Journal Article
. 2004 Mar; 199(6):815-24.
doi: 10.1084/jem.20032220.

In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination

Laura C Bonifaz 1 David P Bonnyay  Anna Charalambous  Dara I Darguste  Shin-Ichiro Fujii  Helena Soares  Marie K Brimnes  Bruno Moltedo  Thomas M Moran  Ralph M Steinman  
Affiliations
  • PMID: 15024047
  •     42 References
  •     375 citations

Abstract

The prevention and treatment of prevalent infectious diseases and tumors should benefit from improvements in the induction of antigen-specific T cell immunity. To assess the potential of antigen targeting to dendritic cells to improve immunity, we incorporated ovalbumin protein into a monoclonal antibody to the DEC-205 receptor, an endocytic receptor that is abundant on these cells in lymphoid tissues. Simultaneously, we injected agonistic alpha-CD40 antibody to mature the dendritic cells. We found that a single low dose of antibody-conjugated ovalbumin initiated immunity from the naive CD4+ and CD8+ T cell repertoire. Unexpectedly, the alphaDEC-205 antigen conjugates, given s.c., targeted to dendritic cells systemically and for long periods, and ovalbumin peptide was presented on MHC class I for 2 weeks. This was associated with stronger CD8+ T cell-mediated immunity relative to other forms of antigen delivery, even when the latter was given at a thousand times higher doses. In parallel, the mice showed enhanced resistance to an established rapidly growing tumor and to viral infection at a mucosal site. By better harnessing the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models.

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Olivier P Joffre, David Sancho, +2 authors, Caetano Reis e Sousa.
Eur J Immunol, 2010 Mar 25; 40(5). PMID: 20333625    Free PMC article.
Langerhans cells as targets for immunotherapy against skin cancer.
Patrizia Stoitzner, Florian Sparber, Christoph H Tripp.
Immunol Cell Biol, 2010 Mar 31; 88(4). PMID: 20351746    Free PMC article.
Review.
Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy.
Nikolaus Romani, Martin Thurnher, +2 authors, Vincent Flacher.
Immunol Cell Biol, 2010 Apr 07; 88(4). PMID: 20368713    Free PMC article.
Review.
4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines.
Rajesh K Sharma, Rich-Henry Schabowsky, +8 authors, Haval Shirwan.
Cancer Res, 2010 Apr 22; 70(10). PMID: 20406989    Free PMC article.
Unravelling mononuclear phagocyte heterogeneity.
Frédéric Geissmann, Siamon Gordon, +2 authors, Gwendalyn J Randolph.
Nat Rev Immunol, 2010 May 15; 10(6). PMID: 20467425    Free PMC article.
Highly Cited. Review.
Directing dendritic cell immunotherapy towards successful cancer treatment.
Rachel Lubong Sabado, Nina Bhardwaj.
Immunotherapy, 2010 May 18; 2(1). PMID: 20473346    Free PMC article.
Review.
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.
Sarah L Jongbloed, Andrew J Kassianos, +10 authors, Kristen J Radford.
J Exp Med, 2010 May 19; 207(6). PMID: 20479116    Free PMC article.
Highly Cited.
The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells.
Karine Crozat, Rachel Guiton, +11 authors, Marc Dalod.
J Exp Med, 2010 May 19; 207(6). PMID: 20479118    Free PMC article.
Highly Cited.
Dendritic cell subsets as vectors and targets for improved cancer therapy.
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Curr Top Microbiol Immunol, 2010 May 22; 344. PMID: 20490776    Free PMC article.
Review.
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.
Eynav Klechevsky, Anne-Laure Flamar, +11 authors, Jacques Banchereau.
Blood, 2010 Jun 10; 116(10). PMID: 20530286    Free PMC article.
Highly Cited.
CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells.
Alice W Yewdall, Scott B Drutman, +2 authors, Nina Bhardwaj.
PLoS One, 2010 Jun 30; 5(6). PMID: 20585396    Free PMC article.
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody.
Cheolho Cheong, Jae-Hoon Choi, +13 authors, Chae Gyu Park.
Blood, 2010 Jul 30; 116(19). PMID: 20668230    Free PMC article.
Dendritic cells: are they clinically relevant?
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693842    Free PMC article.
Review.
The expanding family of dendritic cell subsets.
Hideki Ueno, A Karolina Palucka, Jacques Banchereau.
Nat Biotechnol, 2010 Aug 11; 28(8). PMID: 20697407
Dendritic cell-specific antigen delivery by coronavirus vaccine vectors induces long-lasting protective antiviral and antitumor immunity.
Luisa Cervantes-Barragan, Roland Züst, +8 authors, Volker Thiel.
mBio, 2010 Sep 17; 1(4). PMID: 20844609    Free PMC article.
Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates.
Kavita Tewari, Barbara J Flynn, +10 authors, Robert A Seder.
Vaccine, 2010 Sep 18; 28(45). PMID: 20846528    Free PMC article.
Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy.
Melissa Swiecki, Marco Colonna.
Eur J Immunol, 2010 Sep 21; 40(8). PMID: 20853492    Free PMC article.
Inhibitory C-type lectin receptors in myeloid cells.
Pierre Redelinghuys, Gordon D Brown.
Immunol Lett, 2010 Oct 12; 136(1). PMID: 20934454    Free PMC article.
Review.
From vaccines to memory and back.
Federica Sallusto, Antonio Lanzavecchia, Koichi Araki, Rafi Ahmed.
Immunity, 2010 Oct 30; 33(4). PMID: 21029957    Free PMC article.
Highly Cited. Review.
Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics.
Rachel S Friedman, Peter Beemiller, +2 authors, Matthew F Krummel.
J Exp Med, 2010 Nov 03; 207(12). PMID: 21041455    Free PMC article.
The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs.
Shannon J Turley, Anne L Fletcher, Kutlu G Elpek.
Nat Rev Immunol, 2010 Nov 20; 10(12). PMID: 21088682
Review.
Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes.
Benjamin G Keselowsky, Chang Qing Xia, Michael Clare-Salzler.
Hum Vaccin, 2010 Dec 16; 7(1). PMID: 21157186    Free PMC article.
Review.
DAI (DLM-1/ZBP1) as a genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity.
Alvaro Lladser, Dimitrios Mougiakakos, +4 authors, Karl Ljungberg.
Mol Ther, 2010 Dec 16; 19(3). PMID: 21157438    Free PMC article.
Dendritic cells and immunity against cancer.
K Palucka, H Ueno, J Fay, J Banchereau.
