Journal Article
. 2004 Jun;5(6).
doi: 10.1016/j.ccr.2004.05.015.

A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

Xiao-Jun Ma 1 Zuncai Wang  Paula D Ryan  Steven J Isakoff  Anne Barmettler  Andrew Fuller  Beth Muir  Gayatry Mohapatra  Ranelle Salunga  J Todd Tuggle  Yen Tran  Diem Tran  Ana Tassin  Paul Amon  Wilson Wang  Wei Wang  Edward Enright  Kimberly Stecker  Eden Estepa-Sabal  Barbara Smith  Jerry Younger  Ulysses Balis  James Michaelson  Atul Bhan  Karleen Habin  Thomas M Baer  Joan Brugge  Daniel A Haber  Mark G Erlander  Dennis C Sgroi  
Affiliations
  • PMID: 15193263
  •     301 citations

Abstract

Tamoxifen significantly reduces tumor recurrence in certain patients with early-stage estrogen receptor-positive breast cancer, but markers predictive of treatment failure have not been identified. Here, we generated gene expression profiles of hormone receptor-positive primary breast cancers in a set of 60 patients treated with adjuvant tamoxifen monotherapy. An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed existing biomarkers. Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer. The HOXB13:IL17BR expression ratio may be useful for identifying patients appropriate for alternative therapeutic regimens in early-stage breast cancer.

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Monique Chambon, Béatrice Orsetti, +8 authors, Vincent Cavaillès.
Am J Pathol, 2011 Mar 26; 178(4). PMID: 21435435    Free PMC article.
Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.
Ines Barone, Lauren Brusco, +9 authors, Suzanne A W Fuqua.
J Natl Cancer Inst, 2011 Mar 31; 103(7). PMID: 21447808    Free PMC article.
Design and multiseries validation of a web-based gene expression assay for predicting breast cancer recurrence and patient survival.
Ryan K Van Laar.
J Mol Diagn, 2011 Apr 05; 13(3). PMID: 21458382    Free PMC article.
Somatic mutations in cancer development.
Lucio Luzzatto.
Environ Health, 2011 Apr 16; 10 Suppl 1. PMID: 21489208    Free PMC article.
Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6×FEC versus 3×FEC/3×Docetaxel.
Eva J Kantelhardt, Martina Vetter, +12 authors, Nadia Harbeck.
BMC Cancer, 2011 Apr 19; 11. PMID: 21496284    Free PMC article.
Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection.
Carmen Criscitiello, Debora Fumagalli, Kamal S Saini, Sherene Loi.
Onco Targets Ther, 2011 May 10; 4. PMID: 21552410    Free PMC article.
Prognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial.
P-L Jerevall, X-J Ma, +9 authors, O Stål.
Br J Cancer, 2011 May 12; 104(11). PMID: 21559019    Free PMC article.
The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.
Kideok Jin, Xiangjun Kong, +14 authors, Saraswati Sukumar.
Proc Natl Acad Sci U S A, 2011 Jun 22; 109(8). PMID: 21690342    Free PMC article.
Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction.
Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho.
Breast Cancer Res, 2011 Jul 27; 13(3). PMID: 21787441    Free PMC article.
Review.
Predictive and prognostic molecular markers for cancer medicine.
Sunali Mehta, Andrew Shelling, +4 authors, Cristin Print.
Ther Adv Med Oncol, 2010 Mar 01; 2(2). PMID: 21789130    Free PMC article.
Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response.
Qiyuan Li, Aron C Eklund, +8 authors, Zoltan Szallasi.
BMC Bioinformatics, 2011 Jul 30; 12. PMID: 21798043    Free PMC article.
c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1.
Mario Campone, Bélinda Noël, +12 authors, Philippe Juin.
Mol Cancer, 2011 Sep 09; 10. PMID: 21899728    Free PMC article.
Molecular characterization of the tumor-suppressive function of nischarin in breast cancer.
Somesh Baranwal, Yanfang Wang, +7 authors, Suresh K Alahari.
J Natl Cancer Inst, 2011 Sep 16; 103(20). PMID: 21917605    Free PMC article.
Microarray-based cancer prediction using single genes.
Xiaosheng Wang, Richard Simon.
BMC Bioinformatics, 2011 Oct 11; 12. PMID: 21982331    Free PMC article.
[Research advances of artemin].
Guangsu Xun, Fengjie Guo, Zhigang Li, Qinghua Zhou.
Zhongguo Fei Ai Za Zhi, 2011 Oct 20; 14(10). PMID: 22008109    Free PMC article.
Review.
Invasive Breast Cancer: Recognition of Molecular Subtypes.
Johanna D Strehl, David L Wachter, +2 authors, Arndt Hartmann.
