TNF/TNFR family members in costimulation of T cell responses

Tania H Watts ¹

Affiliations

¹ Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. tania.watts@utoronto.ca

PMID: 15771565
529 citations

Abstract

Several members of the tumor necrosis factor receptor (TNFR) family function after initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB (CD137), OX40 (CD134), HVEM, CD30, and GITR, all of which can have costimulatory effects on T cells. The effects of these costimulatory TNFR family members can often be functionally, temporally, or spatially segregated from those of CD28 and from each other. The sequential and transient regulation of T cell activation/survival signals by different costimulators may function to allow longevity of the response while maintaining tight control of T cell survival. Depending on the disease condition, stimulation via costimulatory TNF family members can exacerbate or ameliorate disease. Despite these complexities, stimulation or blockade of TNFR family costimulators shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity.

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Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens. Anik L Côté, Peisheng Zhang, +5 authors, Mary Jo Turk. less J Immunol, 2010 Nov 26; 186(1). PMID: 21106849 Free PMC article.
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Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance? Peter J L Lane, Fabrina M Gaspal, +2 authors, Fiona M McConnell, David R Withers, Graham Anderson. less Front Immunol, 2012 May 09; 3. PMID: 22566908 Free PMC article.
Decreased expression of T-cell costimulatory molecule CD28 on CD4 and CD8 T cells of mexican patients with pulmonary tuberculosis. German Bernal-Fernandez, Patricia Espinosa-Cueto, +2 authors, Raul Mancilla. less Tuberc Res Treat, 2010 Jan 01; 2010. PMID: 22567259 Free PMC article.
Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells. Ann J McPherson, Laura M Snell, Tak W Mak, Tania H Watts. J Biol Chem, 2012 May 10; 287(27). PMID: 22570473 Free PMC article.
The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity. Jason P Twohig, Morgan Marsden, +6 authors, Eddie C Y Wang. less FASEB J, 2012 May 18; 26(8). PMID: 22593543 Free PMC article.
Regulation of the PKCθ-NF-κB Axis in T Lymphocytes by the Tumor Necrosis Factor Receptor Family Member OX40. Takanori So, Michael Croft. Front Immunol, 2012 Jun 02; 3. PMID: 22654884 Free PMC article.
Cannabinoid-like anti-inflammatory compounds from flax fiber. Monika Styrczewska, Anna Kulma, +2 authors, Jan Szopa. less Cell Mol Biol Lett, 2012 Jun 19; 17(3). PMID: 22706678 Free PMC article.
Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients. A J Robert McGray, Dannie Bernard, +8 authors, Jonathan L Bramson. less Oncoimmunology, 2012 Jul 04; 1(4). PMID: 22754760 Free PMC article.
Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic β-cells. Vineeth Varanasi, Lia Avanesyan, Desiree M Schumann, Alexander V Chervonsky. Diabetes, 2012 Jul 10; 61(11). PMID: 22773667 Free PMC article.
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions. Sonia Feau, Zacarias Garcia, +3 authors, Stephen P Schoenberger. less Nat Commun, 2012 Jul 12; 3. PMID: 22781761 Free PMC article.
Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. S Peter Bak, Mike Stein Barnkob, +3 authors, Jianzhu Chen. less J Immunol, 2012 Jul 17; 189(4). PMID: 22798683 Free PMC article.
OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Xiang Xiao, Savithri Balasubramanian, +7 authors, Xian Chang Li. less Nat Immunol, 2012 Jul 31; 13(10). PMID: 22842344 Free PMC article. Highly Cited.
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ. Shravan Madireddi, Rich-Henry Schabowsky, +3 authors, Haval Shirwan. less PLoS One, 2012 Aug 08; 7(8). PMID: 22870329 Free PMC article.
Nicotine up-regulated 4-1BBL expression by activating Mek-PI3K pathway augments the efficacy of bone marrow-derived dendritic cell vaccination. Hao Jie Jin, Hua Xiu Sui, Yi Nan Wang, Feng Guang Gao. J Clin Immunol, 2012 Aug 18; 33(1). PMID: 22898831
Mtb-specific CD27low CD4 T cells as markers of lung tissue destruction during pulmonary tuberculosis in humans. Irina Yu Nikitina, Natalya A Kondratuk, +4 authors, Irina V Lyadova. less PLoS One, 2012 Sep 01; 7(8). PMID: 22937086 Free PMC article.
CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells. Felix S Lichtenegger, Katharina Mueller, +4 authors, Marion Subklewe. less PLoS One, 2012 Sep 11; 7(9). PMID: 22962607 Free PMC article.
Coinhibitory molecules in autoimmune diseases. Norihiko Watanabe, Hiroshi Nakajima. Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525 Free PMC article. Review.
Advances in the development of cancer immunotherapies. Jianjun Gao, Chantale Bernatchez, +2 authors, Padmanee Sharma, Laszlo G Radvanyi, Patrick Hwu. less Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830 Free PMC article. Review.
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model. Kritika Kachapati, David E Adams, +5 authors, William M Ridgway. less J Immunol, 2012 Oct 16; 189(10). PMID: 23066155 Free PMC article.
Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma. Jie Tian, Jie Ma, +8 authors, Shengjun Wang. less PLoS One, 2012 Oct 19; 7(10). PMID: 23077535 Free PMC article.
T cell vaccinology: exploring the known unknowns. Matt A Burchill, Beth A Tamburini, +3 authors, Ross M Kedl. less Vaccine, 2012 Nov 10; 31(2). PMID: 23137843 Free PMC article. Review.
Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens. Yuan Zhao, Vikas Tahiliani, Shahram Salek-Ardakani, Michael Croft. Front Immunol, 2012 Nov 20; 3. PMID: 23162550 Free PMC article.
Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo. Dass S Vinay, Seung J Lee, +2 authors, Chang H Kim, Ho Sik Oh, Byoung S Kwon. less PLoS One, 2012 Nov 28; 7(11). PMID: 23185591 Free PMC article.
SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner. Sonia Feau, Stephen P Schoenberger, Amnon Altman, Stéphane Bécart. J Immunol, 2012 Dec 01; 190(1). PMID: 23197258 Free PMC article.
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Christopher C Kloss, Maud Condomines, +2 authors, Marc Cartellieri, Michael Bachmann, Michel Sadelain. less Nat Biotechnol, 2012 Dec 18; 31(1). PMID: 23242161 Free PMC article. Highly Cited.
Balance between NF-κB p100 and p52 regulates T cell costimulation dependence. Maria Letizia Giardino Torchia, Dietrich B Conze, Dragana Jankovic, Jonathan D Ashwell. J Immunol, 2012 Dec 19; 190(2). PMID: 23248260 Free PMC article.
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. Ivana Munitic, Mirela Kuka, +2 authors, Atef Allam, Jonathan P Scoville, Jonathan D Ashwell. less J Immunol, 2012 Dec 28; 190(3). PMID: 23269247 Free PMC article.
CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion. Marie-Clare St Rose, Roslyn A Taylor, +4 authors, Adam J Adler. less Immunol Cell Biol, 2013 Jan 09; 91(2). PMID: 23295363 Free PMC article.
The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses. Isabel Barao. Front Immunol, 2013 Jan 15; 3. PMID: 23316193 Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation. Sheng Yao, Yuwen Zhu, Lieping Chen. Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250 Free PMC article. Highly Cited. Review.
CD4(+) T-cell subsets in intestinal inflammation. Matthew Shale, Chris Schiering, Fiona Powrie. Immunol Rev, 2013 Feb 15; 252(1). PMID: 23405904 Free PMC article. Review.
Recombinant Salmonella-based 4-1BBL vaccine enhances T cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL. Jianxin Ye, Ling Li, +3 authors, Weichang Chen. less J Biomed Sci, 2013 Feb 19; 20. PMID: 23413971 Free PMC article.
The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. Amy E Moran, Magdalena Kovacsovics-Bankowski, Andrew D Weinberg. Curr Opin Immunol, 2013 Feb 19; 25(2). PMID: 23414607 Free PMC article. Review.
Bayesian approach to model CD137 signaling in human M. tuberculosis in vitro responses. Darío A Fernández Do Porto, Jerónimo Auzmendi, +2 authors, Delfina Peña, Verónica E García, Luciano Moffatt. less PLoS One, 2013 Feb 26; 8(2). PMID: 23437083 Free PMC article.
CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs. Pablo A Romagnoli, Mary F Premenko-Lanier, Gilbert D Loria, John D Altman. PLoS One, 2013 Feb 27; 8(2). PMID: 23441229 Free PMC article.
Agonist antibodies to TNFR molecules that costimulate T and NK cells. Ignacio Melero, Daniel Hirschhorn-Cymerman, +2 authors, Jedd D Wolchok. less Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460535 Free PMC article. Highly Cited.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation. Adam J Adler, Anthony T Vella. Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891 Free PMC article.
In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-versus-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor. Kateryna Soloviova, Maksym Puliaiev, Mark Haas, Charles S Via. J Immunol, 2013 Mar 26; 190(9). PMID: 23526821 Free PMC article.
CD137 expressed on neutrophils plays dual roles in antibacterial responses against Gram-positive and Gram-negative bacterial infections. Quang-Tam Nguyen, Thu-Ha T Nguyen, +8 authors, Byung-Sam Kim. less Infect Immun, 2013 Apr 03; 81(6). PMID: 23545301 Free PMC article.
Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy. Yan Zheng, Yuanyuan Zha, +4 authors, Thomas F Gajewski. less Mol Immunol, 2013 Apr 04; 55(3-4). PMID: 23548837 Free PMC article.
Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy. Jessica Ann Chacon, Richard C Wu, +6 authors, Laszlo Radvanyi. less PLoS One, 2013 Apr 06; 8(4). PMID: 23560068 Free PMC article.
Immunosenescence and organ transplantation. Timm Heinbokel, Abdallah Elkhal, +2 authors, Guangxiang Liu, Karoline Edtinger, Stefan G Tullius. less Transplant Rev (Orlando), 2013 May 04; 27(3). PMID: 23639337 Free PMC article. Review.
CD137 is induced by the CD40 signal on chronic lymphocytic leukemia B cells and transduces the survival signal via NF-κB activation. Yukana Nakaima, Ken Watanabe, +2 authors, Takatoshi Koyama, Osamu Miura, Tetsuya Fukuda. less PLoS One, 2013 May 23; 8(5). PMID: 23696891 Free PMC article.
Novel antibodies targeting immune regulatory checkpoints for cancer therapy. Chern Siang Lee, Mark Cragg, Martin Glennie, Peter Johnson. Br J Clin Pharmacol, 2013 May 25; 76(2). PMID: 23701301 Free PMC article. Review.
Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules. Takanori So, Michael Croft. Front Immunol, 2013 Jun 14; 4. PMID: 23760533 Free PMC article.
P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway. Hanan Galski, Tamar Oved-Gelber, +3 authors, Arnon Nagler. less Biochem Pharmacol, 2013 Jun 19; 86(5). PMID: 23774624 Free PMC article.
B7-H5 costimulates human T cells via CD28H. Yuwen Zhu, Sheng Yao, +13 authors, Lieping Chen. less Nat Commun, 2013 Jun 21; 4. PMID: 23784006 Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer. Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer. less Front Immunol, 2013 Jun 27; 4. PMID: 23801991 Free PMC article.
Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis. Gang Cen, Weidong Wu. Tumour Biol, 2013 Jul 04; 34(6). PMID: 23821300
Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy. Edwin Bremer. ISRN Oncol, 2013 Jul 11; 2013. PMID: 23840967 Free PMC article.
Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice. Michael E Wortzman, Gloria H Y Lin, Tania H Watts. PLoS One, 2013 Jul 23; 8(7). PMID: 23874808 Free PMC article.
4-1BB signaling activates the t cell factor 1 effector/β-catenin pathway with delayed kinetics via ERK signaling and delayed PI3K/AKT activation to promote the proliferation of CD8+ T Cells. Do Y Lee, Beom K Choi, +4 authors, Byoung S Kwon. less PLoS One, 2013 Jul 23; 8(7). PMID: 23874982 Free PMC article.
Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis. Jian-yong Yu, Li Li, +4 authors, Xi-lin Song. less Tumour Biol, 2013 Aug 01; 34(6). PMID: 23900678
CD70 is downregulated by interaction with CD27. Mirela Kuka, Ivana Munitic, Maria Letizia Giardino Torchia, Jonathan D Ashwell. J Immunol, 2013 Aug 06; 191(5). PMID: 23913967 Free PMC article.
