Journal Article
. 2004 Dec; 102(2):419-24.
doi: 10.1073/pnas.0408197102.

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo

Mei-Ling Chen 1 Mikaël J Pittet  Leonid Gorelik  Richard A Flavell  Ralph Weissleder  Harald von Boehmer  Khashayarsha Khazaie  
  • PMID: 15623559
  •     41 References
  •     275 citations


Cancer patients can harbor significant numbers of CD8 and CD4 T cells with specificities to tumor antigens (Ags). Yet, in most cases, such T cells fail to eradicate the tumor in vivo. Here, we investigated the interference of Ag-specific CD4(+)CD25(+) regulatory T cells (Treg) with the tumor-specific CD8 T cell immune response in vivo, by monitoring the homing, expansion, and effector function of both subsets in draining and nondraining lymph nodes. The results show that CD8 cells expand to the same extent and produce similar levels of IFN-gamma in the presence or absence of Ag-specific Treg. Nevertheless, these Treg abrogate CD8 T cell-mediated tumor rejection by specifically suppressing the cytotoxicity of expanded CD8 cells. The molecular mechanism of suppression involves TGF-beta because expression of a dominant-negative TGF-beta receptor by tumor-specific CD8 cells renders them resistant to suppression and is associated with tumor rejection and unimpaired cytotoxicity.

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease.
L Gorelik, R A Flavell.
Immunity, 2000 Mar 14; 12(2). PMID: 10714683
Highly Cited.
Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta.
M J Smyth, S L Strobl, +2 authors, A C Ochoa.
J Immunol, 1991 May 15; 146(10). PMID: 1827481
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.
V Shankaran, H Ikeda, +4 authors, R D Schreiber.
Nature, 2001 Apr 27; 410(6832). PMID: 11323675
Highly Cited.
Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells.
C A Piccirillo, E M Shevach.
J Immunol, 2001 Jul 24; 167(3). PMID: 11466326
Highly Cited.
Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells.
L Gorelik, R A Flavell.
Nat Med, 2001 Oct 09; 7(10). PMID: 11590434
Highly Cited.
CD25+CD4+ T cells contribute to the control of memory CD8+ T cells.
Masaaki Murakami, Akemi Sakamoto, +2 authors, Philippa Marrack.
Proc Natl Acad Sci U S A, 2002 Jun 27; 99(13). PMID: 12084927    Free PMC article.
Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.
J Kirberg, A Baron, +3 authors, H von Boehmer.
J Exp Med, 1994 Jul 01; 180(1). PMID: 8006585    Free PMC article.
Highly Cited.
Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.
S Valitutti, S Müller, M Dessing, A Lanzavecchia.
J Exp Med, 1996 Apr 01; 183(4). PMID: 8666949    Free PMC article.
Highly Cited.
CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.
D J Morgan, R Liblau, +5 authors, L A Sherman.
J Immunol, 1996 Aug 01; 157(3). PMID: 8757600
Highly Cited.
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.
E Suri-Payer, A Z Amar, A M Thornton, E M Shevach.
J Immunol, 1998 May 07; 160(3). PMID: 9570536
Highly Cited.
Presence or absence of TGF-beta determines IL-4-induced generation of type 1 or type 2 CD8 T cell subsets.
F Erard, J A Garcia-Sanz, R Moriggl, M T Wild.
J Immunol, 1999 Jan 14; 162(1). PMID: 9886388
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes.
Yufeng Peng, Yasmina Laouar, +2 authors, Richard A Flavell.
Proc Natl Acad Sci U S A, 2004 Apr 09; 101(13). PMID: 15070759    Free PMC article.
Highly Cited.
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.
Ciriaco A Piccirillo, John J Letterio, +4 authors, Ethan M Shevach.
J Exp Med, 2002 Jul 18; 196(2). PMID: 12119348    Free PMC article.
Highly Cited.
Origin of regulatory T cells with known specificity for antigen.
Irina Apostolou, Adelaida Sarukhan, Ludger Klein, Harald von Boehmer.
Nat Immunol, 2002 Jun 29; 3(8). PMID: 12089509
Highly Cited.
Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens.
Javier Hernández, Sandra Aung, Kristi Marquardt, Linda A Sherman.
J Exp Med, 2002 Aug 07; 196(3). PMID: 12163561    Free PMC article.
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.
Thomas R Malek, Aixin Yu, +2 authors, Lin Kong.
Immunity, 2002 Aug 28; 17(2). PMID: 12196288
Highly Cited.
Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta.
Rajasekharan Somasundaram, Lutz Jacob, +13 authors, Dorothee Herlyn.
Cancer Res, 2002 Sep 18; 62(18). PMID: 12234995
Functional significance of the perforin/granzyme cell death pathway.
Joseph A Trapani, Mark J Smyth.
Nat Rev Immunol, 2002 Oct 03; 2(10). PMID: 12360212
Highly Cited. Review.
Dominant transplantation tolerance impairs CD8+ T cell function but not expansion.
Chun-Yen Lin, Luis Graca, Stephen P Cobbold, Herman Waldmann.
Nat Immunol, 2002 Nov 05; 3(12). PMID: 12415266
Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses.
Mischo Kursar, Kerstin Bonhagen, +5 authors, Hans-Willi Mittrücker.
J Exp Med, 2002 Dec 18; 196(12). PMID: 12486101    Free PMC article.
Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.
Jennifer E Snyder, William J Bowers, +3 authors, Tim R Mosmann.
Nat Med, 2003 Jan 23; 9(2). PMID: 12539041
Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor.
Ludger Klein, Lydie Trautman, +5 authors, Khashayarsha Khazaie.
Eur J Immunol, 2003 Mar 05; 33(3). PMID: 12616501
The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis.
Thomas Blankenstein, Zhihai Qin.
Curr Opin Immunol, 2003 Mar 14; 15(2). PMID: 12633663
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells.
J Rodrigo Mora, Maria Rosa Bono, +4 authors, Ulrich H Von Andrian.
Nature, 2003 Jul 04; 424(6944). PMID: 12840763
Highly Cited.
A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells.
Zhihai Qin, Johannes Schwartzkopff, +4 authors, Thomas Blankenstein.
Cancer Res, 2003 Jul 23; 63(14). PMID: 12874012
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells.
Sayuri Yamazaki, Tomonori Iyoda, +4 authors, Ralph M Steinman.
J Exp Med, 2003 Jul 23; 198(2). PMID: 12874257    Free PMC article.
Highly Cited.
Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.
Lucy S K Walker, Anna Chodos, +2 authors, Abul K Abbas.
J Exp Med, 2003 Jul 23; 198(2). PMID: 12874258    Free PMC article.
Highly Cited.
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro.
Ludger Klein, Khashayarsha Khazaie, Harald von Boehmer.
Proc Natl Acad Sci U S A, 2003 Jul 15; 100(15). PMID: 12857946    Free PMC article.
Highly Cited.
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.
Sylvain Fisson, Guillaume Darrasse-Jèze, +4 authors, Benoît L Salomon.
J Exp Med, 2003 Aug 27; 198(5). PMID: 12939344    Free PMC article.
Highly Cited.
Dynamics of suppressor T cells: in vivo veritas.
Harald von Boehmer.
J Exp Med, 2003 Sep 17; 198(6). PMID: 12975452    Free PMC article.
CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses.
Susmit Suvas, Uday Kumaraguru, +2 authors, Barry T Rouse.
J Exp Med, 2003 Sep 17; 198(6). PMID: 12975455    Free PMC article.
Highly Cited.
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes.
E Allison Green, Leonid Gorelik, +2 authors, Richard A Flavell.
Proc Natl Acad Sci U S A, 2003 Sep 02; 100(19). PMID: 12949259    Free PMC article.
Highly Cited.
CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism.
Zhenhua Dai, Qi Li, +4 authors, Fadi G Lakkis.
J Clin Invest, 2004 Jan 15; 113(2). PMID: 14722622    Free PMC article.
Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy.
Helen Y Wang, Dean A Lee, +5 authors, Rong Fu Wang.
Immunity, 2004 Jan 24; 20(1). PMID: 14738769
Highly Cited.
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection.
Ulf Dittmer, Hong He, +11 authors, Kim J Hasenkrug.
Immunity, 2004 Mar 20; 20(3). PMID: 15030773
Highly Cited.
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.
Shimon Sakaguchi.
Annu Rev Immunol, 2004 Mar 23; 22. PMID: 15032588
Highly Cited. Review.
Regulatory T cells. Introduction.
E M Shevach.
Semin Immunol, 2004 Mar 24; 16(2). PMID: 15036229
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance.
Alfred Zippelius, Pascal Batard, +13 authors, Mikaël J Pittet.
Cancer Res, 2004 Apr 17; 64(8). PMID: 15087405
Highly Cited.
A spontaneously arising pancreatic tumor does not promote the differentiation of naive CD8+ T lymphocytes into effector CTL.
Michael A Lyman, Sandra Aung, Judith A Biggs, Linda A Sherman.