Breast Care (Basel), 2011 Dec 03; 6(4). PMID: 22135623    Free PMC article.
Robust two-gene classifiers for cancer prediction.
Xiaosheng Wang.
Genomics, 2011 Dec 06; 99(2). PMID: 22138042    Free PMC article.
Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.
Lee H Chen, Wen-Hung Kuo, +7 authors, King-Jen Chang.
PLoS One, 2011 Dec 06; 6(11). PMID: 22140552    Free PMC article.
Practical implications of gene-expression-based assays for breast oncologists.
Aleix Prat, Matthew J Ellis, Charles M Perou.
Nat Rev Clin Oncol, 2011 Dec 07; 9(1). PMID: 22143140    Free PMC article.
Highly Cited. Review.
Early developments in gene-expression profiling of breast tumors: potential for increasing black-white patient disparities in breast cancer outcomes?
Donna H Odierna, Aimee Afable-Munsuz, +5 authors, Ninez A Ponce.
Per Med, 2011 Dec 23; 8(6). PMID: 22190978    Free PMC article.
Potential utility of an expression array signature for predicting anthracycline responsiveness or resistance.
Michael F Press, Michael A Gordon, Dennis J Slamon.
J Clin Oncol, 2011 Dec 29; 30(4). PMID: 22203766    Free PMC article.
Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.
Jun Yang, Oliver Staples, +13 authors, Margaret Ashcroft.
J Clin Invest, 2012 Jan 05; 122(2). PMID: 22214851    Free PMC article.
Identification and validation of gene expression models that predict clinical outcome in patients with early-stage laryngeal cancer.
E Fountzilas, K Markou, +8 authors, D Spentzos.
Ann Oncol, 2012 Jan 06; 23(8). PMID: 22219018    Free PMC article.
Association of HADHA expression with the risk of breast cancer: targeted subset analysis and meta-analysis of microarray data.
Manju Mamtani, Hemant Kulkarni.
BMC Res Notes, 2012 Jan 14; 5. PMID: 22240105    Free PMC article.
Evaluation of HOXB13 as a molecular marker of recurrent prostate cancer.
Tae-O Jeong, Kyung-Jin Oh, +5 authors, Chaeyong Jung.
Mol Med Rep, 2012 Feb 02; 5(4). PMID: 22293681    Free PMC article.
Med1 plays a critical role in the development of tamoxifen resistance.
Arumugam Nagalingam, Mourad Tighiouart, +4 authors, Dipali Sharma.
Carcinogenesis, 2012 Feb 22; 33(4). PMID: 22345290    Free PMC article.
A prognostic gene expression profile that predicts circulating tumor cell presence in breast cancer patients.
Timothy J Molloy, Paul Roepman, Bjørn Naume, Laura J van't Veer.
PLoS One, 2012 Mar 03; 7(2). PMID: 22384245    Free PMC article.
Hormonal therapy in breast cancer: a model disease for the personalization of cancer care.
Shannon Puhalla, Saveri Bhattacharya, Nancy E Davidson.
Mol Oncol, 2012 Mar 13; 6(2). PMID: 22406404    Free PMC article.
Review.
Neutropenia Prediction Based on First-Cycle Blood Counts Using a FOS-3NN Classifier.
Elize A Shirdel, Michael J Korenberg, Yolanda Madarnas.
Adv Bioinformatics, 2011 Jan 01; 2011. PMID: 22454638    Free PMC article.
Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer.
Ali Naderi, Michelle Meyer, Dennis H Dowhan.
Neoplasia, 2012 May 12; 14(4). PMID: 22577344    Free PMC article.
Increased HOX C13 expression in metastatic melanoma progression.
Monica Cantile, Giosuè Scognamiglio, +8 authors, Gerardo Botti.
J Transl Med, 2012 May 16; 10. PMID: 22583695    Free PMC article.
A roundabout way to cancer.
Mimmi S Ballard, Lindsay Hinck.
Adv Cancer Res, 2012 May 17; 114. PMID: 22588058    Free PMC article.
Review.
DNA methylation profiling distinguishes three clusters of breast cancer cell lines.
Siyuan Zheng, Zhongming Zhao.
Chem Biodivers, 2012 May 17; 9(5). PMID: 22589087    Free PMC article.
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer.
Ali Naderi, Michelle Meyer.
Breast Cancer Res, 2012 Jul 24; 14(4). PMID: 22817771    Free PMC article.
The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients.
Catharina Medrek, Fredrik Pontén, Karin Jirström, Karin Leandersson.
BMC Cancer, 2012 Jul 25; 12. PMID: 22824040    Free PMC article.
Highly Cited.
Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?
Karin Beelen, Wilbert Zwart, Sabine C Linn.
Nat Rev Clin Oncol, 2012 Jul 25; 9(9). PMID: 22825374
Review.
ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity.
