ca(2+)-release channel (ryanodine receptor, RYR), Ca(2+)-pump ATPase (SERCA2), phospholamban (PLB) and calsequestrin (CQS) were determined in the left ventricle (LV). The infarcted animals showed cardiac hypertrophy, lung congestion, depression in LV +dP/dt and -dP/dt, as well as increase in LV end diastolic pressure. Both protein content and mRNA levels for RYR, SERCA2 and PLB were decreased without any changes in CQS in the failing heart. These alterations in LV function as well as SR protein and gene expression in CHF were partially prevented by treatment with enalapril or losartan. The results suggest that partial improvement in LV function by enalapril and losartan treatments may be due to partial prevention of changes in SR protein and gene expression in CHF and that these effects may be due to blockade of the RAS.

Mechanisms of cardiomyocyte dysfunction in heart failure following myocardial infarction in rats.
E Holt, T Tønnessen, +4 authors, G Christensen.
J Mol Cell Cardiol, 1998 Sep 17; 30(8). PMID: 9737944
Isolated myocyte contractile function is normal in postinfarct remodeled rat heart with systolic dysfunction.
I S Anand, D Liu, +5 authors, Y Chandrashekhar.
Circulation, 1997 Dec 24; 96(11). PMID: 9403622
Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure.
S Kim, M Yoshiyama, +4 authors, H Iwao.
Circulation, 2001 Jan 04; 103(1). PMID: 11136700
Sprint training normalizes Ca(2+) transients and SR function in postinfarction rat myocytes.
L Q Zhang, X Q Zhang, +4 authors, J Y Cheung.
J Appl Physiol (1985), 2000 Jul 25; 89(1). PMID: 10904033
Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.
G Hasenfuss, H Reinecke, +7 authors, H Drexler.
Circ Res, 1994 Sep 01; 75(3). PMID: 8062417
Highly Cited.
Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium.
J K Gwathmey, M T Slawsky, +2 authors, J P Morgan.
J Clin Invest, 1990 May 01; 85(5). PMID: 2332508    Free PMC article.
Cytosolic calcium transients in myocytes isolated from rats with ischemic heart failure.
J M Capasso, P Li, P Anversa.
Am J Physiol, 1993 Dec 01; 265(6 Pt 2). PMID: 8285234
Post-infarction heart failure in the rat is associated with distinct alterations in cardiac myocyte molecular phenotype.
P Yue, C S Long, +3 authors, B M Massie.
J Mol Cell Cardiol, 1998 Sep 17; 30(8). PMID: 9737947
In situ SR function in postinfarction myocytes.
X Q Zhang, Y C Ng, +2 authors, J Y Cheung.
J Appl Physiol (1985), 1999 Dec 22; 87(6). PMID: 10601161
Cardiac angiotensin II formation in the clinical course of heart failure and its relationship with left ventricular function.
G G Serneri, M Boddi, +9 authors, P A Modesti.
Circ Res, 2001 May 23; 88(9). PMID: 11349007
Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.
J J Mercadier, A M Lompré, +6 authors, K Schwartz.
J Clin Invest, 1990 Jan 01; 85(1). PMID: 2136864    Free PMC article.
Highly Cited.
Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats.
K Iijima, E Geshi, +2 authors, T Katagiri.
Jpn Circ J, 1998 Jul 04; 62(6). PMID: 9652322
Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy.
M Meyer, W Schillinger, +7 authors, G Hasenfuss.
Circulation, 1995 Aug 15; 92(4). PMID: 7641356
Highly Cited.
Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.
D de la Bastie, D Levitsky, +6 authors, A M Lompré.
Circ Res, 1990 Feb 01; 66(2). PMID: 2137041
Differential changes in left and right ventricular SR calcium transport in congestive heart failure.
N Afzal, N S Dhalla.
Am J Physiol, 1992 Mar 01; 262(3 Pt 2). PMID: 1313649
Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat.
K Ojamaa, A Kenessey, R Shenoy, I Klein.
Am J Physiol Endocrinol Metab, 2000 Nov 30; 279(6). PMID: 11093920
Decreased expression of cardiac sarcoplasmic reticulum Ca(2+)-pump ATPase in congestive heart failure due to myocardial infarction.
A Zarain-Herzberg, N Afzal, V Elimban, N S Dhalla.
Mol Cell Biochem, 1996 Oct 01; 163-164. PMID: 8974068
Myocyte performance during evolution of myocardial infarction in rats: effects of propionyl-L-carnitine.
P Li, C Park, +5 authors, G Bianchi.
Am J Physiol, 1995 Apr 01; 268(4 Pt 2). PMID: 7733374
Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure.
J P Morgan, R E Erny, +2 authors, J K Gwathmey.
Circulation, 1990 Feb 01; 81(2 Suppl). PMID: 2153479
Captopril treatment improves the sarcoplasmic reticular Ca(2+) transport in heart failure due to myocardial infarction.