J Immunol, 2004 May 22; 172(11). PMID: 15153470
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J Curiel, George Coukos, +18 authors, Weiping Zou.
Nat Med, 2004 Aug 24; 10(9). PMID: 15322536
Highly Cited.
Response of naïve and memory CD8+ T cells to antigen stimulation in vivo.
H Veiga-Fernandes, U Walter, +2 authors, B Rocha.
Nat Immunol, 2001 Mar 23; 1(1). PMID: 10881174
Highly Cited.
CD4+ regulatory cells as a potential immunotherapy.
Zoltán Fehérvari, Shimon Sakaguchi.
Philos Trans R Soc Lond B Biol Sci, 2005 Sep 09; 360(1461). PMID: 16147529    Free PMC article.
Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines.
Gang Zhou, Charles G Drake, Hyam I Levitsky.
Blood, 2005 Sep 24; 107(2). PMID: 16179369    Free PMC article.
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
Zhibin Chen, Ann E Herman, +2 authors, Christophe Benoist.
J Exp Med, 2005 Nov 23; 202(10). PMID: 16301745    Free PMC article.
Highly Cited.
In vivo sites and cellular mechanisms of T reg cell-mediated suppression.
Alexander Y Rudensky, Daniel J Campbell.
J Exp Med, 2006 Mar 15; 203(3). PMID: 16533888    Free PMC article.
T regulatory cell suppression of colitis: the role of TGF-beta.
R Duchmann, M Zeitz.
Gut, 2006 Apr 13; 55(5). PMID: 16609133    Free PMC article.
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.
Paul A Antony, Chrystal M Paulos, +9 authors, Nicholas P Restifo.
J Immunol, 2006 Apr 20; 176(9). PMID: 16621991    Free PMC article.
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells.
Sergio A Quezada, Karl S Peggs, Michael A Curran, James P Allison.
J Clin Invest, 2006 Jun 17; 116(7). PMID: 16778987    Free PMC article.
Highly Cited.
Regulatory T cells in experimental autoimmune disease.
Elisabeth Suri-Payer, Benedikt Fritzsching.
Springer Semin Immunopathol, 2006 Jul 14; 28(1). PMID: 16838180
The role of virus-induced regulatory T cells in immunopathology.
Shelly J Robertson, Kim J Hasenkrug.
Springer Semin Immunopathol, 2006 Jul 15; 28(1). PMID: 16841143    Free PMC article.
Regulatory T cells, a potent immunoregulatory target for CAM researchers: modulating tumor immunity, autoimmunity and alloreactive immunity (III).
Aristo Vojdani, Jonathan Erde.
Evid Based Complement Alternat Med, 2006 Sep 05; 3(3). PMID: 16951715    Free PMC article.
Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma.
Zhi-Zhang Yang, Anne J Novak, +2 authors, Stephen M Ansell.
Cancer Res, 2006 Oct 19; 66(20). PMID: 17047079    Free PMC article.
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells.
Francesco Marangoni, Sara Trifari, +11 authors, Loïc Dupré.
J Exp Med, 2007 Feb 14; 204(2). PMID: 17296785    Free PMC article.
Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals.
Audrey Kinter, Jonathan McNally, +3 authors, Anthony S Fauci.
Proc Natl Acad Sci U S A, 2007 Mar 16; 104(9). PMID: 17360656    Free PMC article.
Immune surveillance of tumors.
Jeremy B Swann, Mark J Smyth.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476343    Free PMC article.
Highly Cited. Review.
Tregs and rethinking cancer immunotherapy.
Tyler J Curiel.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476346    Free PMC article.
Highly Cited. Review.
A cytokine-mediated link between innate immunity, inflammation, and cancer.
Wan-Wan Lin, Michael Karin.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476347    Free PMC article.
Highly Cited. Review.
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
Silvia Deaglio, Karen M Dwyer, +10 authors, Simon C Robson.
J Exp Med, 2007 May 16; 204(6). PMID: 17502665    Free PMC article.
Highly Cited.
Adoptive T cell therapy for cancer in the clinic.
Carl H June.
J Clin Invest, 2007 Jun 06; 117(6). PMID: 17549249    Free PMC article.
Highly Cited. Review.
Regulatory T cells, transforming growth factor-beta, and immune suppression.
Yisong Y Wan, Richard A Flavell.
Proc Am Thorac Soc, 2007 Jul 04; 4(3). PMID: 17607012    Free PMC article.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.
Mikael J Pittet, Jan Grimm, +6 authors, Ralph Weissleder.
Proc Natl Acad Sci U S A, 2007 Jul 21; 104(30). PMID: 17640914    Free PMC article.
IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes.
Yongqing Li, Cassian Yee.
Blood, 2007 Oct 09; 111(1). PMID: 17921346    Free PMC article.
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.
Joseph F Grosso, Cristin C Kelleher, +10 authors, Charles G Drake.
J Clin Invest, 2007 Oct 13; 117(11). PMID: 17932562    Free PMC article.
Highly Cited.
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.
Filip K Swirski, Cedric R Berger, +4 authors, Ralph Weissleder.
PLoS One, 2007 Oct 25; 2(10). PMID: 17957257    Free PMC article.
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.
Yisong Y Wan, Richard A Flavell.
Immunol Rev, 2007 Nov 06; 220. PMID: 17979848    Free PMC article.
Highly Cited. Review.
Regulatory T cells and tumour immunity - observations in mice and men.
Awen Gallimore, Andrew Godkin.
Immunology, 2007 Dec 11; 123(2). PMID: 18067556    Free PMC article.
Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism.
Michael Esquerré, Baptiste Tauzin, +3 authors, Salvatore Valitutti.
Proc Natl Acad Sci U S A, 2008 Feb 13; 105(7). PMID: 18268354    Free PMC article.
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target.
Dorothy K Sojka, Yu-Hui Huang, Deborah J Fowell.
Immunology, 2008 Mar 19; 124(1). PMID: 18346152    Free PMC article.
Polarized immune responses differentially regulate cancer development.
Magnus Johansson, David G Denardo, Lisa M Coussens.
Immunol Rev, 2008 Mar 28; 222. PMID: 18363999    Free PMC article.
Imaging in the era of molecular oncology.
Ralph Weissleder, Mikael J Pittet.
Nature, 2008 Apr 04; 452(7187). PMID: 18385732    Free PMC article.
Highly Cited. Review.
Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2.
Stefan Fichtner-Feigl, Masaki Terabe, +6 authors, Warren Strober.
Cancer Res, 2008 May 03; 68(9). PMID: 18451175    Free PMC article.
Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17.
Jeong-Seok Nam, Masaki Terabe, +9 authors, Lalage M Wakefield.
Cancer Res, 2008 May 17; 68(10). PMID: 18483277    Free PMC article.
Highly Cited.
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Mei-Ling Chen, Bo-Shiun Yan, +2 authors, Howard L Weiner.
J Immunol, 2008 May 21; 180(11). PMID: 18490732    Free PMC article.
Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.
Karen Sandell Sfanos, Tullia C Bruno, +6 authors, Charles G Drake.
Clin Cancer Res, 2008 Jun 04; 14(11). PMID: 18519750    Free PMC article.
Highly Cited.
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.
Shuang Wei, Andrew B Shreiner, +3 authors, Alfred E Chang.
Cancer Res, 2008 Jul 03; 68(13). PMID: 18593946    Free PMC article.
Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice.
Rosa C Gualano, Michelle J Hansen, +6 authors, Gary P Anderson.
Respir Res, 2008 Jul 17; 9. PMID: 18627612    Free PMC article.
Intravital imaging of CD8+ T cell function in cancer.
Thorsten R Mempel, Christian A Bauer.
Clin Exp Metastasis, 2008 Jul 31; 26(4). PMID: 18665448    Free PMC article.
TGF-beta: a master of all T cell trades.
Ming O Li, Richard A Flavell.
Cell, 2008 Aug 12; 134(3). PMID: 18692464    Free PMC article.
Highly Cited. Review.
Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.
Ailin Bai, Eileen Higham, +2 authors, Jianzhu Chen.
Proc Natl Acad Sci U S A, 2008 Aug 30; 105(35). PMID: 18723683    Free PMC article.
The influence of CD4+ CD25+ Foxp3+ regulatory T cells on the immune response to rotavirus infection.
Bumseok Kim, Ningguo Feng, +4 authors, Harry B Greenberg.
Vaccine, 2008 Aug 30; 26(44). PMID: 18725261    Free PMC article.
TGF-beta and regulatory T cell in immunity and autoimmunity.
Yisong Y Wan, Richard A Flavell.
J Clin Immunol, 2008 Sep 17; 28(6). PMID: 18792765    Free PMC article.
Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells.
David C Gondek, Victor Devries, +4 authors, Randolph J Noelle.
J Immunol, 2008 Sep 20; 181(7). PMID: 18802078    Free PMC article.
Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function.
Ethan M Shevach, Todd S Davidson, +2 authors, John Andersson.
