. 2005 May; 5(5):341-54.
doi: 10.1038/nrc1609.

ERBB receptors and cancer: the complexity of targeted inhibitors

Nancy E Hynes 1 Heidi A Lane  
  • PMID: 15864276
  •     1171 citations


ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.

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PLoS Med, 2005 Nov 18; 2(11). PMID: 16288556    Free PMC article.
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Highly Cited.
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Highly Cited.
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Clin Cancer Res, 2007 Dec 21; 13(24). PMID: 18094409    Free PMC article.
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Highly Cited. Review.
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PLoS One, 2008 Feb 14; 3(2). PMID: 18270579    Free PMC article.
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Br J Cancer, 2008 Feb 20; 98(6). PMID: 18283314    Free PMC article.
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Neoplasia, 2008 Feb 20; 10(2). PMID: 18283333    Free PMC article.
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J Cell Mol Med, 2008 Mar 06; 12(5A). PMID: 18318691    Free PMC article.
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Br J Cancer, 2008 Mar 06; 98(5). PMID: 18319715    Free PMC article.
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Structure, 2008 Mar 13; 16(3). PMID: 18334220    Free PMC article.
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Proc Natl Acad Sci U S A, 2008 Mar 13; 105(11). PMID: 18334649    Free PMC article.
t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in Her2/ErbB2 mice through activation of both proliferative and survival pathways.
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Carcinogenesis, 2008 Mar 15; 29(5). PMID: 18339686    Free PMC article.
Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1.
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Cancer Lett, 2008 Mar 22; 265(2). PMID: 18355957    Free PMC article.
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells.
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Cancer Res, 2008 Apr 03; 68(7). PMID: 18381409    Free PMC article.
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Oncogene, 2008 Apr 15; 27(34). PMID: 18408761    Free PMC article.
Highly Cited.
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Invest Ophthalmol Vis Sci, 2008 Apr 19; 49(8). PMID: 18421078    Free PMC article.
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J Mammary Gland Biol Neoplasia, 2008 Apr 22; 13(2). PMID: 18425425    Free PMC article.
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J Mammary Gland Biol Neoplasia, 2008 May 06; 13(2). PMID: 18454307
Review of cetuximab in the treatment of squamous cell carcinoma of the head and neck.
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EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer.
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J Clin Oncol, 2008 May 14; 26(19). PMID: 18474878    Free PMC article.
Highly Cited.
Structural basis for EGFR ligand sequestration by Argos.
Daryl E Klein, Steven E Stayrook, +2 authors, Mark A Lemmon.
Nature, 2008 May 27; 453(7199). PMID: 18500331    Free PMC article.
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Mol Pharmacol, 2008 Jun 12; 74(3). PMID: 18544666    Free PMC article.
Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.
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J Biol Chem, 2008 Jun 19; 283(35). PMID: 18559346    Free PMC article.
Affibody molecules for in vivo characterization of HER2-positive tumors by near-infrared imaging.
Sang Bong Lee, Moinuddin Hassan, +5 authors, Jacek Capala.
Clin Cancer Res, 2008 Jun 19; 14(12). PMID: 18559604    Free PMC article.
Recent progress in tumor pH targeting nanotechnology.
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Highly Cited. Review.
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Highly Cited. Review.
Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
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Am J Pathol, 2008 Jun 28; 173(1). PMID: 18583324    Free PMC article.
Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
Wenrong Li, Fang Li, +3 authors, Chuan-Yuan Li.
Cancer Res, 2008 Jul 03; 68(13). PMID: 18593895    Free PMC article.
Quercetin-induced ubiquitination and down-regulation of Her-2/neu.
Jae-Hoon Jeong, Jee Young An, +2 authors, Yong J Lee.
J Cell Biochem, 2008 Jul 26; 105(2). PMID: 18655187    Free PMC article.
Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain.
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J Natl Cancer Inst, 2008 Jul 31; 100(15). PMID: 18664652    Free PMC article.
Highly Cited.
Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs.
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Br J Cancer, 2008 Jul 31; 99(3). PMID: 18665191    Free PMC article.
Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2.
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J Virol, 2008 Aug 08; 82(20). PMID: 18684832    Free PMC article.
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Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type.
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Mol Cell Proteomics, 2008 Aug 09; 7(10). PMID: 18687633    Free PMC article.
Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors.
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Cancer, 2008 Aug 16; 113(6). PMID: 18704985    Free PMC article.
Brk is coamplified with ErbB2 to promote proliferation in breast cancer.
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Proc Natl Acad Sci U S A, 2008 Aug 23; 105(34). PMID: 18719096    Free PMC article.
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Highly Cited.
Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes.
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FASEB J, 2008 Sep 02; 22(12). PMID: 18757500    Free PMC article.
The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology.
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Exp Cell Res, 2008 Sep 02; 315(4). PMID: 18761338    Free PMC article.
Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs.
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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
Elisa Ciraolo, Manuela Iezzi, +20 authors, Emilio Hirsch.
Sci Signal, 2008 Sep 11; 1(36). PMID: 18780892    Free PMC article.
Highly Cited.
Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer.
S Senapati, P Chaturvedi, +5 authors, S K Batra.
Br J Cancer, 2008 Sep 11; 99(6). PMID: 18781152    Free PMC article.
Pharmacokinetic-directed dosing of vandetanib and docetaxel in a mouse model of human squamous cell carcinoma.
Erica L Bradshaw-Pierce, Courtney A Steinhauer, David Raben, Daniel L Gustafson.
Mol Cancer Ther, 2008 Sep 16; 7(9). PMID: 18790781    Free PMC article.
Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer.
Tim J Kruser, Eric A Armstrong, +5 authors, Paul M Harari.
Int J Radiat Oncol Biol Phys, 2008 Sep 17; 72(2). PMID: 18793955    Free PMC article.
Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response.
John Stagg, Janelle Sharkey, +5 authors, Mark J Smyth.
Proc Natl Acad Sci U S A, 2008 Oct 08; 105(42). PMID: 18838682    Free PMC article.
Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro.
M K Robinson, K M Hodge, +8 authors, G P Adams.
Br J Cancer, 2008 Oct 09; 99(9). PMID: 18841159    Free PMC article.
Phosphoproteomics: unraveling the signaling web.
Paul H Huang, Forest M White.
Mol Cell, 2008 Oct 17; 31(6). PMID: 18922462    Free PMC article.
Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers.
Kimio Yonesaka, Kreshnik Zejnullahu, +6 authors, Pasi A Jänne.
Clin Cancer Res, 2008 Nov 05; 14(21). PMID: 18980991    Free PMC article.
Interaction of antibodies with ErbB receptor extracellular regions.
Karl R Schmitz, Kathryn M Ferguson.
Exp Cell Res, 2008 Nov 11; 315(4). PMID: 18992239    Free PMC article.
Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma.
N Zeng, L Liu, +3 authors, V P Collins.
Neuropathol Appl Neurobiol, 2008 Nov 20; 35(4). PMID: 19017278    Free PMC article.
Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo.
Daniela Meco, Tiziana Servidei, +5 authors, Riccardo Riccardi.
Neuro Oncol, 2008 Nov 27; 11(3). PMID: 19033425    Free PMC article.
Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer.
Quanri Jin, Francisco J Esteva.
J Mammary Gland Biol Neoplasia, 2008 Nov 27; 13(4). PMID: 19034632
Radiotherapy for the management of locally advanced squamous cell carcinoma of the head and neck.
C Ko, D Citrin.
Oral Dis, 2008 Nov 28; 15(2). PMID: 19036056    Free PMC article.
The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation.
Shu-Mang Feng, Rebecca S Muraoka-Cook, +5 authors, H Shelton Earp.
Mol Cell Biol, 2008 Dec 03; 29(3). PMID: 19047365    Free PMC article.
Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients.
M I Galleges Ruiz, K Floor, +8 authors, G Giaccone.
Br J Cancer, 2008 Dec 04; 100(1). PMID: 19050706    Free PMC article.
The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population.
Uk Hyun Jo, Sle Gi Lo Han, +5 authors, Yeul Hong Kim.
BMC Cancer, 2008 Dec 06; 8. PMID: 19055823    Free PMC article.
An update on the biology of cancer stem cells in breast cancer.
José María García Bueno, Alberto Ocaña, +6 authors, Carmen Ramírez-Castillejo.
Clin Transl Oncol, 2008 Dec 11; 10(12). PMID: 19068449
Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma.
Alphonse-E Sirica.
World J Gastroenterol, 2008 Dec 17; 14(46). PMID: 19084911    Free PMC article.
tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO).
Javier A Menendez, Alejandro Vazquez-Martin, +4 authors, Antonio Segura-Carretero.
BMC Cancer, 2008 Dec 20; 8. PMID: 19094209    Free PMC article.
Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops.
Adi F Gazdar, John D Minna.
Cancer Prev Res (Phila), 2009 Jan 14; 1(3). PMID: 19138950    Free PMC article.
Recent advances of novel targeted therapy in non-small cell lung cancer.
Jed A Katzel, Michael P Fanucchi, Zujun Li.
J Hematol Oncol, 2009 Jan 23; 2. PMID: 19159467    Free PMC article.
Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.
Harald Schnidar, Markus Eberl, +8 authors, Fritz Aberger.
Cancer Res, 2009 Feb 05; 69(4). PMID: 19190345    Free PMC article.
Highly Cited.
Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: relevance of receptor endocytosis.
Tsipi Ben-Kasus, Bilha Schechter, +2 authors, Michael Sela.
Proc Natl Acad Sci U S A, 2009 Feb 17; 106(9). PMID: 19218427    Free PMC article.
High frequency of common DNA copy number abnormalities detected by bacterial artificial chromosome array comparative genomic hybridization in 24 breast cancer cell lines.
Soichiro Saito, Keiko Morita, Takashi Hirano.
Hum Cell, 2009 Feb 19; 22(1). PMID: 19222606
Mechanisms of tumor resistance to EGFR-targeted therapies.
Elizabeth A Hopper-Borge, Rochelle E Nasto, +3 authors, Igor Astsaturov.
Expert Opin Ther Targets, 2009 Feb 25; 13(3). PMID: 19236156    Free PMC article.
Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors.
Thomas Frogne, Anne-Vibeke Laenkholm, +2 authors, Anne E Lykkesfeldt.
Breast Cancer Res, 2009 Feb 26; 11(1). PMID: 19239686    Free PMC article.
Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells.
Kyoung-Ok Hong, Ji-Hong Kim, +4 authors, Seong-Doo Hong.
J Exp Clin Cancer Res, 2009 Feb 27; 28. PMID: 19243631    Free PMC article.
EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort.
Marileila Varella-Garcia, Tetsuya Mitsudomi, +8 authors, Fred R Hirsch.
J Thorac Oncol, 2009 Feb 28; 4(3). PMID: 19247083    Free PMC article.
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.
Christine A Pratilas, Barry S Taylor, +4 authors, Neal Rosen.
Proc Natl Acad Sci U S A, 2009 Mar 03; 106(11). PMID: 19251651    Free PMC article.
Highly Cited.
Stemming resistance to HER-2 targeted therapy.
Philippe L Bedard, Fatima Cardoso, Martine J Piccart-Gebhart.