Xinyan Wu, Stephan Ellmann, +8 authors, Saraswati Sukumar.
PLoS One, 2012 Jul 31; 7(7). PMID: 22844406    Free PMC article.
Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-Seq data.
Kathryn J Huber-Keener, Xiuping Liu, +11 authors, Rongling Wu.
PLoS One, 2012 Jul 31; 7(7). PMID: 22844461    Free PMC article.
Association of a HOXB13 variant with breast cancer.
Shaheen Alanee, Fergus Couch, Kenneth Offit.
N Engl J Med, 2012 Aug 03; 367(5). PMID: 22853031    Free PMC article.
Predicting response of bladder cancers to gemcitabine and carboplatin neoadjuvant chemotherapy through genome-wide gene expression profiling.
Yoichiro Kato, Hitoshi Zembutsu, +5 authors, Yusuke Nakamura.
Exp Ther Med, 2011 Jan 01; 2(1). PMID: 22977468    Free PMC article.
Negative regulation of NF-κB by the ING4 tumor suppressor in breast cancer.
Sara A Byron, Elizabeth Min, +6 authors, Suwon Kim.
PLoS One, 2012 Oct 12; 7(10). PMID: 23056468    Free PMC article.
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma.
Kiyoshi Takagi, Takuya Moriya, +12 authors, Takashi Suzuki.
Horm Cancer, 2012 Oct 26; 4(1). PMID: 23096432
The HOXB13 p.Gly84Glu mutation is not associated with the risk of breast cancer.
Mohammad R Akbari, Wojciech Kluźniak, +8 authors, Cezary Cybulski.
Breast Cancer Res Treat, 2012 Oct 27; 136(3). PMID: 23099437    Free PMC article.
Prediction and prognosis: impact of gene expression profiling in personalized treatment of breast cancer patients.
Michael R Mallmann, Andrea Staratschek-Jox, +5 authors, Joachim L Schultze.
EPMA J, 2010 Sep 01; 1(3). PMID: 23199086    Free PMC article.
Transcriptional shift identifies a set of genes driving breast cancer chemoresistance.
Laura Vera-Ramirez, Pedro Sanchez-Rovira, +3 authors, Jose A Lorente.
PLoS One, 2013 Jan 18; 8(1). PMID: 23326553    Free PMC article.
Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study.
Maria B Lyng, Anne-Vibeke Lænkholm, +4 authors, Henrik J Ditzel.
PLoS One, 2013 Jan 24; 8(1). PMID: 23342080    Free PMC article.
PBOV1 is a human de novo gene with tumor-specific expression that is associated with a positive clinical outcome of cancer.
Nikolay Samusik, Larisa Krukovskaya, +2 authors, Andrey P Kozlov.
PLoS One, 2013 Feb 19; 8(2). PMID: 23418531    Free PMC article.
Neoplastic and stromal cells contribute to an extracellular matrix gene expression profile defining a breast cancer subtype likely to progress.
Tiziana Triulzi, Patrizia Casalini, +7 authors, Elda Tagliabue.
PLoS One, 2013 Feb 27; 8(2). PMID: 23441215    Free PMC article.
HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease.
Laurel A Habel, Lori C Sakoda, +6 authors, Charles P Quesenberry.
Breast Cancer Res, 2013 Mar 19; 15(2). PMID: 23497539    Free PMC article.
A prognosis classifier for breast cancer based on conserved gene regulation between mammary gland development and tumorigenesis: a multiscale statistical model.
Yingpu Tian, Baozhen Chen, +2 authors, Zhongxian Lu.
PLoS One, 2013 Apr 09; 8(4). PMID: 23565194    Free PMC article.
Protein tyrosine phosphatase 4A2 expression predicts overall and disease-free survival of human breast cancer and is associated with estrogen and progestin receptor status.
Sarah A Andres, James L Wittliff, Alan Cheng.
Horm Cancer, 2013 Apr 10; 4(4). PMID: 23568563
Identification and validation of a new set of five genes for prediction of risk in early breast cancer.
Giorgio Mustacchi, Maria Pia Sormani, +5 authors, Luca Morandi.
Int J Mol Sci, 2013 May 08; 14(5). PMID: 23648477    Free PMC article.
Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker.
Dennis C Sgroi, Erin Carney, +16 authors, Paul E Goss.
J Natl Cancer Inst, 2013 Jul 03; 105(14). PMID: 23812955    Free PMC article.
Interrogating differences in expression of targeted gene sets to predict breast cancer outcome.
Sarah A Andres, Guy N Brock, James L Wittliff.
BMC Cancer, 2013 Jul 04; 13. PMID: 23819905    Free PMC article.
BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome.
Stephen F Madden, Colin Clarke, +5 authors, William M Gallagher.
