A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

Soonmyung Paik ¹, Steven Shak , Gong Tang , Chungyeul Kim , Joffre Baker , Maureen Cronin , Frederick L Baehner , Michael G Walker , Drew Watson , Taesung Park , William Hiller , Edwin R Fisher , D Lawrence Wickerham , John Bryant , Norman Wolmark

Affiliations

¹ Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA. spaik.nejm@nsabp.org <spaik.nejm@nsabp.org>

PMID: 15591335
1799 citations

Abstract

Background: The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures.

Methods: We tested whether the results of a reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of 21 prospectively selected genes in paraffin-embedded tumor tissue would correlate with the likelihood of distant recurrence in patients with node-negative, tamoxifen-treated breast cancer who were enrolled in the National Surgical Adjuvant Breast and Bowel Project clinical trial B-14. The levels of expression of 16 cancer-related genes and 5 reference genes were used in a prospectively defined algorithm to calculate a recurrence score and to determine a risk group (low, intermediate, or high) for each patient.

Results: Adequate RT-PCR profiles were obtained in 668 of 675 tumor blocks. The proportions of patients categorized as having a low, intermediate, or high risk by the RT-PCR assay were 51, 22, and 27 percent, respectively. The Kaplan-Meier estimates of the rates of distant recurrence at 10 years in the low-risk, intermediate-risk, and high-risk groups were 6.8 percent (95 percent confidence interval, 4.0 to 9.6), 14.3 percent (95 percent confidence interval, 8.3 to 20.3), and 30.5 percent (95 percent confidence interval, 23.6 to 37.4). The rate in the low-risk group was significantly lower than that in the high-risk group (P<0.001). In a multivariate Cox model, the recurrence score provided significant predictive power that was independent of age and tumor size (P<0.001). The recurrence score was also predictive of overall survival (P<0.001) and could be used as a continuous function to predict distant recurrence in individual patients.

Conclusions: The recurrence score has been validated as quantifying the likelihood of distant recurrence in tamoxifen-treated patients with node-negative, estrogen-receptor-positive breast cancer.

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Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer. James J Dignam, Vanja Dukic, +3 authors, Norman Wolmark. less Breast Cancer Res Treat, 2008 Oct 03; 116(3). PMID: 18830816 Free PMC article.
Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes. Golareh Habibi, Samuel Leung, +7 authors, Sandra E Dunn. less Breast Cancer Res, 2008 Oct 18; 10(5). PMID: 18925950 Free PMC article.
Chemosensitivity and stratification by a five monoclonal antibody immunohistochemistry test in the NSABP B14 and B20 trials. Douglas T Ross, Chung-Yeul Kim, +7 authors, Norman Wolmark. less Clin Cancer Res, 2008 Oct 18; 14(20). PMID: 18927301 Free PMC article.
The half century of clinical trials of the National Surgical Adjuvant Breast And Bowel Project. D Lawrence Wickerham, Michael J O'Connell, +8 authors, Norman Wolmark. less Semin Oncol, 2008 Oct 22; 35(5). PMID: 18929150 Free PMC article. Review.
New wirings in the survivin networks. D C Altieri. Oncogene, 2008 Oct 22; 27(48). PMID: 18931693 Free PMC article. Review.
Current research topics in endocrine therapy for breast cancer. Hiroko Yamashita. Int J Clin Oncol, 2008 Oct 24; 13(5). PMID: 18946747 Review.
Gene expression profiling of breast cancer. Ting Bao, Nancy E Davidson. Adv Surg, 2008 Oct 29; 42. PMID: 18953822 Free PMC article. Review.
Chemotherapy use for hormone receptor-positive, lymph node-negative breast cancer. Michael J Hassett, Melissa E Hughes, +7 authors, Jane C Weeks. less J Clin Oncol, 2008 Oct 29; 26(34). PMID: 18955448 Free PMC article.
Lost in translation: problems and pitfalls in translating laboratory observations to clinical utility. Richard Simon. Eur J Cancer, 2008 Nov 04; 44(18). PMID: 18977655 Free PMC article. Review.
Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types. M H W Starmans, B Krishnapuram, +8 authors, P Lambin. less Br J Cancer, 2008 Nov 06; 99(11). PMID: 18985037 Free PMC article.
Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer. Charles Swanton, Zoltan Szallasi, James D Brenton, Julian Downward. Breast Cancer Res, 2008 Nov 07; 10(5). PMID: 18986507 Free PMC article. Review.
A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer. Fabien Reyal, Martin H van Vliet, +10 authors, Lodewyk F A Wessels. less Breast Cancer Res, 2008 Nov 19; 10(6). PMID: 19014521 Free PMC article.
Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature. Andrew Tutt, Alice Wang, +21 authors, Fred Waldman. less BMC Cancer, 2008 Nov 26; 8. PMID: 19025599 Free PMC article.
Ebp1 expression in benign and malignant prostate. Philippe O Gannon, Ismaël Hervé Koumakpayi, +3 authors, Fred Saad. less Cancer Cell Int, 2008 Nov 26; 8. PMID: 19025630 Free PMC article.
A functional Notch-survivin gene signature in basal breast cancer. Connie W Lee, Karl Simin, +5 authors, Dario C Altieri. less Breast Cancer Res, 2008 Nov 26; 10(6). PMID: 19025652 Free PMC article.
Gene expression variation between distinct areas of breast cancer measured from paraffin-embedded tissue cores. Martina Schobesberger, Anna Baltzer, +4 authors, Rolf Jaggi. less BMC Cancer, 2008 Nov 27; 8. PMID: 19032762 Free PMC article.
Educational and social-ethical issues in the pursuit of molecular medicine. Panagiotis A Konstantinopoulos, Michalis V Karamouzis, Athanasios G Papavassiliou. Mol Med, 2008 Dec 02; 15(1-2). PMID: 19043478 Free PMC article. Review.
BAG-1 predicts patient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast. E K A Millar, L R Anderson, +9 authors, A J Butt. less Br J Cancer, 2008 Dec 11; 100(1). PMID: 19066611 Free PMC article.
Advances in breast cancer: pathways to personalized medicine. Olufunmilayo I Olopade, Tatyana A Grushko, Rita Nanda, Dezheng Huo. Clin Cancer Res, 2008 Dec 18; 14(24). PMID: 19088015 Free PMC article. Review.
Confirmation of gene expression-based prediction of survival in non-small cell lung cancer. Nancy L Guo, Ying-Wooi Wan, +10 authors, Yong Qian. less Clin Cancer Res, 2008 Dec 18; 14(24). PMID: 19088038 Free PMC article.
Mechanisms of metastasis. Kent W Hunter, Nigel P S Crawford, Jude Alsarraj. Breast Cancer Res, 2009 Jan 06; 10 Suppl 1. PMID: 19091006 Free PMC article. Review.
Clinical impact of high-throughput gene expression studies in lung cancer. Jennifer Beane, Avrum Spira, Marc E Lenburg. J Thorac Oncol, 2008 Dec 20; 4(1). PMID: 19096318 Free PMC article. Review.
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Alexandra M Pietersen, Hugo M Horlings, +7 authors, Maarten van Lohuizen. less Breast Cancer Res, 2008 Dec 23; 10(6). PMID: 19099573 Free PMC article.
The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome. Jens K Habermann, Jana Doering, +12 authors, Thomas Ried. less Int J Cancer, 2008 Dec 23; 124(7). PMID: 19101988 Free PMC article.
Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer. Shigeto Ueda, Nobuo Kondoh, +10 authors, Hidetaka Mochizuki. less BMC Cancer, 2008 Dec 24; 8. PMID: 19102762 Free PMC article.
The origins of breast cancer prognostic gene expression profiles. Luanne Lukes, Nigel P S Crawford, Renard Walker, Kent W Hunter. Cancer Res, 2009 Jan 02; 69(1). PMID: 19118016 Free PMC article.
Recommendations from the EGAPP Working Group: can tumor gene expression profiling improve outcomes in patients with breast cancer? Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group. Genet Med, 2009 Jan 07; 11(1). PMID: 19125125 Free PMC article.
Markers of endocrine sensitivity. Daniel F Hayes. Breast Cancer Res, 2009 Jan 16; 10 Suppl 4. PMID: 19128431 Free PMC article.
The utility of conventional and molecular pathology in managing breast cancer. D Craig Allred. Breast Cancer Res, 2009 Jan 16; 10 Suppl 4. PMID: 19128442 Free PMC article.
Tailoring to RB: tumour suppressor status and therapeutic response. Erik S Knudsen, Karen E Knudsen. Nat Rev Cancer, 2009 Jan 15; 8(9). PMID: 19143056 Free PMC article. Highly Cited. Review.
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Ian W Taylor, Rune Linding, +7 authors, Jeffrey L Wrana. less Nat Biotechnol, 2009 Feb 03; 27(2). PMID: 19182785 Highly Cited.
Selecting control genes for RT-QPCR using public microarray data. Vlad Popovici, Darlene R Goldstein, +3 authors, Pratyaksha Wirapati. less BMC Bioinformatics, 2009 Feb 04; 10. PMID: 19187545 Free PMC article.
Development and Validation of Biomarker Classifiers for Treatment Selection. Richard Simon. J Stat Plan Inference, 2009 Feb 05; 138(2). PMID: 19190712 Free PMC article.
Molecular changes in primary breast tumors and the Nottingham Histologic Score. Rachel E Ellsworth, Jeffrey A Hooke, +2 authors, Brad Love, Darrell L Ellsworth, Craig D Shriver. less Pathol Oncol Res, 2009 Feb 06; 15(4). PMID: 19194786
Supervised risk predictor of breast cancer based on intrinsic subtypes. Joel S Parker, Michael Mullins, +17 authors, Philip S Bernard. less J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204204 Free PMC article. Highly Cited.
Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. Judith Hugh, John Hanson, +11 authors, Charles Vogel. less J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204205 Free PMC article. Highly Cited.
[Genome-wide expression profiling as a clinical tool: are we there yet?]. F C Geyer, T Decker, J S Reis-Filho. Pathologe, 2009 Feb 17; 30(2). PMID: 19219435 Review.
Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. Scott A Waldman, Terry Hyslop, +6 authors, David S Weinberg. less JAMA, 2009 Feb 20; 301(7). PMID: 19224751 Free PMC article.
Biological convergence of cancer signatures. Xavier Solé, Núria Bonifaci, +11 authors, Miguel Angel Pujana. less PLoS One, 2009 Feb 21; 4(2). PMID: 19229342 Free PMC article.
Genomancy: predicting tumour response to cancer therapy based on the oracle of genetics. P D Williams, J K Lee, D Theodorescu. Curr Oncol, 2009 Feb 21; 16(1). PMID: 19229372 Free PMC article.
Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer. A Anjomshoaa, Y-H Lin, +10 authors, A E Reeve. less Br J Cancer, 2009 Feb 25; 99(6). PMID: 19238634 Free PMC article.
Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer. M Loddo, S R Kingsbury, +10 authors, G H Williams. less Br J Cancer, 2009 Feb 26; 100(6). PMID: 19240714 Free PMC article.
Mutation detection by real-time PCR: a simple, robust and highly selective method. John Morlan, Joffre Baker, Dominick Sinicropi. PLoS One, 2009 Feb 26; 4(2). PMID: 19240792 Free PMC article.
Preservation of fertility in patients with cancer. Jacqueline S Jeruss, Teresa K Woodruff. N Engl J Med, 2009 Feb 28; 360(9). PMID: 19246362 Free PMC article. Highly Cited. Review.
Utilizing the molecular gateway: the path to personalized cancer management. Jonathan B Overdevest, Dan Theodorescu, Jae K Lee. Clin Chem, 2009 Feb 28; 55(4). PMID: 19246616 Free PMC article. Review.
Successful pregnancy after breast cancer therapy: dream or reality? Konstantinos Kontzoglou, Michael Stamatakos, +3 authors, Michael Safioleas. less Int Semin Surg Oncol, 2009 Mar 04; 6. PMID: 19254357 Free PMC article.
Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Dung-Tsa Chen, Aejaz Nasir, +12 authors, Timothy Yeatman. less Breast Cancer Res Treat, 2009 Mar 07; 119(2). PMID: 19266279 Free PMC article.
A radiation-derived gene expression signature predicts clinical outcome for breast cancer patients. Brian D Piening, Pei Wang, Aravind Subramanian, Amanda G Paulovich. Radiat Res, 2009 Mar 10; 171(2). PMID: 19267539 Free PMC article.
The tspair package for finding top scoring pair classifiers in R. Jeffrey T Leek. Bioinformatics, 2009 Mar 12; 25(9). PMID: 19276151 Free PMC article.
MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Sean P Pitroda, Nikolai N Khodarev, +2 authors, Michael A Beckett, Donald W Kufe, Ralph R Weichselbaum. less Proc Natl Acad Sci U S A, 2009 Mar 18; 106(14). PMID: 19289846 Free PMC article.
Factors influencing the statistical power of complex data analysis protocols for molecular signature development from microarray data. Constantin F Aliferis, Alexander Statnikov, +3 authors, Frank E Harrell. less PLoS One, 2009 Mar 18; 4(3). PMID: 19290050 Free PMC article.
A compact VEGF signature associated with distant metastases and poor outcomes. Zhiyuan Hu, Cheng Fan, +10 authors, Charles M Perou. less BMC Med, 2009 Mar 18; 7. PMID: 19291283 Free PMC article.
High cyclin B1 expression is associated with poor survival in breast cancer. K Aaltonen, R-M Amini, +4 authors, C Blomqvist. less Br J Cancer, 2009 Mar 19; 100(7). PMID: 19293801 Free PMC article.
Prevalence, morphologic features and proliferation indices of breast carcinoma molecular classes using immunohistochemical surrogate markers. Rohit Bhargava, Joan Striebel, +4 authors, David J Dabbs. less Int J Clin Exp Pathol, 2009 Mar 19; 2(5). PMID: 19294003 Free PMC article.
Prediction of breast cancer metastasis by genomic profiling: where do we stand? Ulrich Pfeffer, Francesco Romeo, Douglas M Noonan, Adriana Albini. Clin Exp Metastasis, 2009 Mar 25; 26(6). PMID: 19308665 Free PMC article. Review.
Transcriptome analysis of liver cancer: ready for the clinic? Xin Wei Wang, Snorri S Thorgeirsson. J Hepatol, 2009 Mar 31; 50(5). PMID: 19328580 Free PMC article.
A multi-marker assay to distinguish malignant melanomas from benign nevi. Mohammed Kashani-Sabet, Javier Rangel, +7 authors, Richard W Sagebiel. less Proc Natl Acad Sci U S A, 2009 Apr 01; 106(15). PMID: 19332774 Free PMC article.
Distant metastasis: not out of reach any more. François Bertucci, Daniel Birnbaum. J Biol, 2009 Apr 07; 8(3). PMID: 19344492 Free PMC article. Review.
Breaking down barriers: the importance of the stromal microenvironment in acquiring invasiveness in young women's breast cancer. Pepper Schedin, Virginia Borges. Breast Cancer Res, 2009 Apr 07; 11(2). PMID: 19344495 Free PMC article.
Gene expression profiles and breast cancer metastasis: a genetic perspective. Kent W Hunter, Jude Alsarraj. Clin Exp Metastasis, 2009 Apr 07; 26(6). PMID: 19347591 Free PMC article. Review.
Genomics of lung cancer. Alain C Borczuk, Rebecca L Toonkel, Charles A Powell. Proc Am Thorac Soc, 2009 Apr 08; 6(2). PMID: 19349483 Free PMC article. Review.
Quantitative assessment of tissue biomarkers and construction of a model to predict outcome in breast cancer using multiple imputation. John W Emerson, Marisa Dolled-Filhart, +2 authors, Lyndsay Harris, David L Rimm, David P Tuck. less Cancer Inform, 2009 Apr 09; 7. PMID: 19352457 Free PMC article.
A health services research agenda for cellular, molecular and genomic technologies in cancer care. Louise Wideroff, Kathryn A Phillips, +16 authors, Joan Scott. less Public Health Genomics, 2009 Apr 16; 12(4). PMID: 19367091 Free PMC article. Review.
Molecular classification of solid tumours: towards pathway-driven therapeutics. C Swanton, C Caldas. Br J Cancer, 2009 Apr 16; 100(10). PMID: 19367275 Free PMC article. Review.
