Journal Article
. 2004 Dec;292(22).
doi: 10.1001/jama.292.22.2735.

Magnetic resonance imaging of the breast prior to biopsy

David A Bluemke 1 Constantine A Gatsonis  Mei Hsiu Chen  Gia A DeAngelis  Nanette DeBruhl  Steven Harms  Sylvia H Heywang-Köbrunner  Nola Hylton  Christiane K Kuhl  Constance Lehman  Etta D Pisano  Petrina Causer  Stuart J Schnitt  Stanley F Smazal  Carol B Stelling  Paul T Weatherall  Mitchell D Schnall  
  • PMID: 15585733
  •     125 citations


Context: Breast magnetic resonance imaging (MRI) has been shown to have high sensitivity for cancer detection and is increasingly used following mammography to evaluate suspicious breast lesions.

Objective: To determine the accuracy of breast MRI in conjunction with mammography for the detection of breast cancer in patients with suspicious mammographic or clinical findings.

Design, Setting, And Patients: Prospective multicenter investigation of the International Breast MR Consortium conducted at 14 university hospitals in North America and Europe from June 2, 1998, through October 31, 2001, of 821 patients referred for breast biopsy for American College of Radiology category 4 or 5 mammographic assessment or suspicious clinical or ultrasound finding.

Interventions: MRI examinations performed prior to breast biopsy; MRI results were interpreted at each site, which were blinded to pathological results.

Main Outcome Measures: Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of breast MRI.

Results: Among the 821 patients, there were 404 malignant index lesions, of which 63 were ductal carcinoma in situ (DCIS) and 341 were invasive carcinoma. Of the 417 nonmalignant index lesions, 366 were benign, 47 showed atypical histology, and 4 were lobular carcinoma in situ. The AUC pooled over all institutions was 0.88 (95% confidence interval [CI], 0.86-0.91). MRI correctly detected cancer in 356 of 404 cancer cases (DCIS or invasive cancer), resulting in a sensitivity of 88.1% (95% CI, 84.6%-91.1%), and correctly identified as negative for cancer 281 of 417 cases without cancer, resulting in a specificity of 67.7% (95% CI, 62.7%-71.9%). MRI performance was not significantly affected by mammographic breast density, tumor histology, or menopausal status. The positive predictive values for 356 of 492 patients was 72.4% (95% CI, 68.2%-76.3%) and of mammography for 367 of 695 patients was 52.8% (95% CI, 49.0%-56.6%) (P<.005). Dynamic MRI did not improve the AUC compared with 3-dimensional MRI alone, but the specificity of a washout pattern for 123 of 136 patients without cancer was 90.4% (95% CI, 84%-95%).

Conclusions: Breast MRI has high sensitivity but only moderate specificity independent of breast density, tumor type, and menopausal status. Although the positive predictive value of MRI is greater than mammography, MRI does not obviate the need for subsequent tissue sampling in this setting.

Imaging in breast cancer: magnetic resonance imaging.
Constance D Lehman, Mitchell D Schnall.
Breast Cancer Res, 2005 Sep 20; 7(5). PMID: 16168141    Free PMC article.
Morphologic blooming in breast MRI as a characterization of margin for discriminating benign from malignant lesions.
Alan Penn, Scott Thompson, +8 authors, Etta Pisano.
Acad Radiol, 2006 Oct 31; 13(11). PMID: 17070452    Free PMC article.
Patterns of enhancement on breast MR images: interpretation and imaging pitfalls.
Katarzyna J Macura, Ronald Ouwerkerk, Michael A Jacobs, David A Bluemke.
Radiographics, 2006 Nov 15; 26(6). PMID: 17102046    Free PMC article.
MRI of the breast for the detection and assessment of the size of ductal carcinoma in situ.
Do Youn Kim, Woo Kyung Moon, +7 authors, Eun Hye Lee.
Korean J Radiol, 2007 Feb 06; 8(1). PMID: 17277561    Free PMC article.
Investigation of suspected breast cancer.
Peter Britton, Ruchi Sinnatamby.
BMJ, 2007 Aug 19; 335(7615). PMID: 17703045    Free PMC article.
The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for breast tumors.
Mi Jung Park, Eun Suk Cha, +2 authors, Jun Hyun Baik.
Korean J Radiol, 2007 Oct 10; 8(5). PMID: 17923781    Free PMC article.
MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature.
Ritse M Mann, Yvonne L Hoogeveen, Johan G Blickman, Carla Boetes.
Breast Cancer Res Treat, 2007 Nov 29; 107(1). PMID: 18043894    Free PMC article.
[Magnetic resonance imaging in preoperative staging for breast cancer: pros and contras].
C K Kuhl, M Braun.