Q Shao, B Ren, +2 authors, N S Dhalla.
J Mol Cell Cardiol, 1999 Sep 02; 31(9). PMID: 10471350
Sarcoplasmic reticular Ca2+ pump ATPase activity in congestive heart failure due to myocardial infarction.
N Afzal, N S Dhalla.
Can J Cardiol, 1996 Oct 01; 12(10). PMID: 9191500
Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction.
K Yonekura, Y Eto, +7 authors, T Aoyagi.
Basic Res Cardiol, 2000 Dec 01; 95(5). PMID: 11099160
Differences in time course of myocardial mRNA expression in non-infarcted myocardium after myocardial infarction.
T Omura, M Yoshiyama, +6 authors, J Yoshikawa.
Basic Res Cardiol, 2000 Sep 27; 95(4). PMID: 11005587
Effect of cilazapril on ventricular remodeling assessed by Doppler-echocardiographic assessment and cardiac gene expression.
M Yoshiyama, K Takeuchi, +7 authors, J Yoshikawa.
Cardiovasc Drugs Ther, 1998 Jun 02; 12(1). PMID: 9607133
Calcium movements in relation to heart function.
N S Dhalla, G N Pierce, +2 authors, R E Beamish.
Basic Res Cardiol, 1982 Mar 01; 77(2). PMID: 6284117
Review.
Nitrendipine binding in congestive heart failure due to myocardial infarction.
I M Dixon, S L Lee, N S Dhalla.
Circ Res, 1990 Mar 01; 66(3). PMID: 2155068
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
R Sethi, V Elimban, +2 authors, N S Dhalla.
J Mol Cell Cardiol, 1999 Jan 30; 30(11). PMID: 9925353
Myocardial infarct size and ventricular function in rats.
M A Pfeffer, J M Pfeffer, +4 authors, E Braunwald.
Circ Res, 1979 Apr 01; 44(4). PMID: 428047
Highly Cited.
Early versus delayed angiotensin-converting enzyme inhibition in experimental chronic heart failure. Effects on survival, hemodynamics, and cardiovascular remodeling.
P Mulder, B Devaux, +5 authors, C Thuillez.
Circulation, 1997 Mar 04; 95(5). PMID: 9054865
Maximal inhibition of SERCA2 Ca(2+) affinity by phospholamban in transgenic hearts overexpressing a non-phosphorylatable form of phospholamban.
A G Brittsan, A N Carr, A G Schmidt, E G Kranias.
J Biol Chem, 2000 Apr 15; 275(16). PMID: 10766848
Modification of myosin gene expression by imidapril in failing heart due to myocardial infarction.
Jingwei Wang, Xueliang Liu, +3 authors, Naranjan S Dhalla.
J Mol Cell Cardiol, 2002 Jul 09; 34(7). PMID: 12099723
Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure.
M Arai, H Matsui, M Periasamy.
Circ Res, 1994 Apr 01; 74(4). PMID: 8137493
Review.
Hemodynamic benefits and prolonged survival with long-term captopril therapy in rats with myocardial infarction and heart failure.
J M Pfeffer, M A Pfeffer, E Braunwald.
Circulation, 1987 Jan 01; 75(1 Pt 2). PMID: 3539404
Angiotensin-converting enzyme inhibition improves cardiac function. Role of bradykinin.
P Gohlke, W Linz, +4 authors, T Unger.
Hypertension, 1994 Apr 01; 23(4). PMID: 8144208
Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction.
Jingwei Wang, Xueliang Liu, +2 authors, Naranjan S Dhalla.
Am J Physiol Heart Circ Physiol, 2003 May 14; 284(6). PMID: 12742831
Angiotensin type 1 receptor antagonism with irbesartan inhibits ventricular hypertrophy and improves diastolic function in the remodeling post-myocardial infarction ventricle.
J Ambrose, D G Pribnow, +3 authors, B H Greenberg.
J Cardiovasc Pharmacol, 1999 Mar 09; 33(3). PMID: 10069680
Myocyte contractile function is intact in the post-infarct remodeled rat heart despite molecular alterations.
S Gupta, A J Prahash, I S Anand.
Cardiovasc Res, 2000 Oct 18; 48(1). PMID: 11033110
Captopril enhances intracellular calcium handling and beta-adrenergic responsiveness of myocardium from rats with postinfarction failure.
S E Litwin, J P Morgan.
Circ Res, 1992 Oct 01; 71(4). PMID: 1325296
Modulation of oxidative stress by a selective inhibition of angiotensin II type 1 receptors in MI rats.
N Khaper, P K Singal.
J Am Coll Cardiol, 2001 Apr 13; 37(5). PMID: 11300462
Chronic effects of enalapril and amlodipine on cardiac remodeling in cardiomyopathic hamster hearts.
M Watanabe, H Kawaguchi, +6 authors, A Kitabatake.
