. 2005 Mar; 23:515-48.
doi: 10.1146/annurev.immunol.23.021704.115611.

The B7 family revisited

Rebecca J Greenwald 1 Gordon J Freeman  Arlene H Sharpe  
  • PMID: 15771580
  •     846 citations


The discovery of new functions for the original B7 family members, together with the identification of additional B7 and CD28 family members, have revealed new ways in which the B7:CD28 family regulates T cell activation and tolerance. B7-1/B7-2:CD28 interactions not only promote initial T cell activation but also regulate self-tolerance by supporting CD4+CD25+ T regulatory cell homeostasis. CTLA-4 can exert its inhibitory effects in both B7-1/B7-2 dependent and independent fashions. B7-1 and B7-2 can signal bidirectionally by engaging CD28 and CTLA-4 on T cells and by delivering signals into B7-expressing cells. The five new B7 family members, ICOS ligand, PD-L1 (B7-H1), PD-L2 (B7-DC), B7-H3, and B7-H4 (B7x/B7-S1) are expressed on professional antigen-presenting cells as well as on cells within nonlymphoid organs, providing new means for regulating T cell activation and tolerance in peripheral tissues. The new CD28 families members, ICOS, PD-1, and BTLA, are inducibly expressed on T cells, and they have important roles in regulating previously activated T cells. PD-1 and BTLA also are expressed on B cells and may have broader immunoregulatory functions. The ICOS:ICOSL pathway appears to be particularly important for stimulating effector T cell responses and T cell-dependent B cell responses, but it also has an important role in regulating T cell tolerance. In addition, the PD-1:PD-L1/PD-L2 pathway plays a critical role in regulating T cell activation and tolerance. In this review, we revisit the roles of the B7:CD28 family members in regulating immune responses, and we discuss their therapeutic potential.

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NK T cells provide lipid antigen-specific cognate help for B cells.
Elizabeth A Leadbetter, Manfred Brigl, +5 authors, Michael B Brenner.
Proc Natl Acad Sci U S A, 2008 Jun 14; 105(24). PMID: 18550809    Free PMC article.
Highly Cited.
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
Baowei Peng, Peiqing Ye, +4 authors, Carol H Miao.
Blood, 2008 Jun 25; 112(5). PMID: 18574023    Free PMC article.
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.
Fabienne Haspot, Thomas Fehr, +5 authors, Megan Sykes.
Blood, 2008 Jun 26; 112(5). PMID: 18577709    Free PMC article.
Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways.
Carl F Ware.
Immunol Rev, 2008 Jul 11; 223. PMID: 18613837    Free PMC article.
Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.
Carrie Gibbons, Megan Sykes.
Immunol Rev, 2008 Jul 11; 223. PMID: 18613846    Free PMC article.
Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.
Michael Schindler, Jan Schmökel, +7 authors, Frank Kirchhoff.
PLoS Pathog, 2008 Jul 19; 4(7). PMID: 18636106    Free PMC article.
Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Eszter Lázár-Molnár, Qingrong Yan, +3 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2008 Jul 22; 105(30). PMID: 18641123    Free PMC article.
PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes.
Adriano Boasso, Andrew W Hardy, +5 authors, Gene M Shearer.
Clin Immunol, 2008 Jul 25; 129(1). PMID: 18650129    Free PMC article.
Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.
Masaaki Hashiguchi, Hiroko Kobori, +3 authors, Miyuki Azuma.
Proc Natl Acad Sci U S A, 2008 Jul 25; 105(30). PMID: 18650384    Free PMC article.
Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance.
Sheng Xia, Zhenhong Guo, +3 authors, Xuetao Cao.
Blood, 2008 Aug 02; 112(8). PMID: 18669892    Free PMC article.
RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes.
Tatjana C Gust, Luisa Neubrandt, +3 authors, Arne von Bonin.
Cell Commun Signal, 2008 Aug 08; 6. PMID: 18684324    Free PMC article.
Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma.
Paul L Crispen, Yuri Sheinin, +9 authors, Eugene D Kwon.
Clin Cancer Res, 2008 Aug 13; 14(16). PMID: 18694993    Free PMC article.
Regulation of T-cell responses by PTEN.
Jodi L Buckler, Xiaohe Liu, Laurence A Turka.
Immunol Rev, 2008 Sep 02; 224. PMID: 18759931    Free PMC article.
PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity.
Irina V Pinchuk, Jamal I Saada, +6 authors, Don W Powell.
Gastroenterology, 2008 Sep 02; 135(4). PMID: 18760278    Free PMC article.
SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation.
Cris Kamperschroer, Deborah M Roberts, +2 authors, Susan L Swain.
J Immunol, 2008 Sep 05; 181(6). PMID: 18768854    Free PMC article.
[Immunmodulatory antibodies in the treatment of skin cancer].
D Schrama, A Hauschild, J C Becker.
Hautarzt, 2008 Sep 09; 59(10). PMID: 18777167
TGF-beta and regulatory T cell in immunity and autoimmunity.
Yisong Y Wan, Richard A Flavell.
J Clin Immunol, 2008 Sep 17; 28(6). PMID: 18792765    Free PMC article.
ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
Xunrong Luo, Kathryn L Pothoven, +8 authors, Stephen D Miller.
Proc Natl Acad Sci U S A, 2008 Sep 18; 105(38). PMID: 18796615    Free PMC article.
Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate to Vgamma2Vdelta 2 TCR.
Huiyong Wei, Dan Huang, +4 authors, Zheng W Chen.
J Immunol, 2008 Sep 20; 181(7). PMID: 18802083    Free PMC article.
Viral infection: a potent barrier to transplantation tolerance.
David M Miller, Thomas B Thornley, Dale L Greiner, Aldo A Rossini.
Clin Dev Immunol, 2008 Sep 26; 2008. PMID: 18815618    Free PMC article.
Immunity, ageing and cancer.
Evelyna Derhovanessian, Rafael Solana, Anis Larbi, Graham Pawelec.
Immun Ageing, 2008 Sep 26; 5. PMID: 18816370    Free PMC article.
Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.
Roland C Zahn, Melisa D Rett, +9 authors, Jörn E Schmitz.
J Virol, 2008 Oct 03; 82(23). PMID: 18829748    Free PMC article.
Subsets of myeloid-derived suppressor cells in tumor-bearing mice.
Je-In Youn, Srinivas Nagaraj, Michelle Collazo, Dmitry I Gabrilovich.
J Immunol, 2008 Oct 04; 181(8). PMID: 18832739    Free PMC article.
Highly Cited.
Dendritic cells: a critical player in cancer therapy?
Anna Karolina Palucka, Hideki Ueno, Joseph Fay, Jacques Banchereau.
J Immunother, 2008 Oct 04; 31(9). PMID: 18833008    Free PMC article.
Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion.
Nicole D Powell, M T Bailey, +4 authors, John F Sheridan.
Brain Behav Immun, 2008 Oct 14; 23(2). PMID: 18848983    Free PMC article.
Emerging concepts in the immunopathogenesis of AIDS.
Daniel C Douek, Mario Roederer, Richard A Koup.
Annu Rev Med, 2008 Oct 25; 60. PMID: 18947296    Free PMC article.
Highly Cited. Review.
Virus-encoded b7-2 costimulation molecules enhance the protective capacity of a replication-defective herpes simplex virus type 2 vaccine in immunocompetent mice.
Sri P Vagvala, Lydia G Thebeau, Saydra R Wilson, Lynda A Morrison.
J Virol, 2008 Nov 07; 83(2). PMID: 18987142    Free PMC article.
T-cell co-stimulatory pathways in autoimmunity.
Jörg J Goronzy, Cornelia M Weyand.
Arthritis Res Ther, 2008 Nov 26; 10 Suppl 1. PMID: 19007423    Free PMC article.
Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.
Jun Abe, Satoshi Ueha, +3 authors, Sho Ishikawa.
Am J Pathol, 2008 Nov 15; 173(6). PMID: 19008373    Free PMC article.
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.
Eun Young Choi, Emmanouil Chavakis, +18 authors, Triantafyllos Chavakis.
Science, 2008 Nov 15; 322(5904). PMID: 19008446    Free PMC article.
Differentiation-induced post-transcriptional control of B7-H1 in human trophoblast cells.
L M Holets, M Z Carletti, +2 authors, M G Petroff.
Placenta, 2008 Nov 18; 30(1). PMID: 19010538    Free PMC article.
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Xin Yu, Kristin Harden, +9 authors, Jane L Grogan.
Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627
Highly Cited.
TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.
Suresh Radhakrishnan, Laura N Arneson, +6 authors, Larry R Pease.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017976    Free PMC article.
T-cell costimulation and coinhibition in atherosclerosis.
Israel Gotsman, Arlene H Sharpe, Andrew H Lichtman.
Circ Res, 2008 Nov 26; 103(11). PMID: 19028921    Free PMC article.
A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.
Quanyi Chen, Jennifer L Cannons, +3 authors, Clifford M Snapper.
J Immunol, 2008 Dec 04; 181(12). PMID: 19050242    Free PMC article.
Urinary CD80 excretion increases in idiopathic minimal-change disease.
Eduardo H Garin, Leila N Diaz, +4 authors, Richard J Johnson.
J Am Soc Nephrol, 2008 Dec 06; 20(2). PMID: 19056875    Free PMC article.
CEACAM1 and the regulation of mucosal inflammation.
T Nagaishi, Z Chen, +3 authors, R S Blumberg.
Mucosal Immunol, 2008 Dec 23; 1 Suppl 1. PMID: 19079227    Free PMC article.
Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population.
Yukiko Narumi, Hajime Isomoto, +7 authors, Kazuhiro Tsukamoto.
J Clin Immunol, 2009 Jan 23; 29(3). PMID: 19160029
CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Josef Kurtz, Forum Raval, +2 authors, Megan Sykes.
Blood, 2009 Jan 31; 113(15). PMID: 19179471    Free PMC article.
The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda.
Isaac Ssewanyana, Chris A R Baker, +7 authors, Huyen Cao.
AIDS Res Hum Retroviruses, 2009 Feb 03; 25(1). PMID: 19182922    Free PMC article.
Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade.
Erika D Reynoso, Kutlu G Elpek, +5 authors, Shannon J Turley.
J Immunol, 2009 Feb 10; 182(4). PMID: 19201863    Free PMC article.
B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.
Oezcan Talay, Ching-Hung Shen, Lieping Chen, Jianzhu Chen.
Proc Natl Acad Sci U S A, 2009 Feb 10; 106(8). PMID: 19202065    Free PMC article.
PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.
Vrajesh V Parekh, Saif Lalani, +6 authors, Luc Van Kaer.
J Immunol, 2009 Feb 24; 182(5). PMID: 19234176    Free PMC article.
Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.
Shahram Salek-Ardakani, Ramon Arens, +3 authors, Michael Croft.
J Immunol, 2009 Feb 24; 182(5). PMID: 19234186    Free PMC article.
Subversion of pulmonary dendritic cell function by paramyxovirus infections.
Antonieta Guerrero-Plata, Deepthi Kolli, +2 authors, Roberto P Garofalo.
J Immunol, 2009 Feb 24; 182(5). PMID: 19234204    Free PMC article.
PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome.
Qianli Meng, Xiaoli Liu, +4 authors, Aize Kijlstra.
Mol Vis, 2009 Feb 24; 15. PMID: 19234630    Free PMC article.
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade.
Nobuhiro Nakamoto, Hyosun Cho, +8 authors, Kyong-Mi Chang.
PLoS Pathog, 2009 Feb 28; 5(2). PMID: 19247441    Free PMC article.
Highly Cited.
The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses.
Alison Crawford, E John Wherry.
Curr Opin Immunol, 2009 Mar 07; 21(2). PMID: 19264470    Free PMC article.
Immunotherapy for liver tumors: present status and future prospects.
Pablo Matar, Laura Alaniz, +7 authors, Guillermo Mazzolini.
J Biomed Sci, 2009 Mar 11; 16. PMID: 19272130    Free PMC article.
Expression of immunosuppresive B7-H3 ligand by hormone-treated prostate cancer tumors and metastases.
Grant Chavin, Yuri Sheinin, +8 authors, R Jeffrey Karnes.
Clin Cancer Res, 2009 Mar 12; 15(6). PMID: 19276267    Free PMC article.
CTLA-4 co-receptor impacts on the function of Treg and CD8+ T-cell subsets.
Christopher E Rudd.
Eur J Immunol, 2009 Mar 14; 39(3). PMID: 19283722    Free PMC article.
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels.
Ulrike Lorenz.
Immunol Rev, 2009 Mar 18; 228(1). PMID: 19290938    Free PMC article.
Highly Cited. Review.
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis.
Xin Huang, Fabienne Venet, +8 authors, Alfred Ayala.
Proc Natl Acad Sci U S A, 2009 Apr 01; 106(15). PMID: 19332785    Free PMC article.
Highly Cited.
Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction.
Xikui Liu, Maria Alexiou, +8 authors, Chen Dong.
J Immunol, 2009 Apr 04; 182(8). PMID: 19342624    Free PMC article.
Tumor recognition and self-recognition induce distinct transcriptional profiles in antigen-specific CD4 T cells.
Derese Getnet, Charles H Maris, +11 authors, Charles G Drake.
J Immunol, 2009 Apr 04; 182(8). PMID: 19342643    Free PMC article.
Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells.
Samuel Yao-Ming Ng, Toshimi Yoshida, Jiangwen Zhang, Katia Georgopoulos.
Immunity, 2009 Apr 07; 30(4). PMID: 19345118    Free PMC article.
Highly Cited.
Fms-like tyrosine kinase 3 ligand increases a lung DC subset with regulatory properties in allergic airway inflammation.
Zhifei Shao, Arpita S Bharadwaj, +2 authors, Devendra K Agrawal.
J Allergy Clin Immunol, 2009 Apr 08; 123(4). PMID: 19348927    Free PMC article.
Tumor vaccines for breast cancer.
Karen S Anderson.
Cancer Invest, 2009 Apr 10; 27(4). PMID: 19358018    Free PMC article.
Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice.
Lili Chen, Wen Cheng, +5 authors, Guangming Zhong.
Infect Immun, 2009 Apr 29; 77(7). PMID: 19398542    Free PMC article.
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.
Daniel E Kaufmann, Bruce D Walker.
J Immunol, 2009 May 06; 182(10). PMID: 19414738    Free PMC article.
Highly Cited. Review.
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
Mojgan Ahmadzadeh, Laura A Johnson, +4 authors, Steven A Rosenberg.
Blood, 2009 May 09; 114(8). PMID: 19423728    Free PMC article.
Highly Cited.
CD28 and CTLA-4 coreceptor expression and signal transduction.
Christopher E Rudd, Alison Taylor, Helga Schneider.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426212    Free PMC article.
Highly Cited. Review.
PD-1 signaling in primary T cells.
James L Riley.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426218    Free PMC article.
Highly Cited. Review.
Sequence, structure, function, immunity: structural genomics of costimulation.
Kausik Chattopadhyay, Eszter Lazar-Molnar, +7 authors, Steven C Almo.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426233    Free PMC article.
B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections.
Trupti Joshi, Susana Rodriguez, +2 authors, Simona Stäger.
PLoS Pathog, 2009 May 14; 5(5). PMID: 19436710    Free PMC article.
Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma.
Halvor S McGee, Devendra K Agrawal.
Am J Respir Crit Care Med, 2009 May 19; 180(3). PMID: 19447898    Free PMC article.
Innate and adaptive immunity in atherosclerosis.
René R S Packard, Andrew H Lichtman, Peter Libby.
Semin Immunopathol, 2009 May 19; 31(1). PMID: 19449008    Free PMC article.
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.
Dong-Ming Kuang, Qiyi Zhao, +4 authors, Limin Zheng.
J Exp Med, 2009 May 20; 206(6). PMID: 19451266    Free PMC article.
Highly Cited.
Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression.
Baohua Zhao, Aihua Song, +6 authors, Jianxun Song.
J Immunol, 2009 May 21; 182(11). PMID: 19454669    Free PMC article.
Hypercostimulation through 4-1BB distorts homeostasis of immune cells.
Seung-Woo Lee, Shahram Salek-Ardakani, Robert S Mittler, Michael Croft.
J Immunol, 2009 May 21; 182(11). PMID: 19454670    Free PMC article.
T-cell co-regulatory molecule expression in renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
Stephen A Boorjian, Yuri Sheinin, +3 authors, Eugene D Kwon.
Urology, 2009 Jun 09; 74(6). PMID: 19501877    Free PMC article.
Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1.
Subash Babu, Sajid Q Bhat, +7 authors, Thomas B Nutman.
J Infect Dis, 2009 Jun 10; 200(2). PMID: 19505258    Free PMC article.
Leukocyte-endothelial interactions in inflammation.
Harald F Langer, Triantafyllos Chavakis.
J Cell Mol Med, 2009 Jun 23; 13(7). PMID: 19538472    Free PMC article.
Increased programmed death-1 molecule expression in cytomegalovirus disease and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Ghislaine M Gallez-Hawkins, Lia Thao, +8 authors, John A Zaia.
Biol Blood Marrow Transplant, 2009 Jun 23; 15(7). PMID: 19539220    Free PMC article.
B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.
Judith Leitner, Christoph Klauser, +9 authors, Peter Steinberger.
Eur J Immunol, 2009 Jun 23; 39(7). PMID: 19544488    Free PMC article.
siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1-infected individuals.
Gaëlle Breton, Bader Yassine-Diab, +4 authors, Ralph M Steinman.
J Clin Immunol, 2009 Jun 30; 29(5). PMID: 19562472    Free PMC article.
B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.
Shikha Malhotra, Susan Kovats, Weiguo Zhang, K Mark Coggeshall.
J Biol Chem, 2009 Jul 10; 284(36). PMID: 19586920    Free PMC article.
Reverse signaling using an inducible costimulator to enhance immunogenic function of dendritic cells.
Gusheng Tang, Qin Qin, +5 authors, Qian Shen.
Cell Mol Life Sci, 2009 Jul 16; 66(18). PMID: 19603141
mTOR: taking cues from the immune microenvironment.
Greg M Delgoffe, Jonathan D Powell.
Immunology, 2009 Jul 17; 127(4). PMID: 19604300    Free PMC article.
Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.
Delphine Sauce, Martin Larsen, +6 authors, Alan B Rickinson.
J Virol, 2009 Jul 17; 83(18). PMID: 19605492    Free PMC article.
CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.
Marleen M Welsh, Katie M Applebaum, +3 authors, Heather H Nelson.
Cancer Res, 2009 Jul 23; 69(15). PMID: 19622768    Free PMC article.
The multifaceted profile of activated microglia.
Marina A Lynch.
Mol Neurobiol, 2009 Jul 25; 40(2). PMID: 19629762
Highly Cited. Review.
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.
Margarida Saraiva, Jillian R Christensen, +3 authors, Anne O'Garra.
Immunity, 2009 Aug 04; 31(2). PMID: 19646904    Free PMC article.
Highly Cited.
Adenovirus receptors and their implications in gene delivery.
Anurag Sharma, Xiaoxin Li, Dinesh S Bangari, Suresh K Mittal.
Virus Res, 2009 Aug 04; 143(2). PMID: 19647886    Free PMC article.
Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?
Marna G Bouwhuis, Andreas Gast, +4 authors, Rajiv Kumar.
Cancer Immunol Immunother, 2009 Aug 13; 59(2). PMID: 19672595    Free PMC article.
Lactoferrin modulation of BCG-infected dendritic cell functions.
Shen-An Hwang, Jeffrey K Actor.
Int Immunol, 2009 Aug 21; 21(10). PMID: 19692539    Free PMC article.
The blockade of T-cell co-stimulation as a therapeutic stratagem for immunosuppression: Focus on belatacept.
Renaud Snanoudj, Carlos Frangié, +5 authors, Bernard Charpentier.
Biologics, 2007 Sep 01; 1(3). PMID: 19707331    Free PMC article.
Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease.
Christine M Freeman, Fernando J Martinez, +8 authors, Jeffrey L Curtis.
Am J Respir Crit Care Med, 2009 Sep 05; 180(12). PMID: 19729666    Free PMC article.
Variable increased expression of program death-1 and program death-1 ligands on peripheral mononuclear cells is not impaired in patients with systemic lupus erythematosus.
Ming-Fei Liu, Chia-Tse Weng, Meng-Yu Weng.
J Biomed Biotechnol, 2009 Sep 18; 2009. PMID: 19759858    Free PMC article.
CD46-induced human Treg enhance B-cell responses.
Anja Fuchs, John P Atkinson, Veronique Fremeaux-Bacchi, Claudia Kemper.
Eur J Immunol, 2009 Sep 29; 39(11). PMID: 19784949    Free PMC article.
The role of costimulatory molecules in allergic disease and asthma.
Vincent Lombardi, Abinav K Singh, Omid Akbari.
Int Arch Allergy Immunol, 2009 Sep 30; 151(3). PMID: 19786798    Free PMC article.
Immunotherapy of cancer.
Hossein Borghaei, Mitchell R Smith, Kerry S Campbell.
Eur J Pharmacol, 2009 Oct 20; 625(1-3). PMID: 19837059    Free PMC article.
Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model.
J Yang, L V Riella, +9 authors, A Chandraker.
Am J Transplant, 2009 Oct 23; 9(12). PMID: 19845593    Free PMC article.
