Journal Article
. 2005 Feb; 174(5):2591-601.
doi: 10.4049/jimmunol.174.5.2591.

CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells

Paul A Antony 1 Ciriaco A Piccirillo  Akgül Akpinarli  Steven E Finkelstein  Paul J Speiss  Deborah R Surman  Douglas C Palmer  Chi-Chao Chan  Christopher A Klebanoff  Willem W Overwijk  Steven A Rosenberg  Nicholas P Restifo  
Affiliations
  • PMID: 15728465
  •     61 References
  •     312 citations

Abstract

CD4(+) T cells control the effector function, memory, and maintenance of CD8(+) T cells. Paradoxically, we found that absence of CD4(+) T cells enhanced adoptive immunotherapy of cancer when using CD8(+) T cells directed against a persisting tumor/self-Ag. However, adoptive transfer of CD4(+)CD25(-) Th cells (Th cells) with tumor/self-reactive CD8(+) T cells and vaccination into CD4(+) T cell-deficient hosts induced autoimmunity and regression of established melanoma. Transfer of CD4(+) T cells that contained a mixture of Th and CD4(+)CD25(+) T regulatory cells (T(reg) cells) or T(reg) cells alone prevented effective adoptive immunotherapy. Maintenance of CD8(+) T cell numbers and function was dependent on Th cells that were capable of IL-2 production because therapy failed when Th cells were derived from IL-2(-/-) mice. These findings reveal that Th cells can help break tolerance to a persisting self-Ag and treat established tumors through an IL-2-dependent mechanism, but requires simultaneous absence of naturally occurring T(reg) cells to be effective.

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Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study.
Amy B Heimberger, Wei Sun, +11 authors, John H Sampson.
Neuro Oncol, 2007 Dec 15; 10(1). PMID: 18079360    Free PMC article.
T-cell receptor gene therapy of established tumors in a murine melanoma model.
John D Abad, Claudia Wrzensinski, +12 authors, Richard A Morgan.
J Immunother, 2007 Dec 25; 31(1). PMID: 18157006    Free PMC article.
Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming.
Djordje Atanackovic, Nasser K Altorki, +7 authors, Sacha Gnjatic.
Proc Natl Acad Sci U S A, 2008 Jan 25; 105(5). PMID: 18216244    Free PMC article.
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain.
Robert M Prins, Chengyi J Shu, +9 authors, Linda M Liau.
Cancer Immunol Immunother, 2008 Feb 07; 57(9). PMID: 18253732    Free PMC article.
The control of CD4+CD25+Foxp3+ regulatory T cell survival.
Pushpa Pandiyan, Michael J Lenardo.
Biol Direct, 2008 Feb 29; 3. PMID: 18304352    Free PMC article.
Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma.
T Yoshioka, M Miyamoto, +13 authors, S Kondo.
Br J Cancer, 2008 Mar 20; 98(7). PMID: 18349839    Free PMC article.
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Pawel Muranski, Andrea Boni, +14 authors, Nicholas P Restifo.
Blood, 2008 Mar 21; 112(2). PMID: 18354038    Free PMC article.
Highly Cited.
Adoptive cell transfer: a clinical path to effective cancer immunotherapy.
Steven A Rosenberg, Nicholas P Restifo, +2 authors, Mark E Dudley.
Nat Rev Cancer, 2008 Mar 21; 8(4). PMID: 18354418    Free PMC article.
Highly Cited. Review.
The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells.
Heather J Symons, Moshe Y Levy, +6 authors, Ephraim J Fuchs.
Biol Blood Marrow Transplant, 2008 Apr 16; 14(5). PMID: 18410892    Free PMC article.
Epigenetics in human autoimmunity. Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond.
Faith M Strickland, Bruce C Richardson.
Autoimmunity, 2008 Apr 25; 41(4). PMID: 18432408    Free PMC article.
Review.
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.
Bianca Heemskerk, Ke Liu, +9 authors, Steven A Rosenberg.
Hum Gene Ther, 2008 May 01; 19(5). PMID: 18444786    Free PMC article.
Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration.
Daniel J Powell, Peter Attia, +3 authors, Steven A Rosenberg.
J Immunother, 2008 May 16; 31(2). PMID: 18481388    Free PMC article.
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells.
Brian G Till, Michael C Jensen, +13 authors, Oliver W Press.
Blood, 2008 May 30; 112(6). PMID: 18509084    Free PMC article.
Highly Cited.
CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus.
Roman Puliaev, Irina Puliaeva, +4 authors, Charles S Via.
J Immunol, 2008 Jun 21; 181(1). PMID: 18566369    Free PMC article.
Defective MHC class II presentation by dendritic cells limits CD4 T cell help for antitumor CD8 T cell responses.
Michael Y Gerner, Kerry A Casey, Matthew F Mescher.
J Immunol, 2008 Jun 21; 181(1). PMID: 18566380    Free PMC article.
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.
Sergio A Quezada, Karl S Peggs, +3 authors, James P Allison.
J Exp Med, 2008 Aug 30; 205(9). PMID: 18725522    Free PMC article.
Highly Cited.
Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells.
Zuqiang Liu, Hae S Noh, +3 authors, Zhaoyang You.
J Immunol, 2008 Sep 05; 181(6). PMID: 18768895    Free PMC article.
Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantation.
Katayoun Rezvani, A John Barrett.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790448    Free PMC article.
Review.
Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
Mark E Dudley, James C Yang, +17 authors, Steven A Rosenberg.
J Clin Oncol, 2008 Sep 24; 26(32). PMID: 18809613    Free PMC article.
Highly Cited.
FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions.
Mojgan Ahmadzadeh, Aloisio Felipe-Silva, +4 authors, Steven A Rosenberg.
Blood, 2008 Sep 30; 112(13). PMID: 18820132    Free PMC article.
Adoptive immunotherapy: good habits instilled at youth have long-term benefits.
Chrystal M Paulos, Megan M Suhoski, +10 authors, Carl H June.
Immunol Res, 2008 Oct 25; 42(1-3). PMID: 18949448    Free PMC article.
Review.
Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors.
Nicolas Larmonier, Nona Janikashvili, +6 authors, Emmanuel Katsanis.