Metastatic gene signatures and emerging novel prognostic tests in the management of early stage breast cancer. Attila Tordai, Cornelia Liedtke, Lajos Pusztai. Clin Exp Metastasis, 2009 Apr 22; 26(7). PMID: 19381845 Review.
The MINDACT trial: the first prospective clinical validation of a genomic tool. Fatima Cardoso, Martine Piccart-Gebhart, +2 authors, Laura Van't Veer, Emiel Rutgers, TRANSBIG Consortium. less Mol Oncol, 2007 Dec 01; 1(3). PMID: 19383299 Free PMC article.
Biomarkers in oncology drug development. Darren R Hodgson, Robin D Whittaker, +2 authors, Athula Herath, Dereck Amakye, Glen Clack. less Mol Oncol, 2009 Apr 23; 3(1). PMID: 19383364 Free PMC article. Review.
Targeted proteomic strategy for clinical biomarker discovery. Ralph Schiess, Bernd Wollscheid, Ruedi Aebersold. Mol Oncol, 2009 Apr 23; 3(1). PMID: 19383365 Free PMC article. Highly Cited. Review.
Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer. Rou Wang, David S Morris, +8 authors, Arul M Chinnaiyan. less Cancer Res, 2009 Apr 23; 69(9). PMID: 19383904 Free PMC article.
Molecular characterization of apocrine carcinoma of the breast: validation of an apocrine protein signature in a well-defined cohort. Julio E Celis, Teresa Cabezón, +7 authors, Fritz Rank. less Mol Oncol, 2009 Apr 28; 3(3). PMID: 19393583 Free PMC article.
Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma. Gavin J Gordon, Lingsheng Dong, +9 authors, Raphael Bueno. less J Natl Cancer Inst, 2009 Apr 30; 101(9). PMID: 19401544 Free PMC article.
Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer. Jocelyne Jacquemier, Emmanuelle Charafe-Jauffret, +6 authors, Daniel Birnbaum. less Breast Cancer Res, 2009 May 02; 11(2). PMID: 19405945 Free PMC article.
Genomic and proteomic biomarkers for cancer: a multitude of opportunities. Michael A Tainsky. Biochim Biophys Acta, 2009 May 02; 1796(2). PMID: 19406210 Free PMC article. Review.
Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment. John H Phan, Richard A Moffitt, +4 authors, May D Wang. less Trends Biotechnol, 2009 May 05; 27(6). PMID: 19409634 Free PMC article. Review.
Recent advances in systemic therapy: new diagnostics and biological predictors of outcome in early breast cancer. Catherine Oakman, Silvia Bessi, +3 authors, Angelo Di Leo. less Breast Cancer Res, 2009 May 14; 11(2). PMID: 19435470 Free PMC article. Review.
Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. Maggie C U Cheang, Stephen K Chia, +10 authors, Torsten O Nielsen. less J Natl Cancer Inst, 2009 May 14; 101(10). PMID: 19436038 Free PMC article. Highly Cited.
The role of cathepsins in involution and breast cancer. Christine J Watson, Peter A Kreuzaler. J Mammary Gland Biol Neoplasia, 2009 May 14; 14(2). PMID: 19437107
Effects of sample size on robustness and prediction accuracy of a prognostic gene signature. Seon-Young Kim. BMC Bioinformatics, 2009 May 19; 10. PMID: 19445687 Free PMC article.
Challenges in the analysis of mass-throughput data: a technical commentary from the statistical machine learning perspective. Constantin F Aliferis, Alexander Statnikov, Ioannis Tsamardinos. Cancer Inform, 2007 Jan 01; 2. PMID: 19458765 Free PMC article.
Detecting outlier microarray arrays by correlation and percentage of outliers spots. Song Yang, Xiang Guo, +6 authors, Hai Hu. less Cancer Inform, 2007 Jan 01; 2. PMID: 19458777 Free PMC article.
Expression of ER-{alpha}36, a novel variant of estrogen receptor {alpha}, and resistance to tamoxifen treatment in breast cancer. Liang Shi, Bin Dong, +9 authors, Yuntao Xie. less J Clin Oncol, 2009 Jun 03; 27(21). PMID: 19487384 Free PMC article.
Gene expression-based prognostic and predictive markers for breast cancer: a primer for practicing pathologists. Chungyeul Kim, Yusuke Taniyama, Soonmyung Paik. Arch Pathol Lab Med, 2009 Jun 06; 133(6). PMID: 19492877 Free PMC article. Review.
A longitudinal study of gene expression in healthy individuals. Chris Karlovich, Guillemette Duchateau-Nguyen, +8 authors, John P Caulfield. less BMC Med Genomics, 2009 Jun 09; 2. PMID: 19500411 Free PMC article.
STAT1 pathway mediates amplification of metastatic potential and resistance to therapy. Nikolai N Khodarev, Paul Roach, +11 authors, Ralph R Weichselbaum. less PLoS One, 2009 Jun 09; 4(6). PMID: 19503789 Free PMC article.
Genomic predictors of outcome and treatment response in breast cancer. Lara Dunn, Angela Demichele. Mol Diagn Ther, 2009 Jun 23; 13(2). PMID: 19537843 Review.
Comparison of prognostic gene profiles using qRT-PCR in paraffin samples: a retrospective study in patients with early breast cancer. Enrique Espinosa, Iker Sánchez-Navarro, +9 authors, Juan Angel Fresno Vara. less PLoS One, 2009 Jun 24; 4(6). PMID: 19547727 Free PMC article.
Verification of a prolonged untreated natural history of breast cancer by the multigene assay. Tadeja Urbas, Neal Agee, Marcia E Bouton, Ian K Komenaka. Med Oncol, 2009 Jun 24; 27(3). PMID: 19548125
Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer. Sherene Loi, Christos Sotiriou, +5 authors, Grant A McArthur. less BMC Med Genomics, 2009 Jun 26; 2. PMID: 19552798 Free PMC article.
A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity. Brooke L Fridley, Gregory Jenkins, Daniel J Schaid, Liewei Wang. Stat Med, 2009 Jul 03; 28(21). PMID: 19572260 Free PMC article.
Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. Adedayo A Onitilo, Jessica M Engel, Robert T Greenlee, Bickol N Mukesh. Clin Med Res, 2009 Jul 04; 7(1-2). PMID: 19574486 Free PMC article. Highly Cited.
Current molecular diagnostics of breast cancer and the potential incorporation of microRNA. Christine K Zoon, Elizabeth Q Starker, +3 authors, Michael A Tangrea. less Expert Rev Mol Diagn, 2009 Jul 08; 9(5). PMID: 19580430 Free PMC article. Review.
Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis. Mi Jeong Kwon, Ensel Oh, +8 authors, Young Kee Shin. less PLoS One, 2009 Jul 09; 4(7). PMID: 19584937 Free PMC article.
Postoperative endocrine therapy for invasive breast cancer. Leisha A Emens, Nancy E Davidson. Cancer Treat Res, 2009 Jul 14; 151. PMID: 19593511 Free PMC article. Review.
Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. Sumithra J Mandrekar, Daniel J Sargent. J Clin Oncol, 2009 Jul 15; 27(24). PMID: 19597023 Free PMC article. Highly Cited.
Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer. Steven Buechler. BMC Cancer, 2009 Jul 22; 9. PMID: 19619298 Free PMC article.
Genomic advances and their impact on clinical trial design. Sumithra J Mandrekar, Daniel J Sargent. Genome Med, 2009 Jul 30; 1(7). PMID: 19638184 Free PMC article.
MicroRNAs as Novel Biomarkers for Breast Cancer. H M Heneghan, N Miller, +2 authors, A J Lowery, K J Sweeney, M J Kerin. less J Oncol, 2009 Jul 30; 2009. PMID: 19639033 Free PMC article.
Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology. Christine L H Snozek, Dennis J O'Kane, Alicia Algeciras-Schimnich. J Mol Diagn, 2009 Aug 01; 11(5). PMID: 19644023 Free PMC article. Review.
Evaluation of microtubule-associated protein-Tau expression as a prognostic and predictive marker in the NSABP-B 28 randomized clinical trial. Lajos Pusztai, Jong-Hyeon Jeong, +8 authors, W Fraser Symmans. less J Clin Oncol, 2009 Aug 12; 27(26). PMID: 19667268 Free PMC article.
Mechanisms and pathways of bone metastasis: challenges and pitfalls of performing molecular research on patient samples. T R Cawthorn, E Amir, +7 authors, M Clemons. less Clin Exp Metastasis, 2009 Aug 22; 26(8). PMID: 19697143
Analysis of DNA microarray expression data. Richard Simon. Best Pract Res Clin Haematol, 2009 Aug 25; 22(2). PMID: 19698933 Free PMC article.
Biological determinants of endocrine resistance in breast cancer. Elizabeth A Musgrove, Robert L Sutherland. Nat Rev Cancer, 2009 Aug 25; 9(9). PMID: 19701242 Highly Cited. Review.
Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer. Y Nadler, A M González, +3 authors, R L Camp, D L Rimm, H M Kluger, Y Kluger. less Ann Oncol, 2009 Sep 01; 21(3). PMID: 19717535 Free PMC article.
Genetic characterization of breast cancer and implications for clinical management. Felipe C Geyer, Maria A Lopez-Garcia, Maryou B Lambros, Jorge S Reis-Filho. J Cell Mol Med, 2009 Sep 17; 13(10). PMID: 19754664 Free PMC article. Review.
Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression. Shannon N Westin, Russell R Broaddus, +8 authors, David S Loose. less Cancer biology & therapy, 2009 Sep 17; 8(22). PMID: 19755863 Free PMC article.
PAPAyA: a platform for breast cancer biomarker signature discovery, evaluation and assessment. Angel Janevski, Sitharthan Kamalakaran, +2 authors, Nilanjana Banerjee, Vinay Varadan, Nevenka Dimitrova. less BMC Bioinformatics, 2009 Sep 26; 10 Suppl 9. PMID: 19761577 Free PMC article.
Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells. Shanaz H Dairkee, Aejaz Sayeed, +6 authors, Dan H Moore. less Cancer Res, 2009 Oct 01; 69(19). PMID: 19789341 Free PMC article.
Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applications. Lap Ho, Hayley Fivecoat, Jun Wang, Giulio Maria Pasinetti. Exp Gerontol, 2009 Oct 03; 45(1). PMID: 19796674 Free PMC article. Review.
Making the case for molecular staging of malignant pleural mesothelioma. Raphael Bueno. Semin Thorac Cardiovasc Surg, 2009 Oct 14; 21(2). PMID: 19822292 Free PMC article. Review.
Preinvasive breast cancer. Dennis C Sgroi. Annu Rev Pathol, 2009 Oct 15; 5. PMID: 19824828 Free PMC article. Review.
Prognostic and predictive factors and genetic analysis of early breast cancer. Miguel Martín, Fernando González Palacios, +2 authors, Javier Cortés, Juan de la Haba, José Schneider. less Clin Transl Oncol, 2009 Oct 16; 11(10). PMID: 19828405 Review.
A multi-center phase II evaluation of the small molecule survivin suppressor YM155 in patients with unresectable stage III or IV melanoma. Karl D Lewis, Wolfram Samlowski, +6 authors, Rene Gonzalez. less Invest New Drugs, 2009 Oct 16; 29(1). PMID: 19830389
Gene expression profile assays as predictors of distant recurrence-free survival in early-stage breast cancer. Nicole M Kuderer, Gary H Lyman. Cancer Invest, 2009 Oct 17; 27(9). PMID: 19832034 Free PMC article. Review.
A 7 gene expression score predicts for radiation response in cancer cervix. Thangarajan Rajkumar, Neelakantan Vijayalakshmi, +4 authors, Lavanya Nambaru. less BMC Cancer, 2009 Oct 17; 9. PMID: 19832977 Free PMC article.
Melanoma prognostic model using tissue microarrays and genetic algorithms. Bonnie E Gould Rothberg, Aaron J Berger, +7 authors, David L Rimm. less J Clin Oncol, 2009 Nov 04; 27(34). PMID: 19884546 Free PMC article.
Breast cancer in young women: poor survival despite intensive treatment. Hanna Fredholm, Sonja Eaker, +3 authors, Henrik Lindman. less PLoS One, 2009 Nov 13; 4(11). PMID: 19907646 Free PMC article. Highly Cited.
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. J Joshua Smith, Natasha G Deane, +16 authors, R Daniel Beauchamp. less Gastroenterology, 2009 Nov 17; 138(3). PMID: 19914252 Free PMC article. Highly Cited.
Adjuvant endocrine therapy for premenopausal women with breast cancer. Shannon Puhalla, Adam Brufsky, Nancy Davidson. Breast, 2009 Nov 17; 18 Suppl 3. PMID: 19914530 Free PMC article. Review.
Impact of biospecimens handling on biomarker research in breast cancer. Loris De Cecco, Valeria Musella, +6 authors, Maria Grazia Daidone. less BMC Cancer, 2009 Nov 26; 9. PMID: 19930681 Free PMC article.
Evaluation of Oncotype DX Recurrence Score as a prognostic factor in Japanese women with estrogen receptor-positive, node-negative primary Stage I or IIA breast cancer. Kyoko Yorozuya, Toru Takeuchi, +9 authors, Shogo Kikuchi. less J Cancer Res Clin Oncol, 2009 Dec 01; 136(6). PMID: 19946706
[Beyond staging, typing and grading. New challenges in breast cancer pathology]. H H Kreipe, P Ahrens, +2 authors, M Christgen, U Lehmann, F Länger. less Pathologe, 2009 Dec 02; 31(1). PMID: 19949797 Review.
Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer. Joseph A Sparano, Lori J Goldstein, +12 authors, Robert Gray. less Clin Cancer Res, 2009 Dec 10; 15(24). PMID: 19996222 Free PMC article.
Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer. Philippe L Bedard, Angelo Di Leo, Martine J Piccart-Gebhart. Nat Rev Clin Oncol, 2009 Dec 10; 7(1). PMID: 19997076 Review.
Survival prediction from clinico-genomic models--a comparative study. Hege M Bøvelstad, Ståle Nygård, Ornulf Borgan. BMC Bioinformatics, 2009 Dec 17; 10. PMID: 20003386 Free PMC article.
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Kathy S Albain, William E Barlow, +20 authors, Breast Cancer Intergroup of North America. less Lancet Oncol, 2009 Dec 17; 11(1). PMID: 20005174 Free PMC article. Highly Cited.
Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Francisco J Esteva, Dihua Yu, Mien-Chie Hung, Gabriel N Hortobagyi. Nat Rev Clin Oncol, 2009 Dec 23; 7(2). PMID: 20027191 Review.
Radiation impact in breast cancer. Joseph Ragaz. Breast Cancer Res, 2010 Jan 20; 11 Suppl 3. PMID: 20030865 Free PMC article. Review.
Tailored targeted therapy for all: a realistic and worthwhile objective against. Kathleen I Pritchard. Breast Cancer Res, 2010 Jan 20; 11 Suppl 3. PMID: 20030883 Free PMC article.
Application of RT-PCR in formalin-fixed and paraffin-embedded lung cancer tissues. Fan Zhang, Zhuo-min Wang, +6 authors, Qing-hua Zhou. less Acta Pharmacol Sin, 2009 Dec 29; 31(1). PMID: 20037605 Free PMC article.
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Multidisciplinary approach of early breast cancer: the biology applied to radiation oncology. Céline Bourgier, Mahmut Ozsahin, David Azria. Radiat Oncol, 2010 Jan 16; 5. PMID: 20074364 Free PMC article. Review.
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A population-based gene signature is predictive of breast cancer survival and chemoresponse. Shruti Rathnagiriswaran, Ying-Wooi Wan, +3 authors, Nancy L Guo. less Int J Oncol, 2010 Feb 04; 36(3). PMID: 20126981 Free PMC article.
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. Patricia J Hunter, Kiran Nistala, +4 authors, Lucy R Wedderburn. less Arthritis Rheum, 2010 Feb 04; 62(3). PMID: 20127724 Free PMC article.
MYC regulation of a "poor-prognosis" metastatic cancer cell state. Anita Wolfer, Ben S Wittner, +14 authors, Sridhar Ramaswamy. less Proc Natl Acad Sci U S A, 2010 Feb 06; 107(8). PMID: 20133671 Free PMC article.
Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue. Janine Antonov, Vlad Popovici, +9 authors, Rolf Jaggi. less BMC Cancer, 2010 Feb 11; 10. PMID: 20144231 Free PMC article.
A multigene predictor of outcome in glioblastoma. Howard Colman, Li Zhang, +16 authors, Ken Aldape. less Neuro Oncol, 2010 Feb 13; 12(1). PMID: 20150367 Free PMC article. Highly Cited.
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Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus. Yihong Yao, Brandon W Higgs, +2 authors, Laura Richman, Barbara White, Bahija Jallal. less Arthritis Res Ther, 2010 Apr 16; 12 Suppl 1. PMID: 20392292 Free PMC article. Review.
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Use of ER/PR/HER2 subtypes in conjunction with the 2007 St Gallen Consensus Statement for early breast cancer. Katrina Bauer, Carol Parise, Vincent Caggiano. BMC Cancer, 2010 May 25; 10. PMID: 20492696 Free PMC article.
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An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer. Iker Sánchez-Navarro, Angelo Gámez-Pozo, +11 authors, Enrique Espinosa. less BMC Cancer, 2010 Jun 30; 10. PMID: 20584321 Free PMC article.
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Ferroportin and iron regulation in breast cancer progression and prognosis. Zandra K Pinnix, Lance D Miller, +9 authors, Frank M Torti. less Sci Transl Med, 2010 Aug 06; 2(43). PMID: 20686179 Free PMC article. Highly Cited.
The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines. Kristina Subik, Jin-Feng Lee, +8 authors, Ping Tang. less Breast Cancer (Auckl), 2010 Aug 11; 4. PMID: 20697531 Free PMC article. Highly Cited.
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Tumor profiling: development of prognostic and predictive factors to guide brain tumor treatment. Stephen H Settle, Erik P Sulman. Curr Oncol Rep, 2010 Nov 18; 13(1). PMID: 21082294 Review.
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Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. Andrew J Gentles, Sylvia K Plevritis, Ravindra Majeti, Ash A Alizadeh. JAMA, 2010 Dec 24; 304(24). PMID: 21177505 Free PMC article. Highly Cited.
Coverage policy development for personalized medicine: private payer perspectives on developing policy for the 21-gene assay. Julia R Trosman, Stephanie L Van Bebber, Kathryn A Phillips. J Oncol Pract, 2011 Jan 05; 6(5). PMID: 21197187 Free PMC article.
Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning. Min Yi, Thomas A Buchholz, +12 authors, Kelly K Hunt. less Ann Surg, 2011 Jan 07; 253(3). PMID: 21209588 Free PMC article.
The tumor microenvironment in colorectal carcinogenesis. Vijay G Peddareddigari, Dingzhi Wang, Raymond N Dubois. Cancer Microenviron, 2011 Jan 07; 3(1). PMID: 21209781 Free PMC article.
Postoperative fever: the potential relationship with prognosis in node negative breast cancer patients. Tingting Yan, Wenjin Yin, +4 authors, Jinsong Lu. less PLoS One, 2011 Jan 07; 5(12). PMID: 21209958 Free PMC article.
Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures. Cheng Fan, Aleix Prat, +4 authors, Charles M Perou. less BMC Med Genomics, 2011 Jan 11; 4. PMID: 21214954 Free PMC article.
Risk of a second breast cancer associated with hormone-receptor and HER2/neu status of the first breast cancer. Leona Bessonova, Thomas H Taylor, +2 authors, Rita S Mehta, Jason A Zell, Hoda Anton-Culver. less Cancer Epidemiol Biomarkers Prev, 2011 Jan 11; 20(2). PMID: 21217087 Free PMC article.
Comparison of the prognostic and predictive utilities of the 21-gene Recurrence Score assay and Adjuvant! for women with node-negative, ER-positive breast cancer: results from NSABP B-14 and NSABP B-20. Gong Tang, Steven Shak, +6 authors, Norman Wolmark. less Breast Cancer Res Treat, 2011 Jan 12; 127(1). PMID: 21221771 Free PMC article.
Young age, increased tumor proliferation and FOXM1 expression predict early metastatic relapse only for endocrine-dependent breast cancers. Christina Yau, Yixin Wang, +2 authors, Yi Zhang, John A Foekens, Christopher C Benz. less Breast Cancer Res Treat, 2011 Jan 13; 126(3). PMID: 21225456 Free PMC article.
High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Laura Gonzalez-Malerva, Jaehong Park, +7 authors, Joshua LaBaer. less Proc Natl Acad Sci U S A, 2011 Jan 15; 108(5). PMID: 21233418 Free PMC article.
Meningeal carcinomatosis in breast cancer: prognostic factors and outcome. Carla Rameri Alexandre Silva de Azevedo, Marcelo Rocha Sousa Cruz, +5 authors, Daniel Luiz Gimenes. less J Neurooncol, 2011 Jan 15; 104(2). PMID: 21234642
Incorporating fertility preservation into the care of young oncology patients. Amanda J Redig, Robert Brannigan, +2 authors, Steven J Stryker, Teresa K Woodruff, Jacqueline S Jeruss. less Cancer, 2011 Jan 15; 117(1). PMID: 21235031 Free PMC article.
A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment. Steven Christopher Smith, Alexander Spyridon Baras, +9 authors, Dan Theodorescu. less Lancet Oncol, 2011 Jan 25; 12(2). PMID: 21256081 Free PMC article.
Confident predictability: identifying reliable gene expression patterns for individualized tumor classification using a local minimax kernel algorithm. Lee K Jones, Fei Zou, +3 authors, Aik Choon Tan. less BMC Med Genomics, 2011 Jan 26; 4. PMID: 21261972 Free PMC article.
Breast cancer and fertility preservation. S Samuel Kim, Jennifer Klemp, Carol Fabian. Fertil Steril, 2011 Jan 29; 95(5). PMID: 21272867 Free PMC article. Review.
Physical and psychosocial recovery in the year after primary treatment of breast cancer. Patricia A Ganz, Lorna Kwan, +2 authors, Annette L Stanton, Julienne E Bower, Thomas R Belin. less J Clin Oncol, 2011 Feb 09; 29(9). PMID: 21300931 Free PMC article.
Diabetes and biomarkers. Erica J Caveney, Oren J Cohen. J Diabetes Sci Technol, 2011 Feb 10; 5(1). PMID: 21303644 Free PMC article.
Charting a course for genomic medicine from base pairs to bedside. Eric D Green, Mark S Guyer, National Human Genome Research Institute. Nature, 2011 Feb 11; 470(7333). PMID: 21307933 Highly Cited.
A four-gene signature predicts disease progression in muscle invasive bladder cancer. Wun-Jae Kim, Seon-Kyu Kim, +6 authors, Yung Hyun Choi. less Mol Med, 2011 Feb 11; 17(5-6). PMID: 21308147 Free PMC article.
Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study. Jack Cuzick, Gregory P Swanson, +18 authors, Transatlantic Prostate Group. less Lancet Oncol, 2011 Feb 12; 12(3). PMID: 21310658 Free PMC article. Highly Cited.
Par genes: molecular probes to pathological assessment in breast cancer progression. Beatrice Uziely, Hagit Turm, +3 authors, Myriam Maoz, Irit Cohen, Bella Maly, Rachel Bar-Shavit. less Patholog Res Int, 2011 Feb 15; 2011. PMID: 21318117 Free PMC article.
Small-molecule protein kinase inhibitors and their effects on the immune system: implications for cancer treatment. Patrick A Ott, Sylvia Adams. Immunotherapy, 2011 Feb 17; 3(2). PMID: 21322760 Free PMC article. Review.
Challenges to developing proteomic-based breast cancer diagnostics. Richard R Drake, Lisa H Cazares, +3 authors, Christine Laronga. less OMICS, 2011 Feb 22; 15(5). PMID: 21332380 Free PMC article. Review.
Gene signatures of breast cancer progression and metastasis. David I Rodenhiser, Joseph D Andrews, Theodore A Vandenberg, Ann F Chambers. Breast Cancer Res, 2011 Feb 25; 13(1). PMID: 21345283 Free PMC article. Review.
Gene List significance at-a-glance with GeneValorization. Bryan Brancotte, Anne Biton, +3 authors, Sarah Cohen-Boulakia. less Bioinformatics, 2011 Feb 26; 27(8). PMID: 21349868 Free PMC article.
Can some patients avoid adjuvant chemotherapy for early-stage breast cancer? Philippe L Bedard, Fatima Cardoso. Nat Rev Clin Oncol, 2011 Mar 03; 8(5). PMID: 21364525 Review.
Methodological and practical challenges for personalized cancer therapies. Ignacio I Wistuba, Juri G Gelovani, +2 authors, Jörg J Jacoby, Suzanne E Davis, Roy S Herbst. less Nat Rev Clin Oncol, 2011 Mar 03; 8(3). PMID: 21364686 Review.
Taming the dragon: genomic biomarkers to individualize the treatment of cancer. Ian J Majewski, René Bernards. Nat Med, 2011 Mar 10; 17(3). PMID: 21386834
Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression. Xuyu Zu, Jun Ma, +7 authors, Yuyang Jiang. less Breast Cancer Res, 2011 Mar 12; 13(2). PMID: 21392388 Free PMC article.
Making sense of cancer genomic data. Lynda Chin, William C Hahn, Gad Getz, Matthew Meyerson. Genes Dev, 2011 Mar 17; 25(6). PMID: 21406553 Free PMC article. Highly Cited. Review.
Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples. J S Hall, H S Leong, +8 authors, C M L West. less Br J Cancer, 2011 Mar 17; 104(6). PMID: 21407225 Free PMC article.
Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement. Alan Mackay, Britta Weigelt, +7 authors, Jorge S Reis-Filho. less J Natl Cancer Inst, 2011 Mar 23; 103(8). PMID: 21421860 Free PMC article.
Do two machine-learning based prognostic signatures for breast cancer capture the same biological processes? Yotam Drier, Eytan Domany. PLoS One, 2011 Mar 23; 6(3). PMID: 21423753 Free PMC article.
Combining gene signatures improves prediction of breast cancer survival. Xi Zhao, Einar Andreas Rødland, +6 authors, Ole Christian Lingjærde. less PLoS One, 2011 Mar 23; 6(3). PMID: 21423775 Free PMC article.
Breast cancer methylomes establish an epigenomic foundation for metastasis. Fang Fang, Sevin Turcan, +15 authors, Timothy A Chan. less Sci Transl Med, 2011 Mar 25; 3(75). PMID: 21430268 Free PMC article. Highly Cited.
Prognostic significance of TRIM24/TIF-1α gene expression in breast cancer. Monique Chambon, Béatrice Orsetti, +8 authors, Vincent Cavaillès. less Am J Pathol, 2011 Mar 26; 178(4). PMID: 21435435 Free PMC article.
Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients. Michael R Elashoff, James A Wingrove, +13 authors, Eric J Topol. less BMC Med Genomics, 2011 Mar 30; 4. PMID: 21443790 Free PMC article.
GOBO: gene expression-based outcome for breast cancer online. Markus Ringnér, Erik Fredlund, +2 authors, Jari Häkkinen, Åke Borg, Johan Staaf. less PLoS One, 2011 Mar 30; 6(3). PMID: 21445301 Free PMC article. Highly Cited.
Gene expression signature-based prognostic risk score in gastric cancer. Jae Yong Cho, Jae Yun Lim, +13 authors, Ju-Seog Lee. less Clin Cancer Res, 2011 Mar 31; 17(7). PMID: 21447720 Free PMC article. Highly Cited.
E2F1 and KIAA0191 expression predicts breast cancer patient survival. Robin M Hallett, John A Hassell. BMC Res Notes, 2011 Apr 02; 4. PMID: 21453498 Free PMC article.
Biomarker discovery using statistically significant gene sets. Hoon Kim, John Watkinson, Dimitris Anastassiou. J Comput Biol, 2011 Apr 05; 18(10). PMID: 21457009 Free PMC article.
Design and multiseries validation of a web-based gene expression assay for predicting breast cancer recurrence and patient survival. Ryan K Van Laar. J Mol Diagn, 2011 Apr 05; 13(3). PMID: 21458382 Free PMC article.
Mass spectrometric characterization of protein structure details refines the proteome signature for invasive ductal breast carcinoma. Claudia Röwer, Cornelia Koy, +4 authors, Michael O Glocker. less J Am Soc Mass Spectrom, 2011 Apr 08; 22(3). PMID: 21472563
miRNA Biomarkers in Breast Cancer Detection and Management. Sidney W Fu, Liang Chen, Yan-Gao Man. J Cancer, 2011 Apr 12; 2. PMID: 21479130 Free PMC article.
Examining the influence of beta blockers and ACE inhibitors on the risk for breast cancer recurrence: results from the LACE cohort. Patricia A Ganz, Laurel A Habel, +2 authors, Erin K Weltzien, Bette J Caan, Steven W Cole. less Breast Cancer Res Treat, 2011 Apr 12; 129(2). PMID: 21479924 Free PMC article.
Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6×FEC versus 3×FEC/3×Docetaxel. Eva J Kantelhardt, Martina Vetter, +12 authors, Nadia Harbeck. less BMC Cancer, 2011 Apr 19; 11. PMID: 21496284 Free PMC article.
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. Kuo-Jang Kao, Kai-Ming Chang, Hui-Chi Hsu, Andrew T Huang. BMC Cancer, 2011 Apr 20; 11. PMID: 21501481 Free PMC article. Highly Cited.
Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes. Marina Pajic, Christopher J Scarlett, +2 authors, David K Chang, Robert L Sutherland, Andrew V Biankin. less Hum Genet, 2011 Apr 26; 130(1). PMID: 21516344 Review.
Metastasis-suppressor genes in clinical practice: lost in translation? Alexander N Shoushtari, Russell Z Szmulewitz, Carrie W Rinker-Schaeffer. Nat Rev Clin Oncol, 2011 Apr 28; 8(6). PMID: 21522123 Review.
Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications. Taru A Muranen, Dario Greco, +7 authors, Heli Nevanlinna. less Breast Cancer Res, 2011 May 06; 13(5). PMID: 21542898 Free PMC article.
mRNA transcript quantification in archival samples using multiplexed, color-coded probes. Patricia P Reis, Levi Waldron, +7 authors, Suzanne Kamel-Reid. less BMC Biotechnol, 2011 May 10; 11. PMID: 21549012 Free PMC article. Highly Cited.
Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection. Carmen Criscitiello, Debora Fumagalli, Kamal S Saini, Sherene Loi. Onco Targets Ther, 2011 May 10; 4. PMID: 21552410 Free PMC article.
Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype--ACOSOG Z1031. Matthew J Ellis, Vera J Suman, +17 authors, John A Olson. less J Clin Oncol, 2011 May 11; 29(17). PMID: 21555689 Free PMC article. Highly Cited.
Breast cancer adjuvant therapy: time to consider its time-dependent effects. Ismail Jatoi, William F Anderson, Jong-Hyeon Jeong, Carol K Redmond. J Clin Oncol, 2011 May 11; 29(17). PMID: 21555693 Free PMC article.
Prognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial. P-L Jerevall, X-J Ma, +9 authors, O Stål. less Br J Cancer, 2011 May 12; 104(11). PMID: 21559019 Free PMC article.
A multimarker QPCR-based platform for the detection of circulating tumour cells in patients with early-stage breast cancer. T J Molloy, L A Devriese, +5 authors, L J van't Veer. less Br J Cancer, 2011 May 19; 104(12). PMID: 21587256 Free PMC article.
Biologic markers determine both the risk and the timing of recurrence in breast cancer. Laura J Esserman, Dan H Moore, +11 authors, Christopher C Benz. less Breast Cancer Res Treat, 2011 May 21; 129(2). PMID: 21597921 Free PMC article.
Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer. Simpa S Salami, Folke Schmidt, +10 authors, Martin G Sanda. less Urol Oncol, 2011 May 24; 31(5). PMID: 21600800 Free PMC article.
Innovations in chemotherapy and radiation therapy: Implications and opportunities for the Asia-Pacific Rim. D E Heron, J E Shogan, J W Mucenski. Biomed Imaging Interv J, 2008 Jul 01; 4(3). PMID: 21611006 Free PMC article.