J Mammary Gland Biol Neoplasia, 2009 Mar 05; 14(1). PMID: 19259796
The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside.
Hisataka Sabe, Shigeru Hashimoto, +2 authors, Eiji Ogawa.
Cell Adh Migr, 2009 Mar 06; 2(2). PMID: 19262097    Free PMC article.
Principles of cancer therapy: oncogene and non-oncogene addiction.
Ji Luo, Nicole L Solimini, Stephen J Elledge.
Cell, 2009 Mar 10; 136(5). PMID: 19269363    Free PMC article.
Highly Cited.
Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.
Eric Haines, Parham Minoo, +10 authors, Suhad Ali.
Mol Cell Biol, 2009 Mar 11; 29(10). PMID: 19273609    Free PMC article.
Targeting receptor tyrosine kinases for chemoprevention by green tea catechin, EGCG.
Masahito Shimizu, Yohei Shirakami, Hisataka Moriwaki.
Int J Mol Sci, 2009 Mar 28; 9(6). PMID: 19325845    Free PMC article.
CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases.
Cynthia A Zahnow.
Expert Rev Mol Med, 2009 Apr 09; 11. PMID: 19351437    Free PMC article.
A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis.
Kim Pedersen, Pier-Davide Angelini, +10 authors, Joaquín Arribas.
Mol Cell Biol, 2009 Apr 15; 29(12). PMID: 19364815    Free PMC article.
Update in antiepidermal growth factor receptor therapy in the management of metastatic colorectal cancer.
Herbert H Loong, Brigette B Ma, Anthony T C Chan.
J Oncol, 2009 Apr 15; 2009. PMID: 19365583    Free PMC article.
EGF-receptor regulation of matrix metalloproteinases in epithelial ovarian carcinoma.
Laurie G Hudson, Natalie M Moss, M Sharon Stack.
Future Oncol, 2009 Apr 21; 5(3). PMID: 19374540    Free PMC article.
Reasons for response differences seen in the V15-32, INTEREST and IPASS trials.
Nagahiro Saijo, Masahiro Takeuchi, Hideo Kunitoh.
Nat Rev Clin Oncol, 2009 Apr 25; 6(5). PMID: 19390555
ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery.
Glauco Baiocchi, Ademar Lopes, +6 authors, Wilson T Nakagawa.
Int J Colorectal Dis, 2009 Apr 25; 24(9). PMID: 19390858
Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment.
John H Phan, Richard A Moffitt, +4 authors, May D Wang.
Trends Biotechnol, 2009 May 05; 27(6). PMID: 19409634    Free PMC article.
The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.
Hisataka Sabe, Shigeru Hashimoto, +6 authors, Yasuhito Onodera.
Traffic, 2009 May 07; 10(8). PMID: 19416474    Free PMC article.
The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.
Tyler Lahusen, Ralf T Henke, +2 authors, Anna T Riegel.
Breast Cancer Res Treat, 2009 May 07; 116(2). PMID: 19418218    Free PMC article.
Clinical Efficacy and Toxicity of Anti-EGFR Therapy in Common Cancers.
Amir Harandi, Aisha S Zaidi, Abigail M Stocker, Damian A Laber.
J Oncol, 2009 May 09; 2009. PMID: 19424511    Free PMC article.
Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target.
Juan Carlos Montero, Alberto Ocaña, +3 authors, Azucena Esparís-Ogando.
PLoS One, 2009 May 15; 4(5). PMID: 19440538    Free PMC article.
Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
Qinglong Li, Zhulin Yang.
J Exp Clin Cancer Res, 2009 May 19; 28. PMID: 19445727    Free PMC article.
The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies.
Jaclyn A Freudenberg, Qiang Wang, +3 authors, Mark I Greene.
Exp Mol Pathol, 2009 May 20; 87(1). PMID: 19450579    Free PMC article.
The potential role of pharmacogenomic and genomic in the adjuvant treatment of early stage non small cell lung cancer.
Clorinda Schettino, Maria A Bareschino, +3 authors, Cesare Gridelli.
Curr Genomics, 2009 May 20; 9(4). PMID: 19452042    Free PMC article.
Skin toxicities associated with epidermal growth factor receptor inhibitors.
Tianhong Li, Roman Perez-Soler.
Target Oncol, 2009 May 20; 4(2). PMID: 19452131
Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells.
Laura Menotti, Giordano Nicoletti, +6 authors, Gabriella Campadelli-Fiume.
Proc Natl Acad Sci U S A, 2009 May 22; 106(22). PMID: 19458262    Free PMC article.
An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse.
Sylvia E Le Dévédec, Wies van Roosmalen, +4 authors, Bob van de Water.
Clin Exp Metastasis, 2009 May 26; 26(7). PMID: 19466569    Free PMC article.
Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway.
Y Liu, R Pixley, +4 authors, R W Colman.
Oncogene, 2009 Jun 02; 28(30). PMID: 19483730    Free PMC article.
Investigational agents in the management of non-small cell lung cancer.
Nathan A Pennell, Tarek Mekhail.
Curr Oncol Rep, 2009 Jun 11; 11(4). PMID: 19508832
GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.
Kyoko Tashiro, Takumi Tsunematsu, +5 authors, Hiroaki Konishi.
J Biol Chem, 2009 Jun 11; 284(30). PMID: 19509291    Free PMC article.
In vitro enzymatic characterization of near full length EGFR in activated and inhibited states.
Chen Qiu, Mary K Tarrant, +5 authors, Daniel J Leahy.
Biochemistry, 2009 Jun 13; 48(28). PMID: 19518076    Free PMC article.
Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2.
Hwang-Phill Kim, Young-Kwang Yoon, +8 authors, Tae-You Kim.
PLoS One, 2009 Jun 17; 4(6). PMID: 19529774    Free PMC article.
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.
José Baselga, Sandra M Swain.
Nat Rev Cancer, 2009 Jun 19; 9(7). PMID: 19536107
Highly Cited. Review.
Structure-function analysis of nucleolin and ErbB receptors interactions.
Keren Farin, Ayelet Di Segni, Adam Mor, Ronit Pinkas-Kramarski.
PLoS One, 2009 Jul 07; 4(7). PMID: 19578540    Free PMC article.
Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells.
Yuhong Du, Zijian Li, +6 authors, Haian Fu.
J Recept Signal Transduct Res, 2009 Jul 17; 29(3-4). PMID: 19604037    Free PMC article.
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.
Xin Lu, Qiongqing Wang, +5 authors, Yibin Kang.
Genes Dev, 2009 Jul 18; 23(16). PMID: 19608765    Free PMC article.
Highly Cited.
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
R Novosyadlyy, A Vijayakumar, +3 authors, D LeRoith.
Oncogene, 2009 Jul 21; 28(39). PMID: 19617901    Free PMC article.
Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction.
Michelle N Costa, Krishnan Radhakrishnan, +2 authors, Jeremy S Edwards.
PLoS One, 2009 Jul 25; 4(7). PMID: 19626123    Free PMC article.
Quantitative prediction of fold resistance for inhibitors of EGFR.
Trent E Balius, Robert C Rizzo.
Biochemistry, 2009 Jul 25; 48(35). PMID: 19627157    Free PMC article.
Anti-EGFR-Targeted Therapy for Esophageal and Gastric Cancers: An Evolving Concept.
Tomislav Dragovich, Christopher Campen.
J Oncol, 2009 Jul 29; 2009. PMID: 19636422    Free PMC article.
Targeting signal transducer and activator of transcription signaling pathway in leukemias.
Mustafa Benekli, Heinz Baumann, Meir Wetzler.
J Clin Oncol, 2009 Aug 12; 27(26). PMID: 19667270    Free PMC article.
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium.
Daekee Lee, Ming Yu, +6 authors, David W Threadgill.
J Clin Invest, 2009 Aug 20; 119(9). PMID: 19690388    Free PMC article.
Design, synthesis, and docking studies of peptidomimetics based on HER2-herceptin binding site with potential antiproliferative activity against breast cancer cell lines.
Seetharama Satyanarayanajois, Stephanie Villalba, Liu Jianchao, Go Mei Lin.
Chem Biol Drug Des, 2009 Aug 26; 74(3). PMID: 19703026    Free PMC article.
Clinical activities of the epidermal growth factor receptor family inhibitors in breast cancer.
Elizabeth S Henson, James B Johnston, Marek Los, Spencer B Gibson.
Biologics, 2007 Sep 01; 1(3). PMID: 19707333    Free PMC article.
ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor.
Diego Alvarado, Daryl E Klein, Mark A Lemmon.
Nature, 2009 Sep 01; 461(7261). PMID: 19718021    Free PMC article.
Growth factors and corneal epithelial wound healing.
Fu-Shin X Yu, Jia Yin, Keping Xu, Jenny Huang.
Brain Res Bull, 2009 Sep 08; 81(2-3). PMID: 19733636    Free PMC article.
Activated epidermal growth factor receptor in ovarian cancer.
Laurie G Hudson, Reema Zeineldin, Melina Silberberg, M Sharon Stack.
Cancer Treat Res, 2009 Sep 19; 149. PMID: 19763438    Free PMC article.
Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization.
Christoph Ausch, Veronika Buxhofer-Ausch, +6 authors, Gernot Kriegshäuser.
J Mol Diagn, 2009 Oct 03; 11(6). PMID: 19797612    Free PMC article.
PET and SPECT Imaging of Tumor Biology: New Approaches towards Oncology Drug Discovery and Development.
Marcian E Van Dort, Alnawaz Rehemtulla, Brian D Ross.
Curr Comput Aided Drug Des, 2008 Jan 01; 4(1). PMID: 19809593    Free PMC article.
A phase I and pharmacokinetic study of oral lapatinib administered once or twice daily in patients with solid malignancies.
Howard A Burris, Charles W Taylor, +8 authors, George Wilding.
Clin Cancer Res, 2009 Oct 15; 15(21). PMID: 19825948    Free PMC article.
Emerging roles of E2Fs in cancer: an exit from cell cycle control.
Hui-Zi Chen, Shih-Yin Tsai, Gustavo Leone.
Nat Rev Cancer, 2009 Oct 24; 9(11). PMID: 19851314    Free PMC article.
Highly Cited. Review.
Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors.
Shao-Chun Wang, Mien-Chie Hung.
Clin Cancer Res, 2009 Oct 29; 15(21). PMID: 19861462    Free PMC article.
Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance.
Cynthie Wong, Shiuan Chen.
Cancer Res, 2009 Oct 29; 69(22). PMID: 19861537    Free PMC article.
Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts.
C Larbouret, B Robert, +7 authors, D Azria.
Ann Oncol, 2009 Nov 06; 21(1). PMID: 19889608    Free PMC article.
Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines.
Grégory Nolens, Jean-Christophe Pignon, +4 authors, Rosita Winkler.
Breast Cancer Res, 2009 Nov 13; 11(6). PMID: 19906305    Free PMC article.
Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer.
Chitta Ranjan Patra, Resham Bhattacharya, Debabrata Mukhopadhyay, Priyabrata Mukherjee.
Adv Drug Deliv Rev, 2009 Nov 17; 62(3). PMID: 19914317    Free PMC article.
Biomarkers and anti-EGFR therapies for KRAS wild-type metastatic colorectal cancer.
