. 2005 Mar; 23:23-68.
doi: 10.1146/annurev.immunol.23.021704.115839.

TNF/TNFR family members in costimulation of T cell responses

Tania H Watts 1 
  • PMID: 15771565
  •     529 citations


Several members of the tumor necrosis factor receptor (TNFR) family function after initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB (CD137), OX40 (CD134), HVEM, CD30, and GITR, all of which can have costimulatory effects on T cells. The effects of these costimulatory TNFR family members can often be functionally, temporally, or spatially segregated from those of CD28 and from each other. The sequential and transient regulation of T cell activation/survival signals by different costimulators may function to allow longevity of the response while maintaining tight control of T cell survival. Depending on the disease condition, stimulation via costimulatory TNF family members can exacerbate or ameliorate disease. Despite these complexities, stimulation or blockade of TNFR family costimulators shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity.

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Nat Rev Immunol, 2009 Mar 26; 9(4). PMID: 19319144    Free PMC article.
Highly Cited. Review.
1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Kausik Chattopadhyay, Udupi A Ramagopal, Stanley G Nathenson, Steven C Almo.
Acta Crystallogr D Biol Crystallogr, 2009 Apr 25; 65(Pt 5). PMID: 19390148    Free PMC article.
Siva-1 promotes K-48 polyubiquitination of TRAF2 and inhibits TCR-mediated activation of NF-kappaB.
Radhika Gudi, John Barkinge, +2 authors, Prasad Kanteti.
J Environ Pathol Toxicol Oncol, 2009 Apr 28; 28(1). PMID: 19392652    Free PMC article.
Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production.
Afework Kassu, Michelle D'Souza, +4 authors, Brent E Palmer.
Clin Immunol, 2009 May 02; 132(2). PMID: 19406689    Free PMC article.
Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.
Wei Jin, Xiao-Fei Zhou, +2 authors, Shao-Cong Sun.
Blood, 2009 May 05; 113(26). PMID: 19411637    Free PMC article.
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.
Daniel Hirschhorn-Cymerman, Gabrielle A Rizzuto, +6 authors, Alan N Houghton.
J Exp Med, 2009 May 06; 206(5). PMID: 19414558    Free PMC article.
Costimulatory and coinhibitory receptors in anti-tumor immunity.
Gregory Driessens, Justin Kline, Thomas F Gajewski.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426219    Free PMC article.
Sequence, structure, function, immunity: structural genomics of costimulation.
Kausik Chattopadhyay, Eszter Lazar-Molnar, +7 authors, Steven C Almo.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426233    Free PMC article.
Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors.
Rajesh K Sharma, Kutlu G Elpek, +4 authors, Haval Shirwan.
Cancer Res, 2009 May 14; 69(10). PMID: 19435920    Free PMC article.
Innate and adaptive immunity in atherosclerosis.
René R S Packard, Andrew H Lichtman, Peter Libby.
Semin Immunopathol, 2009 May 19; 31(1). PMID: 19449008    Free PMC article.
ProtEx technology for the generation of novel therapeutic cancer vaccines.
Rich-Henry Schabowsky, Rajesh K Sharma, +3 authors, Haval Shirwan.
Exp Mol Pathol, 2009 May 21; 86(3). PMID: 19454266    Free PMC article.
Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression.
Baohua Zhao, Aihua Song, +6 authors, Jianxun Song.
J Immunol, 2009 May 21; 182(11). PMID: 19454669    Free PMC article.
Hypercostimulation through 4-1BB distorts homeostasis of immune cells.
Seung-Woo Lee, Shahram Salek-Ardakani, Robert S Mittler, Michael Croft.
J Immunol, 2009 May 21; 182(11). PMID: 19454670    Free PMC article.
CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lung.
Douglas G Mack, Allison M Lanham, +2 authors, Andrew P Fontenot.
J Immunol, 2009 May 21; 182(11). PMID: 19454729    Free PMC article.
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Greta Guarda, Catherine Dostert, +5 authors, Jürg Tschopp.
Nature, 2009 Jun 06; 460(7252). PMID: 19494813
Highly Cited.
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis.
Monika Manocha, Svend Rietdijk, +7 authors, N Manjunath.
J Immunol, 2009 Jun 16; 183(1). PMID: 19525396    Free PMC article.
The role of OX40-mediated co-stimulation in T-cell activation and survival.
William L Redmond, Carl E Ruby, Andrew D Weinberg.
Crit Rev Immunol, 2009 Jun 23; 29(3). PMID: 19538134    Free PMC article.
CD28(-) T cells: their role in the age-associated decline of immune function.
Nan-Ping Weng, Arne N Akbar, Jorg Goronzy.
Trends Immunol, 2009 Jun 23; 30(7). PMID: 19540809    Free PMC article.
Highly Cited. Review.
CD4 T Cells Treated with gp120 Acquire a CD45R0+/CD45RA+ Phenotype.
Sergey A Trushin, Gary D Bren, Andrew D Badley.
Open Virol J, 2009 Jul 03; 3. PMID: 19572053    Free PMC article.
Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory.
Pujya Agarwal, Arvind Raghavan, +4 authors, Matthew F Mescher.
J Immunol, 2009 Jul 14; 183(3). PMID: 19592655    Free PMC article.
Highly Cited.
The CD8+ memory T-cell state of readiness is actively maintained and reversible.
Atef Allam, Dietrich B Conze, +5 authors, Jonathan D Ashwell.
Blood, 2009 Jul 21; 114(10). PMID: 19617575    Free PMC article.
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
K S Peggs, S A Quezada, J P Allison.
Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765    Free PMC article.
Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo.
William L Redmond, Michael J Gough, Andrew D Weinberg.
Eur J Immunol, 2009 Aug 13; 39(8). PMID: 19672905    Free PMC article.
4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies.
Syam Tammana, Xin Huang, +7 authors, Xianzheng Zhou.
Hum Gene Ther, 2009 Sep 02; 21(1). PMID: 19719389    Free PMC article.
Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL.
Jing-Hua Huang, Song-Nan Zhang, +6 authors, Chae-Ok Yun.
Mol Ther, 2009 Sep 10; 18(2). PMID: 19738604    Free PMC article.
Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration.
Young-Mi Kim, Hye Kyung Kim, +8 authors, Sik Yoon.
Exp Mol Med, 2009 Sep 12; 41(12). PMID: 19745604    Free PMC article.
Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.
Bérengère Vire, Stéphane de Walque, +3 authors, Yves Collette.
PLoS One, 2009 Sep 18; 4(9). PMID: 19759901    Free PMC article.
Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication.
Xiao-Song Zhong, Maiko Matsushita, +2 authors, Michel Sadelain.
Mol Ther, 2009 Sep 24; 18(2). PMID: 19773745    Free PMC article.
Highly Cited.
The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals.
David R Withers, Elin Jaensson, +5 authors, Peter J L Lane.
J Immunol, 2009 Sep 30; 183(8). PMID: 19786532    Free PMC article.
A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity.
Rich-Henry Schabowsky, Kutlu G Elpek, +7 authors, Haval Shirwan.
Vaccine, 2009 Oct 20; 28(2). PMID: 19836479    Free PMC article.
A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity.
Yangbing Zhao, Qiong J Wang, +7 authors, Richard A Morgan.
J Immunol, 2009 Oct 22; 183(9). PMID: 19843940    Free PMC article.
Highly Cited.
Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells.
Takayoshi Owada, Norihiko Watanabe, +7 authors, Hiroshi Nakajima.
J Leukoc Biol, 2009 Nov 07; 87(3). PMID: 19892849    Free PMC article.
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.
Javier O Valenzuela, Cristina Iclozan, +11 authors, Amer A Beg.
J Clin Invest, 2009 Nov 13; 119(12). PMID: 19907075    Free PMC article.
Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: different effects on cellular and humoral immunity.
Sumita Ganguly, Jinyan Liu, +2 authors, Rama Rao Amara.
Vaccine, 2009 Dec 01; 28(5). PMID: 19944789    Free PMC article.
CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.
Victor Peperzak, Yanling Xiao, Elise A M Veraar, Jannie Borst.
J Clin Invest, 2009 Dec 04; 120(1). PMID: 19955658    Free PMC article.
Integrating costimulatory agonists to optimize immune-based cancer therapies.
Angela D Pardee, Amy K Wesa, Walter J Storkus.
Immunotherapy, 2010 Jan 05; 1(2). PMID: 20046961    Free PMC article.
Expression and function of TNF and IL-1 receptors on human regulatory T cells.
Frances Mercer, Lina Kozhaya, Derya Unutmaz.
PLoS One, 2010 Jan 13; 5(1). PMID: 20066156    Free PMC article.
Memory CD8+ T cell differentiation.
Joshua J Obar, Leo Lefrançois.
Ann N Y Acad Sci, 2010 Feb 12; 1183. PMID: 20146720    Free PMC article.
Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival.
James I Kim, Samsher B Sonawane, +10 authors, James F Markmann.
Eur J Immunol, 2010 Feb 12; 40(5). PMID: 20148423    Free PMC article.
Enhancement of humoral and cellular immunity with an anti-glucocorticoid-induced tumour necrosis factor receptor monoclonal antibody.
Jose F Ponte, Paul Ponath, +7 authors, Michael Rosenzweig.
Immunology, 2010 Mar 06; 130(2). PMID: 20201988    Free PMC article.
Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation.
Kazue Arimoto-Miyamoto, Norimitsu Kadowaki, +3 authors, Takashi Uchiyama.
Immunology, 2010 Mar 06; 130(1). PMID: 20201989    Free PMC article.
OX40 is required for regulatory T cell-mediated control of colitis.
Thibault Griseri, Mark Asquith, Claire Thompson, Fiona Powrie.
J Exp Med, 2010 Apr 07; 207(4). PMID: 20368580    Free PMC article.
Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity.
Shahram Salek-Ardakani, Michael Croft.
J Interferon Cytokine Res, 2010 Apr 10; 30(4). PMID: 20377415    Free PMC article.
4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines.
Rajesh K Sharma, Rich-Henry Schabowsky, +8 authors, Haval Shirwan.
Cancer Res, 2010 Apr 22; 70(10). PMID: 20406989    Free PMC article.
Massively parallel pyrosequencing-based transcriptome analyses of small brown planthopper (Laodelphax striatellus), a vector insect transmitting rice stripe virus (RSV).
Fujie Zhang, Hongyan Guo, +6 authors, Xiaoying Chen.
BMC Genomics, 2010 May 14; 11. PMID: 20462456    Free PMC article.
Dendritic cell subsets as vectors and targets for improved cancer therapy.
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Curr Top Microbiol Immunol, 2010 May 22; 344. PMID: 20490776    Free PMC article.
Early events governing memory CD8+ T-cell differentiation.
Joshua J Obar, Leo Lefrançois.
Int Immunol, 2010 May 28; 22(8). PMID: 20504887    Free PMC article.
Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling.
Charles Gullo, Liang Kai Koh, +3 authors, Herbert Schwarz.
PLoS One, 2010 Jun 04; 5(5). PMID: 20520765    Free PMC article.
Plasticity in programming of effector and memory CD8 T-cell formation.
Ramon Arens, Stephen P Schoenberger.
Immunol Rev, 2010 Jun 12; 235(1). PMID: 20536564    Free PMC article.
Role of 4-1BB receptor in the control played by CD8(+) T cells on IFN-gamma production by Mycobacterium tuberculosis antigen-specific CD4(+) T Cells.
Carla Palma, Silvia Vendetti, Antonio Cassone.