A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory. Alexander M Rowe, Susan E Murray, +3 authors, David C Parker. less J Immunol, 2013 Sep 06; 191(7). PMID: 24006459 Free PMC article.
CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor. Qunrui Ye, De-Gang Song, +5 authors, Daniel J Powell. less Clin Cancer Res, 2013 Sep 21; 20(1). PMID: 24045181 Free PMC article. Highly Cited.
Effects of OX40-OX40L interaction on the nuclear factor of activated T cells c1 in ApoE-deficient mice. Jin-chuan Yan, Liang-jie Xu, Cui-ping Wang, Zhong-qun Wang. Inflammation, 2013 Sep 21; 37(1). PMID: 24045961
The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Jianhui Ma, Bo-Ram Bang, +10 authors, Young Jun Kang. less Sci Signal, 2013 Oct 03; 6(295). PMID: 24084649 Free PMC article.
Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics. Sachin Gupta, James M Termini, Saravana Kanagavelu, Geoffrey W Stone. Immunol Res, 2013 Nov 08; 57(1-3). PMID: 24198065 Free PMC article. Review.
CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA. Rachel Flynn, Tarun Hutchinson, +3 authors, Shahram Salek-Ardakani. less PLoS One, 2013 Nov 10; 8(10). PMID: 24205056 Free PMC article.
Iterative feature removal yields highly discriminative pathways. Stephen O'Hara, Kun Wang, +5 authors, Michael Kirby. less BMC Genomics, 2013 Nov 28; 14. PMID: 24274115 Free PMC article.
Targeting CD137 enhances vaccine-elicited anti-respiratory syncytial virus CD8+ T cell responses in aged mice. Sujin Lee, Robert S Mittler, Martin L Moore. J Immunol, 2013 Nov 29; 192(1). PMID: 24285837 Free PMC article.
Continuous 4-1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy. Jessica Ann Chacon, Shari Pilon-Thomas, Amod A Sarnaik, Laszlo G Radvanyi. Oncoimmunology, 2013 Dec 10; 2(9). PMID: 24319633 Free PMC article.
Cognate antigen stimulation generates potent CD8(+) inflammatory effector T cells. Hsueh-Cheng Sung, Sara Lemos, +6 authors, César Evaristo. less Front Immunol, 2014 Jan 01; 4. PMID: 24379814 Free PMC article.
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy? Amit Kumar, Wasim Abbas, Georges Herbein. Mediators Inflamm, 2014 Jan 24; 2013. PMID: 24453421 Free PMC article. Review.
Human and mouse CD137 have predominantly different binding CRDs to their respective ligands. Ling Yi, Yanlin Zhao, +4 authors, Hongtao Zhang. less PLoS One, 2014 Jan 28; 9(1). PMID: 24466035 Free PMC article.
TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases. Luis M Blanco-Colio. Front Immunol, 2014 Jan 31; 5. PMID: 24478772 Free PMC article. Review.
4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy. Dass S Vinay, Byoung S Kwon. BMB Rep, 2014 Feb 07; 47(3). PMID: 24499671 Free PMC article. Review.
Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients. Qunrui Ye, De-Gang Song, Daniel J Powell. Oncoimmunology, 2014 Feb 07; 2(12). PMID: 24501691 Free PMC article.
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs. Lei Lu, Xiaobing Xu, +3 authors, Xuan Wang. less J Transl Med, 2014 Feb 08; 12. PMID: 24502656 Free PMC article.
Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice. Judith T Murphy, Andre P Burey, +4 authors, Jedd D Wolchok. less Blood, 2014 Feb 22; 123(14). PMID: 24558202 Free PMC article.
The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice. Petra Krause, Sonja P Zahner, +3 authors, Mitchell Kronenberg. less Gastroenterology, 2014 Feb 25; 146(7). PMID: 24560868 Free PMC article.
The TNF family in T cell differentiation and function--unanswered questions and future directions. Michael Croft. Semin Immunol, 2014 Mar 13; 26(3). PMID: 24613728 Free PMC article. Review.
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer. Yukiko Tone, Yoko Kidani, +5 authors, Masahide Tone. less J Immunol, 2014 Mar 19; 192(8). PMID: 24634496 Free PMC article.
Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens. Pablo Penaloza-MacMaster, Jeffrey E Teigler, +7 authors, Dan H Barouch. less J Virol, 2014 Mar 22; 88(11). PMID: 24648461 Free PMC article.