J Clin Immunol, 2008 Sep 24; 28(6). PMID: 18810612
CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer.
Stephan Roux, Lionel Apetoh, +10 authors, François Ghiringhelli.
J Clin Invest, 2008 Oct 03; 118(11). PMID: 18830416    Free PMC article.
Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment.
Seunghee Kim-Schulze, Hong Sung Kim, +2 authors, Howard L Kaufman.
Mol Ther, 2008 Nov 27; 17(2). PMID: 19034262    Free PMC article.
The role of NKT cells in tumor immunity.
Masaki Terabe, Jay A Berzofsky.
Adv Cancer Res, 2008 Dec 06; 101. PMID: 19055947    Free PMC article.
Highly Cited. Review.
In vitro induction of T cells that are resistant to A2 adenosine receptor-mediated immunosuppression.
Akio Ohta, J Kjaergaard, +6 authors, M Sitkovsky.
Br J Pharmacol, 2008 Dec 17; 156(2). PMID: 19076726    Free PMC article.
Prevalence of Foxp3 positive T regulatory cells is increased during progression of cutaneous squamous tumors.
Tae Jung Jang.
Yonsei Med J, 2008 Dec 25; 49(6). PMID: 19108017    Free PMC article.
Behavior of immune players in the tumor microenvironment.
Mikael J Pittet.
Curr Opin Oncol, 2009 Jan 07; 21(1). PMID: 19125019    Free PMC article.
Regulation of immunity at tissue sites of inflammation.
Dorothy K Sojka, Christopher A Lazarski, +3 authors, Deborah J Fowell.
Immunol Res, 2009 Feb 03; 45(2-3). PMID: 19184582
The importance of the age factor in cancer vaccination at older age.
Claudia Gravekamp.
Cancer Immunol Immunother, 2009 Mar 05; 58(12). PMID: 19259666    Free PMC article.
The TGF-beta paradox in human cancer: an update.
Maozhen Tian, William P Schiemann.
Future Oncol, 2009 Mar 17; 5(2). PMID: 19284383    Free PMC article.
The development and function of regulatory T cells.
Creg J Workman, Andrea L Szymczak-Workman, +2 authors, Dario A A Vignali.
Cell Mol Life Sci, 2009 Apr 25; 66(16). PMID: 19390784    Free PMC article.
Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner.
Daniel R Tonkin, Kathryn Haskins.
Eur J Immunol, 2009 May 01; 39(5). PMID: 19404982    Free PMC article.
Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle.
Antoine Leimgruber, Cedric Berger, +11 authors, Mikael J Pittet.
Neoplasia, 2009 May 05; 11(5). PMID: 19412430    Free PMC article.
Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14⁻/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer.
Chien-Ying Liu, Yu-Min Wang, +13 authors, Han-Pin Kuo.
J Cancer Res Clin Oncol, 2009 Jul 03; 136(1). PMID: 19572148
Highly Cited.
Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice.
Guillaume Darrasse-Jèze, Anne-Sophie Bergot, +6 authors, David Klatzmann.
J Clin Invest, 2009 Aug 05; 119(9). PMID: 19652360    Free PMC article.
Regulatory T cells and immune tolerance to tumors.
Xuefang Cao.
Immunol Res, 2009 Sep 19; 46(1-3). PMID: 19763889
Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.
Mei-Ling Chen, Bo-Shiun Yan, Deneen Kozoriz, Howard L Weiner.
Eur J Immunol, 2009 Sep 22; 39(12). PMID: 19768696    Free PMC article.
Engineered interleukin-2 antagonists for the inhibition of regulatory T cells.
David V Liu, Lisa M Maier, David A Hafler, K Dane Wittrup.
J Immunother, 2009 Oct 10; 32(9). PMID: 19816193    Free PMC article.
Blockade of TGF-beta enhances tumor vaccine efficacy mediated by CD8(+) T cells.
Shun Takaku, Masaki Terabe, +4 authors, Jay A Berzofsky.
Int J Cancer, 2009 Oct 16; 126(7). PMID: 19830696    Free PMC article.
Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines.
Ryo Ueda, Mitsugu Fujita, +7 authors, Hideho Okada.
Clin Cancer Res, 2009 Oct 29; 15(21). PMID: 19861464    Free PMC article.
The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade.
Lana E Kandalaft, Nathan Singh, +4 authors, George Coukos.
Gynecol Oncol, 2009 Dec 05; 116(2). PMID: 19959212    Free PMC article.
Transforming growth factor beta (TGF-beta) and inflammation in cancer.
Brian Bierie, Harold L Moses.
Cytokine Growth Factor Rev, 2009 Dec 19; 21(1). PMID: 20018551    Free PMC article.
Highly Cited. Review.
FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.
Anita Schildknecht, Sabine Brauer, +5 authors, Maries van den Broek.
Proc Natl Acad Sci U S A, 2009 Dec 19; 107(1). PMID: 20018763    Free PMC article.
Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity.
Tao Gu, Rachael B Rowswell-Turner, Mehmet O Kilinc, Nejat K Egilmez.
Cancer Res, 2009 Dec 24; 70(1). PMID: 20028855    Free PMC article.
Immune phenotype predicts risk for posttransplantation squamous cell carcinoma.
Robert P Carroll, David San Segundo, +4 authors, Kathryn J Wood.
J Am Soc Nephrol, 2010 Jan 30; 21(4). PMID: 20110382    Free PMC article.
Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance.
J L Mollov, C L Lucas, +3 authors, M Sykes.
Am J Transplant, 2010 Feb 04; 10(3). PMID: 20121730    Free PMC article.
The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth.
Karen A Cavassani, William F Carson, +9 authors, Steven L Kunkel.
Blood, 2010 Feb 05; 115(22). PMID: 20130237    Free PMC article.
CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism.
Jonathan E Fogle, Angela M Mexas, Wayne A Tompkins, Mary B Tompkins.
AIDS Res Hum Retroviruses, 2010 Feb 17; 26(2). PMID: 20156102    Free PMC article.
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Maite Urbieta, Isabel Barao, +5 authors, Robert B Levy.
Blood, 2010 Mar 05; 115(23). PMID: 20200356    Free PMC article.
Regulatory T cells: immune suppression and beyond.
Yisong Y Wan.
Cell Mol Immunol, 2010 Apr 13; 7(3). PMID: 20383175    Free PMC article.
The biologic importance of tumor-infiltrating lymphocytes.
F Stephen Hodi, Glenn Dranoff.
J Cutan Pathol, 2010 May 28; 37 Suppl 1. PMID: 20482675    Free PMC article.
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.
D Lys Guilbride, Pawel Gawlinski, Patrick D L Guilbride.
PLoS One, 2010 May 27; 5(5). PMID: 20502667    Free PMC article.
Plasticity in programming of effector and memory CD8 T-cell formation.
Ramon Arens, Stephen P Schoenberger.
Immunol Rev, 2010 Jun 12; 235(1). PMID: 20536564    Free PMC article.
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.
Li Yang, Yanli Pang, Harold L Moses.
Trends Immunol, 2010 Jun 12; 31(6). PMID: 20538542    Free PMC article.
Highly Cited. Review.
A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer.
Melissa A Geller, Sarah Cooley, +11 authors, Jeffrey S Miller.
Cytotherapy, 2010 Sep 21; 13(1). PMID: 20849361    Free PMC article.
Highly Cited.
Radiation enhances regulatory T cell representation.
Evelyn L Kachikwu, Keisuke S Iwamoto, +5 authors, Dörthe Schaue.
Int J Radiat Oncol Biol Phys, 2010 Nov 26; 81(4). PMID: 21093169    Free PMC article.
Murine melanoma-infiltrating dendritic cells are defective in antigen presenting function regardless of the presence of CD4CD25 regulatory T cells.
Haley Ataera, Evelyn Hyde, +2 authors, Franca Ronchese.
PLoS One, 2011 Mar 11; 6(3). PMID: 21390236    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.
Alice McNally, Geoffrey R Hill, +2 authors, Raymond J Steptoe.
Proc Natl Acad Sci U S A, 2011 Apr 20; 108(18). PMID: 21502514    Free PMC article.
Roles of the immune system in skin cancer.
S Rangwala, K Y Tsai.
Br J Dermatol, 2011 Jul 07; 165(5). PMID: 21729024    Free PMC article.
Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope.
David A Schaer, Yongbiao Li, +8 authors, Jedd D Wolchok.
PLoS One, 2011 Jul 07; 6(6). PMID: 21731676    Free PMC article.
Controversies in clinical cancer dormancy.
Jonathan W Uhr, Klaus Pantel.
Proc Natl Acad Sci U S A, 2011 Jul 13; 108(30). PMID: 21746894    Free PMC article.
Highly Cited. Review.
Requirement of cognate CD4+ T-cell recognition for the regulation of allospecific CTL by human CD4+ CD127- CD25+ FOXP3+ cells generated in MLR.