PLoS One, 2010 Jun 15; 5(6). PMID: 20544034    Free PMC article.
SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model.
Rajesh K Sharma, Abhishek K Srivastava, +4 authors, Haval Shirwan.
Vaccine, 2010 Jul 07; 28(36). PMID: 20603135    Free PMC article.
Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses.
Jonathan S Kurche, Matthew A Burchill, +2 authors, Ross M Kedl.
J Immunol, 2010 Jul 20; 185(4). PMID: 20639485    Free PMC article.
Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection.
Afework Kassu, Roland A Marcus, +6 authors, Brent E Palmer.
J Immunol, 2010 Jul 27; 185(5). PMID: 20656923    Free PMC article.
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
Elizabeth D Thompson, Hilda L Enriquez, Yang-Xin Fu, Victor H Engelhard.
J Exp Med, 2010 Jul 28; 207(8). PMID: 20660615    Free PMC article.
Dendritic cells: are they clinically relevant?
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693842    Free PMC article.
Separate roles for antigen recognition and lymph node inflammation in CD8+ memory T cell formation.
Marieke F Fransen, Marianne J van Stipdonk, +3 authors, Rienk Offringa.
J Immunol, 2010 Aug 11; 185(6). PMID: 20696863    Free PMC article.
Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responses.
Ling Ni, Ingrid Gayet, +9 authors, SangKon Oh.
J Immunol, 2010 Aug 24; 185(6). PMID: 20729328    Free PMC article.
Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
Gareth W Jones, Jason S Stumhofer, +8 authors, Simon A Jones.
FASEB J, 2010 Sep 10; 25(1). PMID: 20826539    Free PMC article.
IAP inhibitors enhance co-stimulation to promote tumor immunity.
Michael Dougan, Stephanie Dougan, +11 authors, Glenn Dranoff.
J Exp Med, 2010 Sep 15; 207(10). PMID: 20837698    Free PMC article.
T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells.
Judith Leitner, Werner Kuschei, +6 authors, Peter Steinberger.
J Immunol Methods, 2010 Sep 23; 362(1-2). PMID: 20858499    Free PMC article.
Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide.
Jeremy P McAleer, Anthony T Vella.
Trends Immunol, 2010 Oct 01; 31(11). PMID: 20880743    Free PMC article.
Immunology as it pertains to drugs of abuse, AIDS and the neuroimmune axis: mediators and traffic.
Thomas J Rogers.
J Neuroimmune Pharmacol, 2010 Oct 20; 6(1). PMID: 20957520    Free PMC article.
A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment.
Angela D Pardee, Dustin McCurry, +3 authors, Walter J Storkus.
Cancer Res, 2010 Nov 04; 70(22). PMID: 21045144    Free PMC article.
CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.
Jun Wang, Wenxia Zhao, +9 authors, Shengdian Wang.
J Immunol, 2010 Nov 10; 185(12). PMID: 21059892    Free PMC article.
TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling.
Ping Xie, Zachary J Kraus, +2 authors, Gail A Bishop.
J Immunol, 2010 Nov 19; 186(1). PMID: 21084666    Free PMC article.
NKT cell costimulation: experimental progress and therapeutic promise.
Marianne J van den Heuvel, Nitan Garg, Luc Van Kaer, S M Mansour Haeryfar.
Trends Mol Med, 2010 Nov 23; 17(2). PMID: 21087900    Free PMC article.
The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs.
Shannon J Turley, Anne L Fletcher, Kutlu G Elpek.
Nat Rev Immunol, 2010 Nov 20; 10(12). PMID: 21088682
The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice.
M Galuppo, G Nocentini, +8 authors, S Cuzzocrea.
Br J Pharmacol, 2010 Nov 26; 162(5). PMID: 21091650    Free PMC article.
Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling.
Jr-Wen Shui, Marcos W Steinberg, Mitchell Kronenberg.
J Leukoc Biol, 2010 Nov 26; 89(4). PMID: 21106644    Free PMC article.
Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens.
Anik L Côté, Peisheng Zhang, +5 authors, Mary Jo Turk.
J Immunol, 2010 Nov 26; 186(1). PMID: 21106849    Free PMC article.
Dendritic cells and immunity against cancer.
K Palucka, H Ueno, J Fay, J Banchereau.
J Intern Med, 2010 Dec 17; 269(1). PMID: 21158979    Free PMC article.
Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein.
Dongsheng Jiang, Herbert Schwarz.
PLoS One, 2010 Dec 24; 5(12). PMID: 21179444    Free PMC article.
The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice.
Shahram Salek-Ardakani, Rachel Flynn, +5 authors, Michael Croft.
J Clin Invest, 2010 Dec 25; 121(1). PMID: 21183789    Free PMC article.
CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies.
Holbrook E Kohrt, Roch Houot, +11 authors, Ronald Levy.
Blood, 2011 Jan 05; 117(8). PMID: 21193697    Free PMC article.
Highly Cited.
4-1BB signaling beyond T cells.
Dass S Vinay, Byoung S Kwon.
Cell Mol Immunol, 2011 Jan 11; 8(4). PMID: 21217771    Free PMC article.
Molecular insights into γδ T cell costimulation by an anti-JAML antibody.
Petra Verdino, Deborah A Witherden, +4 authors, Ian A Wilson.
Structure, 2011 Jan 12; 19(1). PMID: 21220118    Free PMC article.
Recent developments in cancer vaccines.
Karolina Palucka, Hideki Ueno, Jacques Banchereau.
J Immunol, 2011 Jan 21; 186(3). PMID: 21248270    Free PMC article.
Regulation of mouse 4-1BB expression: multiple promoter usages and a splice variant.
Jung D Kim, Chang H Kim, Byoung S Kwon.
Mol Cells, 2011 Feb 25; 31(2). PMID: 21347708    Free PMC article.
Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function.
Jessica Ann Hernandez-Chacon, Yufeng Li, +5 authors, Laszlo G Radvanyi.
J Immunother, 2011 Mar 11; 34(3). PMID: 21389874    Free PMC article.
The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases.
D S Vinay, B S Kwon.
Clin Exp Immunol, 2011 Mar 16; 164(2). PMID: 21401577    Free PMC article.
Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations.
Pejman Soroosh, Taylor A Doherty, +7 authors, Michael Croft.
J Exp Med, 2011 Mar 16; 208(4). PMID: 21402741    Free PMC article.
Pro- and anti-apoptotic CD95 signaling in T cells.
Maren Paulsen, Ottmar Janssen.
Cell Commun Signal, 2011 Apr 12; 9. PMID: 21477291    Free PMC article.
Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro.
Jianping Huang, Qiong J Wang, +4 authors, Paul F Robbins.
J Immunother, 2011 Apr 19; 34(4). PMID: 21499130    Free PMC article.
Cell surface signaling molecules in the control of immune responses: a tide model.
Yuwen Zhu, Sheng Yao, Lieping Chen.
Immunity, 2011 Apr 23; 34(4). PMID: 21511182    Free PMC article.
Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen.
Nicola Winstone, Aaron J Wilson, +23 authors, Adrian B McDermott.
J Virol, 2011 Jul 08; 85(18). PMID: 21734035    Free PMC article.
4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection.
Vaiva Vezys, Pablo Penaloza-MacMaster, +5 authors, Rafi Ahmed.
J Immunol, 2011 Jul 12; 187(4). PMID: 21742975    Free PMC article.
CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis.
Darío A Fernández Do Porto, Javier O Jurado, +4 authors, Verónica E García.
Immunol Cell Biol, 2011 Jul 13; 90(4). PMID: 21747409    Free PMC article.
The effects of Cyclosporine A and azathioprine on human T cells activated by different costimulatory signals.
Judith Leitner, Karin Drobits, +3 authors, Peter Steinberger.
Immunol Lett, 2011 Jul 16; 140(1-2). PMID: 21756939    Free PMC article.
Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses.
Shannon E Smith, Dominique B Hoelzinger, +2 authors, Joseph Lustgarten.
Cancer Immunol Immunother, 2011 Jul 27; 60(12). PMID: 21789593    Free PMC article.
Characterization of antigenic variants of hepatitis C virus in immune evasion.
Jane H Wang, Matthew J Pianko, +6 authors, Lijun Rong.
Virol J, 2011 Aug 02; 8. PMID: 21801418    Free PMC article.
Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers.
Fernando Pastor, Despina Kolonias, James O McNamara, Eli Gilboa.
Mol Ther, 2011 Aug 11; 19(10). PMID: 21829171    Free PMC article.
The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis.
Jason P Twohig, Simone M Cuff, Audrey A Yong, Eddie C Y Wang.
Rev Neurosci, 2011 Aug 25; 22(5). PMID: 21861782    Free PMC article.
CD8(+) T cells: foot soldiers of the immune system.
Nu Zhang, Michael J Bevan.
Immunity, 2011 Aug 27; 35(2). PMID: 21867926    Free PMC article.
Highly Cited. Review.
Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory.
Jang-June Park, Sudarshan Anand, +6 authors, Koji Tamada.
Cancer Immunol Immunother, 2011 Aug 31; 61(2). PMID: 21877247    Free PMC article.
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Harry Z Qui, Adam T Hagymasi, +8 authors, Adam J Adler.
J Immunol, 2011 Sep 02; 187(7). PMID: 21880986    Free PMC article.
In vivo accumulation of T cells in response to IL-2/anti-IL-2 mAb complexes is dependent in part on the TNF family ligand 4-1BBL.
Gloria H Y Lin, John C Stone, Charles D Surh, Tania H Watts.
Immunol Cell Biol, 2011 Sep 29; 90(7). PMID: 21946662    Free PMC article.
Cell surface markers in HTLV-1 pathogenesis.
Andrea K Kress, Ralph Grassmann, Bernhard Fleckenstein.
Viruses, 2011 Oct 14; 3(8). PMID: 21994790    Free PMC article.
OX40:OX40L axis: emerging targets for improving poxvirus-based CD8(+) T-cell vaccines against respiratory viruses.
John Goulding, Vikas Tahiliani, Shahram Salek-Ardakani.
Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017437    Free PMC article.
TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation.
Françoise Meylan, Arianne C Richard, Richard M Siegel.
Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017439    Free PMC article.
NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice.
Susan E Murray, Fanny Polesso, +5 authors, David C Parker.
J Clin Invest, 2011 Nov 03; 121(12). PMID: 22045568    Free PMC article.
Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation.
Preeti Chhabra, Kenneth L Brayman.
J Transplant, 2011 Nov 03; 2011. PMID: 22046502    Free PMC article.
T-cell activation and transplantation tolerance.
Bhavana Priyadharshini, Dale L Greiner, Michael A Brehm.
Transplant Rev (Orlando), 2011 Nov 15; 26(3). PMID: 22074786    Free PMC article.
Rosacea: The cytokine and chemokine network.
Peter Arne Gerber, Bettina Alexandra Buhren, Martin Steinhoff, Bernhard Homey.
J Investig Dermatol Symp Proc, 2011 Nov 15; 15(1). PMID: 22076326    Free PMC article.
New insights on OX40 in the control of T cell immunity and immune tolerance in vivo.
Xiang Xiao, Weihua Gong, +6 authors, Xian C Li.
J Immunol, 2011 Dec 08; 188(2). PMID: 22147766    Free PMC article.
Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5.
Qing Li, Xuedong Ding, +7 authors, Roxana E Rojas.
J Leukoc Biol, 2011 Dec 14; 91(2). PMID: 22158781    Free PMC article.
An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling.
Phillip J Sanchez, Ross M Kedl.