Association between tumor necrosis factor-alpha gene polymorphisms and prostate cancer risk: a meta-analysis. Liping Ma, Jiangyang Zhao, +5 authors, Shan Li. less Diagn Pathol, 2014 Mar 29; 9. PMID: 24666463 Free PMC article. Review.
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Hiroyuki Nagashima, Yuko Okuyama, +6 authors, Takanori So. less Nat Immunol, 2014 Apr 01; 15(5). PMID: 24681564 Free PMC article.
Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity. William L Redmond, Stefanie N Linch, Melissa J Kasiewicz. Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778278 Free PMC article.
Sarcoma immunotherapy: past approaches and future directions. S P D'Angelo, W D Tap, G K Schwartz, R D Carvajal. Sarcoma, 2014 Apr 30; 2014. PMID: 24778572 Free PMC article. Review.
Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells. Anita Kumari, Ercan Cacan, Susanna F Greer, Charlie Garnett-Benson. J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829753 Free PMC article.
Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata. Marta Bertolini, Federica Zilio, +9 authors, Ralf Paus. less PLoS One, 2014 May 17; 9(5). PMID: 24832234 Free PMC article.
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy. David A Schaer, Daniel Hirschhorn-Cymerman, Jedd D Wolchok. J Immunother Cancer, 2014 May 24; 2. PMID: 24855562 Free PMC article. Review.
Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses. Atef Allam, Melissa Swiecki, +2 authors, William Vermi, Jonathan D Ashwell, Marco Colonna. less J Immunol, 2014 Jun 11; 193(2). PMID: 24913981 Free PMC article.
p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression. Yong Lu, Mingjun Zhang, +9 authors, Qing Yi. less Nat Commun, 2014 Jun 25; 5. PMID: 24957461 Free PMC article.
Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. Shravan Madireddi, So-Young Eun, +7 authors, Michael Croft. less J Exp Med, 2014 Jun 25; 211(7). PMID: 24958847 Free PMC article.
Herpesvirus entry mediator (HVEM) attenuates signals mediated by the lymphotoxin β receptor (LTβR) in human cells stimulated by the shared ligand LIGHT. John Bechill, William J Muller. Mol Immunol, 2014 Jul 02; 62(1). PMID: 24980868 Free PMC article.
Detailed study of the interaction between human herpesvirus 6B glycoprotein complex and its cellular receptor, human CD134. Huamin Tang, Junjie Wang, Nora F Mahmoud, Yasuko Mori. J Virol, 2014 Jul 11; 88(18). PMID: 25008928 Free PMC article.
Human genetic evidence for involvement of CD137 in atherosclerosis. Leif Å Söderström, Karl Gertow, +13 authors, Peder S Olofsson. less Mol Med, 2014 Jul 18; 20. PMID: 25032953 Free PMC article.
Tumour necrosis factor superfamily members in the pathogenesis of inflammatory bowel disease. Tomasz J Ślebioda, Zbigniew Kmieć. Mediators Inflamm, 2014 Jul 22; 2014. PMID: 25045210 Free PMC article. Review.
JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses. Anthony Joetham, Michaela Schedel, +6 authors, Erwin W Gelfand. less J Immunol, 2014 Jul 30; 193(5). PMID: 25070841 Free PMC article.
CD137 signaling enhances tight junction resistance in intestinal epithelial cells. Veronica Gusti, Kaila M Bennett, David D Lo. Physiol Rep, 2014 Aug 07; 2(8). PMID: 25096552 Free PMC article.
Costimulatory molecules as vaccine adjuvants: to 4-1BB or not to 4-1BB? Khalidur Rahman, Smita S Iyer. Cell Mol Immunol, 2014 Sep 10; 12(4). PMID: 25195512 Free PMC article. Review.
Therapeutic targeting of the inflammome. Kyle T Wright, Charles Giardina, Anthony T Vella. Biochem Pharmacol, 2014 Sep 11; 92(2). PMID: 25204592 Free PMC article. Review.
SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines. Abhishek K Srivastava, Gunes Dinc, +3 authors, Haval Shirwan. less Cancer Res, 2014 Sep 26; 74(22). PMID: 25252915 Free PMC article.
CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression. Selena Viganò, Riddhima Banga, +5 authors, Matthieu Perreau. less PLoS Pathog, 2014 Sep 26; 10(9). PMID: 25255144 Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy. Stephanie R Jackson, Jinyun Yuan, Ryan M Teague. Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416 Free PMC article. Review.
Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system. Dhifaf Sarhan, Padraig D'Arcy, Andreas Lundqvist. Int J Mol Sci, 2014 Oct 16; 15(10). PMID: 25318057 Free PMC article. Review.
Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. Evgeniy B Eruslanov, Pratik S Bhojnagarwala, +11 authors, Sunil Singhal. less J Clin Invest, 2014 Nov 11; 124(12). PMID: 25384214 Free PMC article. Highly Cited.
Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy. Jessica Ann Chacon, Amod A Sarnaik, +7 authors, Laszlo Radvanyi. less Clin Cancer Res, 2014 Dec 05; 21(3). PMID: 25472998 Free PMC article.
Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects. C Preston Neff, Jennifer L Chain, +6 authors, Andrew P Fontenot. less Am J Respir Crit Care Med, 2014 Dec 24; 191(4). PMID: 25536276 Free PMC article.
Immune checkpoint receptors in regulating immune reactivity in rheumatic disease. Sabrina Ceeraz, Elizabeth C Nowak, Christopher M Burns, Randolph J Noelle. Arthritis Res Ther, 2015 Jan 22; 16(5). PMID: 25606596 Free PMC article. Review.
TNF superfamily protein-protein interactions: feasibility of small- molecule modulation. Yun Song, Peter Buchwald. Curr Drug Targets, 2015 Feb 24; 16(4). PMID: 25706111 Free PMC article. Review.
Monocyte-derived dendritic cells from cirrhotic patients retain similar capacity for maturation/activation and antigen presentation as those from healthy subjects. Shiroh Tanoue, Li-Yuan Chang, Yonghai Li, David E Kaplan. Cell Immunol, 2015 Mar 04; 295(1). PMID: 25734547 Free PMC article.
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection. Maria Fernanda Pascutti, Sulima Geerman, +6 authors, Martijn A Nolte. less PLoS Pathog, 2015 Mar 05; 11(3). PMID: 25738498 Free PMC article.
Reducing toxicity of 4-1BB costimulation: targeting 4-1BB ligands to the tumor stroma with bi-specific aptamer conjugates. B Schrand, A Berezhnoy, +3 authors, R Brenneman, A Williams, A Levay, E Gilboa. less Oncoimmunology, 2015 May 08; 4(3). PMID: 25949891 Free PMC article.
Combinatorial Immunoprofiling in Latent Tuberculosis Infection. Toward Better Risk Stratification. Patricio Escalante, Tobias Peikert, +10 authors, Andrew H Limper. less Am J Respir Crit Care Med, 2015 Jun 02; 192(5). PMID: 26030344 Free PMC article.
Signaling in lymphocyte activation. Doreen Cantrell. Cold Spring Harb Perspect Biol, 2015 Jun 03; 7(6). PMID: 26032717 Free PMC article. Review.
Targeting signaling factors for degradation, an emerging mechanism for TRAF functions. Xiao-Dong Yang, Shao-Cong Sun. Immunol Rev, 2015 Jun 19; 266(1). PMID: 26085207 Free PMC article. Review.
c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. Maria Letizia Giardino Torchia, Ivana Munitic, +3 authors, Jonathan D Ashwell. less Eur J Immunol, 2015 Jun 23; 45(9). PMID: 26096449 Free PMC article.
The pharmacology of second-generation chimeric antigen receptors. Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain. Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802 Free PMC article. Highly Cited. Review.
Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing. Ti-Hsuan Ku, Tiantian Zhang, +4 authors, Yu-Hwa Lo. less Sensors (Basel), 2015 Jul 15; 15(7). PMID: 26153774 Free PMC article. Review.
Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme. Liu Yang, Geng Guo, Xiao-yuan Niu, Jing Liu. Biomed Res Int, 2015 Jul 15; 2015. PMID: 26167495 Free PMC article. Review.
Heterogeneous susceptibility for uraemic media calcification and concomitant inflammation within the arterial tree. Alexander H Kirsch, Andrijana Kirsch, +13 authors, Philipp Eller. less Nephrol Dial Transplant, 2015 Jul 18; 30(12). PMID: 26185049 Free PMC article.
Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2. Wenhai Liu, Antoine Menoret, Anthony T Vella. Cell Mol Immunol, 2015 Jul 21; 14(3). PMID: 26189366 Free PMC article.
Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon. Mengjie Lv, Weiwei Wu, Yuejiao Zhang, Mingzhao Zhu. Sci Rep, 2015 Aug 08; 5. PMID: 26245828 Free PMC article.
Role of Tumor Necrosis Factor Superfamily in Neuroinflammation and Autoimmunity. Sandip Sonar, Girdhari Lal. Front Immunol, 2015 Aug 11; 6. PMID: 26257732 Free PMC article. Review.
Enhancing Human Immunodeficiency Virus-Specific CD8(+) T Cell Responses with Heteroclitic Peptides. Adeolu Oyemade Adegoke, Michael David Grant. Front Immunol, 2015 Aug 11; 6. PMID: 26257743 Free PMC article. Review.
TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex. Jian-hong Shi, Shao-Cong Sun. Mol Immunol, 2015 Aug 12; 68(2 Pt C). PMID: 26260210 Free PMC article. Review.
Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response. Julia Merkenschlager, George Kassiotis. Front Immunol, 2015 Sep 01; 6. PMID: 26322045 Free PMC article. Review.
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Xiang Xiao, Xiaomin Shi, +8 authors, Xian Chang Li. less Nat Commun, 2015 Sep 15; 6. PMID: 26365427 Free PMC article.
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Red blood cell alloimmunization is influenced by the delay between Toll-like receptor agonist injection and transfusion. Rahma Elayeb, Marie Tamagne, +2 authors, Benoît Vingert. less Haematologica, 2015 Oct 03; 101(2). PMID: 26430173 Free PMC article.
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Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response. Manisha Pathak, Pankaj Sharma, +3 authors, Shailja Misra-Bhattacharya. less Immunology, 2015 Oct 27; 147(2). PMID: 26501838 Free PMC article.
B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Responses After Transplantation. J Marino, J T Paster, +4 authors, G Benichou. less Am J Transplant, 2015 Nov 10; 16(2). PMID: 26552037 Free PMC article.
Emerging targets in cancer immunotherapy: beyond CTLA-4 and PD-1. Amer Assal, Justin Kaner, Gopichand Pendurti, Xingxing Zang. Immunotherapy, 2015 Nov 17; 7(11). PMID: 26567614 Free PMC article. Review.
Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells. Dajana Reuter, Martin S Staege, Caspar D Kühnöl, Jürgen Föll. Front Oncol, 2015 Nov 19; 5. PMID: 26579494 Free PMC article.
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Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers. I V Lyadova, A V Panteleev. Mediators Inflamm, 2015 Dec 08; 2015. PMID: 26640327 Free PMC article. Highly Cited. Review.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy. Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake. Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632 Free PMC article. Review.
Generating Peripheral Blood Derived Lymphocytes Reacting Against Autologous Primary AML Blasts. Rohtesh S Mehta, Xiaohua Chen, +2 authors, Jeyaraj Antony, Michael Boyiadzis, Paul Szabolcs. less J Immunother, 2016 Feb 06; 39(2). PMID: 26849076 Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella. Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028 Free PMC article. Review.
Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade. Anita Kumari, Charlie Garnett-Benson. BMC Res Notes, 2016 Feb 14; 9. PMID: 26872462 Free PMC article.
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium. Eileen S Kim, Jennifer E Kim, +3 authors, Michael Lim. less J Immunol Res, 2016 Feb 18; 2016. PMID: 26881264 Free PMC article. Review.
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. Taizou Hirano, Toshiaki Kikuchi, +12 authors, Masakazu Ichinose. less EMBO Mol Med, 2016 Mar 16; 8(4). PMID: 26976612 Free PMC article.
4-1BB agonism: adding the accelerator to cancer immunotherapy. Cariad Chester, Siddhant Ambulkar, Holbrook E Kohrt. Cancer Immunol Immunother, 2016 Apr 02; 65(10). PMID: 27034234 Free PMC article. Review.
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease. John Attanasio, E John Wherry. Immunity, 2016 May 19; 44(5). PMID: 27192569 Free PMC article. Highly Cited. Review.