Jose A García-Sáenz, Javier Sastre, Eduardo Díaz-Rubio García.
Clin Transl Oncol, 2009 Nov 18; 11(11). PMID: 19917537
A novel pharmacodynamic approach to assess and predict tumor response to the epidermal growth factor receptor inhibitor gefitinib in patients with esophageal cancer.
Soner Altiok, Heather Mezzadra, +6 authors, Michael K Gibson.
Int J Oncol, 2009 Dec 04; 36(1). PMID: 19956829    Free PMC article.
Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling.
Hyun Kyoung Lee, In Ae Seo, +3 authors, Hwan Tae Park.
Korean J Physiol Pharmacol, 2008 Oct 01; 12(5). PMID: 19967068    Free PMC article.
[Molecular diagnostics in lung carcinoma for therapy stratification].
L C Heukamp, R Büttner.
Pathologe, 2009 Dec 10; 31(1). PMID: 19997736
Resistance to Trastuzumab in Breast Cancer.
Paula R Pohlmann, Ingrid A Mayer, Ray Mernaugh.
Clin Cancer Res, 2009 Dec 17; 15(24). PMID: 20008848    Free PMC article.
Highly Cited.
Sustained activity of the EGF receptor is an absolute requisite for LH-induced oocyte maturation and cumulus expansion.
Yitzhak Reizel, Judith Elbaz, Nava Dekel.
Mol Endocrinol, 2009 Dec 17; 24(2). PMID: 20009084    Free PMC article.
Epidermal growth factor signalling and bone metastasis.
X Lu, Y Kang.
Br J Cancer, 2009 Dec 17; 102(3). PMID: 20010942    Free PMC article.
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.
Guanglei Zhuang, Dana M Brantley-Sieders, +7 authors, Jin Chen.
Cancer Res, 2009 Dec 24; 70(1). PMID: 20028874    Free PMC article.
Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin.
Melarkode S Ramakrishnan, Anand Eswaraiah, +4 authors, A S Arvind.
MAbs, 2010 Jan 05; 1(1). PMID: 20046573    Free PMC article.
Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells.
Seok Joon Kwon, Moon Il Kim, +5 authors, Jonathan S Dordick.
Chembiochem, 2010 Jan 09; 11(4). PMID: 20058253    Free PMC article.
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells.
Ann M Ratchford, Olga J Baker, +5 authors, Gary A Weisman.
J Biol Chem, 2010 Jan 13; 285(10). PMID: 20064929    Free PMC article.
Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.
Jason P Holland, Eloisi Caldas-Lopes, +5 authors, Jason S Lewis.
PLoS One, 2010 Jan 30; 5(1). PMID: 20111600    Free PMC article.
Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy.
Adi F Gazdar.
Cancer Metastasis Rev, 2010 Feb 04; 29(1). PMID: 20127143    Free PMC article.
PIKing the right isoform: the emergent role of the p110beta subunit in breast cancer.
Silvia Carvalho, Fernanda Milanezi, +2 authors, Fernando Schmitt.
Virchows Arch, 2010 Feb 05; 456(3). PMID: 20130907
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.
Jay P Reddy, Sirisha Peddibhotla, +7 authors, Yi Li.
Proc Natl Acad Sci U S A, 2010 Feb 06; 107(8). PMID: 20133707    Free PMC article.
An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo.
Craig Cherrin, Kathleen Haskell, +16 authors, Hans E Huber.
Cancer Biol Ther, 2010 Feb 09; 9(7). PMID: 20139722    Free PMC article.
A proposed EGFR inhibitor dermatologic adverse event-specific grading scale from the MASCC skin toxicity study group.
Mario E Lacouture, Michael L Maitland, +17 authors, Andy Trotti.
Support Care Cancer, 2010 Feb 11; 18(4). PMID: 20145956
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.
Christophe Frémin, Sylvain Meloche.
J Hematol Oncol, 2010 Feb 13; 3. PMID: 20149254    Free PMC article.
Oncologist's/haematologist's view on the roles of pathologists for molecular targeted cancer therapy.
Ulrich Keller, Nikolas von Bubnoff, Christian Peschel, Justus Duyster.
J Cell Mol Med, 2010 Feb 18; 14(4). PMID: 20158573    Free PMC article.
The constitutive activity of epidermal growth factor receptor vIII leads to activation and differential trafficking of wild-type epidermal growth factor receptor and erbB2.
Reema Zeineldin, Yan Ning, Laurie G Hudson.
J Histochem Cytochem, 2010 Feb 18; 58(6). PMID: 20159766    Free PMC article.
Advances and Perspectives in the Molecular Diagnosis of Head and Neck Cancer.
Wojciech K Mydlarz, Patrick T Hennessey, Joseph A Califano.
Expert Opin Med Diagn, 2010 Feb 18; 4(1). PMID: 20161611    Free PMC article.
Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.
Pinglong Xu, Rik Derynck.
Mol Cell, 2010 Mar 02; 37(4). PMID: 20188673    Free PMC article.
Highly Cited.
Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists.
Xiuwei H Yang, Ludmila M Flores, +4 authors, Martin E Hemler.
Cancer Res, 2010 Mar 04; 70(6). PMID: 20197472    Free PMC article.
Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines.
Ming-Chieh Shun, Weiping Yu, +2 authors, Kimberly Kline.
J Oncol, 2010 Mar 13; 2010. PMID: 20224651    Free PMC article.
Andrographolide regulates epidermal growth factor receptor and transferrin receptor trafficking in epidermoid carcinoma (A-431) cells.
Y Tan, K H Chiow, D Huang, S H Wong.
Br J Pharmacol, 2010 Mar 18; 159(7). PMID: 20233216    Free PMC article.
EGFR(S) inhibitors in the treatment of gastro-intestinal cancers: what's new?
Shailender Singh Kanwar, Jyoti Nautiyal, Adhip P N Majumdar.
Curr Drug Targets, 2010 Mar 20; 11(6). PMID: 20298154    Free PMC article.
Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.
Hong Jin Lee, Jae-Young So, +5 authors, Nanjoo Suh.
J Steroid Biochem Mol Biol, 2010 Mar 23; 121(1-2). PMID: 20304052    Free PMC article.
Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells.
Taichang Yuan, Yongping Wang, Zhizhuang J Zhao, Haihua Gu.
J Biol Chem, 2010 Mar 26; 285(20). PMID: 20335174    Free PMC article.
Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells.
S Bafna, S Kaur, S K Batra.
Oncogene, 2010 Mar 30; 29(20). PMID: 20348949    Free PMC article.
Highly Cited. Review.
Matrix metalloproteinases: regulators of the tumor microenvironment.
Kai Kessenbrock, Vicki Plaks, Zena Werb.
Cell, 2010 Apr 08; 141(1). PMID: 20371345    Free PMC article.
Highly Cited. Review.
The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells.
Yan Lu, Hua Zhou, +2 authors, Anne W Hamburger.
Breast Cancer Res Treat, 2010 Apr 10; 126(1). PMID: 20379846    Free PMC article.
Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor.
Maurizio Scaltriti, Sarat Chandarlapaty, +15 authors, José Baselga.
Clin Cancer Res, 2010 Apr 22; 16(9). PMID: 20406840    Free PMC article.
Fatty acid-binding protein 5 and PPARbeta/delta are critical mediators of epidermal growth factor receptor-induced carcinoma cell growth.
Padmamalini Kannan-Thulasiraman, Darcie D Seachrist, +2 authors, Noa Noy.
J Biol Chem, 2010 Apr 29; 285(25). PMID: 20424164    Free PMC article.
Roles for growth factors in cancer progression.
Esther Witsch, Michael Sela, Yosef Yarden.
Physiology (Bethesda), 2010 May 01; 25(2). PMID: 20430953    Free PMC article.
Highly Cited. Review.
Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity.
Goldi A Kozloski, Coralie A Carothers Carraway, Kermit L Carraway.
J Cell Physiol, 2010 May 01; 224(3). PMID: 20432461    Free PMC article.
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Nancy Van Damme, Philippe Deron, +8 authors, Marc Peeters.
BMC Cancer, 2010 May 13; 10. PMID: 20459770    Free PMC article.
Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.
Luisa Paris, Serena Cecchetti, +7 authors, Franca Podo.
Breast Cancer Res, 2010 May 14; 12(3). PMID: 20462431    Free PMC article.
Design and synthesis of novel Gefitinib analogues with improved anti-tumor activity.
Xiaoqing Wu, Mingdong Li, +5 authors, Liang Xu.
Bioorg Med Chem, 2010 May 15; 18(11). PMID: 20466555    Free PMC article.
Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.
Y-N Wang, H Yamaguchi, J-M Hsu, M-C Hung.
Oncogene, 2010 May 18; 29(28). PMID: 20473332    Free PMC article.
Preparation, biological evaluation, and pharmacokinetics of the human anti-HER1 monoclonal antibody panitumumab labeled with 86Y for quantitative PET of carcinoma.
Tapan K Nayak, Kayhan Garmestani, +2 authors, Martin W Brechbiel.
J Nucl Med, 2010 May 21; 51(6). PMID: 20484421    Free PMC article.
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
Tsai-Der Chuang, Siu-Ju Chen, +5 authors, Ming-Fong Lin.
J Biol Chem, 2010 May 26; 285(31). PMID: 20498373    Free PMC article.
Imatinib and docetaxel in combination can effectively inhibit glioma invasion in an in vitro 3D invasion assay.
Paula Kinsella, Martin Clynes, Verena Amberger-Murphy.
J Neurooncol, 2010 Jun 01; 101(2). PMID: 20512610
Cancer-associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs.
Sheldon R Mink, Surabhi Vashistha, +3 authors, Anjali Jain.
Mol Cancer Res, 2010 Jun 10; 8(6). PMID: 20530582    Free PMC article.
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Thomas Mund, Hugh R B Pelham.
Proc Natl Acad Sci U S A, 2010 Jun 11; 107(25). PMID: 20534535    Free PMC article.
Triple-negative breast cancer: present challenges and new perspectives.
Franca Podo, Lutgarde M C Buydens, +16 authors, FEMME Consortium.
Mol Oncol, 2010 Jun 12; 4(3). PMID: 20537966    Free PMC article.
Highly Cited. Review.
Understanding resistance to EGFR inhibitors-impact on future treatment strategies.
Deric L Wheeler, Emily F Dunn, Paul M Harari.
Nat Rev Clin Oncol, 2010 Jun 17; 7(9). PMID: 20551942    Free PMC article.
Highly Cited. Review.
Targeted therapy in non-small-cell lung cancer--is it becoming a reality?
Filip Janku, David J Stewart, Razelle Kurzrock.
Nat Rev Clin Oncol, 2010 Jun 17; 7(7). PMID: 20551945
Mammary gland growth factors: roles in normal development and in cancer.
Nancy E Hynes, Christine J Watson.
Cold Spring Harb Perspect Biol, 2010 Jun 18; 2(8). PMID: 20554705    Free PMC article.
KRAS, BRAF, EGFR and HER2 gene status in a Spanish population of colorectal cancer.
Marta Herreros-Villanueva, Maximiliano Rodrigo, +4 authors, Maria Jesus Coma del Corral.