J Immunol, 2008 Nov 05; 181(10). PMID: 18981115    Free PMC article.
In vitro induction of T cells that are resistant to A2 adenosine receptor-mediated immunosuppression.
Akio Ohta, J Kjaergaard, +6 authors, M Sitkovsky.
Br J Pharmacol, 2008 Dec 17; 156(2). PMID: 19076726    Free PMC article.
Regulatory T cells in renal disease.
Yuan Min Wang, Min Hu, +6 authors, Stephen I Alexander.
Int J Clin Exp Med, 2008 Dec 17; 1(4). PMID: 19079673    Free PMC article.
Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.
Chengyi J Shu, Caius G Radu, +5 authors, Owen N Witte.
Int Immunol, 2008 Dec 25; 21(2). PMID: 19106231    Free PMC article.
Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells.
Maria R Parkhurst, Jayne Joo, +4 authors, Steven A Rosenberg.
Clin Cancer Res, 2009 Jan 02; 15(1). PMID: 19118044    Free PMC article.
Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory.
Weiqing Jing, Jill A Gershan, Bryon D Johnson.
Blood, 2009 Feb 03; 113(18). PMID: 19182203    Free PMC article.
Use of tumour-responsive T cells as cancer treatment.
Mary L Disis, Helga Bernhard, Elizabeth M Jaffee.
Lancet, 2009 Feb 24; 373(9664). PMID: 19231634    Free PMC article.
Review.
Antigen processing and MHC-II presentation by dermal and tumor-infiltrating dendritic cells.
Michael Y Gerner, Matthew F Mescher.
J Immunol, 2009 Feb 24; 182(5). PMID: 19234167    Free PMC article.
Adoptive immunotherapy of cancer using CD4(+) T cells.
Pawel Muranski, Nicholas P Restifo.
Curr Opin Immunol, 2009 Mar 17; 21(2). PMID: 19285848    Free PMC article.
Highly Cited. Review.
Adoptive cell therapy for the treatment of patients with metastatic melanoma.
Steven A Rosenberg, Mark E Dudley.
Curr Opin Immunol, 2009 Mar 24; 21(2). PMID: 19304471    Free PMC article.
Highly Cited. Review.
Tumor regulatory T cells potently abrogate antitumor immunity.
Zuqiang Liu, Jin H Kim, Louis D Falo, Zhaoyang You.
J Immunol, 2009 May 06; 182(10). PMID: 19414769    Free PMC article.
Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia.
Miroslaw J Szczepanski, Marta Szajnik, +6 authors, Michael Boyiadzis.
Clin Cancer Res, 2009 May 07; 15(10). PMID: 19417016    Free PMC article.
Therapeutic immunity by adoptive tumor-primed CD4(+) T-cell transfer in combination with in vivo GITR ligation.
Zuqiang Liu, Shenghe Tian, +2 authors, Zhaoyang You.
Mol Ther, 2009 May 07; 17(7). PMID: 19417739    Free PMC article.
Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer.
Seagal Teitz-Tennenbaum, Qiao Li, +4 authors, Alfred E Chang.
J Immunother, 2009 Jun 02; 32(6). PMID: 19483649    Free PMC article.
High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.
Andrew G Brandmaier, Wolfgang W Leitner, +3 authors, Christopher E Touloukian.
J Immunother, 2009 Jun 30; 32(7). PMID: 19561540    Free PMC article.
The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients.
Amy B Heimberger, John H Sampson.
Expert Opin Biol Ther, 2009 Jul 14; 9(8). PMID: 19591631    Free PMC article.
Review.
Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells.
Kimberly A Shafer-Weaver, Stephanie K Watkins, +5 authors, Arthur A Hurwitz.
Cancer Res, 2009 Jul 23; 69(15). PMID: 19622771    Free PMC article.
Treatment of lymphoma with adoptively transferred T cells.
Brian G Till, Oliver W Press.
Expert Opin Biol Ther, 2009 Sep 03; 9(11). PMID: 19723016    Free PMC article.
Review.
IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors.
Kotaro Sasaki, Angela D Pardee, +10 authors, Walter J Storkus.
J Immunother, 2009 Sep 16; 32(8). PMID: 19752754    Free PMC article.
Regulatory T cells and immune tolerance to tumors.
Xuefang Cao.
Immunol Res, 2009 Sep 19; 46(1-3). PMID: 19763889
Review.
Antitumor immunity and cancer stem cells.
Tobias Schatton, Markus H Frank.
Ann N Y Acad Sci, 2009 Oct 03; 1176. PMID: 19796244    Free PMC article.
Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.
Douglas C Palmer, Nicholas P Restifo.
Trends Immunol, 2009 Nov 03; 30(12). PMID: 19879803    Free PMC article.
Review.
Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination.
Mohamed Labib Salem, David J Cole.
Cancer Immunol Immunother, 2009 Nov 19; 59(3). PMID: 19921513    Free PMC article.
Review.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
William Humphries, Jun Wei, John H Sampson, Amy B Heimberger.
Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972    Free PMC article.
Review.
Antitumor effect of mSurvivinThr34→Ala in murine colon carcinoma when administered intravenously.
Hong-xia Li, Xin-yu Zhao, +16 authors, Xia Zhao.
Med Oncol, 2009 Dec 02; 27(4). PMID: 19949901
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.
Claudia Wrzesinski, Chrystal M Paulos, +6 authors, Nicholas P Restifo.
J Immunother, 2009 Dec 03; 33(1). PMID: 19952961    Free PMC article.
Highly Cited.
Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo.
Mohamed L Salem, Sabry A El-Naggar, David J Cole.
Cell Immunol, 2009 Dec 29; 261(2). PMID: 20036354    Free PMC article.
Pilot study of sentinel-node-based adoptive immunotherapy in advanced colorectal cancer.
Mona Karlsson, Per Marits, +4 authors, Ola Winqvist.
Ann Surg Oncol, 2010 Feb 02; 17(7). PMID: 20119674    Free PMC article.
Cytokine working group study of lymphodepleting chemotherapy, interleukin-2, and granulocyte-macrophage colony-stimulating factor in patients with metastatic melanoma: clinical outcomes and peripheral-blood cell recovery.