Radiologe, 2008 Mar 29; 48(4). PMID: 18369582
Breast MRI: guidelines from the European Society of Breast Imaging.
R M Mann, C K Kuhl, K Kinkel, C Boetes.
Eur Radiol, 2008 Apr 05; 18(7). PMID: 18389253    Free PMC article.
Highly Cited.
What is the sensitivity of mammography and dynamic MR imaging for DCIS if the whole-breast histopathology is used as a reference standard?
F Sardanelli, L Bacigalupo, +5 authors, A Del Maschio.
Radiol Med, 2008 Apr 17; 113(3). PMID: 18414812
Detection of choline signal in human breast lesions with chemical-shift imaging.
Hyeon-Man Baek, Jeon-Hor Chen, +3 authors, Min-Ying Su.
J Magn Reson Imaging, 2008 Apr 22; 27(5). PMID: 18425841    Free PMC article.
A Java-based fMRI processing pipeline evaluation system for assessment of univariate general linear model and multivariate canonical variate analysis-based pipelines.
Jing Zhang, Lichen Liang, +3 authors, Stephen C Strother.
Neuroinformatics, 2008 May 29; 6(2). PMID: 18506642
MR breast imaging: a comparative analysis of conventional and parallel imaging acquisition.
A Orlacchio, F Bolacchi, +4 authors, G Simonetti.
Radiol Med, 2008 Jun 05; 113(4). PMID: 18523845
Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors.
Colin M Carpenter, Subhadra Srinivasan, Brian W Pogue, Keith D Paulsen.
Opt Express, 2008 Oct 30; 16(22). PMID: 18958072    Free PMC article.
Significance of breast lesion descriptors in the ACR BI-RADS MRI lexicon.
Garima Agrawal, Min-Ying Su, +2 authors, Jeon-Hor Chen.
Cancer, 2009 Feb 07; 115(7). PMID: 19197974    Free PMC article.
Feasibility of MRI-guided large-core-needle biopsy of suspiscious breast lesions at 3 T.
Nicky H G M Peters, Carla Meeuwis, +5 authors, Maurice A A J van den Bosch.
Eur Radiol, 2009 Feb 14; 19(7). PMID: 19214520    Free PMC article.
Imaging studies for the early detection of breast cancer.
Sylvia H Heywang-Köbrunner, Ingrid Schreer, Walter Heindel, Alexander Katalinic.
Dtsch Arztebl Int, 2009 Jul 14; 105(31-32). PMID: 19593396    Free PMC article.
Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage.
Milica Medved, Gillian M Newstead, +4 authors, Gregory S Karczmar.
Magn Reson Imaging, 2009 Jul 25; 28(1). PMID: 19628350    Free PMC article.
MRI-guided vacuum-assisted breast biopsy: a phantom and patient evaluation of targeting accuracy.
Riham H El Khouli, Katarzyna J Macura, +4 authors, David A Bluemke.
J Magn Reson Imaging, 2009 Jul 25; 30(2). PMID: 19629977    Free PMC article.
Dynamic contrast-enhanced MRI of the breast: quantitative method for kinetic curve type assessment.
Riham H El Khouli, Katarzyna J Macura, +4 authors, David A Bluemke.
AJR Am J Roentgenol, 2009 Sep 23; 193(4). PMID: 19770298    Free PMC article.
Relationship of temporal resolution to diagnostic performance for dynamic contrast enhanced MRI of the breast.
Riham H El Khouli, Katarzyna J Macura, +3 authors, David A Bluemke.
J Magn Reson Imaging, 2009 Oct 27; 30(5). PMID: 19856413    Free PMC article.
MRI for breast cancer: Current indications.
Haydee Ojeda-Fournier, Christopher E Comstock.
Indian J Radiol Imaging, 2009 Nov 03; 19(2). PMID: 19881077    Free PMC article.
Estimates of sensitivity and specificity can be biased when reporting the results of the second test in a screening trial conducted in series.
Brandy M Ringham, Todd A Alonzo, Gary K Grunwald, Deborah H Glueck.
BMC Med Res Methodol, 2010 Jan 13; 10. PMID: 20064254    Free PMC article.
Modern breast cancer detection: a technological review.
Adam B Nover, Shami Jagtap, +4 authors, Ari D Brooks.
Int J Biomed Imaging, 2010 Jan 14; 2009. PMID: 20069109    Free PMC article.
Correlation between breast density in mammography and background enhancement in MR mammography.
R Cubuk, N Tasali, +3 authors, S Guney.
Radiol Med, 2010 Jan 19; 115(3). PMID: 20082222
The role of parallel diffusion-weighted imaging and apparent diffusion coefficient (ADC) map values for evaluating breast lesions: preliminary results.
