Journal Article
. 2004 Jan;2(2).
doi: 10.1371/journal.pbio.0020007.

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds

Howard Y Chang 1 Julie B Sneddon  Ash A Alizadeh  Ruchira Sood  Rob B West  Kelli Montgomery  Jen-Tsan Chi  Matt van de Rijn  David Botstein  Patrick O Brown  
  • PMID: 14737219
  •     45 References
  •     382 citations


Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes and their prognostic implications are unclear. In this study, based on gene expression profiles of fibroblasts from ten anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in wound healing. The genes comprising this fibroblast common serum response are coordinately regulated in many human tumors, allowing us to identify tumors with gene expression signatures suggestive of active wounds. Genes induced in the fibroblast serum-response program are expressed in tumors by the tumor cells themselves, by tumor-associated fibroblasts, or both. The molecular features that define this wound-like phenotype are evident at an early clinical stage, persist during treatment, and predict increased risk of metastasis and death in breast, lung, and gastric carcinomas. Thus, the transcriptional signature of the response of fibroblasts to serum provides a possible link between cancer progression and wound healing, as well as a powerful predictor of the clinical course in several common carcinomas.

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PLoS Genet, 2008 Jul 19; 4(7). PMID: 18636107    Free PMC article.
Scleroderma gene expression and pathway signatures.
Jennifer L Sargent, Ausra Milano, M K Connolly, Michael L Whitfield.
Curr Rheumatol Rep, 2008 Jul 22; 10(3). PMID: 18638428
Regulating the angiogenic balance in tissues.
Elizabeth A Pollina, Aster Legesse-Miller, +3 authors, Hilary A Coller.
Cell Cycle, 2008 Jul 22; 7(13). PMID: 18642446    Free PMC article.
Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures.
Pratyaksha Wirapati, Christos Sotiriou, +10 authors, Mauro Delorenzi.
Breast Cancer Res, 2008 Jul 30; 10(4). PMID: 18662380    Free PMC article.
Highly Cited.
Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling.
Catelijne Stortelers, Ron Kerkhoven, Wouter H Moolenaar.
BMC Genomics, 2008 Aug 16; 9. PMID: 18702810    Free PMC article.
Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification.
Dimitry S A Nuyten, Trevor Hastie, +2 authors, Marc J van de Vijver.
Eur J Cancer, 2008 Aug 22; 44(15). PMID: 18715778    Free PMC article.
Comparison of prognostic gene expression signatures for breast cancer.
Benjamin Haibe-Kains, Christine Desmedt, +6 authors, Christos Sotiriou.
BMC Genomics, 2008 Aug 23; 9. PMID: 18717985    Free PMC article.
Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis.
Chad J Creighton, Angelo Casa, +5 authors, Adrian V Lee.
J Clin Oncol, 2008 Sep 02; 26(25). PMID: 18757322    Free PMC article.
Highly Cited.
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers.
Nancy Dumont, Matthew B Wilson, +3 authors, Thea D Tlsty.
Proc Natl Acad Sci U S A, 2008 Sep 23; 105(39). PMID: 18806226    Free PMC article.
Three-dimensional context regulation of metastasis.
Janine T Erler, Valerie M Weaver.
Clin Exp Metastasis, 2008 Sep 25; 26(1). PMID: 18814043    Free PMC article.
Highly Cited. Review.
Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells.
Chris Cheadle, Maria Nesterova, +5 authors, Yoon S Cho-Chung.
BMC Med Genomics, 2008 Sep 30; 1. PMID: 18822129    Free PMC article.
Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.
Hans Neubauer, Susan E Clare, +9 authors, Michael A Cahill.
Breast Cancer Res, 2008 Oct 17; 10(5). PMID: 18922159    Free PMC article.
Gene expression profiling of breast cancer.
Ting Bao, Nancy E Davidson.
Adv Surg, 2008 Oct 29; 42. PMID: 18953822    Free PMC article.
Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types.
M H W Starmans, B Krishnapuram, +8 authors, P Lambin.
Br J Cancer, 2008 Nov 06; 99(11). PMID: 18985037    Free PMC article.
Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with better [corrected] prognosis.
Vassiliki Tzelepi, Petros Grivas, +3 authors, Georgia Sotiropoulou-Bonikou.
Virchows Arch, 2008 Dec 03; 454(1). PMID: 19048289
The genomic analysis of lactic acidosis and acidosis response in human cancers.
Julia Ling-Yu Chen, Joseph E Lucas, +6 authors, Jen-Tsan Chi.
PLoS Genet, 2008 Dec 06; 4(12). PMID: 19057672    Free PMC article.
Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast.
Maike Sonnenberg, Heiko van der Kuip, +6 authors, Walter E Aulitzky.
BMC Cancer, 2008 Dec 17; 8. PMID: 19077243    Free PMC article.
Statistical issues and analyses of in vivo and in vitro genomic data in order to identify clinically relevant profiles.
Laila M Poisson, Debashis Ghosh.
Cancer Inform, 2007 Jan 01; 3. PMID: 19079768    Free PMC article.
Toll-like receptors, wound healing, and carcinogenesis.
Johannes Kluwe, Ali Mencin, Robert F Schwabe.
J Mol Med (Berl), 2008 Dec 18; 87(2). PMID: 19089397    Free PMC article.
Mechanisms of metastasis.
Kent W Hunter, Nigel P S Crawford, Jude Alsarraj.
Breast Cancer Res, 2009 Jan 06; 10 Suppl 1. PMID: 19091006    Free PMC article.
Breast cancer by proxy: can the microenvironment be both the cause and consequence?
Lone Rønnov-Jessen, Mina J Bissell.
Trends Mol Med, 2008 Dec 19; 15(1). PMID: 19091631    Free PMC article.
Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis.
Zhong Wu, HyungJun Cho, Garret M Hampton, Dan Theodorescu.
Neoplasia, 2008 Dec 25; 11(1). PMID: 19107233    Free PMC article.
Mesenchymal stem cells: the fibroblasts' new clothes?
Muzlifah A Haniffa, Matthew P Collin, Christopher D Buckley, Francesco Dazzi.
Haematologica, 2008 Dec 26; 94(2). PMID: 19109217    Free PMC article.
Highly Cited. Review.
Molecular basis of metastasis.
Anne C Chiang, Joan Massagué.
N Engl J Med, 2008 Dec 26; 359(26). PMID: 19109576    Free PMC article.
Highly Cited. Review.
Seed in soil, with an epigenetic view.
Huey-Jen L Lin, Tao Zuo, +4 authors, Tim H-M Huang.
Biochim Biophys Acta, 2009 Jan 24; 1790(9). PMID: 19162126    Free PMC article.
Dynamic modularity in protein interaction networks predicts breast cancer outcome.
Ian W Taylor, Rune Linding, +7 authors, Jeffrey L Wrana.