Breast Cancer Res, 2013 Jul 04; 15(4). PMID: 23820017    Free PMC article.
Highly Cited.
HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression.
Nilay Shah, Kideok Jin, +12 authors, Saraswati Sukumar.
Cancer Res, 2013 Jul 09; 73(17). PMID: 23832664    Free PMC article.
Yin Yang gene expression ratio signature for lung cancer prognosis.
Wayne Xu, Shantanu Banerji, +3 authors, Robert Kratzke.
PLoS One, 2013 Jul 23; 8(7). PMID: 23874744    Free PMC article.
Aberrant promoter hypermethylation of p21 (WAF1/CIP1) gene and its impact on expression and role of polymorphism in the risk of breast cancer.
Marjan Askari, Ranbir Chander Sobti, Mohsen Nikbakht, Suresh C Sharma.
Mol Cell Biochem, 2013 Sep 06; 382(1-2). PMID: 24005533
Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population.
Dennis C Sgroi, Ivana Sestak, +9 authors, Mitch Dowsett.
Lancet Oncol, 2013 Sep 17; 14(11). PMID: 24035531    Free PMC article.
Highly Cited.
Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers.
Monica Cantile, Giosuè Scognamiglio, +10 authors, Gerardo Botti.
Int J Mol Sci, 2013 Nov 06; 14(11). PMID: 24189220    Free PMC article.
Two-gene expression ratio as predictor for breast cancer treated with tamoxifen: evidence from meta-analysis.
Lin Zhao, Shimiao Zhu, Ying Gao, Yaogang Wang.
Tumour Biol, 2013 Nov 23; 35(4). PMID: 24264313
Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice.
Amy Brock, Silva Krause, +4 authors, Donald E Ingber.
Sci Transl Med, 2014 Jan 03; 6(217). PMID: 24382894    Free PMC article.
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients.
Anna Tessari, Dario Palmieri, Serena Di Cosimo.
Pharmgenomics Pers Med, 2014 Jan 10; 7. PMID: 24403841    Free PMC article.
Review.
Molecular tests as prognostic factors in breast cancer.
Marc J van de Vijver.
Virchows Arch, 2014 Feb 04; 464(3). PMID: 24487789
Review.
CCNA2 is a prognostic biomarker for ER+ breast cancer and tamoxifen resistance.
Tian Gao, Yong Han, +3 authors, Jiafu Ji.
PLoS One, 2014 Mar 14; 9(3). PMID: 24622579    Free PMC article.
A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.
Ryan P McMullin, Ben S Wittner, +11 authors, Dennis C Sgroi.
Breast Cancer Res, 2014 Mar 15; 16(2). PMID: 24625110    Free PMC article.
Identification of phenotype deterministic genes using systemic analysis of transcriptional response.
Jungsul Lee, Junseong Park, Chulhee Choi.
Sci Rep, 2014 Mar 20; 4. PMID: 24642983    Free PMC article.
Identification of Marker Genes for Cancer Based on Microarrays Using a Computational Biology Approach.
Xiaosheng Wang.
Curr Bioinform, 2014 Apr 01; 9(2). PMID: 24683388    Free PMC article.
ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer.
Mary M Heckler, Hemang Thakor, Cara C Schafer, Rebecca B Riggins.
FEBS J, 2014 Apr 02; 281(10). PMID: 24684682    Free PMC article.
Loss of B-cell translocation gene 2 expression in estrogen receptor-positive breast cancer predicts tamoxifen resistance.
Maiko Takahashi, Tetsu Hayashida, +3 authors, Yuko Kitagawa.
Cancer Sci, 2014 Apr 05; 105(6). PMID: 24698107    Free PMC article.
Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.
F Al-Ejeh, P T Simpson, +12 authors, K K Khanna.
Oncogenesis, 2014 Apr 23; 3. PMID: 24752235    Free PMC article.
Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer.
Sarah E Holton, Anna Bergamaschi, Benita S Katzenellenbogen, Rohit Bhargava.
PLoS One, 2014 May 13; 9(5). PMID: 24816718    Free PMC article.
A 41-gene signature derived from breast cancer stem cells as a predictor of survival.
Zhi-Qiang Yin, Jian-Jun Liu, +9 authors, Hong-Xia Wang.
J Exp Clin Cancer Res, 2014 Jun 08; 33. PMID: 24906694    Free PMC article.
Breast Cancer Survival Defined by the ER/PR/HER2 Subtypes and a Surrogate Classification according to Tumor Grade and Immunohistochemical Biomarkers.
Carol A Parise, Vincent Caggiano.
J Cancer Epidemiol, 2014 Jun 24; 2014. PMID: 24955090    Free PMC article.
Highly Cited.
HOX genes and their role in the development of human cancers.
Seema Bhatlekar, Jeremy Z Fields, Bruce M Boman.