A tri-marker proliferation index predicts biochemical recurrence after surgery for prostate cancer. Sameer Malhotra, Jacques Lapointe, +6 authors, Jonathan R Pollack. less PLoS One, 2011 Jun 02; 6(5). PMID: 21629784 Free PMC article.
Adjuvant chemotherapy for breast cancer in older women: emerging evidence to aid in decision making. Gretchen Kimmick. Curr Treat Options Oncol, 2011 Jun 04; 12(3). PMID: 21638199 Review.
A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology. J Keith Killian, Sven Bilke, +8 authors, Paul S Meltzer. less Am J Pathol, 2011 Jun 07; 179(1). PMID: 21641572 Free PMC article.
Protein expression based multimarker analysis of breast cancer samples. Angela P Presson, Nam K Yoon, +7 authors, Steve Horvath. less BMC Cancer, 2011 Jun 10; 11. PMID: 21651811 Free PMC article.
Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. Yuh-Charn Lin, Chun-Chuan Chen, Chien-Jui Cheng, Ruey-Bing Yang. J Biol Chem, 2011 Jun 10; 286(30). PMID: 21652720 Free PMC article.
Emerging tactical strategies for fighting the war on cancer based on the genetic landscape. Peter D Burbelo, Kathryn H Ching, Kathleen E Bren, Michael J Iadarola. Am J Transl Res, 2011 Jun 10; 3(3). PMID: 21654880 Free PMC article.
Right-side and left-side colon cancer follow different pathways to relapse. Kerry M Bauer, Amanda B Hummon, Steven Buechler. Mol Carcinog, 2011 Jun 10; 51(5). PMID: 21656576 Free PMC article.
Global profiling of signaling networks: study of breast cancer stem cells and potential regulation. Hongxia Wang, Mingzhu Huang, David Y Zhang, Fengchun Zhang. Oncologist, 2011 Jun 15; 16(7). PMID: 21665913 Free PMC article.
The changing role of pathology in breast cancer diagnosis and treatment. Anthony S-Y Leong, Zhengping Zhuang. Pathobiology, 2011 Jun 17; 78(2). PMID: 21677473 Free PMC article. Review.
Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens. Al Muktafi Sadi, Dong-Yu Wang, +4 authors, Wey L Leong. less BMC Cancer, 2011 Jun 18; 11. PMID: 21679412 Free PMC article.
Gene expression profile testing for breast cancer and the use of chemotherapy, serious adverse effects, and costs of care. Jennifer S Haas, Su-Ying Liang, +3 authors, Kathryn A Phillips. less Breast Cancer Res Treat, 2011 Jun 18; 130(2). PMID: 21681446 Free PMC article.
A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Bryan T Hennessy, Yiling Lu, +18 authors, Gordon B Mills. less Clin Proteomics, 2011 Jun 22; 6(4). PMID: 21691416 Free PMC article. Highly Cited.
Gene expression analysis characterizes antemortem stress and has implications for establishing cause of death. David Jardine, Leanne Cornel, Mary Emond. Physiol Genomics, 2011 Jun 23; 43(16). PMID: 21693618 Free PMC article.
TFRC and ACTB as the best reference genes to quantify Urokinase Plasminogen Activator in breast cancer. Keivan Majidzadeh-A, Rezvan Esmaeili, Nasrin Abdoli. BMC Res Notes, 2011 Jun 28; 4. PMID: 21702980 Free PMC article.
Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki-67 and p53. E K A Millar, P H Graham, +10 authors, R L Sutherland. less Br J Cancer, 2011 Jun 30; 105(2). PMID: 21712826 Free PMC article.
Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples. Fathi Elloumi, Zhiyuan Hu, +4 authors, Melissa A Troester. less BMC Med Genomics, 2011 Jul 02; 4. PMID: 21718502 Free PMC article.
Physician survey of the effect of the 21-gene recurrence score assay results on treatment recommendations for patients with lymph node-positive, estrogen receptor-positive breast cancer. Ruth Oratz, Benjamin Kim, +4 authors, Michael Broder. less J Oncol Pract, 2011 Jul 07; 7(2). PMID: 21731516 Free PMC article.
Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. Françoise Rothé, Michail Ignatiadis, +9 authors, Christos Sotiriou. less PLoS One, 2011 Jul 09; 6(6). PMID: 21738599 Free PMC article. Highly Cited.
Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Kenneth L Scott, Cristina Nogueira, +19 authors, Lynda Chin. less Cancer Cell, 2011 Jul 12; 20(1). PMID: 21741599 Free PMC article.
Genomic biomarkers in predictive medicine: an interim analysis. Richard Simon. EMBO Mol Med, 2011 Jul 12; 3(8). PMID: 21744497 Free PMC article. Review.
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737. Samantha R Oakes, François Vaillant, +14 authors, Geoffrey J Lindeman. less Proc Natl Acad Sci U S A, 2011 Jul 20; 109(8). PMID: 21768359 Free PMC article.
Differentially expressed genes in window trials are influenced by the wound-healing process: lessons learned from a pilot study with anastrozole. Mary Morrogh, Victor P Andrade, +7 authors, Tari A King. less J Surg Res, 2011 Jul 23; 176(1). PMID: 21777924 Free PMC article.
Prognostic and Predictive Markers for Treatment Decisions in Early Breast Cancer. Elmar Stickeler. Breast Care (Basel), 2011 Jul 23; 6(3). PMID: 21779224 Free PMC article.
Identification of the YES1 Kinase as a Therapeutic Target in Basal-Like Breast Cancers. Erhan Bilal, Gabriela Alexe, +6 authors, Gyan Bhanot. less Genes Cancer, 2011 Jul 23; 1(10). PMID: 21779430 Free PMC article.
Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction. Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho. Breast Cancer Res, 2011 Jul 27; 13(3). PMID: 21787441 Free PMC article. Review.
Predictive and prognostic molecular markers for cancer medicine. Sunali Mehta, Andrew Shelling, +4 authors, Cristin Print. less Ther Adv Med Oncol, 2010 Mar 01; 2(2). PMID: 21789130 Free PMC article.
Innate immune cells in breast cancer--from villains to heroes? Tim Kees, Mikala Egeblad. J Mammary Gland Biol Neoplasia, 2011 Jul 27; 16(3). PMID: 21789554 Review.
Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response. Qiyuan Li, Aron C Eklund, +8 authors, Zoltan Szallasi. less BMC Bioinformatics, 2011 Jul 30; 12. PMID: 21798043 Free PMC article.
Challenges in the management of stage II colon cancer. Efrat Dotan, Steven J Cohen. Semin Oncol, 2011 Aug 04; 38(4). PMID: 21810510 Free PMC article. Review.
SEOM clinical guidelines for using molecular markers in clinical practice. Virginia Arrazubi, Roberto Pazo, Dolores Isla, José Luis Pérez Gracia. Clin Transl Oncol, 2011 Aug 09; 13(8). PMID: 21821495
Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence. Mary Jo Fackler, Christopher B Umbricht, +13 authors, Saraswati Sukumar. less Cancer Res, 2011 Aug 10; 71(19). PMID: 21825015 Free PMC article. Highly Cited.
A five-gene model predicts clinical outcome in ER+/PR+, early-stage breast cancers treated with adjuvant tamoxifen. Daniel Alan Kerr, James L Wittliff. Horm Cancer, 2011 Aug 10; 2(5). PMID: 21826535
A multivariate model of ErbB network composition predicts ovarian cancer cell response to canertinib. Rexxi D Prasasya, Kang Z Vang, Pamela K Kreeger. Biotechnol Bioeng, 2011 Aug 11; 109(1). PMID: 21830205 Free PMC article.
Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases. Anders Carlsson, Christer Wingren, +10 authors, Carl A K Borrebaeck. less Proc Natl Acad Sci U S A, 2011 Aug 17; 108(34). PMID: 21844363 Free PMC article.
Endogenous knockdown of survivin improves chemotherapeutic response in ALL models. D J Morrison, L E Hogan, +13 authors, W L Carroll. less Leukemia, 2011 Aug 17; 26(2). PMID: 21844871 Free PMC article.
Histopathological and genomic grading provide complementary prognostic information in breast cancer: a study on publicly available datasets. Nilotpal Chowdhury. Patholog Res Int, 2011 Aug 17; 2011. PMID: 21845210 Free PMC article.
Prognostic factors affecting postmastectomy locoregional recurrence in patients with early breast cancer: are intrinsic subtypes effective? Hakan Mersin, Kaptan Gülben, +4 authors, Sükrü Erdoğan. less World J Surg, 2011 Aug 20; 35(10). PMID: 21853356
Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling? Robin K Kelley, Alan P Venook. Clin Colorectal Cancer, 2011 Aug 24; 10(2). PMID: 21859557 Free PMC article. Review.
Challenges translating breast cancer gene signatures into the clinic. Britta Weigelt, Lajos Pusztai, Alan Ashworth, Jorge S Reis-Filho. Nat Rev Clin Oncol, 2011 Sep 01; 9(1). PMID: 21878891 Review.
Do all patients with breast cancer require systemic adjuvant therapy? Jennifer J Griggs, Daniel F Hayes. J Natl Cancer Inst, 2011 Sep 02; 103(18). PMID: 21881041 Free PMC article.
Genomic testing and therapies for breast cancer in clinical practice. Jennifer S Haas, Kathryn A Phillips, +5 authors, Michele Toscano. less J Oncol Pract, 2011 Sep 03; 7(3 Suppl). PMID: 21886507 Free PMC article.
US Insurance Program's Experience With a Multigene Assay for Early-Stage Breast Cancer. John Hornberger, Rebecca Chien, Katie Krebs, Louis Hochheiser. J Oncol Pract, 2011 Sep 03; 7(3 Suppl). PMID: 21886510 Free PMC article.
Impact of mammographic screening on the detection of good and poor prognosis breast cancers. Laura J Esserman, Yiwey Shieh, +8 authors, Laura J van 't Veer. less Breast Cancer Res Treat, 2011 Sep 06; 130(3). PMID: 21892702 Free PMC article. Review.
Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer. Ana M Gonzalez-Angulo, Bryan T Hennessy, +19 authors, Gordon B Mills. less Clin Proteomics, 2011 Sep 13; 8(1). PMID: 21906370 Free PMC article.
Clinical utility of serum tumor markers and circulating tumor cell assays in the treatment of breast cancer. Vandana G Abramson, Ingrid A Mayer. Curr Treat Options Oncol, 2011 Sep 16; 12(4). PMID: 21918859
Relationship between quantitative GRB7 RNA expression and recurrence after adjuvant anthracycline chemotherapy in triple-negative breast cancer. Joseph A Sparano, Lori J Goldstein, +13 authors, Robert Gray. less Clin Cancer Res, 2011 Sep 22; 17(22). PMID: 21933890 Free PMC article.
Breast medical oncologists' use of standard prognostic factors to predict a 21-gene recurrence score. Arif H Kamal, Charles L Loprinzi, +7 authors, Matthew P Goetz. less Oncologist, 2011 Sep 22; 16(10). PMID: 21934103 Free PMC article.
A new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis. Dong-Yu Wang, Susan J Done, +3 authors, Wey Liang Leong. less Breast Cancer Res, 2011 Sep 24; 13(5). PMID: 21939527 Free PMC article.
Estrogen receptor (ESR1) mRNA expression and benefit from tamoxifen in the treatment and prevention of estrogen receptor-positive breast cancer. Chungyeul Kim, Gong Tang, +18 authors, Soonmyung Paik. less J Clin Oncol, 2011 Sep 29; 29(31). PMID: 21947828 Free PMC article.
Recent progress and clinical importance on pharmacogenetics in cancer therapy. Thomas I Peng Soh, Wei Peng Yong, Federico Innocenti. Clin Chem Lab Med, 2011 Sep 29; 49(10). PMID: 21950596 Free PMC article. Review.
Improving communication of breast cancer recurrence risk. Noel T Brewer, Alice R Richman, +2 authors, Jessica T DeFrank, Valerie F Reyna, Lisa A Carey. less Breast Cancer Res Treat, 2011 Oct 04; 133(2). PMID: 21964579 Free PMC article.
Insight into the heterogeneity of breast cancer through next-generation sequencing. Hege G Russnes, Nicholas Navin, James Hicks, Anne-Lise Borresen-Dale. J Clin Invest, 2011 Oct 04; 121(10). PMID: 21965338 Free PMC article. Highly Cited. Review.
Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex. Laura Andrejka, Hong Wen, +5 authors, Joseph S Lipsick. less Proc Natl Acad Sci U S A, 2011 Oct 05; 108(42). PMID: 21969598 Free PMC article.
Ki 67 is a major, but not the sole determinant of Oncotype Dx recurrence score. S Sahebjam, R Aloyz, +6 authors, L C Panasci. less Br J Cancer, 2011 Oct 06; 105(9). PMID: 21970880 Free PMC article.
A clinically relevant gene signature in triple negative and basal-like breast cancer. Achim Rody, Thomas Karn, +11 authors, Manfred Kaufmann. less Breast Cancer Res, 2011 Oct 08; 13(5). PMID: 21978456 Free PMC article. Highly Cited.
Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer. Sang Cheul Oh, Yun-Yong Park, +11 authors, Ju-Seog Lee. less Gut, 2011 Oct 15; 61(9). PMID: 21997556 Free PMC article.
Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A Weinberg. Cell, 2011 Oct 18; 147(2). PMID: 22000009 Free PMC article. Highly Cited. Review.
Risk of recurrence and chemotherapy benefit for patients with node-negative, estrogen receptor-positive breast cancer: recurrence score alone and integrated with pathologic and clinical factors. Gong Tang, Jack Cuzick, +6 authors, Norman Wolmark. less J Clin Oncol, 2011 Oct 20; 29(33). PMID: 22010013 Free PMC article.
The effect of Oncotype DX recurrence score on treatment recommendations for patients with estrogen receptor-positive early stage breast cancer and correlation with estimation of recurrence risk by breast cancer specialists. Jennifer E Joh, Nicole N Esposito, +10 authors, Geza Acs. less Oncologist, 2011 Oct 22; 16(11). PMID: 22016474 Free PMC article.
Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Yoko S DeRose, Guoying Wang, +12 authors, Alana L Welm. less Nat Med, 2011 Oct 25; 17(11). PMID: 22019887 Free PMC article. Highly Cited.
Integrating contextual miRNA and protein signatures for diagnostic and treatment decisions in cancer. Lorenzo F Sempere. Expert Rev Mol Diagn, 2011 Oct 26; 11(8). PMID: 22022944 Free PMC article. Review.
Most random gene expression signatures are significantly associated with breast cancer outcome. David Venet, Jacques E Dumont, Vincent Detours. PLoS Comput Biol, 2011 Oct 27; 7(10). PMID: 22028643 Free PMC article. Highly Cited.
Clinical trials in the era of personalized oncology. Michael L Maitland, Richard L Schilsky. CA Cancer J Clin, 2011 Oct 29; 61(6). PMID: 22034206 Free PMC article.
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Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. Ubaldo E Martinez-Outschoorn, Allison Goldberg, +8 authors, Michael P Lisanti. less Cancer biology & therapy, 2011 Nov 02; 12(10). PMID: 22041887 Free PMC article.
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Translating mathematical modeling of tumor growth patterns into novel therapeutic approaches for breast cancer. Elizabeth Comen, Patrick G Morris, Larry Norton. J Mammary Gland Biol Neoplasia, 2012 Sep 27; 17(3-4). PMID: 23011603 Review.
Study designs and statistical analyses for biomarker research. Masahiko Gosho, Kengo Nagashima, Yasunori Sato. Sensors (Basel), 2012 Sep 27; 12(7). PMID: 23012528 Free PMC article. Review.
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Immunoglobulin kappa C predicts overall survival in node-negative breast cancer. Zonglin Chen, Aslihan Gerhold-Ay, +13 authors, Marcus Schmidt. less PLoS One, 2012 Oct 03; 7(9). PMID: 23028600 Free PMC article.
Identification of common prognostic gene expression signatures with biological meanings from microarray gene expression datasets. Jun Yao, Qi Zhao, +4 authors, John N Weinstein. less PLoS One, 2012 Oct 03; 7(9). PMID: 23029298 Free PMC article.