The Parent-into-F1 Model of Graft-vs-Host Disease as a Model of In Vivo T Cell Function and Immunomodulation.
R A Puliaev, I A Puliaeva, A E Ryan, C S Via.
Curr Med Chem Immunol Endocr Metab Agents, 2005 Dec 01; 5(6). PMID: 19865585    Free PMC article.
T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii.
Michael H Shaw, Thornik Reimer, +4 authors, Gabriel Nuñez.
Nat Immunol, 2009 Nov 03; 10(12). PMID: 19881508    Free PMC article.
Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells.
Takayoshi Owada, Norihiko Watanabe, +7 authors, Hiroshi Nakajima.
J Leukoc Biol, 2009 Nov 07; 87(3). PMID: 19892849    Free PMC article.
Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells.
Miho Murakami, Hideyo Ugai, +5 authors, David T Curiel.
Prostate, 2009 Nov 11; 70(4). PMID: 19902467    Free PMC article.
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.
Javier O Valenzuela, Cristina Iclozan, +11 authors, Amer A Beg.
J Clin Invest, 2009 Nov 13; 119(12). PMID: 19907075    Free PMC article.
Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.
Mathieu Gigoux, Jijun Shang, +4 authors, Woong-Kyung Suh.
Proc Natl Acad Sci U S A, 2009 Nov 17; 106(48). PMID: 19915142    Free PMC article.
Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test results.
Subash Babu, Sajid Q Bhat, +2 authors, Thomas B Nutman.
J Infect Dis, 2009 Nov 26; 201(1). PMID: 19929695    Free PMC article.
Characterization of CD4+ T-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming.
Catherine M Rush, Owain R Millington, +3 authors, Paul Garside.
Immunology, 2009 Nov 26; 128(4). PMID: 19930039    Free PMC article.
Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts.
Deepa Rai, Nhat-Long L Pham, John T Harty, Vladimir P Badovinac.
J Immunol, 2009 Nov 26; 183(12). PMID: 19933864    Free PMC article.
B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion.
Friederike C Rau, Jacquelyn Dieter, +2 authors, Nicole Baumgarth.
J Immunol, 2009 Nov 26; 183(12). PMID: 19933871    Free PMC article.
TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells.
Mohamed Elrefaei, Candace M Burke, +4 authors, Huyen Cao.
PLoS One, 2009 Dec 18; 4(12). PMID: 20016783    Free PMC article.
Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer.
Martin Loos, Dennis M Hedderich, +5 authors, Helmut Friess.
BMC Cancer, 2009 Dec 29; 9. PMID: 20035626    Free PMC article.
Putting the brakes on BTLA in T cell-mediated cancer immunotherapy.
Chrystal M Paulos, Carl H June.
J Clin Invest, 2009 Dec 30; 120(1). PMID: 20038807    Free PMC article.
Immune responses to malignancies.
Theresa L Whiteside.
J Allergy Clin Immunol, 2010 Jan 12; 125(2 Suppl 2). PMID: 20061007    Free PMC article.
Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.
Sumeena Bhatia, Kristine Sun, +2 authors, Richard J Hodes.
J Immunol, 2010 Jan 13; 184(4). PMID: 20065109    Free PMC article.
Gatekeepers of intestinal inflammation.
Heather A Arnett, Joanne L Viney.
Inflamm Res, 2010 Jan 13; 59(1). PMID: 20066780
Cell cycle arrest induced by engagement of B7-H4 on Epstein-Barr virus-positive B-cell lymphoma cell lines.
Ga Bin Park, Hyunkeun Song, +7 authors, Dae Y Hur.
Immunology, 2010 Jan 14; 128(3). PMID: 20067536    Free PMC article.
Modulation of T-cell activation by malignant melanoma initiating cells.
Tobias Schatton, Ute Schütte, +8 authors, Markus H Frank.
Cancer Res, 2010 Jan 14; 70(2). PMID: 20068175    Free PMC article.
Highly Cited.
Signals that influence T follicular helper cell differentiation and function.
Michelle A Linterman, Carola G Vinuesa.
Semin Immunopathol, 2010 Jan 29; 32(2). PMID: 20107805
Pathogenesis and management of graft-versus-host disease.
Sung W Choi, John E Levine, James L M Ferrara.
Immunol Allergy Clin North Am, 2010 Feb 02; 30(1). PMID: 20113888    Free PMC article.
Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance.
J L Mollov, C L Lucas, +3 authors, M Sykes.
Am J Transplant, 2010 Feb 04; 10(3). PMID: 20121730    Free PMC article.
Advances in immunosuppression for renal transplantation.
Antoine Durrbach, Helene Francois, +2 authors, Bernard Charpentier.
Nat Rev Nephrol, 2010 Feb 04; 6(3). PMID: 20125095
Peripheral blood gene expression of B7 and CD28 family members associated with tumor progression and microscopic lymphovascular invasion in colon cancer patients.
Hyunji Lee, Ji Hyun Kim, +8 authors, Inhak Choi.
J Cancer Res Clin Oncol, 2010 Feb 09; 136(9). PMID: 20140740
Memory CD8+ T cell differentiation.
Joshua J Obar, Leo Lefrançois.
Ann N Y Acad Sci, 2010 Feb 12; 1183. PMID: 20146720    Free PMC article.
The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation.
Teresa Marafioti, Jennifer C Paterson, +13 authors, Philippe Gaulard.
Haematologica, 2010 Mar 09; 95(3). PMID: 20207847    Free PMC article.
Regulation of natural killer T-cell development by deubiquitinase CYLD.
Andrew J Lee, Xiaofei Zhou, +4 authors, Shao-Cong Sun.
EMBO J, 2010 Mar 13; 29(9). PMID: 20224552    Free PMC article.
T-cell signaling and immunopathologies.
Christopher E Rudd.
Semin Immunopathol, 2010 Mar 20; 32(2). PMID: 20238116
A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma.
Marie-Denise Poirier, Houda Haban, Abdeljabar El Andaloussi.
J Oncol, 2009 Jan 01; 2009. PMID: 20339520    Free PMC article.
Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant.
Anna U Bielinska, Michele Gerber, +5 authors, James R Baker.
Crit Rev Immunol, 2010 Apr 08; 30(2). PMID: 20370629    Free PMC article.
B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals.
Noweeda Mirza, Maria Adelaida Duque, +3 authors, Joseph Lustgarten.
J Immunol, 2010 Apr 09; 184(10). PMID: 20375308    Free PMC article.
Regulatory T cells: immune suppression and beyond.
Yisong Y Wan.
Cell Mol Immunol, 2010 Apr 13; 7(3). PMID: 20383175    Free PMC article.
Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer.
Junko Matsuzaki, Sacha Gnjatic, +9 authors, Kunle Odunsi.
Proc Natl Acad Sci U S A, 2010 Apr 14; 107(17). PMID: 20385810    Free PMC article.
Highly Cited.
T cell pathways involving CTLA4 contribute to a model of acute lung injury.
Takeshi Nakajima, Carlos Jose Suarez, +6 authors, Patricia W Finn.
J Immunol, 2010 Apr 14; 184(10). PMID: 20385880    Free PMC article.
HIV-specific TGF-beta-positive CD4+ T cells do not express regulatory surface markers and are regulated by CTLA-4.
Mohamed Elrefaei, Candace M Burke, +4 authors, Huyen Cao.
AIDS Res Hum Retroviruses, 2010 May 04; 26(3). PMID: 20433405    Free PMC article.
PD-1, gender, and autoimmunity.
Ravi K Dinesh, Bevra H Hahn, Ram Pyare Singh.
Autoimmun Rev, 2010 May 04; 9(8). PMID: 20433954    Free PMC article.
Comparative evaluation of cytokines, T-cell apoptosis, and costimulatory molecule expression in tuberculous and nontuberculous pleurisy.
Priya Rajavelu, Supriya Pokkali, +4 authors, Sulochana D Das.
Clin Transl Sci, 2008 Dec 01; 1(3). PMID: 20443851    Free PMC article.
PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity.
Victor Peña-Cruz, Sean M McDonough, +3 authors, Gordon J Freeman.
J Invest Dermatol, 2010 May 07; 130(9). PMID: 20445553    Free PMC article.
Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.
C M Cuda, L Zeumer, +2 authors, L Morel.
Genes Immun, 2010 May 07; 11(7). PMID: 20445563    Free PMC article.
HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells.
Karlhans F Che, Rachel L Sabado, +5 authors, Marie Larsson.
Eur J Immunol, 2010 May 11; 40(8). PMID: 20455275    Free PMC article.
Immunologic mechanisms in RCC and allogeneic renal transplant rejection.
Jens Bedke, Arnulf Stenzl.
Nat Rev Urol, 2010 May 12; 7(6). PMID: 20458329
Targeting inhibitory pathways in cancer immunotherapy.
Marcio O Lasaro, Hildegund C J Ertl.
Curr Opin Immunol, 2010 May 15; 22(3). PMID: 20466529    Free PMC article.
Chimeric antigen receptor-engineered T cells for immunotherapy of cancer.
Marc Cartellieri, Michael Bachmann, +5 authors, Marc Schmitz.
J Biomed Biotechnol, 2010 May 15; 2010. PMID: 20467460    Free PMC article.
The biologic importance of tumor-infiltrating lymphocytes.
F Stephen Hodi, Glenn Dranoff.
J Cutan Pathol, 2010 May 28; 37 Suppl 1. PMID: 20482675    Free PMC article.
Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.
Tarvo Rajasalu, Helen Brosi, +5 authors, Reinhold Schirmbeck.
Diabetes, 2010 May 21; 59(8). PMID: 20484136    Free PMC article.
CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1.
Elizabeth Charles, Sunil Joshi, +5 authors, Ira J Blader.
Infect Immun, 2010 May 26; 78(8). PMID: 20498261    Free PMC article.
Early events governing memory CD8+ T-cell differentiation.
Joshua J Obar, Leo Lefrançois.
Int Immunol, 2010 May 28; 22(8). PMID: 20504887    Free PMC article.
B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cells.
Carolin Brandl, Sonja Ortler, +3 authors, Heinz Wiendl.
PLoS One, 2010 Jun 04; 5(5). PMID: 20520738    Free PMC article.
Unexpected acceleration of type 1 diabetes by transgenic expression of B7-H1 in NOD mouse peri-islet glia.
Jason Yantha, Hubert Tsui, +5 authors, H-Michael Dosch.
Diabetes, 2010 Jun 05; 59(10). PMID: 20522597    Free PMC article.
Plasticity in programming of effector and memory CD8 T-cell formation.
Ramon Arens, Stephen P Schoenberger.
Immunol Rev, 2010 Jun 12; 235(1). PMID: 20536564    Free PMC article.
Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma.
Guoqiang Li, Xiaofeng Wu, +7 authors, Xuehao Wang.
J Cancer Res Clin Oncol, 2010 Jun 22; 137(4). PMID: 20563597
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Tomohiro Fukaya, Hideaki Takagi, +10 authors, Katsuaki Sato.
Blood, 2010 Jun 25; 116(13). PMID: 20574047    Free PMC article.
PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.
Marguerite Ghiotto, Laurent Gauthier, +4 authors, Daniel Olive.
Int Immunol, 2010 Jul 01; 22(8). PMID: 20587542    Free PMC article.
Cancer-associated myeloproliferation: old association, new therapeutic target.
Ryan A Wilcox.
Mayo Clin Proc, 2010 Jul 02; 85(7). PMID: 20592171    Free PMC article.
Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.
Eszter Lázár-Molnár, Bing Chen, +7 authors, William R Jacobs.
Proc Natl Acad Sci U S A, 2010 Jul 14; 107(30). PMID: 20624978    Free PMC article.
Highly Cited.
Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects.
Myriam N Bouchlaka, Doug Redelman, William J Murphy.
Immunotherapy, 2010 Jul 20; 2(3). PMID: 20635904    Free PMC article.
Dual roles for immunity in gastrointestinal cancers.
Cristina Ferrone, Glenn Dranoff.
J Clin Oncol, 2010 Jul 21; 28(26). PMID: 20644090    Free PMC article.
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.
Celine S Lages, Ian Lewkowich, +2 authors, Claire Chougnet.
Aging Cell, 2010 Jul 27; 9(5). PMID: 20653631    Free PMC article.
Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection.
Afework Kassu, Roland A Marcus, +6 authors, Brent E Palmer.
J Immunol, 2010 Jul 27; 185(5). PMID: 20656923    Free PMC article.
Separate roles for antigen recognition and lymph node inflammation in CD8+ memory T cell formation.
Marieke F Fransen, Marianne J van Stipdonk, +3 authors, Rienk Offringa.
J Immunol, 2010 Aug 11; 185(6). PMID: 20696863    Free PMC article.
CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis.
Maíra Felonato, Adriana Pina, +3 authors, Vera L G Calich.
Infect Immun, 2010 Aug 18; 78(11). PMID: 20713624    Free PMC article.
Increased programmed death-1 expression on CD4+ T cells in cutaneous T-cell lymphoma: implications for immune suppression.
Sara Samimi, Bernice Benoit, +4 authors, Alain H Rook.
Arch Dermatol, 2010 Aug 18; 146(12). PMID: 20713771    Free PMC article.
IAP inhibitors enhance co-stimulation to promote tumor immunity.
Michael Dougan, Stephanie Dougan, +11 authors, Glenn Dranoff.
J Exp Med, 2010 Sep 15; 207(10). PMID: 20837698    Free PMC article.
T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells.
Judith Leitner, Werner Kuschei, +6 authors, Peter Steinberger.
J Immunol Methods, 2010 Sep 23; 362(1-2). PMID: 20858499    Free PMC article.
The pathogenesis of sepsis.
Deborah J Stearns-Kurosawa, Marcin F Osuchowski, +2 authors, Daniel G Remick.
Annu Rev Pathol, 2010 Oct 05; 6. PMID: 20887193    Free PMC article.
Highly Cited. Review.
Respiratory syncytial virus is associated with an inflammatory response in lungs and architectural remodeling of lung-draining lymph nodes of newborn lambs.
Fatoumata B Sow, Jack M Gallup, +4 authors, Mark R Ackermann.
Am J Physiol Lung Cell Mol Physiol, 2010 Oct 12; 300(1). PMID: 20935230    Free PMC article.
Co-stimulation blockade as a new strategy in kidney transplantation: benefits and limits.
Renaud Snanoudj, Julien Zuber, Christophe Legendre.
Drugs, 2010 Oct 23; 70(16). PMID: 20964456
B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence.
Ramon Arens, Andrea Loewendorf, +6 authors, Chris A Benedict.
J Virol, 2010 Oct 29; 85(1). PMID: 20980516    Free PMC article.
The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.
Chrystal M Paulos, Carmine Carpenito, +6 authors, Carl H June.
Sci Transl Med, 2010 Oct 29; 2(55). PMID: 20980695    Free PMC article.
Highly Cited.
Designing vaccines based on biology of human dendritic cell subsets.
Karolina Palucka, Jacques Banchereau, Ira Mellman.
Immunity, 2010 Oct 30; 33(4). PMID: 21029958    Free PMC article.
Highly Cited. Review.
Current progress in γδ T-cell biology.
Jianlei Hao, Xiaoli Wu, +7 authors, Zhinan Yin.
Cell Mol Immunol, 2010 Nov 03; 7(6). PMID: 21042298    Free PMC article.
B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.
Keith M Hamel, Yanxia Cao, +4 authors, Alison Finnegan.
Eur J Immunol, 2010 Nov 10; 40(11). PMID: 21061440    Free PMC article.
Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo.
N M Rogers, S Kireta, P T H Coates.
Clin Exp Immunol, 2010 Nov 13; 162(3). PMID: 21070208    Free PMC article.
PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients.
Tao Shen, Jiajia Zheng, +4 authors, Hui Zhuang.
Virol J, 2010 Nov 13; 7. PMID: 21070674    Free PMC article.
The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs.
Shannon J Turley, Anne L Fletcher, Kutlu G Elpek.
Nat Rev Immunol, 2010 Nov 20; 10(12). PMID: 21088682
Intracellular B7-H4 suppresses bile duct epithelial cell apoptosis in human primary biliary cirrhosis.
Yongwen Chen, Guoning Guo, +4 authors, Yuzhang Wu.
Inflammation, 2010 Dec 02; 34(6). PMID: 21120594
B7-h3 and its role in antitumor immunity.
Martin Loos, Dennis M Hedderich, Helmut Friess, Jörg Kleeff.
Clin Dev Immunol, 2010 Dec 04; 2010. PMID: 21127709    Free PMC article.
Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.
Paolo Fiorina, Mollie Jurewicz, +15 authors, Reza Abdi.
J Immunol, 2010 Dec 07; 186(1). PMID: 21131428    Free PMC article.
Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy.
Marcus R Clark, Azusa Tanaka, Sarah E Powers, Margaret Veselits.
Mol Immunol, 2010 Dec 15; 48(11). PMID: 21144589    Free PMC article.
Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.
Chao Yu, Andreas F-P Sonnen, +9 authors, Simon J Davis.
J Biol Chem, 2010 Dec 16; 286(8). PMID: 21156796    Free PMC article.
A dimeric structure of PD-L1: functional units or evolutionary relics?
Yong Chen, Peipei Liu, +3 authors, George F Gao.
Protein Cell, 2011 Jan 05; 1(2). PMID: 21203985    Free PMC article.
SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells.
Madhumouli Chatterjee, Katalin Kis-Toth, +2 authors, George C Tsokos.
Autoimmunity, 2011 Jan 15; 44(3). PMID: 21231893    Free PMC article.
The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation.
Michael H Shaw, Nobuhiko Kamada, +2 authors, Gabriel Nuñez.
Trends Immunol, 2011 Jan 22; 32(2). PMID: 21251876    Free PMC article.
DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability.
Tina L Sumpter, Vignesh Packiam, +3 authors, Angus W Thomson.
J Immunol, 2011 Jan 25; 186(4). PMID: 21257958    Free PMC article.
Human thymic stromal lymphopoietin enhances expression of CD80 in human CD14+ monocytes/macrophages.
Reiji Hirano, Shunji Hasegawa, +3 authors, Takashi Ichiyama.
Inflamm Res, 2011 Jan 29; 60(6). PMID: 21274737
Programmed death ligand 2 regulates arginase induction and modifies Trypanosoma cruzi survival in macrophages during murine experimental infection.
Laura R Dulgerian, Vanina V Garrido, Cinthia C Stempin, Fabio M Cerbán.
Immunology, 2011 Feb 10; 133(1). PMID: 21303364    Free PMC article.
Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity.
Tracey L Papenfuss, Nicole D Powell, +5 authors, Caroline C Whitacre.
J Immunol, 2011 Feb 15; 186(6). PMID: 21317386    Free PMC article.
Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4.
Karine Botturi, Yannick Lacoeuille, +2 authors, Antoine Magnan.
Respir Res, 2011 Mar 02; 12. PMID: 21356099    Free PMC article.
Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.
Ramon Arens, Andrea Loewendorf, +5 authors, Stephen P Schoenberger.
J Immunol, 2011 Mar 02; 186(7). PMID: 21357256    Free PMC article.
Immunologic functions as prognostic indicators in melanoma.
Marna G Bouwhuis, Timo L M ten Hagen, Alexander M M Eggermont.
Mol Oncol, 2011 Mar 04; 5(2). PMID: 21367679    Free PMC article.
Dose-dependent effect of anti-CTLA-4 on survival in sepsis.
Shigeaki Inoue, Lulong Bo, +3 authors, Richard S Hotchkiss.
Shock, 2011 Mar 04; 36(1). PMID: 21368717    Free PMC article.
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
Vstm3 is a member of the CD28 family and an important modulator of T-cell function.
Steven D Levin, David W Taft, +21 authors, Katherine E Lewis.
Eur J Immunol, 2011 Mar 19; 41(4). PMID: 21416464    Free PMC article.
A novel function for programmed death ligand-1 regulation of angiogenesis.
Yiping Jin, Sunil K Chauhan, +4 authors, Reza Dana.
Am J Pathol, 2011 Mar 26; 178(4). PMID: 21435468    Free PMC article.
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
Arne N Akbar, Sian M Henson.
Nat Rev Immunol, 2011 Mar 26; 11(4). PMID: 21436838
Highly Cited.
IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
E B Ahmed, T Wang, +2 authors, A S Chong.
Am J Transplant, 2011 Apr 01; 11(5). PMID: 21449942    Free PMC article.
Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells.
Ho-Keun Kwon, Ji-Sun Hwang, +8 authors, Sin-Hyeog Im.
World J Gastroenterol, 2011 Apr 01; 17(8). PMID: 21451725    Free PMC article.
Molecular mechanisms of T-cell tolerance.
Roza I Nurieva, Xindong Liu, Chen Dong.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488895    Free PMC article.
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Jeffrey A Bluestone.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898    Free PMC article.
Highly Cited. Review.
CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease.
D'Anne S Duncan, Stephen D Miller.
PLoS One, 2011 Apr 16; 6(4). PMID: 21494618    Free PMC article.
Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis.
Bechara Mfarrej, Mary Keir, +4 authors, Indira Guleria.
Clin Immunol, 2011 Apr 19; 140(1). PMID: 21498129    Free PMC article.
Cell surface signaling molecules in the control of immune responses: a tide model.
Yuwen Zhu, Sheng Yao, Lieping Chen.
Immunity, 2011 Apr 23; 34(4). PMID: 21511182    Free PMC article.