J Mol Med (Berl), 2014 Jul 06; 92(8). PMID: 24996520
Highly Cited. Review.
Evaluation of the ability of adjuvant tamoxifen-benefit gene signatures to predict outcome of hormone-naive estrogen receptor-positive breast cancer patients treated with tamoxifen in the advanced setting.
Anieta M Sieuwerts, Maria B Lyng, +6 authors, Henrik J Ditzel.
Mol Oncol, 2014 Aug 02; 8(8). PMID: 25081647    Free PMC article.
Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.
Ania W Payne, Dhruv K Pant, Tien-Chi Pan, Lewis A Chodosh.
Cancer Res, 2014 Aug 29; 74(21). PMID: 25164007    Free PMC article.
Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer.
Brennan Decker, Elaine A Ostrander.
Pharmgenomics Pers Med, 2014 Sep 11; 7. PMID: 25206306    Free PMC article.
Review.
FLI1 expression is correlated with breast cancer cellular growth, migration, and invasion and altered gene expression.
Melissa N Scheiber, Patricia M Watson, +5 authors, Dennis K Watson.
Neoplasia, 2014 Nov 08; 16(10). PMID: 25379017    Free PMC article.
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Sungwoo Park, Seon-Guk Choi, +2 authors, Yong-Keun Jung.
Autophagy, 2014 Dec 09; 10(11). PMID: 25483962    Free PMC article.
Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes.
Jimin Guo, Lucie Canaff, +8 authors, Jean-Jacques Lebrun.
Breast Cancer Res, 2014 Dec 17; 16(6). PMID: 25499443    Free PMC article.
BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.
Walid T Khaled, Song Choon Lee, +15 authors, Pentao Liu.
Nat Commun, 2015 Jan 13; 6. PMID: 25574598    Free PMC article.
Highly Cited.
Network-based approach to identify prognostic biomarkers for estrogen receptor-positive breast cancer treatment with tamoxifen.
Rong Liu, Cheng-Xian Guo, Hong-Hao Zhou.
Cancer Biol Ther, 2015 Mar 11; 16(2). PMID: 25756514    Free PMC article.
Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease.
Maurice P H M Jansen, Leen Sas, +20 authors, Steven Van Laere.
Mol Oncol, 2015 Mar 17; 9(6). PMID: 25771305    Free PMC article.
Molecular signatures discriminating the male and the female sexual pathways in the pearl oyster Pinctada margaritifera.
Vaihiti Teaniniuraitemoana, Arnaud Huvet, +3 authors, Gilles Le Moullac.
PLoS One, 2015 Mar 31; 10(3). PMID: 25815473    Free PMC article.
Integrative analysis of survival-associated gene sets in breast cancer.
Frederick S Varn, Matthew H Ung, Shao Ke Lou, Chao Cheng.
BMC Med Genomics, 2015 Apr 17; 8. PMID: 25881247    Free PMC article.
Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value.
Brian David Lehmann, Yan Ding, +6 authors, Yajun Yi.
BMC Cancer, 2015 Apr 18; 15. PMID: 25886164    Free PMC article.
Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer--the INNODIAG study.
Tatiana Kempowsky-Hamon, Carine Valle, +12 authors, Véronique Anton-Leberre.
BMC Med Genomics, 2015 Apr 19; 8. PMID: 25888889    Free PMC article.
High-throughput RNAi screening of human kinases identifies predictors of clinical outcome in colorectal cancer patients treated with oxaliplatin.
Moubin Lin, Yajie Zhang, +9 authors, Huaguang Li.
Oncotarget, 2015 Apr 24; 6(18). PMID: 25904054    Free PMC article.
Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy.
Daniel L Abravanel, George K Belka, +4 authors, Lewis A Chodosh.
J Clin Invest, 2015 May 12; 125(6). PMID: 25961456    Free PMC article.
Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk.
Jason De Melo, Damu Tang.
PLoS One, 2015 May 21; 10(5). PMID: 25992689    Free PMC article.
Association of Protein Translation and Extracellular Matrix Gene Sets with Breast Cancer Metastasis: Findings Uncovered on Analysis of Multiple Publicly Available Datasets Using Individual Patient Data Approach.
Nilotpal Chowdhury, Shantanu Sapru.
PLoS One, 2015 Jun 17; 10(6). PMID: 26080057    Free PMC article.
The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies.
Jennifer L Beebe-Dimmer, Matthew Hathcock, +5 authors, Stephen N Thibodeau.
Cancer Epidemiol Biomarkers Prev, 2015 Jun 26; 24(9). PMID: 26108461    Free PMC article.
Tamoxifen induces a pluripotency signature in breast cancer cells and human tumors.
George Notas, Vassiliki Pelekanou, +8 authors, Elias Castanas.