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EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer. P Dubsky, M Filipits, +17 authors, Austrian Breast and Colorectal Cancer Study Group (ABCSG). less Ann Oncol, 2012 Oct 05; 24(3). PMID: 23035151 Free PMC article.
PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers. Roy R L Bastien, Álvaro Rodríguez-Lescure, +29 authors, Miguel Martín. less BMC Med Genomics, 2012 Oct 06; 5. PMID: 23035882 Free PMC article. Highly Cited.
Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test. Ralf Kronenwett, Kerstin Bohmann, +16 authors, Carsten Denkert. less BMC Cancer, 2012 Oct 09; 12. PMID: 23039280 Free PMC article.
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nathan E Reticker-Flynn, David F Braga Malta, +6 authors, Sangeeta N Bhatia. less Nat Commun, 2012 Oct 11; 3. PMID: 23047680 Free PMC article. Highly Cited.
Molecular alterations associated with breast cancer mortality. Laura M Voeghtly, Kim Mamula, +2 authors, J Leigh Campbell, Craig D Shriver, Rachel E Ellsworth. less PLoS One, 2012 Oct 12; 7(10). PMID: 23056464 Free PMC article.
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Gene expression profiling for guiding adjuvant chemotherapy decisions in women with early breast cancer: an evidence-based and economic analysis. Medical Advisory Secretariat. Ont Health Technol Assess Ser, 2010 Jan 01; 10(23). PMID: 23074401 Free PMC article.
Are we ready to stratify treatment for diffuse large B-cell lymphoma using molecular hallmarks? Sarah Barton, Eliza A Hawkes, Andrew Wotherspoon, David Cunningham. Oncologist, 2012 Oct 23; 17(12). PMID: 23086691 Free PMC article. Review.
Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer. Funda Meric-Bernstam, Huiqin Chen, +6 authors, Ana Gonzalez-Angulo. less Breast Cancer Res, 2012 Oct 30; 14(5). PMID: 23102376 Free PMC article.
A molecular assay of tumor radiosensitivity: a roadmap towards biology-based personalized radiation therapy. Javier F Torres-Roca. Per Med, 2012 Oct 30; 9(5). PMID: 23105945 Free PMC article.
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The 21-gene recurrence score assay impacts adjuvant therapy recommendations for ER-positive, node-negative and node-positive early breast cancer resulting in a risk-adapted change in chemotherapy use. W Eiermann, M Rezai, +13 authors, J Blohmer. less Ann Oncol, 2012 Nov 09; 24(3). PMID: 23136233 Free PMC article.
Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer. Siwei Wei, Lingyan Liu, +8 authors, Daniel Raftery. less Mol Oncol, 2012 Nov 13; 7(3). PMID: 23142658 Free PMC article.
The prognostic and predictive value of mRNA expression of vascular endothelial growth factor family members in breast cancer: a study in primary tumors of high-risk early breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial. Helena Linardou, Konstantine T Kalogeras, +10 authors, George Fountzilas. less Breast Cancer Res, 2012 Nov 14; 14(6). PMID: 23146280 Free PMC article.
Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors. Marcus Schmidt, Patrick Micke, Mathias Gehrmann, Jan G Hengstler. Oncoimmunology, 2012 Nov 22; 1(7). PMID: 23170262 Free PMC article.
Accelerated partial breast irradiation for early-stage breast cancer: controversies and current indications for use. Lisa C Klepczyk, Kimberly S Keene, Jennifer F De Los Santos. Curr Treat Options Oncol, 2012 Nov 28; 14(1). PMID: 23179757 Review.
Barriers to the use of personalized medicine in breast cancer. Christine B Weldon, Julia R Trosman, +2 authors, William J Gradishar, Al B Benson, Julian C Schink. less J Oncol Pract, 2012 Nov 28; 8(4). PMID: 23180995 Free PMC article.
New perspectives for in vitro risk assessment of multiwalled carbon nanotubes: application of coculture and bioinformatics. Brandi N Snyder-Talkington, Yong Qian, Vincent Castranova, Nancy L Guo. J Toxicol Environ Health B Crit Rev, 2012 Nov 30; 15(7). PMID: 23190270 Free PMC article.
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Prediction and prognosis: impact of gene expression profiling in personalized treatment of breast cancer patients. Michael R Mallmann, Andrea Staratschek-Jox, +5 authors, Joachim L Schultze. less EPMA J, 2010 Sep 01; 1(3). PMID: 23199086 Free PMC article.
Challenges and solutions in the development of genomic biomarker panels: a systematic phased approach. K Shahzad, A Fatima, +5 authors, Mc Deng. less Curr Genomics, 2012 Dec 04; 13(4). PMID: 23204923 Free PMC article.
Phosphorylation of p90RSK is associated with increased response to neoadjuvant chemotherapy in ER-positive breast cancer. Hyeong-Gon Moon, Jae Kyo Yi, +9 authors, Dong-Young Noh. less BMC Cancer, 2012 Dec 12; 12. PMID: 23216670 Free PMC article.
Molecular profiles of pre- and postoperative breast cancer tumours reveal differentially expressed genes. Margit L H Riis, Torben Lüders, +4 authors, Ida R K Bukholm. less ISRN Oncol, 2012 Dec 12; 2012. PMID: 23227362 Free PMC article.
Treatment when prognostic factors do not match St. Gallen recommendations: profiling of prognostic factors among HR(+) and HER2(-) breast cancer patients. Kyoko Satoh, Maki Tanaka, +2 authors, Ayako Yano, Jiang Ying, Tatsuyuki Kakuma. less World J Surg, 2012 Dec 12; 37(3). PMID: 23229849
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Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin). Begoña Martin-Castillo, Cristina Oliveras-Ferraros, +7 authors, Javier A Menendez. less Cell cycle (Georgetown, Tex.), 2012 Dec 21; 12(2). PMID: 23255137 Free PMC article.
Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. Roel G W Verhaak, Pablo Tamayo, +39 authors, Cancer Genome Atlas Research Network. less J Clin Invest, 2012 Dec 22; 123(1). PMID: 23257362 Free PMC article. Highly Cited.
Sample parameters affecting the clinical relevance of RNA biomarkers in translational breast cancer research. Vassiliki Kotoula, Konstantine T Kalogeras, +4 authors, George Fountzilas. less Virchows Arch, 2012 Dec 25; 462(2). PMID: 23262785 Free PMC article.
Rational design of the survivin/CDK4 complex by combining protein-protein docking and molecular dynamics simulations. Jana Selent, Agnieszka A Kaczor, +3 authors, Cristian Obiol-Pardo. less J Mol Model, 2012 Dec 25; 19(4). PMID: 23263360
Omics Screening for Pharmaceutical Efficacy and Safety in Clinical Practice. Andrew A Monte, Vasilis Vasiliou, Kennon J Heard. J Pharmacogenomics Pharmacoproteomics, 2012 Dec 25; S5. PMID: 23264882 Free PMC article.
14-3-3ζ as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers. Anna Bergamaschi, Jonna Frasor, +5 authors, Benita S Katzenellenbogen. less Breast Cancer Res Treat, 2012 Dec 29; 137(3). PMID: 23271328 Free PMC article.
Oncoshare: lessons learned from building an integrated multi-institutional database for comparative effectiveness research. Susan C Weber, Tina Seto, +3 authors, Amar K Das. less AMIA Annu Symp Proc, 2013 Jan 11; 2012. PMID: 23304372 Free PMC article.
Towards mechanism classifiers: expression-anchored Gene Ontology signature predicts clinical outcome in lung adenocarcinoma patients. Xinan Yang, Haiquan Li, +3 authors, Kelly Regan, Jianrong Li, Yong Huang, Yves A Lussier. less AMIA Annu Symp Proc, 2013 Jan 11; 2012. PMID: 23304380 Free PMC article.
Selecting cases for whom additional tests can improve prognostication. Xiaoqian Jiang, Jihoon Kim, +2 authors, Yuan Wu, Shuang Wang, Lucila Ohno-Machado. less AMIA Annu Symp Proc, 2013 Jan 11; 2012. PMID: 23304404 Free PMC article.
The genomic landscape of breast cancer as a therapeutic roadmap. Matthew J Ellis, Charles M Perou. Cancer Discov, 2013 Jan 16; 3(1). PMID: 23319768 Free PMC article. Highly Cited.
A 13-gene signature prognostic of HPV-negative OSCC: discovery and external validation. Pawadee Lohavanichbutr, Eduardo Méndez, +8 authors, Chu Chen. less Clin Cancer Res, 2013 Jan 16; 19(5). PMID: 23319825 Free PMC article.
Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. Jing Chen, Cynthia A Pise-Masison, +5 authors, Thomas A Waldmann. less Blood, 2013 Jan 17; 121(11). PMID: 23321252 Free PMC article.
Gene signatures in breast cancer: current and future uses. Enrique Espinosa Arranz, Juan Ángel Fresno Vara, Angelo Gámez-Pozo, Pilar Zamora. Transl Oncol, 2013 Jan 17; 5(6). PMID: 23323153 Free PMC article.
Engaging in health behaviors to lower risk for breast cancer recurrence. Suzanne C O'Neill, Jessica T DeFrank, +4 authors, Noel T Brewer. less PLoS One, 2013 Jan 18; 8(1). PMID: 23326466 Free PMC article.
A genomic approach to active surveillance: a step toward precision medicine. Eric A Klein. Asian J Androl, 2013 Jan 22; 15(3). PMID: 23334203 Free PMC article.
Challenges in Biomarker Discovery: Combining Expert Insights with Statistical Analysis of Complex Omics Data. Jason E McDermott, Jing Wang, +4 authors, Karin D Rodland. less Expert Opin Med Diagn, 2013 Jan 22; 7(1). PMID: 23335946 Free PMC article.
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Patient-derived breast tumor xenografts facilitating personalized cancer therapy. Melissa D Landis, Brian D Lehmann, Jennifer A Pietenpol, Jenny C Chang. Breast Cancer Res, 2013 Jan 24; 15(1). PMID: 23339383 Free PMC article. Review.
Citizens' perspectives on personalized medicine: a qualitative public deliberation study. Yvonne Bombard, Julia Abelson, Dorina Simeonov, Francois-Pierre Gauvin. Eur J Hum Genet, 2013 Jan 24; 21(11). PMID: 23340511 Free PMC article.
Germline DNA copy number aberrations identified as potential prognostic factors for breast cancer recurrence. Yadav Sapkota, Sunita Ghosh, +5 authors, Sambasivarao Damaraju. less PLoS One, 2013 Jan 24; 8(1). PMID: 23342018 Free PMC article.
Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study. Maria B Lyng, Anne-Vibeke Lænkholm, +4 authors, Henrik J Ditzel. less PLoS One, 2013 Jan 24; 8(1). PMID: 23342080 Free PMC article.
Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer. Shulamit Sebban, Marganit Farago, +4 authors, Shulamit Katzav. less PLoS One, 2013 Jan 24; 8(1). PMID: 23342133 Free PMC article.
Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. D Gonzalez de Castro, P A Clarke, B Al-Lazikani, P Workman. Clin Pharmacol Ther, 2013 Jan 31; 93(3). PMID: 23361103 Free PMC article. Highly Cited. Review.
Translating metastasis-related biomarkers to the clinic--progress and pitfalls. François-Clément Bidard, Jean-Yves Pierga, Jean-Charles Soria, Jean Paul Thiery. Nat Rev Clin Oncol, 2013 Feb 06; 10(3). PMID: 23381003 Review.
A data similarity-based strategy for meta-analysis of transcriptional profiles in cancer. Qingchao Qiu, Pengcheng Lu, +6 authors, Yajun Yi. less PLoS One, 2013 Feb 06; 8(1). PMID: 23383020 Free PMC article.
A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer. Takayuki Kobayashi, Keiichi Iwaya, +4 authors, Osamu Matsubara. less BMC Clin Pathol, 2013 Feb 07; 13. PMID: 23384409 Free PMC article.
Guanylyl cyclase C as a biomarker in colorectal cancer. Terry Hyslop, Scott A Waldman. Biomark Med, 2013 Feb 08; 7(1). PMID: 23387497 Free PMC article. Review.
A new genome-driven integrated classification of breast cancer and its implications. Sarah-Jane Dawson, Oscar M Rueda, Samuel Aparicio, Carlos Caldas. EMBO J, 2013 Feb 12; 32(5). PMID: 23395906 Free PMC article. Highly Cited. Review.
Where medicine, business, and public policy intersect. Chantell L Wilson, Stephanie Schultz, Scott A Waldman. Biotechnol Healthc, 2007 Feb 01; 4(1). PMID: 23397413 Free PMC article.
Biclustering reveals breast cancer tumour subgroups with common clinical features and improves prediction of disease recurrence. Yi Kan Wang, Cristin G Print, Edmund J Crampin. BMC Genomics, 2013 Feb 15; 14. PMID: 23405961 Free PMC article.
Essential nontranslational functions of tRNA synthetases. Min Guo, Paul Schimmel. Nat Chem Biol, 2013 Feb 19; 9(3). PMID: 23416400 Free PMC article. Highly Cited. Review.
Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon? Olga Golubnitschaja, Kristina Yeghiazaryan, +5 authors, Hans H Schild. less EPMA J, 2013 Feb 20; 4(1). PMID: 23418957 Free PMC article.
PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer. Miguel Martín, Aleix Prat, +24 authors, Philip S Bernard. less Breast Cancer Res Treat, 2013 Feb 21; 138(2). PMID: 23423445 Free PMC article.
Interpreting personal transcriptomes: personalized mechanism-scale profiling of RNA-seq data. Alan Perez-Rathke, Haiquan Li, Yves A Lussier. Pac Symp Biocomput, 2013 Feb 21;. PMID: 23424121 Free PMC article.
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. C L Avery, C M Sitlani, +51 authors, B M Psaty. less Pharmacogenomics J, 2013 Mar 06; 14(1). PMID: 23459443 Free PMC article.
Molecular staging of node negative patients with colorectal cancer. Terry Hyslop, Scott A Waldman. J Cancer, 2013 Mar 06; 4(3). PMID: 23459453 Free PMC article.
Cultivating cohort studies for observational translational research. David F Ransohoff. Cancer Epidemiol Biomarkers Prev, 2013 Mar 07; 22(4). PMID: 23462919 Free PMC article.
Biomolecular events in cancer revealed by attractor metagenes. Wei-Yi Cheng, Tai-Hsien Ou Yang, Dimitris Anastassiou. PLoS Comput Biol, 2013 Mar 08; 9(2). PMID: 23468608 Free PMC article.
The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer. Attila Marcell Szász, Qiyuan Li, +10 authors, Janina Kulka. less PLoS One, 2013 Mar 08; 8(2). PMID: 23468873 Free PMC article.
Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Djuana M E Harvell, Jihye Kim, +5 authors, Kathryn B Horwitz. less Horm Cancer, 2013 Mar 13; 4(3). PMID: 23479404 Free PMC article.
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Stina Mui Singel, Crystal Cornelius, +4 authors, Jerry W Shay. less Clin Cancer Res, 2013 Mar 13; 19(8). PMID: 23479679 Free PMC article.
Overexpression of MACC1 and Its significance in human Breast Cancer Progression. Yongbo Huang, Huizhong Zhang, +5 authors, Mengfeng Li. less Cell Biosci, 2013 Mar 19; 3(1). PMID: 23497677 Free PMC article.
Prediction of the Oncotype DX recurrence score: use of pathology-generated equations derived by linear regression analysis. Molly E Klein, David J Dabbs, +4 authors, Rohit Bhargava. less Mod Pathol, 2013 Mar 19; 26(5). PMID: 23503643 Free PMC article.
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Comparison of EndoPredict and Oncotype DX test results in hormone receptor positive invasive breast cancer. Zsuzsanna Varga, Peter Sinn, +6 authors, Holger Moch. less PLoS One, 2013 Mar 19; 8(3). PMID: 23505515 Free PMC article.
Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model. Christian Franci, Jenny Zhou, +4 authors, Hosein Kouros-Mehr. less PLoS One, 2013 Mar 23; 8(3). PMID: 23520493 Free PMC article.