Ambivalent role of the innate immune response in rabies virus pathogenesis.
Damien Chopy, Julien Pothlichet, +4 authors, Monique Lafon.
J Virol, 2011 Apr 29; 85(13). PMID: 21525357    Free PMC article.
Cytotoxic T lymphocyte antigen 4 immunoglobulin modified dendritic cells attenuate allergic airway inflammation and hyperresponsiveness by regulating the development of T helper type 1 (Th1)/Th2 and Th2/regulatory T cell subsets in a murine model of asthma.
L Ying, Z Fu, +4 authors, E Liu.
Clin Exp Immunol, 2011 May 07; 165(1). PMID: 21545583    Free PMC article.
Inverse correlation of programmed death 1 (PD-1) expression in T cells to the spinal radiologic changes in Taiwanese patients with ankylosing spondylitis.
Ming-Han Chen, Wei-Sheng Chen, +2 authors, Chung-Tei Chou.
Clin Rheumatol, 2011 May 07; 30(9). PMID: 21547439
Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS).
Elizabeth J Hager, Jon D Piganelli, Hubert M Tse, K Michael Gibson.
J Inherit Metab Dis, 2011 May 25; 35(1). PMID: 21607759    Free PMC article.
Costimulatory pathways in transplantation.
Nina Pilat, Mohamed H Sayegh, Thomas Wekerle.
Semin Immunol, 2011 May 28; 23(4). PMID: 21616680    Free PMC article.
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Filippos Porichis, Douglas S Kwon, +9 authors, Daniel E Kaufmann.
Blood, 2011 Jun 10; 118(4). PMID: 21652684    Free PMC article.
Highly Cited.
CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting B cells.
Shweta Jain, Sathi Babu Chodisetti, Javed N Agrewala.
PLoS One, 2011 Jun 16; 6(6). PMID: 21674065    Free PMC article.
CD8 T Cells and Toxoplasma gondii: A New Paradigm.
Jason P Gigley, Rajarshi Bhadra, Imtiaz A Khan.
J Parasitol Res, 2011 Jun 21; 2011. PMID: 21687650    Free PMC article.
Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection.
Jason P Gigley, Imtiaz A Khan.
PLoS One, 2011 Jun 23; 6(6). PMID: 21695169    Free PMC article.
T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract.
Binfeng Lu, Lujun Chen, +4 authors, Xueguang Zhang.
Immunol Res, 2011 Jul 01; 50(2-3). PMID: 21717068
Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
Joyce Wei, P'ng Loke, Xingxing Zang, James P Allison.
J Exp Med, 2011 Jul 06; 208(8). PMID: 21727190    Free PMC article.
The immunology of stroke: from mechanisms to translation.
Costantino Iadecola, Josef Anrather.
Nat Med, 2011 Jul 09; 17(7). PMID: 21738161    Free PMC article.
Highly Cited. Review.
The effects of Cyclosporine A and azathioprine on human T cells activated by different costimulatory signals.
Judith Leitner, Karin Drobits, +3 authors, Peter Steinberger.
Immunol Lett, 2011 Jul 16; 140(1-2). PMID: 21756939    Free PMC article.
Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.
Dallas B Flies, Shengdian Wang, Haiying Xu, Lieping Chen.
J Immunol, 2011 Jul 20; 187(4). PMID: 21768399    Free PMC article.
B and T lymphocyte attenuator regulates the development of antigen-induced experimental conjunctivitis.
Waka Ishida, Ken Fukuda, +4 authors, Atsuki Fukushima.
Graefes Arch Clin Exp Ophthalmol, 2011 Jul 23; 250(2). PMID: 21779950
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated disruption of the CD40 ligand-induced activation of primary human B cells.
Haitian Lu, Robert B Crawford, Barbara L F Kaplan, Norbert E Kaminski.
Toxicol Appl Pharmacol, 2011 Aug 03; 255(3). PMID: 21807014    Free PMC article.
Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani.
Rashmi Bankoti, Simona Stäger.
J Trop Med, 2011 Aug 04; 2012. PMID: 21811511    Free PMC article.
Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells.
Günther Baravalle, Hyesuk Park, +4 authors, Jeoung-Sook Shin.
J Immunol, 2011 Aug 19; 187(6). PMID: 21849678    Free PMC article.
B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors.
Tomonori Kaifu, Bertrand Escalière, +2 authors, Myriam Baratin.
Cell Mol Life Sci, 2011 Aug 31; 68(21). PMID: 21877119
T cell costimulation and coinhibition: genetics and disease.
Lisa Scandiuzzi, Kaya Ghosh, Xingxing Zang.
Discov Med, 2011 Sep 01; 12(63). PMID: 21878189    Free PMC article.
Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells.
Nicole L Yonkers, Benigno Rodriguez, +2 authors, Donald D Anthony.
PLoS One, 2011 Sep 14; 6(9). PMID: 21912648    Free PMC article.
Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade.
Wen Li, William R Green.
J Virol, 2011 Sep 16; 85(24). PMID: 21917983    Free PMC article.
Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production.
Shintaro Maeda, Manabu Fujimoto, +3 authors, Minoru Hasegawa.
Am J Pathol, 2011 Sep 20; 179(5). PMID: 21925472    Free PMC article.
Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock.
Gila Arad, Revital Levy, +7 authors, Raymond Kaempfer.
PLoS Biol, 2011 Sep 21; 9(9). PMID: 21931534    Free PMC article.
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.
Ben Youngblood, Kenneth J Oestreich, +9 authors, Rafi Ahmed.
Immunity, 2011 Sep 29; 35(3). PMID: 21943489    Free PMC article.
Highly Cited.
Targeting mucosal immunity in the battle to develop a mastitis vaccine.
Mini Bharathan, Isis K Mullarky.
J Mammary Gland Biol Neoplasia, 2011 Oct 05; 16(4). PMID: 21968537
Tolerogen-induced interferon-producing killer dendritic cells (IKDCs) protect against EAE.
Eduardo Huarte, Agnieszka Rynda-Apple, +7 authors, David W Pascual.
J Autoimmun, 2011 Oct 25; 37(4). PMID: 22018711    Free PMC article.
The regulation and role of T follicular helper cells in immunity.
Elissa K Deenick, Cindy S Ma.
Immunology, 2011 Nov 03; 134(4). PMID: 22043829    Free PMC article.
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma.
Xiang-Yang Wang, Daming Zuo, Devanand Sarkar, Paul B Fisher.
Expert Opin Pharmacother, 2011 Nov 15; 12(17). PMID: 22077831    Free PMC article.
Role of co-stimulation in Leishmaniasis.
Rashmi Tuladhar, Gayathri Natarajan, Abhay R Satoskar.
Int J Biol Sci, 2011 Nov 24; 7(9). PMID: 22110389    Free PMC article.
Ontogeny of the immune response in the ovine lung.
Fatoumata B Sow, Jack M Gallup, +2 authors, Mark R Ackermann.
Immunol Invest, 2011 Nov 30; 41(3). PMID: 22122502    Free PMC article.
Regulation of immune responses by mTOR.
Jonathan D Powell, Kristen N Pollizzi, Emily B Heikamp, Maureen R Horton.
Annu Rev Immunol, 2011 Dec 06; 30. PMID: 22136167    Free PMC article.
Highly Cited. Review.
The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain.
Swadhinya Arjunaraja, Paola Massari, +3 authors, Clifford M Snapper.
J Immunol, 2011 Dec 14; 188(2). PMID: 22156342    Free PMC article.
Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity.
Jens Eberlein, Bennett Davenport, +3 authors, Dirk Homann.
J Virol, 2011 Dec 14; 86(4). PMID: 22156513    Free PMC article.
Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.
Dallas B Flies, Britt J Sandler, Mario Sznol, Lieping Chen.
Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180678    Free PMC article.
Role of PD-1 in HIV pathogenesis and as target for therapy.
Filippos Porichis, Daniel E Kaufmann.
Curr HIV/AIDS Rep, 2011 Dec 27; 9(1). PMID: 22198819    Free PMC article.
Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade.
Sian M Henson, Richard Macaulay, Ornella Franzese, Arne N Akbar.
Immunology, 2012 Jan 04; 135(4). PMID: 22211948    Free PMC article.
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Curr Opin Immunol, 2012 Jan 13; 24(2). PMID: 22236695    Free PMC article.
Highly Cited. Review.
Tissue biomarkers for prostate cancer radiation therapy.
P T Tran, R K Hales, +10 authors, T L DeWeese.
Curr Mol Med, 2012 Feb 02; 12(6). PMID: 22292443    Free PMC article.
Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81.
Yael Sagi, Angela Landrigan, Ronald Levy, Shoshana Levy.
Proc Natl Acad Sci U S A, 2012 Feb 07; 109(5). PMID: 22307619    Free PMC article.
CD4 and CD8 T cells require different membrane gangliosides for activation.
Masakazu Nagafuku, Kaori Okuyama, +8 authors, Jin-ichi Inokuchi.
Proc Natl Acad Sci U S A, 2012 Feb 07; 109(6). PMID: 22308377    Free PMC article.
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.
Julius Clemence R Hafalla, Carla Claser, +4 authors, Eleanor M Riley.
PLoS Pathog, 2012 Feb 10; 8(2). PMID: 22319445    Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy.
Drew Pardoll, Charles Drake.
J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682    Free PMC article.
CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.
Tomoyuki Shimazu, Ryuji Iida, +4 authors, Paul W Kincade.
Blood, 2012 Mar 01; 119(21). PMID: 22371880    Free PMC article.
Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape.
Jung Joo Hong, Praveen K Amancha, +2 authors, Francois Villinger.
J Immunol, 2012 Mar 06; 188(7). PMID: 22387550    Free PMC article.
Highly Cited.
Immunity, cancer and aging: lessons from mouse models.
Cheryl E Myers, Noweeda N Mirza, Joseph Lustgarten.
Aging Dis, 2012 Mar 08; 2(6). PMID: 22396898    Free PMC article.
Pancreatic ductal adenocarcinoma: a review of immunologic aspects.
Megan B Wachsmann, Laurentiu M Pop, Ellen S Vitetta.
J Investig Med, 2012 Mar 13; 60(4). PMID: 22406516    Free PMC article.
B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma.
Dong Hua, Jing Sun, +3 authors, Xue-Guang Zhang.
World J Gastroenterol, 2012 Mar 13; 18(9). PMID: 22408358    Free PMC article.
B effector cells in rheumatoid arthritis and experimental arthritis.
Alison Finnegan, Susan Ashaye, Keith M Hamel.
Autoimmunity, 2012 Mar 22; 45(5). PMID: 22432771    Free PMC article.
Combining immunotherapy and targeted therapies in cancer treatment.
Matthew Vanneman, Glenn Dranoff.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437869    Free PMC article.
Highly Cited. Review.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells.
Thomas Duhen, Rebekka Duhen, +2 authors, Daniel J Campbell.
Blood, 2012 Mar 23; 119(19). PMID: 22438251    Free PMC article.
Highly Cited.
Functional interaction of CD154 protein with α5β1 integrin is totally independent from its binding to αIIbβ3 integrin and CD40 molecules.
Youssef El Fakhry, Haydar Alturaihi, +9 authors, Walid Mourad.
J Biol Chem, 2012 Mar 31; 287(22). PMID: 22461623    Free PMC article.
CD4⁺T cells: differentiation and functions.
Rishi Vishal Luckheeram, Rui Zhou, Asha Devi Verma, Bing Xia.
Clin Dev Immunol, 2012 Apr 05; 2012. PMID: 22474485    Free PMC article.
Highly Cited. Review.
Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC.
Martin F Flajnik, Tereza Tlapakova, +2 authors, Yuko Ohta.
Immunogenetics, 2012 Apr 11; 64(8). PMID: 22488247    Free PMC article.
Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway.
Sheng Xu, Xingguang Liu, +6 authors, Xuetao Cao.
Nat Immunol, 2012 Apr 24; 13(6). PMID: 22522491
CD28 ligation increases macrophage suppression of T-cell proliferation.
Daniel Silberman, Amanda Bucknum, +8 authors, James E Riggs.
Cell Mol Immunol, 2012 Apr 24; 9(4). PMID: 22522653    Free PMC article.
Structurally identical capsular polysaccharide expressed by intact group B streptococcus versus Streptococcus pneumoniae elicits distinct murine polysaccharide-specific IgG responses in vivo.
Swadhinya Arjunaraja, Lawrence C Paoletti, Clifford M Snapper.
J Immunol, 2012 Apr 24; 188(11). PMID: 22523389    Free PMC article.
Positive and negative regulation of cellular immune responses in physiologic conditions and diseases.
S Viganò, M Perreau, G Pantaleo, A Harari.
Clin Dev Immunol, 2012 May 02; 2012. PMID: 22548114    Free PMC article.
Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells.
Stéphane Chevrier, Céline Genton, +2 authors, Hans Acha-Orbea.
Front Immunol, 2012 May 09; 3. PMID: 22566911    Free PMC article.
The role of coinhibitory signaling pathways in transplantation and tolerance.
Martina M McGrath, Nader Najafian.
Front Immunol, 2012 May 09; 3. PMID: 22566929    Free PMC article.
Protocadherin-18 is a novel differentiation marker and an inhibitory signaling receptor for CD8+ effector memory T cells.
Edwin J Vazquez-Cintron, Ngozi R Monu, +6 authors, Alan B Frey.
PLoS One, 2012 May 09; 7(5). PMID: 22567129    Free PMC article.
Immunotherapy of cancer in 2012.
John M Kirkwood, Lisa H Butterfield, +3 authors, Soldano Ferrone.
CA Cancer J Clin, 2012 May 12; 62(5). PMID: 22576456    Free PMC article.
Highly Cited. Review.
B7h-expressing dendritic cells and plasma B cells mediate distinct outcomes of ICOS costimulation in T cell-dependent antibody responses.
Kevin Larimore, Linda Liang, Sonia Bakkour, William C Sha.
BMC Immunol, 2012 Jun 13; 13. PMID: 22686515    Free PMC article.
Dynamic education of macrophages in different areas of human tumors.
Yan Wu, Limin Zheng.
Cancer Microenviron, 2012 Jun 15; 5(3). PMID: 22696271    Free PMC article.
Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice.
Roham Parsa, Pernilla Andresen, +5 authors, Robert A Harris.
Diabetes, 2012 Jun 30; 61(11). PMID: 22745325    Free PMC article.
NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer.
Foluso O Ademuyiwa, Wiam Bshara, +12 authors, Kunle Odunsi.
PLoS One, 2012 Jul 05; 7(6). PMID: 22761704    Free PMC article.
Immunoregulatory molecules are master regulators of inflammation during the immune response.
Hortensia de la Fuente, Danay Cibrián, Francisco Sánchez-Madrid.
FEBS Lett, 2012 Jul 24; 586(18). PMID: 22819828    Free PMC article.
CD86 gene variants and susceptibility to pancreatic cancer.
Honggang Xiang, Wei Zhao, +8 authors, Zhiqian Hu.
J Cancer Res Clin Oncol, 2012 Jul 24; 138(12). PMID: 22821131
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Aparna Palakodeti, Andrew Sandstrom, +6 authors, Erin J Adams.
J Biol Chem, 2012 Aug 01; 287(39). PMID: 22846996    Free PMC article.
Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread.
Robert L Ferris, Michael T Lotze, +2 authors, Donald L Morton.
Clin Exp Metastasis, 2012 Aug 02; 29(7). PMID: 22851005    Free PMC article.
Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection.
Kimberly A Hofmeyer, Lisa Scandiuzzi, +2 authors, Xingxing Zang.
J Immunol, 2012 Aug 03; 189(6). PMID: 22855708    Free PMC article.
The darker side of follicular helper T cells: from autoimmunity to immunodeficiency.
Sudhanshu Shekhar, Xi Yang.
Cell Mol Immunol, 2012 Aug 14; 9(5). PMID: 22885524    Free PMC article.
CpG-ODN-induced sustained expression of BTLA mediating selective inhibition of human B cells.
Marie-Laure Thibult, Jean-Paul Rivals, +5 authors, Daniel Olive.
J Mol Med (Berl), 2012 Aug 21; 91(2). PMID: 22903545
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.
Jonathan M Han, Scott J Patterson, Megan K Levings.
Front Immunol, 2012 Aug 21; 3. PMID: 22905034    Free PMC article.
CD28-B7 interaction modulates short- and long-lived plasma cell function.
Modesta N Njau, Jin Hyang Kim, +4 authors, Joshy Jacob.
J Immunol, 2012 Aug 22; 189(6). PMID: 22908331    Free PMC article.
The molecular signature of tissue resident memory CD8 T cells isolated from the brain.
Linda M Wakim, Amanda Woodward-Davis, +4 authors, Michael J Bevan.
J Immunol, 2012 Aug 28; 189(7). PMID: 22922816    Free PMC article.
Highly Cited.
Therese Liechtenstein, Ines Dufait, +2 authors, David Escors.
Immunol Endocr Metab Agents Med Chem, 2012 Sep 05; 12(3). PMID: 22945252    Free PMC article.
Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?
Philippa Marrack, John W Kappler.
Cold Spring Harb Perspect Med, 2012 Sep 07; 2(9). PMID: 22951444    Free PMC article.
Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients.
Serena S Kwek, Vinh Dao, +5 authors, Lawrence Fong.
J Immunol, 2012 Sep 08; 189(7). PMID: 22956585    Free PMC article.
CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells.
Felix S Lichtenegger, Katharina Mueller, +4 authors, Marion Subklewe.
PLoS One, 2012 Sep 11; 7(9). PMID: 22962607    Free PMC article.
Enhancement of membrane B7-H3 costimulatory molecule but reduction of its soluble form in multiple sclerosis.
Juean Jiang, Jianhua Jiang, +8 authors, Qun Xue.
J Clin Immunol, 2012 Sep 22; 33(1). PMID: 22996270
Coinhibitory molecules in autoimmune diseases.
Norihiko Watanabe, Hiroshi Nakajima.
Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525    Free PMC article.
The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response.
Hassnae Afrache, Philippe Gouret, +2 authors, Daniel Olive.
Immunogenetics, 2012 Sep 25; 64(11). PMID: 23000944
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.
Yuning Lu, Helga Schneider, Christopher E Rudd.
Blood, 2012 Oct 11; 120(23). PMID: 23047820    Free PMC article.
Introduction to the use of belatacept: a fusion protein for the prevention of posttransplant kidney rejection.
Giovanbattista Ippoliti, Andrea Maria D'Armini, +2 authors, Mario Viganò.
Biologics, 2012 Oct 12; 6. PMID: 23055693    Free PMC article.
[Immunotherapy of melanomas].
L Zimmer, J Vaubel, D Schadendorf.
Hautarzt, 2012 Oct 26; 63(12). PMID: 23097082
Harnessing DNA-induced immune responses for improving cancer vaccines.
Andrés A Herrada, Nicole Rojas-Colonelli, +4 authors, Alvaro Lladser.
Hum Vaccin Immunother, 2012 Nov 01; 8(11). PMID: 23111166    Free PMC article.
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
Lanfen Chen, Zhangguo Chen, +19 authors, Richard S Blumberg.
Immunity, 2012 Nov 06; 37(5). PMID: 23123061    Free PMC article.
Investigation of CD28 gene polymorphisms in patients with sporadic breast cancer in a Chinese Han population in Northeast China.
Shuang Chen, Qing Zhang, +7 authors, Dianjun Li.
PLoS One, 2012 Nov 08; 7(10). PMID: 23133541    Free PMC article.
The Presence of Anti-HLA Antibodies before and after Allogeneic Hematopoietic Stem Cells Transplantation from HLA-Mismatched Unrelated Donors.
Anna Koclega, Miroslaw Markiewicz, +7 authors, Slawomira Kyrcz-Krzemien.
Bone Marrow Res, 2012 Nov 15; 2012. PMID: 23150827    Free PMC article.
Differential capacity of human skin dendritic cells to polarize CD4+ T cells into IL-17, IL-21 and IL-22 producing cells.
Karine Penel-Sotirakis, Elise Simonazzi, Josette Péguet-Navarro, Aurore Rozières.
PLoS One, 2012 Dec 12; 7(11). PMID: 23226194    Free PMC article.
Heterogeneity of gangliosides among T cell subsets.
Jin-ichi Inokuchi, Masakazu Nagafuku, Isao Ohno, Akemi Suzuki.
Cell Mol Life Sci, 2012 Dec 13; 70(17). PMID: 23233133
Augmentation of hepatitis B virus-specific cellular immunity with programmed death receptor-1/programmed death receptor-L1 blockade in hepatitis B virus and HIV/hepatitis B virus coinfected patients treated with adefovir.
Amy C Sherman, Nirupama Trehanpati, +5 authors, Anita Kohli.
AIDS Res Hum Retroviruses, 2012 Dec 25; 29(4). PMID: 23259453    Free PMC article.
Local and systemic effects of co-stimulatory blockade using cytotoxic T lymphocyte antigen-4-immunoglobulin in dinitrofluorobenzene- and oxazolone-induced contact hypersensitivity in mice.
A D Christensen, S Skov, C Haase.
Clin Exp Immunol, 2013 Jan 05; 171(2). PMID: 23286949    Free PMC article.
Targeting the B7 family of co-stimulatory molecules: successes and challenges.
Joseph R Podojil, Stephen D Miller.