Krishna S Gunturu, Kenneth R Meehan, +13 authors, Marc S Ernstoff.
J Clin Oncol, 2010 Feb 04; 28(7). PMID: 20124177    Free PMC article.
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
Sergio A Quezada, Tyler R Simpson, +9 authors, James P Allison.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156971    Free PMC article.
Highly Cited.
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
Ying Xie, Akgül Akpinarli, +6 authors, Paul Andrew Antony.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156973    Free PMC article.
Highly Cited.
The role of regulatory T cells in cancer.
Tai-You Ha.
Immune Netw, 2010 Feb 17; 9(6). PMID: 20157609    Free PMC article.
Redirecting the immune response: role of adoptive T cell therapy.
Anna Mondino, Valérie Dardalhon, +2 authors, Naomi Taylor.
Hum Gene Ther, 2010 Mar 06; 21(5). PMID: 20201627    Free PMC article.
Review.
T(H)17 cells in tumour immunity and immunotherapy.
Weiping Zou, Nicholas P Restifo.
Nat Rev Immunol, 2010 Mar 26; 10(4). PMID: 20336152    Free PMC article.
Highly Cited. Review.
Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation.
Lisa D S Johnson, Stephen C Jameson.
J Immunol, 2010 Apr 16; 184(10). PMID: 20393139    Free PMC article.
Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.
Timothy L Frankel, William R Burns, +7 authors, Richard A Morgan.
J Immunol, 2010 Apr 30; 184(11). PMID: 20427771    Free PMC article.
Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells.
James N Kochenderfer, Zhiya Yu, +2 authors, Steven A Rosenberg.
Blood, 2010 Jul 16; 116(19). PMID: 20631379    Free PMC article.
Highly Cited.
Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses.
Jonathan S Kurche, Matthew A Burchill, +2 authors, Ross M Kedl.
J Immunol, 2010 Jul 20; 185(4). PMID: 20639485    Free PMC article.
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.
Sid P Kerkar, Pawel Muranski, +12 authors, Nicholas P Restifo.
Cancer Res, 2010 Jul 22; 70(17). PMID: 20647327    Free PMC article.
Highly Cited.
CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma.
Mark E Dudley, Colin A Gross, +17 authors, Steven A Rosenberg.
Clin Cancer Res, 2010 Jul 30; 16(24). PMID: 20668005    Free PMC article.
Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine.
M Eric Kohler, William H D Hallett, +3 authors, Rimas J Orentas.
Cell Immunol, 2010 Aug 10; 265(1). PMID: 20692654    Free PMC article.
Dendritic cells: are they clinically relevant?
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693842    Free PMC article.
Review.
A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors.
Matthew J Goldstein, Bindu Varghese, +5 authors, Ronald Levy.
Blood, 2010 Sep 30; 117(1). PMID: 20876455    Free PMC article.
Designing vaccines based on biology of human dendritic cell subsets.
Karolina Palucka, Jacques Banchereau, Ira Mellman.
Immunity, 2010 Oct 30; 33(4). PMID: 21029958    Free PMC article.
Highly Cited. Review.
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Nona Janikashvili, Collin J LaCasse, +7 authors, Emmanuel Katsanis.
Blood, 2010 Dec 03; 117(5). PMID: 21123824    Free PMC article.
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.
Madhav D Sharma, De-Yan Hou, +6 authors, David H Munn.
Immunity, 2010 Dec 15; 33(6). PMID: 21145762    Free PMC article.
Highly Cited.
Dendritic cells and immunity against cancer.
K Palucka, H Ueno, J Fay, J Banchereau.
J Intern Med, 2010 Dec 17; 269(1). PMID: 21158979    Free PMC article.
Review.
Therapeutic cancer vaccines: are we there yet?
Christopher A Klebanoff, Nicolas Acquavella, Zhiya Yu, Nicholas P Restifo.
Immunol Rev, 2011 Jan 05; 239(1). PMID: 21198663    Free PMC article.
Highly Cited. Review.
Immunization delivered by lentiviral vectors for cancer and infectious diseases.
Biliang Hu, April Tai, Pin Wang.
Immunol Rev, 2011 Jan 05; 239(1). PMID: 21198664    Free PMC article.
Review.
Focus on adoptive T cell transfer trials in melanoma.
Liat Hershkovitz, Jacob Schachter, Avraham J Treves, Michal J Besser.
Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234353    Free PMC article.
Review.
Recent developments in cancer vaccines.
Karolina Palucka, Hideki Ueno, Jacques Banchereau.
J Immunol, 2011 Jan 21; 186(3). PMID: 21248270    Free PMC article.
Review.
Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools.
Bruno Zaragoza, César Evaristo, +5 authors, Afonso R M Almeida.
PLoS One, 2011 Mar 23; 6(3). PMID: 21423804    Free PMC article.
Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy.
Carlos A Ramos, Gianpietro Dotti.
Expert Opin Biol Ther, 2011 Apr 06; 11(7). PMID: 21463133    Free PMC article.
Review.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Steven A Rosenberg, James C Yang, +12 authors, Mark E Dudley.
Clin Cancer Res, 2011 Apr 19; 17(13). PMID: 21498393    Free PMC article.
Highly Cited.
Depletion of CD25⁺ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma.
Weiqing Jing, Xiaocai Yan, +2 authors, Bryon D Johnson.
Blood, 2011 Apr 28; 117(25). PMID: 21521781    Free PMC article.
HLA antigen and NK cell activating ligand expression in malignant cells: a story of loss or acquisition.
Michael Campoli, Soldano Ferrone.
Semin Immunopathol, 2011 Apr 28; 33(4). PMID: 21523560    Free PMC article.
Review.
Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells.
Marcus O Butler, Philip Friedlander, +19 authors, Naoto Hirano.
Sci Transl Med, 2011 Apr 29; 3(80). PMID: 21525398    Free PMC article.
Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy.
S Merims, X Li, +7 authors, L Zhang.
Leukemia, 2011 May 14; 25(9). PMID: 21566657    Free PMC article.
Randomized multicenter trial of the effects of melanoma-associated helper peptides and cyclophosphamide on the immunogenicity of a multipeptide melanoma vaccine.