Nat Biotechnol, 2009 Feb 03; 27(2). PMID: 19182785
Highly Cited.
[Genome-wide expression profiling as a clinical tool: are we there yet?].
F C Geyer, T Decker, J S Reis-Filho.
Pathologe, 2009 Feb 17; 30(2). PMID: 19219435
Biological convergence of cancer signatures.
Xavier Solé, Núria Bonifaci, +11 authors, Miguel Angel Pujana.
PLoS One, 2009 Feb 21; 4(2). PMID: 19229342    Free PMC article.
Correlation signature of the macroscopic states of the gene regulatory network in cancer.
Nikolai Slavov, Kenneth A Dawson.
Proc Natl Acad Sci U S A, 2009 Feb 28; 106(11). PMID: 19246374    Free PMC article.
Non-negative matrix factorization for the analysis of complex gene expression data: identification of clinically relevant tumor subtypes.
Attila Frigyesi, Mattias Höglund.
Cancer Inform, 2008 Jan 01; 6. PMID: 19259414    Free PMC article.
A radiation-derived gene expression signature predicts clinical outcome for breast cancer patients.
Brian D Piening, Pei Wang, Aravind Subramanian, Amanda G Paulovich.
Radiat Res, 2009 Mar 10; 171(2). PMID: 19267539    Free PMC article.
Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data.
Louis Tong, Jaime Chew, +3 authors, Roger W Beuerman.
BMC Med Genomics, 2009 Mar 11; 2. PMID: 19272163    Free PMC article.
Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells.
Marta Santisteban, Jennifer M Reiman, +10 authors, Keith L Knutson.
Cancer Res, 2009 Mar 12; 69(7). PMID: 19276366    Free PMC article.
Highly Cited.
MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment.
Sean P Pitroda, Nikolai N Khodarev, +2 authors, Ralph R Weichselbaum.
Proc Natl Acad Sci U S A, 2009 Mar 18; 106(14). PMID: 19289846    Free PMC article.
A compact VEGF signature associated with distant metastases and poor outcomes.
Zhiyuan Hu, Cheng Fan, +10 authors, Charles M Perou.
BMC Med, 2009 Mar 18; 7. PMID: 19291283    Free PMC article.
Comparative expression pathway analysis of human and canine mammary tumors.
Paolo Uva, Luigi Aurisicchio, +13 authors, Emanuele de Rinaldis.
BMC Genomics, 2009 Mar 31; 10. PMID: 19327144    Free PMC article.
Breaking down barriers: the importance of the stromal microenvironment in acquiring invasiveness in young women's breast cancer.
Pepper Schedin, Virginia Borges.
Breast Cancer Res, 2009 Apr 07; 11(2). PMID: 19344495    Free PMC article.
Gene expression profiles and breast cancer metastasis: a genetic perspective.
Kent W Hunter, Jude Alsarraj.
Clin Exp Metastasis, 2009 Apr 07; 26(6). PMID: 19347591    Free PMC article.
Cancer micrometastases.
Klaus Pantel, Catherine Alix-Panabières, Sabine Riethdorf.
Nat Rev Clin Oncol, 2009 Apr 29; 6(6). PMID: 19399023
Highly Cited. Review.
Identification of differentially expressed subnetworks based on multivariate ANOVA.
Taeyoung Hwang, Taesung Park.
BMC Bioinformatics, 2009 May 02; 10. PMID: 19405941    Free PMC article.
A mouse mammary gland involution mRNA signature identifies biological pathways potentially associated with breast cancer metastasis.
Torsten Stein, Nathan Salomonis, +2 authors, Barry A Gusterson.
J Mammary Gland Biol Neoplasia, 2009 May 02; 14(2). PMID: 19408105
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.
Yadi Wu, Jiong Deng, +3 authors, Binhua P Zhou.
Cancer Cell, 2009 May 05; 15(5). PMID: 19411070    Free PMC article.
Highly Cited.
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers.
Agnieszka K Witkiewicz, Abhijit Dasgupta, +6 authors, Michael P Lisanti.
Am J Pathol, 2009 May 05; 174(6). PMID: 19411448    Free PMC article.
Highly Cited.
Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities.
Valsala Haridas, Goshi Nishimura, +5 authors, Jordan U Gutterman.
PLoS One, 2009 May 15; 4(5). PMID: 19440292    Free PMC article.
Global gene expression analysis of reactive stroma in prostate cancer.
Olga Dakhova, Mustafa Ozen, +4 authors, Michael Ittmann.
Clin Cancer Res, 2009 Jun 11; 15(12). PMID: 19509179    Free PMC article.
Alteration of gene expression signatures of cortical differentiation and wound response in lethal clear cell renal cell carcinomas.
Hongjuan Zhao, Zongming Ma, +3 authors, James D Brooks.
PLoS One, 2009 Jun 27; 4(6). PMID: 19557179    Free PMC article.
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
Jessica Kao, Keyan Salari, +9 authors, Jonathan R Pollack.
PLoS One, 2009 Jul 08; 4(7). PMID: 19582160    Free PMC article.
Highly Cited.
Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma.
Ariel Anguiano, Sascha A Tuchman, +8 authors, Anil Potti.
J Clin Oncol, 2009 Jul 29; 27(25). PMID: 19636021    Free PMC article.
Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling.
Julie M Kneller, Thomas Ehlen, +8 authors, Steven J M Jones.
Biomark Insights, 2007 Jan 01; 2. PMID: 19662225    Free PMC article.
A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response.
Sanjay Chandriani, Eirik Frengen, +4 authors, Michael D Cole.
PLoS One, 2009 Aug 20; 4(8). PMID: 19690609    Free PMC article.
Confounding effects in "A six-gene signature predicting breast cancer lung metastasis".
Aedín C Culhane, John Quackenbush.
Cancer Res, 2009 Sep 03; 69(18). PMID: 19723662    Free PMC article.
Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells.
Shanaz H Dairkee, Aejaz Sayeed, +6 authors, Dan H Moore.
Cancer Res, 2009 Oct 01; 69(19). PMID: 19789341    Free PMC article.
Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer.
Martin Buess, Michal Rajski, +2 authors, Christoph Rochlitz.
Neoplasia, 2009 Oct 02; 11(10). PMID: 19794958    Free PMC article.
Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.
Astrid Rohrbeck, Jürgen Borlak.
PLoS One, 2009 Oct 09; 4(10). PMID: 19812696    Free PMC article.
Activation of host wound responses in breast cancer microenvironment.
Melissa A Troester, Myung Hee Lee, +7 authors, Sallie Smith Schneider.
Clin Cancer Res, 2009 Nov 06; 15(22). PMID: 19887484    Free PMC article.
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.
J Joshua Smith, Natasha G Deane, +16 authors, R Daniel Beauchamp.