BioDrugs, 2013 Jan 19; 27(1). PMID: 23329394    Free PMC article.
Molecular control of steady-state dendritic cell maturation and immune homeostasis.
Gianna Elena Hammer, Averil Ma.
Annu Rev Immunol, 2013 Jan 22; 31. PMID: 23330953    Free PMC article.
Adenovirus expressing both thymidine kinase and soluble PD1 enhances antitumor immunity by strengthening CD8 T-cell response.
Seung-Pil Shin, Hye-Hyun Seo, +7 authors, Sang-Jin Lee.
Mol Ther, 2013 Jan 23; 21(3). PMID: 23337984    Free PMC article.
CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs.
Pablo A Romagnoli, Mary F Premenko-Lanier, Gilbert D Loria, John D Altman.
PLoS One, 2013 Feb 27; 8(2). PMID: 23441229    Free PMC article.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Lieping Chen, Dallas B Flies.
Nat Rev Immunol, 2013 Mar 09; 13(4). PMID: 23470321    Free PMC article.
Highly Cited. Review.
B7-H3 associated with tumor progression and epigenetic regulatory activity in cutaneous melanoma.
Jinhua Wang, Kelly K Chong, +7 authors, Dave S B Hoon.
J Invest Dermatol, 2013 Mar 12; 133(8). PMID: 23474948    Free PMC article.
Molecular signatures of T-cell inhibition in HIV-1 infection.
Marie Larsson, Esaki M Shankar, +5 authors, Adeeba Kamarulzaman.
Retrovirology, 2013 Mar 22; 10. PMID: 23514593    Free PMC article.
Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia.
Wen Yang, Yan Song, +2 authors, Hong-Wei Wang.
Immunology, 2013 Mar 26; 139(4). PMID: 23521696    Free PMC article.
PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal.
Therese Liechtenstein, Ines Dufait, +4 authors, David Escors.
J Clin Cell Immunol, 2013 Mar 26; S12. PMID: 23525238    Free PMC article.
Rhesus macaque lymph node PD-1(hi)CD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7(lo)ICOS+Bcl6+ T-follicular helper (Tfh) cell phenotype.
Olusegun O Onabajo, Jeffy George, Mark G Lewis, Joseph J Mattapallil.
PLoS One, 2013 Mar 26; 8(3). PMID: 23527264    Free PMC article.
Alteration of the thymic T cell repertoire by rotavirus infection is associated with delayed type 1 diabetes development in non-obese diabetic mice.
Nicole L Webster, Christel Zufferey, Jessica A Pane, Barbara S Coulson.
PLoS One, 2013 Apr 05; 8(3). PMID: 23554993    Free PMC article.
Potentiating functional antigen-specific CD8⁺ T cell immunity by a novel PD1 isoform-based fusion DNA vaccine.
Jingying Zhou, Allen Kl Cheung, +7 authors, Zhiwei Chen.
Mol Ther, 2013 Apr 17; 21(7). PMID: 23587922    Free PMC article.
The role of programmed cell death ligand-1 (PD-L1/CD274) in the development of graft versus host disease.
Heevy Al-Chaqmaqchi, Behnam Sadeghi, +6 authors, Ali Moshfegh.
PLoS One, 2013 Apr 18; 8(4). PMID: 23593203    Free PMC article.
Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivo.
S Yasuda, M Sho, +5 authors, Y Nakajima.
Clin Exp Immunol, 2013 Apr 23; 172(3). PMID: 23600839    Free PMC article.
Strength of PD-1 signaling differentially affects T-cell effector functions.
Fang Wei, Shi Zhong, +6 authors, James L Riley.
Proc Natl Acad Sci U S A, 2013 Apr 24; 110(27). PMID: 23610399    Free PMC article.
Highly Cited.
T-cell tolerance in cancer.
Roza Nurieva, Junmei Wang, Anupama Sahoo.
Immunotherapy, 2013 May 04; 5(5). PMID: 23638746    Free PMC article.
Optimal management of metastatic melanoma: current strategies and future directions.
Marta Batus, Salman Waheed, +3 authors, Howard L Kaufman.
Am J Clin Dermatol, 2013 May 17; 14(3). PMID: 23677693    Free PMC article.
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.
Joseph R Podojil, Linda N Liu, +5 authors, Stephen D Miller.
J Autoimmun, 2013 May 21; 44. PMID: 23683881    Free PMC article.
Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes.
Takuji Ishimoto, Gabriel Cara-Fuentes, +9 authors, Eduardo H Garin.
Pediatr Nephrol, 2013 May 22; 28(9). PMID: 23689904    Free PMC article.
Serum LAIR-2 is increased in autoimmune thyroid diseases.
Rita Simone, Giampaola Pesce, +3 authors, Daniele Saverino.
PLoS One, 2013 May 22; 8(5). PMID: 23691008    Free PMC article.
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
Ruihua Zhao, Jordan M Chinai, +8 authors, Xingxing Zang.
Proc Natl Acad Sci U S A, 2013 May 30; 110(24). PMID: 23716685    Free PMC article.
Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells.
Tatjana Nikolic, Bart O Roep.
Front Immunol, 2013 May 30; 4. PMID: 23717310    Free PMC article.
Suppression by Δ(9)-tetrahydrocannabinol of the primary immunoglobulin M response by human peripheral blood B cells is associated with impaired STAT3 activation.
Thitirat Ngaotepprutaram, Barbara L F Kaplan, +2 authors, Norbert E Kaminski.
Toxicology, 2013 Jun 04; 310. PMID: 23727458    Free PMC article.
Generation and characterization of two novel monoclonal antibodies produced against human TLT-2 molecule.
Jun-Chi Xu, Fei Gao, +4 authors, Xue-Guang Zhang.
Monoclon Antib Immunodiagn Immunother, 2013 Jun 12; 32(3). PMID: 23750481    Free PMC article.
Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway.
Ronald Charles, Hong-Shiue Chou, +3 authors, Shiguang Qian.
Transplantation, 2013 Jun 13; 96(1). PMID: 23756770    Free PMC article.
Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates.
M B Ezzelarab, A F Zahorchak, +10 authors, A W Thomson.
Am J Transplant, 2013 Jun 14; 13(8). PMID: 23758811    Free PMC article.
Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand-1 surface expression.
Wanlu Lu, Libing Lu, +7 authors, Ping Zhang.
Oncol Lett, 2013 Jun 14; 5(5). PMID: 23761816    Free PMC article.
Molecular profiling of tumor-specific TH1 cells activated in vivo.
Kristina Berg Lorvik, Ole Audun Werner Haabeth, +2 authors, Alexandre Corthay.
Oncoimmunology, 2013 Jun 14; 2(5). PMID: 23762808    Free PMC article.
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
Ben Youngblood, Alessandra Noto, +14 authors, Daniel E Kaufmann.
J Immunol, 2013 Jun 19; 191(2). PMID: 23772031    Free PMC article.
Highly Cited.
B7-H5 costimulates human T cells via CD28H.
Yuwen Zhu, Sheng Yao, +13 authors, Lieping Chen.
Nat Commun, 2013 Jun 21; 4. PMID: 23784006    Free PMC article.
Molecular insights for optimizing T cell receptor specificity against cancer.
Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer.
Front Immunol, 2013 Jun 27; 4. PMID: 23801991    Free PMC article.
Cancer vaccines: Looking to the future.
Kavitha Yaddanapudi, Robert A Mitchell, John W Eaton.
Oncoimmunology, 2013 Jun 27; 2(3). PMID: 23802081    Free PMC article.
β-mannosylceramide activates type I natural killer t cells to induce tumor immunity without inducing long-term functional anergy.
Jessica J O'Konek, Shingo Kato, +6 authors, Jay A Berzofsky.
Clin Cancer Res, 2013 Jun 28; 19(16). PMID: 23804426    Free PMC article.
The heart of the matter: protection of the myocardium from T cells.
Andrew H Lichtman.
J Autoimmun, 2013 Jul 03; 45. PMID: 23810579    Free PMC article.
Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial.
Yong Zhao, Zhaoshun Jiang, +16 authors, Heng Li.
BMC Med, 2013 Jul 11; 11. PMID: 23837842    Free PMC article.
Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.
Kendra N Iskander, Marcin F Osuchowski, +4 authors, Daniel G Remick.
Physiol Rev, 2013 Aug 01; 93(3). PMID: 23899564    Free PMC article.
Highly Cited.
Wnt signaling inhibits CTL memory programming.
Zhengguo Xiao, Zhifeng Sun, Kendra Smyth, Lei Li.
Mol Immunol, 2013 Aug 06; 56(4). PMID: 23911398    Free PMC article.
Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection.
Gaëlle Breton, Nicolas Chomont, +8 authors, Rafick-Pierre Sékaly.
J Immunol, 2013 Aug 07; 191(5). PMID: 23918986    Free PMC article.
Ctla-4 expression and polymorphisms in lung tissue of patients with diagnosed non-small-cell lung cancer.
Adam Antczak, Dorota Pastuszak-Lewandoska, +6 authors, Ewa Brzeziańska.
Biomed Res Int, 2013 Aug 13; 2013. PMID: 23936819    Free PMC article.
CD28: direct and critical receptor for superantigen toxins.
Raymond Kaempfer, Gila Arad, +3 authors, Ziv Rotfogel.
Toxins (Basel), 2013 Sep 12; 5(9). PMID: 24022021    Free PMC article.
Role of Th17 cells in skin inflammation of allergic contact dermatitis.
Matthias Peiser.
Clin Dev Immunol, 2013 Sep 12; 2013. PMID: 24023564    Free PMC article.
Upregulation of TIM-3 and PD-1 on CD4+ and CD8+ T Cells Associated with Dysfunction of Cell-Mediated Immunity after Colorectal Cancer Operation.
Yosuke Arai, Hiroaki Saito, Masahide Ikeguchi.
Yonago Acta Med, 2012 Mar 01; 55(1). PMID: 24031134    Free PMC article.
Effect of soluble inducible costimulator level and its polymorphisms on age-related macular degeneration.
Honghua Yu, Xiulan Zou, +4 authors, Yuping Zou.
DNA Cell Biol, 2013 Oct 03; 32(12). PMID: 24083358    Free PMC article.
Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis.
Jason S Ellis, So-Hee Hong, Habib Zaghouani, Helen Braley-Mullen.
J Immunol, 2013 Oct 08; 191(10). PMID: 24098053    Free PMC article.
Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials.
Yohei Mineharu, Maria G Castro, +2 authors, Susumu Miyamoto.
Neurol Med Chir (Tokyo), 2013 Oct 22; 53(11). PMID: 24140772    Free PMC article.
Stem cells and targeted approaches to melanoma cure.
George F Murphy, Brian J Wilson, +2 authors, Markus H Frank.
Mol Aspects Med, 2013 Oct 23; 39. PMID: 24145241    Free PMC article.
Characterization of a soluble B7-H3 (sB7-H3) spliced from the intron and analysis of sB7-H3 in the sera of patients with hepatocellular carcinoma.
Weiwei Chen, Peixin Liu, +7 authors, Henggui Liu.
PLoS One, 2013 Nov 07; 8(10). PMID: 24194851    Free PMC article.
Emerging Co-signaling Networks in T Cell Immune Regulation.
Keunok Jung, Inhak Choi.
Immune Netw, 2013 Nov 08; 13(5). PMID: 24198743    Free PMC article.
Abatacept in B7-1-positive proteinuric kidney disease.
Chih-Chuan Yu, Alessia Fornoni, +18 authors, Peter Mundel.
N Engl J Med, 2013 Nov 12; 369(25). PMID: 24206430    Free PMC article.
Highly Cited.
CD28 and ITK signals regulate autoreactive T cell trafficking.
Nitya Jain, Bing Miu, +8 authors, Joonsoo Kang.
Nat Med, 2013 Nov 26; 19(12). PMID: 24270545    Free PMC article.
Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go.
Angela Vasaturo, Stefania Di Blasio, +4 authors, Stanleyson V Hato.
Front Immunol, 2013 Dec 19; 4. PMID: 24348481    Free PMC article.
From single nucleotide polymorphisms to constant immunosuppression: mesenchymal stem cell therapy for autoimmune diseases.
Raghavan Chinnadurai, Edmund K Waller, Jacques Galipeau, Ajay K Nooka.
Biomed Res Int, 2013 Dec 19; 2013. PMID: 24350294    Free PMC article.
The upregulation of programmed death 1 on peripheral blood T cells of glioma is correlated with disease progression.
Bo Wei, Le Wang, +3 authors, Zhigang Sun.
Tumour Biol, 2014 Jan 01; 35(4). PMID: 24375192
Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis.
Xin Huang, Yaping Chen, +4 authors, Alfred Ayala.
J Immunol, 2014 Jan 01; 192(3). PMID: 24379123    Free PMC article.
Harnessing the immune system for the treatment of breast cancer.
Xinguo Jiang.
J Zhejiang Univ Sci B, 2014 Jan 07; 15(1). PMID: 24390741    Free PMC article.
Costimulatory molecule VSIG4 exclusively expressed on macrophages alleviates renal tubulointerstitial injury in VSIG4 KO mice.
Yan Li, Yi-Qin Wang, +8 authors, Fa-Huan Yuan.
J Nephrol, 2014 Jan 16; 27(1). PMID: 24424721
Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.
Kevin R Mott, Sariah J Allen, +7 authors, Homayon Ghiasi.
PLoS One, 2014 Jan 30; 9(1). PMID: 24475315    Free PMC article.
Implications of genome-wide association studies in novel therapeutics in primary biliary cirrhosis.
Marco Carbone, Ana Lleo, Richard N Sandford, Pietro Invernizzi.
Eur J Immunol, 2014 Feb 01; 44(4). PMID: 24481870    Free PMC article.
Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses.
Shanthi Herath, Adel Benlahrech, +8 authors, Steven Patterson.
PLoS One, 2014 Feb 08; 9(2). PMID: 24505475    Free PMC article.
Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant.
Anna U Bielinska, Paul E Makidon, +7 authors, James R Baker.
J Immunol, 2014 Feb 18; 192(6). PMID: 24532579    Free PMC article.
Tracking and treating activated T cells.
N H Kim, V Nadithe, M Elsayed, O M Merkel.
J Drug Deliv Sci Technol, 2013 Jan 01; 23(1). PMID: 24660025    Free PMC article.
Abatacept in B7-1-positive proteinuric kidney disease.
Anna Greka, Astrid Weins, Peter Mundel.
N Engl J Med, 2014 Mar 29; 370(13). PMID: 24670178    Free PMC article.
Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer.
Keunwook Lee, Hyekyung Hwang, Ki Taek Nam.
Gut Liver, 2014 Mar 29; 8(2). PMID: 24672653    Free PMC article.
Role of podocyte B7-1 in diabetic nephropathy.
Paolo Fiorina, Andrea Vergani, +23 authors, Mohamed H Sayegh.
J Am Soc Nephrol, 2014 Mar 29; 25(7). PMID: 24676639    Free PMC article.
VISTA is an immune checkpoint molecule for human T cells.
J Louise Lines, Eirini Pantazi, +8 authors, Randolph Noelle.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691993    Free PMC article.
Highly Cited.
VISTA Regulates the Development of Protective Antitumor Immunity.
Isabelle Le Mercier, Wenna Chen, +5 authors, Li Wang.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691994    Free PMC article.
Highly Cited.
Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms.
Suryasarathi Dasgupta, Deniz Erturk-Hasdemir, +2 authors, Dennis L Kasper.
Cell Host Microbe, 2014 Apr 12; 15(4). PMID: 24721570    Free PMC article.
Highly Cited.
Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis.
Kang-kang Liu, Qing-tong Wang, +3 authors, Wei Wei.
Acta Pharmacol Sin, 2014 Apr 15; 35(5). PMID: 24727939    Free PMC article.
CD 152 gene polymorphisms and risk of osteosarcoma in Chinese population.
Zhengqi Chang, Ruoxian Song, +2 authors, Xiuchun Yu.
Tumour Biol, 2014 Apr 15; 35(7). PMID: 24729087
Kevin P Nikitczuk, Edmund C Lattime, Rene S Schloss, Martin L Yarmush.
Nano Life, 2010 Sep 01; 1(3-4). PMID: 24772192    Free PMC article.
Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer.
Julie R Brahmer, Drew M Pardoll.
Cancer Immunol Res, 2014 Apr 30; 1(2). PMID: 24777499    Free PMC article.
Highly Cited. Review.
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.
Muhammad Zaeem Noman, Giacomo Desantis, +5 authors, Salem Chouaib.
J Exp Med, 2014 Apr 30; 211(5). PMID: 24778419    Free PMC article.
Highly Cited.
All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.
Sumantha Bhatt, Jie Qin, +4 authors, Lina Lu.
J Immunol, 2014 May 03; 192(11). PMID: 24790153    Free PMC article.
Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene.
Qingqing Jiao, Cuiping Liu, +11 authors, Qihong Qian.
Int J Genomics, 2014 May 27; 2014. PMID: 24860805    Free PMC article.
Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation.
Dagmar Quandt, Simon Jasinski-Bergner, +2 authors, Barbara Seliger.
J Transl Med, 2014 Jun 03; 12. PMID: 24885059    Free PMC article.
Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors.
Sarah Nicholas, Dimitris Mathios, +3 authors, Michael Lim.
Brain Tumor Res Treat, 2013 Apr 01; 1(1). PMID: 24904882    Free PMC article.
Serum B7-H4 expression is a significant prognostic indicator for patients with gastric cancer.
Hongbing Shi, Mei Ji, +8 authors, Jingting Jiang.
World J Surg Oncol, 2014 Jun 21; 12. PMID: 24947047    Free PMC article.
Downregulation of CD40 expression contributes to the accumulation of myeloid-derived suppressor cells in gastric tumors.
Jin Shen, Xiaojuan Chen, +2 authors, Weichang Chen.
Oncol Lett, 2014 Jul 11; 8(2). PMID: 25009656    Free PMC article.
T-cell co-stimulatory blockade in kidney transplantation: back to the bench.
Leonardo V Riella, Mohamed H Sayegh.
Kidney Int Suppl (2011), 2011 Aug 01; 1(2). PMID: 25018899    Free PMC article.
Current status of cancer immunotherapy.
K Kono.
J Stem Cells Regen Med, 2014 Jul 31; 10(1). PMID: 25075156    Free PMC article.
Clinical significance of serum soluble T cell regulatory molecules in clear cell renal cell carcinoma.
Akinori Masuda, Kyoko Arai, +9 authors, Takao Kamai.
Biomed Res Int, 2014 Aug 05; 2014. PMID: 25089268    Free PMC article.
Silencing B7-H1 enhances the anti-tumor effect of bladder cancer antigen-loaded dendritic cell vaccine in vitro.
Shuo Wang, Yonghua Wang, +5 authors, Xinsheng Wang.
Onco Targets Ther, 2014 Aug 15; 7. PMID: 25120371    Free PMC article.
Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vγ2Vδ2 T cells after Mycobacterium tuberculosis infection or vaccination.
Hongbo Shen, Yunqi Wang, +5 authors, Zheng W Chen.
Eur J Immunol, 2014 Aug 22; 45(2). PMID: 25141829    Free PMC article.
Urinary CD80 levels as a diagnostic biomarker of minimal change disease.
Chen Ling, Xiaorong Liu, +4 authors, Qun Meng.
Pediatr Nephrol, 2014 Aug 22; 30(2). PMID: 25142334
Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner.
Emily K Moser, Matthew M Hufford, Thomas J Braciale.
PLoS Pathog, 2014 Aug 22; 10(8). PMID: 25144228    Free PMC article.
Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment.
Kousaku Mimura, Ley-Fang Kua, +8 authors, Koji Kono.
Cancer Sci, 2014 Aug 27; 105(10). PMID: 25154680    Free PMC article.
Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.
Sheetal Bodhankar, Yingxin Chen, +3 authors, Halina Offner.
Front Cell Neurosci, 2014 Aug 27; 8. PMID: 25157219    Free PMC article.
B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody-mediated nephritis.
R D Pawar, B Goilav, +6 authors, C Putterman.
Clin Exp Immunol, 2014 Sep 11; 179(2). PMID: 25205493    Free PMC article.
Imbalance of circulating monocyte subsets and PD-1 dysregulation in Q fever endocarditis: the role of IL-10 in PD-1 modulation.
Mignane B Ka, Françoise Gondois-Rey, +5 authors, Jean-Louis Mege.
PLoS One, 2014 Sep 12; 9(9). PMID: 25211350    Free PMC article.
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Li Wang, Isabelle Le Mercier, +7 authors, Randolph J Noelle.
Proc Natl Acad Sci U S A, 2014 Oct 01; 111(41). PMID: 25267631    Free PMC article.
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
Chun Zeng, Xin Yi, +6 authors, Aimin Zhou.
J Endocrinol, 2014 Oct 08; 223(3). PMID: 25287058    Free PMC article.
Functional phenotype of synovial monocytes modulating inflammatory T-cell responses in rheumatoid arthritis (RA).
Bo Ruem Yoon, Su-Jin Yoo, +5 authors, Won-Woo Lee.
PLoS One, 2014 Oct 21; 9(10). PMID: 25329467    Free PMC article.
PD-1 induction through TCR activation is partially regulated by endogenous TGF-β.
Raja Rekik, Nadia Belhadj Hmida, +3 authors, Melika Ben Ahmed.
