In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination

Laura C Bonifaz ¹, David P Bonnyay , Anna Charalambous , Dara I Darguste , Shin-Ichiro Fujii , Helena Soares , Marie K Brimnes , Bruno Moltedo , Thomas M Moran , Ralph M Steinman

Affiliations

¹ Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA.

PMID: 15024047
42 References
375 citations

Abstract

The prevention and treatment of prevalent infectious diseases and tumors should benefit from improvements in the induction of antigen-specific T cell immunity. To assess the potential of antigen targeting to dendritic cells to improve immunity, we incorporated ovalbumin protein into a monoclonal antibody to the DEC-205 receptor, an endocytic receptor that is abundant on these cells in lymphoid tissues. Simultaneously, we injected agonistic alpha-CD40 antibody to mature the dendritic cells. We found that a single low dose of antibody-conjugated ovalbumin initiated immunity from the naive CD4+ and CD8+ T cell repertoire. Unexpectedly, the alphaDEC-205 antigen conjugates, given s.c., targeted to dendritic cells systemically and for long periods, and ovalbumin peptide was presented on MHC class I for 2 weeks. This was associated with stronger CD8+ T cell-mediated immunity relative to other forms of antigen delivery, even when the latter was given at a thousand times higher doses. In parallel, the mice showed enhanced resistance to an established rapidly growing tumor and to viral infection at a mucosal site. By better harnessing the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models.

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The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells. Karine Crozat, Rachel Guiton, +11 authors, Marc Dalod. less J Exp Med, 2010 May 19; 207(6). PMID: 20479118 Free PMC article. Highly Cited.
Dendritic cell subsets as vectors and targets for improved cancer therapy. Karolina Palucka, Hideki Ueno, +2 authors, Lee Roberts, Joseph Fay, Jacques Banchereau. less Curr Top Microbiol Immunol, 2010 May 22; 344. PMID: 20490776 Free PMC article. Review.
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Eynav Klechevsky, Anne-Laure Flamar, +11 authors, Jacques Banchereau. less Blood, 2010 Jun 10; 116(10). PMID: 20530286 Free PMC article. Highly Cited.
CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells. Alice W Yewdall, Scott B Drutman, +2 authors, Felecia Jinwala, Keith S Bahjat, Nina Bhardwaj. less PLoS One, 2010 Jun 30; 5(6). PMID: 20585396 Free PMC article.
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody. Cheolho Cheong, Jae-Hoon Choi, +13 authors, Chae Gyu Park. less Blood, 2010 Jul 30; 116(19). PMID: 20668230 Free PMC article.
Dendritic cells: are they clinically relevant? Karolina Palucka, Hideki Ueno, +2 authors, Lee Roberts, Joseph Fay, Jacques Banchereau. less Cancer J, 2010 Aug 10; 16(4). PMID: 20693842 Free PMC article. Review.
The expanding family of dendritic cell subsets. Hideki Ueno, A Karolina Palucka, Jacques Banchereau. Nat Biotechnol, 2010 Aug 11; 28(8). PMID: 20697407
Dendritic cell-specific antigen delivery by coronavirus vaccine vectors induces long-lasting protective antiviral and antitumor immunity. Luisa Cervantes-Barragan, Roland Züst, +8 authors, Volker Thiel. less mBio, 2010 Sep 17; 1(4). PMID: 20844609 Free PMC article.
Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates. Kavita Tewari, Barbara J Flynn, +10 authors, Robert A Seder. less Vaccine, 2010 Sep 18; 28(45). PMID: 20846528 Free PMC article.
Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy. Melissa Swiecki, Marco Colonna. Eur J Immunol, 2010 Sep 21; 40(8). PMID: 20853492 Free PMC article.
Inhibitory C-type lectin receptors in myeloid cells. Pierre Redelinghuys, Gordon D Brown. Immunol Lett, 2010 Oct 12; 136(1). PMID: 20934454 Free PMC article. Review.
From vaccines to memory and back. Federica Sallusto, Antonio Lanzavecchia, Koichi Araki, Rafi Ahmed. Immunity, 2010 Oct 30; 33(4). PMID: 21029957 Free PMC article. Highly Cited. Review.
Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. Rachel S Friedman, Peter Beemiller, +2 authors, Caitlin M Sorensen, Jordan Jacobelli, Matthew F Krummel. less J Exp Med, 2010 Nov 03; 207(12). PMID: 21041455 Free PMC article.
The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs. Shannon J Turley, Anne L Fletcher, Kutlu G Elpek. Nat Rev Immunol, 2010 Nov 20; 10(12). PMID: 21088682 Review.
Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes. Benjamin G Keselowsky, Chang Qing Xia, Michael Clare-Salzler. Hum Vaccin, 2010 Dec 16; 7(1). PMID: 21157186 Free PMC article. Review.
DAI (DLM-1/ZBP1) as a genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity. Alvaro Lladser, Dimitrios Mougiakakos, +4 authors, Karl Ljungberg. less Mol Ther, 2010 Dec 16; 19(3). PMID: 21157438 Free PMC article.
Dendritic cells and immunity against cancer. K Palucka, H Ueno, J Fay, J Banchereau. J Intern Med, 2010 Dec 17; 269(1). PMID: 21158979 Free PMC article. Review.
Targeting skin dendritic cells to improve intradermal vaccination. N Romani, V Flacher, +3 authors, C H Tripp, F Sparber, S Ebner, P Stoitzner. less Curr Top Microbiol Immunol, 2011 Jan 22; 351. PMID: 21253784 Free PMC article. Review.
The impact of nanoparticle ligand density on dendritic-cell targeted vaccines. Arunima Bandyopadhyay, Rebecca L Fine, +2 authors, Stacey Demento, Linda K Bockenstedt, Tarek M Fahmy. less Biomaterials, 2011 Jan 26; 32(11). PMID: 21262534 Free PMC article.
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Juliana Idoyaga, Ashira Lubkin, +8 authors, Ralph M Steinman. less Proc Natl Acad Sci U S A, 2011 Jan 26; 108(6). PMID: 21262813 Free PMC article. Highly Cited.
Targeting human dendritic cell subsets for improved vaccines. Hideki Ueno, Eynav Klechevsky, +7 authors, Sangkon Oh. less Semin Immunol, 2011 Feb 01; 23(1). PMID: 21277223 Free PMC article. Review.
A novel modular antigen delivery system for immuno targeting of human 6-sulfo LacNAc-positive blood dendritic cells (SlanDCs). Claudia C Bippes, Anja Feldmann, +12 authors, Michael Bachmann. less PLoS One, 2011 Feb 02; 6(1). PMID: 21283706 Free PMC article.
Harnessing dendritic cells in inflammatory skin diseases. Chung-Ching Chu, Paola Di Meglio, Frank O Nestle. Semin Immunol, 2011 Feb 08; 23(1). PMID: 21295490 Free PMC article. Review.
Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. Troels R Petersen, Dianne Sika-Paotonu, +2 authors, Deborah A Knight, Helen M A Simkins, Ian F Hermans. less PLoS One, 2011 Apr 13; 6(3). PMID: 21483862 Free PMC article.
Immunogenicity of protein therapeutics: The key causes, consequences and challenges. Matthew P Baker, Helen M Reynolds, Brooke Lumicisi, Christine J Bryson. Self Nonself, 2011 Apr 14; 1(4). PMID: 21487506 Free PMC article. Highly Cited.
Dendritic cell control of tolerogenic responses. Santhakumar Manicassamy, Bali Pulendran. Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488899 Free PMC article. Highly Cited. Review.
Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks? Slobodan Culina, Christian Boitard, Roberto Mallone. Clin Dev Immunol, 2011 Jun 08; 2011. PMID: 21647401 Free PMC article.
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells. Mark Melchers, Katie Matthews, +8 authors, Rogier W Sanders. less Retrovirology, 2011 Jun 22; 8. PMID: 21689404 Free PMC article.
A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies. Jennifer Carlring, Evy De Leenheer, Andrew William Heath. PLoS One, 2011 Aug 04; 6(7). PMID: 21811628 Free PMC article.
Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Fubin Li, Jeffrey V Ravetch. Science, 2011 Aug 20; 333(6045). PMID: 21852502 Free PMC article. Highly Cited.
Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Ning Li, Catherine Matte-Martone, +8 authors, Warren D Shlomchik. less Blood, 2011 Sep 16; 118(22). PMID: 21917752 Free PMC article.
Dendritic cell and macrophage heterogeneity in vivo. Daigo Hashimoto, Jennifer Miller, Miriam Merad. Immunity, 2011 Sep 29; 35(3). PMID: 21943488 Free PMC article. Highly Cited.
Generation of antibody-producing hybridomas following one single immunization with a targeted DNA vaccine. I Øynebråten, T-O Løvås, K Thompson, B Bogen. Scand J Immunol, 2011 Oct 01; 75(4). PMID: 21955209 Free PMC article.
Targeting mucosal immunity in the battle to develop a mastitis vaccine. Mini Bharathan, Isis K Mullarky. J Mammary Gland Biol Neoplasia, 2011 Oct 05; 16(4). PMID: 21968537 Review.
A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo. Austin Pantel, Cheolho Cheong, +8 authors, M Paula Longhi. less Eur J Immunol, 2011 Oct 18; 42(1). PMID: 22002164 Free PMC article.
Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses. Ondrej Stanek, Irena Linhartova, +2 authors, Laleh Majlessi, Claude Leclerc, Peter Sebo. less Mol Biotechnol, 2011 Oct 19; 51(3). PMID: 22006508
Codelivery of the chemokine CCL3 by an adenovirus-based vaccine improves protection from retrovirus infection. Ruth Lietz, Wibke Bayer, +6 authors, Oliver Wildner. less J Virol, 2011 Nov 18; 86(3). PMID: 22090142 Free PMC article.
Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity. C Trumpfheller, M P Longhi, +5 authors, R M Steinman. less J Intern Med, 2011 Dec 01; 271(2). PMID: 22126373 Free PMC article. Review.
T cells as vehicles for cancer vaccination. Adham S Bear, Conrad R Cruz, Aaron E Foster. J Biomed Biotechnol, 2011 Dec 02; 2011. PMID: 22131805 Free PMC article. Review.
Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome. M Catucci, F Prete, +7 authors, A Villa. less Gene Ther, 2011 Dec 23; 19(12). PMID: 22189416 Free PMC article.
Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein. Hiroaki Hemmi, Neeha Zaidi, +10 authors, Juliana Idoyaga. less J Immunol, 2012 Jan 03; 188(3). PMID: 22210914 Free PMC article.
Signaling by myeloid C-type lectin receptors in immunity and homeostasis. David Sancho, Caetano Reis e Sousa. Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224766 Free PMC article. Highly Cited. Review.
CD40-targeted adenoviral cancer vaccines: the long and winding road to the clinic. Basav N Hangalapura, Laura Timares, +3 authors, Tanja D de Gruijl. less J Gene Med, 2012 Jan 10; 14(6). PMID: 22228547 Free PMC article. Review.
C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses. Lara M Kingeter, Xin Lin. Cell Mol Immunol, 2012 Jan 17; 9(2). PMID: 22246129 Free PMC article. Review.
Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals. Chae Gyu Park, Anthony Rodriguez, +4 authors, Ralph M Steinman. less J Immunol Methods, 2012 Jan 26; 377(1-2). PMID: 22273672 Free PMC article.
Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses. Vincent Flacher, Christoph H Tripp, +5 authors, Nikolaus Romani. less J Immunol, 2012 Feb 01; 188(5). PMID: 22291181 Free PMC article.
DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. Jimmy Jianheng Zhou, Yuan Min Wang, +11 authors, Anne M Durkan. less Int J Clin Exp Med, 2012 Feb 14; 5(1). PMID: 22328945 Free PMC article.
Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein. Dharmendra Raghuwanshi, Vivek Mishra, +2 authors, Dipankar Das, Kamaljit Kaur, Mavanur R Suresh. less Mol Pharm, 2012 Feb 24; 9(4). PMID: 22356166 Free PMC article.
Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice. Bei Wang, Neeha Zaidi, +4 authors, Ralph M Steinman. less Breast Cancer Res, 2012 Mar 09; 14(2). PMID: 22397502 Free PMC article.
Beyond empiricism: informing vaccine development through innate immunity research. Stuart M Levitz, Douglas T Golenbock. Cell, 2012 Mar 20; 148(6). PMID: 22424235 Free PMC article. Review.
Cancer immunotherapy via dendritic cells. Karolina Palucka, Jacques Banchereau. Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871 Free PMC article. Highly Cited. Review.
Inflammatory spleen monocytes can upregulate CD11c expression without converting into dendritic cells. Scott B Drutman, Julia C Kendall, E Sergio Trombetta. J Immunol, 2012 Mar 24; 188(8). PMID: 22442444 Free PMC article.
Cross-presentation: how to get there - or how to get the ER. Christoph Kreer, Judith Rauen, Matthias Zehner, Sven Burgdorf. Front Immunol, 2011 Jan 01; 2. PMID: 22566876 Free PMC article.
Targeting Dendritic Cells in vivo for Cancer Therapy. Irina Caminschi, Eugene Maraskovsky, William Ross Heath. Front Immunol, 2012 May 09; 3. PMID: 22566899 Free PMC article.
PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines. Bingbing Dai, Liang Xiao, +2 authors, Paul D Bryson, Jinxu Fang, Pin Wang. less Mol Ther, 2012 May 17; 20(9). PMID: 22588271 Free PMC article.
Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques. Matthias Tenbusch, Ralf Ignatius, +10 authors, Klaus Uberla. less PLoS One, 2012 Jun 22; 7(6). PMID: 22720025 Free PMC article.
Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer. Evelyne Béraud, Aurélie Collignon, +3 authors, Eric Mas. less Oncoimmunology, 2012 Jun 22; 1(1). PMID: 22720212 Free PMC article.
Human macrophages and dendritic cells can equally present MART-1 antigen to CD8(+) T cells after phagocytosis of gamma-irradiated melanoma cells. María Marcela Barrio, Riad Abes, +7 authors, Jean-Luc Teillaud. less PLoS One, 2012 Jul 07; 7(7). PMID: 22768350 Free PMC article.
Cross-presentation by dendritic cells. Olivier P Joffre, Elodie Segura, Ariel Savina, Sebastian Amigorena. Nat Rev Immunol, 2012 Jul 14; 12(8). PMID: 22790179 Highly Cited. Review.
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Muzlifah Haniffa, Amanda Shin, +25 authors, Florent Ginhoux. less Immunity, 2012 Jul 17; 37(1). PMID: 22795876 Free PMC article. Highly Cited.
Microparticle surface modifications targeting dendritic cells for non-activating applications. Jamal S Lewis, Toral D Zaveri, Charles P Crooks, Benjamin G Keselowsky. Biomaterials, 2012 Jul 17; 33(29). PMID: 22796161 Free PMC article.
Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity. Martin Kreutz, Benoit Giquel, +5 authors, Sandra S Diebold. less PLoS One, 2012 Jul 19; 7(7). PMID: 22808118 Free PMC article.
CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation. Nicole M Beauchamp, Rama D Yammani, Martha A Alexander-Miller. J Virol, 2012 Jul 20; 86(19). PMID: 22811544 Free PMC article.
Characterization of epitope-tagged foot-and-mouth disease virus. Julian Seago, Terry Jackson, +5 authors, Nicholas Juleff. less J Gen Virol, 2012 Jul 21; 93(Pt 11). PMID: 22815275 Free PMC article.
Cross-presentation of IgG-containing immune complexes. Kristi Baker, Timo Rath, +2 authors, Wayne I Lencer, Edda Fiebiger, Richard S Blumberg. less Cell Mol Life Sci, 2012 Aug 01; 70(8). PMID: 22847331 Free PMC article. Review.
Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials. Aurélie Moreau, Emilie Varey, +4 authors, Maria-Cristina Cuturi. less Front Immunol, 2012 Aug 22; 3. PMID: 22908013 Free PMC article.
The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells. Carlo Manzo, Juan A Torreno-Pina, +6 authors, Alessandra Cambi. less J Biol Chem, 2012 Sep 29; 287(46). PMID: 23019323 Free PMC article.
Dendritic cell-based vaccines: barriers and opportunities. Jessica A Cintolo, Jashodeep Datta, Sarah J Mathew, Brian J Czerniecki. Future Oncol, 2012 Nov 08; 8(10). PMID: 23130928 Free PMC article. Review.
Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: a novel tool for specific immunotherapy. Esther E Weinberger, Martin Himly, +6 authors, Richard Weiss. less J Control Release, 2012 Nov 14; 165(2). PMID: 23147517 Free PMC article.
An anti-nucleic acid antibody delivers antigen to the cross-presentation pathway in dendritic cells and potentiates therapeutic antitumor effects. Chuong D Pham, Min-Yeong Woo, +2 authors, Yong-Sung Kim, Sun Park, Myung-Hee Kwon. less J Immunol, 2012 Nov 16; 189(12). PMID: 23152565 Free PMC article.
Trial watch: Dendritic cell-based interventions for cancer therapy. Lorenzo Galluzzi, Laura Senovilla, +7 authors, Guido Kroemer. less Oncoimmunology, 2012 Nov 22; 1(7). PMID: 23170259 Free PMC article. Highly Cited.
Dendritic cells and vaccine design for sexually-transmitted diseases. Dorothee Duluc, Julien Gannevat, +7 authors, Sangkon Oh. less Microb Pathog, 2012 Dec 04; 58. PMID: 23201532 Free PMC article. Review.
Streamlined expressed protein ligation using split inteins. Miquel Vila-Perelló, Zhihua Liu, +3 authors, Tom W Muir. less J Am Chem Soc, 2012 Dec 26; 135(1). PMID: 23265282 Free PMC article.
New generation of dendritic cell vaccines. Kristen J Radford, Irina Caminschi. Hum Vaccin Immunother, 2013 Jan 08; 9(2). PMID: 23291951 Free PMC article. Review.
Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205. Carol S Leung, Michael A Maurer, +6 authors, Christian Münz. less Blood, 2013 Jan 09; 121(9). PMID: 23297134 Free PMC article.
Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes. Lee Kim Swee, Carla P Guimaraes, +3 authors, Hidde L Ploegh. less Proc Natl Acad Sci U S A, 2013 Jan 09; 110(4). PMID: 23297227 Free PMC article.
Pathways of antigen processing. Janice S Blum, Pamela A Wearsch, Peter Cresswell. Annu Rev Immunol, 2013 Jan 10; 31. PMID: 23298205 Free PMC article. Highly Cited. Review.
Specialized role of migratory dendritic cells in peripheral tolerance induction. Juliana Idoyaga, Christopher Fiorese, +6 authors, Ralph M Steinman. less J Clin Invest, 2013 Jan 10; 123(2). PMID: 23298832 Free PMC article. Highly Cited.
Normal T cell selection occurs in CD205-deficient thymic microenvironments. William E Jenkinson, Kyoko Nakamura, +2 authors, Andrea J White, Eric J Jenkinson, Graham Anderson. less PLoS One, 2013 Jan 10; 7(12). PMID: 23300927 Free PMC article.
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells. Scott Barbuto, Juliana Idoyaga, +4 authors, Tom W Muir. less Nat Chem Biol, 2013 Feb 19; 9(4). PMID: 23416331 Free PMC article.
In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine. Pan Tao, Marthandan Mahalingam, +3 authors, Venigalla B Rao. less Proc Natl Acad Sci U S A, 2013 Mar 27; 110(15). PMID: 23530211 Free PMC article.
Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting. Federico Perche, Vladimir P Torchilin. J Drug Deliv, 2013 Mar 28; 2013. PMID: 23533772 Free PMC article.
Biomimetic antigenic nanoparticles elicit controlled protective immune response to influenza. Dustin P Patterson, Agnieszka Rynda-Apple, +2 authors, Ann L Harmsen, Allen G Harmsen, Trevor Douglas. less ACS Nano, 2013 Apr 02; 7(4). PMID: 23540530 Free PMC article.
Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells. Elodie Segura, Mélanie Durand, Sebastian Amigorena. J Exp Med, 2013 Apr 10; 210(5). PMID: 23569327 Free PMC article. Highly Cited.
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. Diane Tseng, Jens-Peter Volkmer, +8 authors, Irving L Weissman. less Proc Natl Acad Sci U S A, 2013 May 22; 110(27). PMID: 23690610 Free PMC article. Highly Cited.