Guangwei Jin, Ningyu An, Michael A Jacobs, Kuncheng Li.
Acad Radiol, 2010 Mar 09; 17(4). PMID: 20207316    Free PMC article.
Pharmacokinetic mapping for lesion classification in dynamic breast MRI.
Matthias C Schabel, Glen R Morrell, +3 authors, Leigh A Neumayer.
J Magn Reson Imaging, 2010 Jun 01; 31(6). PMID: 20512889    Free PMC article.
Diffusion-weighted imaging improves the diagnostic accuracy of conventional 3.0-T breast MR imaging.
Riham H Ei Khouli, Michael A Jacobs, +4 authors, David A Bluemke.
Radiology, 2010 Jun 25; 256(1). PMID: 20574085    Free PMC article.
Highly Cited.
Characterizing accuracy of total hemoglobin recovery using contrast-detail analysis in 3D image-guided near infrared spectroscopy with the boundary element method.
Hamid R Ghadyani, Subhadra Srinivasan, Brian W Pogue, Keith D Paulsen.
Opt Express, 2010 Aug 20; 18(15). PMID: 20720975    Free PMC article.
Breast magnetic resonance imaging as a problem-solving modality in mammographic BI-RADS 3 lesions.
M D Dorrius, R M Pijnappel, M C Jansen-van der Weide, M Oudkerk.
Cancer Imaging, 2010 Oct 01; 10 Spec no A. PMID: 20880790    Free PMC article.
Magnetic resonance imaging in the evaluation of ductal carcinoma in situ.
Constance D Lehman.
J Natl Cancer Inst Monogr, 2010 Oct 20; 2010(41). PMID: 20956821    Free PMC article.
Kinetic analysis of lesions without mass effect on breast MRI using manual and computer-assisted methods.
Tibor Vag, Pascal A T Baltzer, +4 authors, Werner A Kaiser.
Eur Radiol, 2010 Nov 11; 21(5). PMID: 21063709
Diffusion-weighted magnetic resonance imaging in focal breast lesions: analysis of 78 cases with pathological correlation.
F Fornasa, L Pinali, +2 authors, S Montemezzi.
Radiol Med, 2010 Nov 16; 116(2). PMID: 21076884
Improved diagnostic accuracy of breast MRI through combined apparent diffusion coefficients and dynamic contrast-enhanced kinetics.
S C Partridge, H Rahbar, +4 authors, C D Lehman.
Magn Reson Med, 2011 Jan 22; 65(6). PMID: 21254208    Free PMC article.
Current and future clinical applications for optical imaging of cancer: from intraoperative surgical guidance to cancer screening.
Costas G Hadjipanayis, Huabei Jiang, David W Roberts, Lily Yang.
Semin Oncol, 2011 Mar 03; 38(1). PMID: 21362519    Free PMC article.
Computer-aided detection in breast MRI: a systematic review and meta-analysis.
Monique D Dorrius, Marijke C Jansen-van der Weide, +2 authors, Matthijs Oudkerk.
Eur Radiol, 2011 Mar 16; 21(8). PMID: 21404134    Free PMC article.
Systematic Review.
The impact of preoperative magnetic resonance imaging on surgical treatment and outcomes for ductal carcinoma in situ.
Kaoru Itakura, Juan Lessing, +8 authors, E Shelley Hwang.
Clin Breast Cancer, 2011 Mar 23; 11(1). PMID: 21421520    Free PMC article.
Improved hardware for higher spatial resolution strain-encoded (SENC) breast MRI for strain measurements.
Ahmed A Harouni, Jakir Hossain, Michael A Jacobs, Nael F Osman.
Acad Radiol, 2011 Mar 29; 18(6). PMID: 21440464    Free PMC article.
Breast MRI utilization in older patients with newly diagnosed breast cancer.
Courtney A Sommer, Karyn B Stitzenberg, +2 authors, Timothy S Carey.
J Surg Res, 2011 Jun 11; 170(1). PMID: 21658724    Free PMC article.
MRI in breast cancer therapy monitoring.
Rebekah McLaughlin, Nola Hylton.
NMR Biomed, 2011 Jun 22; 24(6). PMID: 21692116    Free PMC article.
Computerized three-class classification of MRI-based prognostic markers for breast cancer.
Neha Bhooshan, Maryellen Giger, +6 authors, Gillian Newstead.
Phys Med Biol, 2011 Aug 24; 56(18). PMID: 21860079    Free PMC article.
Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images.
Milica Medved, Xiaobing Fan, +8 authors, Gregory S Karczmar.
Acad Radiol, 2011 Oct 04; 18(12). PMID: 21962476    Free PMC article.
Breast cancer risk assessment in 64,659 women at a single high-volume mammography clinic.