Long-term prognostic performance of Ki67 rate in early stage, pT1-pT2, pN0, invasive breast carcinoma. Fabien Reyal, David Hajage, +14 authors, Xavier Sastre-Garau. less PLoS One, 2013 Mar 26; 8(3). PMID: 23526930 Free PMC article.
Biologic determinants of tumor recurrence in stage II colon cancer: validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581. Alan P Venook, Donna Niedzwiecki, +12 authors, Monica M Bertagnolli. less J Clin Oncol, 2013 Mar 27; 31(14). PMID: 23530100 Free PMC article.
Development and validation of a 32-gene prognostic index for prostate cancer progression. Chin-Lee Wu, Brock E Schroeder, +8 authors, W Scott McDougal. less Proc Natl Acad Sci U S A, 2013 Mar 28; 110(15). PMID: 23533275 Free PMC article.
Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways. Margit L H Riis, Xi Zhao, +6 authors, Vessela N Kristensen. less ISRN Oncol, 2013 Mar 28; 2013. PMID: 23533813 Free PMC article.
Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker. Saleh M Rachidi, Tingting Qin, +2 authors, Shaoli Sun, W Jim Zheng, Zihai Li. less PLoS One, 2013 Mar 29; 8(3). PMID: 23536776 Free PMC article.
Monitoring apoptosis and Bcl-2 on circulating tumor cells in patients with metastatic breast cancer. Jeffrey B Smerage, G Thomas Budd, +9 authors, Daniel F Hayes. less Mol Oncol, 2013 Mar 30; 7(3). PMID: 23538216 Free PMC article.
Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer. Patrick C O Leary, Sarah A Penny, +12 authors, William M Gallagher. less BMC Cancer, 2013 Apr 04; 13. PMID: 23547718 Free PMC article.
The combination of Ki67, histological grade and estrogen receptor status identifies a low-risk group among 1,854 chemo-naïve women with N0/N1 primary breast cancer. Carina Strand, Martin Bak, +13 authors, Mårten Fernö. less Springerplus, 2013 Apr 06; 2(1). PMID: 23560250 Free PMC article.
Development of a miR-26 companion diagnostic test for adjuvant interferon-alpha therapy in hepatocellular carcinoma. Junfang Ji, Lei Yu, +12 authors, Xin Wei Wang. less Int J Biol Sci, 2013 Apr 10; 9(3). PMID: 23569435 Free PMC article.
Gene expression profiling in breast cancer. Belisario A Arango, Celine L Rivera, Stefan Glück. Am J Transl Res, 2013 Apr 11; 5(2). PMID: 23573359 Free PMC article.
Molecular and therapeutic advances in the diagnosis and management of malignant pheochromocytomas and paragangliomas. Aoife J Lowery, Siun Walsh, Enda W McDermott, Ruth S Prichard. Oncologist, 2013 Apr 12; 18(4). PMID: 23576482 Free PMC article. Review.
Development of a multi-biomarker disease activity test for rheumatoid arthritis. Michael Centola, Guy Cavet, +14 authors, Jeffrey R Curtis. less PLoS One, 2013 Apr 16; 8(4). PMID: 23585841 Free PMC article.
Building a personalized medicine infrastructure at a major cancer center. Funda Meric-Bernstam, Carol Farhangfar, John Mendelsohn, Gordon B Mills. J Clin Oncol, 2013 Apr 17; 31(15). PMID: 23589548 Free PMC article. Review.
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer. Stefano Volinia, Carlo M Croce. Proc Natl Acad Sci U S A, 2013 Apr 17; 110(18). PMID: 23589849 Free PMC article. Highly Cited.
Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules. De Pradip, Mark Bouzyk, Nandini Dey, Brian Leyland-Jones. Am J Cancer Res, 2013 Apr 18; 3(2). PMID: 23593540 Free PMC article.
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer. Adam A Margolin, Erhan Bilal, +27 authors, Anne-Lise Børresen-Dale. less Sci Transl Med, 2013 Apr 19; 5(181). PMID: 23596205 Free PMC article.
Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer. Zhongpeng Zhu, Baocheng Wang, +6 authors, Jun Wang. less Tumour Biol, 2013 Apr 23; 34(4). PMID: 23605320
Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis. Srikanth Nagalla, Jeff W Chou, +9 authors, Lance D Miller. less Genome Biol, 2013 Apr 27; 14(4). PMID: 23618380 Free PMC article. Highly Cited.
A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer. Satoko Yamamoto, Mutsuko Yamamoto-Ibusuki, +2 authors, Yutaka Yamamoto, Saori Fujiwara, Hirotaka Iwase. less BMC Cancer, 2013 May 01; 13. PMID: 23627634 Free PMC article.
Interpreting cancer biology: refining our therapeutic algorithm in breast cancer. Gabriel Hortobágyi, Pierfranco Conte. Oncologist, 2013 May 02; 18(4). PMID: 23633451 Free PMC article.
A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast. Lawrence J Solin, Robert Gray, +13 authors, Sunil Badve. less J Natl Cancer Inst, 2013 May 04; 105(10). PMID: 23641039 Free PMC article. Highly Cited.
Identification and validation of a new set of five genes for prediction of risk in early breast cancer. Giorgio Mustacchi, Maria Pia Sormani, +5 authors, Luca Morandi. less Int J Mol Sci, 2013 May 08; 14(5). PMID: 23648477 Free PMC article.
Multiple suboptimal solutions for prediction rules in gene expression data. Osamu Komori, Mari Pritchard, Shinto Eguchi. Comput Math Methods Med, 2013 May 11; 2013. PMID: 23662163 Free PMC article.
Improving breast cancer survival analysis through competition-based multidimensional modeling. Erhan Bilal, Janusz Dutkowski, +21 authors, Adam A Margolin. less PLoS Comput Biol, 2013 May 15; 9(5). PMID: 23671412 Free PMC article.
Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry. E C Inwald, M Klinkhammer-Schalke, +4 authors, O Ortmann. less Breast Cancer Res Treat, 2013 May 16; 139(2). PMID: 23674192 Free PMC article. Highly Cited.
A simple and reproducible breast cancer prognostic test. Luigi Marchionni, Bahman Afsari, Donald Geman, Jeffrey T Leek. BMC Genomics, 2013 May 21; 14. PMID: 23682826 Free PMC article.
Genomic biomarkers for personalized medicine: development and validation in clinical studies. Shigeyuki Matsui. Comput Math Methods Med, 2013 May 22; 2013. PMID: 23690882 Free PMC article. Review.
Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer. Vered Stearns, Lisa K Jacobs, +16 authors, Nancy E Davidson. less Clin Cancer Res, 2013 May 31; 19(14). PMID: 23719261 Free PMC article.
Multigene assays and molecular markers in breast cancer: systematic review of health economic analyses. Roman Rouzier, Paolo Pronzato, +3 authors, William J Valentine. less Breast Cancer Res Treat, 2013 Jun 01; 139(3). PMID: 23722312 Free PMC article. Systematic Review.
Fertility preservation in young females with non-gynaecologic malignancy: an emerging speciality. C Smyth, I Robertson, +5 authors, K Barry. less Ir J Med Sci, 2013 Jun 07; 183(1). PMID: 23740204
Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response. Rinath M Jeselsohn, Lillian Werner, +11 authors, Steven E Come. less PLoS One, 2013 Jun 07; 8(5). PMID: 23741308 Free PMC article.
A panel of four cytokines predicts the prognosis of patients with malignant gliomas. Yi Lin, Guozhen Zhang, +9 authors, Tao Jiang. less J Neurooncol, 2013 Jun 12; 114(2). PMID: 23748572
Integrative analysis of cancer-related signaling pathways. Thomas Kessler, Hendrik Hache, Christoph Wierling. Front Physiol, 2013 Jun 14; 4. PMID: 23760067 Free PMC article.
Association between genomic recurrence risk and well-being among breast cancer patients. Valesca P Retèl, Catharina G M Groothuis-Oudshoorn, +3 authors, Wim H van Harten. less BMC Cancer, 2013 Jun 20; 13. PMID: 23777535 Free PMC article.
The impact of the 21-gene Recurrence Score assay on clinical decision-making in node-positive (up to 3 positive nodes) estrogen receptor-positive breast cancer patients. Salomon M Stemmer, Shmuel H Klang, +7 authors, Nicky Lieberman. less Breast Cancer Res Treat, 2013 Jun 27; 140(1). PMID: 23801158 Free PMC article.
A multi-site feasibility study for personalized medicine in canines with osteosarcoma. Noel R Monks, David M Cherba, +10 authors, Craig P Webb. less J Transl Med, 2013 Jul 03; 11. PMID: 23815880 Free PMC article.
Interrogating differences in expression of targeted gene sets to predict breast cancer outcome. Sarah A Andres, Guy N Brock, James L Wittliff. BMC Cancer, 2013 Jul 04; 13. PMID: 23819905 Free PMC article.
Curation-free biomodules mechanisms in prostate cancer predict recurrent disease. James L Chen, Alexander Hsu, +5 authors, Yves A Lussier. less BMC Med Genomics, 2013 Jul 17; 6 Suppl 2. PMID: 23819917 Free PMC article.
BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome. Stephen F Madden, Colin Clarke, +5 authors, William M Gallagher. less Breast Cancer Res, 2013 Jul 04; 15(4). PMID: 23820017 Free PMC article. Highly Cited.
Evaluation of a high-throughput, microfluidics platform for performing TaqMan™ qPCR using formalin-fixed paraffin-embedded tumors. Ping Li, Elena Grigorenko, +3 authors, Hyung L Kim. less Bioanalysis, 2013 Jul 05; 5(13). PMID: 23822126 Free PMC article.
Serine, glycine and one-carbon units: cancer metabolism in full circle. Jason W Locasale. Nat Rev Cancer, 2013 Jul 05; 13(8). PMID: 23822983 Free PMC article. Highly Cited. Review.
The EndoPredict Gene-Expression Assay in Clinical Practice - Performance and Impact on Clinical Decisions. Berit Maria Müller, Elke Keil, +16 authors, Carsten Denkert. less PLoS One, 2013 Jul 05; 8(6). PMID: 23826382 Free PMC article.
Metasignatures identify two major subtypes of breast cancer. Q Duan, Y Kou, +2 authors, N R Clark, S Gordonov, A Ma'ayan. less CPT Pharmacometrics Syst Pharmacol, 2013 Jul 10; 2. PMID: 23836026 Free PMC article.
Liquid biopsy: monitoring cancer-genetics in the blood. Emily Crowley, Federica Di Nicolantonio, Fotios Loupakis, Alberto Bardelli. Nat Rev Clin Oncol, 2013 Jul 10; 10(8). PMID: 23836314 Highly Cited. Review.
The DREAM complex: master coordinator of cell cycle-dependent gene expression. Subhashini Sadasivam, James A DeCaprio. Nat Rev Cancer, 2013 Jul 12; 13(8). PMID: 23842645 Free PMC article. Highly Cited. Review.
An integrative framework for Bayesian variable selection with informative priors for identifying genes and pathways. Bin Peng, Dianwen Zhu, +4 authors, Xiaowei Yang. less PLoS One, 2013 Jul 12; 8(7). PMID: 23844055 Free PMC article.
Using large-scale molecular data sets to improve breast cancer treatment. Chad J Creighton. Breast Cancer Manag, 2012 May 01; 1(1). PMID: 23869198 Free PMC article.
Genes dysregulated to different extent or oppositely in estrogen receptor-positive and estrogen receptor-negative breast cancers. Xianxiao Zhou, Tongwei Shi, +6 authors, Zheng Guo. less PLoS One, 2013 Jul 23; 8(7). PMID: 23875016 Free PMC article.
High-throughput identification of reference genes for research and clinical RT-qPCR analysis of breast cancer samples. Diana V Maltseva, Nadezda A Khaustova, +6 authors, Alexander G Tonevitsky. less J Clin Bioinforma, 2013 Jul 24; 3(1). PMID: 23876162 Free PMC article.
MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy. Stefan Heinrichs, Lillian F Conover, +9 authors, A Thomas Look. less Elife, 2013 Jul 24; 2. PMID: 23878725 Free PMC article.
Cellular iron metabolism in prognosis and therapy of breast cancer. Suzy V Torti, Frank M Torti. Crit Rev Oncog, 2013 Jul 25; 18(5). PMID: 23879588 Free PMC article. Review.
Luminal breast cancer: from biology to treatment. Michail Ignatiadis, Christos Sotiriou. Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035 Review.
Breast cancer metastasis: issues for the personalization of its prevention and treatment. Natascia Marino, Stephan Woditschka, +4 authors, Patricia S Steeg. less Am J Pathol, 2013 Jul 31; 183(4). PMID: 23895915 Free PMC article. Review.
Who gets genomic testing for breast cancer recurrence risk? J T DeFrank, T Salz, K Reeder-Hayes, N T Brewer. Public Health Genomics, 2013 Aug 01; 16(5). PMID: 23899493 Free PMC article.
The genomic map of breast cancer: which roads lead to better targeted therapies? Justin M Balko, Thomas P Stricker, Carlos L Arteaga. Breast Cancer Res, 2013 Aug 03; 15(4). PMID: 23905624 Free PMC article. Review.
A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences. Lorenza Mittempergher, Mahasti Saghatchian, +9 authors, Laura J van't Veer. less Mol Oncol, 2013 Aug 06; 7(5). PMID: 23910573 Free PMC article.
Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics. Floris H Groenendijk, Wilbert Zwart, +2 authors, Arno Floore, Stephanie Akbari, Rene Bernards. less Breast Cancer Res Treat, 2013 Aug 06; 140(3). PMID: 23912957 Free PMC article.
[Gene expression analysis in breast cancer. A new diagnostic tool in pathology]. C Denkert. Pathologe, 2013 Aug 13; 34(5). PMID: 23934410 Review.
Evaluating use characteristics for the oncotype dx 21-gene recurrence score and concordance with chemotherapy use in early-stage breast cancer. Clara Chen, Rahul Dhanda, +2 authors, Wan-Yu Tseng, Michael Forsyth, Debra A Patt. less J Oncol Pract, 2013 Aug 15; 9(4). PMID: 23942918 Free PMC article.
A Tumor initiating cell-enriched prognostic signature for HER2+:ERα- breast cancer; rationale, new features, controversies and future directions. Jeff C Liu, Sean E Egan, Eldad Zacksenhaus. Oncotarget, 2013 Aug 16; 4(8). PMID: 23945331 Free PMC article.
Identification and validation of a multigene predictor of recurrence in primary laryngeal cancer. Elena Fountzilas, Vassiliki Kotoula, +8 authors, George Fountzilas. less PLoS One, 2013 Aug 21; 8(8). PMID: 23950933 Free PMC article.
Preoperative core needle biopsy is accurate in determining molecular subtypes in invasive breast cancer. Xiaosong Chen, Long Sun, +10 authors, Kunwei Shen. less BMC Cancer, 2013 Aug 21; 13. PMID: 23957561 Free PMC article.
The impact of the Oncotype Dx breast cancer assay in clinical practice: a systematic review and meta-analysis. Josh J Carlson, Joshua A Roth. Breast Cancer Res Treat, 2013 Aug 27; 141(1). PMID: 23974828 Free PMC article. Highly Cited. Systematic Review.
Grading breast cancer tissues using molecular portraits. Niclas Olsson, Petter Carlsson, +7 authors, Carl A K Borrebaeck. less Mol Cell Proteomics, 2013 Aug 29; 12(12). PMID: 23982162 Free PMC article.
Genomic Grade Index (GGI): feasibility in routine practice and impact on treatment decisions in early breast cancer. Otto Metzger-Filho, Aurélie Catteau, +21 authors, Christos Sotiriou. less PLoS One, 2013 Aug 31; 8(8). PMID: 23990869 Free PMC article.
Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine. Ashley G Rivenbark, Siobhan M O'Connor, William B Coleman. Am J Pathol, 2013 Sep 03; 183(4). PMID: 23993780 Free PMC article. Review.
Development of omics-based clinical tests for prognosis and therapy selection: the challenge of achieving statistical robustness and clinical utility. Lisa M McShane, Mei-Yin C Polley. Clin Trials, 2013 Sep 04; 10(5). PMID: 24000377 Free PMC article.