Yuming Yu, Joshua Miller, +5 authors, James M Mathew.
PLoS One, 2011 Jul 30; 6(7). PMID: 21799858    Free PMC article.
Intestinal inflammation and colorectal cancer: a double-edged sword?
Angelamaria Rizzo, Francesco Pallone, Giovanni Monteleone, Massimo Claudio Fantini.
World J Gastroenterol, 2011 Sep 14; 17(26). PMID: 21912451    Free PMC article.
IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors.
Heba A Alshaker, Khalid Z Matalka.
Cancer Cell Int, 2011 Sep 29; 11. PMID: 21943203    Free PMC article.
Immune recovery after cyclophosphamide treatment in multiple myeloma: implication for maintenance immunotherapy.
Amir Sharabi, Nechama Haran-Ghera.
Bone Marrow Res, 2011 Nov 03; 2011. PMID: 22046558    Free PMC article.
Regulatory T cells and parasites.
T P Velavan, Olusola Ojurongbe.
J Biomed Biotechnol, 2012 Jan 21; 2011. PMID: 22262943    Free PMC article.
Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch.
Chuanwu Wang, Jee H Lee, Chang H Kim.
PLoS One, 2012 Feb 01; 7(1). PMID: 22292042    Free PMC article.
The Role of Regulatory T Cells in Mesothelioma.
Demelza J Ireland, Haydn T Kissick, Manfred W Beilharz.
Cancer Microenviron, 2012 Feb 04; 5(2). PMID: 22302659    Free PMC article.
Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo.
Dafeng Yang, Christina M Torres, +3 authors, Kebin Liu.
J Immunol, 2012 Mar 31; 188(9). PMID: 22461695    Free PMC article.
Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.
Lucile Garidou, Sara Heydari, Selamawit Gossa, Dorian B McGavern.
J Virol, 2012 May 04; 86(13). PMID: 22553324    Free PMC article.
Human CCR4+ CCR6+ Th17 cells suppress autologous CD8+ T cell responses.
Fei Zhao, Bastian Hoechst, +9 authors, Tim F Greten.
J Immunol, 2012 May 23; 188(12). PMID: 22615204    Free PMC article.
Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma.
Miriam Alb, Christopher Sie, +3 authors, David Schrama.
Cancer Immunol Immunother, 2012 Jun 08; 61(12). PMID: 22674057    Free PMC article.
Radiation, inflammation, and immune responses in cancer.
Gabriele Multhoff, Jürgen Radons.
Front Oncol, 2012 Jun 08; 2. PMID: 22675673    Free PMC article.
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
Divya Sekar, Christina Hahn, +2 authors, Andreas Weigert.
Eur J Immunol, 2012 Jun 09; 42(6). PMID: 22678911    Free PMC article.
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.
Shipra Gupta, Thomas B Thornley, +4 authors, Terry B Strom.
J Clin Invest, 2012 Jun 12; 122(7). PMID: 22684103    Free PMC article.
T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy.
Jon G Quatromoni, Yue Wang, +6 authors, James S Economou.
J Transl Med, 2012 Jun 21; 10. PMID: 22713761    Free PMC article.
Regulatory T cells in radiotherapeutic responses.
Dörthe Schaue, Michael W Xie, Josephine A Ratikan, William H McBride.
Front Oncol, 2012 Aug 23; 2. PMID: 22912933    Free PMC article.
Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration.
John Karavitis, Laura M Hix, +3 authors, Ming Zhang.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029485    Free PMC article.
Epitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosis.
Jinjong Myoung, Hyun Seok Kang, +3 authors, Byung S Kim.
J Virol, 2012 Oct 12; 86(24). PMID: 23055563    Free PMC article.
Cellular immune suppressor mechanisms in patients with hepatocellular carcinoma.
Fei Zhao, Firouzeh Korangy, Tim F Greten.
Dig Dis, 2012 Oct 31; 30(5). PMID: 23108303    Free PMC article.
Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice.
Zhi-Yong Xiao, Shao-Hui Chen, +4 authors, Liu-Hong Yun.
Arthritis Res Ther, 2012 Nov 03; 14(6). PMID: 23116248    Free PMC article.
IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.
Erica G Schmitt, Dipica Haribhai, +14 authors, Calvin B Williams.
J Immunol, 2012 Nov 06; 189(12). PMID: 23125413    Free PMC article.
Vaccine injection site matters: qualitative and quantitative defects in CD8 T cells primed as a function of proximity to the tumor in a murine glioma model.
John R Ohlfest, Brian M Andersen, +5 authors, Michael R Olin.
J Immunol, 2012 Dec 19; 190(2). PMID: 23248259    Free PMC article.
Mechanistic links between COPD and lung cancer.
A McGarry Houghton.
Nat Rev Cancer, 2013 Mar 08; 13(4). PMID: 23467302
Highly Cited. Review.
Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection.
Erik L Brincks, Alan D Roberts, +4 authors, David L Woodland.
J Immunol, 2013 Mar 08; 190(7). PMID: 23467933    Free PMC article.
GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Angela X Zhou, Lina Kozhaya, Hodaka Fujii, Derya Unutmaz.
J Immunol, 2013 Apr 12; 190(10). PMID: 23576681    Free PMC article.
Reduced immunosuppressive properties of axitinib in comparison with other tyrosine kinase inhibitors.
Franziska Stehle, Kristin Schulz, +4 authors, Barbara Seliger.
J Biol Chem, 2013 Apr 30; 288(23). PMID: 23625925    Free PMC article.
Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer.
Xiaolin Hu, Kankana Bardhan, +7 authors, Kebin Liu.
J Biol Chem, 2013 May 17; 288(26). PMID: 23677993    Free PMC article.
Impact of early versus late enteral nutrition on cell mediated immunity and its relationship with glucagon like peptide-1 in intensive care unit patients: a prospective study.
Okan Bakiner, Emre Bozkirli, +5 authors, Eda Ertorer.
Crit Care, 2013 Jun 22; 17(3). PMID: 23786864    Free PMC article.
Cancer vaccines: Looking to the future.
Kavitha Yaddanapudi, Robert A Mitchell, John W Eaton.
Oncoimmunology, 2013 Jun 27; 2(3). PMID: 23802081    Free PMC article.
Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis.
Fernanda O Novais, Lucas P Carvalho, +8 authors, Phillip Scott.
PLoS Pathog, 2013 Jul 23; 9(7). PMID: 23874205    Free PMC article.
Lentivirus-activated T regulatory cells suppress T helper cell interleukin-2 production by inhibiting nuclear factor of activated T cells 2 binding to the interleukin-2 promoter.
Liping Meng, Mary Tompkins, Michelle Miller, Jonathan Fogle.
AIDS Res Hum Retroviruses, 2013 Aug 09; 30(1). PMID: 23924068    Free PMC article.
Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer.
Alessia Burocchi, Mario P Colombo, Silvia Piconese.
Front Immunol, 2013 Aug 30; 4. PMID: 23986759    Free PMC article.
Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance.
C Bryant, H Suen, +11 authors, D E Joshua.
Blood Cancer J, 2013 Sep 17; 3. PMID: 24036947    Free PMC article.
Combination therapy with a second-generation androgen receptor antagonist and a metastasis vaccine improves survival in a spontaneous prostate cancer model.
Andressa Ardiani, Benedetto Farsaci, +5 authors, James W Hodge.
Clin Cancer Res, 2013 Sep 21; 19(22). PMID: 24048332    Free PMC article.
Tumor secretion of CCL22 activates intratumoral Treg infiltration and is independent prognostic predictor of breast cancer.
Ya-Qing Li, Fang-Fang Liu, +3 authors, Li Fu.
PLoS One, 2013 Oct 15; 8(10). PMID: 24124553    Free PMC article.
Chimeric antigen receptor therapy for cancer.
David M Barrett, Nathan Singh, +2 authors, Carl H June.
Annu Rev Med, 2013 Nov 28; 65. PMID: 24274181    Free PMC article.
Highly Cited. Review.
Critical stoichiometric ratio of CD4(+)  CD25(+)  FoxP3(+) regulatory T cells and CD4(+)  CD25(-) responder T cells influence immunosuppression in patients with B-cell acute lymphoblastic leukaemia.
Kaushik Bhattacharya, Sarmila Chandra, Chitra Mandal.
Immunology, 2013 Dec 21; 142(1). PMID: 24354800    Free PMC article.
Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression.
Amy V Paschall, Mary A Zimmerman, +8 authors, Kebin Liu.
BMC Cancer, 2014 Jan 16; 14. PMID: 24422988    Free PMC article.
Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+ T-cell effector differentiation by IL-2 modulation.
Alice McNally, Michael McNally, +2 authors, Raymond J Steptoe.
PLoS One, 2014 Jan 24; 9(1). PMID: 24454872    Free PMC article.
TGF-β1 precursor and CD8 are potential prognostic and predictive markers in operated breast cancer.
Hai-Ming Yu, Jun-Lan Yang, +2 authors, Ying Li.