John T Brinton, Lora D Barke, +3 authors, Deborah H Glueck.
Acad Radiol, 2011 Nov 08; 19(1). PMID: 22054804    Free PMC article.
The added value of quantitative multi-voxel MR spectroscopy in breast magnetic resonance imaging.
M D Dorrius, R M Pijnappel, +4 authors, P E Sijens.
Eur Radiol, 2011 Nov 15; 22(4). PMID: 22076317    Free PMC article.
3-T dynamic contrast-enhanced MRI of the breast: pharmacokinetic parameters versus conventional kinetic curve analysis.
Riham H El Khouli, Katarzyna J Macura, +2 authors, David A Bluemke.
AJR Am J Roentgenol, 2011 Nov 24; 197(6). PMID: 22109308    Free PMC article.
Image-Based Treatment Planning of the Post-Lumpectomy Breast Utilizing CT and 3TMRI.
Geraldine Jacobson, Gideon Zamba, +2 authors, Joni Buechler-Price.
Int J Breast Cancer, 2012 Feb 02; 2011. PMID: 22295215    Free PMC article.
Positive predictive value of BI-RADS MR imaging.
Mary C Mahoney, Constantine Gatsonis, +2 authors, Constance Lehman.
Radiology, 2012 May 17; 264(1). PMID: 22589320    Free PMC article.
Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system.
Wei-Cheng Kuo, Jongsik Kim, +3 authors, Stephen A Boppart.
Biomed Opt Express, 2012 Jun 29; 3(6). PMID: 22741064    Free PMC article.
A method for limiting pitfalls in the production of enhancement kinetic curves in 3T dynamic magnetic resonance mammography.
Eleftherios Lavdas, Panayiotis Mavroidis, +4 authors, Katerina Vassiou.
J Thorac Dis, 2012 Aug 31; 4(4). PMID: 22934138    Free PMC article.
Breast MRI use uncommon among U.S. women.
Jacqueline W Miller, Susan A Sabatino, +5 authors, Rachel Ballard-Barbash.
Cancer Epidemiol Biomarkers Prev, 2012 Nov 17; 22(1). PMID: 23155135    Free PMC article.
Classification of breast lesions pre-contrast injection using water resonance lineshape analysis.
Abbie M Wood, Milica Medved, +7 authors, Greg S Karczmar.
NMR Biomed, 2012 Nov 21; 26(5). PMID: 23165988    Free PMC article.
Strain-encoded breast MRI in phantom and ex vivo specimens with histological validation: preliminary results.
Ahmed A Haruoni, Jakir Hossain, +4 authors, Michael A Jacobs.
Med Phys, 2012 Dec 13; 39(12). PMID: 23231318    Free PMC article.
Contrast-noise-ratio (CNR) analysis and optimisation of breast-specific gamma imaging (BSGI) acquisition protocols.
Dennis Dickerscheid, Jules Lavalaye, Leo Romijn, Jan Habraken.
EJNMMI Res, 2013 Mar 28; 3(1). PMID: 23531207    Free PMC article.
The potential for an enhanced role for MRI in radiation-therapy treatment planning.
P Metcalfe, G P Liney, +5 authors, W Tome.
Technol Cancer Res Treat, 2013 Apr 27; 12(5). PMID: 23617289    Free PMC article.
Differentiation of breast cancer from fibroadenoma with dual-echo dynamic contrast-enhanced MRI.
Shiwei Wang, Zachary Delproposto, +4 authors, Maosheng Xu.
PLoS One, 2013 Jul 12; 8(7). PMID: 23844077    Free PMC article.
Is the use of preoperative breast MRI predictive of mastectomy?
Brigid K Killelea, Baiba J Grube, +3 authors, Donald R Lannin.
World J Surg Oncol, 2013 Jul 16; 11. PMID: 23849218    Free PMC article.
Gd-labeled glycol chitosan as a pH-responsive magnetic resonance imaging agent for detecting acidic tumor microenvironments.
Kido Nwe, Ching-Hui Huang, Andrew Tsourkas.
J Med Chem, 2013 Sep 21; 56(20). PMID: 24044414    Free PMC article.
Integration of microwave tomography with magnetic resonance for improved breast imaging.
Paul M Meaney, Amir H Golnabi, +4 authors, Keith D Paulsen.
Med Phys, 2013 Oct 05; 40(10). PMID: 24089930    Free PMC article.
Features of occult invasion in biopsy-proven DCIS at breast MRI.
Dorota Jakubowski Wisner, E Shelley Hwang, +5 authors, Nola M Hylton.
Breast J, 2013 Oct 30; 19(6). PMID: 24165314    Free PMC article.
Patterns of breast magnetic resonance imaging use in community practice.