Craig L Slingluff, Gina R Petroni, +5 authors, William W Grosh.
J Clin Oncol, 2011 Jun 22; 29(21). PMID: 21690475    Free PMC article.
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes.
Qunrui Ye, Maria Loisiou, +5 authors, Daniel J Powell.
J Transl Med, 2011 Aug 11; 9. PMID: 21827675    Free PMC article.
Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes.
Teodora Mocan, Cornel Iancu.
Int J Nanomedicine, 2011 Oct 07; 6. PMID: 21976971    Free PMC article.
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.
Anik L Côté, Katelyn T Byrne, +2 authors, Mary Jo Turk.
PLoS One, 2011 Nov 03; 6(10). PMID: 22046294    Free PMC article.
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.
Sid P Kerkar, Romina S Goldszmid, +10 authors, Nicholas P Restifo.
J Clin Invest, 2011 Nov 08; 121(12). PMID: 22056381    Free PMC article.
Highly Cited.
T cells and adoptive immunotherapy: recent developments and future prospects in gastrointestinal oncology.
Amedeo Amedei, Elena Niccolai, Mario M D'Elios.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110523    Free PMC article.
Review.
The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier.
Clin Dev Immunol, 2011 Nov 24; 2011. PMID: 22110524    Free PMC article.
Review.
Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma.
Christopher Schutt, Klaus Bumm, +9 authors, Maurizio Chiriva-Internati.
Int Rev Immunol, 2012 Jan 19; 31(1). PMID: 22251006    Free PMC article.
Review.
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin.
John E Harris, Tajie H Harris, +3 authors, Laurence A Turka.
J Invest Dermatol, 2012 Feb 03; 132(7). PMID: 22297636    Free PMC article.
Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells.
Vivian L Weiss, Timothy H Lee, +5 authors, Todd D Armstrong.
PLoS One, 2012 Feb 24; 7(2). PMID: 22359647    Free PMC article.
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
John H Sampson, Robert J Schmittling, +13 authors, Duane A Mitchell.
PLoS One, 2012 Mar 03; 7(2). PMID: 22383993    Free PMC article.
Cytotoxic chemotherapy and CD4+ effector T cells: an emerging alliance for durable antitumor effects.
Zhi-Chun Ding, Gang Zhou.
Clin Dev Immunol, 2012 Mar 09; 2012. PMID: 22400040    Free PMC article.
Review.
B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma.
Dong Hua, Jing Sun, +3 authors, Xue-Guang Zhang.
World J Gastroenterol, 2012 Mar 13; 18(9). PMID: 22408358    Free PMC article.
Cancer immunotherapy via dendritic cells.
Karolina Palucka, Jacques Banchereau.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871    Free PMC article.
Highly Cited. Review.
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
Advances in the treatment of metastatic melanoma: adoptive T-cell therapy.
Chantale Bernatchez, Laszlo G Radvanyi, Patrick Hwu.
Semin Oncol, 2012 Apr 10; 39(2). PMID: 22484193    Free PMC article.
Review.
T-regulatory cells: key players in tumor immune escape and angiogenesis.
Andrea Facciabene, Gregory T Motz, George Coukos.
Cancer Res, 2012 May 03; 72(9). PMID: 22549946    Free PMC article.
Highly Cited. Review.
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide.
Mohamed L Salem, Amir A Al-Khami, +4 authors, David J Cole.
Cell Immunol, 2012 May 09; 276(1-2). PMID: 22560674    Free PMC article.
Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.
Dalya R Soond, Fabien Garçon, +5 authors, Klaus Okkenhaug.
J Immunol, 2012 May 23; 188(12). PMID: 22611241    Free PMC article.
Absence of CD4 T-cell help provides a robust CD8 T-cell response while inducing effective memory in a preclinical model of melanoma.
Maria Muccioli, Caitlin Longstaff, Fabian Benencia.
Immunotherapy, 2012 May 31; 4(5). PMID: 22642330    Free PMC article.
Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model.
Afonso R M Almeida, Inês F Amado, +4 authors, Antonio A Freitas.
Front Immunol, 2012 Jun 02; 3. PMID: 22654881    Free PMC article.
T cells in gastric cancer: friends or foes.
Amedeo Amedei, Chiara Della Bella, +2 authors, Mario M D'Elios.
Clin Dev Immunol, 2012 Jun 14; 2012. PMID: 22693525    Free PMC article.
Review.
Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.
Shawn M Jensen, Christopher G Twitty, +6 authors, Bernard A Fox.
J Immunol, 2012 Jun 23; 189(2). PMID: 22723522    Free PMC article.
DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time.
Lindsey Chudley, Katy McCann, +13 authors, Christian Ottensmeier.
Cancer Immunol Immunother, 2012 Jun 26; 61(11). PMID: 22729556    Free PMC article.
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway.
Akio Ohta, Radhika Kini, +3 authors, Michail Sitkovsky.
Front Immunol, 2012 Jul 12; 3. PMID: 22783261    Free PMC article.
Highly Cited.
Adoptive immunotherapy of advanced melanoma.
Ronnie Shapira-Frommer, Jacob Schachter.
Curr Treat Options Oncol, 2012 Aug 07; 13(3). PMID: 22864561
Review.
MHC class II/ESO tetramer-based generation of in vitro primed anti-tumor T-helper lines for adoptive cell therapy of cancer.
Caroline Poli, Caroline Raffin, +3 authors, Danila Valmori.
Haematologica, 2012 Aug 10; 98(2). PMID: 22875619    Free PMC article.
Tumor-infiltrating lymphocytes in melanoma.
Sylvia Lee, Kim Margolin.
Curr Oncol Rep, 2012 Aug 11; 14(5). PMID: 22878966    Free PMC article.
Review.
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
Carolina M Soto, Jennifer D Stone, +4 authors, David M Kranz.
Cancer Immunol Immunother, 2012 Aug 29; 62(2). PMID: 22926060    Free PMC article.
Augmentation of anti-tumor immunity by adoptive T-cell transfer after allogeneic hematopoietic stem cell transplantation.
Marie Bleakley, Cameron J Turtle, Stanley R Riddell.
Expert Rev Hematol, 2012 Sep 21; 5(4). PMID: 22992235    Free PMC article.