Skin-resident antigen-presenting cells: instruction manual for vaccine development. Cynthia M Fehres, Juan J Garcia-Vallejo, Wendy W J Unger, Yvette van Kooyk. Front Immunol, 2013 Jun 27; 4. PMID: 23801994 Free PMC article.
Targeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccination. Cathleen Petzold, Sonja Schallenberg, Joel N H Stern, Karsten Kretschmer. Rev Diabet Stud, 2012 Jan 01; 9(4). PMID: 23804268 Free PMC article. Review.
Targeting Leishmania major Antigens to Dendritic Cells In Vivo Induces Protective Immunity. Ines Matos, Olga Mizenina, +2 authors, Ashira Lubkin, Ralph M Steinman, Juliana Idoyaga. less PLoS One, 2013 Jul 11; 8(6). PMID: 23840706 Free PMC article.
Therapeutic cancer vaccines: past, present, and future. Chunqing Guo, Masoud H Manjili, +3 authors, Xiang-Yang Wang. less Adv Cancer Res, 2013 Jul 23; 119. PMID: 23870514 Free PMC article. Highly Cited. Review.
Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challenge. Hugo R Henriques, Eline V Rampazo, +8 authors, Silvia B Boscardin. less PLoS Negl Trop Dis, 2013 Jul 23; 7(7). PMID: 23875054 Free PMC article.
DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice. Jun Cao, Yiqi Jin, +6 authors, Jian Yan. less BMC Immunol, 2013 Aug 15; 14. PMID: 23941509 Free PMC article.
DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1. Gayatri Mukherjee, Ari Geliebter, +6 authors, Teresa P DiLorenzo. less Int Immunol, 2013 Sep 12; 25(11). PMID: 24021877 Free PMC article.
Delivery strategies for novel vaccine formulations. Maria Trovato, Shelly J Krebs, Nancy L Haigwood, Piergiuseppe De Berardinis. World J Virol, 2012 Feb 12; 1(1). PMID: 24175206 Free PMC article.
C-type Lectin Receptors for Tumor Eradication: Future Directions. Ingeborg Streng-Ouwehand, Wendy W J Unger, Yvette Van Kooyk. Cancers (Basel), 2011 Jan 01; 3(3). PMID: 24212951 Free PMC article.
A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation. Ding Zhang, Cai-Feng Chen, +7 authors, You-Wen He. less PLoS One, 2013 Nov 28; 8(11). PMID: 24278299 Free PMC article.
Trial watch: Dendritic cell-based interventions for cancer therapy. Erika Vacchelli, Ilio Vitale, +8 authors, Lorenzo Galluzzi. less Oncoimmunology, 2013 Nov 29; 2(10). PMID: 24286020 Free PMC article. Review.
Combinatorial peptide libraries: mining for cell-binding peptides. Bethany Powell Gray, Kathlynn C Brown. Chem Rev, 2013 Dec 05; 114(2). PMID: 24299061 Free PMC article. Review.
Dendritic cell-targeted approaches to modulate immune dysfunction in the tumor microenvironment. Anne Gallois, Nina Bhardwaj. Front Immunol, 2013 Dec 18; 4. PMID: 24339825 Free PMC article. Review.
Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Semih U Tareen, Brenna Kelley-Clarke, +10 authors, Scott H Robbins. less Mol Ther, 2014 Jan 15; 22(3). PMID: 24419083 Free PMC article.
Human blood dendritic cell subsets exhibit discriminative pattern recognition receptor profiles. Kristina Lundberg, Frida Rydnert, Lennart Greiff, Malin Lindstedt. Immunology, 2014 Jan 22; 142(2). PMID: 24444310 Free PMC article.
Trial Watch: Peptide vaccines in cancer therapy. Fernando Aranda, Erika Vacchelli, +6 authors, Lorenzo Galluzzi. less Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498550 Free PMC article. Review.
A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. Jianping Yuan, Satoshi Kashiwagi, +20 authors, Mark C Poznansky. less J Hematol Oncol, 2014 Feb 26; 7. PMID: 24565018 Free PMC article.
Self-antigen presentation by dendritic cells in autoimmunity. Ann-Katrin Hopp, Anne Rupp, Veronika Lukacs-Kornek. Front Immunol, 2014 Mar 05; 5. PMID: 24592266 Free PMC article. Review.
Mucosal dendritic cells shape mucosal immunity. Sun-Young Chang, Hyun-Jeong Ko, Mi-Na Kweon. Exp Mol Med, 2014 Mar 15; 46. PMID: 24626170 Free PMC article. Review.
Aptamer-targeted antigen delivery. Brian C Wengerter, Joseph A Katakowski, +4 authors, Matthew Levy. less Mol Ther, 2014 Apr 01; 22(7). PMID: 24682172 Free PMC article.
An engineered non-toxic superantigen increases cross presentation of hepatitis B virus nucleocapsids by human dendritic cells. Julie D McIntosh, Kristy Manning, +4 authors, John A Taylor. less PLoS One, 2014 Apr 03; 9(4). PMID: 24690680 Free PMC article.
Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205. Madhav V Dhodapkar, Mario Sznol, +16 authors, Tibor Keler. less Sci Transl Med, 2014 Apr 18; 6(232). PMID: 24739759 Free PMC article. Highly Cited.
Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells. V Cerovic, S A Houston, +10 authors, S W F Milling. less Mucosal Immunol, 2014 May 23; 8(1). PMID: 24850430 Free PMC article.
Vaccine strategies utilizing C-type lectin receptors on dendritic cells in vivo. Chae Gyu Park. Clin Exp Vaccine Res, 2014 Jul 09; 3(2). PMID: 25003088 Free PMC article. Review.
Inflammatory conditions distinctively alter immunological functions of Langerhans-like cells and dendritic cells in vitro. André Said, Stephanie Bock, Gerrit Müller, Günther Weindl. Immunology, 2014 Jul 26; 144(2). PMID: 25059418 Free PMC article.
Targeting human dendritic cells in situ to improve vaccines. Kartik Sehgal, Kavita M Dhodapkar, Madhav V Dhodapkar. Immunol Lett, 2014 Jul 30; 162(1 Pt A). PMID: 25072116 Free PMC article. Review.
Current status of cancer immunotherapy. K Kono. J Stem Cells Regen Med, 2014 Jul 31; 10(1). PMID: 25075156 Free PMC article. Review.
Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance. Vincent Flacher, Christoph H Tripp, +4 authors, Nikolaus Romani. less EMBO Mol Med, 2014 Aug 03; 6(9). PMID: 25085878 Free PMC article.
The Role of FcRn in Antigen Presentation. Kristi Baker, Timo Rath, Michal Pyzik, Richard S Blumberg. Front Immunol, 2014 Sep 16; 5. PMID: 25221553 Free PMC article. Review.