Karen J Wernli, Wendy B DeMartini, +8 authors, Breast Cancer Surveillance Consortium.
JAMA Intern Med, 2013 Nov 20; 174(1). PMID: 24247555    Free PMC article.
Invasive ductolobular carcinoma of the breast: spectrum of mammographic, ultrasound and magnetic resonance imaging findings correlated with proportion of the lobular component.
Gisela Lg Menezes, Maurice Aaj van den Bosch, +4 authors, Ruud M Pijnappel.
Springerplus, 2013 Dec 18; 2. PMID: 24340243    Free PMC article.
The effects of applying breast compression in dynamic contrast material-enhanced MR imaging.
Riham H El Khouli, Katarzyna J Macura, +2 authors, Michael A Jacobs.
Radiology, 2014 Mar 14; 272(1). PMID: 24620911    Free PMC article.
Computerized breast mass detection using multi-scale Hessian-based analysis for dynamic contrast-enhanced MRI.
Yan-Hao Huang, Yeun-Chung Chang, +2 authors, Ruey-Feng Chang.
J Digit Imaging, 2014 Apr 02; 27(5). PMID: 24687641    Free PMC article.
Additional diagnostic value of MRI in patients with suspicious breast lesions based on ultrasound.
O Sarica, F Uluc.
Br J Radiol, 2014 Jul 02; 87(1041). PMID: 24983629    Free PMC article.
Readout-segmented echo-planar imaging in diffusion-weighted mr imaging in breast cancer: comparison with single-shot echo-planar imaging in image quality.
Yun Ju Kim, Sung Hun Kim, +5 authors, Byung Joo Song.
Korean J Radiol, 2014 Jul 24; 15(4). PMID: 25053898    Free PMC article.
Effect of b value and pre-admission of contrast on diagnostic accuracy of 1.5-T breast DWI: a systematic review and meta-analysis.
Monique D Dorrius, Hildebrand Dijkstra, Matthijs Oudkerk, Paul E Sijens.
Eur Radiol, 2014 Aug 12; 24(11). PMID: 25103535
Systematic Review.
The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples.
Avice M O'Connell, Andrew Karellas, Srinivasan Vedantham.
Breast J, 2014 Sep 10; 20(6). PMID: 25199995    Free PMC article.
Multiparametric evaluation of breast lesions using PET-MRI: initial results and future perspectives.
Almir G V Bitencourt, Eduardo N P Lima, +4 authors, Marcos D Guimarães.
Medicine (Baltimore), 2014 Nov 15; 93(22). PMID: 25396329    Free PMC article.
Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance.
Michael A Mastanduno, Junqing Xu, +8 authors, Keith D Paulsen.
Biomed Opt Express, 2014 Nov 18; 5(9). PMID: 25401024    Free PMC article.
Follow-up design of unexpected enhancing lesions on preoperative MRI of breast cancer patients.
Joo Yeon Cheung, Jin Hee Moon.
Diagn Interv Radiol, 2014 Nov 29; 21(1). PMID: 25430525    Free PMC article.
Preliminary in vivo breast vibro-acoustography results with a quasi-2-d array transducer: a step forward.
Mohammad Mehrmohammadi, Robert T Fazzio, +4 authors, Azra Alizad.
Ultrasound Med Biol, 2014 Dec 03; 40(12). PMID: 25438862    Free PMC article.
Location of triple-negative breast cancers: comparison with estrogen receptor-positive breast cancers on MR imaging.
Won Hwa Kim, Wonshik Han, +3 authors, Woo Kyung Moon.
PLoS One, 2015 Jan 22; 10(1). PMID: 25608004    Free PMC article.
Parameters of dynamic contrast-enhanced MRI as imaging markers for angiogenesis and proliferation in human breast cancer.
Lin Li, Kai Wang, +4 authors, Baozhong Shen.
Med Sci Monit, 2015 Feb 03; 21. PMID: 25640082    Free PMC article.
Breast cancer: a new imaging approach as an addition to existing guidelines.
Monique D Dorrius, Erik F J de Vries, Riemer H J A Slart, Andor W J M Glaudemans.
Eur J Nucl Med Mol Imaging, 2015 Mar 13; 42(6). PMID: 25761830
Added value of semi-quantitative breast-specific gamma imaging in the work-up of suspicious breast lesions compared to mammography, ultrasound and 3-T MRI.
T Meissnitzer, A Seymer, +4 authors, M W Meissnitzer.
Br J Radiol, 2015 Apr 18; 88(1051). PMID: 25882690    Free PMC article.
Quantitative discrimination between invasive ductal carcinomas and benign lesions based on semi-automatic analysis of time intensity curves from breast dynamic contrast enhanced MRI.