Identification of upstream regulators for prognostic expression signature genes in colorectal cancer. Taejeong Bae, Kyoohyoung Rho, +3 authors, Sunghoon Kim. less BMC Syst Biol, 2013 Sep 07; 7. PMID: 24006872 Free PMC article.
Effect of chemotherapy for luminal a breast cancer. Naotaka Uchida, Takako Suda, Kiyosuke Ishiguro. Yonago Acta Med, 2013 Sep 14; 56(2). PMID: 24031152 Free PMC article.
Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population. Dennis C Sgroi, Ivana Sestak, +9 authors, Mitch Dowsett. less Lancet Oncol, 2013 Sep 17; 14(11). PMID: 24035531 Free PMC article. Highly Cited.
Integration of cancer genomics with treatment selection: from the genome to predictive biomarkers. Thomas J Ow, Vlad C Sandulache, Heath D Skinner, Jeffrey N Myers. Cancer, 2013 Sep 17; 119(22). PMID: 24037788 Free PMC article. Review.
Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules. Jing Chen, Zhen Hu, +4 authors, Mario Medvedovic. less PLoS Comput Biol, 2013 Sep 17; 9(9). PMID: 24039560 Free PMC article.
Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization. Ji-Young Jang, Jong-Kuen Lee, Yoon-Kyung Jeon, Chul-Woo Kim. BMC Cancer, 2013 Sep 21; 13. PMID: 24044575 Free PMC article.
Validation of a proliferation-based expression signature as prognostic marker in early stage lung adenocarcinoma. Ignacio I Wistuba, Carmen Behrens, +16 authors, Edward S Kim. less Clin Cancer Res, 2013 Sep 21; 19(22). PMID: 24048333 Free PMC article.
Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers. Giampaolo Bianchini, Lajos Pusztai, +16 authors, Luca Gianni. less Breast Cancer Res, 2013 Sep 26; 15(5). PMID: 24060333 Free PMC article.
SurvExpress: an online biomarker validation tool and database for cancer gene expression data using survival analysis. Raul Aguirre-Gamboa, Hugo Gomez-Rueda, +5 authors, Victor Treviño. less PLoS One, 2013 Sep 26; 8(9). PMID: 24066126 Free PMC article. Highly Cited.
The molecular diversity of Luminal A breast tumors. Giovanni Ciriello, Rileen Sinha, +5 authors, Nikolaus Schultz. less Breast Cancer Res Treat, 2013 Oct 08; 141(3). PMID: 24096568 Free PMC article.
18F-FDG uptake in breast cancer correlates with immunohistochemically defined subtypes. Hye Ryoung Koo, Jeong Seon Park, +9 authors, Woo Kyung Moon. less Eur Radiol, 2013 Oct 08; 24(3). PMID: 24097303
Concurrent gene signatures for han chinese breast cancers. Chi-Cheng Huang, Shih-Hsin Tu, +5 authors, Eric Y Chuang. less PLoS One, 2013 Oct 08; 8(10). PMID: 24098497 Free PMC article.
Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection. Trine Tramm, Guido Hennig, +5 authors, Jens Overgaard. less Virchows Arch, 2013 Oct 09; 463(6). PMID: 24100522
Evaluating the 21-gene assay Recurrence Score® as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer. Takayuki Ueno, Norikazu Masuda, +12 authors, Masakazu Toi. less Int J Clin Oncol, 2013 Oct 09; 19(4). PMID: 24101215
Analytical validation of the Oncotype DX prostate cancer assay - a clinical RT-PCR assay optimized for prostate needle biopsies. Dejan Knezevic, Audrey D Goddard, +8 authors, Christopher Quale. less BMC Genomics, 2013 Oct 10; 14. PMID: 24103217 Free PMC article. Highly Cited.
A robust prognostic signature for hormone-positive node-negative breast cancer. Obi L Griffith, François Pepin, +4 authors, Joe W Gray. less Genome Med, 2013 Oct 12; 5(10). PMID: 24112773 Free PMC article.
Multiplatform single-sample estimates of transcriptional activation. Stephen R Piccolo, Michelle R Withers, +2 authors, Owen E Francis, Andrea H Bild, W Evan Johnson. less Proc Natl Acad Sci U S A, 2013 Oct 17; 110(44). PMID: 24128763 Free PMC article.
Genomics: Comparisons across cancers. Alan Ashworth, Thomas J Hudson. Nature, 2013 Oct 18; 502(7471). PMID: 24132284
Benefit risk assessment and update on the use of docetaxel in the management of breast cancer. Scheryll Alken, Catherine M Kelly. Cancer Manag Res, 2013 Oct 22; 5. PMID: 24143122 Free PMC article. Review.
Genomic instability: a stronger prognostic marker than proliferation for early stage luminal breast carcinomas. Anne Vincent-Salomon, Vanessa Benhamo, +13 authors, Olivier Delattre. less PLoS One, 2013 Oct 22; 8(10). PMID: 24143191 Free PMC article.
Prognostic value of the nodal ratio and ki-67 expression in breast cancer patients treated with postmastectomy radiotherapy. Tae Ryool Koo, Keun Yong Eom, +5 authors, In Ah Kim. less J Breast Cancer, 2013 Oct 25; 16(3). PMID: 24155756 Free PMC article.
Molecular diagnosis for personalized target therapy in gastric cancer. Jae Yong Cho. J Gastric Cancer, 2013 Oct 25; 13(3). PMID: 24156032 Free PMC article. Review.
The EndoPredict score provides prognostic information on late distant metastases in ER+/HER2- breast cancer patients. P Dubsky, J C Brase, +18 authors, Austrian Breast and Colorectal Cancer Study Group (ABCSG). less Br J Cancer, 2013 Oct 26; 109(12). PMID: 24157828 Free PMC article. Highly Cited.
Plasma proteomics analysis of tamoxifen resistance in breast cancer. Keivan Majidzadeh-A, Javad Gharechahi. Med Oncol, 2013 Oct 26; 30(4). PMID: 24158757
PROGgene: gene expression based survival analysis web application for multiple cancers. Chirayu Pankaj Goswami, Harikrishna Nakshatri. J Clin Bioinforma, 2013 Oct 30; 3(1). PMID: 24165311 Free PMC article. Highly Cited.
An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk. Christina Yau, John Sninsky, +9 authors, Christopher C Benz. less Breast Cancer Res, 2013 Nov 01; 15(5). PMID: 24172169 Free PMC article.
In situ Protein Detection for Companion Diagnostics. Gabriela Gremel, Karin Grannas, +2 authors, Lesley Ann Sutton, Fredrik Pontén, Agata Zieba. less Front Oncol, 2013 Nov 08; 3. PMID: 24199171 Free PMC article. Review.
A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer. Dong-Joo Cheon, Yunguang Tong, +9 authors, Sandra Orsulic. less Clin Cancer Res, 2013 Nov 13; 20(3). PMID: 24218511 Free PMC article. Highly Cited.
Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration. Lisa M McShane, Margaret M Cavenagh, +12 authors, Barbara A Conley. less BMC Med, 2013 Nov 16; 11. PMID: 24228635 Free PMC article.
Molecular profiling for breast cancer: a comprehensive review. Muaiad Kittaneh, Alberto J Montero, Stefan Glück. Biomark Cancer, 2013 Nov 20; 5. PMID: 24250234 Free PMC article. Review.
An unmet need: tailoring extended adjuvant endocrine therapy. G Bianchini, L Gianni. Br J Cancer, 2013 Nov 21; 109(12). PMID: 24253504 Free PMC article.
Construction and analysis of multiparameter prognostic models for melanoma outcome. Bonnie E Gould Rothberg, David L Rimm. Methods Mol Biol, 2013 Nov 22; 1102. PMID: 24258982 Free PMC article. Systematic Review.
Predicting degree of benefit from adjuvant trastuzumab in NSABP trial B-31. Katherine L Pogue-Geile, Chungyeul Kim, +26 authors, Soonmyung Paik. less J Natl Cancer Inst, 2013 Nov 23; 105(23). PMID: 24262440 Free PMC article.
Two-gene expression ratio as predictor for breast cancer treated with tamoxifen: evidence from meta-analysis. Lin Zhao, Shimiao Zhu, Ying Gao, Yaogang Wang. Tumour Biol, 2013 Nov 23; 35(4). PMID: 24264313
Prognostic factors in elderly patients with breast cancer. Alessandro Cappellani, Maria Di Vita, +5 authors, Massimiliano Berretta. less BMC Surg, 2013 Dec 07; 13 Suppl 2. PMID: 24268048 Free PMC article. Review.
Correlation between ER, PR, HER-2, Bcl-2, p53, proliferative and apoptotic indexes with HER-2 gene amplification and TOP2A gene amplification and deletion in four molecular subtypes of breast cancer. Olivera Mitrović, Vladan Čokić, +6 authors, Snežana Furtula. less Target Oncol, 2013 Nov 26; 9(4). PMID: 24272208
Biomarker enrichment strategies: matching trial design to biomarker credentials. Boris Freidlin, Edward L Korn. Nat Rev Clin Oncol, 2013 Nov 28; 11(2). PMID: 24281059 Review.
Biomarkers for Basal-like Breast Cancer. Jennifer R Choo, Torsten O Nielsen. Cancers (Basel), 2010 Jan 01; 2(2). PMID: 24281106 Free PMC article.
MicroRNAs and triple negative breast cancer. Elvira D'Ippolito, Marilena V Iorio. Int J Mol Sci, 2013 Nov 29; 14(11). PMID: 24284394 Free PMC article. Review.
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Suzanne A Eccles, Eric O Aboagye, +84 authors, Alastair M Thompson. less Breast Cancer Res, 2013 Nov 30; 15(5). PMID: 24286369 Free PMC article. Highly Cited. Review.
Cost effectiveness of a 21-gene recurrence score assay versus Canadian clinical practice in post-menopausal women with early-stage estrogen or progesterone-receptor-positive, axillary lymph-node positive breast cancer. Malek B Hannouf, Bin Xie, Muriel Brackstone, Gregory S Zaric. Pharmacoeconomics, 2013 Nov 30; 32(2). PMID: 24288208
Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival. F Bertucci, N T Ueno, +16 authors, S J Van Laere. less Ann Oncol, 2013 Dec 05; 25(2). PMID: 24299959 Free PMC article.
Prognostic discrimination using a 70-gene signature among patients with estrogen receptor-positive breast cancer and an intermediate 21-gene recurrence score. Sung Gwe Ahn, Hak Min Lee, +5 authors, In-Sun Chu. less Int J Mol Sci, 2013 Dec 07; 14(12). PMID: 24304542 Free PMC article.
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. Atsushi Terunuma, Nagireddy Putluri, +31 authors, Stefan Ambs. less J Clin Invest, 2013 Dec 10; 124(1). PMID: 24316975 Free PMC article. Highly Cited.
Pathway analyses and understanding disease associations. Yu Liu, Mark R Chance. Curr Genet Med Rep, 2013 Dec 10; 1(4). PMID: 24319650 Free PMC article.
The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer. Marie Klintman, Carina Strand, +11 authors, Mårten Fernö. less PLoS One, 2013 Dec 11; 8(12). PMID: 24324728 Free PMC article.
A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients. Unjin Lee, Casey Frankenberger, +6 authors, Marsha Rich Rosner. less PLoS One, 2013 Dec 19; 8(12). PMID: 24349199 Free PMC article.
Magnetic resonance metabolic profiling of breast cancer tissue obtained with core needle biopsy for predicting pathologic response to neoadjuvant chemotherapy. Ji Soo Choi, Hyeon-Man Baek, +5 authors, Youn Ki Nam. less PLoS One, 2013 Dec 25; 8(12). PMID: 24367616 Free PMC article.
The impact of the Oncotype DX Recurrence Score on treatment decisions and clinical outcomes in patients with early breast cancer: the Maccabi Healthcare Services experience with a unified testing policy. Nava Siegelmann-Danieli, Barbara Silverman, +3 authors, Avi Porath. less Ecancermedicalscience, 2014 Jan 05; 7. PMID: 24386009 Free PMC article.
Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease. Asha Thomas, Umesh Mahantshetty, +4 authors, Rita Mulherkar. less Cancer Med, 2014 Jan 10; 2(6). PMID: 24403257 Free PMC article.
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients. Anna Tessari, Dario Palmieri, Serena Di Cosimo. Pharmgenomics Pers Med, 2014 Jan 10; 7. PMID: 24403841 Free PMC article. Review.
Neoadjuvant Hormonal Therapy is Associated with Comparable Outcomes to Neoadjuvant Chemotherapy in Post-Menopausal Women with Estrogen Receptor-Positive Breast Cancer. David M Marcus, Jeffrey M Switchenko, +5 authors, Mylin A Torres. less Front Oncol, 2014 Jan 11; 3. PMID: 24409418 Free PMC article.
Comparison of study designs used to detect and characterize pharmacogenomic interactions in nonexperimental studies: a simulation study. Christy L Avery, Jane S Der, Eric A Whitsel, Til Stürmer. Pharmacogenet Genomics, 2014 Jan 15; 24(3). PMID: 24413365 Free PMC article.
AGO Recommendations for Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2013. Anton Scharl, Christoph Thomssen, Nadia Harbeck, Volkmar Müller. Breast Care (Basel), 2014 Jan 15; 8(3). PMID: 24415966 Free PMC article.
Breast Cancer Biomarkers: Utility in Clinical Practice. Fanny Le Du, Naoto T Ueno, Ana M Gonzalez-Angulo. Curr Breast Cancer Rep, 2014 Jan 15; 5(4). PMID: 24416469 Free PMC article.
Reply to E.J. Moylan et al. Sandra M Swain, Gong Tang, Charles E Geyer. J Clin Oncol, 2014 Jan 15; 32(6). PMID: 24419136 Free PMC article.
Galectin-3 disruption impaired tumoral angiogenesis by reducing VEGF secretion from TGFβ1-induced macrophages. Camila Maria Longo Machado, Luciana Nogueira Sousa Andrade, +8 authors, Roger Chammas. less Cancer Med, 2014 Jan 15; 3(2). PMID: 24421272 Free PMC article.
Timing of determining axillary lymph node status when neoadjuvant chemotherapy is used. Eleftherios P Mamounas. Curr Oncol Rep, 2014 Jan 22; 16(2). PMID: 24445496 Free PMC article. Review.
Oncotype dx results in multiple primary breast cancers. Michael J Toole, Kelley M Kidwell, Catherine Van Poznak. Breast Cancer (Auckl), 2014 Jan 24; 8. PMID: 24453493 Free PMC article.
Validation of proposed prostate cancer biomarkers with gene expression data: a long road to travel. Adriana Amaro, Alessia Isabella Esposito, +4 authors, Ulrich Pfeffer. less Cancer Metastasis Rev, 2014 Jan 31; 33(2-3). PMID: 24477410 Free PMC article. Review.
Molecular tests as prognostic factors in breast cancer. Marc J van de Vijver. Virchows Arch, 2014 Feb 04; 464(3). PMID: 24487789 Review.
Regularized Multivariate Regression for Identifying Master Predictors with Application to Integrative Genomics Study of Breast Cancer. Jie Peng, Ji Zhu, +4 authors, Pei Wang. less Ann Appl Stat, 2010 Mar 01; 4(1). PMID: 24489618 Free PMC article.
Accurate data processing improves the reliability of Affymetrix gene expression profiles from FFPE samples. Maurizio Callari, Antonio Lembo, +5 authors, Paolo Provero. less PLoS One, 2014 Feb 04; 9(1). PMID: 24489733 Free PMC article.
Breast tumor subgroups reveal diverse clinical prognostic power. Zhaoqi Liu, Xiang-Sun Zhang, Shihua Zhang. Sci Rep, 2014 Feb 07; 4. PMID: 24499868 Free PMC article.
Development and validation of a gene expression score that predicts response to fulvestrant in breast cancer patients. Steen Knudsen, Thomas Jensen, +5 authors, Elizabeth Anderson. less PLoS One, 2014 Feb 08; 9(2). PMID: 24505287 Free PMC article.
Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy. Wen Zhou, Joyce M Slingerland. Nat Rev Cancer, 2014 Feb 08; 14(1). PMID: 24505618 Review.
Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity. Denise M Wolf, Marc E Lenburg, +2 authors, Christina Yau, Aaron Boudreau, Laura J van 't Veer. less PLoS One, 2014 Feb 12; 9(2). PMID: 24516633 Free PMC article.