Gastroenterology, 2009 Nov 17; 138(3). PMID: 19914252    Free PMC article.
Highly Cited.
Impact of biospecimens handling on biomarker research in breast cancer.
Loris De Cecco, Valeria Musella, +6 authors, Maria Grazia Daidone.
BMC Cancer, 2009 Nov 26; 9. PMID: 19930681    Free PMC article.
Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ.
M Sharma, A H Beck, +6 authors, R B West.
Breast Cancer Res Treat, 2009 Dec 02; 123(2). PMID: 19949854    Free PMC article.
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.
Nancy Dumont, Yongping G Crawford, +9 authors, Thea D Tlsty.
Breast Cancer Res, 2009 Dec 10; 11(6). PMID: 19995452    Free PMC article.
Transcriptional response in the peripheral blood of patients infected with Salmonella enterica serovar Typhi.
Lucinda J Thompson, Sarah J Dunstan, +14 authors, Stanley Falkow.
Proc Natl Acad Sci U S A, 2009 Dec 19; 106(52). PMID: 20018727    Free PMC article.
Breast tumour stroma is a prognostic indicator and target for therapy.
Anthony Howell, Goran Landberg, Jonas Bergh.
Breast Cancer Res, 2010 Jan 20; 11 Suppl 3. PMID: 20030867    Free PMC article.
Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells.
Nathan J Bowen, L DeEtte Walker, +4 authors, John F McDonald.
BMC Med Genomics, 2009 Dec 31; 2. PMID: 20040092    Free PMC article.
IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.
Michal Rajski, Rosanna Zanetti-Dällenbach, +3 authors, Martin Buess.
BMC Med, 2010 Jan 07; 8. PMID: 20051100    Free PMC article.
Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets.
Esteban Czwan, Benedikt Brors, David Kipling.
BMC Bioinformatics, 2010 Jan 13; 11. PMID: 20064243    Free PMC article.
The role of stromal factors in breast tumorigenicity.
Danh Tran-Thanh, Susan J Done.
Am J Pathol, 2010 Jan 23; 176(3). PMID: 20093480    Free PMC article.
Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.
Daniel P Silver, Andrea L Richardson, +19 authors, Judy E Garber.
J Clin Oncol, 2010 Jan 27; 28(7). PMID: 20100965    Free PMC article.
Highly Cited.
MYC regulation of a "poor-prognosis" metastatic cancer cell state.
Anita Wolfer, Ben S Wittner, +14 authors, Sridhar Ramaswamy.
Proc Natl Acad Sci U S A, 2010 Feb 06; 107(8). PMID: 20133671    Free PMC article.
LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer.
Yoon-La Choi, Melanie Bocanegra, +6 authors, Jonathan R Pollack.
Cancer Res, 2010 Mar 11; 70(6). PMID: 20215510    Free PMC article.
Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth.
Dalit Barkan, Jeffrey E Green, Ann F Chambers.
Eur J Cancer, 2010 Mar 23; 46(7). PMID: 20304630    Free PMC article.
Highly Cited. Review.
Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression.
Anke H Sillars-Hardebol, Beatriz Carvalho, +7 authors, Remond J A Fijneman.
Tumour Biol, 2010 Apr 02; 31(2). PMID: 20358421    Free PMC article.
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer.
Kate Lawrenson, Barbara Grun, +3 authors, Simon A Gayther.
Neoplasia, 2010 Apr 03; 12(4). PMID: 20360942    Free PMC article.
Formalin-induced fluorescence reveals cell shape and morphology in biological tissue samples.
Ulrich Leischner, Anja Schierloh, Walter Zieglgänsberger, Hans-Ulrich Dodt.
PLoS One, 2010 May 04; 5(4). PMID: 20436930    Free PMC article.
Heterogeneity of the tumor vasculature.
Janice A Nagy, Sung-Hee Chang, +2 authors, Harold F Dvorak.
Semin Thromb Hemost, 2010 May 22; 36(3). PMID: 20490982    Free PMC article.
Highly Cited. Review.
Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes.
Francesca Orso, Davide Corà, +3 authors, Daniela Taverna.
BMC Genomics, 2010 Jun 08; 11. PMID: 20525283    Free PMC article.
Oxidative stress promotes myofibroblast differentiation and tumour spreading.
Aurore Toullec, Damien Gerald, +14 authors, Fatima Mechta-Grigoriou.
EMBO Mol Med, 2010 Jun 11; 2(6). PMID: 20535745    Free PMC article.
Highly Cited.
Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts.
Silke Haubeiss, Jens O Schmid, +4 authors, Walter E Aulitzky.
Mol Cancer, 2010 Jun 29; 9. PMID: 20579391    Free PMC article.
The role of the microenvironment in mammary gland development and cancer.
Kornelia Polyak, Raghu Kalluri.
Cold Spring Harb Perspect Biol, 2010 Jul 02; 2(11). PMID: 20591988    Free PMC article.
Highly Cited. Review.
Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation.
Corey S Frucht, Mohamed Uduman, +3 authors, Dhasakumar S Navaratnam.
PLoS One, 2010 Jul 17; 5(7). PMID: 20634979    Free PMC article.
Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer.
Aslaug Aamodt Muggerud, Michael Hallett, +8 authors, Fredrik Wärnberg.
Mol Oncol, 2010 Jul 29; 4(4). PMID: 20663721    Free PMC article.
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.
Guillaume Banneau, Mickaël Guedj, +15 authors, Michel Longy.
Breast Cancer Res, 2010 Aug 18; 12(4). PMID: 20712882    Free PMC article.
Enumerating the gene sets in breast cancer, a "direct" alternative to hierarchical clustering.
Dwain Mefford, Joel A Mefford.
BMC Genomics, 2010 Aug 25; 11. PMID: 20731868    Free PMC article.
Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers.
Joseph E Lucas, Hsiu-Ni Kung, Jen-Tsan A Chi.
PLoS Comput Biol, 2010 Sep 09; 6(9). PMID: 20824128    Free PMC article.
Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.
Julia Ling-Yu Chen, Daniel Merl, +7 authors, Jen-Tsan Chi.
PLoS Genet, 2010 Sep 17; 6(9). PMID: 20844768    Free PMC article.
Breast cancer in the personal genomics era.
Rachel E Ellsworth, David J Decewicz, Craig D Shriver, Darrell L Ellsworth.
Curr Genomics, 2010 Nov 03; 11(3). PMID: 21037853    Free PMC article.
Systems biology and genomics of breast cancer.
Charles M Perou, Anne-Lise Børresen-Dale.
Cold Spring Harb Perspect Biol, 2010 Nov 05; 3(2). PMID: 21047916    Free PMC article.
Adjuvant Systemic Therapy, Quo Vadis? Patient Selection, Prognostic and Predictive Factors.
Fatima Cardoso.
Breast Care (Basel), 2008 Jan 01; 3(6). PMID: 21048908    Free PMC article.
Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in response to serum starvation/replenishment.
Ceren Sucularli, Serif Senturk, Mehmet Ozturk, Ozlen Konu.
Mol Biol Rep, 2010 Dec 01; 38(6). PMID: 21116857
Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis.
Salomé González-Reyes, Laura Marín, +5 authors, Francisco J Vizoso.
BMC Cancer, 2010 Dec 07; 10. PMID: 21129170    Free PMC article.
Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX Colon Cancer Assay.
Kim M Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar, Drew Watson.
BMC Cancer, 2010 Dec 24; 10. PMID: 21176237    Free PMC article.
TAK1 regulates SCF expression to modulate PKBα activity that protects keratinocytes from ROS-induced apoptosis.
C R I Lam, M J Tan, +3 authors, N S Tan.
Cell Death Differ, 2011 Jan 15; 18(7). PMID: 21233843    Free PMC article.
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.
Moshe Elkabets, Ann M Gifford, +10 authors, Sandra S McAllister.
J Clin Invest, 2011 Jan 27; 121(2). PMID: 21266779    Free PMC article.
Highly Cited.
Gene expression patterns related to vascular invasion and aggressive features in endometrial cancer.
Monica Mannelqvist, Ingunn M Stefansson, +6 authors, Lars A Akslen.
Am J Pathol, 2011 Feb 02; 178(2). PMID: 21281818    Free PMC article.
Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer.
Stefan Ambs, Sharon A Glynn.
Cell Cycle, 2011 Feb 05; 10(4). PMID: 21293193    Free PMC article.
Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue.
Lorenza Mittempergher, Jorma J de Ronde, +5 authors, Laura J Van't Veer.
PLoS One, 2011 Feb 25; 6(2). PMID: 21347257    Free PMC article.
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression.
Mina J Bissell, William C Hines.
Nat Med, 2011 Mar 09; 17(3). PMID: 21383745    Free PMC article.
Highly Cited. Review.
A signature inferred from Drosophila mitotic genes predicts survival of breast cancer patients.
Christian Damasco, Antonio Lembo, +3 authors, Paolo Provero.
PLoS One, 2011 Mar 10; 6(2). PMID: 21386884    Free PMC article.
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.
Kevin C Wang, Yul W Yang, +12 authors, Howard Y Chang.
Nature, 2011 Mar 23; 472(7341). PMID: 21423168    Free PMC article.
Highly Cited.
Do two machine-learning based prognostic signatures for breast cancer capture the same biological processes?
Yotam Drier, Eytan Domany.
PLoS One, 2011 Mar 23; 6(3). PMID: 21423753    Free PMC article.
Combining gene signatures improves prediction of breast cancer survival.
Xi Zhao, Einar Andreas Rødland, +6 authors, Ole Christian Lingjærde.
PLoS One, 2011 Mar 23; 6(3). PMID: 21423775    Free PMC article.
GOBO: gene expression-based outcome for breast cancer online.
Markus Ringnér, Erik Fredlund, +2 authors, Johan Staaf.
PLoS One, 2011 Mar 30; 6(3). PMID: 21445301    Free PMC article.
Highly Cited.
Signaling pathways in breast cancer metastasis - novel insights from functional genomics.
Mario Andres Blanco, Yibin Kang.
Breast Cancer Res, 2011 Apr 05; 13(2). PMID: 21457525    Free PMC article.
Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer.
Anne Planche, Marina Bacac, +4 authors, Ivan Stamenkovic.
PLoS One, 2011 May 26; 6(5). PMID: 21611158    Free PMC article.
Large-scale analysis of expression signatures reveals hidden links among diverse cellular processes.
Steven X Ge.
BMC Syst Biol, 2011 May 31; 5. PMID: 21619705    Free PMC article.
18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Nicolaos Palaskas, Steven M Larson, +20 authors, Ingo K Mellinghoff.
Cancer Res, 2011 Jun 08; 71(15). PMID: 21646475    Free PMC article.
The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy.
Mauro Savino, Daniela Annibali, +5 authors, Sergio Nasi.
PLoS One, 2011 Aug 04; 6(7). PMID: 21811581    Free PMC article.
Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts.
D Perna, G Fagà, +13 authors, B Amati.
Oncogene, 2011 Aug 24; 31(13). PMID: 21860422    Free PMC article.
The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation.
Andrew C Newman, Martin N Nakatsu, +2 authors, Christopher C W Hughes.
Mol Biol Cell, 2011 Aug 26; 22(20). PMID: 21865599    Free PMC article.
Highly Cited.
A new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis.
Dong-Yu Wang, Susan J Done, +3 authors, Wey Liang Leong.
Breast Cancer Res, 2011 Sep 24; 13(5). PMID: 21939527    Free PMC article.
Lessons from a decade of integrating cancer copy number alterations with gene expression profiles.
Norman Huang, Parantu K Shah, Cheng Li.
Brief Bioinform, 2011 Sep 29; 13(3). PMID: 21949216    Free PMC article.
Tumor metastasis: molecular insights and evolving paradigms.
Scott Valastyan, Robert A Weinberg.
Cell, 2011 Oct 18; 147(2). PMID: 22000009    Free PMC article.
Highly Cited. Review.
Most random gene expression signatures are significantly associated with breast cancer outcome.
David Venet, Jacques E Dumont, Vincent Detours.
PLoS Comput Biol, 2011 Oct 27; 7(10). PMID: 22028643    Free PMC article.
Highly Cited.
Stanniocalcin-1 regulates re-epithelialization in human keratinocytes.
Bonnie H Y Yeung, Chris K C Wong.
PLoS One, 2011 Nov 10; 6(11). PMID: 22069492    Free PMC article.
The microenvironment in breast cancer progression: biology and implications for treatment.
Andrew E Place, Sung Jin Huh, Kornelia Polyak.
Breast Cancer Res, 2011 Nov 15; 13(6). PMID: 22078026    Free PMC article.
Highly Cited. Review.
Basal breast cancer: a complex and deadly molecular subtype.
F Bertucci, P Finetti, D Birnbaum.
Curr Mol Med, 2011 Nov 16; 12(1). PMID: 22082486    Free PMC article.
Invasive Breast Cancer: Recognition of Molecular Subtypes.
Johanna D Strehl, David L Wachter, +2 authors, Arndt Hartmann.
Breast Care (Basel), 2011 Dec 03; 6(4). PMID: 22135623    Free PMC article.
Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.
Maria Antsiferova, Marcel Huber, +7 authors, Sabine Werner.
Nat Commun, 2011 Dec 08; 2. PMID: 22146395    Free PMC article.
A simple but highly effective approach to evaluate the prognostic performance of gene expression signatures.
Maud H W Starmans, Glenn Fung, +2 authors, Philippe Lambin.