Mol Oncol, 2015 Jun 28; 9(9). PMID: 26115764    Free PMC article.
Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer.
Y-W Chang, C-F Tseng, +5 authors, J-L Su.
Oncogene, 2015 Jun 30; 35(12). PMID: 26119938
Proangiogenic Properties of Thrombospondin-4.
Santoshi Muppala, Ella Frolova, +6 authors, Olga Stenina-Adognravi.
Arterioscler Thromb Vasc Biol, 2015 Jul 04; 35(9). PMID: 26139464    Free PMC article.
Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.
V Felzen, C Hiebel, +6 authors, T Morawe.
Cell Death Dis, 2015 Jul 15; 6. PMID: 26158518    Free PMC article.
Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis.
Nezaket Turkel, Marta Portela, +3 authors, Helena E Richardson.
Biol Open, 2015 Jul 19; 4(8). PMID: 26187947    Free PMC article.
Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis.
Ai-Chung Mar, Chun-Ho Chu, +5 authors, Te-Chang Lee.
J Biol Chem, 2015 Jul 26; 290(36). PMID: 26209639    Free PMC article.
Host genotype and tumor phenotype of chemokine decoy receptors integrally affect breast cancer relapse.
Ke-Da Yu, Xin Wang, +2 authors, Zhi-Ming Shao.
Oncotarget, 2015 Sep 01; 6(28). PMID: 26314842    Free PMC article.
Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning.
Stephanie N Dorman, Katherina Baranova, +4 authors, Peter K Rogan.
Mol Oncol, 2015 Sep 16; 10(1). PMID: 26372358    Free PMC article.
Statistical Methods for Establishing Personalized Treatment Rules in Oncology.
Junsheng Ma, Brian P Hobbs, Francesco C Stingo.
Biomed Res Int, 2015 Oct 09; 2015. PMID: 26446492    Free PMC article.
Review.
Tamoxifen therapy benefit predictive signature coupled with prognostic signature of post-operative recurrent risk for early stage ER+ breast cancer.
Hao Cai, Xiangyu Li, +6 authors, Zheng Guo.
Oncotarget, 2015 Nov 04; 6(42). PMID: 26527319    Free PMC article.
Prospective assessment of the decision-making impact of the Breast Cancer Index in recommending extended adjuvant endocrine therapy for patients with early-stage ER-positive breast cancer.
Tara Sanft, Bilge Aktas, +11 authors, Lajos Pusztai.
Breast Cancer Res Treat, 2015 Nov 19; 154(3). PMID: 26578401    Free PMC article.
The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.
Christina G Towers, Anna L Guarnieri, +13 authors, Heide L Ford.
Nat Commun, 2015 Dec 22; 6. PMID: 26687066    Free PMC article.
Breast cancer intrinsic subtype classification, clinical use and future trends.
Xiaofeng Dai, Ting Li, +4 authors, Bozhi Shi.
Am J Cancer Res, 2015 Dec 23; 5(10). PMID: 26693050    Free PMC article.
Highly Cited. Review.
Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.
Gabriella Aquino, Renato Franco, +9 authors, Monica Cantile.
Am J Cancer Res, 2015 Dec 23; 5(10). PMID: 26693058    Free PMC article.
Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer.
Chunri Yan, Ye-Hwan Kim, +9 authors, Wun-Jae Kim.
J Korean Med Sci, 2015 Dec 30; 30(12). PMID: 26713053    Free PMC article.
Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study.
Dennis C Sgroi, Judy-Anne W Chapman, +10 authors, Michael Pollak.
Breast Cancer Res, 2016 Jan 06; 18(1). PMID: 26728744    Free PMC article.
Interleukin-17 Could Promote Breast Cancer Progression at Several Stages of the Disease.
Thomas Welte, Xiang H-F Zhang.
Mediators Inflamm, 2016 Jan 20; 2015. PMID: 26783383    Free PMC article.
Review.
HOX genes: Major actors in resistance to selective endocrine response modifiers.
Kideok Jin, Saraswati Sukumar.
Biochim Biophys Acta, 2016 Jan 26; 1865(2). PMID: 26803986    Free PMC article.
Review.
MetaKTSP: a meta-analytic top scoring pair method for robust cross-study validation of omics prediction analysis.
SungHwan Kim, Chien-Wei Lin, George C Tseng.
Bioinformatics, 2016 May 07; 32(13). PMID: 27153719    Free PMC article.
The dual role of asporin in breast cancer progression.
Dana Simkova, Gvantsa Kharaishvili, +11 authors, Jan Bouchal.
Oncotarget, 2016 Jul 14; 7(32). PMID: 27409832    Free PMC article.
Weighted K-means support vector machine for cancer prediction.
SungHwan Kim.