Jiandong Yin, Jiawen Yang, +2 authors, Wei Zhang.
J Exp Clin Cancer Res, 2015 Apr 19; 34. PMID: 25887917    Free PMC article.
Computer-aided detection (CAD) system for breast MRI in assessment of local tumor extent, nodal status, and multifocality of invasive breast cancers: preliminary study.
Sung Eun Song, Bo Kyoung Seo, +5 authors, Soon-Sun Kwon.
Cancer Imaging, 2015 Apr 19; 15. PMID: 25888983    Free PMC article.
Additional findings at preoperative breast MRI: the value of second-look digital breast tomosynthesis.
Paola Clauser, Luca A Carbonaro, +4 authors, Francesco Sardanelli.
Eur Radiol, 2015 Apr 24; 25(10). PMID: 25903704
MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI.
Michael A Mastanduno, Junqing Xu, +8 authors, Keith D Paulsen.
Clin Cancer Res, 2015 May 29; 21(17). PMID: 26019171    Free PMC article.
Multiparametric and Multimodality Functional Radiological Imaging for Breast Cancer Diagnosis and Early Treatment Response Assessment.
Michael A Jacobs, Antonio C Wolff, +5 authors, Richard Wahl.
J Natl Cancer Inst Monogr, 2015 Jun 13; 2015(51). PMID: 26063885    Free PMC article.
The Changing World of Breast Cancer: A Radiologist's Perspective.
Christiane K Kuhl.
Invest Radiol, 2015 Jun 18; 50(9). PMID: 26083829    Free PMC article.
Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology.
M Heijblom, D Piras, +7 authors, S Manohar.
Sci Rep, 2015 Jul 15; 5. PMID: 26159440    Free PMC article.
Highly Cited.
Optical imaging for breast cancer prescreening.
Anuradha Godavarty, Suset Rodriguez, Young-Jin Jung, Stephanie Gonzalez.
Breast Cancer (Dove Med Press), 2015 Aug 01; 7. PMID: 26229503    Free PMC article.
Multiparametric MR Imaging of Breast Cancer.
Habib Rahbar, Savannah C Partridge.
Magn Reson Imaging Clin N Am, 2015 Nov 29; 24(1). PMID: 26613883    Free PMC article.
The Yield of Pre-operative Breast MRI in Patients According to Breast Tissue Density.
Jean M Seely, Leslie Lamb, Neera Malik, Jacqueline Lau.
Eur Radiol, 2015 Dec 02; 26(9). PMID: 26620958
Computer-Aided Diagnosis Scheme for Distinguishing Between Benign and Malignant Masses in Breast DCE-MRI.
Emi Honda, Ryohei Nakayama, Hitoshi Koyama, Akiyoshi Yamashita.
J Digit Imaging, 2015 Dec 23; 29(3). PMID: 26691512    Free PMC article.
Using lesion washout volume fraction as a biomarker to improve suspicious breast lesion characterization.
Jie Huang, Sarah M Schafer, Gerald R Aben, Lori A Hoisington.
J Appl Clin Med Phys, 2015 Dec 25; 16(5). PMID: 26699291    Free PMC article.
Assessment of Background Parenchymal Enhancement and Lesion Kinetics in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls Using Quantitative Kinetic Analysis.
Alana A Lewin, Sungheon Gene Kim, +5 authors, Linda Moy.
Acad Radiol, 2016 Jan 18; 23(3). PMID: 26774741    Free PMC article.
MRI in the differential diagnosis of primary architectural distortion detected by mammography.
Lifang Si, Renyou Zhai, +3 authors, Tao Jiang.
Diagn Interv Radiol, 2016 Feb 24; 22(2). PMID: 26899149    Free PMC article.
3D microwave tomography of the breast using prior anatomical information.
Amir H Golnabi, Paul M Meaney, Keith D Paulsen.
Med Phys, 2016 Apr 03; 43(4). PMID: 27036589    Free PMC article.
Kinetic Curve Type Assessment for Classification of Breast Lesions Using Dynamic Contrast-Enhanced MR Imaging.
Shih-Neng Yang, Fang-Jing Li, +3 authors, Tzung-Chi Huang.
PLoS One, 2016 Apr 08; 11(4). PMID: 27055113    Free PMC article.
Incidentally detected enhancing lesions found in breast MRI: analysis of apparent diffusion coefficient and T2 signal intensity significantly improves specificity.
Otso Arponen, Amro Masarwah, +6 authors, Mazen Sudah.
Eur Radiol, 2016 Apr 27; 26(12). PMID: 27114285
Diagnostic Performance of Fused Diffusion-Weighted Imaging Using Unenhanced or Postcontrast T1-Weighted MR Imaging in Patients With Breast Cancer.