Review.
Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.
Steven C Katz, Zubin M Bamboat, +9 authors, Ronald P DeMatteo.
Ann Surg Oncol, 2012 Sep 27; 20(3). PMID: 23010736    Free PMC article.
Isolation of human MHC class II-restricted T cell receptors from the autologous T-cell repertoire with potent anti-leukaemic reactivity.
Luise U Weigand, Xiaoling Liang, +8 authors, Angela M Krackhardt.
Immunology, 2012 Oct 03; 137(3). PMID: 23025755    Free PMC article.
Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.
Wiebke Hansen, Marina Hutzler, +10 authors, Iris Helfrich.
J Exp Med, 2012 Oct 10; 209(11). PMID: 23045606    Free PMC article.
Highly Cited.
Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras.
Hui Wang, Yanping Yang, +4 authors, Yong-Guang Yang.
PLoS One, 2012 Oct 19; 7(10). PMID: 23077554    Free PMC article.
Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?
Christopher A Klebanoff, Luca Gattinoni, Nicholas P Restifo.
J Immunother, 2012 Oct 24; 35(9). PMID: 23090074    Free PMC article.
Highly Cited. Review.
The past, present, and future of adoptive T cell therapy.
Donghoon Choi, Tai-Gyu Kim, Young Chul Sung.
Immune Netw, 2012 Oct 24; 12(4). PMID: 23091437    Free PMC article.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Review.
Clinical opportunities in combining immunotherapy with radiation therapy.
Steven E Finkelstein, Mayer Fishman.
Front Oncol, 2012 Dec 13; 2. PMID: 23233905    Free PMC article.
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
Byram W Bridle, Lan Chen, +9 authors, Yonghong Wan.
Mol Ther, 2013 Jan 09; 21(4). PMID: 23295947    Free PMC article.
Effects of tumor irradiation on host T-regulatory cells and systemic immunity in the context of adoptive T-cell therapy in mice.
Shuang Wei, Martin U Egenti, +2 authors, Alfred E Chang.
J Immunother, 2013 Feb 05; 36(2). PMID: 23377667    Free PMC article.
Influence of tumors on protective anti-tumor immunity and the effects of irradiation.
Gemma A Foulds, Jürgen Radons, +2 authors, Alan G Pockley.
Front Oncol, 2013 Feb 05; 3. PMID: 23378947    Free PMC article.
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.
Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536636    Free PMC article.
Highly Cited.
GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.
Angela X Zhou, Lina Kozhaya, Hodaka Fujii, Derya Unutmaz.
J Immunol, 2013 Apr 12; 190(10). PMID: 23576681    Free PMC article.
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Boris Engels, Victor H Engelhard, +7 authors, Hans Schreiber.
Cancer Cell, 2013 Apr 20; 23(4). PMID: 23597565    Free PMC article.
Chemotherapy in the management of advanced cutaneous malignant melanoma.
Jason J Luke, Gary K Schwartz.
Clin Dermatol, 2013 Apr 24; 31(3). PMID: 23608448    Free PMC article.
Review.
An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.
Madhav D Sharma, Lei Huang, +9 authors, David H Munn.
Immunity, 2013 May 21; 38(5). PMID: 23684987    Free PMC article.
Highly Cited.
Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells.
Arnaud Pommier, Alexandra Audemard, +10 authors, Armelle Prévost-Blondel.
Proc Natl Acad Sci U S A, 2013 Jul 24; 110(32). PMID: 23878221    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus.
Sarene Koh, Noriko Shimasaki, +11 authors, Antonio Bertoletti.
Mol Ther Nucleic Acids, 2013 Aug 15; 2. PMID: 23941866    Free PMC article.
Antitumor effect of embryonic stem cells in a non-small cell lung cancer model: antitumor factors and immune responses.
Wei Dong, Chen Qiu, +2 authors, Jiajun Du.
Int J Med Sci, 2013 Aug 29; 10(10). PMID: 23983591    Free PMC article.
Reassessing target antigens for adoptive T-cell therapy.
Christian S Hinrichs, Nicholas P Restifo.
Nat Biotechnol, 2013 Oct 22; 31(11). PMID: 24142051    Free PMC article.
Highly Cited. Review.
TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu.
Andre Kunert, Trudy Straetemans, +4 authors, Reno Debets.
Front Immunol, 2013 Nov 23; 4. PMID: 24265631    Free PMC article.
Review.
Epitope analysis of the collagen type V-specific T cell response in lung transplantation reveals an HLA-DRB1*15 bias in both recipient and donor.
Melissa R Keller, Lynn D Haynes, +4 authors, William J Burlingham.
PLoS One, 2013 Nov 23; 8(11). PMID: 24265781    Free PMC article.
Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy.
Joshua P Landreneau, Michael R Shurin, +3 authors, Galina V Shurin.
Cancer Microenviron, 2013 Dec 03; 8(2). PMID: 24293116    Free PMC article.
Exploiting the curative potential of adoptive T-cell therapy for cancer.
Christian S Hinrichs, Steven A Rosenberg.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329789    Free PMC article.
Highly Cited. Review.
Enhanced responses to tumor immunization following total body irradiation are time-dependent.
Adi Diab, Robert R Jenq, +14 authors, Miguel-Angel Perales.
PLoS One, 2013 Dec 19; 8(12). PMID: 24349298    Free PMC article.
T cell avidity and tumor immunity: problems and solutions.
Arthur A Hurwitz, Steven M Cuss, Katherine E Stagliano, Ziqiang Zhu.
Cancer Microenviron, 2013 Dec 21; 7(1-2). PMID: 24357332    Free PMC article.
Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion.
Pavan Bachireddy, Ursula Hainz, +15 authors, Catherine J Wu.
Blood, 2013 Dec 21; 123(9). PMID: 24357730    Free PMC article.
Preimmunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation.
Koji Suzuki, Kouichirou Aida, +5 authors, Kazunori Aoki.
Cancer Med, 2014 Jan 10; 2(5). PMID: 24403229    Free PMC article.
Low GILT Expression is Associated with Poor Patient Survival in Diffuse Large B-Cell Lymphoma.