PLoS One, 2011 Dec 14; 6(12). PMID: 22163293    Free PMC article.
Role of tumor associated fibroblasts in human liver regeneration, cirrhosis, and cancer.
Daniela Cesselli, Antonio Paolo Beltrami, +11 authors, Carlo Alberto Beltrami.
Int J Hepatol, 2011 Dec 22; 2011. PMID: 22187657    Free PMC article.
Gene expression analysis of in vitro cocultures to study interactions between breast epithelium and stroma.
Patricia Casbas-Hernandez, Jodie M Fleming, Melissa A Troester.
J Biomed Biotechnol, 2011 Dec 29; 2011. PMID: 22203785    Free PMC article.
Targeting stroma to treat cancers.
Boris Engels, Donald A Rowley, Hans Schreiber.
Semin Cancer Biol, 2012 Jan 04; 22(1). PMID: 22212863    Free PMC article.
'Omic approaches to preventing or managing metastatic breast cancer.
Obi L Griffith, Joe W Gray.
Breast Cancer Res, 2012 Jan 06; 13(6). PMID: 22216753    Free PMC article.
Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures.
Thomas Karn, Lajos Pusztai, +12 authors, Achim Rody.
PLoS One, 2012 Jan 06; 6(12). PMID: 22220191    Free PMC article.
Global gene expression analysis of the interaction between cancer cells and osteoblasts to predict bone metastasis in breast cancer.
Michal Rajski, Brigitte Vogel, +2 authors, Martin Buess.
PLoS One, 2012 Jan 12; 7(1). PMID: 22235336    Free PMC article.
Gene signatures revisited.
Stuart G Baker.
J Natl Cancer Inst, 2012 Jan 21; 104(4). PMID: 22262869    Free PMC article.
Transcriptome and proteome research in veterinary science: what is possible and what questions can be asked?
Robert Klopfleisch, Achim D Gruber.
ScientificWorldJournal, 2012 Jan 21; 2012. PMID: 22262952    Free PMC article.
Primary xenografts of human prostate tissue as a model to study angiogenesis induced by reactive stroma.
Viviana P Montecinos, Alejandro Godoy, +2 authors, Gary J Smith.
PLoS One, 2012 Feb 04; 7(1). PMID: 22303438    Free PMC article.
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
Benjamin T Spike, Dannielle D Engle, +3 authors, Geoffrey M Wahl.
Cell Stem Cell, 2012 Feb 07; 10(2). PMID: 22305568    Free PMC article.
Highly Cited.
Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer.
Hae Kyung Im, Eric R Gamazon, +3 authors, M Eileen Dolan.
PLoS Genet, 2012 Feb 22; 8(2). PMID: 22346769    Free PMC article.
Vascular hyperpermeability, angiogenesis, and stroma generation.
Janice A Nagy, Ann M Dvorak, Harold F Dvorak.
Cold Spring Harb Perspect Med, 2012 Feb 23; 2(2). PMID: 22355795    Free PMC article.
Epithelial stem cells, wound healing and cancer.
Esther N Arwert, Esther Hoste, Fiona M Watt.
Nat Rev Cancer, 2012 Mar 01; 12(3). PMID: 22362215
Highly Cited. Review.
A prognostic gene expression profile that predicts circulating tumor cell presence in breast cancer patients.
Timothy J Molloy, Paul Roepman, Bjørn Naume, Laura J van't Veer.
PLoS One, 2012 Mar 03; 7(2). PMID: 22384245    Free PMC article.
Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients.
Erick Román-Pérez, Patricia Casbas-Hernández, +6 authors, Melissa A Troester.
Breast Cancer Res, 2012 Mar 21; 14(2). PMID: 22429463    Free PMC article.
The prognostic significance of tumor-associated stroma in invasive breast carcinoma.
Soomin Ahn, Junhun Cho, +4 authors, Eun Yoon Cho.
Tumour Biol, 2012 May 15; 33(5). PMID: 22581521
Identifying gnostic predictors of the vaccine response.
W Nicholas Haining, Bali Pulendran.
Curr Opin Immunol, 2012 May 29; 24(3). PMID: 22633886    Free PMC article.
Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression.
M A López-Lago, S Posner, +3 authors, R S K Chaganti.
Oncogene, 2012 Jun 06; 32(14). PMID: 22665059    Free PMC article.
Wnt signaling and injury repair.
Jemima L Whyte, Andrew A Smith, Jill A Helms.
Cold Spring Harb Perspect Biol, 2012 Jun 23; 4(8). PMID: 22723493    Free PMC article.
Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control.
Gavin D Grant, Joshua Gamsby, +6 authors, Michael L Whitfield.
Mol Biol Cell, 2012 Jun 29; 23(16). PMID: 22740631    Free PMC article.
Exploring molecular links between lymph node invasion and cancer prognosis in human breast cancer.
Sangwoo Kim, Hojung Nam, Doheon Lee.
BMC Syst Biol, 2012 Jul 20; 5 Suppl 2. PMID: 22784575    Free PMC article.
Expression of the E-cadherin repressors Snail, Slug and Zeb1 in urothelial carcinoma of the urinary bladder: relation to stromal fibroblast activation and invasive behaviour of carcinoma cells.
Julia Schulte, Michaela Weidig, +9 authors, Alexander Berndt.
Histochem Cell Biol, 2012 Jul 24; 138(6). PMID: 22820858
An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity.
Aaron Boudreau, Laura J van't Veer, Mina J Bissell.
Cell Adh Migr, 2012 Aug 07; 6(3). PMID: 22863741    Free PMC article.
Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes.
Marta Dueñas, Mirentxu Santos, +13 authors, Ramón García-Escudero.
PLoS One, 2012 Aug 11; 7(8). PMID: 22880004    Free PMC article.
Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes.
François Pepin, Nicholas Bertos, +7 authors, Morag Park.
Breast Cancer Res, 2012 Aug 22; 14(4). PMID: 22906178    Free PMC article.
A sample selection strategy to boost the statistical power of signature detection in cancer expression profile studies.
Zhenyu Jia, Yipeng Wang, +8 authors, Dan Mercola.
Anticancer Agents Med Chem, 2012 Sep 01; 13(2). PMID: 22934703    Free PMC article.
Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2'-deoxycytidine.
Jun Yu, Kimberly Walter, +5 authors, Michael Goggins.
PLoS One, 2012 Sep 18; 7(9). PMID: 22984426    Free PMC article.
Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows.
Cathriona Foley, Aspinas Chapwanya, +7 authors, Kieran G Meade.
BMC Genomics, 2012 Sep 19; 13. PMID: 22985206    Free PMC article.
Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility.
Antoine M Snijders, Francesco Marchetti, +6 authors, Andrew J Wyrobek.
PLoS One, 2012 Oct 19; 7(10). PMID: 23077491    Free PMC article.
Transcription factor networks in invasion-promoting breast carcinoma-associated fibroblasts.