Mol Biol Rep, 2010 Jun 22; 38(2). PMID: 20563851
Epidermal growth factor receptor targeted therapy in stages III and IV head and neck cancer.
C Cripps, E Winquist, +3 authors, Head and Neck Cancer Disease Site Group.
Curr Oncol, 2010 Jun 23; 17(3). PMID: 20567625    Free PMC article.
Classical and Novel Prognostic Markers for Breast Cancer and their Clinical Significance.
Pankaj Taneja, Dejan Maglic, +4 authors, Kazushi Inoue.
Clin Med Insights Oncol, 2010 Jun 23; 4. PMID: 20567632    Free PMC article.
PIK3CA mutations in KRAS and BRAF wild type colorectal cancer patients. A study of Spanish population.
Marta Herreros-Villanueva, Noemí Gomez-Manero, +2 authors, Maria Jesús Coma del Corral.
Mol Biol Rep, 2010 Jun 24; 38(2). PMID: 20571907
EGFR inhibitors in non-small cell lung cancer (NSCLC): the emerging role of the dual irreversible EGFR/HER2 inhibitor BIBW 2992.
James F Spicer, Sarah M Rudman.
Target Oncol, 2010 Jun 25; 5(4). PMID: 20574858
Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling.
Amber B Pfister, Robert C Wood, +2 authors, Victoria P Ramsauer.
J Cell Biochem, 2010 Jul 01; 111(3). PMID: 20589763    Free PMC article.
Targeting inflammatory pathways for tumor radiosensitization.
Amit Deorukhkar, Sunil Krishnan.
Biochem Pharmacol, 2010 Jul 06; 80(12). PMID: 20599771    Free PMC article.
Rational use of cetuximab in the treatment of advanced non-small cell lung cancer.
Charu Aggarwal, Hossein Borghaei.
Onco Targets Ther, 2009 Jan 01; 2. PMID: 20616912    Free PMC article.
Quantitative analysis of Her2 receptor expression in vivo by near-infrared optical imaging.
Victor Chernomordik, Moinuddin Hassan, +3 authors, Jacek Capala.
Mol Imaging, 2010 Jul 21; 9(4). PMID: 20643022    Free PMC article.
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.
María M Caffarel, Clara Andradas, +9 authors, Cristina Sánchez.
Mol Cancer, 2010 Jul 24; 9. PMID: 20649976    Free PMC article.
[Analysis of signalling pathways in formalin-fixed breast cancer tissues].
D Berg, H Bronger, +2 authors, K-F Becker.
Pathologe, 2010 Jul 24; 31 Suppl 2. PMID: 20652812
Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.
Steven M Mooney, Apollina Goel, +2 authors, Ralf Janknecht.
J Biol Chem, 2010 Jul 29; 285(40). PMID: 20663877    Free PMC article.
[A review of epidermal growth factor receptor/HER2 inhibitors in the treatment of patients with non-small-cell lung cancer].
Ramaswamy Govindan.
Zhongguo Fei Ai Za Zhi, 2010 Aug 04; 13(4). PMID: 20677566    Free PMC article.
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.
Nao Hiramoto-Yamaki, Shingo Takeuchi, +4 authors, Hironori Katoh.
J Cell Biol, 2010 Aug 04; 190(3). PMID: 20679435    Free PMC article.
VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.
Isabel F Fernández, Sandra Blanco, José Lozano, Pedro A Lazo.
Mol Cell Biol, 2010 Aug 04; 30(19). PMID: 20679487    Free PMC article.
Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study.
Maryam Fouladi, Clinton F Stewart, +7 authors, Richard J Gilbertson.
J Clin Oncol, 2010 Aug 18; 28(27). PMID: 20713864    Free PMC article.
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.
Murielle Mimeault, Surinder K Batra.
Pharmacol Rev, 2010 Aug 19; 62(3). PMID: 20716670    Free PMC article.
EGFR signaling in breast cancer: bad to the bone.
John Foley, Nicole K Nickerson, +4 authors, David J Riese.
Semin Cell Dev Biol, 2010 Sep 04; 21(9). PMID: 20813200    Free PMC article.
Clinical Experience with Lapatinib in Patients with ErbB2-Overexpressing Metastatic Breast Cancer.
Nadia Harbeck, Volker Heinemann, Sibylle Loibl, Michael Untch.
Breast Care (Basel), 2008 Jan 01; 3(s1). PMID: 20824002    Free PMC article.
ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis.
Craig I Campbell, James J Petrik, Roger A Moorehead.
Mol Cancer, 2010 Sep 10; 9. PMID: 20825649    Free PMC article.
Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review.
Carolin M Grimminger, Peter V Danenberg.
Eur Arch Otorhinolaryngol, 2010 Sep 10; 268(1). PMID: 20827554
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.
Chafen Lu, Li-Zhi Mi, +4 authors, Timothy A Springer.
Mol Cell Biol, 2010 Sep 15; 30(22). PMID: 20837704    Free PMC article.
Targeted Therapy in Metastatic Breast Cancer: The HER2/neu Oncogene.
Nadia Harbeck, Mark D Pegram, Josef Rüschoff, Volker Möbus.
Breast Care (Basel), 2010 Sep 18; 5(s1). PMID: 20847829    Free PMC article.
Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer.
M F E Godinho, A M Sieuwerts, +4 authors, T van Agthoven.
Br J Cancer, 2010 Sep 23; 103(8). PMID: 20859285    Free PMC article.
Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies.
Daniel J Toft, Vincent L Cryns.
Mol Endocrinol, 2010 Sep 24; 25(2). PMID: 20861225    Free PMC article.
E3 ubiquitin ligases in ErbB receptor quantity control.
Kermit L Carraway.
Semin Cell Dev Biol, 2010 Sep 28; 21(9). PMID: 20868762    Free PMC article.
Dual Inhibitor AEE788 Reduces Tumor Growth in Preclinical Models of Medulloblastoma.
Daniela Meco, Tiziana Servidei, +4 authors, Riccardo Riccardi.
Transl Oncol, 2010 Oct 05; 3(5). PMID: 20885895    Free PMC article.
A conformationally constrained peptidomimetic binds to the extracellular region of HER2 protein.
Sashikanth Banappagari, Sharon Ronald, Seetharama D Satyanarayanajois.
J Biomol Struct Dyn, 2010 Oct 06; 28(3). PMID: 20919746    Free PMC article.
Pharmacokinetic and pharmacodynamic perspectives on the clinical drug development of panitumumab.
Bing-Bing Yang, Peggy Lum, +4 authors, Juan José Pérez Ruixo.
Clin Pharmacokinet, 2010 Oct 07; 49(11). PMID: 20923247
PTP1B suppresses prolactin activation of Stat5 in breast cancer cells.
Kevin J Johnson, Amy R Peck, +6 authors, Hallgeir Rui.
Am J Pathol, 2010 Oct 19; 177(6). PMID: 20952588    Free PMC article.
ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells.
Alexandra R Grassian, Zachary T Schafer, Joan S Brugge.
J Biol Chem, 2010 Oct 20; 286(1). PMID: 20956544    Free PMC article.
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer.
William Pao, Juliann Chmielecki.
Nat Rev Cancer, 2010 Oct 23; 10(11). PMID: 20966921    Free PMC article.
Highly Cited. Review.
Matriptase is involved in ErbB-2-induced prostate cancer cell invasion.
Shang-Ru Wu, Tai-Shan Cheng, +8 authors, Ming-Shyue Lee.
Am J Pathol, 2010 Oct 26; 177(6). PMID: 20971737    Free PMC article.
Reverse phase protein microarrays advance to use in clinical trials.
Claudius Mueller, Lance A Liotta, Virginia Espina.
Mol Oncol, 2010 Oct 27; 4(6). PMID: 20974554    Free PMC article.
Increasing CD44+/CD24(-) tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis.
Kai-Hung Wang, An-Pei Kao, +5 authors, Eing-Mei Tsai.
Mol Cancer, 2010 Nov 04; 9. PMID: 21044318    Free PMC article.
Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer.
Masaaki Oyama, Takeshi Nagashima, +10 authors, Mariko Okada-Hatakeyama.
J Biol Chem, 2010 Nov 04; 286(1). PMID: 21044952    Free PMC article.
pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation.
Ming An, Dayanjali Wijesinghe, +2 authors, Donald M Engelman.
Proc Natl Acad Sci U S A, 2010 Nov 05; 107(47). PMID: 21048084    Free PMC article.
Critical roles of DMP1 in human epidermal growth factor receptor 2/neu-Arf-p53 signaling and breast cancer development.
Pankaj Taneja, Dejan Maglic, +5 authors, Kazushi Inoue.
Cancer Res, 2010 Nov 11; 70(22). PMID: 21062982    Free PMC article.
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
Lusine Aghajanova, Linda C Giudice.
Reprod Sci, 2010 Nov 11; 18(3). PMID: 21063030    Free PMC article.
Applications of molecular imaging.
Craig J Galbán, Stefanie Galbán, +4 authors, Brian D Ross.
Prog Mol Biol Transl Sci, 2010 Nov 16; 95. PMID: 21075334    Free PMC article.
Inorganic nanoparticles in cancer therapy.
Sanjib Bhattacharyya, Rachel A Kudgus, Resham Bhattacharya, Priyabrata Mukherjee.
Pharm Res, 2010 Nov 26; 28(2). PMID: 21104301    Free PMC article.
EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy.
Christian Freudlsperger, Jeffrey R Burnett, +3 authors, Carter Van Waes.
Expert Opin Ther Targets, 2010 Nov 30; 15(1). PMID: 21110697    Free PMC article.
Self-association of models of transmembrane domains of ErbB receptors in a lipid bilayer.
Anupam Prakash, Lorant Janosi, Manolis Doxastakis.
Biophys J, 2010 Nov 30; 99(11). PMID: 21112290    Free PMC article.
Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.
Gang Chen, Paritosh Ghosh, Dan L Longo.
Mol Cancer Res, 2010 Dec 07; 9(1). PMID: 21131601    Free PMC article.
The molecular biology of head and neck cancer.
C René Leemans, Boudewijn J M Braakhuis, Ruud H Brakenhoff.
Nat Rev Cancer, 2010 Dec 17; 11(1). PMID: 21160525
Highly Cited. Review.
Current approach in the treatment of hepatocellular carcinoma.
Luigi Rossi, Federica Zoratto, +4 authors, Silverio Tomao.
World J Gastrointest Oncol, 2010 Dec 17; 2(9). PMID: 21160806    Free PMC article.
EGFR-mutated lung cancer: a paradigm of molecular oncology.
Zhenfeng Zhang, Amy L Stiegler, +2 authors, Balazs Halmos.
Oncotarget, 2010 Dec 18; 1(7). PMID: 21165163    Free PMC article.
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
Maria Soledad Sosa, Cynthia Lopez-Haber, +10 authors, Marcelo G Kazanietz.
Mol Cell, 2010 Dec 22; 40(6). PMID: 21172654    Free PMC article.
Highly Cited.
Calmodulin binds HER2 and modulates HER2 signaling.
Colin D White, Zhigang Li, David B Sacks.
Biochim Biophys Acta, 2010 Dec 28; 1813(5). PMID: 21185879    Free PMC article.
Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations.
Jill Wykosky, Tim Fenton, Frank Furnari, Webster K Cavenee.
Chin J Cancer, 2011 Jan 05; 30(1). PMID: 21192840    Free PMC article.
Targeted therapies in cancer - challenges and chances offered by newly developed techniques for protein analysis in clinical tissues.
K Malinowsky, C Wolff, +2 authors, Kf Becker.
J Cancer, 2011 Jan 05; 2. PMID: 21197262    Free PMC article.
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
Sarat Chandarlapaty, Ayana Sawai, +6 authors, Neal Rosen.
Cancer Cell, 2011 Jan 11; 19(1). PMID: 21215704    Free PMC article.
Highly Cited.
Glutaminase: a hot spot for regulation of cancer cell metabolism?
Jon W Erickson, Richard A Cerione.
Oncotarget, 2011 Jan 15; 1(8). PMID: 21234284    Free PMC article.
Chemoprevention of hormone receptor-negative breast cancer: new approaches needed.
Iván P Uray, Powel H Brown.
Recent Results Cancer Res, 2011 Jan 22; 188. PMID: 21253797    Free PMC article.
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.
Jung-Mao Hsu, Chun-Te Chen, +12 authors, Mien-Chie Hung.
Nat Cell Biol, 2011 Jan 25; 13(2). PMID: 21258366    Free PMC article.
Association between EGF +61A/G polymorphism and gastric cancer in Caucasians.
Ana Paula Araújo, Bruno M Costa, +6 authors, Rui Medeiros.
World J Gastroenterol, 2011 Jan 29; 17(4). PMID: 21274378    Free PMC article.
Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evaluate the efficiency of targeted therapy using monoclonal antibodies.
Nadège Gaborit, Christel Larbouret, +9 authors, André Pèlegrin.
J Biol Chem, 2011 Feb 02; 286(13). PMID: 21282108    Free PMC article.
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.
Toni M Brand, Mari Iida, Deric L Wheeler.
Cancer Biol Ther, 2011 Feb 05; 11(9). PMID: 21293176    Free PMC article.
Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins.
Ali Mukherjee, Youssouf Badal, +6 authors, Stephen Williams.
PLoS One, 2011 Feb 08; 6(1). PMID: 21297994    Free PMC article.
[Molecular diagnostics of lung cancer for treatment stratification].
L C Heukamp, J Wolf, R Büttner.
Internist (Berl), 2011 Feb 08; 52(2). PMID: 21298249
Comparing the epidermal growth factor interaction with four different cell lines: intriguing effects imply strong dependency of cellular context.
Hanna Björkelund, Lars Gedda, Karl Andersson.
PLoS One, 2011 Feb 10; 6(1). PMID: 21304974    Free PMC article.
Combination treatment with HER-2 and VEGF peptide mimics induces potent anti-tumor and anti-angiogenic responses in vitro and in vivo.
Kevin C Foy, Zhenzhen Liu, +2 authors, Pravin T P Kaumaya.
J Biol Chem, 2011 Feb 18; 286(15). PMID: 21325276    Free PMC article.
Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.
Yoshimi Naruo, Takeshi Nagashima, +6 authors, Mariko Okada-Hatakeyama.
BMC Syst Biol, 2011 Feb 22; 5. PMID: 21333004    Free PMC article.
HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies.
Devika Gajria, Sarat Chandarlapaty.
Expert Rev Anticancer Ther, 2011 Feb 24; 11(2). PMID: 21342044    Free PMC article.
Highly Cited. Review.
Positron emission tomography imaging of cancer biology: current status and future prospects.
Kai Chen, Xiaoyuan Chen.
Semin Oncol, 2011 Mar 03; 38(1). PMID: 21362517    Free PMC article.
Expression of NRG1 and its receptors in human bladder cancer.
J A Forster, A B Paul, P Harnden, M A Knowles.
Br J Cancer, 2011 Mar 03; 104(7). PMID: 21364580    Free PMC article.
Strategies for overcoming resistance to EGFR family tyrosine kinase inhibitors.
Giuseppe Giaccone, Yisong Wang.
Cancer Treat Rev, 2011 Mar 04; 37(6). PMID: 21367530    Free PMC article.
EGFR Signaling in Colorectal Carcinoma.
Alyssa M Krasinskas.
Patholog Res Int, 2011 Mar 16; 2011. PMID: 21403829    Free PMC article.
Impact of KRAS Mutations on Management of Colorectal Carcinoma.
Kevin M Sullivan, Peter S Kozuch.
Patholog Res Int, 2011 Mar 26; 2011. PMID: 21437184    Free PMC article.
Personalizing therapy with targeted agents in non-small cell lung cancer.
Rodrigo Dienstmann, Pablo Martinez, Enriqueta Felip.
Oncotarget, 2011 Mar 30; 2(3). PMID: 21444946    Free PMC article.
Emerging strategies for the early detection and prevention of head and neck squamous cell cancer.
Santanu Dasgupta, Rupesh Dash, +2 authors, Paul B Fisher.
J Cell Physiol, 2011 Apr 06; 227(2). PMID: 21465466    Free PMC article.
Graphene-encapsulated nanoparticle-based biosensor for the selective detection of cancer biomarkers.
Sung Myung, Aniruddh Solanki, +3 authors, Ki-Bum Lee.
Adv Mater, 2011 Apr 07; 23(19). PMID: 21469221    Free PMC article.
Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.
Wei-Chien Huang, Yun-Ju Chen, +12 authors, Mien-Chie Hung.
J Biol Chem, 2011 Apr 14; 286(23). PMID: 21487020    Free PMC article.
Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma.
S John Weroha, Ann L Oberg, +7 authors, Paul Haluska.
Gynecol Oncol, 2011 Apr 26; 122(1). PMID: 21514634    Free PMC article.
Harnessing synthetic lethal interactions in anticancer drug discovery.
Denise A Chan, Amato J Giaccia.
Nat Rev Drug Discov, 2011 May 03; 10(5). PMID: 21532565    Free PMC article.
Highly Cited. Review.
Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells.
Hao-Chen Wang, Hsuan-Heng Yeh, +5 authors, Wu-Chou Su.
Mol Endocrinol, 2011 May 07; 25(7). PMID: 21546410    Free PMC article.
Generation and characterization of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies.
Esther J Witsch, Georg Mahlknecht, +4 authors, Michael Sela.
Int Immunol, 2011 May 24; 23(6). PMID: 21602175    Free PMC article.
Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block.
Maitreyee K Jathal, Liqun Chen, Maria Mudryj, Paramita M Ghosh.
Immunol Endocr Metab Agents Med Chem, 2011 May 24; 11(2). PMID: 21603064    Free PMC article.
P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation.
Yong Seok Kang, Wook Kim, +3 authors, Woo Keun Song.
PLoS One, 2011 Jun 01; 6(5). PMID: 21625594    Free PMC article.
Endocrine resistance in breast cancer: new roles for ErbB3 and ErbB4.
Robert L Sutherland.
Breast Cancer Res, 2011 Jun 07; 13(3). PMID: 21639949    Free PMC article.
Biomarkers of clinical benefit for anti-epidermal growth factor receptor agents in patients with non-small-cell lung cancer.
A G Pallis, D A Fennell, +3 authors, R Dziadziuszko.
Br J Cancer, 2011 Jun 10; 105(1). PMID: 21654681    Free PMC article.
Part 4: pharmacogenetic variability in anticancer pharmacodynamic drug effects.
Maarten J Deenen, Annemieke Cats, Jos H Beijnen, Jan H M Schellens.
Oncologist, 2011 Jun 11; 16(7). PMID: 21659612    Free PMC article.
Targeting tumor cell motility to prevent metastasis.
Trenis D Palmer, William J Ashby, John D Lewis, Andries Zijlstra.
Adv Drug Deliv Rev, 2011 Jun 15; 63(8). PMID: 21664937    Free PMC article.
RINQ: Reference-based Indexing for Network Queries.
Günhan Gülsoy, Tamer Kahveci.
Bioinformatics, 2011 Jun 21; 27(13). PMID: 21685064    Free PMC article.
The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.
Kideok Jin, Xiangjun Kong, +14 authors, Saraswati Sukumar.
Proc Natl Acad Sci U S A, 2011 Jun 22; 109(8). PMID: 21690342    Free PMC article.
Emerging antibody combinations in oncology.
Stephen J Demarest, Kandasamy Hariharan, Jianying Dong.
MAbs, 2011 Jun 24; 3(4). PMID: 21697653    Free PMC article.
IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance.
Colin D White, Zhigang Li, Deborah A Dillon, David B Sacks.
J Biol Chem, 2011 Jul 05; 286(34). PMID: 21724847    Free PMC article.
EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target.
K Iida, K Nakayama, +8 authors, K Miyazaki.
Br J Cancer, 2011 Jul 07; 105(3). PMID: 21730982    Free PMC article.
Designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo.
Jameel Ahmad Khan, Rachel A Kudgus, +10 authors, Priyabrata Mukherjee.
PLoS One, 2011 Jul 09; 6(6). PMID: 21738572    Free PMC article.
Mammalian target of rapamycin: a central node of complex signaling cascades.
Yoh Dobashi, Yasutaka Watanabe, +2 authors, Shinichiro Koyama.
Int J Clin Exp Pathol, 2011 Jul 09; 4(5). PMID: 21738819    Free PMC article.
EGFR expression in advanced head and neck cutaneous squamous cell carcinoma.
Larissa Sweeny, Nichole R Dean, +5 authors, Eben L Rosenthal.
Head Neck, 2011 Jul 09; 34(5). PMID: 21739514    Free PMC article.
Breast Tumor Angiogenesis and Tumor-Associated Macrophages: Histopathologist's Perspective.
Ewe Seng Ch'ng, Hasnan Jaafar, Sharifah Emilia Tuan Sharif.
Patholog Res Int, 2011 Jul 13; 2011. PMID: 21747968    Free PMC article.
Receptor-tyrosine-kinase-targeted therapies for head and neck cancer.
Lisa A Elferink, Vicente A Resto.
J Signal Transduct, 2011 Jul 22; 2011. PMID: 21776391    Free PMC article.
The genomics of lung adenocarcinoma: opportunities for targeted therapies.
Heidi Greulich.
Genes Cancer, 2011 Jul 23; 1(12). PMID: 21779443    Free PMC article.
MYC and Breast Cancer.
Jinhua Xu, Yinghua Chen, Olufunmilayo I Olopade.
Genes Cancer, 2011 Jul 23; 1(6). PMID: 21779462    Free PMC article.
Highly Cited.
The challenge of developing robust drugs to overcome resistance.
Amy C Anderson, Michael P Pollastri, Celia A Schiffer, Norton P Peet.
Drug Discov Today, 2011 Jul 26; 16(17-18). PMID: 21784168    Free PMC article.
Dual kinase inhibition of EGFR and HER2 overcomes resistance to cetuximab in a novel in vivo model of acquired cetuximab resistance.
Kelly M Quesnelle, Jennifer R Grandis.
Clin Cancer Res, 2011 Jul 28; 17(18). PMID: 21791633    Free PMC article.
Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma.
Mikiko Takikita, Ran Xie, +5 authors, Stephen M Hewitt.
