Journal Article
. 2004 Feb; 164(4):370-6.
doi: 10.1001/archinte.164.4.370.

Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies

Mark A Pereira 1 Eilis O'Reilly  Katarina Augustsson  Gary E Fraser  Uri Goldbourt  Berit L Heitmann  Goran Hallmans  Paul Knekt  Simin Liu  Pirjo Pietinen  Donna Spiegelman  June Stevens  Jarmo Virtamo  Walter C Willett  Alberto Ascherio  
Affiliations
  • PMID: 14980987
  •     123 citations

Abstract

Background: Few epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease.

Methods: We analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease.

Results: Over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women.

Conclusion: Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease.

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The cholesterol-lowering effect of unripe Rubus coreanus is associated with decreased oxidized LDL and apolipoprotein B levels in subjects with borderline-high cholesterol levels: a randomized controlled trial.
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J Occup Health, 2020 Jul 28; 62(1). PMID: 32710702    Free PMC article.
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Diabetes Res Clin Pract, 2018 May 18; 141. PMID: 29772288    Free PMC article.
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Gut Microbiota and Type 1 Diabetes Mellitus: The Effect of Mediterranean Diet.
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