A Siletz, E Kniazeva, J S Jeruss, L D Shea.
Cancer Microenviron, 2012 Oct 24; 6(1). PMID: 23090154    Free PMC article.
Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.
Antonia Patsialou, Yarong Wang, +4 authors, John S Condeelis.
Breast Cancer Res, 2012 Nov 02; 14(5). PMID: 23113900    Free PMC article.
Tryptase-positive mast cells and angiogenesis in keloids: a new possible post-surgical target for prevention.
Michele Ammendola, Valeria Zuccalà, +9 authors, Girolamo Ranieri.
Updates Surg, 2012 Nov 03; 65(1). PMID: 23117746
Fibroblasts as architects of cancer pathogenesis.
Timothy Marsh, Kristian Pietras, Sandra S McAllister.
Biochim Biophys Acta, 2012 Nov 06; 1832(7). PMID: 23123598    Free PMC article.
Highly Cited. Review.
Somatic evolution of head and neck cancer - biological robustness and latent vulnerability.
Muneyuki Masuda, Satoshi Toh, +2 authors, Andrew K Joe.
Mol Oncol, 2012 Nov 22; 7(1). PMID: 23168041    Free PMC article.
Prediction and prognosis: impact of gene expression profiling in personalized treatment of breast cancer patients.
Michael R Mallmann, Andrea Staratschek-Jox, +5 authors, Joachim L Schultze.
EPMA J, 2010 Sep 01; 1(3). PMID: 23199086    Free PMC article.
Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.
Chi-Rong Li, Jimmy J-M Su, +10 authors, Kelvin K-C Tsai.
Am J Pathol, 2012 Dec 12; 182(2). PMID: 23219426    Free PMC article.
Clinical and multiple gene expression variables in survival analysis of breast cancer: analysis with the hypertabastic survival model.
Mohammad A Tabatabai, Wayne M Eby, +2 authors, Karan P Singh.
BMC Med Genomics, 2012 Dec 18; 5. PMID: 23241496    Free PMC article.
A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes.
Damon Polioudakis, Akshay A Bhinge, +3 authors, Vishwanath R Iyer.
Nucleic Acids Res, 2013 Jan 11; 41(4). PMID: 23303785    Free PMC article.
Prediction of breast cancer metastasis by gene expression profiles: a comparison of metagenes and single genes.
Mark Burton, Mads Thomassen, Qihua Tan, Torben A Kruse.
Cancer Inform, 2013 Jan 11; 11. PMID: 23304070    Free PMC article.
Role of stromal-epithelial interaction in the formation and development of cancer cells.
Viktor Shtilbans.
Cancer Microenviron, 2013 Feb 23; 6(3). PMID: 23430817    Free PMC article.
Emerging targeted agents in metastatic breast cancer.
Dimitrios Zardavas, José Baselga, Martine Piccart.
Nat Rev Clin Oncol, 2013 Mar 06; 10(4). PMID: 23459626
Highly Cited. Review.
Prognostic value of single nucleotide polymorphisms of candidate genes associated with inflammation in early stage breast cancer.
James L Murray, Patricia Thompson, +7 authors, Abenaa M Brewster.
Breast Cancer Res Treat, 2013 Mar 27; 138(3). PMID: 23529385    Free PMC article.
Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways.
Margit L H Riis, Xi Zhao, +6 authors, Vessela N Kristensen.
ISRN Oncol, 2013 Mar 28; 2013. PMID: 23533813    Free PMC article.
Integrins and metastasis.
Kirat Kumar Ganguly, Sekhar Pal, Shuvojit Moulik, Amitava Chatterjee.
Cell Adh Migr, 2013 Apr 09; 7(3). PMID: 23563505    Free PMC article.
Dynamic transcription factor networks in epithelial-mesenchymal transition in breast cancer models.
Anaar Siletz, Michael Schnabel, +4 authors, Lonnie D Shea.
PLoS One, 2013 Apr 18; 8(4). PMID: 23593114    Free PMC article.
Transcriptional control of cancer metastasis.
Brian Ell, Yibin Kang.
Trends Cell Biol, 2013 Jul 11; 23(12). PMID: 23838335    Free PMC article.
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma.
Tzu-Hung Hsiao, Hung-I Harry Chen, +5 authors, Yidong Chen.
Transl Cancer Res, 2013 Aug 02; 2(1). PMID: 23905013    Free PMC article.
Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer.
Amy E McCart Reed, Sarah Song, +5 authors, Peter T Simpson.
Virchows Arch, 2013 Aug 15; 463(4). PMID: 23942617
Preliminary evaluation of the wound healing effect of Vitex doniana sweet (Verbenaceae) in mice.
K Amegbor, K Metowogo, +4 authors, M Gbeassor.
Afr J Tradit Complement Altern Med, 2012 Jan 01; 9(4). PMID: 23983395    Free PMC article.
Tumor-secreted LOXL2 activates fibroblasts through FAK signaling.
Holly E Barker, Demelza Bird, Georgina Lang, Janine T Erler.
Mol Cancer Res, 2013 Sep 07; 11(11). PMID: 24008674    Free PMC article.
Understanding the tumor microenvironment and radioresistance by combining functional imaging with global gene expression.
Mark W Dewhirst, Jen-Tsan Chi.
Semin Radiat Oncol, 2013 Sep 10; 23(4). PMID: 24012344    Free PMC article.
Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.
Sandro Goruppi, G Paolo Dotto.
Trends Cell Biol, 2013 Oct 01; 23(12). PMID: 24074947    Free PMC article.
Breast tumors with elevated expression of 1q candidate genes confer poor clinical outcome and sensitivity to Ras/PI3K inhibition.
Muthulakshmi Muthuswami, Vignesh Ramesh, +6 authors, Kumaresan Ganesan.
PLoS One, 2013 Oct 23; 8(10). PMID: 24147022    Free PMC article.
A novel rapid-onset high-penetrance plasmacytoma mouse model driven by deregulation of cMYC cooperating with KRAS12V in BALB/c mice.
Y Hu, M Zheng, +5 authors, K C Anderson.
Blood Cancer J, 2013 Nov 05; 3. PMID: 24185503    Free PMC article.
Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer.
Alexandra Montagner, Maria B Delgado, +15 authors, Walter Wahli.
EMBO Mol Med, 2013 Nov 10; 6(1). PMID: 24203162    Free PMC article.
Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases.
Dongwei Gao, Sha Li.
Cancer Microenviron, 2013 Nov 12; 6(3). PMID: 24214411    Free PMC article.
Wound Healing Versus Regeneration: Role of the Tissue Environment in Regenerative Medicine.
Anthony Atala, Darrell J Irvine, Marsha Moses, Sunil Shaunak.
MRS Bull, 2010 Aug 01; 35(8). PMID: 24241586    Free PMC article.