J Intern Med, 2010 Dec 17; 269(1). PMID: 21158979    Free PMC article.
Review.
Targeting skin dendritic cells to improve intradermal vaccination.
N Romani, V Flacher, +3 authors, P Stoitzner.
Curr Top Microbiol Immunol, 2011 Jan 22; 351. PMID: 21253784    Free PMC article.
Review.
The impact of nanoparticle ligand density on dendritic-cell targeted vaccines.
Arunima Bandyopadhyay, Rebecca L Fine, +2 authors, Tarek M Fahmy.
Biomaterials, 2011 Jan 26; 32(11). PMID: 21262534    Free PMC article.
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.
Juliana Idoyaga, Ashira Lubkin, +8 authors, Ralph M Steinman.
Proc Natl Acad Sci U S A, 2011 Jan 26; 108(6). PMID: 21262813    Free PMC article.
Highly Cited.
Targeting human dendritic cell subsets for improved vaccines.
Hideki Ueno, Eynav Klechevsky, +7 authors, Sangkon Oh.
Semin Immunol, 2011 Feb 01; 23(1). PMID: 21277223    Free PMC article.
Review.
A novel modular antigen delivery system for immuno targeting of human 6-sulfo LacNAc-positive blood dendritic cells (SlanDCs).
Claudia C Bippes, Anja Feldmann, +12 authors, Michael Bachmann.
PLoS One, 2011 Feb 02; 6(1). PMID: 21283706    Free PMC article.
Harnessing dendritic cells in inflammatory skin diseases.
Chung-Ching Chu, Paola Di Meglio, Frank O Nestle.
Semin Immunol, 2011 Feb 08; 23(1). PMID: 21295490    Free PMC article.
Review.
Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines.
Troels R Petersen, Dianne Sika-Paotonu, +2 authors, Ian F Hermans.
PLoS One, 2011 Apr 13; 6(3). PMID: 21483862    Free PMC article.
Immunogenicity of protein therapeutics: The key causes, consequences and challenges.
Matthew P Baker, Helen M Reynolds, Brooke Lumicisi, Christine J Bryson.
Self Nonself, 2011 Apr 14; 1(4). PMID: 21487506    Free PMC article.
Highly Cited.
Dendritic cell control of tolerogenic responses.
Santhakumar Manicassamy, Bali Pulendran.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488899    Free PMC article.
Highly Cited. Review.
Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks?
Slobodan Culina, Christian Boitard, Roberto Mallone.
Clin Dev Immunol, 2011 Jun 08; 2011. PMID: 21647401    Free PMC article.
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells.
Mark Melchers, Katie Matthews, +8 authors, Rogier W Sanders.
Retrovirology, 2011 Jun 22; 8. PMID: 21689404    Free PMC article.
A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies.
Jennifer Carlring, Evy De Leenheer, Andrew William Heath.
PLoS One, 2011 Aug 04; 6(7). PMID: 21811628    Free PMC article.
Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.
Fubin Li, Jeffrey V Ravetch.
Science, 2011 Aug 20; 333(6045). PMID: 21852502    Free PMC article.
Highly Cited.
Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.
Ning Li, Catherine Matte-Martone, +8 authors, Warren D Shlomchik.
Blood, 2011 Sep 16; 118(22). PMID: 21917752    Free PMC article.
Dendritic cell and macrophage heterogeneity in vivo.
Daigo Hashimoto, Jennifer Miller, Miriam Merad.
Immunity, 2011 Sep 29; 35(3). PMID: 21943488    Free PMC article.
Highly Cited.
Generation of antibody-producing hybridomas following one single immunization with a targeted DNA vaccine.
I Øynebråten, T-O Løvås, K Thompson, B Bogen.
Scand J Immunol, 2011 Oct 01; 75(4). PMID: 21955209    Free PMC article.
Targeting mucosal immunity in the battle to develop a mastitis vaccine.
Mini Bharathan, Isis K Mullarky.
J Mammary Gland Biol Neoplasia, 2011 Oct 05; 16(4). PMID: 21968537
Review.
A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo.
Austin Pantel, Cheolho Cheong, +8 authors, M Paula Longhi.
Eur J Immunol, 2011 Oct 18; 42(1). PMID: 22002164    Free PMC article.
Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses.
Ondrej Stanek, Irena Linhartova, +2 authors, Peter Sebo.
Mol Biotechnol, 2011 Oct 19; 51(3). PMID: 22006508
Codelivery of the chemokine CCL3 by an adenovirus-based vaccine improves protection from retrovirus infection.
Ruth Lietz, Wibke Bayer, +6 authors, Oliver Wildner.
J Virol, 2011 Nov 18; 86(3). PMID: 22090142    Free PMC article.
Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity.
C Trumpfheller, M P Longhi, +5 authors, R M Steinman.
J Intern Med, 2011 Dec 01; 271(2). PMID: 22126373    Free PMC article.
Review.
T cells as vehicles for cancer vaccination.
Adham S Bear, Conrad R Cruz, Aaron E Foster.
J Biomed Biotechnol, 2011 Dec 02; 2011. PMID: 22131805    Free PMC article.
Review.
Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome.
M Catucci, F Prete, +7 authors, A Villa.
Gene Ther, 2011 Dec 23; 19(12). PMID: 22189416    Free PMC article.
Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.
Hiroaki Hemmi, Neeha Zaidi, +10 authors, Juliana Idoyaga.
J Immunol, 2012 Jan 03; 188(3). PMID: 22210914    Free PMC article.
Signaling by myeloid C-type lectin receptors in immunity and homeostasis.
David Sancho, Caetano Reis e Sousa.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224766    Free PMC article.
Highly Cited. Review.
CD40-targeted adenoviral cancer vaccines: the long and winding road to the clinic.
Basav N Hangalapura, Laura Timares, +3 authors, Tanja D de Gruijl.
J Gene Med, 2012 Jan 10; 14(6). PMID: 22228547    Free PMC article.
Review.
C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses.
Lara M Kingeter, Xin Lin.
Cell Mol Immunol, 2012 Jan 17; 9(2). PMID: 22246129    Free PMC article.
Review.
Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals.
Chae Gyu Park, Anthony Rodriguez, +4 authors, Ralph M Steinman.
J Immunol Methods, 2012 Jan 26; 377(1-2). PMID: 22273672    Free PMC article.
Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses.
Vincent Flacher, Christoph H Tripp, +5 authors, Nikolaus Romani.
J Immunol, 2012 Feb 01; 188(5). PMID: 22291181    Free PMC article.
DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration.
Jimmy Jianheng Zhou, Yuan Min Wang, +11 authors, Anne M Durkan.