Hee Jung Shin, Eun Young Chae, +5 authors, Hak Hee Kim.
Medicine (Baltimore), 2016 Apr 29; 95(17). PMID: 27124054    Free PMC article.
Intraoperative Supine Breast MR Imaging to Quantify Tumor Deformation and Detection of Residual Breast Cancer: Preliminary Results.
Eva C Gombos, Jagadeesan Jayender, +4 authors, Mehra Golshan.
Radiology, 2016 Jun 23; 281(3). PMID: 27332738    Free PMC article.
Predictive model for contrast-enhanced ultrasound of the breast: Is it feasible in malignant risk assessment of breast imaging reporting and data system 4 lesions?
Jun Luo, Ji-Dong Chen, +6 authors, Jing-Qiao Lu.
World J Radiol, 2016 Jul 01; 8(6). PMID: 27358688    Free PMC article.
Retrospective and comparative analysis of (99m)Tc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese women.
Xiuyan Yu, Guoming Hu, +7 authors, Jian Huang.
BMC Cancer, 2016 Jul 13; 16. PMID: 27401536    Free PMC article.
Changes of T2 Relaxation Time From Neoadjuvant Chemotherapy in Breast Cancer Lesions.
Li Liu, Bo Yin, +2 authors, Wei Jun Peng.
Iran J Radiol, 2016 Nov 18; 13(3). PMID: 27853488    Free PMC article.
Takeaways from Pre-Contrast T1 and T2 Breast Magnetic Resonance Imaging in Women with Recently Diagnosed Breast Cancer.
Seung Hee Han, Yeong Yi An, +2 authors, Eun Jae Lee.
Iran J Radiol, 2016 Nov 30; 13(4). PMID: 27895875    Free PMC article.
Novel High Spatiotemporal Resolution Versus Standard-of-Care Dynamic Contrast-Enhanced Breast MRI: Comparison of Image Quality.
Courtney K Morrison, Leah C Henze Bancroft, +5 authors, Roberta M Strigel.
Invest Radiol, 2016 Nov 30; 52(4). PMID: 27898602    Free PMC article.
1H-MR spectroscopy of suspicious breast mass lesions at 3T: a clinical experience.
Stefania Montemezzi, Carlo Cavedon, +4 authors, Francesco Sardanelli.
Radiol Med, 2016 Dec 17; 122(3). PMID: 27981485
Is the necrosis/wall ADC ratio useful for the differentiation of benign and malignant breast lesions?
Irmak Durur-Subasi, Afak Durur-Karakaya, +3 authors, Fatih Alper.
Br J Radiol, 2017 Mar 25; 90(1073). PMID: 28339285    Free PMC article.
MRI appearance of invasive subcentimetre breast carcinoma: benign characteristics are common.
Matthias Meissnitzer, D David Dershaw, +3 authors, Elizabeth A Morris.
Br J Radiol, 2017 Apr 30; 90(1074). PMID: 28452624    Free PMC article.
Diffusion-weighted imaging of suspicious (BI-RADS 4) breast lesions: stratification based on histopathology.
João Ricardo Maltez de Almeida, André Boechat Gomes, +2 authors, Mario de Souza Rocha.
Radiol Bras, 2017 Jul 04; 50(3). PMID: 28670026    Free PMC article.
Breast magnetic resonance imaging: are those who need it getting it?
S Tan, J David, +6 authors, I Trop.
Curr Oncol, 2017 Jul 07; 24(3). PMID: 28680288    Free PMC article.
Current Controversies on the Use of Magnetic Resonance Imaging in the Management of Breast Cancer.
Edibaldo Silva.
World J Oncol, 2011 Jun 01; 2(3). PMID: 29147232    Free PMC article.
Overutilization of Breast Cancer Screening in the US: Awareness of a Growing Problem.
Mara A Schonberg.
J Gen Intern Med, 2017 Dec 22; 33(3). PMID: 29264700    Free PMC article.
Distinguishing benign and malignant breast tumors: preliminary comparison of kinetic modeling approaches using multi-institutional dynamic contrast-enhanced MRI data from the International Breast MR Consortium 6883 trial.
Anna G Sorace, Savannah C Partridge, +5 authors, Thomas E Yankeelov.
J Med Imaging (Bellingham), 2018 Feb 03; 5(1). PMID: 29392160    Free PMC article.
Role of quantitative analysis of T2 relaxation time in differentiating benign from malignant breast lesions.
Li Liu, Bo Yin, +5 authors, Weijun Peng.
J Int Med Res, 2018 Mar 21; 46(5). PMID: 29557239    Free PMC article.
Discrimination between malignant and benign mass-like lesions from breast dynamic contrast enhanced MRI: semi-automatic vs. manual analysis of the signal time-intensity curves.