Springerplus, 2016 Aug 12; 5(1). PMID: 27512621    Free PMC article.
Improving Pathological Assessment of Breast Cancer by Employing Array-Based Transcriptome Analysis.
Zsuzsanna Mihály, Balázs Győrffy.
Microarrays (Basel), 2013 Jan 01; 2(3). PMID: 27605190    Free PMC article.
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Breast cancer classification and prognostication through diverse systems along with recent emerging findings in this respect; the dawn of new perspectives in the clinical applications.
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Tumour Biol, 2016 Sep 22; 37(11). PMID: 27651157
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RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Specimens for Gene Expression Quantification and Data Mining.
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Int J Genomics, 2016 Oct 25; 2016. PMID: 27774452    Free PMC article.
Double-edged role of G protein-coupled estrogen receptor 1 in breast cancer prognosis: an analysis of 167 breast cancer samples and online data sets.
Fan Yang, Zhi-Min Shao.
Onco Targets Ther, 2016 Nov 09; 9. PMID: 27822058    Free PMC article.
Hormonal Modulation of Breast Cancer Gene Expression: Implications for Intrinsic Subtyping in Premenopausal Women.
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Front Oncol, 2016 Nov 30; 6. PMID: 27896218    Free PMC article.
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Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy.
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PLoS One, 2016 Dec 08; 11(12). PMID: 27926932    Free PMC article.
The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells.
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Oncotarget, 2017 Jan 07; 8(6). PMID: 28060751    Free PMC article.
Meta-analytic support vector machine for integrating multiple omics data.
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BioData Min, 2017 Feb 06; 10. PMID: 28149325    Free PMC article.
Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays.
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J Surg Oncol, 2017 Feb 18; 115(6). PMID: 28211064    Free PMC article.
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Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma.
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PLoS One, 2017 Feb 23; 12(2). PMID: 28225775    Free PMC article.
ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression.
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Proc Natl Acad Sci U S A, 2017 Mar 05; 114(12). PMID: 28258171    Free PMC article.
Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line.
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Sci Rep, 2017 Apr 11; 7. PMID: 28393905    Free PMC article.
Thrombospondin-4 mediates TGF-β-induced angiogenesis.
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Oncogene, 2017 May 10; 36(36). PMID: 28481870    Free PMC article.
Clinical utility of gene-expression signatures in early stage breast cancer.
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Nat Rev Clin Oncol, 2017 Jun 01; 14(10). PMID: 28561071
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Text Mining of the Electronic Health Record: An Information Extraction Approach for Automated Identification and Subphenotyping of HFpEF Patients for Clinical Trials.
Siddhartha R Jonnalagadda, Abhishek K Adupa, +2 authors, Sanjiv J Shah.
J Cardiovasc Transl Res, 2017 Jun 07; 10(3). PMID: 28585184
Predicting Outcomes of Hormone and Chemotherapy in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) Study by Biochemically-inspired Machine Learning.
Eliseos J Mucaki, Katherina Baranova, +5 authors, Peter K Rogan.
F1000Res, 2017 Jun 20; 5. PMID: 28620450    Free PMC article.
Molecular genetics complexity impeding research progress in breast and ovarian cancers.
Ishita Gupta, Ikram Burney, Mansour S Al-Moundhri, Yahya Tamimi.
Mol Clin Oncol, 2017 Jul 08; 7(1). PMID: 28685067    Free PMC article.
PAM50 gene signatures and breast cancer prognosis with adjuvant anthracycline- and taxane-based chemotherapy: correlative analysis of C9741 (Alliance).
Minetta C Liu, Brandelyn N Pitcher, +20 authors, William T Barry.
NPJ Breast Cancer, 2016 Jan 01; 2. PMID: 28691057    Free PMC article.
The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms.
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Sci Rep, 2017 Jul 16; 7(1). PMID: 28710396    Free PMC article.
HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directions.
Hannah Brechka, Raj R Bhanvadia, Calvin VanOpstall, Donald J Vander Griend.
Genes Dis, 2017 Aug 12; 4(2). PMID: 28798948    Free PMC article.
HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC.
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Biomed Res Int, 2017 Aug 16; 2017. PMID: 28808656    Free PMC article.
Application of a co‑expression network for the analysis of aggressive and non‑aggressive breast cancer cell lines to predict the clinical outcome of patients.
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Mol Med Rep, 2017 Sep 26; 16(6). PMID: 28944917    Free PMC article.
Gene expression profiling to predict recurrence of advanced squamous cell carcinoma of the tongue: discovery and external validation.
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Oncotarget, 2017 Oct 06; 8(37). PMID: 28977904    Free PMC article.
Building Diversified Multiple Trees for classification in high dimensional noisy biomedical data.
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Health Inf Sci Syst, 2017 Oct 25; 5(1). PMID: 29062476    Free PMC article.