Cell Mol Immunol, 2014 Nov 05; 12(5). PMID: 25363526    Free PMC article.
Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.
Peiliang Geng, Xiaoxin Zhao, +9 authors, Houjie Liang.
PLoS One, 2014 Nov 05; 9(11). PMID: 25369324    Free PMC article.
Immunotherapy for Lung Cancer: Has it Finally Arrived?
Ahmed A Mostafa, Don G Morris.
Front Oncol, 2014 Nov 07; 4. PMID: 25374843    Free PMC article.
Immunity and Immunopathology in the Tuberculous Granuloma.
Antonio J Pagán, Lalita Ramakrishnan.
Cold Spring Harb Perspect Med, 2014 Nov 08; 5(9). PMID: 25377142    Free PMC article.
B7-H4 expression is correlated with tumor progression and clinical outcome in urothelial cell carcinoma.
Min Fan, Qianfeng Zhuang, +5 authors, Xianlin Xu.
Int J Clin Exp Pathol, 2014 Nov 18; 7(10). PMID: 25400757    Free PMC article.
Structure and cancer immunotherapy of the B7 family member B7x.
Hyungjun Jeon, Vladimir Vigdorovich, +13 authors, Xingxing Zang.
Cell Rep, 2014 Dec 02; 9(3). PMID: 25437562    Free PMC article.
B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease.
Ruishu Deng, Kaniel Cassady, +6 authors, Defu Zeng.
J Immunol, 2014 Dec 10; 194(2). PMID: 25488990    Free PMC article.
Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein.
Murali Janakiram, Jordan M Chinai, +11 authors, Xingxing Zang.
Clin Cancer Res, 2015 Jan 01; 21(10). PMID: 25549724    Free PMC article.
The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy.
Joanne Leung, Woong-Kyung Suh.
Immune Netw, 2015 Jan 01; 14(6). PMID: 25550693    Free PMC article.
Simulations of site-specific target-mediated pharmacokinetic models for guiding the development of bispecific antibodies.
Vaishali L Chudasama, Anup Zutshi, +3 authors, John M Harrold.
J Pharmacokinet Pharmacodyn, 2015 Jan 07; 42(1). PMID: 25559227
Exploiting synergy: immune-based combinations in the treatment of prostate cancer.
Mauricio Burotto, Nishith Singh, +2 authors, Ravi A Madan.
Front Oncol, 2015 Jan 08; 4. PMID: 25566495    Free PMC article.
The inducible costimulator augments Tc17 cell responses to self and tumor tissue.
Michelle H Nelson, Sreenath Kundimi, +9 authors, Chrystal M Paulos.
J Immunol, 2015 Jan 13; 194(4). PMID: 25576595    Free PMC article.
Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma.
Weiqing Jing, Jill A Gershan, +4 authors, Bryon D Johnson.
J Immunother Cancer, 2015 Jan 24; 3(1). PMID: 25614821    Free PMC article.
A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.
Tie Zheng Hou, Omar S Qureshi, +4 authors, David M Sansom.
J Immunol, 2015 Jan 30; 194(5). PMID: 25632005    Free PMC article.
Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.
R Fujisawa, F Haseda, +8 authors, T Hanafusa.
Clin Exp Immunol, 2015 Feb 17; 180(3). PMID: 25682896    Free PMC article.
Melanoma: Molecular Pathogenesis and Therapeutic Management.
Yuxin Liu, M Saeed Sheikh.
Mol Cell Pharmacol, 2014 Jan 01; 6(3). PMID: 25745537    Free PMC article.
Immunoregulatory molecules in patients with gestational diabetes mellitus.
Karen Priscilla Tezotto Pendeloski, Rosiane Mattar, +3 authors, Silvia Daher.
Endocrine, 2015 Mar 11; 50(1). PMID: 25754913
ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection.
Clare L Marriott, Gianluca Carlesso, Ronald Herbst, David R Withers.
Eur J Immunol, 2015 Mar 11; 45(6). PMID: 25754933    Free PMC article.
Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options.
Vijayakumar Velu, Ravi Dyavar Shetty, Marie Larsson, Esaki M Shankar.
Retrovirology, 2015 Mar 11; 12. PMID: 25756928    Free PMC article.
Highly Cited. Review.
CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice.
M Poggi, S O Morin, +10 authors, J A Nunès.
Int J Obes (Lond), 2015 Mar 17; 39(6). PMID: 25771927
Viral infection of human lung macrophages increases PDL1 expression via IFNβ.
Karl J Staples, Ben Nicholas, +7 authors, Tom M A Wilkinson.
PLoS One, 2015 Mar 17; 10(3). PMID: 25775126    Free PMC article.
The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus.
Shuangyan Luo, Yu Liu, +9 authors, Qianjin Lu.
Clin Epigenetics, 2015 Mar 20; 7. PMID: 25789080    Free PMC article.
PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation.
Li Liu, Qiangsun Zheng, +3 authors, Zhiquan Wang.
J Cell Mol Med, 2015 Mar 27; 19(6). PMID: 25810125    Free PMC article.
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma.
Kathleen M Mahoney, Gordon J Freeman, David F McDermott.
Clin Ther, 2015 Apr 01; 37(4). PMID: 25823918    Free PMC article.
Highly Cited. Review.
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.
Padmanee Sharma, James P Allison.
Cell, 2015 Apr 11; 161(2). PMID: 25860605    Free PMC article.
Highly Cited. Review.
Checkpoint modulation--A new way to direct the immune system against renal cell carcinoma.
Jens Bedke, Stephan Kruck, +2 authors, Peter J Goebell.
Hum Vaccin Immunother, 2015 Apr 29; 11(5). PMID: 25912622    Free PMC article.
Lymphoma: immune evasion strategies.
Ranjan Upadhyay, Linda Hammerich, +3 authors, Joshua D Brody.
Cancers (Basel), 2015 May 06; 7(2). PMID: 25941795    Free PMC article.
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Therese Liechtenstein, Noemi Perez-Janices, +8 authors, David Escors.
Oncoimmunology, 2014 Jan 01; 3(7). PMID: 25954597    Free PMC article.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Developing therapeutic 'arrows' with the precision of William Tell: the time has come for targeted therapies in kidney disease.
Peter Mundel, Anna Greka.
Curr Opin Nephrol Hypertens, 2015 Jun 08; 24(4). PMID: 26050127    Free PMC article.
Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells.
Svetlana Karakhanova, Julia Link, +11 authors, Alexandr V Bazhin.
Oncoimmunology, 2015 Jul 03; 4(4). PMID: 26137414    Free PMC article.
Costimulatory blockade: A novel approach to the treatment of glomerular disease?
Pasquale Esposito, Teresa Rampino, Antonio Dal Canton.
World J Methodol, 2015 Jul 04; 5(2). PMID: 26140268    Free PMC article.
Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme.
Liu Yang, Geng Guo, Xiao-yuan Niu, Jing Liu.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26167495    Free PMC article.
Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints.
Niki Karachaliou, Maria Gonzalez Cao, +4 authors, Rafael Rosell.
Cancer Biol Med, 2015 Jul 16; 12(2). PMID: 26175923    Free PMC article.
Clinical Management of Multiple Melanoma Brain Metastases: A Systematic Review.
Sharad Goyal, Ann W Silk, +4 authors, Howard L Kaufman.
JAMA Oncol, 2015 Jul 17; 1(5). PMID: 26181286    Free PMC article.
Systematic Review.
Upregulation of Immune Checkpoint Molecules, PD-1 and LAG-3, on CD4+ and CD8+ T Cells after Gastric Cancer Surgery.
Seigo Takaya, Hiroaki Saito, Masahide Ikeguchi.
Yonago Acta Med, 2015 Jul 21; 58(1). PMID: 26190896    Free PMC article.
Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.
Yuko Ohta, Martin F Flajnik.
Immunol Rev, 2015 Aug 19; 267(1). PMID: 26284468    Free PMC article.
B7-1 Is Not Induced in Podocytes of Human and Experimental Diabetic Nephropathy.
Elena Gagliardini, Rubina Novelli, +4 authors, Giuseppe Remuzzi.
J Am Soc Nephrol, 2015 Sep 01; 27(4). PMID: 26319246    Free PMC article.
Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response.
Julia Merkenschlager, George Kassiotis.
Front Immunol, 2015 Sep 01; 6. PMID: 26322045    Free PMC article.
An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression.
A E Rice, Y E Latchman, +3 authors, F R Jones.
Cancer Gene Ther, 2015 Sep 05; 22(9). PMID: 26337747
Tumor associated PD-L1 expression pattern in microscopically tumor positive sentinel lymph nodes in patients with melanoma.
Ahmad A Tarhini, Haris Zahoor, +6 authors, John M Kirkwood.
J Transl Med, 2015 Oct 01; 13. PMID: 26419843    Free PMC article.
Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand.
Hong-Sheng Lim, Shaun-Paul Cordoba, +4 authors, P Anton van der Merwe.
J Immunol, 2015 Oct 27; 195(11). PMID: 26500347    Free PMC article.
Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential.
Charlotte Spitz, Holger Winkels, +4 authors, Norbert Gerdes.
Cell Mol Life Sci, 2015 Nov 01; 73(5). PMID: 26518635
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition.
Elizabeth I Buchbinder, Anupam Desai.
Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876    Free PMC article.
Highly Cited. Review.
FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression.
Anil K Chauhan, Terry L Moore, Ye Bi, Chen Chen.
J Biol Chem, 2015 Nov 20; 291(3). PMID: 26582197    Free PMC article.
[Clinical Research Progress of Anti PD-1/PD-L1 Monoclonal Antibody in the Treatment of Lung Cancer].
Zhiyu Huang, Hui Li, Yun Fan.
Zhongguo Fei Ai Za Zhi, 2015 Nov 20; 18(11). PMID: 26582228    Free PMC article.
Immune Checkpoint Modulation in Colorectal Cancer: What's New and What to Expect.
Julie Jacobs, Evelien Smits, +2 authors, Vanessa Deschoolmeester.
J Immunol Res, 2015 Nov 26; 2015. PMID: 26605342    Free PMC article.
Expression levels of B7-H3 and TLT-2 in human oral squamous cell carcinoma.
Shan-Shan Zhang, Jing Tang, +5 authors, Hong-Yu Yang.
Oncol Lett, 2015 Dec 02; 10(2). PMID: 26622626    Free PMC article.
Differential expression of 2IgB7-H3 and 4IgB7-H3 in cancer cell lines and glioma tissues.
Zhenxin Wang, Jianfeng Yang, +3 authors, Yinghui Zhou.
Oncol Lett, 2015 Dec 02; 10(4). PMID: 26622819    Free PMC article.
Lung cancer biomarkers, targeted therapies and clinical assays.
Jai N Patel, Jennifer L Ersek, Edward S Kim.
Transl Lung Cancer Res, 2015 Dec 03; 4(5). PMID: 26629419    Free PMC article.
Genome-Wide Association Studies in Primary Biliary Cirrhosis.
Aliya F Gulamhusein, Brian D Juran, Konstantinos N Lazaridis.
Semin Liver Dis, 2015 Dec 18; 35(4). PMID: 26676814    Free PMC article.
Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis.
Bo Ruem Yoon, Yeon-Ho Chung, +6 authors, Won-Woo Lee.
J Biol Chem, 2015 Dec 25; 291(8). PMID: 26702052    Free PMC article.
Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors.
Daniel T Harris, David M Kranz.
Trends Pharmacol Sci, 2015 Dec 26; 37(3). PMID: 26705086    Free PMC article.
Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia.
Weiwei Shen, Mrinal M Patnaik, +2 authors, Kah-Whye Peng.
Blood, 2015 Dec 30; 127(11). PMID: 26712908    Free PMC article.
Programmed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor-beta role.
Mariacarmela Santarpia, María González-Cao, +3 authors, Rafael Rosell.
Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798582    Free PMC article.
An increased number of PD-1+ and Tim-3+ CD8+ T cells is involved in immune evasion in gastric cancer.
Shuichi Takano, Hiroaki Saito, Masahide Ikeguchi.
Surg Today, 2016 Jan 24; 46(11). PMID: 26801344
Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic.
Kinga Majchrzak, Michelle H Nelson, +5 authors, Chrystal M Paulos.
Cancer Immunol Immunother, 2016 Jan 31; 65(3). PMID: 26825102    Free PMC article.
How Cancers Escape Immune Destruction and Mechanisms of Action for the New Significantly Active Immune Therapies: Helping Nonimmunologists Decipher Recent Advances.
Jonathan L Messerschmidt, George C Prendergast, Gerald L Messerschmidt.
Oncologist, 2016 Feb 03; 21(2). PMID: 26834161    Free PMC article.
Basics of PD-1 in self-tolerance, infection, and cancer immunity.
Shunsuke Chikuma.
Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303
Immunotherapy for Gastric Cancer: A Focus on Immune Checkpoints.
Maria Alsina, Markus Moehler, +2 authors, Josep Tabernero.
Target Oncol, 2016 Feb 18; 11(4). PMID: 26880697
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium.
Eileen S Kim, Jennifer E Kim, +3 authors, Michael Lim.
J Immunol Res, 2016 Feb 18; 2016. PMID: 26881264    Free PMC article.
Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma.
Michihito Tagawa, Naoya Maekawa, Satoru Konnai, Satoshi Takagi.
PLoS One, 2016 Feb 24; 11(2). PMID: 26901565    Free PMC article.
The prevalence and clinicopathological features of programmed death-ligand 1 (PD-L1) expression: a pooled analysis of literatures.
Ziying Lin, Yutong Xu, +4 authors, Wenhua Liang.
Oncotarget, 2016 Mar 02; 7(12). PMID: 26930715    Free PMC article.
Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections.
Maria Lina Tornesello, Luigi Buonaguro, Francesco Izzo, Franco M Buonaguro.
Oncotarget, 2016 Mar 05; 7(18). PMID: 26943571    Free PMC article.
Signaling in T cells - is anything the m(a)TOR with the picture(s)?
Mark Boothby.
F1000Res, 2016 Mar 08; 5. PMID: 26949528    Free PMC article.
B7-H3 and B7-H4 are independent predictors of a poor prognosis in patients with pancreatic cancer.
Hong Xu, Xiaoling Chen, +6 authors, Yixiang Mao.
Oncol Lett, 2016 Mar 22; 11(3). PMID: 26998087    Free PMC article.
Effect of tumor necrosis factor-α induced protein 8 like-2 on immune function of dendritic cells in mice following acute insults.
Ying-Yi Luan, Ren-Qi Yao, +3 authors, Yong-Ming Yao.
Oncotarget, 2016 Mar 31; 7(21). PMID: 27029075    Free PMC article.
Successful Treatment of Focal Segmental Glomerulosclerosis after Kidney Transplantation with Plasma Exchange and Abatacept in a Patient with Juvenile Rheumatoid Arthritis.
Hannelore Sprenger-Mähr, Emanuel Zitt, Afschin Soleiman, Karl Lhotta.
Case Rep Transplant, 2016 Apr 19; 2016. PMID: 27088031    Free PMC article.
Nivolumab, anti-programmed death-1 (PD-1) monoclonal antibody immunotherapy: Role in advanced cancers.
Arun Rajan, Chul Kim, +2 authors, James L Gulley.
Hum Vaccin Immunother, 2016 May 03; 12(9). PMID: 27135835    Free PMC article.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination.
Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert.
Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885
Highly Cited. Review.
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease.
John Attanasio, E John Wherry.
Immunity, 2016 May 19; 44(5). PMID: 27192569    Free PMC article.
Highly Cited. Review.
Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules.
Sreenivas Gannavaram, Parna Bhattacharya, +3 authors, Hira L Nakhasi.
Front Immunol, 2016 Jun 01; 7. PMID: 27242794    Free PMC article.
What does the future hold for immunotherapy in cancer?
Jarushka Naidoo, Bob T Li, Katja Schindler, David B Page.
Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275490    Free PMC article.
Menopausal status influences the expression of programmed death (PD)-1 and its ligand PD-L1 on immune cells from the human female reproductive tract.
Zheng Shen, Marta Rodriguez-Garcia, +2 authors, Charles R Wira.
Am J Reprod Immunol, 2016 Jun 21; 76(2). PMID: 27321759    Free PMC article.
The Immunogenicity of Colorectal Cancer in Relation to Tumor Development and Treatment.
Natasja L de Vries, Marloes Swets, +2 authors, Peter J K Kuppen.
Int J Mol Sci, 2016 Jul 02; 17(7). PMID: 27367680    Free PMC article.
The current status of checkpoint inhibitors in metastatic bladder cancer.
Omar Fahmy, Mohd Ghani Khairul-Asri, Arnulf Stenzl, Georgios Gakis.
Clin Exp Metastasis, 2016 Jul 07; 33(7). PMID: 27380916
Systematic Review.
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.
Rémi Fromentin, Wendy Bakeman, +13 authors, Nicolas Chomont.
PLoS Pathog, 2016 Jul 16; 12(7). PMID: 27415008    Free PMC article.
Highly Cited.
Group 2 Innate Lymphoid Cells Promote an Early Antibody Response to a Respiratory Antigen in Mice.
Li Yin Drake, Koji Iijima, Kathleen Bartemes, Hirohito Kita.
J Immunol, 2016 Jul 17; 197(4). PMID: 27421480    Free PMC article.
Magneto-nanosensor platform for probing low-affinity protein-protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction.
Jung-Rok Lee, Daniel J B Bechstein, +5 authors, Shan X Wang.
Nat Commun, 2016 Jul 23; 7. PMID: 27447090    Free PMC article.
Immune-Modulation by Epidermal Growth Factor Receptor Inhibitors: Implication on Anti-Tumor Immunity in Lung Cancer.
Jin S Im, Amanda C Herrmann, +4 authors, Roman Perez-Soler.
PLoS One, 2016 Jul 29; 11(7). PMID: 27467256    Free PMC article.
Therapeutic targets and new directions for antibodies developed for ovarian cancer.
Heather J Bax, Debra H Josephs, +3 authors, Sophia N Karagiannis.
MAbs, 2016 Oct 30; 8(8). PMID: 27494775    Free PMC article.
B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration.
Yan Li, Jie Huang, +6 authors, Jian Wang.
Sci Rep, 2016 Aug 16; 6. PMID: 27515382    Free PMC article.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Benjamin Herzberg, Meghan J Campo, Justin F Gainor.
Oncologist, 2016 Aug 19; 22(1). PMID: 27534574    Free PMC article.
HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status.
Haiying Cheng, Murali Janakiram, +7 authors, Xingxing Zang.
Clin Cancer Res, 2016 Aug 25; 23(3). PMID: 27553831    Free PMC article.
Immune checkpoint inhibitors: the new frontier in non-small-cell lung cancer treatment.
Hazem El-Osta, Kamran Shahid, Glenn M Mills, Prakash Peddi.
Onco Targets Ther, 2016 Aug 31; 9. PMID: 27574451    Free PMC article.
Ipilimumab reshapes T cell memory subsets in melanoma patients with clinical response.
Joana Felix, Jérome Lambert, +13 authors, Hélène Moins-Teisserenc.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622012    Free PMC article.
Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer.
Zhenyu Xu, Jing Shen, +12 authors, Zhangang Xiao.
Oncoimmunology, 2016 Sep 14; 5(8). PMID: 27622076    Free PMC article.
TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axis.
Xinru Zhou, Yong Mao, +12 authors, Xueguang Zhang.
Oncotarget, 2016 Sep 15; 7(41). PMID: 27626488    Free PMC article.
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma.
Asma Beldi-Ferchiou, Marion Lambert, +10 authors, Sophie Caillat-Zucman.
Oncotarget, 2016 Sep 24; 7(45). PMID: 27662664    Free PMC article.
Highly Cited.
Programmed death-1+ T cells inhibit effector T cells at the pathological site of miliary tuberculosis.
A Singh, A Mohan, A B Dey, D K Mitra.
Clin Exp Immunol, 2016 Sep 27; 187(2). PMID: 27665733    Free PMC article.
Antigen-Specific Immune Modulation Targets mTORC1 Function To Drive Chemokine Receptor-Mediated T Cell Tolerance.
Weirong Chen, Xiaoxiao Wan, +4 authors, Habib Zaghouani.
J Immunol, 2016 Sep 28; 197(9). PMID: 27671108    Free PMC article.
B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.
Luisa Klotz, Ivan Kuzmanov, +13 authors, Heinz Wiendl.
Proc Natl Acad Sci U S A, 2016 Sep 28; 113(41). PMID: 27671636    Free PMC article.
Trends and advances in tumor immunology and lung cancer immunotherapy.
Mohanad Aldarouish, Cailian Wang.
J Exp Clin Cancer Res, 2016 Oct 01; 35(1). PMID: 27686848    Free PMC article.
Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction.
Revital Levy, Ziv Rotfogel, +5 authors, Raymond Kaempfer.
Proc Natl Acad Sci U S A, 2016 Oct 30; 113(42). PMID: 27708164    Free PMC article.
Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.
Rita Diehl, Fabienne Ferrara, +4 authors, Johannes Boltze.
Cell Mol Immunol, 2016 Oct 11; 14(2). PMID: 27721455    Free PMC article.
Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy.
Ju Yeon Lee, Hyun Tae Lee, +11 authors, Yong-Seok Heo.
Nat Commun, 2016 Nov 01; 7. PMID: 27796306    Free PMC article.
Highly Cited.
Recent advances in understanding antitumor immunity.