Surgery triggers outgrowth of latent distant disease in breast cancer: an inconvenient truth?
Michael Retsky, Romano Demicheli, +2 authors, Isaac Gukas.
Cancers (Basel), 2010 Jan 01; 2(2). PMID: 24281072    Free PMC article.
Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival.
F Bertucci, N T Ueno, +16 authors, S J Van Laere.
Ann Oncol, 2013 Dec 05; 25(2). PMID: 24299959    Free PMC article.
Next generation sequencing-based expression profiling identifies signatures from benign stromal proliferations that define stromal components of breast cancer.
Xiangqian Guo, Shirley X Zhu, +2 authors, Robert B West.
Breast Cancer Res, 2013 Dec 18; 15(6). PMID: 24342436    Free PMC article.
Breast tumor PDXs are genetically plastic and correspond to a subset of aggressive cancers prone to relapse.
Stanislas du Manoir, Béatrice Orsetti, +8 authors, Charles Theillet.
Mol Oncol, 2014 Jan 08; 8(2). PMID: 24394560    Free PMC article.
Boosting the concordance index for survival data--a unified framework to derive and evaluate biomarker combinations.
Andreas Mayr, Matthias Schmid.
PLoS One, 2014 Jan 09; 9(1). PMID: 24400093    Free PMC article.
Regularized Multivariate Regression for Identifying Master Predictors with Application to Integrative Genomics Study of Breast Cancer.
Jie Peng, Ji Zhu, +4 authors, Pei Wang.
Ann Appl Stat, 2010 Mar 01; 4(1). PMID: 24489618    Free PMC article.
Translational Bioinformatics Approaches to Drug Development.
Ben Readhead, Joel Dudley.
Adv Wound Care (New Rochelle), 2014 Feb 15; 2(9). PMID: 24527359    Free PMC article.
Annotation enrichment analysis: an alternative method for evaluating the functional properties of gene sets.
Kimberly Glass, Michelle Girvan.
Sci Rep, 2014 Feb 27; 4. PMID: 24569707    Free PMC article.
A core invasiveness gene signature reflects epithelial-to-mesenchymal transition but not metastatic potential in breast cancer cell lines and tissue samples.
Melike Marsan, Gert Van den Eynden, +7 authors, Steven J Van Laere.
PLoS One, 2014 Mar 04; 9(2). PMID: 24586640    Free PMC article.
A personalized committee classification approach to improving prediction of breast cancer metastasis.
Md Jamiul Jahid, Tim H Huang, Jianhua Ruan.
Bioinformatics, 2014 Mar 13; 30(13). PMID: 24618465    Free PMC article.
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
Xi Zhao, Einar Andreas Rødland, +5 authors, Anne-Lise Børresen-Dale.
BMC Cancer, 2014 Mar 22; 14. PMID: 24645668    Free PMC article.
Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment.
Martin Augsten.
Front Oncol, 2014 Apr 16; 4. PMID: 24734219    Free PMC article.
Highly Cited. Review.
Microarray analysis of cell cycle gene expression in adult human corneal endothelial cells.
Binh Minh Ha Thi, Nelly Campolmi, +9 authors, Gilles Thuret.
PLoS One, 2014 Apr 22; 9(4). PMID: 24747418    Free PMC article.
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer.
Michael W Hance, Krystal D Nolan, Jennifer S Isaacs.
Cancers (Basel), 2014 May 09; 6(2). PMID: 24805867    Free PMC article.
Hypoxia and the extracellular matrix: drivers of tumour metastasis.
Daniele M Gilkes, Gregg L Semenza, Denis Wirtz.
Nat Rev Cancer, 2014 May 16; 14(6). PMID: 24827502    Free PMC article.
Highly Cited. Review.
Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information.
Mireia Berdiel-Acer, Rebeca Sanz-Pamplona, +9 authors, David G Molleví.
Mol Oncol, 2014 May 21; 8(7). PMID: 24839936    Free PMC article.
Identification of a transcriptional signature for the wound healing continuum.
Matthew A Peake, Mathew Caley, +6 authors, Phil Stephens.
Wound Repair Regen, 2014 May 23; 22(3). PMID: 24844339    Free PMC article.
The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance.
Gvantsa Kharaishvili, Dana Simkova, +3 authors, Jan Bouchal.
Cancer Cell Int, 2014 Jun 03; 14. PMID: 24883045    Free PMC article.
Systematic pathway enrichment analysis of a genome-wide association study on breast cancer survival reveals an influence of genes involved in cell adhesion and calcium signaling on the patients' clinical outcome.
Andrea Woltmann, Bowang Chen, +11 authors, Asta Försti.
PLoS One, 2014 Jun 03; 9(6). PMID: 24886783    Free PMC article.
An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.
Monica Mannelqvist, Elisabeth Wik, Ingunn M Stefansson, Lars A Akslen.
PLoS One, 2014 Jun 07; 9(6). PMID: 24905342    Free PMC article.
Gene expression identifies heterogeneity of metastatic behavior among high-grade non-translocation associated soft tissue sarcomas.
Keith M Skubitz, Amy P N Skubitz, +4 authors, Frédéric Chibon.
J Transl Med, 2014 Jun 22; 12. PMID: 24950699    Free PMC article.
Validation of the prognostic gene portfolio, ClinicoMolecular Triad Classification, using an independent prospective breast cancer cohort and external patient populations.
Dong-Yu Wang, Susan J Done, David R Mc Cready, Wey L Leong.
Breast Cancer Res, 2014 Jul 06; 16(4). PMID: 24996446    Free PMC article.
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.
Sandra S McAllister, Robert A Weinberg.
Nat Cell Biol, 2014 Aug 02; 16(8). PMID: 25082194    Free PMC article.
Highly Cited. Review.
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.
Ruth Scherz-Shouval, Sandro Santagata, +8 authors, Susan Lindquist.
Cell, 2014 Aug 02; 158(3). PMID: 25083868    Free PMC article.
Highly Cited.
A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer.
Mireia Berdiel-Acer, Antoni Berenguer, +9 authors, David G Molleví.
Oncotarget, 2014 Aug 15; 5(15). PMID: 25115384    Free PMC article.
The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.
Malgorzata Klauzinska, Nadia P Castro, +5 authors, David Salomon.
Semin Cancer Biol, 2014 Aug 26; 29. PMID: 25153355    Free PMC article.
Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers.
Hang Zhang, Xiyong Liu, +7 authors, Yun Yen.
BMC Cancer, 2014 Sep 13; 14. PMID: 25213022    Free PMC article.
Anomalies in network bridges involved in bile Acid metabolism predict outcomes of colorectal cancer patients.
Sunjae Lee, KiYoung Lee, +2 authors, Doheon Lee.
PLoS One, 2014 Sep 27; 9(9). PMID: 25259881    Free PMC article.