Clinical utility of multigene profiling assays in early-stage breast cancer.
M C Chang, L H Souter, +6 authors, Molecular Oncology Advisory Committee.
Curr Oncol, 2017 Nov 02; 24(5). PMID: 29089811    Free PMC article.
Identification of gene pairs through penalized regression subject to constraints.
Rex Shen, Lan Luo, Hui Jiang.
BMC Bioinformatics, 2017 Nov 05; 18(1). PMID: 29100492    Free PMC article.
MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells.
Min-Ho Lee, Dahae Koh, +7 authors, Mi-Ock Lee.
Autophagy, 2017 Nov 14; 14(5). PMID: 29130361    Free PMC article.
Thrombospondin-4 in tissue remodeling.
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Robust method for identification of prognostic gene signatures from gene expression profiles.
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Sci Rep, 2017 Dec 07; 7(1). PMID: 29208919    Free PMC article.
Clinical applications of urinary cell-free DNA in cancer: current insights and promising future.
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The GDNF Family: A Role in Cancer?
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Impact of the G84E variant on HOXB13 gene and protein expression in formalin-fixed, paraffin-embedded prostate tumours.
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Sci Rep, 2017 Dec 21; 7(1). PMID: 29259341    Free PMC article.
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment.
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Oncoimmunology, 2018 Feb 06; 7(3). PMID: 29399416    Free PMC article.
Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer.
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J Hematol Oncol, 2018 Feb 24; 11(1). PMID: 29471853    Free PMC article.
UBASH3B promotes tamoxifen resistance and could be negatively regulated by ESR1.
Ketao Jin, Huanrong Lan, +4 authors, Wei Wang.
Oncotarget, 2018 Mar 02; 9(9). PMID: 29492198    Free PMC article.
Prognostic & predictive factors for planning adjuvant chemotherapy of early-stage breast cancer.
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Indian J Med Res, 2018 Mar 08; 146(5). PMID: 29512598    Free PMC article.
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Investigating a multigene prognostic assay based on significant pathways for Luminal A breast cancer through gene expression profile analysis.
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Oncol Lett, 2018 Mar 17; 15(4). PMID: 29545900    Free PMC article.
Understanding Biomarkers in Early-Stage Invasive Breast Cancer: Tools From the ASCO Clinical Guideline.
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Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma.
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EBioMedicine, 2018 Jun 04; 32. PMID: 29859855    Free PMC article.
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.
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Proc Natl Acad Sci U S A, 2018 Jul 11; 115(31). PMID: 29987050    Free PMC article.
LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions.
Cristina Barbagallo, Duilia Brex, +11 authors, Marco Ragusa.
Mol Ther Nucleic Acids, 2018 Sep 10; 12. PMID: 30195762    Free PMC article.
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Breast cancer vaccination comes to age: impacts of bioinformatics.
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Bioimpacts, 2018 Sep 14; 8(3). PMID: 30211082    Free PMC article.
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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
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Genes Dis, 2018 Sep 28; 5(2). PMID: 30258937    Free PMC article.
Highly Cited. Review.
Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells.
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J Exp Clin Cancer Res, 2019 Oct 12; 38(1). PMID: 31601253    Free PMC article.
Identification of novel predictive factors for post surgical corneal haze.
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IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15-Dependent BMI1 Stability.
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OSbrca: A Web Server for Breast Cancer Prognostic Biomarker Investigation With Massive Data From Tens of Cohorts.
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Front Oncol, 2020 Jan 11; 9. PMID: 31921624    Free PMC article.
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Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes.
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CC chemokines are differentially expressed in Breast Cancer and are associated with disparity in overall survival.
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GradientScanSurv-An exhaustive association test method for gene expression data with censored survival outcome.
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Three inflammation-related genes could predict risk in prognosis and metastasis of patients with breast cancer.
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Cancer Med, 2019 Jan 12; 8(2). PMID: 30632703    Free PMC article.
Interaction Between MUC1 and STAT1 Drives IFITM1 Overexpression in Aromatase Inhibitor-Resistant Breast Cancer Cells and Mediates Estrogen-Induced Apoptosis.
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Mol Cancer Res, 2019 Jan 19; 17(5). PMID: 30655323    Free PMC article.
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
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BCL11A Promotes the Progression of Laryngeal Squamous Cell Carcinoma.
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Front Oncol, 2020 Apr 09; 10. PMID: 32266150    Free PMC article.
GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.
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Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk.
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Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy.
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Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences.
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Genome-wide analysis of therapeutic response uncovers molecular pathways governing tamoxifen resistance in ER+ breast cancer.
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Use of Low-Dose Tamoxifen to Increase Mammographic Screening Sensitivity in Premenopausal Women.
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Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer.
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NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer.
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Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin.
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