J Cardiovasc Pharmacol, 1998 Aug 13; 32(2). PMID: 9700987
Effects of captopril therapy after late reperfusion on left ventricular remodeling after experimental myocardial infarction.
P Jain, G Korlipara, +3 authors, P F Cohn.
Am Heart J, 1994 Apr 01; 127(4 Pt 1). PMID: 8154412
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
P Chomczynski, N Sacchi.
Anal Biochem, 1987 Apr 01; 162(1). PMID: 2440339
Highly Cited.
Left ventricular dilatation after myocardial infarction: ACE inhibitors, beta-blockers, or both?
R L Anthonio, D J van Veldhuisen, W H van Gilst.
J Cardiovasc Pharmacol, 1998 Sep 10; 32 Suppl 1. PMID: 9731689
Review.
Prevention of abnormal sarcoplasmic reticulum calcium transport and protein expression in post-infarction heart failure using 3, 5-diiodothyropropionic acid (DITPA).
G D Pennock, P H Spooner, C E Summers, S E Litwin.
J Mol Cell Cardiol, 2000 Oct 21; 32(11). PMID: 11040100
Pathophysiology of cardiac dysfunction in congestive heart failure.
N S Dhalla, N Afzal, +3 authors, M Nagano.
Can J Cardiol, 1993 Dec 01; 9(10). PMID: 8281476
Review.
Effects of stimulation frequency on calcium transients in noninfarcted myocardium: modulation by chronic captopril treatment.
S E Litwin, J P Morgan.
J Card Fail, 1999 Sep 25; 5(3). PMID: 10496195
Angiotensin II type 1-receptor antagonist candesartan cilexitil prevents left ventricular dysfunction in myocardial infarcted rats.
A Hanatani, M Yoshiyama, +5 authors, J Yoshikawa.
Jpn J Pharmacol, 1998 Nov 06; 78(1). PMID: 9804061
Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts.
R H Schwinger, M Böhm, +5 authors, E Erdmann.
Circulation, 1995 Dec 01; 92(11). PMID: 7586307
Impaired cardiac function in rats with healed myocardial infarction: cellular vs. myocardial mechanisms.
J Y Cheung, T I Musch, +4 authors, R L Moore.
Am J Physiol, 1994 Jan 01; 266(1 Pt 1). PMID: 8304424
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.
M I Miyamoto, F del Monte, +7 authors, R J Hajjar.
Proc Natl Acad Sci U S A, 2000 Jan 19; 97(2). PMID: 10639159    Free PMC article.
Highly Cited.
Effects of long-term treatment with trandolapril on sarcoplasmic reticulum function of cardiac muscle in rats with chronic heart failure following myocardial infarction.
F Yamaguchi, A Sanbe, S Takeo.
Br J Pharmacol, 1998 Mar 07; 123(2). PMID: 9489622    Free PMC article.
Imidapril treatment improves the attenuated inotropic and intracellular calcium responses to ATP in heart failure due to myocardial infarction.
Harjot K Saini, Qiming Shao, +3 authors, Naranjan S Dhalla.
Br J Pharmacol, 2005 Jan 25; 144(2). PMID: 15665860    Free PMC article.
SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects.
Simona Vittorini, Simona Storti, +2 authors, Aldo Clerico.
Mol Med, 2007 May 23; 13(1-2). PMID: 17515962    Free PMC article.
Antiplatelet therapy attenuates subcellular remodelling in congestive heart failure.
Santosh K Sanganalmath, Andrea P Babick, +3 authors, Naranjan S Dhalla.
J Cell Mol Med, 2007 Dec 20; 12(5A). PMID: 18088389    Free PMC article.
ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction.
S Zalvidea, L André, +9 authors, S Richard.
Curr Mol Med, 2012 Jan 28; 12(2). PMID: 22280358    Free PMC article.
Reversal of subcellular remodelling by losartan in heart failure due to myocardial infarction.
Andrea Babick, Donald Chapman, +2 authors, Naranjan S Dhalla.
J Cell Mol Med, 2012 Sep 06; 16(12). PMID: 22947202    Free PMC article.
Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy.
Changwon Kho, Ahyoung Lee, Roger J Hajjar.
Nat Rev Cardiol, 2012 Oct 24; 9(12). PMID: 23090087    Free PMC article.
Review.
Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models.
Sun Ha Lim, Yaesil Kim, +4 authors, Jongwon Lee.
Sci Rep, 2016 Dec 09; 6. PMID: 27929093    Free PMC article.
Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage.
Benedict Reilly-O'Donnell, Gavin B Robertson, +6 authors, Samantha J Pitt.
J Biol Chem, 2017 Jun 21; 292(32). PMID: 28630041    Free PMC article.
Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels.
Raminta Vaiciuleviciute, Daiva Bironaite, +2 authors, Eiva Bernotiene.
Cells, 2021 Oct 24; 10(10). PMID: 34685552    Free PMC article.
Review.