Live fibroblast harvest reveals surface marker shift in vitro.
Graham G Walmsley, Yuval Rinkevich, +11 authors, Michael T Longaker.
Tissue Eng Part C Methods, 2014 Oct 03; 21(3). PMID: 25275778    Free PMC article.
RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response.
Sarah E Brennan-Laun, Xiao-Ling Li, +4 authors, Bret A Hassel.
J Biol Chem, 2014 Oct 11; 289(48). PMID: 25301952    Free PMC article.
[Parallels between wound healing, chronic inflammatory skin diseases and neoplasia: clinical aspects].
A Brown, I Tantcheva-Poor, S A Eming.
Hautarzt, 2014 Oct 17; 65(11). PMID: 25318704
The war on cancer: lessons from the war on terror.
Sui Huang.
Front Oncol, 2014 Nov 05; 4. PMID: 25368844    Free PMC article.
Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations.
A S Abhilash, Brendon M Baker, +2 authors, Vivek B Shenoy.
Biophys J, 2014 Nov 25; 107(8). PMID: 25418164    Free PMC article.
Tumor intrinsic subtype is reflected in cancer-adjacent tissue.
Patricia Casbas-Hernandez, Xuezheng Sun, +9 authors, Melissa A Troester.
Cancer Epidemiol Biomarkers Prev, 2014 Dec 04; 24(2). PMID: 25465802    Free PMC article.
Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases.
Andreia L Bates, Michael W Pickup, +3 authors, Barbara Fingleton.
J Pathol, 2014 Dec 04; 235(5). PMID: 25469981    Free PMC article.
The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches.
Berna C Özdemir, Janine Hensel, +11 authors, Marco G Cecchini.
PLoS One, 2014 Dec 09; 9(12). PMID: 25485970    Free PMC article.
Colorectal Cancer-Associated Fibroblasts are Genotypically Distinct.
Amy A Mrazek, Joseph R Carmical, +4 authors, Celia Chao.
Curr Cancer Ther Rev, 2014 Dec 23; 10(2). PMID: 25530743    Free PMC article.
Tumors: wounds that do not heal-redux.
Harold F Dvorak.
Cancer Immunol Res, 2015 Jan 09; 3(1). PMID: 25568067    Free PMC article.
Highly Cited. Review.
Postoperative electron beam radiotherapy for keloids: treatment outcome and factors associated with occurrence and recurrence.
Sun Young Lee, Jin Park.
Ann Dermatol, 2015 Feb 13; 27(1). PMID: 25673932    Free PMC article.
Stromal transcriptional profiles reveal hierarchies of anatomical site, serum response and disease and identify disease specific pathways.
Andrew Filer, Philipp Antczak, +8 authors, Francesco Falciani.
PLoS One, 2015 Mar 26; 10(3). PMID: 25807374    Free PMC article.
Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer.
Ingunn M Stefansson, Maria Raeder, +10 authors, Lars A Akslen.
Oncotarget, 2015 Apr 11; 6(12). PMID: 25860936    Free PMC article.
A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer.
Abdel Nasser Hosein, Julie Livingstone, +3 authors, Mark Basik.
BMC Cancer, 2015 Apr 18; 15. PMID: 25884794    Free PMC article.
Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value.
Brian David Lehmann, Yan Ding, +6 authors, Yajun Yi.
BMC Cancer, 2015 Apr 18; 15. PMID: 25886164    Free PMC article.
The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer.
Zhihua Li, Xiaohui Zhao, +15 authors, Rufu Chen.
J Transl Med, 2015 Apr 19; 13. PMID: 25889214    Free PMC article.
Highly Cited.
[Tumour-stroma interactions in urothelial cancer].
J Hatina, M Kripnerová, +15 authors, K-H Friedrich.
Urologe A, 2015 Apr 22; 54(4). PMID: 25895564
Clinical management of breast cancer heterogeneity.
Dimitrios Zardavas, Alexandre Irrthum, Charles Swanton, Martine Piccart.
Nat Rev Clin Oncol, 2015 Apr 22; 12(7). PMID: 25895611
Highly Cited. Review.
BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas.
Michal Rajski, Annika Saaf, Martin Buess.
BMC Med Genomics, 2015 May 01; 8. PMID: 25924783    Free PMC article.
MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes.
Damon Polioudakis, Nathan S Abell, Vishwanath R Iyer.
PLoS One, 2015 May 21; 10(5). PMID: 25992613    Free PMC article.
Inflammation fuels tumor progress and metastasis.
Jingyi Liu, Pengnian Charles Lin, Binhua P Zhou.
Curr Pharm Des, 2015 May 26; 21(21). PMID: 26004407    Free PMC article.
Functional organization of the human 4D Nucleome.
Haiming Chen, Jie Chen, +6 authors, Indika Rajapakse.
Proc Natl Acad Sci U S A, 2015 Jun 17; 112(26). PMID: 26080430    Free PMC article.
Assessment of elasticity of colorectal cancer tissue, clinical utility, pathological and phenotypical relevance.
Shingo Kawano, Motohiro Kojima, +7 authors, Norio Saito.
Cancer Sci, 2015 Jun 18; 106(9). PMID: 26083008    Free PMC article.
The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer.
Nicole Antonio, Marie Louise Bønnelykke-Behrndtz, +6 authors, Paul Martin.
EMBO J, 2015 Jul 03; 34(17). PMID: 26136213    Free PMC article.
Highly Cited.
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.
Yu-Pan Bai, Kun Shang, +6 authors, Ying-Yi Li.
Cancer Sci, 2015 Jul 18; 106(10). PMID: 26183471    Free PMC article.
Genetic instability in the tumor microenvironment: a new look at an old neighbor.
Antonio Palumbo, Nathalia de Oliveira Meireles Da Costa, +2 authors, Luiz Eurico Nasciutti.
Mol Cancer, 2015 Aug 01; 14. PMID: 26227631    Free PMC article.
Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis.
Zhanwei Wang, Dionyssios Katsaros, +7 authors, Herbert Yu.
PLoS One, 2015 Aug 20; 10(8). PMID: 26287798    Free PMC article.
IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma.
Amy L Myers, Lin Lin, +8 authors, Andrew C Chang.
Oncotarget, 2015 Sep 01; 6(28). PMID: 26317790    Free PMC article.
Immunity, inflammation, and cancer: an eternal fight between good and evil.
Shabnam Shalapour, Michael Karin.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325032    Free PMC article.
Highly Cited. Review.
Breast Cancer Cell Line Aggregate Morphology Does Not Predict Invasive Capacity.
Michelle J Ziperstein, Asja Guzman, Laura J Kaufman.
PLoS One, 2015 Sep 30; 10(9). PMID: 26418047    Free PMC article.
Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses.
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Oncotarget, 2015 Oct 21; 6(37). PMID: 26485755    Free PMC article.
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