. 2005 Mar; 5(4):343-9.
doi: 10.1038/nri1574.

Regulatory T-cell therapy: is it ready for the clinic?

Jeffrey A Bluestone 1 
  • PMID: 15775994
  •     56 citations


The identification of suppressor T cells as important regulators of basic processes that are designed to maintain tolerance has opened an important area of potential clinical investigation in autoimmunity, graft-versus-host disease and transplantation. However, the field has been limited by an inability to define the antigenic specificities of these cells and by the small numbers of circulating regulatory T cells. Recently, new methods for expanding polyclonal and antigen-specific regulatory T cells have emerged. This article summarizes efforts to exploit regulatory T-cell therapy for the treatment of immunological diseases and poses the question of when and where regulatory T cells will first impact on clinical diseases.

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Loss of Jak2 protects cardiac allografts from chronic rejection by attenuating Th1 response along with increased regulatory T cells.
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IFN-? stimulated dental follicle mesenchymal stem cells regulate activated lymphocyte response in rheumatoid arthritis patients in vitro.
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β‑Diketonate-Iron(III) Complex: A Versatile Fluorine-19 MRI Signal Enhancement Agent.
Chao Wang, Stephen R Adams, +2 authors, Eric T Ahrens.
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Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice.
Seon-Young Park, HyeJin Yang, +4 authors, Hyunsu Bae.
J Neuroinflammation, 2022 Jun 12; 19(1). PMID: 35690816