Vaccine, 2011 Dec 20; 30(6). PMID: 22178730    Free PMC article.
Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.
Dallas B Flies, Britt J Sandler, Mario Sznol, Lieping Chen.
Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180678    Free PMC article.
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
Chao Wang, Ann J McPherson, +18 authors, Tania H Watts.
J Exp Med, 2011 Dec 21; 209(1). PMID: 22184633    Free PMC article.
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
Tao Wang, Catherine Huang, +4 authors, Russel E Kaufman.
J Leukoc Biol, 2011 Dec 21; 91(3). PMID: 22184754    Free PMC article.
Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines.
Jennifer D Bassett, Stephanie L Swift, +5 authors, Jonathan L Bramson.
Mol Ther, 2011 Dec 22; 20(4). PMID: 22186790    Free PMC article.
Upregulation of DR3 expression in CD4⁺ T cells promotes secretion of IL-17 in experimental autoimmune uveitis.
Tingyu Qin.
Mol Vis, 2012 Jan 06; 17. PMID: 22219644    Free PMC article.
The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis.
Ricardo F Antunes, Juan Carlos Kaski, Ingrid E Dumitriu.
J Biomed Biotechnol, 2012 Jan 12; 2012. PMID: 22235167    Free PMC article.
Modulation of GITR for cancer immunotherapy.
David A Schaer, Judith T Murphy, Jedd D Wolchok.
Curr Opin Immunol, 2012 Jan 17; 24(2). PMID: 22245556    Free PMC article.
Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81.
Yael Sagi, Angela Landrigan, Ronald Levy, Shoshana Levy.
Proc Natl Acad Sci U S A, 2012 Feb 07; 109(5). PMID: 22307619    Free PMC article.
CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals.
Matthew W Auten, Weitao Huang, Guixiang Dai, Alistair J Ramsay.
Vaccine, 2012 Feb 22; 30(17). PMID: 22349523    Free PMC article.
Historical overview of immunological tolerance.
Ronald H Schwartz.
Cold Spring Harb Perspect Biol, 2012 Mar 08; 4(4). PMID: 22395097    Free PMC article.
Cancer immunotherapy via dendritic cells.
Karolina Palucka, Jacques Banchereau.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871    Free PMC article.
Highly Cited. Review.
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
Anthony Joetham, Hiroshi Ohnishi, +5 authors, Erwin W Gelfand.
J Biol Chem, 2012 Mar 31; 287(21). PMID: 22461627    Free PMC article.
From genes to drugs: targeted strategies for melanoma.
Keith T Flaherty, F Stephen Hodi, David E Fisher.
Nat Rev Cancer, 2012 Apr 06; 12(5). PMID: 22475929
Highly Cited. Review.
Selective blockade of herpesvirus entry mediator-B and T lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction.
Maria-Luisa del Rio, Nick D Jones, +4 authors, Jose-Ignacio Rodriguez-Barbosa.
J Immunol, 2012 Apr 12; 188(10). PMID: 22490863    Free PMC article.
Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression.
William L Redmond, Todd Triplett, Kevin Floyd, Andrew D Weinberg.
PLoS One, 2012 Apr 13; 7(4). PMID: 22496812    Free PMC article.
Targeting costimulatory molecules to improve antitumor immunity.
Daria Capece, Daniela Verzella, +2 authors, Edoardo Alesse.
J Biomed Biotechnol, 2012 Apr 14; 2012. PMID: 22500111    Free PMC article.
CD137 deficiency does not affect development of airway inflammation or respiratory tolerance induction in murine models.
A-K Behrendt, A Meyer-Bahlburg, G Hansen.
Clin Exp Immunol, 2012 Apr 24; 168(3). PMID: 22519594    Free PMC article.
Increased plasma LIGHT levels in patients with atopic dermatitis.
H Kotani, K Masuda, +6 authors, N Katoh.
Clin Exp Immunol, 2012 Apr 24; 168(3). PMID: 22519595    Free PMC article.
CD3Z genetic polymorphism in immune response to hepatitis B vaccination in two independent Chinese populations.
Li-Ping Pan, Wei Zhang, +7 authors, Hui Li.
PLoS One, 2012 Apr 27; 7(4). PMID: 22536368    Free PMC article.
Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?
Peter J L Lane, Fabrina M Gaspal, +2 authors, Graham Anderson.
Front Immunol, 2012 May 09; 3. PMID: 22566908    Free PMC article.
Decreased expression of T-cell costimulatory molecule CD28 on CD4 and CD8 T cells of mexican patients with pulmonary tuberculosis.
German Bernal-Fernandez, Patricia Espinosa-Cueto, +2 authors, Raul Mancilla.
Tuberc Res Treat, 2010 Jan 01; 2010. PMID: 22567259    Free PMC article.
Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.
Ann J McPherson, Laura M Snell, Tak W Mak, Tania H Watts.
J Biol Chem, 2012 May 10; 287(27). PMID: 22570473    Free PMC article.
The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.
Jason P Twohig, Morgan Marsden, +6 authors, Eddie C Y Wang.
FASEB J, 2012 May 18; 26(8). PMID: 22593543    Free PMC article.
Regulation of the PKCθ-NF-κB Axis in T Lymphocytes by the Tumor Necrosis Factor Receptor Family Member OX40.
Takanori So, Michael Croft.
Front Immunol, 2012 Jun 02; 3. PMID: 22654884    Free PMC article.
Cannabinoid-like anti-inflammatory compounds from flax fiber.
Monika Styrczewska, Anna Kulma, +2 authors, Jan Szopa.
Cell Mol Biol Lett, 2012 Jun 19; 17(3). PMID: 22706678    Free PMC article.
Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients.
A J Robert McGray, Dannie Bernard, +8 authors, Jonathan L Bramson.
Oncoimmunology, 2012 Jul 04; 1(4). PMID: 22754760    Free PMC article.
Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic β-cells.
Vineeth Varanasi, Lia Avanesyan, Desiree M Schumann, Alexander V Chervonsky.
Diabetes, 2012 Jul 10; 61(11). PMID: 22773667    Free PMC article.
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions.
Sonia Feau, Zacarias Garcia, +3 authors, Stephen P Schoenberger.
Nat Commun, 2012 Jul 12; 3. PMID: 22781761    Free PMC article.
Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.
S Peter Bak, Mike Stein Barnkob, +3 authors, Jianzhu Chen.
J Immunol, 2012 Jul 17; 189(4). PMID: 22798683    Free PMC article.
OX40 signaling favors the induction of T(H)9 cells and airway inflammation.
Xiang Xiao, Savithri Balasubramanian, +7 authors, Xian Chang Li.
Nat Immunol, 2012 Jul 31; 13(10). PMID: 22842344    Free PMC article.
Highly Cited.
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
Shravan Madireddi, Rich-Henry Schabowsky, +3 authors, Haval Shirwan.
PLoS One, 2012 Aug 08; 7(8). PMID: 22870329    Free PMC article.
Nicotine up-regulated 4-1BBL expression by activating Mek-PI3K pathway augments the efficacy of bone marrow-derived dendritic cell vaccination.
Hao Jie Jin, Hua Xiu Sui, Yi Nan Wang, Feng Guang Gao.
J Clin Immunol, 2012 Aug 18; 33(1). PMID: 22898831
Mtb-specific CD27low CD4 T cells as markers of lung tissue destruction during pulmonary tuberculosis in humans.
Irina Yu Nikitina, Natalya A Kondratuk, +4 authors, Irina V Lyadova.
PLoS One, 2012 Sep 01; 7(8). PMID: 22937086    Free PMC article.
CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells.
Felix S Lichtenegger, Katharina Mueller, +4 authors, Marion Subklewe.
PLoS One, 2012 Sep 11; 7(9). PMID: 22962607    Free PMC article.
Coinhibitory molecules in autoimmune diseases.
Norihiko Watanabe, Hiroshi Nakajima.
Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525    Free PMC article.
Advances in the development of cancer immunotherapies.
Jianjun Gao, Chantale Bernatchez, +2 authors, Patrick Hwu.
Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830    Free PMC article.
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model.
Kritika Kachapati, David E Adams, +5 authors, William M Ridgway.
J Immunol, 2012 Oct 16; 189(10). PMID: 23066155    Free PMC article.
Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma.
Jie Tian, Jie Ma, +8 authors, Shengjun Wang.
PLoS One, 2012 Oct 19; 7(10). PMID: 23077535    Free PMC article.
T cell vaccinology: exploring the known unknowns.
Matt A Burchill, Beth A Tamburini, +3 authors, Ross M Kedl.
Vaccine, 2012 Nov 10; 31(2). PMID: 23137843    Free PMC article.
Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens.
Yuan Zhao, Vikas Tahiliani, Shahram Salek-Ardakani, Michael Croft.
Front Immunol, 2012 Nov 20; 3. PMID: 23162550    Free PMC article.
Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo.
Dass S Vinay, Seung J Lee, +2 authors, Byoung S Kwon.
PLoS One, 2012 Nov 28; 7(11). PMID: 23185591    Free PMC article.
SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner.
Sonia Feau, Stephen P Schoenberger, Amnon Altman, Stéphane Bécart.
J Immunol, 2012 Dec 01; 190(1). PMID: 23197258    Free PMC article.
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.
Christopher C Kloss, Maud Condomines, +2 authors, Michel Sadelain.
Nat Biotechnol, 2012 Dec 18; 31(1). PMID: 23242161    Free PMC article.
Highly Cited.
Balance between NF-κB p100 and p52 regulates T cell costimulation dependence.
Maria Letizia Giardino Torchia, Dietrich B Conze, Dragana Jankovic, Jonathan D Ashwell.
J Immunol, 2012 Dec 19; 190(2). PMID: 23248260    Free PMC article.
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.
Ivana Munitic, Mirela Kuka, +2 authors, Jonathan D Ashwell.
J Immunol, 2012 Dec 28; 190(3). PMID: 23269247    Free PMC article.
CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.
Marie-Clare St Rose, Roslyn A Taylor, +4 authors, Adam J Adler.
Immunol Cell Biol, 2013 Jan 09; 91(2). PMID: 23295363    Free PMC article.
The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses.
Isabel Barao.
Front Immunol, 2013 Jan 15; 3. PMID: 23316193    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
CD4(+) T-cell subsets in intestinal inflammation.
Matthew Shale, Chris Schiering, Fiona Powrie.
Immunol Rev, 2013 Feb 15; 252(1). PMID: 23405904    Free PMC article.
Recombinant Salmonella-based 4-1BBL vaccine enhances T cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL.
Jianxin Ye, Ling Li, +3 authors, Weichang Chen.
J Biomed Sci, 2013 Feb 19; 20. PMID: 23413971    Free PMC article.
The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy.
Amy E Moran, Magdalena Kovacsovics-Bankowski, Andrew D Weinberg.
Curr Opin Immunol, 2013 Feb 19; 25(2). PMID: 23414607    Free PMC article.
Bayesian approach to model CD137 signaling in human M. tuberculosis in vitro responses.
Darío A Fernández Do Porto, Jerónimo Auzmendi, +2 authors, Luciano Moffatt.
PLoS One, 2013 Feb 26; 8(2). PMID: 23437083    Free PMC article.
CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs.
Pablo A Romagnoli, Mary F Premenko-Lanier, Gilbert D Loria, John D Altman.
PLoS One, 2013 Feb 27; 8(2). PMID: 23441229    Free PMC article.
Agonist antibodies to TNFR molecules that costimulate T and NK cells.
Ignacio Melero, Daniel Hirschhorn-Cymerman, +2 authors, Jedd D Wolchok.
Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460535    Free PMC article.
Highly Cited.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
Adam J Adler, Anthony T Vella.
Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891    Free PMC article.
In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-versus-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor.
Kateryna Soloviova, Maksym Puliaiev, Mark Haas, Charles S Via.
J Immunol, 2013 Mar 26; 190(9). PMID: 23526821    Free PMC article.
CD137 expressed on neutrophils plays dual roles in antibacterial responses against Gram-positive and Gram-negative bacterial infections.
Quang-Tam Nguyen, Thu-Ha T Nguyen, +8 authors, Byung-Sam Kim.
Infect Immun, 2013 Apr 03; 81(6). PMID: 23545301    Free PMC article.
Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.
Yan Zheng, Yuanyuan Zha, +4 authors, Thomas F Gajewski.
Mol Immunol, 2013 Apr 04; 55(3-4). PMID: 23548837    Free PMC article.
Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.
Jessica Ann Chacon, Richard C Wu, +6 authors, Laszlo Radvanyi.
PLoS One, 2013 Apr 06; 8(4). PMID: 23560068    Free PMC article.
Immunosenescence and organ transplantation.
Timm Heinbokel, Abdallah Elkhal, +2 authors, Stefan G Tullius.
Transplant Rev (Orlando), 2013 May 04; 27(3). PMID: 23639337    Free PMC article.
CD137 is induced by the CD40 signal on chronic lymphocytic leukemia B cells and transduces the survival signal via NF-κB activation.
Yukana Nakaima, Ken Watanabe, +2 authors, Tetsuya Fukuda.
PLoS One, 2013 May 23; 8(5). PMID: 23696891    Free PMC article.
Novel antibodies targeting immune regulatory checkpoints for cancer therapy.
Chern Siang Lee, Mark Cragg, Martin Glennie, Peter Johnson.
Br J Clin Pharmacol, 2013 May 25; 76(2). PMID: 23701301    Free PMC article.
Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules.
Takanori So, Michael Croft.
Front Immunol, 2013 Jun 14; 4. PMID: 23760533    Free PMC article.
P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway.
Hanan Galski, Tamar Oved-Gelber, +3 authors, Arnon Nagler.
Biochem Pharmacol, 2013 Jun 19; 86(5). PMID: 23774624    Free PMC article.
B7-H5 costimulates human T cells via CD28H.
Yuwen Zhu, Sheng Yao, +13 authors, Lieping Chen.
Nat Commun, 2013 Jun 21; 4. PMID: 23784006    Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer.
Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer.
Front Immunol, 2013 Jun 27; 4. PMID: 23801991    Free PMC article.
Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis.
Gang Cen, Weidong Wu.
Tumour Biol, 2013 Jul 04; 34(6). PMID: 23821300
Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy.
Edwin Bremer.
ISRN Oncol, 2013 Jul 11; 2013. PMID: 23840967    Free PMC article.
Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice.
Michael E Wortzman, Gloria H Y Lin, Tania H Watts.
PLoS One, 2013 Jul 23; 8(7). PMID: 23874808    Free PMC article.
4-1BB signaling activates the t cell factor 1 effector/β-catenin pathway with delayed kinetics via ERK signaling and delayed PI3K/AKT activation to promote the proliferation of CD8+ T Cells.
Do Y Lee, Beom K Choi, +4 authors, Byoung S Kwon.
PLoS One, 2013 Jul 23; 8(7). PMID: 23874982    Free PMC article.
Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis.
Jian-yong Yu, Li Li, +4 authors, Xi-lin Song.
Tumour Biol, 2013 Aug 01; 34(6). PMID: 23900678
CD70 is downregulated by interaction with CD27.
Mirela Kuka, Ivana Munitic, Maria Letizia Giardino Torchia, Jonathan D Ashwell.
J Immunol, 2013 Aug 06; 191(5). PMID: 23913967    Free PMC article.
A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory.
Alexander M Rowe, Susan E Murray, +3 authors, David C Parker.
J Immunol, 2013 Sep 06; 191(7). PMID: 24006459    Free PMC article.
CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor.
Qunrui Ye, De-Gang Song, +5 authors, Daniel J Powell.
Clin Cancer Res, 2013 Sep 21; 20(1). PMID: 24045181    Free PMC article.
Highly Cited.
Effects of OX40-OX40L interaction on the nuclear factor of activated T cells c1 in ApoE-deficient mice.
Jin-chuan Yan, Liang-jie Xu, Cui-ping Wang, Zhong-qun Wang.
Inflammation, 2013 Sep 21; 37(1). PMID: 24045961
The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation.
Jianhui Ma, Bo-Ram Bang, +10 authors, Young Jun Kang.
Sci Signal, 2013 Oct 03; 6(295). PMID: 24084649    Free PMC article.
Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics.
Sachin Gupta, James M Termini, Saravana Kanagavelu, Geoffrey W Stone.
Immunol Res, 2013 Nov 08; 57(1-3). PMID: 24198065    Free PMC article.
CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.
Rachel Flynn, Tarun Hutchinson, +3 authors, Shahram Salek-Ardakani.
PLoS One, 2013 Nov 10; 8(10). PMID: 24205056    Free PMC article.
Iterative feature removal yields highly discriminative pathways.
Stephen O'Hara, Kun Wang, +5 authors, Michael Kirby.
BMC Genomics, 2013 Nov 28; 14. PMID: 24274115    Free PMC article.
Targeting CD137 enhances vaccine-elicited anti-respiratory syncytial virus CD8+ T cell responses in aged mice.
Sujin Lee, Robert S Mittler, Martin L Moore.
J Immunol, 2013 Nov 29; 192(1). PMID: 24285837    Free PMC article.
Continuous 4-1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy.
Jessica Ann Chacon, Shari Pilon-Thomas, Amod A Sarnaik, Laszlo G Radvanyi.
Oncoimmunology, 2013 Dec 10; 2(9). PMID: 24319633    Free PMC article.
Cognate antigen stimulation generates potent CD8(+) inflammatory effector T cells.
Hsueh-Cheng Sung, Sara Lemos, +6 authors, César Evaristo.
Front Immunol, 2014 Jan 01; 4. PMID: 24379814    Free PMC article.
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
Amit Kumar, Wasim Abbas, Georges Herbein.
Mediators Inflamm, 2014 Jan 24; 2013. PMID: 24453421    Free PMC article.
Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
Ling Yi, Yanlin Zhao, +4 authors, Hongtao Zhang.
PLoS One, 2014 Jan 28; 9(1). PMID: 24466035    Free PMC article.
TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases.
Luis M Blanco-Colio.
Front Immunol, 2014 Jan 31; 5. PMID: 24478772    Free PMC article.
4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy.
Dass S Vinay, Byoung S Kwon.
BMB Rep, 2014 Feb 07; 47(3). PMID: 24499671    Free PMC article.
Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients.
Qunrui Ye, De-Gang Song, Daniel J Powell.
Oncoimmunology, 2014 Feb 07; 2(12). PMID: 24501691    Free PMC article.
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs.
Lei Lu, Xiaobing Xu, +3 authors, Xuan Wang.
J Transl Med, 2014 Feb 08; 12. PMID: 24502656    Free PMC article.
Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.
Judith T Murphy, Andre P Burey, +4 authors, Jedd D Wolchok.
Blood, 2014 Feb 22; 123(14). PMID: 24558202    Free PMC article.
The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice.
Petra Krause, Sonja P Zahner, +3 authors, Mitchell Kronenberg.
Gastroenterology, 2014 Feb 25; 146(7). PMID: 24560868    Free PMC article.
The TNF family in T cell differentiation and function--unanswered questions and future directions.
Michael Croft.
Semin Immunol, 2014 Mar 13; 26(3). PMID: 24613728    Free PMC article.
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
Yukiko Tone, Yoko Kidani, +5 authors, Masahide Tone.
J Immunol, 2014 Mar 19; 192(8). PMID: 24634496    Free PMC article.
Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.
Pablo Penaloza-MacMaster, Jeffrey E Teigler, +7 authors, Dan H Barouch.
J Virol, 2014 Mar 22; 88(11). PMID: 24648461    Free PMC article.
Association between tumor necrosis factor-alpha gene polymorphisms and prostate cancer risk: a meta-analysis.
Liping Ma, Jiangyang Zhao, +5 authors, Shan Li.
Diagn Pathol, 2014 Mar 29; 9. PMID: 24666463    Free PMC article.
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Hiroyuki Nagashima, Yuko Okuyama, +6 authors, Takanori So.
Nat Immunol, 2014 Apr 01; 15(5). PMID: 24681564    Free PMC article.
Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity.
William L Redmond, Stefanie N Linch, Melissa J Kasiewicz.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778278    Free PMC article.
Sarcoma immunotherapy: past approaches and future directions.
S P D'Angelo, W D Tap, G K Schwartz, R D Carvajal.
Sarcoma, 2014 Apr 30; 2014. PMID: 24778572    Free PMC article.
Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells.
Anita Kumari, Ercan Cacan, Susanna F Greer, Charlie Garnett-Benson.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829753    Free PMC article.
Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata.
Marta Bertolini, Federica Zilio, +9 authors, Ralf Paus.
PLoS One, 2014 May 17; 9(5). PMID: 24832234    Free PMC article.
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy.
David A Schaer, Daniel Hirschhorn-Cymerman, Jedd D Wolchok.
J Immunother Cancer, 2014 May 24; 2. PMID: 24855562    Free PMC article.
Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.
Atef Allam, Melissa Swiecki, +2 authors, Marco Colonna.
J Immunol, 2014 Jun 11; 193(2). PMID: 24913981    Free PMC article.
p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression.
Yong Lu, Mingjun Zhang, +9 authors, Qing Yi.
Nat Commun, 2014 Jun 25; 5. PMID: 24957461    Free PMC article.
Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.
Shravan Madireddi, So-Young Eun, +7 authors, Michael Croft.
J Exp Med, 2014 Jun 25; 211(7). PMID: 24958847    Free PMC article.
Herpesvirus entry mediator (HVEM) attenuates signals mediated by the lymphotoxin β receptor (LTβR) in human cells stimulated by the shared ligand LIGHT.
John Bechill, William J Muller.
Mol Immunol, 2014 Jul 02; 62(1). PMID: 24980868    Free PMC article.
Detailed study of the interaction between human herpesvirus 6B glycoprotein complex and its cellular receptor, human CD134.
Huamin Tang, Junjie Wang, Nora F Mahmoud, Yasuko Mori.
J Virol, 2014 Jul 11; 88(18). PMID: 25008928    Free PMC article.
Human genetic evidence for involvement of CD137 in atherosclerosis.
Leif Å Söderström, Karl Gertow, +13 authors, Peder S Olofsson.
Mol Med, 2014 Jul 18; 20. PMID: 25032953    Free PMC article.
Tumour necrosis factor superfamily members in the pathogenesis of inflammatory bowel disease.
Tomasz J Ślebioda, Zbigniew Kmieć.
Mediators Inflamm, 2014 Jul 22; 2014. PMID: 25045210    Free PMC article.
JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.
Anthony Joetham, Michaela Schedel, +6 authors, Erwin W Gelfand.
J Immunol, 2014 Jul 30; 193(5). PMID: 25070841    Free PMC article.
CD137 signaling enhances tight junction resistance in intestinal epithelial cells.
Veronica Gusti, Kaila M Bennett, David D Lo.
Physiol Rep, 2014 Aug 07; 2(8). PMID: 25096552    Free PMC article.
Costimulatory molecules as vaccine adjuvants: to 4-1BB or not to 4-1BB?