Targeting DNA vaccines to myeloid cells using a small peptide. Chunting Ye, Jang Gi Choi, +2 authors, Sojan Abraham, Premlata Shankar, N Manjunath. less Eur J Immunol, 2014 Oct 02; 45(1). PMID: 25270431 Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy. Stephanie R Jackson, Jinyun Yuan, Ryan M Teague. Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416 Free PMC article. Review.
In vivo mechanisms involved in enhanced protection utilizing an Fc receptor-targeted mucosal vaccine platform in a bacterial vaccine and challenge model. Constantine Bitsaktsis, Zulfia Babadjanova, Edmund J Gosselin. Infect Immun, 2014 Oct 15; 83(1). PMID: 25312957 Free PMC article.
Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine. Li-Zhen He, Jeffrey Weidlick, +2 authors, Crystal Sisson, Henry C Marsh, Tibor Keler. less Cell Mol Immunol, 2014 Oct 28; 12(6). PMID: 25345808 Free PMC article.
Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders. Leonie Hussaarts, Maria Yazdanbakhsh, Bruno Guigas. Front Immunol, 2014 Nov 05; 5. PMID: 25368615 Free PMC article. Review.
Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen. Sandeep S Saluja, Douglas J Hanlon, +6 authors, Richard L Edelson. less Int J Nanomedicine, 2014 Nov 25; 9. PMID: 25419128 Free PMC article.
A novel method for synthetic vaccine construction based on protein assembly. Zhida Liu, Hang Zhou, +3 authors, Wenjun Wang, Wenjie Tan, Yang-Xin Fu, Mingzhao Zhu. less Sci Rep, 2014 Dec 02; 4. PMID: 25434527 Free PMC article.
Engineering better immunotherapies via RNA interference. Mouldy Sioud. Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483669 Free PMC article. Review.
Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses. Henrike Veninga, Ellen G F Borg, +6 authors, Joke M M den Haan. less Eur J Immunol, 2014 Dec 10; 45(3). PMID: 25487358 Free PMC article.
Targeting Dendritic Cells as a Good Alternative to Combat Leishmania spp. Rafael Freitas-Silva, Maria Carolina Accioly Brelaz-de-Castro, Antônio Mauro Rezende, Valéria Rêgo Pereira. Front Immunol, 2014 Dec 17; 5. PMID: 25505469 Free PMC article. Review.
Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments. Dorothée Duluc, Romain Banchereau, +12 authors, SangKon Oh. less Genome Med, 2014 Dec 19; 6(11). PMID: 25520755 Free PMC article.
Past, present and future targets for immunotherapy in ovarian cancer. Carlton L Schwab, Diana P English, +2 authors, Dana M Roque, Monica Pasternak, Alessandro D Santin. less Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524384 Free PMC article. Review.
Classification of current anticancer immunotherapies. Lorenzo Galluzzi, Erika Vacchelli, +85 authors, Guido Kroemer. less Oncotarget, 2014 Dec 30; 5(24). PMID: 25537519 Free PMC article. Highly Cited. Review.
Virological and preclinical characterization of a dendritic cell targeting, integration-deficient lentiviral vector for cancer immunotherapy. Jared M Odegard, Brenna Kelley-Clarke, +10 authors, Scott H Robbins. less J Immunother, 2015 Feb 07; 38(2). PMID: 25658613 Free PMC article.
Antigen targeting to dendritic cells allows the identification of a CD4 T-cell epitope within an immunodominant Trypanosoma cruzi antigen. Eline V Rampazo, Kelly N S Amorim, +3 authors, Silvia B Boscardin. less PLoS One, 2015 Feb 14; 10(2). PMID: 25679777 Free PMC article.
The ins and outs of MHC class II-mediated antigen processing and presentation. Paul A Roche, Kazuyuki Furuta. Nat Rev Immunol, 2015 Feb 28; 15(4). PMID: 25720354 Free PMC article. Highly Cited. Review.
β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10. Chunmei Fu, Xinjun Liang, +7 authors, Aimin Jiang. less Proc Natl Acad Sci U S A, 2015 Mar 03; 112(9). PMID: 25730849 Free PMC article.
Clinical significance of immunotherapy with combined three kinds of cells for operable colorectal cancer. Xiao-Hui Du, Hai-Liang Liu, +7 authors, Ying-Xin Xu. less Tumour Biol, 2015 Mar 13; 36(7). PMID: 25764087
Optimization of multi-epitopic HIV-1 recombinant protein expression in prokaryote system and conjugation to mouse DEC-205 monoclonal antibody: implication for in-vivo targeted delivery of dendritic cells. Roghayeh Rahimi, Massoumeh Ebtekar, +2 authors, Mehdi Mahdavi. less Iran J Basic Med Sci, 2015 Mar 27; 18(2). PMID: 25810888 Free PMC article.
DNA vaccines encoding DEC205-targeted antigens: immunity or tolerance? Thomas Niezold, Michael Storcksdieck Genannt Bonsmann, +8 authors, Matthias Tenbusch. less Immunology, 2015 Mar 31; 145(4). PMID: 25819746 Free PMC article.
Guiding principles in the design of molecular bioconjugates for vaccine applications. Haipeng Liu, Darrell J Irvine. Bioconjug Chem, 2015 Mar 31; 26(5). PMID: 25822926 Free PMC article. Review.
Antigen delivery by filamentous bacteriophage fd displaying an anti-DEC-205 single-chain variable fragment confers adjuvanticity by triggering a TLR9-mediated immune response. Rossella Sartorius, Luciana D'Apice, +9 authors, Piergiuseppe De Berardinis. less EMBO Mol Med, 2015 Apr 19; 7(7). PMID: 25888235 Free PMC article.
A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40. Jingtao Chen, Gerard Zurawski, +8 authors, A Karolina Palucka. less J Hematol Oncol, 2015 Apr 19; 8. PMID: 25888530 Free PMC article.
ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis. Aarón Silva-Sánchez, Selene Meza-Pérez, +7 authors, Leopoldo Flores-Romo. less PLoS One, 2015 Apr 29; 10(4). PMID: 25915045 Free PMC article.
Trial watch: Dendritic cell-based anticancer therapy. Norma Bloy, Jonathan Pol, +11 authors, Lorenzo Galluzzi. less Oncoimmunology, 2015 May 06; 3(11). PMID: 25941593 Free PMC article. Review.
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production. Matías Alejandro Molina, Ailén Magalí Díaz, +8 authors, Marcela Alejandra Manghi. less PLoS One, 2015 May 16; 10(5). PMID: 25978357 Free PMC article.
A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells. Melissa Santone, Susanna Aprea, +10 authors, Ugo D'Oro. less Hum Vaccin Immunother, 2015 May 30; 11(8). PMID: 26024409 Free PMC article.
Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production. Adriana Flores-Langarica, Saeeda Bobat, +10 authors, Adam F Cunningham. less Eur J Immunol, 2015 Jun 04; 45(8). PMID: 26036767 Free PMC article.
pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205. Longxing Cao, Xiangyi Shi, +2 authors, Haishuang Chang, Qinfen Zhang, Yongning He. less Proc Natl Acad Sci U S A, 2015 Jun 04; 112(23). PMID: 26039988 Free PMC article.
Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions. Thien-Phong Vu Manh, Nicolas Bertho, +2 authors, Marc Dalod. less Front Immunol, 2015 Jun 18; 6. PMID: 26082777 Free PMC article. Review.
Trial Watch: Peptide-based anticancer vaccines. Jonathan Pol, Norma Bloy, +8 authors, Lorenzo Galluzzi. less Oncoimmunology, 2015 Jul 03; 4(4). PMID: 26137405 Free PMC article. Review.
A multi-trimeric fusion of CD40L and gp100 tumor antigen activates dendritic cells and enhances survival in a B16-F10 melanoma DNA vaccine model. Sachin Gupta, James M Termini, +5 authors, Geoffrey W Stone. less Vaccine, 2015 Aug 05; 33(38). PMID: 26241951 Free PMC article.
Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo. Anne-Laure Flamar, Vanessa Contreras, +7 authors, Yves Levy. less PLoS One, 2015 Sep 26; 10(9). PMID: 26407317 Free PMC article.
Delivery of siRNAs to Dendritic Cells Using DEC205-Targeted Lipid Nanoparticles to Inhibit Immune Responses. Joseph A Katakowski, Gayatri Mukherjee, +5 authors, Deborah Palliser. less Mol Ther, 2015 Sep 29; 24(1). PMID: 26412590 Free PMC article.
Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells. Cynthia M Fehres, Sanne Duinkerken, +7 authors, Yvette van Kooyk. less Cell Mol Immunol, 2015 Oct 13; 14(4). PMID: 26456691 Free PMC article.
Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy. Jardin Leleux, Alexandra Atalis, Krishnendu Roy. J Control Release, 2015 Oct 23; 219. PMID: 26489733 Free PMC article. Review.
Minor histocompatibility Ags: identification strategies, clinical results and translational perspectives. R Oostvogels, H M Lokhorst, T Mutis. Bone Marrow Transplant, 2015 Oct 27; 51(2). PMID: 26501766 Review.
The Use of Synthetic Carriers in Malaria Vaccine Design. Liam Powles, Sue D Xiang, Cordelia Selomulya, Magdalena Plebanski. Vaccines (Basel), 2015 Nov 04; 3(4). PMID: 26529028 Free PMC article. Review.
Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses. Björn E Clausen, Patrizia Stoitzner. Front Immunol, 2015 Nov 12; 6. PMID: 26557117 Free PMC article. Review.
Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines. Cleo Goyvaerts, Karine Breckpot. J Immunol Res, 2015 Nov 20; 2015. PMID: 26583156 Free PMC article. Review.
Multilayered Graphene Nano-Film for Controlled Protein Delivery by Desired Electro-Stimuli. Moonhyun Choi, Kyung-Geun Kim, +3 authors, Jinkee Hong. less Sci Rep, 2015 Dec 02; 5. PMID: 26621344 Free PMC article.
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Adriana M Mujal, Julia K Gilden, +2 authors, Audrey Gérard, Makoto Kinoshita, Matthew F Krummel. less Nat Immunol, 2015 Dec 23; 17(3). PMID: 26692174 Free PMC article.
A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract. D Ruane, Y Do, +7 authors, S Mehandru. less Mucosal Immunol, 2016 Jan 07; 9(5). PMID: 26732678 Free PMC article.
PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity. A L Silva, P C Soema, +2 authors, B Slütter, F Ossendorp, W Jiskoot. less Hum Vaccin Immunother, 2016 Jan 12; 12(4). PMID: 26752261 Free PMC article. Review.
T Cell Vaccinology: Beyond the Reflection of Infectious Responses. Nathan D Pennock, Justin D Kedl, Ross M Kedl. Trends Immunol, 2016 Feb 03; 37(3). PMID: 26830540 Free PMC article. Review.
Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance. Christopher J Nirschl, Niroshana Anandasabapathy. Hum Vaccin Immunother, 2016 Feb 03; 12(1). PMID: 26836327 Free PMC article. Review.
The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells. Adnen Faddaoui, Magdalena Bachvarova, +8 authors, Dimcho Bachvarov. less Oncotarget, 2016 Feb 13; 7(12). PMID: 26871602 Free PMC article.
Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells. Ingeborg Streng-Ouwehand, Nataschja I Ho, +9 authors, Yvette van Kooyk. less Elife, 2016 Mar 22; 5. PMID: 26999763 Free PMC article.
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies. Christian H K Lehmann, Lukas Heger, +4 authors, Diana Dudziak. less Vaccines (Basel), 2016 Apr 05; 4(2). PMID: 27043640 Free PMC article. Review.
IL-12p40/IL-10 Producing preCD8α/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection. David Torres, Arnaud Köhler, +4 authors, Véronique Flamand. less PLoS Pathog, 2016 Apr 14; 12(4). PMID: 27074026 Free PMC article.
Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells. Wenjie Yin, Laurent Gorvel, +13 authors, SangKon Oh. less EBioMedicine, 2016 Apr 15; 5. PMID: 27077111 Free PMC article.
Targeting dendritic cells: a promising strategy to improve vaccine effectiveness. Christophe Macri, Claire Dumont, Angus Pr Johnston, Justine D Mintern. Clin Transl Immunology, 2016 May 25; 5(3). PMID: 27217957 Free PMC article. Highly Cited. Review.
A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy. Zhongyi Yan, Yahong Wu, +11 authors, Yuanming Qi. less Oncotarget, 2016 Oct 27; 7(26). PMID: 27250027 Free PMC article.
Immunotherapy: Cancer vaccine triggers antiviral-type defences. Jolanda De Vries, Carl Figdor. Nature, 2016 Jun 10; 534(7607). PMID: 27281206
CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells. Qianqian Zhang, Hehua Dai, +6 authors, Fadi G Lakkis. less J Immunol, 2016 Jul 01; 197(4). PMID: 27357151 Free PMC article.
In vitro-activated tumor-specific T lymphocytes prolong the survival of patients with advanced gastric cancer: a retrospective cohort study. Jun Kuai, Fang Yang, +2 authors, Guang-Jun Li, Xiang-Jie Fang, Bao-Qin Gao. less Onco Targets Ther, 2016 Jul 07; 9. PMID: 27382313 Free PMC article.
A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice. Zhida Liu, Hang Zhou, +2 authors, Wenjun Wang, Yang-Xin Fu, Mingzhao Zhu. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471615 Free PMC article.
Advances and challenges: dendritic cell vaccination strategies for glioblastoma. Teilo H Schaller, John H Sampson. Expert Rev Vaccines, 2016 Aug 09; 16(1). PMID: 27500911 Free PMC article. Review.
Immunoregulatory functions of immune complexes in vaccine and therapy. Yu-Mei Wen, Libing Mu, Yan Shi. EMBO Mol Med, 2016 Aug 31; 8(10). PMID: 27572622 Free PMC article. Review.