J Transl Med, 2011 Aug 02; 9. PMID: 21801427    Free PMC article.
Epidermal growth factor receptor mutations in colorectal cancer patients.
Bo-Young Oh, Ryung-Ah Lee, Soon-Sup Chung, Kwang Ho Kim.
J Korean Soc Coloproctol, 2011 Aug 11; 27(3). PMID: 21829767    Free PMC article.
Physical-chemical principles underlying RTK activation, and their implications for human disease.
Lijuan He, Kalina Hristova.
Biochim Biophys Acta, 2011 Aug 16; 1818(4). PMID: 21840295    Free PMC article.
Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance.
Kamal K Balavenkatraman, Nicola Aceto, +4 authors, Mohamed Bentires-Alj.
Mol Cancer Res, 2011 Aug 19; 9(10). PMID: 21849469    Free PMC article.
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.
Alexandra R Grassian, Christian M Metallo, +2 authors, Joan S Brugge.
Genes Dev, 2011 Aug 20; 25(16). PMID: 21852536    Free PMC article.
EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization.
Simone Filosto, Elaine M Khan, +4 authors, Tzipora Goldkorn.
PLoS One, 2011 Aug 20; 6(8). PMID: 21853092    Free PMC article.
An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression.
Marc Leushacke, Ralf Spörle, +6 authors, Markus Morkel.
PLoS One, 2011 Aug 20; 6(8). PMID: 21853123    Free PMC article.
Structure-activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell lines.
Sashikanth Banappagari, Sharon Ronald, Seetharama D Satyanarayanajois.
Medchemcomm, 2011 Sep 03; 2(8). PMID: 21887403    Free PMC article.
Rac signaling in breast cancer: a tale of GEFs and GAPs.
Eva Wertheimer, Alvaro Gutierrez-Uzquiza, +3 authors, Marcelo G Kazanietz.
Cell Signal, 2011 Sep 07; 24(2). PMID: 21893191    Free PMC article.
Highly Cited. Review.
A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death.
Carla Lucia Esposito, Diana Passaro, +5 authors, Laura Cerchia.
PLoS One, 2011 Sep 15; 6(9). PMID: 21915281    Free PMC article.
Posttranscriptional regulation of cancer traits by HuR.
Kotb Abdelmohsen, Myriam Gorospe.
Wiley Interdiscip Rev RNA, 2011 Sep 22; 1(2). PMID: 21935886    Free PMC article.
Highly Cited. Review.
Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR.
George Santis, Roger Angell, +7 authors, Khalid Tobal.
PLoS One, 2011 Sep 29; 6(9). PMID: 21949883    Free PMC article.
The combination of gefitinib and RAD001 inhibits growth of HER2 overexpressing breast cancer cells and tumors irrespective of trastuzumab sensitivity.
Wieslawa H Dragowska, Sherry A Weppler, +9 authors, Marcel B Bally.
BMC Cancer, 2011 Oct 04; 11. PMID: 21961653    Free PMC article.
Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.
Toshi Menju, Shigeru Hashimoto, +7 authors, Hisataka Sabe.
PLoS One, 2011 Oct 04; 6(9). PMID: 21966491    Free PMC article.
Platinum resistance in breast and ovarian cancer cell lines.
Niels Eckstein.
J Exp Clin Cancer Res, 2011 Oct 05; 30. PMID: 21967738    Free PMC article.
Targeted protein-omic methods are bridging the gap between proteomic and hypothesis-driven protein analysis approaches.
Ronald J Hause, Hyung-Do Kim, Kin K Leung, Richard Baker Jones.
Expert Rev Proteomics, 2011 Oct 18; 8(5). PMID: 21999828    Free PMC article.
Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.
Kunal S Taskar, Vinay Rudraraju, +12 authors, Quentin R Smith.
Pharm Res, 2011 Oct 21; 29(3). PMID: 22011930    Free PMC article.
N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells.
Mai Yamauchi, Ikuyo Yoshino, +9 authors, Noriko Gotoh.
Am J Cancer Res, 2011 Oct 22; 1(7). PMID: 22016830    Free PMC article.
An in vitro multistep carcinogenesis model for both HPV-positive and -negative human oral squamous cell carcinomas.
Yusuke Zushi, Mako Narisawa-Saito, +6 authors, Tohru Kiyono.
Am J Cancer Res, 2011 Oct 22; 1(7). PMID: 22016834    Free PMC article.
Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2⁺ metastatic breast cancer.
Hilda Wong, Roland Leung, +4 authors, Thomas Yau.
Oncologist, 2011 Oct 25; 16(11). PMID: 22020213    Free PMC article.
Winning the arms race by improving drug discovery against mutating targets.
Amy C Anderson.
ACS Chem Biol, 2011 Nov 05; 7(2). PMID: 22050347    Free PMC article.
Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm.
Y Ardeshirpour, V Chernomordik, +6 authors, A Gandjbakhche.
Technol Cancer Res Treat, 2011 Nov 10; 10(6). PMID: 22066595    Free PMC article.
The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding.
Sangeeta Adak, Katherine S Yang, Jennifer Macdonald-Obermann, Linda J Pike.
J Biol Chem, 2011 Nov 10; 286(52). PMID: 22069315    Free PMC article.
Mechanistic insights into the activation of oncogenic forms of EGF receptor.
Zhihong Wang, Patti A Longo, +4 authors, Philip A Cole.
Nat Struct Mol Biol, 2011 Nov 22; 18(12). PMID: 22101934    Free PMC article.
Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells.
Tracy R Daniels, Richard K Leuchter, +6 authors, Manuel L Penichet.
Cancer Immunol Immunother, 2011 Dec 01; 61(7). PMID: 22127364    Free PMC article.
Protein expression signatures for inhibition of epidermal growth factor receptor-mediated signaling.
Matthew V Myers, H Charles Manning, Robert J Coffey, Daniel C Liebler.
Mol Cell Proteomics, 2011 Dec 08; 11(2). PMID: 22147731    Free PMC article.
ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer.
Jian Pan, Li-Chao Sun, +14 authors, Jian Ni.
J Transl Med, 2011 Dec 14; 9. PMID: 22152132    Free PMC article.
Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer.
Gary E Gallick, Paul G Corn, Amado J Zurita, Sue-Hwa Lin.
Future Med Chem, 2011 Dec 16; 4(1). PMID: 22168167    Free PMC article.
IQGAP1 and its binding proteins control diverse biological functions.
Colin D White, Huseyin H Erdemir, David B Sacks.
Cell Signal, 2011 Dec 21; 24(4). PMID: 22182509    Free PMC article.
Highly Cited. Review.
The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model.
Hu Ma, Quan Yao, +5 authors, Zheng-Tang Chen.
Molecules, 2011 Dec 21; 16(12). PMID: 22183882    Free PMC article.
Efficient blockade of Akt signaling is a determinant factor to overcome resistance to matuzumab.
Debora D Meira, Vitor H Almeida, +5 authors, Carlos G Ferreira.
Mol Cancer, 2011 Dec 22; 10. PMID: 22185378    Free PMC article.
Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging.
Jennifer L Macdonald-Obermann, David Piwnica-Worms, Linda J Pike.
Proc Natl Acad Sci U S A, 2011 Dec 23; 109(1). PMID: 22190492    Free PMC article.
PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells.
Allan Siu, Carl Virtanen, Jan Jongstra.
Oncotarget, 2011 Dec 24; 2(12). PMID: 22193779    Free PMC article.
Animal models for IgE-meditated cancer immunotherapy.
Tracy R Daniels, Otoniel Martínez-Maza, Manuel L Penichet.
Cancer Immunol Immunother, 2011 Dec 24; 61(9). PMID: 22193986    Free PMC article.
Cooperative Hedgehog-EGFR signaling.
Doris Mangelberger, Daniela Kern, +2 authors, Fritz Aberger.
Front Biosci (Landmark Ed), 2011 Dec 29; 17. PMID: 22201734    Free PMC article.
Heparin-binding epidermal growth factor-like growth factor is a potent regulator of invasion activity in oral squamous cell carcinoma.
Yuichi Ohnishi, Hiroshi Inoue, +2 authors, Masami Nozaki.
Oncol Rep, 2012 Jan 03; 27(4). PMID: 22209887    Free PMC article.
The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.
Kristy J Wilson, Christopher P Mill, +4 authors, David J Riese.
Biochem J, 2012 Jan 06; 443(1). PMID: 22216880    Free PMC article.
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
Yong Tang, Hossein A Hamed, +3 authors, Paul Dent.
Mol Pharmacol, 2012 Jan 06; 81(4). PMID: 22219388    Free PMC article.
Potential for clinical radionuclide-based imaging and therapy of common cancers expressing EGFR-family receptors.
Jörgen Carlsson.
Tumour Biol, 2012 Jan 10; 33(3). PMID: 22228543
Anti-epidermal growth factor receptor therapy for advanced head and neck squamous cell carcinoma: a meta-analysis.
Shoude Zhang, Jia Chen, +2 authors, Beibei Yang.
Eur J Clin Pharmacol, 2012 Jan 11; 68(5). PMID: 22231637
Phase I first-in-human study of TAK-285, a novel investigational dual HER2/EGFR inhibitor, in cancer patients.
T Doi, H Takiuchi, +10 authors, R Tsutsumi.
Br J Cancer, 2012 Jan 14; 106(4). PMID: 22240796    Free PMC article.
Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology.
Dimitrios Tsapralis, Ioannis Panayiotides, +2 authors, Eva Karamitopoulou.
World J Gastroenterol, 2012 Jan 19; 18(2). PMID: 22253521    Free PMC article.
Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherol.
Amanda K Smolarek, Nanjoo Suh.
Nutrients, 2012 Jan 19; 3(11). PMID: 22254089    Free PMC article.
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial.
José Baselga, Ian Bradbury, +25 authors, NeoALTTO Study Team.
Lancet, 2012 Jan 20; 379(9816). PMID: 22257673    Free PMC article.
Highly Cited.
Optimizing the use of epidermal growth factor receptor inhibitors in advanced non-small-lung cancer (NSCLC).
Emad Shash, Fedro Alessandro Peccatori, Hatem A Azim.
J Thorac Dis, 2012 Jan 21; 3(1). PMID: 22263061    Free PMC article.
Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance.
T E Taylor, F B Furnari, W K Cavenee.
Curr Cancer Drug Targets, 2012 Jan 25; 12(3). PMID: 22268382    Free PMC article.
Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.
Takumi Kawabata, Susumu Tanimura, +3 authors, Michiaki Kohno.
J Biol Chem, 2012 Jan 25; 287(13). PMID: 22270368    Free PMC article.
Domain-based biosensor assay to screen for epidermal growth factor receptor modulators in live cells.
Christophe Antczak, Alun Bermingham, +4 authors, Hakim Djaballah.
Assay Drug Dev Technol, 2012 Jan 28; 10(1). PMID: 22280060    Free PMC article.
A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population.
Qiang Yu, Chun-Xiao Zhou, +3 authors, Jin-Kun Zhang.
World J Gastroenterol, 2012 Feb 02; 18(4). PMID: 22294845    Free PMC article.
Role of HER2-Targeted Agents in Adjuvant Treatment for Breast Cancer.