Int J Clin Exp Med, 2012 Feb 14; 5(1). PMID: 22328945    Free PMC article.
Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein.
Dharmendra Raghuwanshi, Vivek Mishra, +2 authors, Mavanur R Suresh.
Mol Pharm, 2012 Feb 24; 9(4). PMID: 22356166    Free PMC article.
Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice.
Bei Wang, Neeha Zaidi, +4 authors, Ralph M Steinman.
Breast Cancer Res, 2012 Mar 09; 14(2). PMID: 22397502    Free PMC article.
Beyond empiricism: informing vaccine development through innate immunity research.
Stuart M Levitz, Douglas T Golenbock.
Cell, 2012 Mar 20; 148(6). PMID: 22424235    Free PMC article.
Review.
Cancer immunotherapy via dendritic cells.
Karolina Palucka, Jacques Banchereau.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871    Free PMC article.
Highly Cited. Review.
Inflammatory spleen monocytes can upregulate CD11c expression without converting into dendritic cells.
Scott B Drutman, Julia C Kendall, E Sergio Trombetta.
J Immunol, 2012 Mar 24; 188(8). PMID: 22442444    Free PMC article.
Cross-presentation: how to get there - or how to get the ER.
Christoph Kreer, Judith Rauen, Matthias Zehner, Sven Burgdorf.
Front Immunol, 2011 Jan 01; 2. PMID: 22566876    Free PMC article.
Targeting Dendritic Cells in vivo for Cancer Therapy.
Irina Caminschi, Eugene Maraskovsky, William Ross Heath.
Front Immunol, 2012 May 09; 3. PMID: 22566899    Free PMC article.
PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines.
Bingbing Dai, Liang Xiao, +2 authors, Pin Wang.
Mol Ther, 2012 May 17; 20(9). PMID: 22588271    Free PMC article.
Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques.
Matthias Tenbusch, Ralf Ignatius, +10 authors, Klaus Uberla.
PLoS One, 2012 Jun 22; 7(6). PMID: 22720025    Free PMC article.
Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer.
Evelyne Béraud, Aurélie Collignon, +3 authors, Eric Mas.
Oncoimmunology, 2012 Jun 22; 1(1). PMID: 22720212    Free PMC article.
Human macrophages and dendritic cells can equally present MART-1 antigen to CD8(+) T cells after phagocytosis of gamma-irradiated melanoma cells.
María Marcela Barrio, Riad Abes, +7 authors, Jean-Luc Teillaud.
PLoS One, 2012 Jul 07; 7(7). PMID: 22768350    Free PMC article.
Cross-presentation by dendritic cells.
Olivier P Joffre, Elodie Segura, Ariel Savina, Sebastian Amigorena.
Nat Rev Immunol, 2012 Jul 14; 12(8). PMID: 22790179
Highly Cited. Review.
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells.
Muzlifah Haniffa, Amanda Shin, +25 authors, Florent Ginhoux.
Immunity, 2012 Jul 17; 37(1). PMID: 22795876    Free PMC article.
Highly Cited.
Microparticle surface modifications targeting dendritic cells for non-activating applications.
Jamal S Lewis, Toral D Zaveri, Charles P Crooks, Benjamin G Keselowsky.
Biomaterials, 2012 Jul 17; 33(29). PMID: 22796161    Free PMC article.
Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.
Martin Kreutz, Benoit Giquel, +5 authors, Sandra S Diebold.
PLoS One, 2012 Jul 19; 7(7). PMID: 22808118    Free PMC article.
CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation.
Nicole M Beauchamp, Rama D Yammani, Martha A Alexander-Miller.
J Virol, 2012 Jul 20; 86(19). PMID: 22811544    Free PMC article.
Characterization of epitope-tagged foot-and-mouth disease virus.
Julian Seago, Terry Jackson, +5 authors, Nicholas Juleff.
J Gen Virol, 2012 Jul 21; 93(Pt 11). PMID: 22815275    Free PMC article.
Cross-presentation of IgG-containing immune complexes.
Kristi Baker, Timo Rath, +2 authors, Richard S Blumberg.
Cell Mol Life Sci, 2012 Aug 01; 70(8). PMID: 22847331    Free PMC article.
Review.
Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials.
Aurélie Moreau, Emilie Varey, +4 authors, Maria-Cristina Cuturi.
Front Immunol, 2012 Aug 22; 3. PMID: 22908013    Free PMC article.
The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells.
Carlo Manzo, Juan A Torreno-Pina, +6 authors, Alessandra Cambi.
J Biol Chem, 2012 Sep 29; 287(46). PMID: 23019323    Free PMC article.
Dendritic cell-based vaccines: barriers and opportunities.
Jessica A Cintolo, Jashodeep Datta, Sarah J Mathew, Brian J Czerniecki.
Future Oncol, 2012 Nov 08; 8(10). PMID: 23130928    Free PMC article.
Review.
Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: a novel tool for specific immunotherapy.
Esther E Weinberger, Martin Himly, +6 authors, Richard Weiss.
J Control Release, 2012 Nov 14; 165(2). PMID: 23147517    Free PMC article.
An anti-nucleic acid antibody delivers antigen to the cross-presentation pathway in dendritic cells and potentiates therapeutic antitumor effects.
Chuong D Pham, Min-Yeong Woo, +2 authors, Myung-Hee Kwon.
J Immunol, 2012 Nov 16; 189(12). PMID: 23152565    Free PMC article.
Trial watch: Dendritic cell-based interventions for cancer therapy.
Lorenzo Galluzzi, Laura Senovilla, +7 authors, Guido Kroemer.
Oncoimmunology, 2012 Nov 22; 1(7). PMID: 23170259    Free PMC article.
Highly Cited.
Dendritic cells and vaccine design for sexually-transmitted diseases.
Dorothee Duluc, Julien Gannevat, +7 authors, Sangkon Oh.
Microb Pathog, 2012 Dec 04; 58. PMID: 23201532    Free PMC article.
Review.
Streamlined expressed protein ligation using split inteins.
Miquel Vila-Perelló, Zhihua Liu, +3 authors, Tom W Muir.
J Am Chem Soc, 2012 Dec 26; 135(1). PMID: 23265282    Free PMC article.
New generation of dendritic cell vaccines.
Kristen J Radford, Irina Caminschi.
Hum Vaccin Immunother, 2013 Jan 08; 9(2). PMID: 23291951    Free PMC article.
Review.
Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205.
Carol S Leung, Michael A Maurer, +6 authors, Christian Münz.