T-Regulatory Cells and Vaccination "Pay Attention and Do Not Neglect Them": Lessons from HIV and Cancer Vaccine Trials. Vedran Brezar, Véronique Godot, +3 authors, Liang Cheng, Lishan Su, Yves Lévy, Nabila Seddiki. less Vaccines (Basel), 2016 Sep 09; 4(3). PMID: 27608046 Free PMC article. Review.
Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition. Kirsteen M Tullett, Ingrid M Leal Rojas, +8 authors, Kristen J Radford. less JCI Insight, 2016 Oct 05; 1(7). PMID: 27699265 Free PMC article.
Role of heterogeneous cell population on modulation of dendritic cell phenotype and activation of CD8 T cells for use in cell-based immunotherapies. Hannah Frizzell, Jaehyung Park, Natacha Comandante Lou, Kim A Woodrow. Cell Immunol, 2016 Oct 30; 311. PMID: 27793335 Free PMC article.
Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs. Joao N Duarte, Juan J Cragnolini, +8 authors, Hidde L Ploegh. less J Immunol, 2016 Nov 09; 197(12). PMID: 27821668 Free PMC article.
Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205. Longxing Cao, Haishuang Chang, +2 authors, Xiangyi Shi, Chao Peng, Yongning He. less Proc Natl Acad Sci U S A, 2016 Nov 09; 113(47). PMID: 27821726 Free PMC article.
The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells. Kelly N S Amorim, Eline V Rampazo, +4 authors, Silvia B Boscardin. less Sci Rep, 2016 Dec 22; 6. PMID: 28000705 Free PMC article.
Characterization of a Broadly Reactive Anti-CD40 Agonistic Monoclonal Antibody for Potential Use as an Adjuvant. Cameron Martin, Suryakant D Waghela, +9 authors, Waithaka Mwangi. less PLoS One, 2017 Jan 21; 12(1). PMID: 28107431 Free PMC article.
Dendritic cell targeting vaccine for HPV-associated cancer. Wenjie Yin, Dorothée Duluc, HyeMee Joo, SangKon Oh. Cancer Cell Microenviron, 2017 Jan 31; 3(4). PMID: 28133621 Free PMC article.
Dendritic Cells Cross-Present Immunogenic Lentivector-Encoded Antigen from Transduced Cells to Prime Functional T Cell Immunity. Alastair Hotblack, Sara Seshadri, +4 authors, Clare L Bennett. less Mol Ther, 2017 Feb 06; 25(2). PMID: 28153097 Free PMC article.
CIITA-driven MHC class II expressing tumor cells can efficiently prime naive CD4+ TH cells in vivo and vaccinate the host against parental MHC-II-negative tumor cells. Farah Bou Nasser Eddine, Greta Forlani, +3 authors, Roberto S Accolla. less Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197387 Free PMC article.
Dendritic Cell Targeting Effectively Boosts T Cell Responses Elicited by an HIV Multiepitope DNA Vaccine. Juliana de Souza Apostólico, Victória Alves Santos Lunardelli, +4 authors, Daniela Santoro Rosa. less Front Immunol, 2017 Feb 23; 8. PMID: 28223987 Free PMC article.
Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver. Julia Volckmar, Marcus Gereke, +11 authors, Dunja Bruder. less Sci Rep, 2017 Mar 08; 7. PMID: 28266658 Free PMC article.
Influence of protein fold stability on immunogenicity and its implications for vaccine design. Sandra Scheiblhofer, Josef Laimer, +2 authors, Yoan Machado, Richard Weiss, Josef Thalhamer. less Expert Rev Vaccines, 2017 Mar 16; 16(5). PMID: 28290225 Free PMC article. Review.
Transmembrane TNF-dependent uptake of anti-TNF antibodies. Arun Deora, Subramanya Hegde, +15 authors, Tariq Ghayur. less MAbs, 2017 Mar 23; 9(4). PMID: 28323513 Free PMC article.
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo. Christian H K Lehmann, Anna Baranska, +15 authors, Diana Dudziak. less J Exp Med, 2017 Apr 09; 214(5). PMID: 28389502 Free PMC article.
Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia. Xiufen Chen, Dominick Fosco, Douglas E Kline, Justin Kline. Oncoimmunology, 2017 May 17; 6(4). PMID: 28507789 Free PMC article.
Primary Human Blood Dendritic Cells for Cancer Immunotherapy-Tailoring the Immune Response by Dendritic Cell Maturation. Simone P Sittig, I Jolanda M de Vries, Gerty Schreibelt. Biomedicines, 2015 Dec 02; 3(4). PMID: 28536413 Free PMC article. Review.
IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Christopher J Nirschl, Mayte Suárez-Fariñas, +26 authors, Niroshana Anandasabapathy. less Cell, 2017 Jul 01; 170(1). PMID: 28666115 Free PMC article. Highly Cited.
Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines. Dieke van Dinther, Dorian A Stolk, +3 authors, Joke M M den Haan. less J Leukoc Biol, 2017 Jul 22; 102(4). PMID: 28729358 Free PMC article. Review.
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin. Charlotte Deloizy, Even Fossum, +16 authors, Isabelle Schwartz-Cornil. less Sci Rep, 2017 Aug 11; 7(1). PMID: 28794452 Free PMC article.
Trial watch: Dendritic cell-based anticancer immunotherapy. Abhishek D Garg, Monica Vara Perez, +4 authors, Lorenzo Galluzzi. less Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811970 Free PMC article. Highly Cited. Review.
Nanomaterials for cancer immunotherapy. Wantong Song, Sara N Musetti, Leaf Huang. Biomaterials, 2017 Sep 30; 148. PMID: 28961532 Free PMC article. Review.
Dendritic cell targeted HIV-1 gag protein vaccine provides help to a recombinant Newcastle disease virus vectored vaccine including mobilization of protective CD8+ T cells. Loveline N Ngu, Nadesh N Nji, +17 authors, Godwin W Nchinda. less Immun Inflamm Dis, 2017 Dec 06; 6(1). PMID: 29205929 Free PMC article.
Towards personalized, tumour-specific, therapeutic vaccines for cancer. Zhuting Hu, Patrick A Ott, Catherine J Wu. Nat Rev Immunol, 2017 Dec 12; 18(3). PMID: 29226910 Free PMC article. Highly Cited. Review.
Immunotherapy in ovarian cancer. K Odunsi. Ann Oncol, 2017 Dec 13; 28(suppl_8). PMID: 29232467 Free PMC article. Review.
CpG Oligodeoxinucleotides and Flagellin Modulate the Immune Response to Antigens Targeted to CD8α+ and CD8α- Conventional Dendritic Cell Subsets. Renan Antonialli, Fernando Bandeira Sulczewski, +7 authors, Silvia Beatriz Boscardin. less Front Immunol, 2017 Dec 20; 8. PMID: 29255470 Free PMC article.
Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells. Hae-Young Park, Peck S Tan, +9 authors, Mireille H Lahoud. less NPJ Vaccines, 2017 Dec 22; 2. PMID: 29263886 Free PMC article.