Rodrigo Ramella Munhoz, Michael Andrew Postow.
F1000Res, 2016 Nov 03; 5. PMID: 27803807    Free PMC article.
Posttranscriptional Control of PD-L1 Expression by 17β-Estradiol via PI3K/Akt Signaling Pathway in ERα-Positive Cancer Cell Lines.
Lingyun Yang, Feng Huang, +5 authors, Zongbing You.
Int J Gynecol Cancer, 2016 Nov 22; 27(2). PMID: 27870715    Free PMC article.
Immune checkpoint therapy for pancreatic cancer.
Henrik Johansson, Roland Andersson, +3 authors, Daniel Ansari.
World J Gastroenterol, 2016 Dec 07; 22(43). PMID: 27920468    Free PMC article.
VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.
Valentina Comunanza, Davide Corà, +9 authors, Federico Bussolino.
EMBO Mol Med, 2016 Dec 16; 9(2). PMID: 27974353    Free PMC article.
Spontaneous germinal centers and autoimmunity.
Phillip P Domeier, Stephanie L Schell, Ziaur S M Rahman.
Autoimmunity, 2017 Feb 09; 50(1). PMID: 28166685    Free PMC article.
Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease.
Wei Lin, Panpan Zhang, +7 authors, Peter E Lipsky.
Arthritis Res Ther, 2017 Feb 12; 19(1). PMID: 28183334    Free PMC article.
CIITA-driven MHC class II expressing tumor cells can efficiently prime naive CD4+ TH cells in vivo and vaccinate the host against parental MHC-II-negative tumor cells.
Farah Bou Nasser Eddine, Greta Forlani, +3 authors, Roberto S Accolla.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197387    Free PMC article.
The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis.
Pingping Hu, Qiqi Liu, +4 authors, Jiandong Zhang.
Sci Rep, 2017 Feb 18; 7. PMID: 28211499    Free PMC article.
Systematic Review.
Immunoregulatory functions of VISTA.
Elizabeth C Nowak, J Louise Lines, +7 authors, Randolph J Noelle.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258694    Free PMC article.
Highly Cited. Review.
Potential targeting of B7-H4 for the treatment of cancer.
Joseph R Podojil, Stephen D Miller.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258701    Free PMC article.
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale.
Science, 2017 Mar 11; 355(6332). PMID: 28280247    Free PMC article.
Highly Cited.
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.
Alice O Kamphorst, Andreas Wieland, +17 authors, Rafi Ahmed.
Science, 2017 Mar 11; 355(6332). PMID: 28280249    Free PMC article.
Highly Cited.
Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
Fei Zhang, Hudie Wei, +8 authors, Aiwu Zhou.
Cell Discov, 2017 Mar 11; 3. PMID: 28280600    Free PMC article.
Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint.
Raymond Kaempfer, Andrey Popugailo, +3 authors, Ziv Rotfogel.
Receptors Clin Investig, 2017 Mar 14; 4(1). PMID: 28286804    Free PMC article.
Impairment of systemic DHA synthesis affects macrophage plasticity and polarization: implications for DHA supplementation during inflammation.
Emanuela Talamonti, Anna M Pauter, +3 authors, Anders Jacobsson.
Cell Mol Life Sci, 2017 Mar 17; 74(15). PMID: 28299384    Free PMC article.
Immune checkpoint dysfunction in large and medium vessel vasculitis.
Ryu Watanabe, Hui Zhang, +2 authors, Cornelia M Weyand.
Am J Physiol Heart Circ Physiol, 2017 Mar 21; 312(5). PMID: 28314758    Free PMC article.
Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis.
A C Foks, J Kuiper.
Br J Pharmacol, 2017 Apr 04; 174(22). PMID: 28369782    Free PMC article.
Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis.
Qiang Liu, Chun-Sheng Li.
Chin Med J (Engl), 2017 Apr 12; 130(8). PMID: 28397730    Free PMC article.
HCV viraemia associates with NK cell activation and dysfunction in antiretroviral therapy-treated HIV/HCV-co-infected subjects.
E Papasavvas, L Azzoni, +9 authors, L J Montaner.
J Viral Hepat, 2017 Apr 19; 24(10). PMID: 28419653    Free PMC article.
Divergent Function of Programmed Death-Ligand 1 in Donor Tissue versus Recipient Immune System in a Murine Model of Bronchiolitis Obliterans.
Katharina Schütte-Nütgen, Olaf Boenisch, +6 authors, Meera Subramaniam.
Am J Pathol, 2017 Apr 22; 187(6). PMID: 28427861    Free PMC article.
Pulmonary Delivery of Virosome-Bound Antigen Enhances Antigen-Specific CD4+ T Cell Proliferation Compared to Liposome-Bound or Soluble Antigen.
Rebecca A M Blom, Mario Amacker, +4 authors, Christophe von Garnier.
Front Immunol, 2017 Apr 26; 8. PMID: 28439267    Free PMC article.
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Na Li, Wenwen Xu, +11 authors, Li Wang.
Sci Rep, 2017 May 05; 7(1). PMID: 28469254    Free PMC article.
Current state of immunotherapy for non-small cell lung cancer.
Jyoti Malhotra, Salma K Jabbour, Joseph Aisner.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529902    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Inhibitor Therapy: What Line of Therapy and How to Choose?
Chethan Ramamurthy, James L Godwin, Hossein Borghaei.
Curr Treat Options Oncol, 2017 May 24; 18(6). PMID: 28534248
Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.
Gretchen N de Graav, Dennis A Hesselink, +7 authors, Carla C Baan.
Front Immunol, 2017 Jun 18; 8. PMID: 28620390    Free PMC article.
Signals that drive T follicular helper cell formation.
Louise M C Webb, Michelle A Linterman.
Immunology, 2017 Jun 20; 152(2). PMID: 28628194    Free PMC article.
An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells.
Wei Wang, Khawar Ali Shahzad, +5 authors, Chuanlai Shen.
Front Immunol, 2017 Jun 27; 8. PMID: 28649247    Free PMC article.
Variant SNPs at the microRNA complementary site in the B7‑H1 3'‑untranslated region increase the risk of non‑small cell lung cancer.
Wenwen Du, Jianjie Zhu, +6 authors, Jian-An Huang.
Mol Med Rep, 2017 Jul 06; 16(3). PMID: 28677815    Free PMC article.
Negative modulation of suppressive HIV-specific regulatory T cells by IL-2 adjuvanted therapeutic vaccine.
Vedran Brezar, Lylia Hani, +5 authors, Nabila Seddiki.
PLoS Pathog, 2017 Jul 15; 13(7). PMID: 28708863    Free PMC article.
Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab.
Hyun Tae Lee, Ju Yeon Lee, +6 authors, Yong-Seok Heo.
Sci Rep, 2017 Jul 19; 7(1). PMID: 28717238    Free PMC article.
Comparative study of dendritic cells matured by using IL-1β, IL-6, TNF-α and prostaglandins E2 for different time span.
Xuejie Wu, Feng Xu, Jinliang Liu, Guiqiang Wang.
Exp Ther Med, 2017 Aug 16; 14(2). PMID: 28810601    Free PMC article.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656    Free PMC article.
PD-L1 is an activation-independent marker of brown adipocytes.
Jessica R Ingram, Michael Dougan, +12 authors, Hidde L Ploegh.
Nat Commun, 2017 Sep 25; 8(1). PMID: 28935898    Free PMC article.
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
Kaposi's Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes.
Kurtis M Host, Sarah R Jacobs, +5 authors, Blossom Damania.
mBio, 2017 Oct 12; 8(5). PMID: 29018115    Free PMC article.
Efficacy and Safety of Pembrolizumab in Patients Enrolled in KEYNOTE-030 in the United States: An Expanded Access Program.
Tara C Gangadhar, Wen-Jen Hwu, +14 authors, April K S Salama.
J Immunother, 2017 Oct 14; 40(9). PMID: 29028788    Free PMC article.
PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer.
Kousaku Mimura, Jun Liang Teh, +14 authors, Koji Kono.
Cancer Sci, 2017 Oct 17; 109(1). PMID: 29034543    Free PMC article.
Highly Cited.
T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.
Rachel E O'Neill, Wei Du, +6 authors, Xuefang Cao.
J Immunol, 2017 Oct 20; 199(10). PMID: 29046346    Free PMC article.
BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma.
Fen Liu, Chen Chen Jiang, +11 authors, Xu Dong Zhang.
Oncotarget, 2017 Oct 21; 8(41). PMID: 29050218    Free PMC article.
Identification of 14-dehydroergosterol as a novel anti-inflammatory compound inducing tolerogenic dendritic cells.
Yasuhisa Ano, Kumiko Ikado, +2 authors, Daisuke Fujiwara.
Sci Rep, 2017 Oct 27; 7(1). PMID: 29066789    Free PMC article.
High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients.
NiJiati AiErken, Hui-Juan Shi, +5 authors, Ying Lin.
Int J Biol Sci, 2017 Nov 07; 13(9). PMID: 29104508    Free PMC article.
Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy.
Miren Zuazo, Maria Gato-Cañas, +4 authors, David Escors.
Ann Transl Med, 2017 Nov 09; 5(19). PMID: 29114543    Free PMC article.
Combining DNA damaging therapeutics with immunotherapy: more haste, less speed.
Jessica S Brown, Raghav Sundar, Juanita Lopez.
Br J Cancer, 2017 Nov 11; 118(3). PMID: 29123260    Free PMC article.
Highly Cited. Review.
Biodegradable Chitosan Decreases the Immune Response to Trichinella spiralis in Mice.
Klaudia Brodaczewska, Natalia Wolaniuk, +2 authors, Maria Doligalska.
Molecules, 2017 Nov 22; 22(11). PMID: 29156562    Free PMC article.
Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab.
Fei Zhang, Xiaoqiang Qi, +9 authors, Ying Zheng.
Oncotarget, 2017 Nov 23; 8(52). PMID: 29163822    Free PMC article.
Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report.
Helen M McGuire, Elena Shklovskaya, +8 authors, Peter Hersey.
Cancer Immunol Immunother, 2018 Jan 01; 67(4). PMID: 29289977    Free PMC article.
Mycoplasma bovis-Induced Inhibition of Bovine Peripheral Blood Mononuclear Cell Proliferation Is Ameliorated after Blocking the Immune-Inhibitory Programmed Death 1 Receptor.
Muhammad Suleman, Farhan S Cyprian, +4 authors, Jose Perez-Casal.
Infect Immun, 2018 Jan 10; 86(3). PMID: 29311234    Free PMC article.
Role of B and T Lymphocyte Attenuator in Renal Transplant Recipients with Biopsy-Proven Acute Rejection.
Zijie Wang, Haiwei Yang, +7 authors, Min Gu.
Med Sci Monit, 2018 Jan 21; 24. PMID: 29352109    Free PMC article.
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations.
Jun Gong, Alexander Chehrazi-Raffle, Srikanth Reddi, Ravi Salgia.
J Immunother Cancer, 2018 Jan 24; 6(1). PMID: 29357948    Free PMC article.
Highly Cited. Review.
Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1-Negative Human Lung Cancers.
Haiying Cheng, Alain Borczuk, +6 authors, Xingxing Zang.
Clin Cancer Res, 2018 Jan 28; 24(8). PMID: 29374053    Free PMC article.
Expected Paradigm Shift in Brain Metastases Therapy-Immune Checkpoint Inhibitors.
Vishal Jindal, Sorab Gupta.
Mol Neurobiol, 2018 Feb 01; 55(8). PMID: 29383686
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis.
Eleanor A Fallon, Bethany M Biron-Girard, +4 authors, Alfred Ayala.
J Leukoc Biol, 2018 Feb 03;. PMID: 29393983    Free PMC article.
Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response.
J Zhang, C Burn, +7 authors, M Hibma.
Sci Rep, 2018 Feb 07; 8(1). PMID: 29402982    Free PMC article.
Salmonella enterica Serovar Typhimurium Increases Functional PD-L1 Synergistically with Gamma Interferon in Intestinal Epithelial Cells via Salmonella Pathogenicity Island 2.
J M Sahler, C R Eade, C Altier, J C March.
Infect Immun, 2018 Feb 15; 86(5). PMID: 29440366    Free PMC article.
Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design.
Sitanshu S Singh, Seetharama D Jois.
Adv Protein Chem Struct Biol, 2018 Feb 21; 111. PMID: 29459028    Free PMC article.
Microsatellite instability is a biomarker for immune checkpoint inhibitors in endometrial cancer.
Hitomi Yamashita, Kentaro Nakayama, +10 authors, Satoru Kyo.
Oncotarget, 2018 Feb 22; 9(5). PMID: 29464025    Free PMC article.
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.
Yanxia Guo, Alice M Walsh, +18 authors, Sunil Nagpal.
PLoS One, 2018 Mar 01; 13(2). PMID: 29489833    Free PMC article.
Highly Cited.
Immune Monitoring of Cancer Patients Prior to and During CTLA-4 or PD-1/PD-L1 Inhibitor Treatment.
Antje Tunger, Maximilian Kießler, +4 authors, Marc Schmitz.
Biomedicines, 2018 Mar 02; 6(1). PMID: 29494517    Free PMC article.
Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Jessica R Ingram, Olga S Blomberg, +15 authors, Michael Dougan.
Proc Natl Acad Sci U S A, 2018 Mar 28; 115(15). PMID: 29581255    Free PMC article.
Highly Cited.
Artificial Antigen Presenting Cells: An Off the Shelf Approach for Generation of Desirable T-Cell Populations for Broad Application of Adoptive Immunotherapy.
A N Hasan, A Selvakumar, R J O'Reilly.
Adv Genet Eng, 2015 Jan 01; 4(3). PMID: 29644163    Free PMC article.
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses.
Jang Hwan Cho, James J Collins, Wilson W Wong.
Cell, 2018 May 01; 173(6). PMID: 29706540    Free PMC article.
Highly Cited.
Current status of cancer immunotherapy for esophageal squamous cell carcinoma.
Koji Kono, Kousaku Mimura, +9 authors, Shinji Ohki.
Esophagus, 2018 Jun 13; 15(1). PMID: 29892809
B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex.
Joseph R Podojil, Ming-Yi Chiang, +10 authors, Stephen D Miller.
J Immunol, 2018 Jun 15; 201(3). PMID: 29898965    Free PMC article.
Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells.
Mengmeng Zhang, Yongxia Wu, +9 authors, Xue-Zhong Yu.
Front Immunol, 2018 Jul 11; 9. PMID: 29988391    Free PMC article.
Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond.
Emily M Lin, Jun Gong, Samuel J Klempner, Joseph Chao.
World J Gastroenterol, 2018 Jul 12; 24(25). PMID: 29991874    Free PMC article.
B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer.
Ling Wang, Chao Yang, +2 authors, Fu-Biao Kang.
Cancer Cell Int, 2018 Jul 17; 18. PMID: 30008617    Free PMC article.
Evaluation of costimulatory molecules in dogs with B cell high grade lymphoma.
Michihito Tagawa, Chihiro Kurashima, +7 authors, Kazuro Miyahara.
PLoS One, 2018 Jul 25; 13(7). PMID: 30040869    Free PMC article.
Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic.
S P Kang, K Gergich, +4 authors, E H Rubin.
Ann Oncol, 2018 Jul 28; 28(6). PMID: 30052728    Free PMC article.
CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study.
Bing Zhao, Hui Han, +4 authors, Rong Wang.
PeerJ, 2018 Aug 08; 6. PMID: 30083478    Free PMC article.
Immune Checkpoint-Mediated Interactions Between Cancer and Immune Cells in Prostate Adenocarcinoma and Melanoma.
Angela Rita Elia, Sara Caputo, Matteo Bellone.
Front Immunol, 2018 Aug 16; 9. PMID: 30108594    Free PMC article.
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors.
Yang Liu, Yinping Dong, +3 authors, Jinming Yu.
J Hematol Oncol, 2018 Aug 18; 11(1). PMID: 30115069    Free PMC article.
Highly Cited. Review.
Neuroimmune semaphorins as costimulatory molecules and beyond.
Svetlana P Chapoval.
Mol Med, 2018 Aug 24; 24(1). PMID: 30134791    Free PMC article.
Influence of T Cell Coinhibitory Molecules on CD8+ Recall Responses.
Anna B Morris, Layne E Adams, Mandy L Ford.
Front Immunol, 2018 Aug 24; 9. PMID: 30135685    Free PMC article.
Targeting immune checkpoints in melanoma: an update.
Rodrigo R Munhoz, Alejandro Falcón González, Vanessa A Reed, Michael A Postow.
Melanoma Manag, 2015 Nov 01; 2(4). PMID: 30190862    Free PMC article.
Decreased blood CD4+PD-1+ and CD8+PD-1+ T cells in psoriatic patients with and without arthritis.
Joanna Bartosińska, Ewelina Zakrzewska, +5 authors, Krzysztof Giannopoulos.
Postepy Dermatol Alergol, 2018 Sep 13; 35(4). PMID: 30206445    Free PMC article.
Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma.
Aniruddha Chatterjee, Euan J Rodger, +8 authors, Peter Hersey.
iScience, 2018 Sep 22; 4. PMID: 30240750    Free PMC article.
The intracellular signalosome of PD-L1 in cancer cells.
David Escors, María Gato-Cañas, +4 authors, Grazyna Kochan.
Signal Transduct Target Ther, 2018 Oct 03; 3. PMID: 30275987    Free PMC article.
Highly Cited. Review.
PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?
Ramón Cantero-Cid, José Casas-Martin, +11 authors, Eduardo López-Collazo.
BMC Cancer, 2018 Oct 05; 18(1). PMID: 30285662    Free PMC article.
Prognostic role of pretreatment circulating MDSCs in patients with solid malignancies: A meta-analysis of 40 studies.
Peng-Fei Wang, Si-Ying Song, +4 authors, Chang-Xiang Yan.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288362    Free PMC article.
Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts.
Jonathan E Wosen, Dhriti Mukhopadhyay, Claudia Macaubas, Elizabeth D Mellins.
Front Immunol, 2018 Oct 16; 9. PMID: 30319613    Free PMC article.
Highly Cited. Review.
On the Road to Immunotherapy-Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor Antibodies.
Frank J Ward, Lekh N Dahal, Rasha Abu-Eid.
Front Immunol, 2018 Oct 16; 9. PMID: 30319637    Free PMC article.
Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling.
Alexandr V Bazhin, Katharina von Ahn, +2 authors, Svetlana Karakhanova.
Front Immunol, 2018 Oct 26; 9. PMID: 30356906    Free PMC article.
Bacterial Superantigen Toxins, CD28, and Drug Development.
Raymond Kaempfer.
Toxins (Basel), 2018 Nov 09; 10(11). PMID: 30404186    Free PMC article.
Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: From Mechanistic Insights to Biomarkers.
Kelen Cristina Ribeiro Malmegrim, João Rodrigues Lima-Júnior, +3 authors, Maria Carolina Oliveira.
Front Immunol, 2018 Dec 07; 9. PMID: 30505303    Free PMC article.
Efficacy and safety of pembrolizumab as first-line therapy in advanced non-small cell lung cancer with at least 50% PD-L1 positivity: a multicenter retrospective cohort study (HOPE-001).
Motohiro Tamiya, Akihiro Tamiya, +16 authors, Daichi Fujimoto.
Invest New Drugs, 2019 Aug 09; 37(6). PMID: 31392549
Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke.
Hilary A Seifert, Wenbin Zhu, +2 authors, Halina Offner.
Metab Brain Dis, 2019 Aug 15; 34(6). PMID: 31410774    Free PMC article.
The Changing Therapeutic Landscape of Metastatic Renal Cancer.
Javier C Angulo, Oleg Shapiro.
Cancers (Basel), 2019 Aug 25; 11(9). PMID: 31443471    Free PMC article.
Radiation as an In Situ Auto-Vaccination: Current Perspectives and Challenges.
Taichiro Goto.
Vaccines (Basel), 2019 Aug 29; 7(3). PMID: 31455032    Free PMC article.
Molecular Modeling Studies on the Binding Mode of the PD-1/PD-L1 Complex Inhibitors.
Suliman Almahmoud, Haizhen A Zhong.
Int J Mol Sci, 2019 Sep 25; 20(18). PMID: 31546905    Free PMC article.
Cryoablation and Immunotherapy: An Enthralling Synergy to Confront the Tumors.
Chakradhar Yakkala, Cheryl Lai-Lai Chiang, +2 authors, Rafael Duran.
Front Immunol, 2019 Oct 15; 10. PMID: 31608067    Free PMC article.
The Diverse Function of PD-1/PD-L Pathway Beyond Cancer.
Weiting Qin, Lipeng Hu, +4 authors, Xu Wang.
Front Immunol, 2019 Oct 23; 10. PMID: 31636634    Free PMC article.
Highly Cited. Review.
Current Paradigms of Tolerogenic Dendritic Cells and Clinical Implications for Systemic Lupus Erythematosus.
Patcharee Ritprajak, Chamraj Kaewraemruaen, Nattiya Hirankarn.
Cells, 2019 Oct 24; 8(10). PMID: 31640263    Free PMC article.
Virus-Receptor Interactions: Structural Insights For Oncolytic Virus Development.
Nadishka Jayawardena, Laura N Burga, John T Poirier, Mihnea Bostina.
Oncolytic Virother, 2019 Nov 23; 8. PMID: 31754615    Free PMC article.