Blood, 2013 Jan 09; 121(9). PMID: 23297134    Free PMC article.
Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.
Lee Kim Swee, Carla P Guimaraes, +3 authors, Hidde L Ploegh.
Proc Natl Acad Sci U S A, 2013 Jan 09; 110(4). PMID: 23297227    Free PMC article.
Pathways of antigen processing.
Janice S Blum, Pamela A Wearsch, Peter Cresswell.
Annu Rev Immunol, 2013 Jan 10; 31. PMID: 23298205    Free PMC article.
Highly Cited. Review.
Specialized role of migratory dendritic cells in peripheral tolerance induction.
Juliana Idoyaga, Christopher Fiorese, +6 authors, Ralph M Steinman.
J Clin Invest, 2013 Jan 10; 123(2). PMID: 23298832    Free PMC article.
Highly Cited.
Normal T cell selection occurs in CD205-deficient thymic microenvironments.
William E Jenkinson, Kyoko Nakamura, +2 authors, Graham Anderson.
PLoS One, 2013 Jan 10; 7(12). PMID: 23300927    Free PMC article.
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells.
Scott Barbuto, Juliana Idoyaga, +4 authors, Tom W Muir.
Nat Chem Biol, 2013 Feb 19; 9(4). PMID: 23416331    Free PMC article.
In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine.
Pan Tao, Marthandan Mahalingam, +3 authors, Venigalla B Rao.
Proc Natl Acad Sci U S A, 2013 Mar 27; 110(15). PMID: 23530211    Free PMC article.
Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting.
Federico Perche, Vladimir P Torchilin.
J Drug Deliv, 2013 Mar 28; 2013. PMID: 23533772    Free PMC article.
Biomimetic antigenic nanoparticles elicit controlled protective immune response to influenza.
Dustin P Patterson, Agnieszka Rynda-Apple, +2 authors, Trevor Douglas.
ACS Nano, 2013 Apr 02; 7(4). PMID: 23540530    Free PMC article.
Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells.
Elodie Segura, Mélanie Durand, Sebastian Amigorena.
J Exp Med, 2013 Apr 10; 210(5). PMID: 23569327    Free PMC article.
Highly Cited.
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.
Diane Tseng, Jens-Peter Volkmer, +8 authors, Irving L Weissman.
Proc Natl Acad Sci U S A, 2013 May 22; 110(27). PMID: 23690610    Free PMC article.
Highly Cited.
Skin-resident antigen-presenting cells: instruction manual for vaccine development.
Cynthia M Fehres, Juan J Garcia-Vallejo, Wendy W J Unger, Yvette van Kooyk.
Front Immunol, 2013 Jun 27; 4. PMID: 23801994    Free PMC article.
Targeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccination.
Cathleen Petzold, Sonja Schallenberg, Joel N H Stern, Karsten Kretschmer.
Rev Diabet Stud, 2012 Jan 01; 9(4). PMID: 23804268    Free PMC article.
Review.
Targeting Leishmania major Antigens to Dendritic Cells In Vivo Induces Protective Immunity.
Ines Matos, Olga Mizenina, +2 authors, Juliana Idoyaga.
PLoS One, 2013 Jul 11; 8(6). PMID: 23840706    Free PMC article.
Therapeutic cancer vaccines: past, present, and future.
Chunqing Guo, Masoud H Manjili, +3 authors, Xiang-Yang Wang.
Adv Cancer Res, 2013 Jul 23; 119. PMID: 23870514    Free PMC article.
Highly Cited. Review.
Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challenge.
Hugo R Henriques, Eline V Rampazo, +8 authors, Silvia B Boscardin.
PLoS Negl Trop Dis, 2013 Jul 23; 7(7). PMID: 23875054    Free PMC article.
DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice.
Jun Cao, Yiqi Jin, +6 authors, Jian Yan.
BMC Immunol, 2013 Aug 15; 14. PMID: 23941509    Free PMC article.
DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1.
Gayatri Mukherjee, Ari Geliebter, +6 authors, Teresa P DiLorenzo.
Int Immunol, 2013 Sep 12; 25(11). PMID: 24021877    Free PMC article.
Delivery strategies for novel vaccine formulations.
Maria Trovato, Shelly J Krebs, Nancy L Haigwood, Piergiuseppe De Berardinis.
World J Virol, 2012 Feb 12; 1(1). PMID: 24175206    Free PMC article.
C-type Lectin Receptors for Tumor Eradication: Future Directions.
Ingeborg Streng-Ouwehand, Wendy W J Unger, Yvette Van Kooyk.
Cancers (Basel), 2011 Jan 01; 3(3). PMID: 24212951    Free PMC article.
A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation.
Ding Zhang, Cai-Feng Chen, +7 authors, You-Wen He.
PLoS One, 2013 Nov 28; 8(11). PMID: 24278299    Free PMC article.
Trial watch: Dendritic cell-based interventions for cancer therapy.
Erika Vacchelli, Ilio Vitale, +8 authors, Lorenzo Galluzzi.
Oncoimmunology, 2013 Nov 29; 2(10). PMID: 24286020    Free PMC article.
Review.
Combinatorial peptide libraries: mining for cell-binding peptides.
Bethany Powell Gray, Kathlynn C Brown.
Chem Rev, 2013 Dec 05; 114(2). PMID: 24299061    Free PMC article.
Review.
Dendritic cell-targeted approaches to modulate immune dysfunction in the tumor microenvironment.
Anne Gallois, Nina Bhardwaj.
Front Immunol, 2013 Dec 18; 4. PMID: 24339825    Free PMC article.
Review.
Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells.
Semih U Tareen, Brenna Kelley-Clarke, +10 authors, Scott H Robbins.
Mol Ther, 2014 Jan 15; 22(3). PMID: 24419083    Free PMC article.
Human blood dendritic cell subsets exhibit discriminative pattern recognition receptor profiles.
Kristina Lundberg, Frida Rydnert, Lennart Greiff, Malin Lindstedt.
Immunology, 2014 Jan 22; 142(2). PMID: 24444310    Free PMC article.
Trial Watch: Peptide vaccines in cancer therapy.
Fernando Aranda, Erika Vacchelli, +6 authors, Lorenzo Galluzzi.
Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498550    Free PMC article.
Review.
A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.
Jianping Yuan, Satoshi Kashiwagi, +20 authors, Mark C Poznansky.
J Hematol Oncol, 2014 Feb 26; 7. PMID: 24565018    Free PMC article.
Self-antigen presentation by dendritic cells in autoimmunity.
Ann-Katrin Hopp, Anne Rupp, Veronika Lukacs-Kornek.