Precision-porous templated scaffolds of varying pore size drive dendritic cell activation. Ruying Chen, Hongyan Ma, Lei Zhang, James D Bryers. Biotechnol Bioeng, 2017 Dec 28; 115(4). PMID: 29280498 Free PMC article.
Dendritic Cell-Based Cancer Vaccines. Patricia M Santos, Lisa H Butterfield. J Immunol, 2018 Jan 10; 200(2). PMID: 29311386 Free PMC article. Highly Cited. Review.
CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin. A Flores-Langarica, K Müller Luda, +12 authors, W W Agace. less Mucosal Immunol, 2018 Jan 19; 11(3). PMID: 29346347 Free PMC article.
C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets. Elise Chiffoleau. Front Immunol, 2018 Mar 03; 9. PMID: 29497419 Free PMC article. Review.
Targeted Delivery of Toxoplasma gondii Antigens to Dendritic Cells Promote Immunogenicity and Protective Efficiency against Toxoplasmosis. Zineb Lakhrif, Alexis Moreau, +6 authors, Nicolas Aubrey. less Front Immunol, 2018 Mar 09; 9. PMID: 29515595 Free PMC article.
Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-Based Adjuvants Including C-Type Lectin Agonists Trehalose Dibehenate or Curdlan. Maria Vono, Christiane Sigrid Eberhardt, +9 authors, Claire-Anne Siegrist. less Front Immunol, 2018 Mar 16; 9. PMID: 29541075 Free PMC article.
Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer. Taylor T Chrisikos, Yifan Zhou, +3 authors, Haiyan S Li. less Mol Immunol, 2018 Mar 20; 110. PMID: 29549977 Free PMC article. Review.
The enhanced antitumor-specific immune response with mannose- and CpG-ODN-coated liposomes delivering TRP2 peptide. Chunhui Lai, Siliang Duan, +9 authors, Xiaoling Lu. less Theranostics, 2018 Mar 21; 8(6). PMID: 29556352 Free PMC article.
Enteric Virome Sensing-Its Role in Intestinal Homeostasis and Immunity. Rebecca N Metzger, Anne B Krug, Katharina Eisenächer. Viruses, 2018 Mar 24; 10(4). PMID: 29570694 Free PMC article. Review.
Dysfunction of antigen processing and presentation by dendritic cells in cancer. Joanna Bandola-Simon, Paul A Roche. Mol Immunol, 2018 Apr 10; 113. PMID: 29628265 Free PMC article. Review.
The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer. Lorea Villanueva, Leyre Silva, +9 authors, Pablo Sarobe. less Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632721 Free PMC article.
DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice. Jimmy Jianheng Zhou, Yuan Min Wang, +8 authors, Anne M Durkan. less PLoS One, 2018 Apr 12; 13(4). PMID: 29641559 Free PMC article.
Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses. Lis Noelia Velasquez, Philipp Stüve, +10 authors, Luciana Berod. less Front Immunol, 2018 Apr 18; 9. PMID: 29662482 Free PMC article.
CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion. Lukas Heger, Silke Balk, +10 authors, Diana Dudziak. less Front Immunol, 2018 May 15; 9. PMID: 29755453 Free PMC article.
Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses. Andrew W Woodham, Ross W Cheloha, +9 authors, Hidde L Ploegh. less Cancer Immunol Res, 2018 May 25; 6(7). PMID: 29792298 Free PMC article.
Current status of cancer immunotherapy for esophageal squamous cell carcinoma. Koji Kono, Kousaku Mimura, +9 authors, Shinji Ohki. less Esophagus, 2018 Jun 13; 15(1). PMID: 29892809 Review.
Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability. Kelly D Moynihan, Rebecca L Holden, +11 authors, Darrell J Irvine. less Cancer Immunol Res, 2018 Jun 20; 6(9). PMID: 29915023 Free PMC article.
Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines. Laura Gornati, Ivan Zanoni, Francesca Granucci. Front Immunol, 2018 Jul 13; 9. PMID: 29997628 Free PMC article. Review.
An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells. Siyuan Ma, Xiaohua Chen, +6 authors, Zhenghao Tang. less Cell Cycle, 2018 Jul 19; 17(10). PMID: 30019620 Free PMC article.
Immunotherapy for esophageal squamous cell carcinoma: a review. Kosaku Mimura, Leo Yamada, +9 authors, Koji Kono. less Fukushima J Med Sci, 2018 Jul 31; 64(2). PMID: 30058598 Free PMC article. Review.
Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma. Dieke van Dinther, Henrike Veninga, +7 authors, Joke M M den Haan. less Front Immunol, 2018 Sep 22; 9. PMID: 30237798 Free PMC article.
The Nontoxic Cholera B Subunit Is a Potent Adjuvant for Intradermal DC-Targeted Vaccination. Laura Antonio-Herrera, Oscar Badillo-Godinez, +7 authors, Laura C Bonifaz. less Front Immunol, 2018 Oct 16; 9. PMID: 30319653 Free PMC article.
Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination Sophie K Horrevorts, Dorian A Stolk, +12 authors, Yvette van Kooyk. less Cancers (Basel), 2019 Aug 31; 11(9). PMID: 31466401 Free PMC article.
Peptide-Based Vaccination for Antibody Responses Against HIV. Behazine Combadière, Manon Beaujean, Chloé Chaudesaigues, Vincent Vieillard. Vaccines (Basel), 2019 Sep 05; 7(3). PMID: 31480779 Free PMC article. Review.
Trial watch: dendritic cell vaccination for cancer immunotherapy. Jenny Sprooten, Jolien Ceusters, +6 authors, Abhishek D Garg. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646087 Free PMC article. Highly Cited. Review.
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. Andrew D Hughes, Daqiang Zhao, +9 authors, Fadi G Lakkis. less J Clin Invest, 2019 Nov 26; 130(1). PMID: 31763998 Free PMC article.
Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines. Stacey L Demento, Alyssa L Siefert, +2 authors, Arunima Bandyopadhyay, Fiona A Sharp, Tarek M Fahmy. less Trends Biotechnol, 2011 Apr 05; 29(6). PMID: 21459467 Free PMC article. Review.
Novel vaccines: Technology and development. Sarita U Patil, Wayne G Shreffler. J Allergy Clin Immunol, 2018 Jul 05; 143(3). PMID: 29970235 Free PMC article. Review.
Engineering Targeting Materials for Therapeutic Cancer Vaccines. Priscilla S Briquez, Sylvie Hauert, +4 authors, Jeffrey A Hubbell. less Front Bioeng Biotechnol, 2020 Mar 03; 8. PMID: 32117911 Free PMC article. Review.
Dendritic cell targeted Ccl3- and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site. Anna Lysén, Ranveig Braathen, +3 authors, Even Fossum. less Sci Rep, 2019 Feb 14; 9(1). PMID: 30755656 Free PMC article.
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