Khalidur Rahman, Smita S Iyer.
Cell Mol Immunol, 2014 Sep 10; 12(4). PMID: 25195512    Free PMC article.
Therapeutic targeting of the inflammome.
Kyle T Wright, Charles Giardina, Anthony T Vella.
Biochem Pharmacol, 2014 Sep 11; 92(2). PMID: 25204592    Free PMC article.
SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines.
Abhishek K Srivastava, Gunes Dinc, +3 authors, Haval Shirwan.
Cancer Res, 2014 Sep 26; 74(22). PMID: 25252915    Free PMC article.
CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression.
Selena Viganò, Riddhima Banga, +5 authors, Matthieu Perreau.
PLoS Pathog, 2014 Sep 26; 10(9). PMID: 25255144    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system.
Dhifaf Sarhan, Padraig D'Arcy, Andreas Lundqvist.
Int J Mol Sci, 2014 Oct 16; 15(10). PMID: 25318057    Free PMC article.
Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.
Evgeniy B Eruslanov, Pratik S Bhojnagarwala, +11 authors, Sunil Singhal.
J Clin Invest, 2014 Nov 11; 124(12). PMID: 25384214    Free PMC article.
Highly Cited.
Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy.
Jessica Ann Chacon, Amod A Sarnaik, +7 authors, Laszlo Radvanyi.
Clin Cancer Res, 2014 Dec 05; 21(3). PMID: 25472998    Free PMC article.
Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects.
C Preston Neff, Jennifer L Chain, +6 authors, Andrew P Fontenot.
Am J Respir Crit Care Med, 2014 Dec 24; 191(4). PMID: 25536276    Free PMC article.
Immune checkpoint receptors in regulating immune reactivity in rheumatic disease.
Sabrina Ceeraz, Elizabeth C Nowak, Christopher M Burns, Randolph J Noelle.
Arthritis Res Ther, 2015 Jan 22; 16(5). PMID: 25606596    Free PMC article.
TNF superfamily protein-protein interactions: feasibility of small- molecule modulation.
Yun Song, Peter Buchwald.
Curr Drug Targets, 2015 Feb 24; 16(4). PMID: 25706111    Free PMC article.
Monocyte-derived dendritic cells from cirrhotic patients retain similar capacity for maturation/activation and antigen presentation as those from healthy subjects.
Shiroh Tanoue, Li-Yuan Chang, Yonghai Li, David E Kaplan.
Cell Immunol, 2015 Mar 04; 295(1). PMID: 25734547    Free PMC article.
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.
Maria Fernanda Pascutti, Sulima Geerman, +6 authors, Martijn A Nolte.
PLoS Pathog, 2015 Mar 05; 11(3). PMID: 25738498    Free PMC article.
Reducing toxicity of 4-1BB costimulation: targeting 4-1BB ligands to the tumor stroma with bi-specific aptamer conjugates.
B Schrand, A Berezhnoy, +3 authors, E Gilboa.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949891    Free PMC article.
Combinatorial Immunoprofiling in Latent Tuberculosis Infection. Toward Better Risk Stratification.
Patricio Escalante, Tobias Peikert, +10 authors, Andrew H Limper.
Am J Respir Crit Care Med, 2015 Jun 02; 192(5). PMID: 26030344    Free PMC article.
Signaling in lymphocyte activation.
Doreen Cantrell.
Cold Spring Harb Perspect Biol, 2015 Jun 03; 7(6). PMID: 26032717    Free PMC article.
Targeting signaling factors for degradation, an emerging mechanism for TRAF functions.
Xiao-Dong Yang, Shao-Cong Sun.
Immunol Rev, 2015 Jun 19; 266(1). PMID: 26085207    Free PMC article.
c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.
Maria Letizia Giardino Torchia, Ivana Munitic, +3 authors, Jonathan D Ashwell.
Eur J Immunol, 2015 Jun 23; 45(9). PMID: 26096449    Free PMC article.
The pharmacology of second-generation chimeric antigen receptors.
Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain.
Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802    Free PMC article.
Highly Cited. Review.
Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing.
Ti-Hsuan Ku, Tiantian Zhang, +4 authors, Yu-Hwa Lo.
Sensors (Basel), 2015 Jul 15; 15(7). PMID: 26153774    Free PMC article.
Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme.
Liu Yang, Geng Guo, Xiao-yuan Niu, Jing Liu.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26167495    Free PMC article.
Heterogeneous susceptibility for uraemic media calcification and concomitant inflammation within the arterial tree.
Alexander H Kirsch, Andrijana Kirsch, +13 authors, Philipp Eller.
Nephrol Dial Transplant, 2015 Jul 18; 30(12). PMID: 26185049    Free PMC article.
Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2.
Wenhai Liu, Antoine Menoret, Anthony T Vella.
Cell Mol Immunol, 2015 Jul 21; 14(3). PMID: 26189366    Free PMC article.
Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon.
Mengjie Lv, Weiwei Wu, Yuejiao Zhang, Mingzhao Zhu.
Sci Rep, 2015 Aug 08; 5. PMID: 26245828    Free PMC article.
Role of Tumor Necrosis Factor Superfamily in Neuroinflammation and Autoimmunity.
Sandip Sonar, Girdhari Lal.
Front Immunol, 2015 Aug 11; 6. PMID: 26257732    Free PMC article.
Enhancing Human Immunodeficiency Virus-Specific CD8(+) T Cell Responses with Heteroclitic Peptides.
Adeolu Oyemade Adegoke, Michael David Grant.
Front Immunol, 2015 Aug 11; 6. PMID: 26257743    Free PMC article.
TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex.
Jian-hong Shi, Shao-Cong Sun.
Mol Immunol, 2015 Aug 12; 68(2 Pt C). PMID: 26260210    Free PMC article.
Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response.
Julia Merkenschlager, George Kassiotis.
Front Immunol, 2015 Sep 01; 6. PMID: 26322045    Free PMC article.
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation.
Xiang Xiao, Xiaomin Shi, +8 authors, Xian Chang Li.
Nat Commun, 2015 Sep 15; 6. PMID: 26365427    Free PMC article.
Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.
Marie T Kim, Martin J Richer, +3 authors, John T Harty.
J Immunol, 2015 Sep 27; 195(9). PMID: 26408669    Free PMC article.
Red blood cell alloimmunization is influenced by the delay between Toll-like receptor agonist injection and transfusion.
Rahma Elayeb, Marie Tamagne, +2 authors, Benoît Vingert.
Haematologica, 2015 Oct 03; 101(2). PMID: 26430173    Free PMC article.
Synergy between CD40 and MyD88 Does Not Influence Host Survival to Salmonella Infection.
Ulf Alexander Wenzel, Maria Fernandez-Santoscoy, +2 authors, Mary Jo Wick.
Front Immunol, 2015 Oct 07; 6. PMID: 26441965    Free PMC article.
Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response.
Manisha Pathak, Pankaj Sharma, +3 authors, Shailja Misra-Bhattacharya.
Immunology, 2015 Oct 27; 147(2). PMID: 26501838    Free PMC article.
B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Responses After Transplantation.
J Marino, J T Paster, +4 authors, G Benichou.
Am J Transplant, 2015 Nov 10; 16(2). PMID: 26552037    Free PMC article.
Emerging targets in cancer immunotherapy: beyond CTLA-4 and PD-1.
Amer Assal, Justin Kaner, Gopichand Pendurti, Xingxing Zang.
Immunotherapy, 2015 Nov 17; 7(11). PMID: 26567614    Free PMC article.
Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells.
Dajana Reuter, Martin S Staege, Caspar D Kühnöl, Jürgen Föll.
Front Oncol, 2015 Nov 19; 5. PMID: 26579494    Free PMC article.
Adenoviral Vector Vaccination Induces a Conserved Program of CD8(+) T Cell Memory Differentiation in Mouse and Man.
Beatrice Bolinger, Stuart Sims, +12 authors, Paul Klenerman.
Cell Rep, 2015 Nov 21; 13(8). PMID: 26586434    Free PMC article.
Are Microglial Cells the Regulators of Lymphocyte Responses in the CNS?
Beatriz Almolda, Berta González, Bernardo Castellano.
Front Cell Neurosci, 2015 Dec 05; 9. PMID: 26635525    Free PMC article.
Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers.
I V Lyadova, A V Panteleev.
Mediators Inflamm, 2015 Dec 08; 2015. PMID: 26640327    Free PMC article.
Highly Cited. Review.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy.
Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake.
Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632    Free PMC article.
Generating Peripheral Blood Derived Lymphocytes Reacting Against Autologous Primary AML Blasts.
Rohtesh S Mehta, Xiaohua Chen, +2 authors, Paul Szabolcs.
J Immunother, 2016 Feb 06; 39(2). PMID: 26849076    Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade.
Anita Kumari, Charlie Garnett-Benson.
BMC Res Notes, 2016 Feb 14; 9. PMID: 26872462    Free PMC article.
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium.
Eileen S Kim, Jennifer E Kim, +3 authors, Michael Lim.
J Immunol Res, 2016 Feb 18; 2016. PMID: 26881264    Free PMC article.
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia.
Taizou Hirano, Toshiaki Kikuchi, +12 authors, Masakazu Ichinose.
EMBO Mol Med, 2016 Mar 16; 8(4). PMID: 26976612    Free PMC article.
4-1BB agonism: adding the accelerator to cancer immunotherapy.
Cariad Chester, Siddhant Ambulkar, Holbrook E Kohrt.
Cancer Immunol Immunother, 2016 Apr 02; 65(10). PMID: 27034234    Free PMC article.
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease.
John Attanasio, E John Wherry.
Immunity, 2016 May 19; 44(5). PMID: 27192569    Free PMC article.
Highly Cited. Review.
Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression.
Emily R Mercadante, Ulrike M Lorenz.
Front Immunol, 2016 Jun 01; 7. PMID: 27242798    Free PMC article.
The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways.
Xiang Xiao, Xiaomin Shi, +7 authors, Xian Chang Li.
Immunity, 2016 Jun 19; 44(6). PMID: 27317259    Free PMC article.
B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity.
Federica Piancone, Marina Saresella, +8 authors, Mario Clerici.
Sci Rep, 2016 Jul 15; 6. PMID: 27412504    Free PMC article.
Combinatorial immunotherapeutic approaches to restore the function of anergic tumor-reactive cytotoxic CD8+ T cells.
William L Redmond, Stefanie N Linch.
Hum Vaccin Immunother, 2016 Jul 28; 12(10). PMID: 27459422    Free PMC article.
Enhanced Requirement for TNFR2 in Graft Rejection Mediated by Low-Affinity Memory CD8+ T Cells during Heterologous Immunity.
Scott M Krummey, Ching-Wen Chen, +4 authors, Mandy L Ford.
J Immunol, 2016 Aug 03; 197(5). PMID: 27481849    Free PMC article.
Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma.
Blanca Homet Moreno, Stephen Mok, +2 authors, Antoni Ribas.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622011    Free PMC article.
Molecular pathways driving disease-specific alterations of intestinal epithelial cells.
Rocío López-Posadas, Markus F Neurath, Imke Atreya.
Cell Mol Life Sci, 2016 Sep 15; 74(5). PMID: 27624395
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Geoffrey S Williams, Bina Mistry, +20 authors, Robert W Wilkinson.
Oncotarget, 2016 Sep 15; 7(42). PMID: 27626702    Free PMC article.
Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma.
Shiro Kimbara, Shunsuke Kondo.
World J Gastroenterol, 2016 Sep 28; 22(33). PMID: 27672267    Free PMC article.
Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice.
Chao Li, Sitong Du, +5 authors, Jie Chen.
Theranostics, 2016 Oct 05; 6(12). PMID: 27698940    Free PMC article.
Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.
Jeffrey J Teoh, Awndre E Gamache, +4 authors, Michael G Brown.
J Immunol, 2016 Nov 01; 197(11). PMID: 27798162    Free PMC article.
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.
Randy F Sweis, Matthew D Galsky.
Urol Oncol, 2016 Nov 12; 34(12). PMID: 27836246    Free PMC article.
Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis.
Elisa Petruccioli, Thomas J Scriba, +6 authors, Delia Goletti.
Eur Respir J, 2016 Nov 12; 48(6). PMID: 27836953    Free PMC article.
Highly Cited. Review.
Effect of cyclosporin A intervention on the immunological mechanisms of coronary heart disease and restenosis.
Xuan Wang, Yue-Cheng Hu, +4 authors, Hong-Liang Cong.
Exp Ther Med, 2016 Nov 25; 12(5). PMID: 27882144    Free PMC article.
TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology.
Françoise Meylan, Richard M Siegel.
Semin Immunopathol, 2016 Nov 30; 39(1). PMID: 27896636    Free PMC article.
Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy.
Adam J Adler, Payal Mittal, +3 authors, Anthony T Vella.
Immunotherapy, 2016 Dec 22; 9(1). PMID: 28000531    Free PMC article.
Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.
Kazushi Izawa, Emmanuel Martin, +13 authors, Sylvain Latour.
J Exp Med, 2016 Dec 25; 214(1). PMID: 28011863    Free PMC article.
New Immunotherapy Strategies in Breast Cancer.
Lin-Yu Yu, Jie Tang, +4 authors, Xiao-Ping Chen.
Int J Environ Res Public Health, 2017 Jan 14; 14(1). PMID: 28085094    Free PMC article.
Tumor Necrosis Factor-α T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis.
Ping Wang, June Wang, Mingxia Yu, Zhiqiang Li.
Dis Markers, 2017 Jan 25; 2016. PMID: 28115787    Free PMC article.
Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy.
Roberta Aliperta, Petra B Welzel, +14 authors, Michael P Bachmann.
Sci Rep, 2017 Feb 17; 7. PMID: 28205621    Free PMC article.
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases.
Michael Croft, Richard M Siegel.
Nat Rev Rheumatol, 2017 Mar 10; 13(4). PMID: 28275260    Free PMC article.
Highly Cited. Review.
Amelioration of Inflammatory Cytokines Mix Stimulation: A Pretreatment of CD137 Signaling Study on VSMC.
Wei Zhong, Bo Li, +5 authors, Jin Chuan Yan.
Mediators Inflamm, 2017 Mar 11; 2017. PMID: 28280290    Free PMC article.
Phenotype and function of tumor-associated neutrophils and their subsets in early-stage human lung cancer.
Evgeniy B Eruslanov.
Cancer Immunol Immunother, 2017 Mar 12; 66(8). PMID: 28283697    Free PMC article.
OX40 signaling is involved in the autoactivation of CD4+CD28- T cells and contributes to the pathogenesis of autoimmune arthritis.
Juean Jiang, Cuiping Liu, +7 authors, Xueguang Zhang.
Arthritis Res Ther, 2017 Mar 23; 19(1). PMID: 28320444    Free PMC article.
Aptamers for CD Antigens: From Cell Profiling to Activity Modulation.
Amin Nozari, Maxim V Berezovski.
Mol Ther Nucleic Acids, 2017 Mar 23; 6. PMID: 28325295    Free PMC article.
CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice.
Matthew H Forsberg, Ashley E Ciecko, +4 authors, Yi-Guang Chen.
J Immunol, 2017 Apr 02; 198(10). PMID: 28363905    Free PMC article.
Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm.
Aakanksha Jain, Chandrashekhar Pasare.
J Immunol, 2017 May 10; 198(10). PMID: 28483987    Free PMC article.
Highly Cited. Review.
Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation.
Xiaojun Liu, Shuguang Jiang, +5 authors, Yangbing Zhao.
Protein Cell, 2017 May 20; 8(7). PMID: 28523432    Free PMC article.
Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.
Nicholas D Leigh, Rachel E O'Neill, +6 authors, Xuefang Cao.
J Immunol, 2017 May 28; 199(1). PMID: 28550198    Free PMC article.
Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives.
Clizia Zichi, Marcello Tucci, +5 authors, Massimo Di Maio.
Biomed Res Int, 2017 Jul 07; 2017. PMID: 28680882    Free PMC article.
Novel CD137 Gene Polymorphisms and Susceptibility to Ischemic Stroke in the Northern Chinese Han Population.
Shuang Zhang, Zongmin Li, +9 authors, Jiawei Tian.
Neuromolecular Med, 2017 Jul 30; 19(2-3). PMID: 28755037
Enhanced immune-modulatory effects of thalidomide and dexamethasone co-treatment on T cell subsets.
Eun Jee Kim, Jae Geun Lee, +6 authors, Yu Seun Kim.
Immunology, 2017 Aug 02; 152(4). PMID: 28758197    Free PMC article.
Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy.
Rajeev Shrimali, Shamim Ahmad, +7 authors, Samir N Khleif.
J Immunother Cancer, 2017 Aug 16; 5(1). PMID: 28807056    Free PMC article.
HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity.
Pritesh Desai, Georges Abboud, +5 authors, Shahram Salek-Ardakani.
J Immunol, 2017 Sep 03; 199(8). PMID: 28864473    Free PMC article.
CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice.
Angela C Zhou, Laura M Snell, Michael E Wortzman, Tania H Watts.
Front Immunol, 2017 Oct 11; 8. PMID: 28993768    Free PMC article.
T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.
Rachel E O'Neill, Wei Du, +6 authors, Xuefang Cao.
J Immunol, 2017 Oct 20; 199(10). PMID: 29046346    Free PMC article.
Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.
Tamson Moore, Courtney Regan Wagner, +23 authors, Michael I Nishimura.
Cancer Immunol Immunother, 2017 Oct 21; 67(2). PMID: 29052782    Free PMC article.
Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies.
Maksim Mamonkin, Malini Mukherjee, +6 authors, Malcolm K Brenner.
Cancer Immunol Res, 2017 Oct 29; 6(1). PMID: 29079655    Free PMC article.
Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins.
M Speir, A Authier-Hall, +11 authors, R Weinkove.
Sci Rep, 2017 Oct 29; 7(1). PMID: 29079845    Free PMC article.
Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
Aruna Bitra, Tzanko Doukov, +4 authors, Dirk M Zajonc.
J Biol Chem, 2017 Dec 16; 293(4). PMID: 29242193    Free PMC article.
Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma.
Zhiying Shao, Andrew Z Wang, Daniel J George, Tian Zhang.
Asian J Urol, 2016 Oct 01; 3(4). PMID: 29264195    Free PMC article.
Associations between TNFSF4, TNFSF8 and TNFSF15 and Behçet's disease but not VKH syndrome in Han Chinese.
Yan Jiang, Ling Cheng, +2 authors, Li Zhang.
Oncotarget, 2017 Dec 30; 8(62). PMID: 29285231    Free PMC article.
Identification of key genes implicated in the suppressive function of human FOXP3+CD25+CD4+ regulatory T cells through the analysis of time‑series data.
Xiaofeng Bai, Hua Shi, +3 authors, Shuxiong Xu.
Mol Med Rep, 2017 Dec 30; 17(3). PMID: 29286140    Free PMC article.
Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma.
Reid W Merryman, Philippe Armand, Kyle T Wright, Scott J Rodig.
Blood Adv, 2018 Jan 04; 1(26). PMID: 29296917    Free PMC article.
Highly Cited. Review.
Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses.
Il-Kyu Choi, Zhe Wang, +10 authors, Baochun Zhang.
Proc Natl Acad Sci U S A, 2018 Jan 10; 115(4). PMID: 29311309    Free PMC article.
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.
Eleni Panagioti, Paul Klenerman, +2 authors, Ramon Arens.
Front Immunol, 2018 Mar 06; 9. PMID: 29503649    Free PMC article.
CD30 expression and survival in extranodal NK/T-cell lymphoma: a systematic review and meta-analysis.
Zihang Chen, Pujun Guan, +8 authors, Weiping Liu.
Oncotarget, 2018 Apr 18; 9(23). PMID: 29662666    Free PMC article.
The promise and challenges of immune agonist antibody development in cancer.
Patrick A Mayes, Kenneth W Hance, Axel Hoos.
Nat Rev Drug Discov, 2018 Jun 16; 17(7). PMID: 29904196
Highly Cited. Review.
The application of CAR-T cell therapy in hematological malignancies: advantages and challenges.
Zijun Zhao, Yu Chen, +2 authors, Minhao Wu.
Acta Pharm Sin B, 2018 Aug 16; 8(4). PMID: 30109179    Free PMC article.
Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways.
Jian-Hong Shi, Shao-Cong Sun.
Front Immunol, 2018 Aug 25; 9. PMID: 30140268    Free PMC article.
Highly Cited. Review.
Targeting immune checkpoints in melanoma: an update.
Rodrigo R Munhoz, Alejandro Falcón González, Vanessa A Reed, Michael A Postow.
Melanoma Manag, 2015 Nov 01; 2(4). PMID: 30190862    Free PMC article.
Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4+ T Cells.
Hiroyuki Nagashima, Naoto Ishii, Takanori So.
Front Immunol, 2018 Sep 15; 9. PMID: 30214449    Free PMC article.
4-1BB enhancement of CAR T function requires NF-κB and TRAFs.
Gongbo Li, Justin C Boucher, +8 authors, Marco L Davila.
JCI Insight, 2018 Sep 21; 3(18). PMID: 30232281    Free PMC article.
A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity.
Meinolf Thiemann, David M Richards, +10 authors, Oliver Hill.
Front Oncol, 2018 Oct 10; 8. PMID: 30298117    Free PMC article.
The Role of Co-Stimulatory Molecules in Chagas Disease.
Bruna F Pinto, Nayara I Medeiros, +4 authors, Juliana A S Gomes.
Cells, 2018 Nov 09; 7(11). PMID: 30405039    Free PMC article.
Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression.
Benjamin J Schmiedel, Divya Singh, +12 authors, Pandurangan Vijayanand.
Cell, 2018 Nov 20; 175(6). PMID: 30449622    Free PMC article.
Highly Cited.
Crosstalk Between PD-1/PD-L1 Blockade and Its Combinatorial Therapies in Tumor Immune Microenvironment: A Focus on HNSCC.
Weimin Lin, Miao Chen, +2 authors, Qianming Chen.
Front Oncol, 2018 Dec 07; 8. PMID: 30519541    Free PMC article.
The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus.
Anselm Mak, Herbert Schwarz.
Cells, 2019 Sep 11; 8(9). PMID: 31500130    Free PMC article.
Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells.
Rémy Rodriguez, Benjamin Fournier, +14 authors, Sylvain Latour.
J Exp Med, 2019 Sep 21; 216(12). PMID: 31537641    Free PMC article.
ILC2 Activation by Protozoan Commensal Microbes.
Kyle Burrows, Louis Ngai, +2 authors, Arthur Mortha.
Int J Mol Sci, 2019 Oct 03; 20(19). PMID: 31574995    Free PMC article.
GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory.
Yisel Rivera-Molina, Hong Jiang, +9 authors, Candelaria Gomez-Manzano.
Neurooncol Adv, 2019 Oct 15; 1(1). PMID: 31608328    Free PMC article.
Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells.
Kamila Hladíková, Vladimír Koucký, +12 authors, Anna Fialová.
J Immunother Cancer, 2019 Oct 19; 7(1). PMID: 31623665    Free PMC article.
The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma.
Peng Liao, Haofan Wang, +2 authors, Xin-Hua Liang.
Front Immunol, 2019 Nov 12; 10. PMID: 31708918    Free PMC article.
Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice.
Matthias Mulazzani, Simon P Fräßle, +14 authors, Louisa von Baumgarten.
Proc Natl Acad Sci U S A, 2019 Nov 13; 116(48). PMID: 31712432    Free PMC article.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
Comprehensive analysis of tumor necrosis factor receptor TNFRSF9 (4-1BB) DNA methylation with regard to molecular and clinicopathological features, immune infiltrates, and response prediction to immunotherapy in melanoma.
Anne Fröhlich, Sophia Loick, +13 authors, Dimo Dietrich.
EBioMedicine, 2020 Feb 07; 52. PMID: 32028068    Free PMC article.
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma.
Megumi Goto, Kenji Chamoto, +17 authors, Tasuku Honjo.
Sci Rep, 2019 Jul 14; 9(1). PMID: 31300681    Free PMC article.
A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors.
Anna Konstorum, Anthony T Vella, Adam J Adler, Reinhard C Laubenbacher.
Sci Rep, 2019 Jul 28; 9(1). PMID: 31350431    Free PMC article.
Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn's Disease.
Ludovica F Buttó, Li-Guo Jia, +7 authors, Fabio Cominelli.
Inflamm Bowel Dis, 2018 Oct 09; 25(1). PMID: 30295722    Free PMC article.
Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
Carter M Suryadevara, Rupen Desai, +12 authors, Luis Sanchez-Perez.
Clin Cancer Res, 2018 Nov 15; 25(1). PMID: 30425092    Free PMC article.
Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses.
Céline Cousin, Marine Oberkampf, +8 authors, Claude Leclerc.
Cell Rep, 2019 Jan 31; 26(5). PMID: 30699352    Free PMC article.
Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Liqiang Pan, Tian-Min Fu, +10 authors, James J Chou.
Cell, 2019 Mar 05; 176(6). PMID: 30827683    Free PMC article.
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An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE).
Derek L Clouthier, Scott C Lien, +30 authors, Lillian L Siu.
J Immunother Cancer, 2019 Mar 15; 7(1). PMID: 30867072    Free PMC article.
Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity.
Xinyue Qi, Fanlin Li, +4 authors, Xuanming Yang.
Nat Commun, 2019 May 21; 10(1). PMID: 31105267    Free PMC article.
Concepts for agonistic targeting of CD40 in immuno-oncology.
David M Richards, Julian P Sefrin, +2 authors, Christian Merz.
Hum Vaccin Immunother, 2019 Aug 14; 16(2). PMID: 31403344    Free PMC article.
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E L Wissinger, J Saldana, A Didierlaurent, T Hussell.
Mucosal Immunol, 2008 Dec 17; 1(4). PMID: 19079188    Free PMC article.
CD27 Promotes CD4+ Effector T Cell Survival in Response to Tissue Self-Antigen.
Kelly A Remedios, Lauren Meyer, +4 authors, Michael D Rosenblum.
J Immunol, 2019 Jun 19; 203(3). PMID: 31209102    Free PMC article.
Targeting the 4-1BB costimulatory molecule through single chain antibodies promotes the human T-cell response.
Salman Bagheri, Elmira Safaie Qamsari, +2 authors, Zahra Sharifzadeh.
Cell Mol Biol Lett, 2020 Apr 28; 25. PMID: 32336974    Free PMC article.
Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency.
Mohammed F Alosaimi, Manfred Hoenig, +17 authors, Raif S Geha.
J Allergy Clin Immunol, 2019 Mar 16; 144(2). PMID: 30872117    Free PMC article.
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality.
David M Richards, Viola Marschall, +10 authors, Meinolf Thiemann.
J Immunother Cancer, 2019 Jul 22; 7(1). PMID: 31324216    Free PMC article.
Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia.
Siyu Gu, Jie Zi, +2 authors, Zheng Ge.
Cancer Cell Int, 2020 May 12; 20. PMID: 32390761    Free PMC article.
Th9 Cell Differentiation and Its Dual Effects in Tumor Development.
Tao Chen, Jufeng Guo, +10 authors, Zhaoming Ye.
Front Immunol, 2020 Jun 09; 11. PMID: 32508847    Free PMC article.
Chimeric antigen receptor signaling: Functional consequences and design implications.
S E Lindner, S M Johnson, C E Brown, L D Wang.
Sci Adv, 2020 Jul 09; 6(21). PMID: 32637585    Free PMC article.
Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues.
Dominika W Gajdasik, Fabrina Gaspal, +11 authors, David R Withers.
Nat Commun, 2020 Jul 11; 11(1). PMID: 32647184    Free PMC article.
Integrate Molecular Phenome and Polygenic Interaction to Detect the Genetic Risk of Ischemic Stroke.
Xiaoying Li, Weilin Shi, +7 authors, Litao Sun.
Front Cell Dev Biol, 2020 Jul 17; 8. PMID: 32671063    Free PMC article.
Design and Production of Newcastle Disease Virus for Intratumoral Immunomodulation.
Gayathri Vijayakumar, Dmitriy Zamarin.
Methods Mol Biol, 2019 Sep 06; 2058. PMID: 31486036    Free PMC article.
MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals.
Melissa Stunnenberg, Lisa van Pul, +4 authors, Neeltje A Kootstra.
Viruses, 2020 Jul 28; 12(7). PMID: 32708557    Free PMC article.
The Ways of Isolating Neoantigen-Specific T Cells.
Qing Li, Zhen-Yu Ding.
Front Oncol, 2020 Aug 28; 10. PMID: 32850430    Free PMC article.
T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect.
Meng Zhou, Faruk Sacirbegovic, +2 authors, Warren D Shlomchik.
Nat Commun, 2020 Aug 26; 11(1). PMID: 32839441    Free PMC article.
Contrasting effects of B cell depletion on CD4+ and CD8+ memory T cell responses generated after transplantation.
Jose Marino, Bruno Gonzalez-Nolasco, +2 authors, Gilles Benichou.
Am J Transplant, 2020 Mar 19; 20(9). PMID: 32185859    Free PMC article.
A DNA Vaccine Encoding SA-4-1BBL Fused to HPV-16 E7 Antigen Has Prophylactic and Therapeutic Efficacy in a Cervical Cancer Mouse Model.
Rodolfo Garza-Morales, Jose J Perez-Trujillo, +8 authors, Roberto Montes-de-Oca-Luna.
Cancers (Basel), 2019 Jan 18; 11(1). PMID: 30650588    Free PMC article.
Engineering and Design of Chimeric Antigen Receptors.
Sonia Guedan, Hugo Calderon, Avery D Posey, Marcela V Maus.
Mol Ther Methods Clin Dev, 2019 Jan 23; 12. PMID: 30666307    Free PMC article.
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Assessment of the presence and anti-tumor potential of tumor-infiltrating lymphocytes in patients with acute myeloid leukemia.
Liya Wei, Zhenkun Wang, +10 authors, Jin Zhou.
Cancer Manag Res, 2019 May 23; 11. PMID: 31114360    Free PMC article.
OX40 and OX40L protein expression of tumor infiltrating lymphocytes in non-small cell lung cancer and its role in clinical outcome and relationships with other immune biomarkers.
Yayi He, Xiaoshen Zhang, +6 authors, Caicun Zhou.
Transl Lung Cancer Res, 2019 Sep 27; 8(4). PMID: 31555511    Free PMC article.
TNF-a Is a Potent Stimulator of Tc9-Cell Differentiation.
Siyu Yang, Jintong Chen, +5 authors, Siqing Wang.
J Immunother, 2020 Aug 26; 43(9). PMID: 32842039    Free PMC article.
Emerging Targets of Immunotherapy in Gynecologic Cancer.
Hongyan Cheng, Liju Zong, +3 authors, Yang Xiang.
Onco Targets Ther, 2020 Nov 27; 13. PMID: 33239889    Free PMC article.
Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.
Maria Parkhurst, Alena Gros, +4 authors, Steven A Rosenberg.
Clin Cancer Res, 2016 Nov 09; 23(10). PMID: 27827318    Free PMC article.
Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells.
Sze-Ling Ng, Ester Leno-Duran, +2 authors, Jack L Strominger.
Proc Natl Acad Sci U S A, 2019 Jan 27; 116(7). PMID: 30683721    Free PMC article.
Polyphenol Effects on Splenic Cytokine Response in Post-Weaning Contactin 1-Overexpressing Transgenic Mice.
Thea Magrone, Anna Spagnoletta, +3 authors, Gianfranco Gennarini.
Molecules, 2019 Jun 20; 24(12). PMID: 31212848    Free PMC article.
SNHG6 Interacted with miR-325-3p to Regulate Cisplatin Resistance of Gastric Cancer by Targeting GITR.
Tuanhe Sun, Kang Li, +3 authors, Dawei Yuan.
Onco Targets Ther, 2020 Dec 04; 13. PMID: 33268996    Free PMC article.
4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells.
Qiang Dai, Ping Han, +6 authors, Xuanming Yang.
Front Immunol, 2020 Dec 08; 11. PMID: 33281809    Free PMC article.
Primary immune regulatory disorders: a growing universe of immune dysregulation.
Alice Y Chan, Troy R Torgerson.
Curr Opin Allergy Clin Immunol, 2020 Sep 18; 20(6). PMID: 32941318    Free PMC article.
Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors.
Yu Zhang, Xin-Yuan Guan, Peng Jiang.
Front Immunol, 2021 Jan 01; 11. PMID: 33381115    Free PMC article.
Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia.
Xiao-Qing Li, Yang-Yang Wang, +7 authors, Guang-Zhi Liu.
Cell Mol Neurobiol, 2019 Feb 20; 39(3). PMID: 30778712
CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.
Cheng Ye, Benjamin E Low, +3 authors, John P Driver.
J Immunol, 2020 Sep 02; 205(7). PMID: 32868408    Free PMC article.
Engineered off-the-shelf therapeutic T cells resist host immune rejection.
Feiyan Mo, Norihiro Watanabe, +11 authors, Maksim Mamonkin.
Nat Biotechnol, 2020 Jul 15; 39(1). PMID: 32661440    Free PMC article.
Targeting ubiquitin signaling for cancer immunotherapy.
Xiaofei Zhou, Shao-Cong Sun.
Signal Transduct Target Ther, 2021 Jan 14; 6(1). PMID: 33436547    Free PMC article.
Development of CAR-T Cell Persistence in Adoptive Immunotherapy of Solid Tumors.
Jiaqiao Fan, Jugal Kishore Das, +2 authors, Jianxun Song.
Front Oncol, 2021 Jan 26; 10. PMID: 33489881    Free PMC article.
Selective BET-bromodomain inhibition by JQ1 suppresses dendritic cell maturation and antigen-specific T-cell responses.
Niklas Remke, Savita Bisht, +2 authors, Peter Brossart.
Cancer Immunol Immunother, 2020 Jul 12; 70(1). PMID: 32651619
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Piotr Bielecki, Samantha J Riesenfeld, +29 authors, Richard A Flavell.
Nature, 2021 Feb 05; 592(7852). PMID: 33536623    Free PMC article.
Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.
Elsa Du Bruyn, Sheena Ruzive, +5 authors, Catherine Riou.