J Huazhong Univ Sci Technolog Med Sci, 2014 Feb 06; 34(1). PMID: 24496679
Immunocompetent murine models for the study of glioblastoma immunotherapy.
Taemin Oh, Shayan Fakurnejad, +7 authors, Andrew T Parsa.
J Transl Med, 2014 May 02; 12. PMID: 24779345    Free PMC article.
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
Christian A Bauer, Edward Y Kim, +3 authors, Thorsten R Mempel.
J Clin Invest, 2014 May 09; 124(6). PMID: 24812664    Free PMC article.
Highly Cited.
Two faces of TGF-beta1 in breast cancer.
Joanna Magdalena Zarzynska.
Mediators Inflamm, 2014 Jun 04; 2014. PMID: 24891760    Free PMC article.
Highly Cited. Review.
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.
Andreas Herrmann, Saul J Priceman, +10 authors, Hua Yu.
J Clin Invest, 2014 Jun 04; 124(7). PMID: 24892807    Free PMC article.
FOXP3+ lymphocyte density in pancreatic cancer correlates with lymph node metastasis.
Yongjian Jiang, Zunguo Du, +5 authors, Deliang Fu.
PLoS One, 2014 Sep 06; 9(9). PMID: 25191901    Free PMC article.
In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells.
Aline Alves de Lima Silva, Paulo Ricardo Criado, +5 authors, Carla Pagliari.
PLoS Negl Trop Dis, 2014 Sep 19; 8(9). PMID: 25233082    Free PMC article.
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Tom L Stephen, Melanie R Rutkowski, +8 authors, Jose R Conejo-Garcia.
Immunity, 2014 Sep 23; 41(3). PMID: 25238097    Free PMC article.
Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy.
Dayna R Clark, Vandana Chaturvedi, +4 authors, Sing Sing Way.
Cell Mol Immunol, 2014 Sep 23; 11(6). PMID: 25242275    Free PMC article.
Microenvironment of tumor-draining lymph nodes: opportunities for liposome-based targeted therapy.
Siddarth Chandrasekaran, Michael R King.
Int J Mol Sci, 2014 Nov 08; 15(11). PMID: 25380524    Free PMC article.
Victory and defeat in the induction of a therapeutic response through vaccine therapy for human and canine brain tumors: a review of the state of the art.
Michael R Olin, G Elizabeth Pluhar, +3 authors, Christopher L Moertel.
Crit Rev Immunol, 2014 Nov 19; 34(5). PMID: 25404047    Free PMC article.
NK cell-based immunotherapies in Pediatric Oncology.
Kimberly A McDowell, Jacquelyn A Hank, +3 authors, Paul M Sondel.
J Pediatr Hematol Oncol, 2015 Jan 16; 37(2). PMID: 25590232    Free PMC article.
Asthma and risk of lethal prostate cancer in the Health Professionals Follow-Up Study.
Elizabeth A Platz, Charles G Drake, +7 authors, Edward Giovannucci.
Int J Cancer, 2015 Feb 05; 137(4). PMID: 25648070    Free PMC article.
Liposome-encapsulated CpG enhances antitumor activity accompanying the changing of lymphocyte populations in tumor via intratumoral administration.
Dong Hyeok Kim, Chaerin Moon, +6 authors, Kwang Dong Kim.
Nucleic Acid Ther, 2015 Feb 19; 25(2). PMID: 25692533    Free PMC article.
Antibody response to BK polyomavirus as a prognostic biomarker and potential therapeutic target in prostate cancer.
Xavier Etienne Keller, Piotr Kardas, +8 authors, Maurizio Provenzano.
Oncotarget, 2015 Mar 10; 6(8). PMID: 25749042    Free PMC article.
Differential regulation and function of tumor-infiltrating T cells in different stages of breast cancer patients.
Shiguang Zhu, Jun Lin, +2 authors, Haidong Zou.
Tumour Biol, 2015 May 09; 36(10). PMID: 25953262
Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients.
Yong Shen, Suzhan Zhang, +2 authors, Jing Qian.
Emerg Microbes Infect, 2015 Jun 04; 4(3). PMID: 26038769    Free PMC article.
TGF-β signaling and its targeting for glioma treatment.
Jianfeng Han, Christopher A Alvarez-Breckenridge, Qi-En Wang, Jianhua Yu.
Am J Cancer Res, 2015 Jun 06; 5(3). PMID: 26045979    Free PMC article.
Highly Cited. Review.
Challenges and future perspectives of T cell immunotherapy in cancer.
Maria Teresa P de Aquino, Anshu Malhotra, Manoj K Mishra, Anil Shanker.
Immunol Lett, 2015 Jun 23; 166(2). PMID: 26096822    Free PMC article.
Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich's Ascites Tumor in Mice.
Saurabh Singh, Sanjay Pandey, +7 authors, Bilikere S Dwarakanath.
PLoS One, 2015 Jul 03; 10(7). PMID: 26135741    Free PMC article.
H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.
Amy V Paschall, Dafeng Yang, +9 authors, Kebin Liu.
J Immunol, 2015 Jul 03; 195(4). PMID: 26136424    Free PMC article.
Cancer and the Immune System: Basic Concepts and Targets for Intervention.
Drew Pardoll.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320058    Free PMC article.
Highly Cited. Review.
CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity.
G Elizabeth Pluhar, Christopher A Pennell, Michael R Olin.
Crit Rev Immunol, 2015 Sep 10; 35(2). PMID: 26351148    Free PMC article.
Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine.
Tien-Jen Lin, Wen-Miin Liang, +5 authors, Ning-Sun Yang.
PLoS One, 2015 Oct 02; 10(10). PMID: 26426423    Free PMC article.
In vivo induction of regulatory T cells for immune tolerance in hemophilia.
Xiaomei Wang, Cox Terhorst, Roland W Herzog.
Cell Immunol, 2015 Oct 12; 301. PMID: 26454643    Free PMC article.
Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.
Takumi Kumai, Takayuki Ohkuri, +7 authors, Hiroya Kobayashi.
Sci Rep, 2015 Nov 06; 5. PMID: 26538233    Free PMC article.
Immune Adjuvant Activity of Pre-Resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer.
Fumito Ito, Amy W Ku, +9 authors, Sharon S Evans.
PLoS One, 2015 Nov 26; 10(11). PMID: 26599402    Free PMC article.
Suppression of the noninvolved pair of the myeloma isotype correlates with poor survival in newly diagnosed and relapsed/refractory patients with myeloma.
Heinz Ludwig, Dejan Milosavljevic, +4 authors, Stephen Harding.
Am J Hematol, 2015 Dec 15; 91(3). PMID: 26662888    Free PMC article.
Expression and significance of CD4(+)CD25(+)CD127(-) regulatory T cells in peripheral blood of patients with different phenotypes of Guillain-Barré syndrome.
Hao Wang, Li Li, +3 authors, Wei-Dong Qian.
Int J Clin Exp Med, 2016 Jan 16; 8(10). PMID: 26770543    Free PMC article.
Effects of radiation on T regulatory cells in normal states and cancer: mechanisms and clinical implications.
Shu Liu, Xiangdong Sun, +5 authors, Xinchen Sun.
Am J Cancer Res, 2016 Jan 26; 5(11). PMID: 26807310    Free PMC article.
Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys.
Dan H Barouch, Khader Ghneim, +23 authors, Rafick-Pierre Sekaly.
Cell, 2016 Apr 18; 165(3). PMID: 27085913    Free PMC article.
Highly Cited.
GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.
Liping Sun, Hao Jin, Hui Li.
Oncotarget, 2016 Apr 21; 7(27). PMID: 27095576    Free PMC article.
Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus.
Leilei Zhou, Tianyi Cao, +5 authors, Guoyao Tang.
Inflammation, 2016 Apr 24; 39(3). PMID: 27106476
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
Hristina Nedelkovska, Alexander F Rosenberg, +9 authors, Steven H Bernstein.
PLoS One, 2016 May 27; 11(5). PMID: 27228053    Free PMC article.
Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune Response.
John Reiser, Arnob Banerjee.
J Immunol Res, 2016 Jun 18; 2016. PMID: 27314056    Free PMC article.
Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists.
Soraya Zorro Manrique, Ana L Dominguez, +7 authors, Peter A Cohen.
Oncotarget, 2016 Jun 25; 7(28). PMID: 27341020    Free PMC article.
INFα-2b inhibitory effects on CD4(+)CD25(+)FOXP3(+) regulatory T cells in the tumor microenvironment of C57BL/6 J mice with melanoma xenografts.
Yang Yu, Run Huang, +2 authors, Wenju Mo.
BMC Cancer, 2016 Jul 09; 16. PMID: 27389040    Free PMC article.
Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes.
Genevieve L Coe, Priscilla S Redd, +6 authors, Kebin Liu.
Sci Rep, 2016 Aug 05; 6. PMID: 27487939    Free PMC article.
Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity.
Kristian M Hargadon.
J Clin Med, 2016 Sep 03; 5(9). PMID: 27589814    Free PMC article.
TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis.
Xinru Zhou, Yong Mao, +12 authors, Xueguang Zhang.
Oncotarget, 2016 Sep 15; 7(41). PMID: 27626488    Free PMC article.
Boosting Tumor-Specific Immunity Using PDT.
Nicole Maeding, Thomas Verwanger, Barbara Krammer.
Cancers (Basel), 2016 Oct 27; 8(10). PMID: 27782066    Free PMC article.
Rescue of Tolerant CD8+ T Cells during Cancer Immunotherapy with IL2:Antibody Complexes.
Lauryn E Klevorn, Melissa M Berrien-Elliott, +4 authors, Ryan M Teague.
Cancer Immunol Res, 2016 Nov 03; 4(12). PMID: 27803062    Free PMC article.
Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy.
Shuhong Qi, Hui Li, +7 authors, Zhihong Zhang.
Elife, 2016 Nov 20; 5. PMID: 27855783    Free PMC article.
Role of immune cells in pancreatic cancer from bench to clinical application: An updated review.
Jae Hyuck Chang, Yongjian Jiang, Venu G Pillarisetty.
Medicine (Baltimore), 2016 Dec 09; 95(49). PMID: 27930550    Free PMC article.
Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4+CD25+ Regulatory T Cells.
Da-Wei Wang, Ning Dong, +3 authors, Yong-Ming Yao.
Sci Rep, 2016 Dec 13; 6. PMID: 27941849    Free PMC article.
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Limo Chen, Xiaohui Yi, +13 authors, Don L Gibbons.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999749    Free PMC article.
A polyethylenimine-modified carboxyl-poly(styrene/acrylamide) copolymer nanosphere for co-delivering of CpG and TGF-β receptor I inhibitor with remarkable additive tumor regression effect against liver cancer in mice.
Shuyan Liang, Jun Hu, +3 authors, Xiangliang Yang.
Int J Nanomedicine, 2016 Dec 23; 11. PMID: 28008250    Free PMC article.
Determinants of metastatic competency in colorectal cancer.
Daniele V F Tauriello, Alexandre Calon, Enza Lonardo, Eduard Batlle.
Mol Oncol, 2017 Jan 14; 11(1). PMID: 28085225    Free PMC article.
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.
Tom L Stephen, Kyle K Payne, +11 authors, Jose R Conejo-Garcia.
Immunity, 2017 Jan 19; 46(1). PMID: 28099864    Free PMC article.
Highly Cited.
The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.
Chunwan Lu, Amy V Paschall, +6 authors, Kebin Liu.
J Natl Cancer Inst, 2017 Jan 31; 109(6). PMID: 28131992    Free PMC article.
Highly Cited.
TGF-β Family Signaling in Tumor Suppression and Cancer Progression.
Joan Seoane, Roger R Gomis.
Cold Spring Harb Perspect Biol, 2017 Mar 02; 9(12). PMID: 28246180    Free PMC article.
Highly Cited. Review.
Characterization of immune cells and infection by HIV in human ovarian tissues.
Zheng Shen, Marta Rodriguez-Garcia, Christina Ochsenbauer, Charles R Wira.
Am J Reprod Immunol, 2017 Apr 12; 78(1). PMID: 28397318    Free PMC article.
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Kyun-Do Kim, Seyeon Bae, +8 authors, Minsoo Kim.
Nat Commun, 2017 May 16; 8. PMID: 28504276    Free PMC article.
Japanese Kampo medicine ninjin'yoeito synergistically enhances tumor vaccine effects mediated by CD8+ T cells.
Shun Takaku, Masumi Shimizu, Hidemi Takahashi.
Oncol Lett, 2017 May 23; 13(5). PMID: 28529575    Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism.
Jianxiang Chen, Yiting Qiao, +10 authors, Zi-Chun Hua.
Theranostics, 2017 Jul 26; 7(8). PMID: 28740548    Free PMC article.
Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy.
Rajeev Shrimali, Shamim Ahmad, +7 authors, Samir N Khleif.
J Immunother Cancer, 2017 Aug 16; 5(1). PMID: 28807056    Free PMC article.
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment.
Sadna Budhu, David A Schaer, +8 authors, Jedd D Wolchok.
Sci Signal, 2017 Aug 31; 10(494). PMID: 28851824    Free PMC article.
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
Amy E Baek, Yen-Rei A Yu, +12 authors, Erik R Nelson.
Nat Commun, 2017 Oct 13; 8(1). PMID: 29021522    Free PMC article.
Highly Cited.
The immune system in cancer metastasis: friend or foe?
Louise M E Janssen, Emma E Ramsay, Craig D Logsdon, Willem W Overwijk.
J Immunother Cancer, 2017 Oct 19; 5(1). PMID: 29037250    Free PMC article.
Highly Cited. Review.
Comparative Network Analysis of Patients with Non-Small Cell Lung Cancer and Smokers for Representing Potential Therapeutic Targets.
Mehrdad Pazhouhandeh, Fatemeh Samiee, +12 authors, Fatemeh Rahimi Jamnani.
Sci Rep, 2017 Oct 25; 7(1). PMID: 29062084    Free PMC article.
Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.
Jessica Roelands, Peter J K Kuppen, +6 authors, Wouter Hendrickx.
Int J Mol Sci, 2017 Oct 25; 18(10). PMID: 29064420    Free PMC article.
Lambda phage nanoparticles displaying HER2-derived E75 peptide induce effective E75-CD8+ T response.
Atefeh Arab, Jessica Nicastro, +8 authors, Javad Behravan.
Immunol Res, 2017 Nov 17; 66(1). PMID: 29143917
Advances in immunotherapeutic research for glioma therapy.
Jeremy Tetsuo Miyauchi, Stella E Tsirka.
J Neurol, 2017 Dec 07; 265(4). PMID: 29209782    Free PMC article.
Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model.
Hayley C Warsinske, Elsje Pienaar, +2 authors, Denise E Kirschner.
Front Immunol, 2018 Jan 13; 8. PMID: 29326718    Free PMC article.
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
Rajani Ravi, Kimberly A Noonan, +13 authors, Atul Bedi.
Nat Commun, 2018 Feb 23; 9(1). PMID: 29467463    Free PMC article.
Highly Cited.
The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach.
Daniëlle Krijgsman, Marianne Hokland, Peter J K Kuppen.
Front Immunol, 2018 Mar 15; 9. PMID: 29535734    Free PMC article.
Comparison of T Helper Cell Patterns in Primary Open-Angle Glaucoma and Normal-Pressure Glaucoma.
Chunyu Guo, Ningbo Wu, +3 authors, Wenyi Guo.
Med Sci Monit, 2018 Apr 05; 24. PMID: 29616680    Free PMC article.
TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.
Laia Caja, Francesco Dituri, +4 authors, Isabel Fabregat.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701666    Free PMC article.
Highly Cited. Review.
Integrative Pharmacology: Advancing Development of Effective Immunotherapies.
Mohammad Tabrizi, Daping Zhang, Vaishnavi Ganti, Glareh Azadi.
AAPS J, 2018 Apr 29; 20(4). PMID: 29704129
Challenges and prospects of chimeric antigen receptor T cell therapy in solid tumors.
Vishal Jindal, Ena Arora, Sorab Gupta.
Med Oncol, 2018 May 08; 35(6). PMID: 29730801
TGF-β-responsive CAR-T cells promote anti-tumor immune function.
Andrew J Hou, ZeNan L Chang, +2 authors, Yvonne Y Chen.
Bioeng Transl Med, 2018 Aug 02; 3(2). PMID: 30065964    Free PMC article.
Radiation, inflammation and the immune response in cancer.
Kelly J McKelvey, Amanda L Hudson, +2 authors, Connie I Diakos.
Mamm Genome, 2018 Sep 05; 29(11-12). PMID: 30178305    Free PMC article.
Exploring immuno-regulatory mechanisms in the tumor microenvironment: Model and design of protocols for cancer remission.
Piyali Ganguli, Ram Rup Sarkar.
PLoS One, 2018 Sep 06; 13(9). PMID: 30183728    Free PMC article.
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Cintia L Araujo Furlan, Jimena Tosello Boari, +9 authors, Eva V Acosta Rodriguez.
Front Immunol, 2018 Nov 21; 9. PMID: 30455700    Free PMC article.
Oncolytic virus immunotherapy: future prospects for oncology.
Junaid Raja, Johannes M Ludwig, +2 authors, Hyun S Kim.
J Immunother Cancer, 2018 Dec 06; 6(1). PMID: 30514385    Free PMC article.
Immunophenotypes of pancreatic ductal adenocarcinoma: Meta-analysis of transcriptional subtypes.
Ines de Santiago, Christopher Yau, +5 authors, Shivan Sivakumar.
Int J Cancer, 2019 Feb 06; 145(4). PMID: 30720864    Free PMC article.
Targeting immunotherapy for bladder cancer by using anti-CD3 × CD155 bispecific antibody.
