Review
. 2004 Oct; 76(6):1093-103.
doi: 10.1189/jlb.0804439.

The coordination of signaling during Fc receptor-mediated phagocytosis

Joel A Swanson 1 Adam D Hoppe  
Affiliations
  • PMID: 15466916
  •     115 citations

Abstract

Phagocytosis by macrophages can be initiated by Fcgamma receptors (FcR) in membranes that bind to Fc regions of immunoglobulin G (IgG). Activated FcR transduce signals to cytoplasm, which regulate the internalization of IgG-coated particles into plasma membrane-derived vacuoles, phagosomes. Particles internalized by phagocytosis are much larger than FcR, which prompts questions of if and how the receptors are coordinated with each other. FcR-mediated signal transduction entails recruitment of proteins from cytoplasm to the receptor, largely via protein phosphorylation. These FcR signaling complexes then activate proteins that regulate actin, myosin, membrane fusion, and the production of reactive oxygen intermediates. Recent fluorescence microscopic studies of phagocytosis in macrophages indicate that signaling by FcR occurs as a sequence of distinct stages, evident in the spatial and temporal patterns of phosphoinositides, protein kinase C, and Rho-family GTPase activation on forming phagosomes. The coordination of these stages may be regulated by lipids or lipid-anchored proteins, which diffuse away from FcR complexes. Lateral diffusion of FcR-derived signals could integrate FcR-dependent responses over large areas of membrane in the forming phagosome.

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TSMiner: a novel framework for generating time-specific gene regulatory networks from time-series expression profiles.
Mingfei Han, Xian Liu, +9 authors, Fuchu He.
Nucleic Acids Res, 2021 Jul 28; 49(18). PMID: 34313778    Free PMC article.
Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1.
Shida Shangguan, Philip K Ehrenberg, +19 authors, Rasmi Thomas.
Elife, 2021 Sep 18; 10. PMID: 34533134    Free PMC article.
Gold nanoparticles enhance antibody effect through direct cancer cell cytotoxicity by differential regulation of phagocytosis.
Linyang Fan, Weizhi Wang, Zihua Wang, Minzhi Zhao.
Nat Commun, 2021 Nov 06; 12(1). PMID: 34737259    Free PMC article.
Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis.
Daan Vorselen, Sarah R Barger, +4 authors, Mira Krendel.
Elife, 2021 Oct 29; 10. PMID: 34708690    Free PMC article.
Cancer-Cell-Derived IgG and Its Potential Role in Tumor Development.
Said Kdimati, Christina Susanne Mullins, Michael Linnebacher.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34769026    Free PMC article.
Review.
Neutrophils-From Bone Marrow to First-Line Defense of the Innate Immune System.
Richard Felix Kraus, Michael Andreas Gruber.
Front Immunol, 2022 Jan 11; 12. PMID: 35003081    Free PMC article.
Review.