Front Immunol, 2014 Mar 05; 5. PMID: 24592266    Free PMC article.
Review.
Mucosal dendritic cells shape mucosal immunity.
Sun-Young Chang, Hyun-Jeong Ko, Mi-Na Kweon.
Exp Mol Med, 2014 Mar 15; 46. PMID: 24626170    Free PMC article.
Review.
Aptamer-targeted antigen delivery.
Brian C Wengerter, Joseph A Katakowski, +4 authors, Matthew Levy.
Mol Ther, 2014 Apr 01; 22(7). PMID: 24682172    Free PMC article.
An engineered non-toxic superantigen increases cross presentation of hepatitis B virus nucleocapsids by human dendritic cells.
Julie D McIntosh, Kristy Manning, +4 authors, John A Taylor.
PLoS One, 2014 Apr 03; 9(4). PMID: 24690680    Free PMC article.
Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205.
Madhav V Dhodapkar, Mario Sznol, +16 authors, Tibor Keler.
Sci Transl Med, 2014 Apr 18; 6(232). PMID: 24739759    Free PMC article.
Highly Cited.
Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells.
V Cerovic, S A Houston, +10 authors, S W F Milling.
Mucosal Immunol, 2014 May 23; 8(1). PMID: 24850430    Free PMC article.
Vaccine strategies utilizing C-type lectin receptors on dendritic cells in vivo.
Chae Gyu Park.
Clin Exp Vaccine Res, 2014 Jul 09; 3(2). PMID: 25003088    Free PMC article.
Review.
Inflammatory conditions distinctively alter immunological functions of Langerhans-like cells and dendritic cells in vitro.
André Said, Stephanie Bock, Gerrit Müller, Günther Weindl.
Immunology, 2014 Jul 26; 144(2). PMID: 25059418    Free PMC article.
Targeting human dendritic cells in situ to improve vaccines.
Kartik Sehgal, Kavita M Dhodapkar, Madhav V Dhodapkar.
Immunol Lett, 2014 Jul 30; 162(1 Pt A). PMID: 25072116    Free PMC article.
Review.
Current status of cancer immunotherapy.
K Kono.
J Stem Cells Regen Med, 2014 Jul 31; 10(1). PMID: 25075156    Free PMC article.
Review.
Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance.
Vincent Flacher, Christoph H Tripp, +4 authors, Nikolaus Romani.
EMBO Mol Med, 2014 Aug 03; 6(9). PMID: 25085878    Free PMC article.
The Role of FcRn in Antigen Presentation.
Kristi Baker, Timo Rath, Michal Pyzik, Richard S Blumberg.
Front Immunol, 2014 Sep 16; 5. PMID: 25221553    Free PMC article.
Review.
Targeting DNA vaccines to myeloid cells using a small peptide.
Chunting Ye, Jang Gi Choi, +2 authors, N Manjunath.
Eur J Immunol, 2014 Oct 02; 45(1). PMID: 25270431    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
In vivo mechanisms involved in enhanced protection utilizing an Fc receptor-targeted mucosal vaccine platform in a bacterial vaccine and challenge model.
Constantine Bitsaktsis, Zulfia Babadjanova, Edmund J Gosselin.
Infect Immun, 2014 Oct 15; 83(1). PMID: 25312957    Free PMC article.
Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine.
Li-Zhen He, Jeffrey Weidlick, +2 authors, Tibor Keler.
Cell Mol Immunol, 2014 Oct 28; 12(6). PMID: 25345808    Free PMC article.
Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders.
Leonie Hussaarts, Maria Yazdanbakhsh, Bruno Guigas.
Front Immunol, 2014 Nov 05; 5. PMID: 25368615    Free PMC article.
Review.
Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen.
Sandeep S Saluja, Douglas J Hanlon, +6 authors, Richard L Edelson.
Int J Nanomedicine, 2014 Nov 25; 9. PMID: 25419128    Free PMC article.
A novel method for synthetic vaccine construction based on protein assembly.
Zhida Liu, Hang Zhou, +3 authors, Mingzhao Zhu.
Sci Rep, 2014 Dec 02; 4. PMID: 25434527    Free PMC article.
Engineering better immunotherapies via RNA interference.
Mouldy Sioud.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483669    Free PMC article.
Review.
Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses.
Henrike Veninga, Ellen G F Borg, +6 authors, Joke M M den Haan.
Eur J Immunol, 2014 Dec 10; 45(3). PMID: 25487358    Free PMC article.
Targeting Dendritic Cells as a Good Alternative to Combat Leishmania spp.
Rafael Freitas-Silva, Maria Carolina Accioly Brelaz-de-Castro, Antônio Mauro Rezende, Valéria Rêgo Pereira.
Front Immunol, 2014 Dec 17; 5. PMID: 25505469    Free PMC article.
Review.
Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments.
Dorothée Duluc, Romain Banchereau, +12 authors, SangKon Oh.
Genome Med, 2014 Dec 19; 6(11). PMID: 25520755    Free PMC article.
Past, present and future targets for immunotherapy in ovarian cancer.
Carlton L Schwab, Diana P English, +2 authors, Alessandro D Santin.
Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524384    Free PMC article.
Review.
Classification of current anticancer immunotherapies.
Lorenzo Galluzzi, Erika Vacchelli, +85 authors, Guido Kroemer.
Oncotarget, 2014 Dec 30; 5(24). PMID: 25537519    Free PMC article.
Highly Cited. Review.
Virological and preclinical characterization of a dendritic cell targeting, integration-deficient lentiviral vector for cancer immunotherapy.
Jared M Odegard, Brenna Kelley-Clarke, +10 authors, Scott H Robbins.
J Immunother, 2015 Feb 07; 38(2). PMID: 25658613    Free PMC article.
Antigen targeting to dendritic cells allows the identification of a CD4 T-cell epitope within an immunodominant Trypanosoma cruzi antigen.
Eline V Rampazo, Kelly N S Amorim, +3 authors, Silvia B Boscardin.
PLoS One, 2015 Feb 14; 10(2). PMID: 25679777    Free PMC article.
The ins and outs of MHC class II-mediated antigen processing and presentation.
Paul A Roche, Kazuyuki Furuta.
Nat Rev Immunol, 2015 Feb 28; 15(4). PMID: 25720354    Free PMC article.
Highly Cited. Review.
β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10.
Chunmei Fu, Xinjun Liang, +7 authors, Aimin Jiang.
Proc Natl Acad Sci U S A, 2015 Mar 03; 112(9). PMID: 25730849    Free PMC article.