Wanru Ma, Juan Ma, +2 authors, Man Zhang.
J Cancer, 2019 Oct 12; 10(21). PMID: 31602268    Free PMC article.
Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms.
Ibrahim Halil Sahin, Mehmet Akce, +4 authors, Christina Wu.
Br J Cancer, 2019 Oct 15; 121(10). PMID: 31607751    Free PMC article.
Application Of Adoptive Immunotherapy In Ovarian Cancer.
Siyu Yang, Xiaojiao Yin, Ying Yue, Siqing Wang.
Onco Targets Ther, 2019 Oct 22; 12. PMID: 31632055    Free PMC article.
Ping-Pong-Tumor and Host in Pancreatic Cancer Progression.
Wei Mu, Zhe Wang, Margot Zöller.
Front Oncol, 2020 Jan 11; 9. PMID: 31921628    Free PMC article.
Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+ CD25+ regulatory T cells.
Yun Ge, Man Huang, +2 authors, Yong-Ming Yao.
J Cell Mol Med, 2019 Dec 28; 24(2). PMID: 31880383    Free PMC article.
Neutrophil Suppresses Tumor Cell Proliferation via Fas /Fas Ligand Pathway Mediated Cell Cycle Arrested.
Bingwei Sun, Weiting Qin, +4 authors, Hui Sun.
Int J Biol Sci, 2018 Dec 27; 14(14). PMID: 30585273    Free PMC article.
Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model.
Yangjin Kim, Donggu Lee, +2 authors, Sean Lawler.
PLoS One, 2019 Jan 29; 14(1). PMID: 30689655    Free PMC article.
Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response.
Thorsten R Mempel, Francesco Marangoni.
Immunol Rev, 2019 Apr 13; 289(1). PMID: 30977195    Free PMC article.
Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25-Foxp3+ T cells.
Magdalena J Polanczyk, Edwin Walker, +2 authors, Emmanuel T Akporiaye.
J Transl Med, 2019 Jul 11; 17(1). PMID: 31288845    Free PMC article.
Immunogenicity of Protein Pharmaceuticals.
Robert Dingman, Sathy V Balu-Iyer.
J Pharm Sci, 2019 Jan 02; 108(5). PMID: 30599169    Free PMC article.
Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer.
Glauben Landskron, Marjorie De la Fuente López, +18 authors, Marcela A Hermoso.
Front Immunol, 2019 Jul 10; 10. PMID: 31281317    Free PMC article.
Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer.
Dan J M Nguyen, George Theodoropoulos, +6 authors, Medhi Wangpaichitr.
Mol Cancer Res, 2019 Oct 20; 18(1). PMID: 31628200    Free PMC article.
IRF4 instructs effector Treg differentiation and immune suppression in human cancer.
Giorgia Alvisi, Jolanda Brummelman, +18 authors, Enrico Lugli.
J Clin Invest, 2020 Mar 04; 130(6). PMID: 32125291    Free PMC article.
The role of transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas.
Alexander A Strait, Xiao-Jing Wang.
Mol Carcinog, 2020 Apr 18; 59(7). PMID: 32301180    Free PMC article.
Transforming growth factor β (TGF-β) receptor signaling regulates kinase networks and phosphatidylinositol metabolism during T-cell activation.
Richard T Cattley, Mijoon Lee, William C Boggess, William F Hawse.
J Biol Chem, 2020 May 03; 295(24). PMID: 32358062    Free PMC article.
Recombinant Costimulatory Fusion Proteins as Functional Immunomodulators Enhance Antitumor Activity in Murine B16F10 Melanoma.
Huaman Cai, Wenfang Wang, +4 authors, Rongxiu Li.
Vaccines (Basel), 2020 May 20; 8(2). PMID: 32423130    Free PMC article.
Galunisertib enhances chimeric antigen receptor-modified T cell function.
Zhixiong Wang, Qian Liu, +7 authors, Xuekai Zhu.
Eur J Histochem, 2020 Jul 25; 64(s2). PMID: 32705856    Free PMC article.
Frontal Fibrosing Alopecia. An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?
Rowland Noakes.
Clin Cosmet Investig Dermatol, 2020 Aug 18; 13. PMID: 32801823    Free PMC article.
Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning.
Jonathan G Pol, Matthew J Atherton, +7 authors, Brian D Lichty.
J Immunother Cancer, 2020 Aug 15; 8(2). PMID: 32792361    Free PMC article.
Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies.
Shin Foong Ngiow, Arabella Young.
Front Immunol, 2020 Aug 28; 11. PMID: 32849557    Free PMC article.
Use of Cell and Genome Modification Technologies to Generate Improved "Off-the-Shelf" CAR T and CAR NK Cells.
Michael A Morgan, Hildegard Büning, Martin Sauer, Axel Schambach.
Front Immunol, 2020 Sep 10; 11. PMID: 32903482    Free PMC article.
Contributions of immune cell populations in the maintenance, progression, and therapeutic modalities of glioma.
Michael D Caponegro, Jeremy Tetsuo Miyauchi, Stella E Tsirka.
AIMS Allergy Immunol, 2018 Jan 01; 2(1). PMID: 32914058    Free PMC article.
Transforming Growth Factor-β Signaling in Immunity and Cancer.
Eduard Batlle, Joan Massagué.
Immunity, 2019 Apr 18; 50(4). PMID: 30995507    Free PMC article.
Highly Cited. Review.
Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.
Maxim Shevtsov, Hiro Sato, Gabriele Multhoff, Atsushi Shibata.
Front Oncol, 2019 Apr 04; 9. PMID: 30941308    Free PMC article.
Turning the Tide Against Regulatory T Cells.
SeongJun Han, Aras Toker, Zhe Qi Liu, Pamela S Ohashi.
Front Oncol, 2019 May 07; 9. PMID: 31058083    Free PMC article.
Evaluation of rs1982073 polymorphism of transforming growth factor-β1 in glioblastoma.
Yasaman Sadeghi, Pouya Tabatabaei Irani, +3 authors, Shaghayegh Haghjooy Javanmard.
J Res Med Sci, 2019 Jun 05; 24. PMID: 31160907    Free PMC article.
Evaluation of selected mechanisms of immune tolerance in psoriasis.
Agnieszka Owczarczyk-Saczonek, Joanna Czerwińska, Małgorzata Orylska, Waldemar Placek.
Postepy Dermatol Alergol, 2019 Jul 25; 36(3). PMID: 31333349    Free PMC article.
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front.
Christian M Schürch, Salil S Bhate, +11 authors, Garry P Nolan.
Cell, 2020 Aug 09; 182(5). PMID: 32763154    Free PMC article.
Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy.
Simone Nüssing, Joseph A Trapani, Ian A Parish.
Front Immunol, 2020 Oct 20; 11. PMID: 33072137    Free PMC article.
Solanine Inhibits Immune Escape Mediated by Hepatoma Treg Cells via the TGFβ/Smad Signaling Pathway.
Juwei Gao, Yinyin Ying, Jue Wang, Yiyi Cui.
Biomed Res Int, 2020 Nov 19; 2020. PMID: 33204731    Free PMC article.
Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity.
Vivian Weiwen Xue, Jeff Yat-Fai Chung, +7 authors, Patrick Ming-Kuen Tang.
Cancers (Basel), 2020 Oct 30; 12(11). PMID: 33114183    Free PMC article.
Targeting TGF-β Signaling for Therapeutic Gain.
Rosemary J Akhurst.
Cold Spring Harb Perspect Biol, 2017 Mar 02; 9(10). PMID: 28246179    Free PMC article.
Highly Cited. Review.
Integrative diagnosis of cancer by combining CTCs and associated peripheral blood cells in liquid biopsy.
W-W Zhang, Y Rong, +3 authors, F-B Wang.
Clin Transl Oncol, 2018 Dec 21; 21(7). PMID: 30569214
Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer.
Lisa König, Fabian D Mairinger, +5 authors, Agnes Bankfalvi.
BMC Cancer, 2019 Feb 06; 19(1). PMID: 30717704    Free PMC article.
Statins affect human glioblastoma and other cancers through TGF-β inhibition.
Aizhen Xiao, Breanna Brenneman, +10 authors, Benjamin Purow.
Oncotarget, 2019 Mar 23; 10(18). PMID: 30899443    Free PMC article.
The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer.
Eva Pastille, Marie-Hélène Wasmer, +14 authors, Philippe Krebs.
Mucosal Immunol, 2019 Jun 06; 12(4). PMID: 31165767    Free PMC article.
Highly Cited.
TGFβ biology in cancer progression and immunotherapy.
Rik Derynck, Shannon J Turley, Rosemary J Akhurst.
Nat Rev Clin Oncol, 2020 Jul 28; 18(1). PMID: 32710082
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis.
James C Lee, Sadaf Mehdizadeh, +5 authors, Jeffrey A Bluestone.
Sci Immunol, 2020 Oct 04; 5(52). PMID: 33008914    Free PMC article.
Role of hydrogen sulfide donors in cancer development and progression.