Hannah Phipps-Yonas, Haiyan Cui, +7 authors, Karen Taraszka Hastings.
Front Immunol, 2014 Jan 11; 4. PMID: 24409177    Free PMC article.
Immunotherapy for solid tumors--a review for surgeons.
Abdul Saied, Venu G Pillarisetty, Steven C Katz.
J Surg Res, 2014 Feb 04; 187(2). PMID: 24485876    Free PMC article.
Review.
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.
Yichen Tang, Xuejun Xu, +6 authors, Huaizhi Wang.
PLoS One, 2014 Mar 19; 9(3). PMID: 24637664    Free PMC article.
Highly Cited.
Human melanoma metastases demonstrate nonstochastic site-specific antigen heterogeneity that correlates with T-cell infiltration.
Edmund K Bartlett, Patricia A Fetsch, +8 authors, Udai S Kammula.
Clin Cancer Res, 2014 Mar 22; 20(10). PMID: 24647571    Free PMC article.
Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications.
Zhixue Zheng, Zhaode Bu, +10 authors, Jiafu Ji.
Chin J Cancer Res, 2014 Mar 22; 26(1). PMID: 24653632    Free PMC article.
CD19-CAR trials.
Carlos A Ramos, Barbara Savoldo, Gianpietro Dotti.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667955    Free PMC article.
Review.
MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial.
Emanuela Romano, Olivier Michielin, +8 authors, Alexandre Harari.
J Transl Med, 2014 Apr 15; 12. PMID: 24726012    Free PMC article.
Zonal difference and prognostic significance of foxp3 regulatory T cell infiltration in breast cancer.
Sewha Kim, Anbok Lee, +5 authors, Sun Hee Sung.
J Breast Cancer, 2014 Apr 20; 17(1). PMID: 24744792    Free PMC article.
Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production.
Shaun O'Brien, Rajan M Thomas, +3 authors, Andrew D Wells.
J Immunol, 2014 Apr 30; 192(11). PMID: 24778448    Free PMC article.
How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
Ole Audun Werner Haabeth, Anders Aune Tveita, +8 authors, Bjarne Bogen.
Front Immunol, 2014 May 02; 5. PMID: 24782871    Free PMC article.
Highly Cited. Review.
Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing.
Yun Ji, Natalie Abrams, +9 authors, Nicholas P Restifo.
PLoS One, 2014 May 16; 9(5). PMID: 24827921    Free PMC article.
Selective inhibition of regulatory T cells by targeting the PI3K-Akt pathway.
Rasha Abu-Eid, Raed N Samara, +5 authors, Samir N Khleif.
Cancer Immunol Res, 2014 Aug 01; 2(11). PMID: 25080445    Free PMC article.
T-cell immunotherapy: looking forward.
Jacqueline Corrigan-Curay, Hans-Peter Kiem, +23 authors, Donald B Kohn.
Mol Ther, 2014 Sep 05; 22(9). PMID: 25186558    Free PMC article.
Antigen-specific vaccines for cancer treatment.
Maria Tagliamonte, Annacarmen Petrizzo, +2 authors, Luigi Buonaguro.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483639    Free PMC article.
Review.
Novel immunotherapies for hematologic malignancies.
Michelle H Nelson, Chrystal M Paulos.
Immunol Rev, 2014 Dec 17; 263(1). PMID: 25510273    Free PMC article.
Review.
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.
Yun Ji, Claudia Wrzesinski, +14 authors, Luca Gattinoni.
Proc Natl Acad Sci U S A, 2014 Dec 31; 112(2). PMID: 25548153    Free PMC article.
Plasticity of human CD4 T cell subsets.
Jens Geginat, Moira Paroni, +6 authors, Sergio Abrignani.
Front Immunol, 2015 Jan 08; 5. PMID: 25566245    Free PMC article.
Highly Cited. Review.
Metastatic melanoma cells evade immune detection by silencing STAT1.
JoDi Lynn Osborn, Susanna F Greer.
Int J Mol Sci, 2015 Feb 19; 16(2). PMID: 25690042    Free PMC article.
Methionine enkephalin (MENK) inhibits tumor growth through regulating CD4+Foxp3+ regulatory T cells (Tregs) in mice.
Xuan Li, Yiming Meng, +5 authors, Fengping Shan.
Cancer Biol Ther, 2015 Feb 24; 16(3). PMID: 25701137    Free PMC article.
Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.
Ivan Liadi, Harjeet Singh, +9 authors, Navin Varadarajan.
Cancer Immunol Res, 2015 Feb 26; 3(5). PMID: 25711538    Free PMC article.
Immunotherapy for malignant glioma.
Carter M Suryadevara, Terence Verla, +4 authors, John H Sampson.
Surg Neurol Int, 2015 Feb 28; 6(Suppl 1). PMID: 25722935    Free PMC article.
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.
Jacob S Bowers, Michelle H Nelson, +6 authors, Chrystal M Paulos.
Clin Cancer Res, 2015 Apr 24; 21(11). PMID: 25904754    Free PMC article.
Autologous cellular vaccine overcomes cancer immunoediting in a mouse model of myeloma.
Marta Mazzocco, Matteo Martini, +12 authors, Silvia Sartoris.
Immunology, 2015 May 12; 146(1). PMID: 25959091    Free PMC article.
Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity.
Yunfei Zhang, Yong Zhang, +2 authors, Wen Luo.
PLoS One, 2015 May 12; 10(5). PMID: 25961716    Free PMC article.
Systemic LPS Translocation Activates Cross-Presenting Dendritic Cells but Is Dispensable for the Breakdown of CD8+ T Cell Peripheral Tolerance in Irradiated Mice.
Gabriel Espinosa-Carrasco, Marine Villard, +3 authors, Javier Hernandez.
PLoS One, 2015 Jun 16; 10(6). PMID: 26075613    Free PMC article.
Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.
H Fujiwara, T Ochi, +8 authors, M Yasukawa.
Leukemia, 2015 Jun 25; 29(12). PMID: 26104661
CAR-T Cell Therapy for Lymphoma.
Carlos A Ramos, Helen E Heslop, Malcolm K Brenner.
Annu Rev Med, 2015 Sep 04; 67. PMID: 26332003    Free PMC article.