Clinical significance of immunotherapy with combined three kinds of cells for operable colorectal cancer.
Xiao-Hui Du, Hai-Liang Liu, +7 authors, Ying-Xin Xu.
Tumour Biol, 2015 Mar 13; 36(7). PMID: 25764087
Optimization of multi-epitopic HIV-1 recombinant protein expression in prokaryote system and conjugation to mouse DEC-205 monoclonal antibody: implication for in-vivo targeted delivery of dendritic cells.
Roghayeh Rahimi, Massoumeh Ebtekar, +2 authors, Mehdi Mahdavi.
Iran J Basic Med Sci, 2015 Mar 27; 18(2). PMID: 25810888    Free PMC article.
DNA vaccines encoding DEC205-targeted antigens: immunity or tolerance?
Thomas Niezold, Michael Storcksdieck Genannt Bonsmann, +8 authors, Matthias Tenbusch.
Immunology, 2015 Mar 31; 145(4). PMID: 25819746    Free PMC article.
Guiding principles in the design of molecular bioconjugates for vaccine applications.
Haipeng Liu, Darrell J Irvine.
Bioconjug Chem, 2015 Mar 31; 26(5). PMID: 25822926    Free PMC article.
Review.
Antigen delivery by filamentous bacteriophage fd displaying an anti-DEC-205 single-chain variable fragment confers adjuvanticity by triggering a TLR9-mediated immune response.
Rossella Sartorius, Luciana D'Apice, +9 authors, Piergiuseppe De Berardinis.
EMBO Mol Med, 2015 Apr 19; 7(7). PMID: 25888235    Free PMC article.
A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40.
Jingtao Chen, Gerard Zurawski, +8 authors, A Karolina Palucka.
J Hematol Oncol, 2015 Apr 19; 8. PMID: 25888530    Free PMC article.
ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis.
Aarón Silva-Sánchez, Selene Meza-Pérez, +7 authors, Leopoldo Flores-Romo.
PLoS One, 2015 Apr 29; 10(4). PMID: 25915045    Free PMC article.
Trial watch: Dendritic cell-based anticancer therapy.
Norma Bloy, Jonathan Pol, +11 authors, Lorenzo Galluzzi.
Oncoimmunology, 2015 May 06; 3(11). PMID: 25941593    Free PMC article.
Review.
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
Matías Alejandro Molina, Ailén Magalí Díaz, +8 authors, Marcela Alejandra Manghi.
PLoS One, 2015 May 16; 10(5). PMID: 25978357    Free PMC article.
A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells.
Melissa Santone, Susanna Aprea, +10 authors, Ugo D'Oro.
Hum Vaccin Immunother, 2015 May 30; 11(8). PMID: 26024409    Free PMC article.
Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production.
Adriana Flores-Langarica, Saeeda Bobat, +10 authors, Adam F Cunningham.
Eur J Immunol, 2015 Jun 04; 45(8). PMID: 26036767    Free PMC article.
pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205.
Longxing Cao, Xiangyi Shi, +2 authors, Yongning He.
Proc Natl Acad Sci U S A, 2015 Jun 04; 112(23). PMID: 26039988    Free PMC article.
Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions.
Thien-Phong Vu Manh, Nicolas Bertho, +2 authors, Marc Dalod.
Front Immunol, 2015 Jun 18; 6. PMID: 26082777    Free PMC article.
Review.
Trial Watch: Peptide-based anticancer vaccines.
Jonathan Pol, Norma Bloy, +8 authors, Lorenzo Galluzzi.
Oncoimmunology, 2015 Jul 03; 4(4). PMID: 26137405    Free PMC article.
Review.
A multi-trimeric fusion of CD40L and gp100 tumor antigen activates dendritic cells and enhances survival in a B16-F10 melanoma DNA vaccine model.
Sachin Gupta, James M Termini, +5 authors, Geoffrey W Stone.
Vaccine, 2015 Aug 05; 33(38). PMID: 26241951    Free PMC article.
Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo.
Anne-Laure Flamar, Vanessa Contreras, +7 authors, Yves Levy.
PLoS One, 2015 Sep 26; 10(9). PMID: 26407317    Free PMC article.
Delivery of siRNAs to Dendritic Cells Using DEC205-Targeted Lipid Nanoparticles to Inhibit Immune Responses.
Joseph A Katakowski, Gayatri Mukherjee, +5 authors, Deborah Palliser.
Mol Ther, 2015 Sep 29; 24(1). PMID: 26412590    Free PMC article.
Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells.
Cynthia M Fehres, Sanne Duinkerken, +7 authors, Yvette van Kooyk.
Cell Mol Immunol, 2015 Oct 13; 14(4). PMID: 26456691    Free PMC article.
Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy.
Jardin Leleux, Alexandra Atalis, Krishnendu Roy.
J Control Release, 2015 Oct 23; 219. PMID: 26489733    Free PMC article.
Review.
Minor histocompatibility Ags: identification strategies, clinical results and translational perspectives.
R Oostvogels, H M Lokhorst, T Mutis.
Bone Marrow Transplant, 2015 Oct 27; 51(2). PMID: 26501766
Review.
The Use of Synthetic Carriers in Malaria Vaccine Design.
Liam Powles, Sue D Xiang, Cordelia Selomulya, Magdalena Plebanski.
Vaccines (Basel), 2015 Nov 04; 3(4). PMID: 26529028    Free PMC article.
Review.
Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses.
Björn E Clausen, Patrizia Stoitzner.
Front Immunol, 2015 Nov 12; 6. PMID: 26557117    Free PMC article.
Review.
Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines.
Cleo Goyvaerts, Karine Breckpot.
J Immunol Res, 2015 Nov 20; 2015. PMID: 26583156    Free PMC article.
Review.
Multilayered Graphene Nano-Film for Controlled Protein Delivery by Desired Electro-Stimuli.
Moonhyun Choi, Kyung-Geun Kim, +3 authors, Jinkee Hong.
Sci Rep, 2015 Dec 02; 5. PMID: 26621344    Free PMC article.
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
Adriana M Mujal, Julia K Gilden, +2 authors, Matthew F Krummel.
Nat Immunol, 2015 Dec 23; 17(3). PMID: 26692174    Free PMC article.
A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract.
D Ruane, Y Do, +7 authors, S Mehandru.
Mucosal Immunol, 2016 Jan 07; 9(5). PMID: 26732678    Free PMC article.
PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity.
A L Silva, P C Soema, +2 authors, W Jiskoot.
Hum Vaccin Immunother, 2016 Jan 12; 12(4). PMID: 26752261    Free PMC article.