Impact of antiretroviral drugs on PD-L1 expression and copy number gains with clinical outcomes in HIV-positive and -negative locally advanced cervical cancers.
Kongsak Loharamtaweethong, Songkhun Vinyuvat, +3 authors, Napaporn Puripat.
Oncol Lett, 2019 Dec 04; 18(6). PMID: 31788048    Free PMC article.
In vitro Interactions of Chicken Programmed Cell Death 1 (PD-1) and PD-1 Ligand-1 (PD-L1).
Vishwanatha R A P Reddy, William Mwangi, Yashar Sadigh, Venugopal Nair.
Front Cell Infect Microbiol, 2020 Jan 11; 9. PMID: 31921710    Free PMC article.
Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy.
Steven L Highfill, Yongzhi Cui, +5 authors, Crystal L Mackall.
Sci Transl Med, 2014 May 23; 6(237). PMID: 24848257    Free PMC article.
Highly Cited.
Prevalence of programmed death-1 ligand-1 (PD-L1) and infiltrating lymphocytes in human gastric carcinogenesis.
Zhonghua Liu, Yufang Wang, +3 authors, Tao Wang.
Int J Clin Exp Pathol, 2017 Dec 01; 10(12). PMID: 31966537    Free PMC article.
Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?
Pilar M Lanuza, Cecilia Pesini, +3 authors, Julian Pardo.
Front Immunol, 2020 Jan 31; 10. PMID: 31998304    Free PMC article.
Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets.
Dan Li, Shixin Xiang, +12 authors, Qinglian Wen.
Int J Biol Sci, 2020 Feb 07; 16(4). PMID: 32025206    Free PMC article.
Engineering Newcastle Disease Virus as an Oncolytic Vector for Intratumoral Delivery of Immune Checkpoint Inhibitors and Immunocytokines.
Gayathri Vijayakumar, Stephen McCroskery, Peter Palese.
J Virol, 2019 Nov 07; 94(3). PMID: 31694938    Free PMC article.
Helminth Coinfection Alters Monocyte Activation, Polarization, and Function in Latent Mycobacterium tuberculosis Infection.
Anuradha Rajamanickam, Saravanan Munisankar, +3 authors, Subash Babu.
J Immunol, 2020 Jan 19; 204(5). PMID: 31953351    Free PMC article.
PDL1 blockage increases fetal resorption and Tfr cells but does not affect Tfh/Tfr ratio and B-cell maturation during allogeneic pregnancy.
Weihong Zeng, Shi Qin, +8 authors, Yi Lin.
Cell Death Dis, 2020 Feb 14; 11(2). PMID: 32051396    Free PMC article.
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Nicolas Palaskas, Juan Lopez-Mattei, +2 authors, Anita Deswal.
J Am Heart Assoc, 2020 Jan 22; 9(2). PMID: 31960755    Free PMC article.
CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.
Michael G Strainic, Jinbo Liu, +5 authors, M Edward Medof.
Am J Pathol, 2019 May 20; 189(7). PMID: 31103439    Free PMC article.
Immune recurrence score using 7 immunoregulatory protein expressions can predict recurrence in stage I-III breast cancer patients.
Dae-Won Lee, Han Suk Ryu, +14 authors, Seock-Ah Im.
Br J Cancer, 2019 Jul 12; 121(3). PMID: 31292534    Free PMC article.
CTLA-4 Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice.
Hilman Zulkifli Amin, Naoto Sasaki, +10 authors, Ken-Ichi Hirata.
Sci Rep, 2019 May 31; 9(1). PMID: 31147569    Free PMC article.
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma.
Megumi Goto, Kenji Chamoto, +17 authors, Tasuku Honjo.
Sci Rep, 2019 Jul 14; 9(1). PMID: 31300681    Free PMC article.
Interferon gamma inhibits CXCL8-CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer.
Mingjie Zhang, Lifeng Huang, +9 authors, Qiang Yan.
J Immunother Cancer, 2020 Feb 14; 8(1). PMID: 32051287    Free PMC article.
An update: emerging drugs to treat squamous cell carcinomas of the head and neck.
Yoon Se Lee, Daniel E Johnson, Jennifer R Grandis.
Expert Opin Emerg Drugs, 2018 Nov 01; 23(4). PMID: 30376740    Free PMC article.
Role of cytokine agonists and immune checkpoint inhibitors toward HIV remission.
Timothy N Hoang, Mirko Paiardini.
Curr Opin HIV AIDS, 2018 Dec 27; 14(2). PMID: 30585798    Free PMC article.
Isolation of immune-regulatory Tetragenococcus halophilus from miso.
Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi.
PLoS One, 2018 Dec 27; 13(12). PMID: 30586377    Free PMC article.
A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma.
Caroline E Nunes-Xavier, Javier C Angulo, Rafael Pulido, José I López.
Curr Urol Rep, 2019 Jan 16; 20(1). PMID: 30645700
Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape.
Xianjie Jiang, Jie Wang, +12 authors, Zhaoyang Zeng.
Mol Cancer, 2019 Jan 17; 18(1). PMID: 30646912    Free PMC article.
Highly Cited. Review.
Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist.
Kwi Hye Koh, Yanxia Cao, +12 authors, Eunsil Hahm.
J Clin Invest, 2019 Feb 13; 129(4). PMID: 30747722    Free PMC article.
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells.
Jessica Bourque, Daniel Hawiger.
Crit Rev Immunol, 2019 Feb 23; 38(5). PMID: 30792568    Free PMC article.
Highly Cited. Review.
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction.
Xindong Liu, Yun Wang, +26 authors, Chen Dong.
Nature, 2019 Mar 01; 567(7749). PMID: 30814730    Free PMC article.
Highly Cited.
Safety, Tolerability, and Potential Clinical Activity of a Glucocorticoid-Induced TNF Receptor-Related Protein Agonist Alone or in Combination With Nivolumab for Patients With Advanced Solid Tumors: A Phase 1/2a Dose-Escalation and Cohort-Expansion Clinical Trial.
Kimberley M Heinhuis, Matteo Carlino, +17 authors, Lillian L Siu.
JAMA Oncol, 2019 Nov 08; 6(1). PMID: 31697308    Free PMC article.
Possibilities of Improving the Clinical Value of Immune Checkpoint Inhibitor Therapies in Cancer Care by Optimizing Patient Selection.
Sanna Iivanainen, Jussi P Koivunen.
Int J Mol Sci, 2020 Jan 19; 21(2). PMID: 31952311    Free PMC article.
Effect of Glycine on BV-2 Microglial Cells Treated with Interferon-γ and Lipopolysaccharide.
Florentina Egger, Martin Jakab, +5 authors, Martin Gaisberger.
Int J Mol Sci, 2020 Jan 30; 21(3). PMID: 31991850    Free PMC article.
Comprehensive molecular profiling of the B7 family in gastrointestinal cancer.
Qijie Zhao, Fuyan Hu, +10 authors, Jing Shen.
Cell Prolif, 2018 Jul 13; 51(5). PMID: 29999557    Free PMC article.
Phenotypical and potential functional characteristics of different immune cells expressing CD28H/B7-H5 and their relationship with cancer prognosis.
C Zhong, Q Lang, +3 authors, Y Tian.
Clin Exp Immunol, 2020 Jan 05; 200(1). PMID: 31901178    Free PMC article.
Systematic Review.
Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates.
Hafiz Ishfaq Ahmad, Jiabin Zhou, +9 authors, Jinping Chen.
Aging (Albany NY), 2020 Feb 12; 12(4). PMID: 32045365    Free PMC article.
Characterization of the immune microenvironment in brain metastases from different solid tumors.
Jinling Jiang, Lihong Wu, +11 authors, Jun Zhang.
Cancer Med, 2020 Feb 06; 9(7). PMID: 32017467    Free PMC article.
The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals.
Elliot A Philips, Antonio Garcia-España, +5 authors, Xiang-Peng Kong.
J Biol Chem, 2019 Dec 29; 295(14). PMID: 31882544    Free PMC article.
A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy.
Kripa Guram, Sangwoo S Kim, +6 authors, Andrew B Sharabi.
Front Immunol, 2019 Apr 03; 10. PMID: 30936880    Free PMC article.
A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques.
Gospel Enyindah-Asonye, Anthony Nwankwo, +7 authors, Marjorie Robert-Guroff.
Front Immunol, 2019 Apr 04; 10. PMID: 30941141    Free PMC article.
Adoptive Cell Therapy-Harnessing Antigen-Specific T Cells to Target Solid Tumours.
Elżbieta Chruściel, Zuzanna Urban-Wójciuk, +10 authors, Natalia Marek-Trzonkowska.
Cancers (Basel), 2020 Mar 19; 12(3). PMID: 32183246    Free PMC article.
Staphylococcal and Streptococcal Superantigens Trigger B7/CD28 Costimulatory Receptor Engagement to Hyperinduce Inflammatory Cytokines.
Andrey Popugailo, Ziv Rotfogel, +2 authors, Raymond Kaempfer.
Front Immunol, 2019 May 23; 10. PMID: 31114583    Free PMC article.
CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine.
Roberto S Accolla, Elise Ramia, Alessandra Tedeschi, Greta Forlani.
Front Immunol, 2019 Aug 17; 10. PMID: 31417570    Free PMC article.
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
Jun Wang, Jingwei Sun, +16 authors, Lieping Chen.
Nat Med, 2019 Mar 06; 25(4). PMID: 30833750    Free PMC article.
Highly Cited.
CTLA4-Ig Abatacept Ameliorates Proteinuria by Regulating Circulating Treg/IL-17 in Adriamycin-Induced Nephropathy Rats.
Lanjun Shuai, Qia Cheng, +2 authors, Xiaochuan Wu.
Biomed Res Int, 2020 May 19; 2020. PMID: 32420329    Free PMC article.
Friend or Foe? Recent Strategies to Target Myeloid Cells in Cancer.
Mehdi Chaib, Subhash C Chauhan, Liza Makowski.
Front Cell Dev Biol, 2020 Jun 09; 8. PMID: 32509781    Free PMC article.
Identification of methylation-driven genes related to the prognosis of papillary renal cell carcinoma: a study based on The Cancer Genome Atlas.
Zeyu Liu, Yuxiang Wan, +4 authors, Jingnan Xu.
Cancer Cell Int, 2020 Jun 17; 20. PMID: 32536823    Free PMC article.
Mechanistic insight of predictive biomarkers for antitumor PD‑1/PD‑L1 blockade: A paradigm shift towards immunome evaluation (Review).
Wenjie You, Bin Shang, +3 authors, Shujuan Jiang.
Oncol Rep, 2020 Jul 07; 44(2). PMID: 32627031    Free PMC article.
[The research progress of costimulatory molecule B7 family in hematological malignancy].
Wei Zhang, Fei Dong, Xiaoyan Ke.
Zhonghua Xue Ye Xue Za Zhi, 2015 Aug 26; 36(7). PMID: 26304094    Free PMC article.
Advanced Foot-And-Mouth Disease Vaccine Platform for Stimulation of Simultaneous Cellular and Humoral Immune Responses.
Min Ja Lee, Hyundong Jo, +4 authors, Jong-Hyeon Park.
Vaccines (Basel), 2020 Jun 03; 8(2). PMID: 32481687    Free PMC article.
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.
Selena Vigano, Sara Bobisse, +2 authors, Alexandre Harari.
Front Immunol, 2020 Jul 28; 11. PMID: 32714330    Free PMC article.
Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-κB (P65) Pathway in Hepatocellular Carcinoma Cells.
Qiu-Ting Li, Meng-Jun Qiu, +6 authors, Shanshan Huang.
J Oncol, 2020 Aug 11; 2020. PMID: 32774373    Free PMC article.
The Ways of Isolating Neoantigen-Specific T Cells.
Qing Li, Zhen-Yu Ding.
Front Oncol, 2020 Aug 28; 10. PMID: 32850430    Free PMC article.
Progress in immunotherapy for small cell lung cancer.
Dong Zhao, Bing Xie, +3 authors, Qiang Lin.
World J Clin Oncol, 2020 Sep 03; 11(6). PMID: 32874950    Free PMC article.
Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis.
Chenxin Qie, Jingwei Jiang, +4 authors, Jun Liu.
Theranostics, 2020 Sep 16; 10(23). PMID: 32929361    Free PMC article.
Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma.
Michael R Olin, Elisabet Ampudia-Mesias, +5 authors, G Elizabeth Pluhar.
Cancers (Basel), 2019 Jan 27; 11(2). PMID: 30682795    Free PMC article.
Role of Anti-PD-1 Antibodies in Advanced Melanoma: The Era of Immunotherapy.
Sakshi Sahni, Gautam Valecha, Ankit Sahni.
Cureus, 2019 Feb 23; 10(12). PMID: 30788189    Free PMC article.
Making cold malignant pleural effusions hot: driving novel immunotherapies.
Pranav Murthy, Chigozirim N Ekeke, +6 authors, Michael T Lotze.
Oncoimmunology, 2019 Mar 25; 8(4). PMID: 30906651    Free PMC article.
Tailoring Ovarian Cancer Treatment: Implications of BRCA1/2 Mutations.
Ainhoa Madariaga, Stephanie Lheureux, Amit M Oza.
Cancers (Basel), 2019 Mar 27; 11(3). PMID: 30909618    Free PMC article.
Oncolytic Viruses and Immune Checkpoint Inhibition: The Best of Both Worlds.
Venkatesh Sivanandam, Christopher J LaRocca, +2 authors, Susanne G Warner.
Mol Ther Oncolytics, 2019 May 14; 13. PMID: 31080879    Free PMC article.
Highly Cited. Review.
A PD-L1-Based Cancer Vaccine Elicits Antitumor Immunity in a Mouse Melanoma Model.
Zhibing Lin, Yan Zhang, +4 authors, Rongxiu Li.
Mol Ther Oncolytics, 2019 Aug 07; 14. PMID: 31384666    Free PMC article.
Checkpoint inhibition in advanced gastroesophageal cancer: clinical trial data, molecular subtyping, predictive biomarkers, and the potential of combination therapies.
Jeremy Chuang, Joseph Chao, +2 authors, Jun Gong.
Transl Gastroenterol Hepatol, 2019 Sep 29; 4. PMID: 31559344    Free PMC article.
Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy.
Leilei Ai, Jian Chen, +4 authors, Xiaochun Yang.
Drug Des Devel Ther, 2020 Sep 29; 14. PMID: 32982171    Free PMC article.
ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases.
Dan-Yang Li, Xian-Zhi Xiong.
Front Immunol, 2020 Sep 29; 11. PMID: 32983168    Free PMC article.

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Rev Malad Respir Actual, 2020 Oct 13; 12(2). PMID: 33042321    Free PMC article.
Synergistic effect of programmed death-1 inhibitor and programmed death-1 ligand-1 inhibitor combined with chemotherapeutic drugs on DLBCL cell lines in vitro and in vivo.
Rui Zhang, Cuicui Lyu, +3 authors, Qi Deng.
Am J Cancer Res, 2020 Oct 13; 10(9). PMID: 33042618    Free PMC article.
The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines.
Meng-Ya Shi, Min Li, +6 authors, Ping Wei.
Viruses, 2020 Sep 24; 12(9). PMID: 32962247    Free PMC article.
Cellular Signaling Pathways in Medium and Large Vessel Vasculitis.
Ryu Watanabe, Gerald J Berry, +2 authors, Cornelia M Weyand.
Front Immunol, 2020 Oct 20; 11. PMID: 33072134    Free PMC article.
Overcoming Tumor-Induced Immune Suppression: From Relieving Inhibition to Providing Costimulation with T Cell Agonists.
Dana A Emerson, William L Redmond.
BioDrugs, 2018 Apr 11; 32(3). PMID: 29637478    Free PMC article.
B7-H6, an immunoligand for the natural killer cell activating receptor NKp30, reveals inhibitory effects on cell proliferation and migration, but not apoptosis, in cervical cancer derived-cell lines.
Nehla Banu, Annie Riera-Leal, +10 authors, Susana Del Toro-Arreola.
BMC Cancer, 2020 Nov 12; 20(1). PMID: 33172426    Free PMC article.
Sulforaphane Promotes Dendritic Cell Stimulatory Capacity Through Modulation of Regulatory Molecules, JAK/STAT3- and MicroRNA-Signaling.
Yangyi Wang, Emilia Petrikova, +4 authors, Svetlana Karakhanova.
Front Immunol, 2020 Nov 17; 11. PMID: 33193420    Free PMC article.
Usefulness of the cytokines expression of Th1/Th2/Th17 and urinary CD80 excretion in adult-onset minimal change disease.
Ping Chen, Yan Chen, +4 authors, Jun Zhang.
PeerJ, 2020 Nov 17; 8. PMID: 33194357    Free PMC article.
CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway.
Rui Cheng, Bi Wang, +5 authors, Yan-Ling Chen.
Onco Targets Ther, 2020 Nov 19; 13. PMID: 33204103    Free PMC article.
Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors.
Maddalena Centanni, Dirk Jan A R Moes, +2 authors, J G Coen van Hasselt.
Clin Pharmacokinet, 2019 Mar 01; 58(7). PMID: 30815848    Free PMC article.
Highly Cited. Review.
Apoptosis of antigen-specific CTLs contributes to low immune response in gut-associated lymphoid tissue post vaccination.
Masaru Shimada, Shinji Yoshizaki, +2 authors, Kenji Okuda.
Vaccine, 2014 Jul 30; 32(40). PMID: 25066739    Free PMC article.
Anti-OX40L alone or in combination with anti-CD40L and CTLA4Ig does not inhibit the humoral and cellular response to a major grass pollen allergen.
M Gattringer, U Baranyi, +6 authors, T Wekerle.
Clin Exp Allergy, 2015 Oct 16; 46(2). PMID: 26464312    Free PMC article.
A Quantitative Comparison of Antibodies to Programmed Cell Death 1 Ligand 1.
Patricia Gaule, James W Smithy, +7 authors, David L Rimm.
JAMA Oncol, 2016 Aug 20; 3(2). PMID: 27541827    Free PMC article.
Highly Cited.
Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer?
Mathieu Césaire, Juliette Thariat, +3 authors, François Chevalier.
Int J Mol Sci, 2018 Nov 30; 19(12). PMID: 30487462    Free PMC article.
Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways.
Elisaveta Voynova, Tamer Mahmoud, +3 authors, Helen Braley-Mullen.
Immunohorizons, 2019 Jan 05; 2(1). PMID: 30607385    Free PMC article.
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives.
Yumeng Wang, Guiling Li.
Front Med, 2019 Mar 04; 13(4). PMID: 30826965
Understanding Immune Evasion and Therapeutic Targeting Associated with PD-1/PD-L1 Pathway in Diffuse Large B-cell Lymphoma.
Moo-Kon Song, Byeong-Bae Park, Jieun Uhm.
Int J Mol Sci, 2019 Mar 20; 20(6). PMID: 30884772    Free PMC article.
Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology.
Hyun Tae Lee, Sang Hyung Lee, Yong-Seok Heo.
Molecules, 2019 Mar 29; 24(6). PMID: 30917623    Free PMC article.
Clinical development of targeted and immune based anti-cancer therapies.
N A Seebacher, A E Stacy, G M Porter, A M Merlot.
J Exp Clin Cancer Res, 2019 Apr 13; 38(1). PMID: 30975211    Free PMC article.
Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes.
Peng Sun, Qingyan Jin, +4 authors, Fang Guo.
J Diabetes Res, 2019 Apr 23; 2019. PMID: 31008114    Free PMC article.
The Expression Patterns and Associated Clinical Parameters of Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 and Transmembrane and Immunoglobulin Domain Containing 2 in Oral Squamous Cell Carcinoma.
Yao Xiao, Hao Li, +4 authors, Zhi-Jun Sun.
Dis Markers, 2019 May 16; 2019. PMID: 31089395    Free PMC article.
Progress on chicken T cell immunity to viruses.
Manman Dai, Chenggang Xu, Weisan Chen, Ming Liao.
Cell Mol Life Sci, 2019 May 19; 76(14). PMID: 31101935
Dedifferentiated Endometrial Carcinoma Could be A Target for Immune Checkpoint Inhibitors (Anti PD-1/PD-L1 Antibodies).
Ruriko Ono, Kentaro Nakayama, +11 authors, Satoru Kyo.
Int J Mol Sci, 2019 Aug 03; 20(15). PMID: 31370215    Free PMC article.
Tolerance induction in memory CD4 T cells is partial and reversible.
Joshua I Gray, Shaima Al-Khabouri, +8 authors, Megan K L MacLeod.
Immunology, 2020 Sep 16; 162(1). PMID: 32931017    Free PMC article.
SNP-SNP Interaction in Genes Encoding PD-1/PD-L1 Axis as a Potential Risk Factor for Clear Cell Renal Cell Carcinoma.
Marta Wagner, Krzysztof Tupikowski, +7 authors, Lidia Karabon.
Cancers (Basel), 2020 Dec 02; 12(12). PMID: 33255938    Free PMC article.
Immunomodulatory Effects of Recombinant Mycobacterium smegmatis Expressing Antigen-85B Epitopes in Infected J774A.1 Murine Macrophages.
Nur-Ayuni Kadir, Armando Acosta, Maria E Sarmiento, Mohd-Nor Norazmi.
Pathogens, 2020 Dec 03; 9(12). PMID: 33260418    Free PMC article.
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein.