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The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways. Xiang Xiao, Xiaomin Shi, +7 authors, Xian Chang Li. less Immunity, 2016 Jun 19; 44(6). PMID: 27317259 Free PMC article.
B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity. Federica Piancone, Marina Saresella, +8 authors, Mario Clerici. less Sci Rep, 2016 Jul 15; 6. PMID: 27412504 Free PMC article.
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Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma. Blanca Homet Moreno, Stephen Mok, +2 authors, Antoni Ribas. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622011 Free PMC article.
Molecular pathways driving disease-specific alterations of intestinal epithelial cells. Rocío López-Posadas, Markus F Neurath, Imke Atreya. Cell Mol Life Sci, 2016 Sep 15; 74(5). PMID: 27624395 Review.
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Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma. Shiro Kimbara, Shunsuke Kondo. World J Gastroenterol, 2016 Sep 28; 22(33). PMID: 27672267 Free PMC article. Review.
Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice. Chao Li, Sitong Du, +5 authors, Jie Chen. less Theranostics, 2016 Oct 05; 6(12). PMID: 27698940 Free PMC article.
Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation. Jeffrey J Teoh, Awndre E Gamache, +4 authors, Michael G Brown. less J Immunol, 2016 Nov 01; 197(11). PMID: 27798162 Free PMC article.
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TNF superfamily cytokines in the promotion of Th9 differentiation and immunopathology. Françoise Meylan, Richard M Siegel. Semin Immunopathol, 2016 Nov 30; 39(1). PMID: 27896636 Free PMC article. Review.
Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy. Adam J Adler, Payal Mittal, +3 authors, Anthony T Vella. less Immunotherapy, 2016 Dec 22; 9(1). PMID: 28000531 Free PMC article. Review.
Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection. Kazushi Izawa, Emmanuel Martin, +13 authors, Sylvain Latour. less J Exp Med, 2016 Dec 25; 214(1). PMID: 28011863 Free PMC article.
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Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy. Roberta Aliperta, Petra B Welzel, +14 authors, Michael P Bachmann. less Sci Rep, 2017 Feb 17; 7. PMID: 28205621 Free PMC article.
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases. Michael Croft, Richard M Siegel. Nat Rev Rheumatol, 2017 Mar 10; 13(4). PMID: 28275260 Free PMC article. Highly Cited. Review.
Amelioration of Inflammatory Cytokines Mix Stimulation: A Pretreatment of CD137 Signaling Study on VSMC. Wei Zhong, Bo Li, +5 authors, Jin Chuan Yan. less Mediators Inflamm, 2017 Mar 11; 2017. PMID: 28280290 Free PMC article.
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OX40 signaling is involved in the autoactivation of CD4+CD28- T cells and contributes to the pathogenesis of autoimmune arthritis. Juean Jiang, Cuiping Liu, +7 authors, Xueguang Zhang. less Arthritis Res Ther, 2017 Mar 23; 19(1). PMID: 28320444 Free PMC article.
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Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function. Nicholas D Leigh, Rachel E O'Neill, +6 authors, Xuefang Cao. less J Immunol, 2017 May 28; 199(1). PMID: 28550198 Free PMC article.
Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives. Clizia Zichi, Marcello Tucci, +5 authors, Massimo Di Maio. less Biomed Res Int, 2017 Jul 07; 2017. PMID: 28680882 Free PMC article. Review.
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Enhanced immune-modulatory effects of thalidomide and dexamethasone co-treatment on T cell subsets. Eun Jee Kim, Jae Geun Lee, +6 authors, Yu Seun Kim. less Immunology, 2017 Aug 02; 152(4). PMID: 28758197 Free PMC article.
Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy. Rajeev Shrimali, Shamim Ahmad, +7 authors, Samir N Khleif. less J Immunother Cancer, 2017 Aug 16; 5(1). PMID: 28807056 Free PMC article.
HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity. Pritesh Desai, Georges Abboud, +5 authors, Shahram Salek-Ardakani. less J Immunol, 2017 Sep 03; 199(8). PMID: 28864473 Free PMC article.
CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice. Angela C Zhou, Laura M Snell, Michael E Wortzman, Tania H Watts. Front Immunol, 2017 Oct 11; 8. PMID: 28993768 Free PMC article.
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