Ebenezeri Erasto Ngowi, Attia Afzal, +9 authors, Dong-Dong Wu.
Int J Biol Sci, 2021 Jan 05; 17(1). PMID: 33390834    Free PMC article.
Targeting transforming growth factor-β signaling for enhanced cancer chemotherapy.
Jitang Chen, Ze-Yang Ding, +6 authors, Xiangliang Yang.
Theranostics, 2021 Jan 05; 11(3). PMID: 33391538    Free PMC article.
Immunostimulatory biomaterials to boost tumor immunogenicity.
Oluwaseyi T Shofolawe-Bakare, Larry D Stokes, +2 authors, Thomas A Werfel.
Biomater Sci, 2020 Oct 14; 8(20). PMID: 33049007    Free PMC article.
TGF-β in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment.
Roberta Angioni, Ricardo Sánchez-Rodríguez, Antonella Viola, Barbara Molon.
Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33499083    Free PMC article.
Identification of a prognostic and therapeutic immune signature associated with hepatocellular carcinoma.
Yanan Peng, Chang Liu, +7 authors, Qiu Zhao.
Cancer Cell Int, 2021 Feb 12; 21(1). PMID: 33568167    Free PMC article.
Adoptive Transfer of Regulatory Immune Cells in Organ Transplantation.
Nathaniel Oberholtzer, Carl Atkinson, Satish N Nadig.
Front Immunol, 2021 Mar 20; 12. PMID: 33737934    Free PMC article.
Critical Roles of Balanced T Helper 9 Cells and Regulatory T Cells in Allergic Airway Inflammation and Tumor Immunity.
Muhua Huang, Jingcheng Dong.
J Immunol Res, 2021 Mar 23; 2021. PMID: 33748292    Free PMC article.
Perspective on the treatment of non-small cell lung cancer in the context of potential SARS-CoV-2 infection during the pandemic.
George Theodoropoulos, Katerina Albanis, Medhi Wangpaichitr.
J Curr Sci Technol, 2021 Apr 02; 11(1). PMID: 33791600    Free PMC article.
Novel therapies emerging in oncology to target the TGF-β pathway.
Byung-Gyu Kim, Ehsan Malek, +2 authors, James J Driscoll.
J Hematol Oncol, 2021 Apr 08; 14(1). PMID: 33823905    Free PMC article.
Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth.
Lauren M Kreps, Christina L Addison.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33805598    Free PMC article.
Ruthenium (II)/allopurinol complex inhibits breast cancer progression via multiple targets.
Ingrid O Travassos, Francyelli Mello-Andrade, +7 authors, Elisângela P de Silveira-Lacerda.
J Biol Inorg Chem, 2021 Apr 11; 26(4). PMID: 33837856
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas.
Zohreh Amoozgar, Jonas Kloepper, +19 authors, Rakesh K Jain.
Nat Commun, 2021 May 13; 12(1). PMID: 33976133    Free PMC article.
Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity.
Ji-Hee Nam, Jun-Ho Lee, +4 authors, Dae-Seog Lim.
Int J Mol Sci, 2021 May 01; 22(9). PMID: 33922658    Free PMC article.
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy.
Amrita Basu, Ganesan Ramamoorthi, +7 authors, Krithika Kodumudi.
Front Immunol, 2021 May 21; 12. PMID: 34012451    Free PMC article.
Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies.
Maria B Garcia-Fabiani, Santiago Haase, +15 authors, Maria G Castro.
Front Oncol, 2021 Jun 26; 11. PMID: 34168976    Free PMC article.
Neoantigens elicit T cell responses in breast cancer.
Takafumi Morisaki, Makoto Kubo, +10 authors, Masafumi Nakamura.
Sci Rep, 2021 Jul 02; 11(1). PMID: 34193879    Free PMC article.
The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells.
Takashi MaruYama, Shuhei Kobayashi, +12 authors, Hiroyuki Shibata.
Front Immunol, 2021 Jul 13; 12. PMID: 34248973    Free PMC article.
TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment.
Jeff Yat-Fai Chung, Max Kam-Kwan Chan, +6 authors, Patrick Ming-Kuen Tang.
Int J Mol Sci, 2021 Jul 25; 22(14). PMID: 34299192    Free PMC article.
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer.
Abu Osman, Bingyu Yan, +7 authors, Khashayarsha Khazaie.
Nat Immunol, 2021 Aug 14; 22(9). PMID: 34385712    Free PMC article.
The Multifaceted Role of TGF-β in Gastrointestinal Tumors.
Fabio Sabbadini, Monica Bertolini, +4 authors, Davide Melisi.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439114    Free PMC article.
Increased CD3+, CD8+, or FoxP3+ T Lymphocyte Infiltrations Are Associated with the Pathogenesis of Colorectal Cancer but Not with the Overall Survival of Patients.
Ana Margarida Barbosa, Olga Martinho, +7 authors, Egídio Torrado.
Biology (Basel), 2021 Aug 28; 10(8). PMID: 34440038    Free PMC article.
TGF-β/IL-7 Chimeric Switch Receptor-Expressing CAR-T Cells Inhibit Recurrence of CD19-Positive B Cell Lymphoma.
Kyung-Eun Noh, Jun-Ho Lee, +8 authors, Dae-Seog Lim.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445415    Free PMC article.
Combination strategies to maximize the benefits of cancer immunotherapy.
Shaoming Zhu, Tian Zhang, +5 authors, Chong-Xian Pan.
J Hematol Oncol, 2021 Sep 29; 14(1). PMID: 34579759    Free PMC article.
Microenvironmental modulation of the developing tumour: an immune-stromal dialogue.
James O Jones, William M Moody, Jacqueline D Shields.
Mol Oncol, 2020 Aug 03; 15(10). PMID: 32741067    Free PMC article.
Targeting immunosuppression by TGF-β1 for cancer immunotherapy.
Grégoire de Streel, Sophie Lucas.
Biochem Pharmacol, 2021 Jul 25; 192. PMID: 34302795    Free PMC article.
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8+ T cells in lymphoid tissue.
Sheikh Abdul Rahman, Bhrugu Yagnik, +6 authors, Rama Rao Amara.
Sci Immunol, 2021 Sep 14; 6(63). PMID: 34516743    Free PMC article.
Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer.
Shaoming Zhu, A-Hong Ma, +12 authors, Chong-Xian Pan.
J Immunother Cancer, 2021 Nov 03; 9(11). PMID: 34725212    Free PMC article.
Direct and Indirect Effect of TGFβ on Treg Transendothelial Recruitment in HCC Tissue Microenvironment.
Francesco Dituri, Serena Mancarella, +5 authors, Gianluigi Giannelli.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34769191    Free PMC article.
CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro.
Khadijeh Alishah, Matthias Birtel, +6 authors, Sedighe Asad.
J Transl Med, 2021 Nov 29; 19(1). PMID: 34838059    Free PMC article.
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity.
Haley du Bois, Taylor A Heim, Amanda W Lund.
Sci Immunol, 2021 Sep 14; 6(63). PMID: 34516744    Free PMC article.
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.
Francesco Marangoni, Ademi Zhakyp, +10 authors, Thorsten R Mempel.
Cell, 2021 Jun 23; 184(15). PMID: 34157302    Free PMC article.
Tumor metastasis: Mechanistic insights and therapeutic interventions.
Mengmeng Liu, Jing Yang, Bushu Xu, Xing Zhang.
MedComm (2020), 2022 Jan 04; 2(4). PMID: 34977870    Free PMC article.
Systematic analysis of CD39, CD103, CD137, and PD-1 as biomarkers for naturally occurring tumor antigen-specific TILs.
Monika A Eiva, Dalia K Omran, Jessica A Chacon, Daniel J Powell.
Eur J Immunol, 2021 Sep 11; 52(1). PMID: 34505280    Free PMC article.
TGF-β links glycolysis and immunosuppression in glioblastoma.
Lingli Gong, Li Ji, +2 authors, Jian Zou.
Histol Histopathol, 2021 Jul 30; 36(11). PMID: 34323284
Bone Morphogenetic Proteins Shape Treg Cells.
Piotr Kraj.
Front Immunol, 2022 Apr 15; 13. PMID: 35418975    Free PMC article.
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species.
Dinh Viet Hoang, Le Thi Thanh Thuy, +15 authors, Norifumi Kawada.
Oncogenesis, 2022 May 04; 11(1). PMID: 35504863    Free PMC article.
Cytokines: Can Cancer Get the Message?
Rachel M Morris, Toni O Mortimer, Kim L O'Neill.
Cancers (Basel), 2022 May 15; 14(9). PMID: 35565306    Free PMC article.
The tumor microenvironment of pancreatic adenocarcinoma and immune checkpoint inhibitor resistance: a perplex relationship.
Irem Sahin, Sevda Turen, Pranav Santapuram, Ibrahim Halil Sahin.
Cancer Drug Resist, 2020 Sep 04; 3(4). PMID: 35582227    Free PMC article.