Min Thura, Abdul Qader Al-Aidaroos, +26 authors, Qi Zeng.
Nat Commun, 2019 Jun 07; 10(1). PMID: 31171773    Free PMC article.
MicroRNAs as Biomarkers for Nephrotic Syndrome.
Kenji Tsuji, Shinji Kitamura, Jun Wada.
Int J Mol Sci, 2020 Dec 31; 22(1). PMID: 33374848    Free PMC article.
Therapeutic Approaches for Metastases from Colorectal Cancer and Pancreatic Ductal Carcinoma.
Adriana G Quiroz-Reyes, Jose F Islas, +2 authors, Elsa N Garza-Treviño.
Pharmaceutics, 2021 Jan 21; 13(1). PMID: 33466892    Free PMC article.
The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.
Nicholas J Maurice, Alexis K Taber, Martin Prlic.
J Immunol, 2021 Jan 21; 206(3). PMID: 33468558    Free PMC article.
A Comprehensive Prognostic and Immune Analysis of SLC41A3 in Pan-Cancer.
Jun Liu, Shanqiang Zhang, +2 authors, Ji-Cheng Li.
Front Oncol, 2021 Feb 02; 10. PMID: 33520701    Free PMC article.
Identification of a prognostic and therapeutic immune signature associated with hepatocellular carcinoma.
Yanan Peng, Chang Liu, +7 authors, Qiu Zhao.
Cancer Cell Int, 2021 Feb 12; 21(1). PMID: 33568167    Free PMC article.
Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET.
Federico Simonetta, Israt S Alam, +20 authors, Robert S Negrin.
Clin Cancer Res, 2020 Oct 23; 27(4). PMID: 33087332    Free PMC article.
Varied functions of immune checkpoints during cancer metastasis.
Ali Safarzadeh, Mohsen Alizadeh, +7 authors, Nicola Silvestris.
Cancer Immunol Immunother, 2020 Sep 10; 70(3). PMID: 32902664    Free PMC article.
Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms.
Arta M Monjazeb, Ziming Wang, +4 authors, William J Murphy.
Cancers (Basel), 2021 Feb 14; 13(4). PMID: 33578798    Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage.
Yuan Hong, Yingcai Feng, +12 authors, Ye Liu.
FEBS Open Bio, 2021 Feb 03; 11(3). PMID: 33527708    Free PMC article.
Recent Advances in Costimulatory Blockade to Induce Immune Tolerance in Liver Transplantation.
Mingjie Ding, Yuting He, Shuijun Zhang, Wenzhi Guo.
Front Immunol, 2021 Mar 19; 12. PMID: 33732228    Free PMC article.
Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30.
Allison Kinlein, Morgan E Janes, +6 authors, Yuko Ohta.
Immunogenetics, 2021 Mar 21; 73(4). PMID: 33742259    Free PMC article.
CLTA-4 Expression is Associated with the Maintenance of Chronic Inflammation in Endometriosis and Infertility.
Monika Abramiuk, Dominika Bębnowska, +4 authors, Ewelina Grywalska.
Cells, 2021 Mar 07; 10(3). PMID: 33668701    Free PMC article.
Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma.
Byung Min Lee, Jinsil Seong.
World J Gastroenterol, 2021 Mar 30; 27(10). PMID: 33776363    Free PMC article.
Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens.
Efthymia Papalexi, Eleni P Mimitou, +8 authors, Rahul Satija.
Nat Genet, 2021 Mar 03; 53(3). PMID: 33649593    Free PMC article.
Anti-CD19 CAR T cells potently redirected to kill solid tumor cells.
Christine Ambrose, Lihe Su, +8 authors, Paul D Rennert.
PLoS One, 2021 Mar 19; 16(3). PMID: 33735268    Free PMC article.
Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma.
Charles R Schutt, Hua Sun, +6 authors, Brian A Van Tine.
Oncotarget, 2021 Apr 03; 12(6). PMID: 33796222    Free PMC article.
Immune System Alterations in Multiple Myeloma: Molecular Mechanisms and Therapeutic Strategies to Reverse Immunosuppression.
Andrea Díaz-Tejedor, Mauro Lorenzo-Mohamed, +4 authors, Teresa Paíno.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33802806    Free PMC article.
Novel Diagnostics and Therapeutics in Sepsis.
Kieran Leong, Bhavita Gaglani, Ashish K Khanna, Michael T McCurdy.
Biomedicines, 2021 Apr 04; 9(3). PMID: 33803628    Free PMC article.
Thyroid Dysfunction in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors (ICIs): Outcomes in a Multiethnic Urban Cohort.
Angelica D'Aiello, Juan Lin, +5 authors, Balazs Halmos.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33806774    Free PMC article.
Immune Inhibitory Properties and Therapeutic Prospects of Transforming Growth Factor-Beta and Interleukin 10 in Autoimmune Hepatitis.
Albert J Czaja.
Dig Dis Sci, 2021 Apr 10; 67(4). PMID: 33835375
Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression.
Nghiem Xuan Hoan, Pham Thi Minh Huyen, +9 authors, Le Huu Song.
Sci Rep, 2021 Apr 10; 11(1). PMID: 33833369    Free PMC article.
The Role of CD276 in Cancers.
Shengzhuo Liu, Jiayu Liang, +9 authors, Xianding Wang.
Front Oncol, 2021 Apr 13; 11. PMID: 33842369    Free PMC article.
Combination CTLA-4 immunoglobulin treatment and ultrasound microbubble-mediated exposure improve renal function in a rat model of diabetic nephropathy.
Liang Wang, Pengfei Wang, +7 authors, Chunpeng Zou.
Aging (Albany NY), 2021 Mar 14; 13(6). PMID: 33714204    Free PMC article.
Programmed Death-1/Programmed Death-Ligand 1-Axis Blockade in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Stratified by Human Papillomavirus Status: A Systematic Review and Meta-Analysis.
Yimin Xu, Gangcai Zhu, +6 authors, Xin Zhang.
Front Immunol, 2021 Apr 27; 12. PMID: 33897693    Free PMC article.
Systematic Review.
PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment.
Tomohiro Takehara, Ei Wakamatsu, +6 authors, Tadashi Yokosuka.
Commun Biol, 2021 May 16; 4(1). PMID: 33990697    Free PMC article.
Immunosuppressive Mechanisms of Regulatory B Cells.
Diego Catalán, Miguel Andrés Mansilla, +4 authors, Octavio Aravena.
Front Immunol, 2021 May 18; 12. PMID: 33995344    Free PMC article.
T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals.
Stefano Rinaldi, Lesley de Armas, +16 authors, EPIICAL consortium.
PLoS Pathog, 2021 Apr 27; 17(4). PMID: 33901266    Free PMC article.
Targeting Epigenetics to Cure HIV-1: Lessons From (and for) Cancer Treatment.
J Peter Svensson.
Front Cell Infect Microbiol, 2021 May 25; 11. PMID: 34026665    Free PMC article.
Modulation of the immune microenvironment of high-risk ductal carcinoma in situ by intralesional pembrolizumab injection.
Alexa C Glencer, Jasmine M Wong, +7 authors, Michael J Campbell.
NPJ Breast Cancer, 2021 May 27; 7(1). PMID: 34035311    Free PMC article.
Current Prospects for Treatment of Solid Tumors via Photodynamic, Photothermal, or Ionizing Radiation Therapies Combined with Immune Checkpoint Inhibition (A Review).
Sanjay Anand, Timothy A Chan, Tayyaba Hasan, Edward V Maytin.
Pharmaceuticals (Basel), 2021 Jun 03; 14(5). PMID: 34068491    Free PMC article.
Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development.
Seyed Hossein Kiaie, Mohammad Javad Sanaei, +5 authors, Behzad Baradaran.
Acta Pharm Sin B, 2021 Jun 08; 11(5). PMID: 34094821    Free PMC article.
The potential of adoptive transfer of γ9δ2 T cells to enhance blinatumomab's antitumor activity against B-cell malignancy.
Yun-Hsiang Chen, Yun Wang, Cheng-Hao Liao, Shu-Ching Hsu.
Sci Rep, 2021 Jun 13; 11(1). PMID: 34117317    Free PMC article.
Immunotherapy in endometrial cancer: rationale, practice and perspectives.
Wenyu Cao, Xinyue Ma, +3 authors, Qing Zhang.
Biomark Res, 2021 Jun 18; 9(1). PMID: 34134781    Free PMC article.
Hepatocellular cancer therapy in patients with HIV infection: Disparities in cancer care, trials enrolment, and cancer-related research.
Francesca Negri, Gabriele Missale, Anna Degli Antoni, Camillo Porta.
Transl Oncol, 2021 Jun 19; 14(9). PMID: 34144349    Free PMC article.
Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Potential Improved Outcomes.
João C D Muzzi, Jessica M Magno, +3 authors, Bonald C Figueiredo.
Front Endocrinol (Lausanne), 2021 Jul 02; 12. PMID: 34194394    Free PMC article.
Leishmania Parasites Drive PD-L1 Expression in Mice and Human Neutrophils With Suppressor Capacity.
Alessandra M da Fonseca-Martins, Phillipe de Souza Lima-Gomes, +9 authors, Herbert L de Matos Guedes.
Front Immunol, 2021 Jul 03; 12. PMID: 34211455    Free PMC article.
Macrophage Plasticity and Polarization Are Altered in the Experimental Model of Multiple Sclerosis.
Alessandro Leuti, Emanuela Talamonti, +5 authors, Valerio Chiurchiù.
Biomolecules, 2021 Jul 03; 11(6). PMID: 34200023    Free PMC article.
DCision-making in tumors governs T cell anti-tumor immunity.
Francesca Alfei, Ping-Chih Ho, Wan-Lin Lo.
Oncogene, 2021 Jul 23; 40(34). PMID: 34290401    Free PMC article.
Early Transcriptional Liver Signatures in Experimental Visceral Leishmaniasis.
Génesis Palacios, Raquel Diaz-Solano, +2 authors, Emma Carmelo.
Int J Mol Sci, 2021 Jul 21; 22(13). PMID: 34281214    Free PMC article.
Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review.
Shujing Liang, Jingxian Yang, +4 authors, Chunyan Dong.
Front Immunol, 2021 Jul 27; 12. PMID: 34305915    Free PMC article.
Immunotherapy-Related Imaging Findings in Patients with Gynecological Malignancies: What Radiologists Need to Know.
Luca Russo, Giacomo Avesani, +7 authors, Riccardo Manfredi.
Korean J Radiol, 2021 May 29; 22(8). PMID: 34047505    Free PMC article.
Re-Programming Autoreactive T Cells Into T-Regulatory Type 1 Cells for the Treatment of Autoimmunity.
Patricia Solé, Pere Santamaria.
Front Immunol, 2021 Aug 03; 12. PMID: 34335585    Free PMC article.
Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA.
Ting-Ting Li, Jing-Wei Jiang, +5 authors, Jun Liu.
BMC Immunol, 2021 Aug 13; 22(1). PMID: 34380434    Free PMC article.
Characterization of local and peripheral immune system in pregnant and nonpregnant ewes.
Laurel D Quirke, Paul H Maclean, +3 authors, Jennifer L Juengel.
J Anim Sci, 2021 Jul 10; 99(8). PMID: 34240172    Free PMC article.
Cryptic association of B7-2 molecules and its implication for clustering.
Swetha Lankipalli, Mahadeva Swamy H S, +3 authors, Udupi A Ramagopal.
Protein Sci, 2021 Jul 01; 30(9). PMID: 34191384    Free PMC article.
B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors.
Petar Rasic, Maja Jovanovic-Tucovic, +4 authors, Djordje Savic.
World J Gastrointest Oncol, 2021 Aug 31; 13(8). PMID: 34457187    Free PMC article.
Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation.
Harry H Matundan, Ujjaldeep Jaggi, +2 authors, Homayon Ghiasi.
mBio, 2021 Jul 21; 12(4). PMID: 34281386    Free PMC article.
Immunotherapy in Gastroesophageal Cancers: Current Evidence and Ongoing Trials.
Jasmine Huynh, Kanishka Patel, +4 authors, Samuel Klempner.
Curr Treat Options Oncol, 2021 Sep 16; 22(11). PMID: 34524553
PD-1-stimulated T cell subsets are transcriptionally and functionally distinct.
Shalom Lerrer, Anna S Tocheva, +2 authors, Adam Mor.
iScience, 2021 Sep 16; 24(9). PMID: 34522863    Free PMC article.
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy.
Jinhua Liu, Zichao Chen, +3 authors, Zhen Zhang.
Front Pharmacol, 2021 Sep 21; 12. PMID: 34539412    Free PMC article.
The Anti-PD-1/PD-L1 Immunotherapy for Gastric Esophageal Cancer: A Systematic Review and Meta-Analysis and Literature Review.
Ke Chen, Xiao Wang, Liu Yang, Zheling Chen.
Cancer Control, 2021 Feb 24; 28. PMID: 33618535    Free PMC article.
Systematic Review.
Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment.
Hridesh Banerjee, Hector Nieves-Rosado, +9 authors, Lawrence P Kane.
Cell Rep, 2021 Sep 16; 36(11). PMID: 34525351    Free PMC article.
Recombinant Avian β-Defensin Produced by Food-Grade Lactococcus as a Novel and Potent Immunological Enhancer Adjuvant for Avian Vaccine.
Tingting Wang, Zhihao Wang, +10 authors, Hongyu Cui.
Probiotics Antimicrob Proteins, 2021 Oct 02; 13(6). PMID: 34595668    Free PMC article.
Safety and Efficacy of Anti-CD19-Chimeric Antigen Receptor T Cell Combined With Programmed Cell Death 1 Inhibitor Therapy in a Patient With Refractory Post-Transplant Lymphoproliferative Disease: Case Report and Literature Review.
Gang Feng, Qing Li, +4 authors, Qi Deng.
Front Oncol, 2021 Oct 05; 11. PMID: 34604065    Free PMC article.
The GPR171 pathway suppresses T cell activation and limits antitumor immunity.
Yuki Fujiwara, Robert J Torphy, +8 authors, Yuwen Zhu.
Nat Commun, 2021 Oct 08; 12(1). PMID: 34615877    Free PMC article.
Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy.
Shubhangi Gavali, Jianing Liu, Xinyi Li, Magdalena Paolino.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639141    Free PMC article.
PD-1-induced proliferating T cells exhibit a distinct transcriptional signature.
Marianne Strazza, Shoiab Bukhari, Anna S Tocheva, Adam Mor.
Immunology, 2021 Jun 25; 164(3). PMID: 34164813    Free PMC article.
Emerging targets for anticancer vaccination: PD-1.
J Tobias, P Steinberger, M Drinić, U Wiedermann.
ESMO Open, 2021 Oct 15; 6(5). PMID: 34649221    Free PMC article.
Soluble B7-H5 Is a Novel Diagnostic, Severity, and Prognosis Marker in Acute Pancreatitis.
Ruoxin Xu, Ju Gong, +2 authors, Jian Huang.
Biomed Res Int, 2021 Oct 19; 2021. PMID: 34660778    Free PMC article.
The Immune System in Duchenne Muscular Dystrophy Pathogenesis.
Luana Tripodi, Chiara Villa, +2 authors, Andrea Farini.
Biomedicines, 2021 Oct 24; 9(10). PMID: 34680564    Free PMC article.
Clinical Impact of X-Ray Repair Cross-Complementary 1 (XRCC1) and the Immune Environment in Colorectal Adenoma-Carcinoma Pathway Progression.
Yu Zhang, Xin Zhang, +5 authors, Wensheng Pan.
J Inflamm Res, 2021 Nov 06; 14. PMID: 34737598    Free PMC article.
Prognostic significance of HSF2BP in lung adenocarcinoma.
Zhendong Huang, Zhendong Liu, +5 authors, Li Wei.
Ann Transl Med, 2021 Nov 19; 9(20). PMID: 34790765    Free PMC article.
Potential Biomarkers for the Efficacy of PD-1-PD-L Blockade in Cancer.
Miruna Grecea, Olga Soritau, +2 authors, Mihnea Zdrenghea.
Onco Targets Ther, 2021 Dec 02; 14. PMID: 34848970    Free PMC article.
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.
Wen Li, Feifei Li, +2 authors, Chuan Xu.
Signal Transduct Target Ther, 2021 Dec 21; 6(1). PMID: 34924561    Free PMC article.
The developing landscape of combinatorial therapies of immune checkpoint blockade with DNA damage repair inhibitors for the treatment of breast and ovarian cancers.
Lingling Zhu, Jiewei Liu, Jiang Chen, Qinghua Zhou.
J Hematol Oncol, 2021 Dec 22; 14(1). PMID: 34930377    Free PMC article.
Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis.
Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake.
J Clin Med, 2021 Dec 25; 10(24). PMID: 34945203    Free PMC article.
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy.
Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern.
Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146    Free PMC article.
pH Low Insertion Peptide-Modified Programmed Cell Death-Ligand 1 Potently Suppresses T-Cell Activation Under Acidic Condition.
Ying Sun, Linhan Hu, +11 authors, Guojiang Chen.
Front Immunol, 2022 Jan 11; 12. PMID: 35003115    Free PMC article.
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Meiyun Sun, Jinjing Xie, +4 authors, Guangbo Zhang.
J Cancer, 2022 Jan 11; 12(24). PMID: 35003371    Free PMC article.
TGFβ2 Induces the Soluble Isoform of CTLA-4 - Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma.
Rahul C Khanolkar, Chu Zhang, +11 authors, Frank James Ward.
Front Immunol, 2022 Jan 25; 12. PMID: 35069536    Free PMC article.
Association of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis.
Mehtap Cevik, Esat Namal, +4 authors, Belgin Susleyici.
Mol Biol Rep, 2022 Jan 26; 49(3). PMID: 35076848
IL-35 inhibits CD8+ T cells activity by suppressing expression of costimulatory molecule CD28 and Th1 cytokine production.
Hua Jiang, Ting Zhang, Mao-Xiao Yan, Wei Wu.
Transl Cancer Res, 2019 Aug 01; 8(4). PMID: 35116874    Free PMC article.
An improved method to build lung cancer PDX models by surgical resection samples and its association with B7-H3 expression.
Yuxuan Wang, Biao Zhang, Haitao Huang, Tingjing Wang.
Transl Cancer Res, 2019 Dec 01; 8(8). PMID: 35117042    Free PMC article.
B7H3 expression and significance in idiopathic pulmonary fibrosis.
Chuling Fang, Andrew E Rinke, +3 authors, Tianju Liu.
J Pathol, 2021 Nov 27; 256(3). PMID: 34825713    Free PMC article.
Gangliosides in T cell development and function of mice.
Jin-Ichi Inokuchi, Masakazu Nagafuku.
Glycoconj J, 2022 Feb 15; 39(2). PMID: 35156158
GILT Expression in Human Melanoma Cells Enhances Generation of Antigenic Peptides for HLA Class II-Mediated Immune Recognition.
Jessica D Hathaway-Schrader, Duncan Norton, +5 authors, Azizul Haque.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35162988    Free PMC article.
Pivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancer.
Alexandr V Bazhin, Katharina von Ahn, +6 authors, Svetlana Karakhanova.
Oncoimmunology, 2022 Mar 08; 11(1). PMID: 35251770    Free PMC article.
Nano vaccines for T. gondii Ribosomal P2 Protein With Nanomaterials as a Promising DNA Vaccine Against Toxoplasmosis.
ZhengQing Yu, Ke He, +5 authors, XiangRui Li.
Front Immunol, 2022 Mar 11; 13. PMID: 35265084    Free PMC article.
SLAMF1 Is Dispensable for Vaccine-Induced T Cell Development but Required for Resistance to Fungal Infection.
Elaine M Kohn, Lucas Dos Santos Dias, +4 authors, Marcel Wüthrich.
J Immunol, 2022 Feb 27; 208(6). PMID: 35217584    Free PMC article.
Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.
Sofia Raftopoulou, Paulina Valadez-Cosmes, +2 authors, Julia Kargl.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328639    Free PMC article.
Circulating PD-1 mRNA in Peripheral Blood is a Potential Biomarker for Predicting Survival of Breast Cancer Patients.
Miwa Noda, Takaaki Masuda, +9 authors, Koshi Mimori.
Ann Surg Oncol, 2020 Mar 25; 27(10). PMID: 32206951
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.
Karin H Simons, Alwin de Jong, +3 authors, Paul H A Quax.
Nat Rev Cardiol, 2019 Feb 17; 16(6). PMID: 30770894
TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy.
Eugene Y Chiang, Ira Mellman.
J Immunother Cancer, 2022 Apr 06; 10(4). PMID: 35379739    Free PMC article.
Expression of the Costimulatory Molecule B7-H4 in the Decidua and Placental Tissues in Patients with Placental Abruption.
Monika Bączkowska, Magdalena Maria Dutsch-Wicherek, +5 authors, Michał Ciebiera.
Biomedicines, 2022 Apr 24; 10(4). PMID: 35453668    Free PMC article.
Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion.
Yang Liu, Lulu Wang, +13 authors, Dawen Zhao.
Nat Nanotechnol, 2021 Dec 18; 17(2). PMID: 34916656    Free PMC article.
Signal pathways and precision therapy of small-cell lung cancer.
Min Yuan, Yu Zhao, +3 authors, Qing Xu.
Signal Transduct Target Ther, 2022 Jun 16; 7(1). PMID: 35705538