Review.
Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine.
Jeanne Galaine, Christophe Borg, Yann Godet, Olivier Adotévi.
Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350591    Free PMC article.
Review.
Immunosuppression associated with chronic inflammation in the tumor microenvironment.
Dingzhi Wang, Raymond N DuBois.
Carcinogenesis, 2015 Sep 12; 36(10). PMID: 26354776    Free PMC article.
Highly Cited. Review.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Kyle A Wilson, Stephen R Goding, +2 authors, Paul Andrew Antony.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570    Free PMC article.
Plasma membrane vesicles decorated with glycolipid-anchored antigens and adjuvants via protein transfer as an antigen delivery platform for inhibition of tumor growth.
Jaina M Patel, Vincent F Vartabedian, +7 authors, Periasamy Selvaraj.
Biomaterials, 2015 Oct 16; 74. PMID: 26461116    Free PMC article.
Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma.
Zipei Feng, Sachin Puri, +7 authors, Bernard A Fox.
J Immunother Cancer, 2015 Oct 27; 3. PMID: 26500776    Free PMC article.
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.
Douglas C Palmer, Geoffrey C Guittard, +17 authors, Nicholas P Restifo.
J Exp Med, 2015 Nov 04; 212(12). PMID: 26527801    Free PMC article.
T-cell receptor gene therapy--ready to go viral?
Terhi Karpanen, Johanna Olweus.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533    Free PMC article.
Review.
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy.
Payal Mittal, Marie-Clare St Rose, +4 authors, Adam J Adler.
J Immunol, 2015 Nov 13; 195(12). PMID: 26561553    Free PMC article.
Tumor-infiltrating lymphocytes for the treatment of metastatic cancer.
M H Geukes Foppen, M Donia, I M Svane, J B A G Haanen.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578452    Free PMC article.
Review.
Role of interferon-γ and cytotoxic T lymphocytes in intraocular tumor rejection.
Ann J Ligocki, Joseph R Brown, Jerry Y Niederkorn.
J Leukoc Biol, 2015 Nov 19; 99(5). PMID: 26578649    Free PMC article.
Toxicities Associated With Adoptive T-Cell Transfer for Cancer.
James C Yang.
Cancer J, 2015 Nov 21; 21(6). PMID: 26588684    Free PMC article.
Review.
The Promise of Chimeric Antigen Receptor Engineered T Cells in the Treatment of Hematologic Malignancies.
Sarah J Nagle, Alfred L Garfall, Edward A Stadtmauer.
Cancer J, 2016 Feb 04; 22(1). PMID: 26841014    Free PMC article.
Review.
Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning.
Michelle H Nelson, Jacob S Bowers, +7 authors, Chrystal M Paulos.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885368    Free PMC article.
Strategies to genetically engineer T cells for cancer immunotherapy.
Timothy T Spear, Kaoru Nagato, Michael I Nishimura.
Cancer Immunol Immunother, 2016 May 04; 65(6). PMID: 27138532    Free PMC article.
Review.
Anticancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response.
Jessie Thalmensi, Elodie Pliquet, +12 authors, Pierre Langlade-Demoyen.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141336    Free PMC article.
A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.
Carmen S M Yong, Liza B John, +5 authors, Michael H Kershaw.
Oncotarget, 2016 May 07; 7(23). PMID: 27153556    Free PMC article.
Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy.
Xin Yao, Yong-Chen Lu, +8 authors, Paul F Robbins.
J Immunother, 2016 May 11; 39(5). PMID: 27163739    Free PMC article.
Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression.
Emily R Mercadante, Ulrike M Lorenz.
Front Immunol, 2016 Jun 01; 7. PMID: 27242798    Free PMC article.
Review.
Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells.
Nicolas Goudin, Pascal Chappert, +3 authors, Orly Azogui.
PLoS One, 2016 Jun 25; 11(6). PMID: 27341421    Free PMC article.
Restoring anti-oncodriver Th1 responses with dendritic cell vaccines in HER2/neu-positive breast cancer: progress and potential.
Lucy M De La Cruz, Nadia F Nocera, Brian J Czerniecki.
Immunotherapy, 2016 Sep 09; 8(10). PMID: 27605070    Free PMC article.
Review.
Effect of systemic injection of heterogenous and homogenous opioids on peripheral cellular immune response in rats with bone cancer pain: A comparative study.
Jun-Ying Du, Yi Liang, +4 authors, Jian-Qiao Fang.
Exp Ther Med, 2016 Oct 06; 12(4). PMID: 27703511    Free PMC article.
Exogenous IL-2 Induces FoxP3+ Th17 Cells In Vivo in Melanoma Patients.
Maggie L Diller, Ragini R Kudchadkar, +2 authors, Mandy L Ford.
J Immunother, 2016 Oct 16; 39(9). PMID: 27741090    Free PMC article.
Understanding mechanisms of autoimmunity through translational research in vitiligo.
James P Strassner, John E Harris.
Curr Opin Immunol, 2016 Oct 21; 43. PMID: 27764715    Free PMC article.
Review.
Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.
Liqing Wang, Suresh Kumar, +17 authors, Wayne W Hancock.
EBioMedicine, 2016 Oct 30; 13. PMID: 27769803    Free PMC article.
Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells.
Shu Wang, Jose Campos, +5 authors, Cristiana Guiducci.
Proc Natl Acad Sci U S A, 2016 Nov 02; 113(46). PMID: 27799536    Free PMC article.
Highly Cited.
Generation of T cell effectors using tumor cell-loaded dendritic cells for adoptive T cell therapy.
Katerina Vavrova, Petra Vrabcova, +2 authors, Rudolf Horvath.
Med Oncol, 2016 Nov 05; 33(12). PMID: 27812850
Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy.
Shuhong Qi, Hui Li, +7 authors, Zhihong Zhang.
Elife, 2016 Nov 20; 5. PMID: 27855783    Free PMC article.
Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer.
Michel van Gelder, Ariane Vanclée, +3 authors, Gerard M Bos.
Breast Cancer Res Treat, 2016 Dec 05; 161(3). PMID: 27915436    Free PMC article.