Review.
T Cell Vaccinology: Beyond the Reflection of Infectious Responses.
Nathan D Pennock, Justin D Kedl, Ross M Kedl.
Trends Immunol, 2016 Feb 03; 37(3). PMID: 26830540    Free PMC article.
Review.
Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance.
Christopher J Nirschl, Niroshana Anandasabapathy.
Hum Vaccin Immunother, 2016 Feb 03; 12(1). PMID: 26836327    Free PMC article.
Review.
The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells.
Adnen Faddaoui, Magdalena Bachvarova, +8 authors, Dimcho Bachvarov.
Oncotarget, 2016 Feb 13; 7(12). PMID: 26871602    Free PMC article.
Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.
Ingeborg Streng-Ouwehand, Nataschja I Ho, +9 authors, Yvette van Kooyk.
Elife, 2016 Mar 22; 5. PMID: 26999763    Free PMC article.
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies.
Christian H K Lehmann, Lukas Heger, +4 authors, Diana Dudziak.
Vaccines (Basel), 2016 Apr 05; 4(2). PMID: 27043640    Free PMC article.
Review.
IL-12p40/IL-10 Producing preCD8α/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection.
David Torres, Arnaud Köhler, +4 authors, Véronique Flamand.
PLoS Pathog, 2016 Apr 14; 12(4). PMID: 27074026    Free PMC article.
Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells.
Wenjie Yin, Laurent Gorvel, +13 authors, SangKon Oh.
EBioMedicine, 2016 Apr 15; 5. PMID: 27077111    Free PMC article.
Targeting dendritic cells: a promising strategy to improve vaccine effectiveness.
Christophe Macri, Claire Dumont, Angus Pr Johnston, Justine D Mintern.
Clin Transl Immunology, 2016 May 25; 5(3). PMID: 27217957    Free PMC article.
Highly Cited. Review.
A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy.
Zhongyi Yan, Yahong Wu, +11 authors, Yuanming Qi.
Oncotarget, 2016 Oct 27; 7(26). PMID: 27250027    Free PMC article.
Immunotherapy: Cancer vaccine triggers antiviral-type defences.
Jolanda De Vries, Carl Figdor.
Nature, 2016 Jun 10; 534(7607). PMID: 27281206
CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells.
Qianqian Zhang, Hehua Dai, +6 authors, Fadi G Lakkis.
J Immunol, 2016 Jul 01; 197(4). PMID: 27357151    Free PMC article.
In vitro-activated tumor-specific T lymphocytes prolong the survival of patients with advanced gastric cancer: a retrospective cohort study.
Jun Kuai, Fang Yang, +2 authors, Bao-Qin Gao.
Onco Targets Ther, 2016 Jul 07; 9. PMID: 27382313    Free PMC article.
A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice.
Zhida Liu, Hang Zhou, +2 authors, Mingzhao Zhu.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471615    Free PMC article.
Advances and challenges: dendritic cell vaccination strategies for glioblastoma.
Teilo H Schaller, John H Sampson.
Expert Rev Vaccines, 2016 Aug 09; 16(1). PMID: 27500911    Free PMC article.
Review.
Immunoregulatory functions of immune complexes in vaccine and therapy.
Yu-Mei Wen, Libing Mu, Yan Shi.
EMBO Mol Med, 2016 Aug 31; 8(10). PMID: 27572622    Free PMC article.
Review.
T-Regulatory Cells and Vaccination "Pay Attention and Do Not Neglect Them": Lessons from HIV and Cancer Vaccine Trials.
Vedran Brezar, Véronique Godot, +3 authors, Nabila Seddiki.
Vaccines (Basel), 2016 Sep 09; 4(3). PMID: 27608046    Free PMC article.
Review.
Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition.
Kirsteen M Tullett, Ingrid M Leal Rojas, +8 authors, Kristen J Radford.
JCI Insight, 2016 Oct 05; 1(7). PMID: 27699265    Free PMC article.
Role of heterogeneous cell population on modulation of dendritic cell phenotype and activation of CD8 T cells for use in cell-based immunotherapies.
Hannah Frizzell, Jaehyung Park, Natacha Comandante Lou, Kim A Woodrow.
Cell Immunol, 2016 Oct 30; 311. PMID: 27793335    Free PMC article.
Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs.
Joao N Duarte, Juan J Cragnolini, +8 authors, Hidde L Ploegh.
J Immunol, 2016 Nov 09; 197(12). PMID: 27821668    Free PMC article.
Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205.
Longxing Cao, Haishuang Chang, +2 authors, Yongning He.
Proc Natl Acad Sci U S A, 2016 Nov 09; 113(47). PMID: 27821726    Free PMC article.
The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells.
Kelly N S Amorim, Eline V Rampazo, +4 authors, Silvia B Boscardin.
Sci Rep, 2016 Dec 22; 6. PMID: 28000705    Free PMC article.
Characterization of a Broadly Reactive Anti-CD40 Agonistic Monoclonal Antibody for Potential Use as an Adjuvant.
Cameron Martin, Suryakant D Waghela, +9 authors, Waithaka Mwangi.
PLoS One, 2017 Jan 21; 12(1). PMID: 28107431    Free PMC article.
Dendritic cell targeting vaccine for HPV-associated cancer.
Wenjie Yin, Dorothée Duluc, HyeMee Joo, SangKon Oh.
Cancer Cell Microenviron, 2017 Jan 31; 3(4). PMID: 28133621    Free PMC article.
Dendritic Cells Cross-Present Immunogenic Lentivector-Encoded Antigen from Transduced Cells to Prime Functional T Cell Immunity.
Alastair Hotblack, Sara Seshadri, +4 authors, Clare L Bennett.
Mol Ther, 2017 Feb 06; 25(2). PMID: 28153097    Free PMC article.
CIITA-driven MHC class II expressing tumor cells can efficiently prime naive CD4+ TH cells in vivo and vaccinate the host against parental MHC-II-negative tumor cells.
Farah Bou Nasser Eddine, Greta Forlani, +3 authors, Roberto S Accolla.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197387    Free PMC article.
Dendritic Cell Targeting Effectively Boosts T Cell Responses Elicited by an HIV Multiepitope DNA Vaccine.
Juliana de Souza Apostólico, Victória Alves Santos Lunardelli, +4 authors, Daniela Santoro Rosa.
Front Immunol, 2017 Feb 23; 8. PMID: 28223987    Free PMC article.
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.
Julia Volckmar, Marcus Gereke, +11 authors, Dunja Bruder.