Jiandong Yin, Jiawen Yang, Zejun Jiang.
J Cancer, 2018 Mar 28; 9(5). PMID: 29581761    Free PMC article.
Direct Regularization From Co-Registered Contrast MRI Improves Image Quality of MRI-Guided Near-Infrared Spectral Tomography of Breast Lesions.
Limin Zhang, Shudong Jiang, +3 authors, Keith D Paulsen.
IEEE Trans Med Imaging, 2018 May 05; 37(5). PMID: 29727287    Free PMC article.
US and MRI in the evaluation of mammographic BI-RADS 4 and 5 microcalcifications.
Ana Hrkac Pustahija, Gordana Ivanac, Boris Brkljacic.
Diagn Interv Radiol, 2018 Aug 10; 24(4). PMID: 30091708    Free PMC article.
Kinetic Analysis of Lesions Identified on a Rapid Abridged Multiphase (RAMP) Breast MRI Protocol.
Sadia Choudhery, Shinn-Huey S Chou, +2 authors, Constance D Lehman.
Acad Radiol, 2019 May 31; 27(5). PMID: 31147233    Free PMC article.
Can apparent diffusion coefficient (ADC) distinguish breast cancer from benign breast findings? A meta-analysis based on 13 847 lesions.
Alexey Surov, Hans Jonas Meyer, Andreas Wienke.
BMC Cancer, 2019 Oct 17; 19(1). PMID: 31615463    Free PMC article.
Multiparametric deep learning tissue signatures for a radiological biomarker of breast cancer: Preliminary results.
Vishwa S Parekh, Katarzyna J Macura, +4 authors, Michael A Jacobs.
Med Phys, 2019 Oct 11; 47(1). PMID: 31598978    Free PMC article.
3-D Microwave Tomography Using the Soft Prior Regularization Technique: Evaluation in Anatomically Realistic MRI-Derived Numerical Breast Phantoms.
Amir H Golnabi, Paul M Meaney, Shireen D Geimer, Keith D Paulsen.
IEEE Trans Biomed Eng, 2019 Jan 11; 66(9). PMID: 30629488    Free PMC article.
Multiparametric radiomics methods for breast cancer tissue characterization using radiological imaging.
Vishwa S Parekh, Michael A Jacobs.
Breast Cancer Res Treat, 2020 Feb 06; 180(2). PMID: 32020435    Free PMC article.
The MRI characteristics of non-mass enhancement lesions of the breast: associations with malignancy.
Hale Aydin.
Br J Radiol, 2019 Jan 24; 92(1096). PMID: 30673299    Free PMC article.
Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. the COVID-19 pandemic breast cancer consortium.
Jill R Dietz, Meena S Moran, +16 authors, Katharine A Yao.
Breast Cancer Res Treat, 2020 Apr 26; 181(3). PMID: 32333293    Free PMC article.
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Pretreatment apparent diffusion coefficient does not predict therapy response to neoadjuvant chemotherapy in breast cancer.
Alexey Surov, Andreas Wienke, Hans Jonas Meyer.
Breast, 2020 Jul 12; 53. PMID: 32652460    Free PMC article.
Clinical Feasibility of Reduced Field-of-View Diffusion-Weighted Magnetic Resonance Imaging with Computed Diffusion-Weighted Imaging Technique in Breast Cancer Patients.
Eun Cho, Jin Hwa Lee, +6 authors, Tetsuya Wakayama.
Diagnostics (Basel), 2020 Aug 06; 10(8). PMID: 32751723    Free PMC article.
Classification of breast mass lesions on dynamic contrast-enhanced magnetic resonance imaging by a computer-assisted diagnosis system based on quantitative analysis.
Jiandong Yin, Jiawen Yang, Zejun Jiang.
Oncol Lett, 2019 Mar 15; 17(3). PMID: 30867727    Free PMC article.
Diagnostic Performance of Multiparametric MR Imaging at 3.0 Tesla in Discriminating Prostate Cancer from Prostatitis: A Histopathologic Correlation.
Elif Peker, Didem Yasemin Sonmez, +3 authors, Ayse Erden.
Eurasian J Med, 2019 Mar 27; 51(1). PMID: 30911253    Free PMC article.
Functionalized nanoparticles with targeted antibody to enhance imaging of breast cancer in vivo.
Jesse S Chen, Jingwen Chen, +6 authors, Su He Wang.
J Nanobiotechnology, 2020 Sep 20; 18(1). PMID: 32948179    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor.
Jianguo Lai, Jinjiang Lin, +7 authors, Fengyan Yu.
J Cancer, 2021 Jan 07; 12(3). PMID: 33403037    Free PMC article.