A polyethylenimine-modified carboxyl-poly(styrene/acrylamide) copolymer nanosphere for co-delivering of CpG and TGF-β receptor I inhibitor with remarkable additive tumor regression effect against liver cancer in mice.
Shuyan Liang, Jun Hu, +3 authors, Xiangliang Yang.
Int J Nanomedicine, 2016 Dec 23; 11. PMID: 28008250    Free PMC article.
Combination immunotherapy: a road map.
Patrick A Ott, F Stephen Hodi, +2 authors, Jedd D Wolchok.
J Immunother Cancer, 2017 Feb 28; 5. PMID: 28239469    Free PMC article.
Highly Cited. Review.
Immune Effector Recovery in Chronic Myeloid Leukemia and Treatment-Free Remission.
Amy Hughes, Agnes S M Yong.
Front Immunol, 2017 May 10; 8. PMID: 28484463    Free PMC article.
Review.
Novel "Elements" of Immune Suppression within the Tumor Microenvironment.
Devikala Gurusamy, David Clever, Robert Eil, Nicholas P Restifo.
Cancer Immunol Res, 2017 Jun 04; 5(6). PMID: 28576921    Free PMC article.
Review.
Enhanced immune response induced by P5 HER2/neu-derived peptide-pulsed dendritic cells as a preventive cancer vaccine.
Zahra Gholizadeh, Jalil Tavakkol-Afshari, +2 authors, Mahmoud Reza Jaafari.
J Cell Mol Med, 2017 Sep 26; 22(1). PMID: 28944998    Free PMC article.
Lambda phage nanoparticles displaying HER2-derived E75 peptide induce effective E75-CD8+ T response.
Atefeh Arab, Jessica Nicastro, +8 authors, Javad Behravan.
Immunol Res, 2017 Nov 17; 66(1). PMID: 29143917
Modulation of antitumor immunity with histone deacetylase inhibitors.
Tyler R McCaw, Troy D Randall, Andres Forero, Donald J Buchsbaum.
Immunotherapy, 2017 Dec 01; 9(16). PMID: 29185390    Free PMC article.
Review.
Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60.
Feng Wang, Liqing Wang, +8 authors, Suresh Kumar.
PLoS One, 2017 Dec 14; 12(12). PMID: 29236775    Free PMC article.
Antigenic expression and spontaneous immune responses support the use of a selected peptide set from the IMA950 glioblastoma vaccine for immunotherapy of grade II and III glioma.
Valérie Dutoit, Denis Migliorini, +10 authors, Pierre-Yves Dietrich.
Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308320    Free PMC article.
Immunotherapy of cancer: targeting cancer during active disease or during dormancy?
Syed Ammer Shah, Melika Zarei, +3 authors, Masoud H Manjili.
Immunotherapy, 2018 Jan 18; 9(11). PMID: 29338608    Free PMC article.
Review.
Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma.
Katarzyna C Pituch, Jason Miska, +8 authors, Irina V Balyasnikova.
Mol Ther, 2018 Mar 06; 26(4). PMID: 29503195    Free PMC article.
Dysfunction of antigen processing and presentation by dendritic cells in cancer.
Joanna Bandola-Simon, Paul A Roche.
Mol Immunol, 2018 Apr 10; 113. PMID: 29628265    Free PMC article.
Review.
The opposing roles of CD4+ T cells in anti-tumour immunity.
Tomasz Ahrends, Jannie Borst.
Immunology, 2018 Apr 28;. PMID: 29700809    Free PMC article.
Review.
Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity.
Marte Fauskanger, Ole Audun Werner Haabeth, +2 authors, Anders Aune Tveita.
Front Immunol, 2018 Aug 08; 9. PMID: 30083157    Free PMC article.
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
Hannah M Knochelmann, Aubrey S Smith, +3 authors, Chrystal M Paulos.
Front Immunol, 2018 Aug 25; 9. PMID: 30140266    Free PMC article.
Highly Cited. Review.
Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option.
Maartje W Rohaan, Joost H van den Berg, Pia Kvistborg, John B A G Haanen.
J Immunother Cancer, 2018 Oct 05; 6(1). PMID: 30285902    Free PMC article.
Review.
Deciphering the Role of Regulatory CD4 T Cells in Oral and Oropharyngeal Cancer: A Systematic Review.
Caoimhín O'Higgins, Frank J Ward, Rasha Abu Eid.
Front Oncol, 2018 Nov 22; 8. PMID: 30460193    Free PMC article.
The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right.
Derek S Park, Mark Robertson-Tessi, +4 authors, Alexander R A Anderson.
Cancer Res, 2019 Aug 08; 79(20). PMID: 31387920    Free PMC article.
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.
Ping-Hsien Lee, Tori N Yamamoto, +11 authors, Nicholas P Restifo.
J Exp Med, 2019 Aug 14; 216(11). PMID: 31405895    Free PMC article.
Treatment effect and safety profile of salvage chemotherapy following immune checkpoint inhibitors in lung cancer.
Mari Tone, Takehiro Izumo, +6 authors, Hideo Kunitoh.
Lung Cancer Manag, 2019 Oct 28; 4(6). PMID: 31645892    Free PMC article.
Defining potency of CAR+ T cells: Fast and furious or slow and steady.
Ivan Liadi, Harjeet Singh, +3 authors, Navin Varadarajan.
Oncoimmunology, 2018 May 07; 8(10). PMID: 31646063    Free PMC article.
Immunotherapy for advanced melanoma.
Lei Fang, Anke S Lonsdorf, Sam T Hwang.
J Invest Dermatol, 2008 Oct 18; 128(11). PMID: 18927541    Free PMC article.
Review.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
Review.
High-affinity T cell receptors for adoptive cell transfer.
Ariel Isser, Jonathan P Schneck.
J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530992    Free PMC article.
Chaperone protein HSC70 regulates intercellular transfer of Y chromosome antigen DBY.
Sascha Kretschmann, Stefanie Herda, +7 authors, Anita N Kremer.
J Clin Invest, 2019 Jun 18; 129(7). PMID: 31205025    Free PMC article.
Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes.
Marcelo Sobral-Leite, Izhar Salomon, +13 authors, Marleen Kok.
Breast Cancer Res, 2019 Aug 09; 21(1). PMID: 31391067    Free PMC article.
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