Toru Mukohara.
Chemother Res Pract, 2012 Feb 02; 2011. PMID: 22295205    Free PMC article.
Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer.
Gabriel L Fiszman, María A Jasnis.
Int J Breast Cancer, 2012 Feb 02; 2011. PMID: 22295219    Free PMC article.
Treatment of nonsmall cell lung cancer: overcoming the resistance to epidermal growth factor receptor inhibitors.
Corey A Carter, Giuseppe Giaccone.
Curr Opin Oncol, 2012 Feb 09; 24(2). PMID: 22314615    Free PMC article.
A crossroad of microRNAs and immediate early genes (IEGs) encoding oncogenic transcription factors in breast cancer.
Aldema Sas-Chen, Roi Avraham, Yosef Yarden.
J Mammary Gland Biol Neoplasia, 2012 Feb 14; 17(1). PMID: 22327345
EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR.
Kouki Ishikawa, Atsuki Nara, Kunihiro Matsumoto, Hiroshi Hanafusa.
Mol Biol Cell, 2012 Feb 18; 23(7). PMID: 22337768    Free PMC article.
Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.
Nichola Cruickshanks, Hossein A Hamed, +4 authors, Paul Dent.
Mol Pharmacol, 2012 Feb 24; 81(5). PMID: 22357666    Free PMC article.
Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas.
Gordon Li, Siddhartha S Mitra, +4 authors, Albert J Wong.
J Neurooncol, 2012 Mar 03; 108(3). PMID: 22382786    Free PMC article.
Slow down to stay alive: HER4 protects against cellular stress and confers chemoresistance in neuroblastoma.
Yingqi Hua, Kirill Gorshkov, +3 authors, Dennis P M Hughes.
Cancer, 2012 Mar 15; 118(20). PMID: 22415601    Free PMC article.
A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab.
Nancy U Lin, Eric P Winer, +13 authors, Tamas Hickish.
Breast Cancer Res Treat, 2012 Mar 16; 133(3). PMID: 22418700    Free PMC article.
177Lu-DO3A-HSA-Z EGFR:1907: characterization as a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas.
Susan Hoppmann, Shibo Qi, +5 authors, Zhen Cheng.
J Biol Inorg Chem, 2012 Mar 16; 17(5). PMID: 22418921
Inference of modules associated to eQTLs.
Anat Kreimer, Oren Litvin, +3 authors, Itsik Pe'er.
Nucleic Acids Res, 2012 Mar 27; 40(13). PMID: 22447449    Free PMC article.
EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
Jung-Chien Cheng, Nelly Auersperg, Peter C K Leung.
PLoS One, 2012 Apr 06; 7(3). PMID: 22479527    Free PMC article.
ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer.
Kunihiko Hinohara, Seiichiro Kobayashi, +10 authors, Noriko Gotoh.
Proc Natl Acad Sci U S A, 2012 Apr 12; 109(17). PMID: 22492965    Free PMC article.
BRCA1-IRIS overexpression promotes formation of aggressive breast cancers.
Yoshiko Shimizu, Hugh Luk, +6 authors, Wael M ElShamy.
PLoS One, 2012 Apr 19; 7(4). PMID: 22511931    Free PMC article.
Tyrosine kinase inhibitors in lung cancer.
Anish Thomas, Arun Rajan, Giuseppe Giaccone.
Hematol Oncol Clin North Am, 2012 Apr 24; 26(3). PMID: 22520981    Free PMC article.
Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
Yiwei Gao, Velasco Cimica, Nancy C Reich.
J Biol Chem, 2012 May 02; 287(25). PMID: 22547065    Free PMC article.
A new analysis approach of epidermal growth factor receptor pathway activation patterns provides insights into cetuximab resistance mechanisms in head and neck cancer.
Silvia von der Heyde, Tim Beissbarth.
BMC Med, 2012 May 03; 10. PMID: 22548923    Free PMC article.
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.
Claus-Werner Franzke, Cristina Cobzaru, +7 authors, Carl P Blobel.
J Exp Med, 2012 May 09; 209(6). PMID: 22565824    Free PMC article.
Monoclonal antibody therapy of pancreatic cancer with cetuximab: potential for immune modulation.
Eric Luedke, Alena Cristina Jaime-Ramirez, Neela Bhave, William E Carson.
J Immunother, 2012 May 12; 35(5). PMID: 22576341    Free PMC article.
Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein.
Maria Sundvall, Anna Korhonen, +7 authors, Klaus Elenius.
J Biol Chem, 2012 May 16; 287(27). PMID: 22584572    Free PMC article.
Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors.
Igor Vivanco, H Ian Robins, +36 authors, Ingo K Mellinghoff.
Cancer Discov, 2012 May 17; 2(5). PMID: 22588883    Free PMC article.
Highly Cited.
Spatial regulation of receptor tyrosine kinases in development and cancer.
Jessica B Casaletto, Andrea I McClatchey.
Nat Rev Cancer, 2012 May 25; 12(6). PMID: 22622641    Free PMC article.
Highly Cited. Review.
A functional comparison between the HER2(high)/HER3 and the HER2(low)/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells.
Sangmin Kim, Jeonghun Han, +3 authors, Seok Jin Nam.
Exp Mol Med, 2012 May 26; 44(8). PMID: 22627808    Free PMC article.
Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion.
Takaya Shimura, Michihiro Yoshida, +8 authors, Takashi Joh.
BMC Cancer, 2012 Jun 01; 12. PMID: 22646534    Free PMC article.
Gliotransmission by prostaglandin e(2): a prerequisite for GnRH neuronal function?
Jerome Clasadonte, Ariane Sharif, Marc Baroncini, Vincent Prevot.
Front Endocrinol (Lausanne), 2011 Jan 01; 2. PMID: 22649391    Free PMC article.
Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer.
Hirohito Yamaguchi, Jennifer L Hsu, Mien-Chie Hung.
Front Oncol, 2012 Jun 01; 2. PMID: 22649777    Free PMC article.
Nucleic acids in human glioma treatment: innovative approaches and recent results.
S Catuogno, C L Esposito, +3 authors, L Cerchia.
J Signal Transduct, 2012 Jun 12; 2012. PMID: 22685651    Free PMC article.
Inhibition of protein-protein interaction of HER2-EGFR and HER2-HER3 by a rationally designed peptidomimetic.
Sashikanth Banappagari, Miriam Corti, Seth Pincus, Seetharama Satyanarayanajois.
J Biomol Struct Dyn, 2012 Jun 27; 30(5). PMID: 22731912    Free PMC article.
Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.
Yasuhito Onodera, Jin-Min Nam, +4 authors, Hisataka Sabe.
J Cell Biol, 2012 Jun 27; 197(7). PMID: 22734003    Free PMC article.
Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application.
Yongchao Zhao, Yi Sun.
Neoplasia, 2012 Jun 30; 14(5). PMID: 22745582    Free PMC article.
Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.
Suresh S Ramalingam, Fiona Blackhall, +14 authors, Michael Boyer.
J Clin Oncol, 2012 Jul 04; 30(27). PMID: 22753918    Free PMC article.
Highly Cited.
HER2 as a therapeutic target in the gastric cancer: is it sufficient?
Rupesh Chaturvedi, Amar B Singh.
Indian J Gastroenterol, 2012 Jul 06; 31(3). PMID: 22763895    Free PMC article.
Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations.
C M Furcht, A R Muñoz Rojas, D Nihalani, M J Lazzara.
Oncogene, 2012 Jul 11; 32(18). PMID: 22777356    Free PMC article.
Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration.
Wei Liu, Daniel K Hsu, +4 authors, Fu-Tong Liu.
J Invest Dermatol, 2012 Jul 13; 132(12). PMID: 22785133    Free PMC article.
Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells.
Yu-Chin Lin, Meng-Hsuan Wu, +4 authors, Ching-Chow Chen.
Neoplasia, 2012 Jul 13; 14(6). PMID: 22787428    Free PMC article.
A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction.
Sun Tian, Iris Simon, +7 authors, Gabriel Capella.
Gut, 2012 Jul 17; 62(4). PMID: 22798500    Free PMC article.
Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.
Parul Gupta, Sanjay K Srivastava.
BMC Med, 2012 Jul 25; 10. PMID: 22824293    Free PMC article.
Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.
Gábor Bögel, Annamária Gujdár, +5 authors, László Buday.
J Biol Chem, 2012 Jul 26; 287(37). PMID: 22829589    Free PMC article.
Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-γ and STAT3 protein signaling pathways.
Yunwei Ou, Ling Ma, +9 authors, Yongmei Song.
J Biol Chem, 2012 Jul 31; 287(39). PMID: 22843679    Free PMC article.
Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer.
Sae-Won Han, Yongjun Cha, +13 authors, Tae-You Kim.
PLoS One, 2012 Aug 01; 7(7). PMID: 22848366    Free PMC article.
Isolation and characterization of erlotinib-resistant human non-small cell lung cancer A549 cells.
Ryuji Ikeda, Lee C Vermeulen, +4 authors, Jill M Kolesar.
Oncol Lett, 2011 Jan 01; 2(1). PMID: 22870135    Free PMC article.
Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy.
Kvar C L Black, Ji Yi, +2 authors, Phillip B Messersmith.
Nanomedicine (Lond), 2012 Aug 16; 8(1). PMID: 22891865    Free PMC article.
Peptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy.
Pravin T P Kaumaya, Kevin Chu Foy.
Future Oncol, 2012 Aug 17; 8(8). PMID: 22894670    Free PMC article.
Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells.
Rian J Dickstein, Giovanni Nitti, +3 authors, David J McConkey.
Cancer Biol Ther, 2012 Aug 17; 13(13). PMID: 22895070    Free PMC article.
Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR.
Fen Wang, Shuhang Wang, +6 authors, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education).
J Exp Clin Cancer Res, 2012 Aug 21; 31. PMID: 22901364    Free PMC article.
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators.
Bernd Bodenmiller, Eli R Zunder, +8 authors, Garry P Nolan.
Nat Biotechnol, 2012 Aug 21; 30(9). PMID: 22902532    Free PMC article.
Highly Cited.
Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties.
R Castoldi, U Jucknischke, +5 authors, C Sustmann.
Protein Eng Des Sel, 2012 Sep 01; 25(10). PMID: 22936109    Free PMC article.
An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs.
Young-Ki Bae, Jee Young Sung, +6 authors, Jaegal Shim.
PLoS One, 2012 Sep 08; 7(9). PMID: 22957020    Free PMC article.
Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.
Ronald J Hause, Kin K Leung, +3 authors, Richard B Jones.
PLoS One, 2012 Sep 14; 7(9). PMID: 22973453    Free PMC article.
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.
Chafen Lu, Li-Zhi Mi, +2 authors, Timothy A Springer.
J Biol Chem, 2012 Sep 19; 287(45). PMID: 22988250    Free PMC article.
Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.
Nichola Cruickshanks, Yong Tang, +3 authors, Paul Dent.
Mol Pharmacol, 2012 Sep 20; 82(6). PMID: 22989520    Free PMC article.
Cetuximab-mediated tumor regression depends on innate and adaptive immune responses.
Xuanming Yang, Xunmin Zhang, +3 authors, Yang-Xin Fu.