Sci Rep, 2017 Mar 08; 7. PMID: 28266658    Free PMC article.
Influence of protein fold stability on immunogenicity and its implications for vaccine design.
Sandra Scheiblhofer, Josef Laimer, +2 authors, Josef Thalhamer.
Expert Rev Vaccines, 2017 Mar 16; 16(5). PMID: 28290225    Free PMC article.
Review.
Transmembrane TNF-dependent uptake of anti-TNF antibodies.
Arun Deora, Subramanya Hegde, +15 authors, Tariq Ghayur.
MAbs, 2017 Mar 23; 9(4). PMID: 28323513    Free PMC article.
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
Christian H K Lehmann, Anna Baranska, +15 authors, Diana Dudziak.
J Exp Med, 2017 Apr 09; 214(5). PMID: 28389502    Free PMC article.
Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia.
Xiufen Chen, Dominick Fosco, Douglas E Kline, Justin Kline.
Oncoimmunology, 2017 May 17; 6(4). PMID: 28507789    Free PMC article.
Primary Human Blood Dendritic Cells for Cancer Immunotherapy-Tailoring the Immune Response by Dendritic Cell Maturation.
Simone P Sittig, I Jolanda M de Vries, Gerty Schreibelt.
Biomedicines, 2015 Dec 02; 3(4). PMID: 28536413    Free PMC article.
Review.
IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.
Christopher J Nirschl, Mayte Suárez-Fariñas, +26 authors, Niroshana Anandasabapathy.
Cell, 2017 Jul 01; 170(1). PMID: 28666115    Free PMC article.
Highly Cited.
Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines.
Dieke van Dinther, Dorian A Stolk, +3 authors, Joke M M den Haan.
J Leukoc Biol, 2017 Jul 22; 102(4). PMID: 28729358    Free PMC article.
Review.
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin.
Charlotte Deloizy, Even Fossum, +16 authors, Isabelle Schwartz-Cornil.
Sci Rep, 2017 Aug 11; 7(1). PMID: 28794452    Free PMC article.
Trial watch: Dendritic cell-based anticancer immunotherapy.
Abhishek D Garg, Monica Vara Perez, +4 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811970    Free PMC article.
Highly Cited. Review.
Nanomaterials for cancer immunotherapy.
Wantong Song, Sara N Musetti, Leaf Huang.
Biomaterials, 2017 Sep 30; 148. PMID: 28961532    Free PMC article.
Review.
Dendritic cell targeted HIV-1 gag protein vaccine provides help to a recombinant Newcastle disease virus vectored vaccine including mobilization of protective CD8+ T cells.
Loveline N Ngu, Nadesh N Nji, +17 authors, Godwin W Nchinda.
Immun Inflamm Dis, 2017 Dec 06; 6(1). PMID: 29205929    Free PMC article.
Towards personalized, tumour-specific, therapeutic vaccines for cancer.
Zhuting Hu, Patrick A Ott, Catherine J Wu.
Nat Rev Immunol, 2017 Dec 12; 18(3). PMID: 29226910    Free PMC article.
Highly Cited. Review.
Immunotherapy in ovarian cancer.
K Odunsi.
Ann Oncol, 2017 Dec 13; 28(suppl_8). PMID: 29232467    Free PMC article.
Review.
CpG Oligodeoxinucleotides and Flagellin Modulate the Immune Response to Antigens Targeted to CD8α+ and CD8α- Conventional Dendritic Cell Subsets.
Renan Antonialli, Fernando Bandeira Sulczewski, +7 authors, Silvia Beatriz Boscardin.
Front Immunol, 2017 Dec 20; 8. PMID: 29255470    Free PMC article.
Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells.
Hae-Young Park, Peck S Tan, +9 authors, Mireille H Lahoud.
NPJ Vaccines, 2017 Dec 22; 2. PMID: 29263886    Free PMC article.
Precision-porous templated scaffolds of varying pore size drive dendritic cell activation.
Ruying Chen, Hongyan Ma, Lei Zhang, James D Bryers.
Biotechnol Bioeng, 2017 Dec 28; 115(4). PMID: 29280498    Free PMC article.
Dendritic Cell-Based Cancer Vaccines.
Patricia M Santos, Lisa H Butterfield.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311386    Free PMC article.
Highly Cited. Review.
CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin.
A Flores-Langarica, K Müller Luda, +12 authors, W W Agace.
Mucosal Immunol, 2018 Jan 19; 11(3). PMID: 29346347    Free PMC article.
C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets.
Elise Chiffoleau.
Front Immunol, 2018 Mar 03; 9. PMID: 29497419    Free PMC article.
Review.
Targeted Delivery of Toxoplasma gondii Antigens to Dendritic Cells Promote Immunogenicity and Protective Efficiency against Toxoplasmosis.
Zineb Lakhrif, Alexis Moreau, +6 authors, Nicolas Aubrey.
Front Immunol, 2018 Mar 09; 9. PMID: 29515595    Free PMC article.
Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-Based Adjuvants Including C-Type Lectin Agonists Trehalose Dibehenate or Curdlan.
Maria Vono, Christiane Sigrid Eberhardt, +9 authors, Claire-Anne Siegrist.
Front Immunol, 2018 Mar 16; 9. PMID: 29541075    Free PMC article.
Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.
Taylor T Chrisikos, Yifan Zhou, +3 authors, Haiyan S Li.
Mol Immunol, 2018 Mar 20; 110. PMID: 29549977    Free PMC article.
Review.
The enhanced antitumor-specific immune response with mannose- and CpG-ODN-coated liposomes delivering TRP2 peptide.
Chunhui Lai, Siliang Duan, +9 authors, Xiaoling Lu.
Theranostics, 2018 Mar 21; 8(6). PMID: 29556352    Free PMC article.
Enteric Virome Sensing-Its Role in Intestinal Homeostasis and Immunity.
Rebecca N Metzger, Anne B Krug, Katharina Eisenächer.
Viruses, 2018 Mar 24; 10(4). PMID: 29570694    Free PMC article.
Review.
Dysfunction of antigen processing and presentation by dendritic cells in cancer.
Joanna Bandola-Simon, Paul A Roche.
Mol Immunol, 2018 Apr 10; 113. PMID: 29628265    Free PMC article.
Review.
The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer.
Lorea Villanueva, Leyre Silva, +9 authors, Pablo Sarobe.
Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632721    Free PMC article.
DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice.
Jimmy Jianheng Zhou, Yuan Min Wang, +8 authors, Anne M Durkan.
PLoS One, 2018 Apr 12; 13(4). PMID: 29641559    Free PMC article.
Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses.
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