Mucosal Immunol, 2020 Jul 18; 14(2). PMID: 32678272    Free PMC article.
CD137+ T-Cells: Protagonists of the Immunotherapy Revolution.
Alessio Ugolini, Marianna Nuti.
Cancers (Basel), 2021 Feb 04; 13(3). PMID: 33530328    Free PMC article.
GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation.
Yaping Wang, Kou Liao, +13 authors, Fengxia Ding.
Respir Res, 2021 Feb 10; 22(1). PMID: 33557842    Free PMC article.
Cytokines frequently implicated in myeloproliferative neoplasms.
Yingying Wang, Xuelan Zuo.
Cytokine X, 2019 Mar 27; 1(1). PMID: 33604548    Free PMC article.
Taking T-Cell Oncotherapy Off-the-Shelf.
Feiyan Mo, Maksim Mamonkin, Malcolm K Brenner, Helen E Heslop.
Trends Immunol, 2021 Feb 05; 42(3). PMID: 33536140    Free PMC article.
Altered CSF Albumin Quotient Links Peripheral Inflammation and Brain Damage in MS.
Marco Puthenparampil, Paula Tomas-Ojer, +8 authors, Mireia Sospedra.
Neurol Neuroimmunol Neuroinflamm, 2021 Mar 03; 8(2). PMID: 33649179    Free PMC article.
Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B.
Meng-Ru Zhan, Xiu-Zhu Gao, +4 authors, Jun-Qi Niu.
World J Clin Cases, 2021 Mar 18; 9(7). PMID: 33728305    Free PMC article.
Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Feng Wang, Bryant Chau, +10 authors, Pavel Strop.
Nat Commun, 2021 Mar 04; 12(1). PMID: 33654081    Free PMC article.
Critical Roles of Balanced T Helper 9 Cells and Regulatory T Cells in Allergic Airway Inflammation and Tumor Immunity.
Muhua Huang, Jingcheng Dong.
J Immunol Res, 2021 Mar 23; 2021. PMID: 33748292    Free PMC article.
OX40L/OX40 Signal Promotes IL-9 Production by Mucosal MAIT Cells During Helicobacter pylori Infection.
Siqi Ming, Mei Zhang, +10 authors, Yongjian Wu.
Front Immunol, 2021 Mar 30; 12. PMID: 33777009    Free PMC article.
Flow Cytometric Characterization of Human Antigen-Reactive T-Helper Cells.
Carina Saggau, Alexander Scheffold, Petra Bacher.
Methods Mol Biol, 2021 May 01; 2285. PMID: 33928550
Depleting Tumor Cells Expressing Immune Checkpoint Ligands-A New Approach to Combat Cancer.
Fabrizio Marcucci, Cristiano Rumio.
Cells, 2021 May 01; 10(4). PMID: 33921301    Free PMC article.
CD137: A Member of the TNFR Family - in Psoriasis Skin Lesions in Comparison with Normal Skin Specimens.
Parvin Rajabi Dehnavi, Seyyed Mehdi Eftekhari, Azadeh Kadkhodaei, Amirhosein Kefayat.
Iran J Pathol, 2021 May 04; 16(2). PMID: 33936220    Free PMC article.
The Combination of gQ1 and gQ2 in Human Herpesvirus 6A and 6B Regulates the Viral Tetramer Function for Their Receptor Recognition.
Aika Wakata, Lidya Handayani Tjan, +5 authors, Yasuko Mori.
J Virol, 2020 Dec 11;. PMID: 33298543    Free PMC article.
Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells.
Yiwei Zhang, Zhiyuan Wei, +6 authors, Yi Tian.
RNA Biol, 2020 Dec 12; 18(5). PMID: 33302787    Free PMC article.
Genome wide DNA methylation landscape reveals glioblastoma's influence on epigenetic changes in tumor infiltrating CD4+ T cells.
Marpe Bam, Sreenivasulu Chintala, +8 authors, Mahua Dey.
Oncotarget, 2021 May 21; 12(10). PMID: 34012510    Free PMC article.
Stay on Target: Reengaging Cancer Vaccines in Combination Immunotherapy.
Benjamin Wolfson, S Elizabeth Franks, James W Hodge.
Vaccines (Basel), 2021 Jun 03; 9(5). PMID: 34063388    Free PMC article.
OX40L-OX40 Signaling in Atopic Dermatitis.
Masutaka Furue, Mihoko Furue.
J Clin Med, 2021 Jul 03; 10(12). PMID: 34208041    Free PMC article.
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage.
Jonathan B Johnnidis, Yuki Muroyama, +25 authors, E John Wherry.
Sci Immunol, 2021 Jan 17; 6(55). PMID: 33452106    Free PMC article.
OX40 agonist combined with irreversible electroporation synergistically eradicates established tumors and drives systemic antitumor immune response in a syngeneic pancreatic cancer model.
Qi-Wei Zhang, Xiao-Xia Guo, +4 authors, Xiao-Yi Ding.
Am J Cancer Res, 2021 Jul 13; 11(6). PMID: 34249428    Free PMC article.
Double-edged effects of interferons on the regulation of cancer-immunity cycle.
Xiao Zhang, Song Wang, +5 authors, Xiaobo Li.
Oncoimmunology, 2021 Jul 16; 10(1). PMID: 34262796    Free PMC article.
CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models.
Montserrat Puigdelloses, Marc Garcia-Moure, +17 authors, Marta Alonso.
J Immunother Cancer, 2021 Jul 21; 9(7). PMID: 34281988    Free PMC article.
Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.
Hanzeng Li, Bruce S Hostager, Tina Arkee, Gail A Bishop.
J Biol Chem, 2021 Aug 22; 297(3). PMID: 34418432    Free PMC article.
Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective.
Jeremy Baldwin, Sakshi Piplani, +3 authors, Nikolai Petrovsky.
Bioanalysis, 2021 Oct 15; 13(24). PMID: 34645288    Free PMC article.
Advances in Universal CAR-T Cell Therapy.
Haolong Lin, Jiali Cheng, +2 authors, Li Zhu.
Front Immunol, 2021 Oct 26; 12. PMID: 34691052    Free PMC article.
IL-15 Trans-Presentation Is an Autonomous, Antigen-Independent Process.
Ádám Kenesei, Julianna Volkó, +7 authors, György Vámosi.
J Immunol, 2021 Oct 17; 207(10). PMID: 34654688    Free PMC article.
Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity.
Yunqian Qiao, Yangmin Qiu, +15 authors, Xuan Wang.
Nat Commun, 2021 Nov 06; 12(1). PMID: 34737267    Free PMC article.
T cell receptor-targeted immunotherapeutics drive selective in vivo HIV- and CMV-specific T cell expansion in humanized mice.
Mengyan Li, Scott J Garforth, +9 authors, Harris Goldstein.
J Clin Invest, 2021 Oct 22; 131(23). PMID: 34673568    Free PMC article.
Tumor Necrosis Factor Family Member Profile Predicts Prognosis and Adjuvant Chemotherapy Benefit for Patients With Small-Cell Lung Cancer.
Zhihui Zhang, Peng Wu, +7 authors, Jie He.
Front Immunol, 2021 Dec 07; 12. PMID: 34867972    Free PMC article.
Quantitative contributions of TNF receptor superfamily members to CD8+ T-cell responses.
John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek.
Mol Syst Biol, 2021 Nov 23; 17(11). PMID: 34806839    Free PMC article.
Immune Checkpoints OX40 and OX40L in Small-Cell Lung Cancer: Predict Prognosis and Modulate Immune Microenvironment.
Peixin Chen, Hao Wang, +10 authors, Yayi He.
Front Oncol, 2021 Dec 14; 11. PMID: 34900670    Free PMC article.
Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer.
Saisha A Nalawade, Paul Shafer, +10 authors, Valentina Hoyos.
J Immunother Cancer, 2021 Nov 25; 9(11). PMID: 34815355    Free PMC article.
Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency.
Anirban Das, Sumedha Sudhaman, +80 authors, Uri Tabori.
Nat Med, 2022 Jan 08; 28(1). PMID: 34992263    Free PMC article.
Comprehensive analysis of a TNF family based-signature in diffuse gliomas with regard to prognosis and immune significance.
Qiang-Wei Wang, Wei-Wei Lin, Yong-Jian Zhu.
Cell Commun Signal, 2022 Jan 11; 20(1). PMID: 35000592    Free PMC article.
Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral Lactobacillus plantarum.
Jianqing Xu, Zhihong Ren, +11 authors, Jianguo Xu.
Front Nutr, 2022 Jan 11; 8. PMID: 35004816    Free PMC article.
Transcriptomic profiling reveals gene expression in human peripheral blood after exposure to low-dose ionizing radiation.
Fang Fang, Xiaoling Yu, +5 authors, Jue Li.
J Radiat Res, 2021 Nov 18; 63(1). PMID: 34788452    Free PMC article.
Co-Stimulatory Molecules during Immune Control of Epstein Barr Virus Infection.
Christian Münz.
Biomolecules, 2022 Jan 22; 12(1). PMID: 35053187    Free PMC article.
Spatial Profiling Identifies Prognostic Features of Response to Adjuvant Therapy in Triple Negative Breast Cancer (TNBC).
Arutha Kulasinghe, James Monkman, +3 authors, Ken O'Byrne.
Front Oncol, 2022 Jan 28; 11. PMID: 35083152    Free PMC article.
Role of the adaptive immune system in diabetic kidney disease.
Lingyun Kong, Sofianos Andrikopoulos, +6 authors, Elif I Ekinci.
J Diabetes Investig, 2021 Dec 01; 13(2). PMID: 34845863    Free PMC article.
Hypoxia-Inducible Factor-2 Alpha Regulates the Migration of Fibroblast-like Synoviocytes via Oxidative Stress-Induced CD70 Expression in Patients with Rheumatoid Arthritis.
Su-Jin Yoo, Ha-Reum Lee, +3 authors, Seong Wook Kang.
Int J Mol Sci, 2022 Feb 27; 23(4). PMID: 35216458    Free PMC article.
Bystander T cells in cancer immunology and therapy.
Stefanie L Meier, Ansuman T Satpathy, Daniel K Wells.
Nat Cancer, 2022 Mar 02; 3(2). PMID: 35228747
Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling.
Federica Agliano, Timofey A Karginov, +2 authors, Anthony T Vella.
iScience, 2022 Mar 05; 25(3). PMID: 35243268    Free PMC article.
Enabling the next steps in cancer immunotherapy: from antibody-based bispecifics to multispecifics, with an evolving role for bioconjugation chemistry.
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RSC Chem Biol, 2022 Apr 02; 3(2). PMID: 35360884    Free PMC article.
Twist1 in T Lymphocytes Augments Kidney Fibrosis after Ureteral Obstruction.
Jiafa Ren, Xiaohan Lu, +2 authors, Steven D Crowley.
Kidney360, 2022 Apr 05; 2(5). PMID: 35373065    Free PMC article.
Comprehensive Molecular Analyses of a TNF Family-Based Gene Signature as a Potentially Novel Prognostic Biomarker for Cervical Cancer.
Yan Ma, Xiaoyan Zhang, +3 authors, Jianping Qiu.
Front Oncol, 2022 Apr 09; 12. PMID: 35392242    Free PMC article.
T cell response in patients with COVID-19.
Lian Liu, Ling Xu, Chen Lin.
Blood Sci, 2020 Jul 25; 2(3). PMID: 35402822    Free PMC article.
T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.
Karin H Simons, Alwin de Jong, +3 authors, Paul H A Quax.
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