Intrinsic subtypes from the PAM50 gene expression assay in a population-based breast cancer survivor cohort: prognostication of short- and long-term outcomes. Bette J Caan, Carol Sweeney, +8 authors, Philip S Bernard. less Cancer Epidemiol Biomarkers Prev, 2014 Feb 14; 23(5). PMID: 24521998 Free PMC article.
Radiation-induced gene signature predicts pathologic complete response to neoadjuvant chemotherapy in breast cancer patients. Daniel S Oh, Maggie C U Cheang, Cheng Fan, Charles M Perou. Radiat Res, 2014 Feb 18; 181(2). PMID: 24527691 Free PMC article.
Genomic profiling in luminal breast cancer. Oleg Gluz, Daniel Hofmann, +3 authors, Nadia Harbeck. less Breast Care (Basel), 2014 Feb 20; 8(6). PMID: 24550749 Free PMC article. Review.
Which threshold for ER positivity? a retrospective study based on 9639 patients. M Yi, L Huo, +11 authors, K K Hunt. less Ann Oncol, 2014 Feb 25; 25(5). PMID: 24562447 Free PMC article.
A Majority of Low (1-10%) ER Positive Breast Cancers Behave Like Hormone Receptor Negative Tumors. Jyothi S Prabhu, Aruna Korlimarla, +12 authors, T S Sridhar. less J Cancer, 2014 Feb 25; 5(2). PMID: 24563670 Free PMC article.
Treatment decisions in estrogen receptor-positive early breast cancer patients with intermediate oncotype DX recurrence score results. Georgeta Fried, Mor Moskovitz. Springerplus, 2014 Feb 26; 3. PMID: 24567880 Free PMC article.
Personalized medicine: risk prediction, targeted therapies and mobile health technology. Daniel F Hayes, Hugh S Markus, R David Leslie, Eric J Topol. BMC Med, 2014 Mar 04; 12. PMID: 24580858 Free PMC article. Review.
Identification of a 251 gene expression signature that can accurately detect M. tuberculosis in patients with and without HIV co-infection. Noor Dawany, Louise C Showe, +7 authors, Luis J Montaner. less PLoS One, 2014 Mar 04; 9(2). PMID: 24587128 Free PMC article.
Gene expression analysis in RA: towards personalized medicine. A N Burska, K Roget, +8 authors, F Ponchel. less Pharmacogenomics J, 2014 Mar 05; 14(2). PMID: 24589910 Free PMC article. Review.
Prognostic value of gene signatures and proliferation in lymph-node-negative breast cancer. Kristin Jonsdottir, Jörg Assmus, +4 authors, Emiel A M Janssen. less PLoS One, 2014 Mar 07; 9(3). PMID: 24599057 Free PMC article.
Novel combination markers for predicting survival in patients with muscle invasive bladder cancer: USP18 and DGCR2. Ye-Hwan Kim, Won Tae Kim, +7 authors, Wun-Jae Kim. less J Korean Med Sci, 2014 Mar 13; 29(3). PMID: 24616583 Free PMC article.
Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer. E A Rakha, D Soria, +6 authors, I O Ellis. less Br J Cancer, 2014 Mar 13; 110(7). PMID: 24619074 Free PMC article.
CCNA2 is a prognostic biomarker for ER+ breast cancer and tamoxifen resistance. Tian Gao, Yong Han, +3 authors, Ling Yu, Sheng Ao, Ziyu Li, Jiafu Ji. less PLoS One, 2014 Mar 14; 9(3). PMID: 24622579 Free PMC article.
Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens. Torsten Nielsen, Brett Wallden, +7 authors, James Storhoff. less BMC Cancer, 2014 Mar 15; 14. PMID: 24625003 Free PMC article. Highly Cited.
Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients. Nicholas P Tobin, Linda S Lindström, +3 authors, Kristian Wennmalm. less Mol Oncol, 2014 Mar 19; 8(3). PMID: 24630985 Free PMC article.
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Janna K Mouw, Yoshihiro Yui, +10 authors, Valerie M Weaver. less Nat Med, 2014 Mar 19; 20(4). PMID: 24633304 Free PMC article. Highly Cited.
Inferring gene dependency network specific to phenotypic alteration based on gene expression data and clinical information of breast cancer. Xionghui Zhou, Juan Liu. PLoS One, 2014 Mar 19; 9(3). PMID: 24637666 Free PMC article.
A supervised network analysis on gene expression profiles of breast tumors predicts a 41-gene prognostic signature of the transcription factor MYB across molecular subtypes. Li-Yu D Liu, Li-Yun Chang, +3 authors, Fon-Jou Hsieh. less Comput Math Methods Med, 2014 Mar 19; 2014. PMID: 24639887 Free PMC article.
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status. Xi Zhao, Einar Andreas Rødland, +5 authors, Anne-Lise Børresen-Dale. less BMC Cancer, 2014 Mar 22; 14. PMID: 24645668 Free PMC article.
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review). Mei Hong Zhang, Hong Tao Man, +2 authors, Xiao Dan Zhao, Ni Dong, Shi Liang Ma. less Biomed Rep, 2014 Mar 22; 2(1). PMID: 24649067 Free PMC article.
Collagen gel droplet-embedded culture-drug sensitivity test and Ki67 expression in estrogen receptor-positive and HER2-negative breast cancer. Katsunori Tozuka, Jun Horiguchi, +7 authors, Izumi Takeyoshi. less Mol Clin Oncol, 2013 Jan 01; 1(1). PMID: 24649129 Free PMC article.
Evaluation and correlation of risk recurrence in early breast cancer assessed by Oncotype DX®, clinicopathological markers and tumor cell dissemination in the blood and bone marrow. Bahriye Aktas, Agnes Bankfalvi, +2 authors, Martin Heubner, Rainer Kimmig, Sabine Kasimir-Bauer. less Mol Clin Oncol, 2014 Mar 22; 1(6). PMID: 24649291 Free PMC article.
Implications of functional proteomics in breast cancer. Young Kwang Chae, Ana Maria Gonzalez-Angulo. Oncologist, 2014 Mar 26; 19(4). PMID: 24664486 Free PMC article. Review.
Adaptive designs for clinical trials assessing biomarker-guided treatment strategies. J Wason, A Marshall, +2 authors, J Dunn, R C Stein, N Stallard. less Br J Cancer, 2014 Mar 29; 110(8). PMID: 24667651 Free PMC article.
A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Michael D Onken, Ashley E Winkler, +10 authors, Ravindra Uppaluri. less Clin Cancer Res, 2014 Mar 29; 20(11). PMID: 24668645 Free PMC article.
Clinical prediction rules in practice: review of clinical guidelines and survey of GPs. Annette Plüddemann, Emma Wallace, +13 authors, Richard Stevens. less Br J Gen Pract, 2014 Apr 02; 64(621). PMID: 24686888 Free PMC article. Review.
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Predictive performance of microarray gene signatures: impact of tumor heterogeneity and multiple mechanisms of drug resistance. Charlotte K Y Ng, Britta Weigelt, +5 authors, Jorge S Reis-Filho. less Cancer Res, 2014 Apr 08; 74(11). PMID: 24706696 Free PMC article.
Next generation DNA sequencing and the future of genomic medicine. Matthew W Anderson, Iris Schrijver. Genes (Basel), 2010 Jan 01; 1(1). PMID: 24710010 Free PMC article.
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APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation. David W Cescon, Benjamin Haibe-Kains, Tak W Mak. Proc Natl Acad Sci U S A, 2015 Mar 03; 112(9). PMID: 25730878 Free PMC article. Highly Cited.
Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer. Purificacion Estevez-Garcia, Fernando Rivera, +8 authors, Rocio Garcia-Carbonero. less Oncotarget, 2015 Mar 03; 6(8). PMID: 25730906 Free PMC article.
How can we best respect patient autonomy in breast cancer treatment decisions? Kathryn A Martinez, Allison W Kurian, Sarah T Hawley, Reshma Jagsi. Breast Cancer Manag, 2015 Mar 04; 4(1). PMID: 25733982 Free PMC article.
Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates. Kelly E Burns, Matthew K Robinson, Damien Thévenin. Mol Pharm, 2015 Mar 06; 12(4). PMID: 25741818 Free PMC article.
The value of personalizing medicine: medical oncologists' views on gene expression profiling in breast cancer treatment. Yvonne Bombard, Linda Rozmovits, +3 authors, Deborah A Marshall. less Oncologist, 2015 Mar 10; 20(4). PMID: 25746345 Free PMC article.
Machine learning applications in cancer prognosis and prediction. Konstantina Kourou, Themis P Exarchos, +2 authors, Dimitrios I Fotiadis. less Comput Struct Biotechnol J, 2015 Mar 10; 13. PMID: 25750696 Free PMC article. Highly Cited. Review.
Network-based approach to identify prognostic biomarkers for estrogen receptor-positive breast cancer treatment with tamoxifen. Rong Liu, Cheng-Xian Guo, Hong-Hao Zhou. Cancer biology & therapy, 2015 Mar 11; 16(2). PMID: 25756514 Free PMC article.
Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease. Maurice P H M Jansen, Leen Sas, +20 authors, Steven Van Laere. less Mol Oncol, 2015 Mar 17; 9(6). PMID: 25771305 Free PMC article.
Integrated analysis of DNA methylation, immunohistochemistry and mRNA expression, data identifies a methylation expression index (MEI) robustly associated with survival of ER-positive breast cancer patients. Jonine D Figueroa, Howard Yang, +6 authors, Maxwell Lee. less Breast Cancer Res Treat, 2015 Mar 17; 150(2). PMID: 25773928 Free PMC article.
A retrospective study of the impact of 21-gene recurrence score assay on treatment choice in node positive micrometastatic breast cancer. Thomas G Frazier, Kevin R Fox, +13 authors, Michael S Broder. less Pharmaceuticals (Basel), 2015 Mar 20; 8(1). PMID: 25789420 Free PMC article.
In the era of genomics, should tumor size be reconsidered as a criterion for neoadjuvant chemotherapy? Xavier Pivot, Laura Mansi, +14 authors, Christian Villanueva. less Oncologist, 2015 Mar 22; 20(4). PMID: 25795632 Free PMC article.
Breast cancer under age 40: a different approach. D Ribnikar, J M Ribeiro, +6 authors, F Cardoso. less Curr Treat Options Oncol, 2015 Mar 23; 16(4). PMID: 25796377 Review.
Comprehensive molecular screening: from the RT-PCR to the RNA-seq. Carlota Costa, Ana Giménez-Capitán, Niki Karachaliou, Rafael Rosell. Transl Lung Cancer Res, 2013 Apr 01; 2(2). PMID: 25806219 Free PMC article. Review.
Retrospective analysis of metastatic behaviour of breast cancer subtypes. C Dilara Savci-Heijink, Hans Halfwerk, +3 authors, Marc J van de Vijver. less Breast Cancer Res Treat, 2015 Mar 31; 150(3). PMID: 25820592 Free PMC article.
Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures. Angelika Modelska, Alessandro Quattrone, Angela Re. Brief Bioinform, 2015 Apr 03; 16(6). PMID: 25832647 Free PMC article. Review.
A phase 1 trial of preoperative partial breast radiation therapy: Patient selection, target delineation, and dose delivery. Rachel C Blitzblau, Ritu Arya, +5 authors, Janet K Horton. less Pract Radiat Oncol, 2015 Apr 04; 5(5). PMID: 25834942 Free PMC article.
[Molecular pathology for breast cancer: Importance of the gene expression profile]. C Denkert, B M Pfitzner, B I Heppner, M Dietel. Pathologe, 2015 Apr 04; 36(2). PMID: 25836324 Review.
An integrated quantification method to increase the precision, robustness, and resolution of protein measurement in human plasma samples. Xiao-Jun Li, Lik Wee Lee, +8 authors, Paul Kearney. less Clin Proteomics, 2015 Apr 04; 12(1). PMID: 25838814 Free PMC article.
Multigene prognostic tests in breast cancer: past, present, future. Balázs Győrffy, Christos Hatzis, +3 authors, Lajos Pusztai. less Breast Cancer Res, 2015 Apr 08; 17. PMID: 25848861 Free PMC article. Highly Cited. Review.
Markers for the identification of late breast cancer recurrence. Ivana Sestak, Jack Cuzick. Breast Cancer Res, 2015 Apr 08; 17. PMID: 25848913 Free PMC article. Review.
Molecular subtyping for clinically defined breast cancer subgroups. Xi Zhao, Einar Andreas Rødland, Robert Tibshirani, Sylvia Plevritis. Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849221 Free PMC article.
Patient-derived xenograft models of breast cancer and their predictive power. James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader. Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849559 Free PMC article. Highly Cited. Review.
Breast cancer subtype intertumor heterogeneity: MRI-based features predict results of a genomic assay. Elizabeth J Sutton, Jung Hun Oh, +5 authors, Elizabeth A Morris. less J Magn Reson Imaging, 2015 Apr 09; 42(5). PMID: 25850931 Free PMC article. Highly Cited.
Integrative analysis of survival-associated gene sets in breast cancer. Frederick S Varn, Matthew H Ung, Shao Ke Lou, Chao Cheng. BMC Med Genomics, 2015 Apr 17; 8. PMID: 25881247 Free PMC article.
Prognostic value of a 92-probe signature in breast cancer. Salima Akter, Tae Gyu Choi, +17 authors, Sung Soo Kim. less Oncotarget, 2015 Apr 18; 6(17). PMID: 25883221 Free PMC article.
Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value. Brian David Lehmann, Yan Ding, +6 authors, Yajun Yi. less BMC Cancer, 2015 Apr 18; 15. PMID: 25886164 Free PMC article.
Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer--the INNODIAG study. Tatiana Kempowsky-Hamon, Carine Valle, +12 authors, Véronique Anton-Leberre. less BMC Med Genomics, 2015 Apr 19; 8. PMID: 25888889 Free PMC article.
FKBPL: a marker of good prognosis in breast cancer. Laura Nelson, Hayley D McKeen, +27 authors, Tracy Robson. less Oncotarget, 2015 Apr 25; 6(14). PMID: 25906750 Free PMC article.
Defining breast cancer intrinsic subtypes by quantitative receptor expression. Maggie C U Cheang, Miguel Martin, +21 authors, Lisa A Carey. less Oncologist, 2015 Apr 25; 20(5). PMID: 25908555 Free PMC article.
OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer. Jae-Hwan Kim, Soon-Min Lee, +9 authors, Hong-Duk Youn. less Oncotarget, 2015 Apr 25; 6(23). PMID: 25909288 Free PMC article.
Insulin-like growth factor-1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression. Young Wha Koh, Dok Hyun Yoon, +2 authors, Cheolwon Suh, Hee Jeong Cha, Jooryung Huh. less Int J Exp Pathol, 2015 Apr 29; 96(4). PMID: 25916750 Free PMC article.
Developing a new generation of breast cancer clinical gene expression tests. Zuzana Kos, Torsten O Nielsen. Breast Cancer Res, 2014 Jan 01; 16(4). PMID: 25928431 Free PMC article.
Use of modified Magee equations and histologic criteria to predict the Oncotype DX recurrence score. Bradley M Turner, Kristin A Skinner, +6 authors, David G Hicks. less Mod Pathol, 2015 May 02; 28(7). PMID: 25932962
Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer. Xiaolan Feng, Haocheng Li, +8 authors, Gwyn Bebb. less Breast Cancer Res, 2015 May 04; 17. PMID: 25935535 Free PMC article.
Comparing Platforms for Messenger RNA Expression Profiling of Archival Formalin-Fixed, Paraffin-Embedded Tissues. Svitlana Tyekucheva, Neil E Martin, +10 authors, Michael Birrer. less J Mol Diagn, 2015 May 06; 17(4). PMID: 25937617 Free PMC article.
Role of genetic and molecular profiling in sarcomas. Scott M Norberg, Sujana Movva. Curr Treat Options Oncol, 2015 May 06; 16(5). PMID: 25939540 Review.
Association between ¹⁸F-FDG uptake and molecular subtype of breast cancer. Kazuhiro Kitajima, Kazuhito Fukushima, +6 authors, Shozo Hirota. less Eur J Nucl Med Mol Imaging,

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