Mol Ther, 2012 Sep 20; 21(1). PMID: 22990672    Free PMC article.
Electrolyte and protein imbalance following anti-EGFR therapy in cancer patients: A comparative study.
Pius Maliakal, Andrea Ledford.
Exp Ther Med, 2010 Mar 01; 1(2). PMID: 22993543    Free PMC article.
Antibody-linked spherical nucleic acids for cellular targeting.
Ke Zhang, Liangliang Hao, Sarah J Hurst, Chad A Mirkin.
J Am Chem Soc, 2012 Oct 02; 134(40). PMID: 23020598    Free PMC article.
Chapter seven--Cancer treatment with gene therapy and radiation therapy.
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Adv Cancer Res, 2012 Oct 02; 115. PMID: 23021246    Free PMC article.
Effects of paclitaxel on EGFR endocytic trafficking revealed using quantum dot tracking in single cells.
Hui Li, Zhao-Wen Duan, +4 authors, Peng-Ye Wang.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029028    Free PMC article.
Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping.
Julia D Wulfkuhle, Daniela Berg, +17 authors, Emanuel F Petricoin.
Clin Cancer Res, 2012 Oct 10; 18(23). PMID: 23045247    Free PMC article.
Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations.
Alessandra Silvestri, Valerie Calvert, +10 authors, Mariaelena Pierobon.
Clin Exp Metastasis, 2012 Oct 12; 30(3). PMID: 23053743    Free PMC article.
Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion.
Nicola Aceto, Stephan Duss, +4 authors, Mohamed Bentires-Alj.
Breast Cancer Res, 2012 Oct 16; 14(5). PMID: 23062209    Free PMC article.
Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo.
Lesley-Ann Martin, Sunil Pancholi, +10 authors, Mitch Dowsett.
Breast Cancer Res, 2012 Oct 19; 14(5). PMID: 23075476    Free PMC article.
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.
Bhopal Mohapatra, Gulzar Ahmad, +15 authors, Hamid Band.
Biochim Biophys Acta, 2012 Oct 23; 1833(1). PMID: 23085373    Free PMC article.
Highly Cited. Review.
Simulation of homology models for the extracellular domains (ECD) of ErbB3, ErbB4 and the ErbB2-ErbB3 complex in their active conformations.
Juan Felipe Franco-Gonzalez, Javier Ramos, Victor L Cruz, Javier Martínez-Salazar.
J Mol Model, 2012 Oct 24; 19(2). PMID: 23090500
Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers.
Alaina P Boyer, Timothy S Collier, Ilan Vidavsky, Ron Bose.
Mol Cell Proteomics, 2012 Oct 30; 12(1). PMID: 23105007    Free PMC article.
The Role of EGFR and HER2- Activating Mutations in Maxillary Sinus Cancer.
Patricia Ene, Radu Cristian Popescu, +5 authors, Catalin Cîrstoiu.
Maedica (Bucur), 2012 Nov 03; 7(1). PMID: 23118824    Free PMC article.
Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression.
Gholamreza Bidkhori, Ali Moeini, Ali Masoudi-Nejad.
PLoS One, 2012 Nov 08; 7(10). PMID: 23133538    Free PMC article.
Computational design of a CNT carrier for a high affinity bispecific anti-HER2 antibody based on trastuzumab and pertuzumab Fabs.
Karim Salazar-Salinas, Carlos Kubli-Garfias, Jorge M Seminario.
J Mol Model, 2012 Nov 13; 19(7). PMID: 23143677
Conformational flexibility of the ErbB2 ectodomain and trastuzumab antibody complex as revealed by molecular dynamics and principal component analysis.
Juan Felipe Franco-Gonzalez, Victor L Cruz, Javier Ramos, Javier Martínez-Salazar.
J Mol Model, 2012 Nov 20; 19(3). PMID: 23160933
A Phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors.
John Marshall, Jimmy Hwang, +7 authors, Nancy L Lewis.
Invest New Drugs, 2012 Nov 20; 31(2). PMID: 23161335    Free PMC article.
Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides.
R L Juliano, K Carver, C Cao, X Ming.
J Drug Target, 2012 Nov 21; 21(1). PMID: 23163768    Free PMC article.
Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.
Nicholas K Tonks.
FEBS J, 2012 Nov 28; 280(2). PMID: 23176256    Free PMC article.
Highly Cited. Review.
Advances in Targeting HER3 as an Anticancer Therapy.
Ning Jiang, Nabil F Saba, Zhuo Georgia Chen.
Chemother Res Pract, 2012 Dec 01; 2012. PMID: 23198146    Free PMC article.
Single molecule fluorescence detection and tracking in mammalian cells: the state-of-the-art and future perspectives.
Marisa L Martin-Fernandez, David T Clarke.
Int J Mol Sci, 2012 Dec 04; 13(11). PMID: 23203092    Free PMC article.
Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling.
Lu Yang, Yun Li, +3 authors, Yuesheng Zhang.
J Biol Chem, 2012 Dec 06; 288(4). PMID: 23212918    Free PMC article.
Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.
Jiyoung Park, Venetia R Sarode, +2 authors, Philipp E Scherer.
Proc Natl Acad Sci U S A, 2012 Dec 06; 109(51). PMID: 23213231    Free PMC article.
Membrane microdomain-associated uroplakin IIIa contributes to Src-dependent mechanisms of anti-apoptotic proliferation in human bladder carcinoma cells.
Shigeru Kihira, Junpei Yoshida, +8 authors, Ken-Ichi Sato.
Biol Open, 2012 Dec 06; 1(10). PMID: 23213380    Free PMC article.
Activating HER2 mutations in HER2 gene amplification negative breast cancer.
Ron Bose, Shyam M Kavuri, +11 authors, Matthew J Ellis.
Cancer Discov, 2012 Dec 12; 3(2). PMID: 23220880    Free PMC article.
Highly Cited.
Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells.
V Folgiero, S E Di Carlo, +10 authors, R Falcioni.
Cell Death Dis, 2012 Dec 12; 3. PMID: 23222510    Free PMC article.
Systemic analysis of gene expression profiles identifies ErbB3 as a potential drug target in pediatric alveolar rhabdomyosarcoma.
Janne Nordberg, John Patrick Mpindi, +5 authors, Varpu Elenius.
PLoS One, 2012 Dec 12; 7(12). PMID: 23227212    Free PMC article.
ErbB3-binding protein EBP1 decreases ErbB2 levels via a transcriptional mechanism.
Arundhati Ghosh, Smita Awasthi, Anne W Hamburger.
Oncol Rep, 2012 Dec 18; 29(3). PMID: 23242156    Free PMC article.
Autocrine motility factor promotes HER2 cleavage and signaling in breast cancer cells.
Dhong Hyo Kho, Pratima Nangia-Makker, +4 authors, Avraham Raz.
Cancer Res, 2012 Dec 19; 73(4). PMID: 23248119    Free PMC article.
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells.
Kristine Kleivi Sahlberg, Vesa Hongisto, +9 authors, Olli Kallioniemi.
Mol Oncol, 2012 Dec 21; 7(3). PMID: 23253899    Free PMC article.
Targeting the human epidermal growth factor receptor 2 pathway in breast cancer.
Senthilkumar Damodaran, Erin M Olson.
Hosp Pract (1995), 2013 Jan 10; 40(4). PMID: 23299030    Free PMC article.
Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling.
S M Brouxhon, S Kyrkanides, +5 authors, L Ma.
Oncogene, 2013 Jan 16; 33(2). PMID: 23318419    Free PMC article.
Role of epidermal growth factor receptor in acute and chronic kidney injury.
Jinhua Tang, Na Liu, Shougang Zhuang.
Kidney Int, 2013 Jan 18; 83(5). PMID: 23325080    Free PMC article.
The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics.
Jessica M Scott, Susan Lakoski, +3 authors, Lee W Jones.
Oncologist, 2013 Jan 22; 18(2). PMID: 23335619    Free PMC article.
Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers.
Jüri Reimand, Gary D Bader.
Mol Syst Biol, 2013 Jan 24; 9. PMID: 23340843    Free PMC article.
Highly Cited.
ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells.
Byung-Kwon Choi, Xuejun Fan, +2 authors, Zhiqiang An.
Cancer Med, 2013 Jan 24; 1(1). PMID: 23342251    Free PMC article.
Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models.
Amine Issa, Jason W Gill, +4 authors, Nancy E Hynes.
Breast Cancer Res, 2013 Jan 25; 15(1). PMID: 23343422    Free PMC article.
Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB.
Chien-Chih Ou, Yuan-Wu Chen, +4 authors, Jah-Yao Liu.
Evid Based Complement Alternat Med, 2013 Jan 25; 2012. PMID: 23346199    Free PMC article.
β4 Integrin signaling induces expansion of prostate tumor progenitors.
Toshiaki Yoshioka, Javier Otero, +12 authors, Filippo G Giancotti.
J Clin Invest, 2013 Jan 26; 123(2). PMID: 23348745    Free PMC article.
HER2-specific T lymphocytes kill both trastuzumab-resistant and trastuzumab-sensitive breast cell lines in vitro.
Xiao-Lin Lin, Xiao-Li Wang, +9 authors, Jun Ren.
Chin J Cancer Res, 2013 Jan 30; 24(2). PMID: 23357961    Free PMC article.
Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer.
A Ghosh, S Awasthi, J R Peterson, A W Hamburger.
Br J Cancer, 2013 Jan 31; 108(3). PMID: 23361053    Free PMC article.
A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.
Katherine R Singleton, Jihye Kim, +6 authors, Lynn E Heasley.
Mol Pharmacol, 2013 Feb 02; 83(4). PMID: 23371912    Free PMC article.
The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas.
Sittichai Koontongkaew.
J Cancer, 2013 Feb 07; 4(1). PMID: 23386906    Free PMC article.
Highly Cited.
[Molecular pathology of the lungs. New perspectives by next generation sequencing].
C Vollbrecht, K König, +2 authors, M Odenthal.
Pathologe, 2013 Feb 08; 34(1). PMID: 23389825
Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease.
Kadoaki Ohashi, Yosef E Maruvka, Franziska Michor, William Pao.
J Clin Oncol, 2013 Feb 13; 31(8). PMID: 23401451    Free PMC article.
Highly Cited. Review.
Dacomitinib, an irreversible Pan-ErbB inhibitor significantly abrogates growth in head and neck cancer models that exhibit low response to cetuximab.
Ferdows Ather, Habib Hamidi, +5 authors, Steven G Wong.
PLoS One, 2013 Feb 14; 8(2). PMID: 23405260    Free PMC article.
Erlotinib resistance in lung cancer: current progress and future perspectives.
Joy Tang, Rasha Salama, +2 authors, Aamir Ahmad.
Front Pharmacol, 2013 Feb 15; 4. PMID: 23407898    Free PMC article.
MUC4 overexpression augments cell migration and metastasis through EGFR family proteins in triple negative breast cancer cells.
Partha Mukhopadhyay, Imayavaramban Lakshmanan, +6 authors, Surinder K Batra.
PLoS One, 2013 Feb 15; 8(2). PMID: 23408941    Free PMC article.
Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in lung cancers.
Helena A Yu, Gregory J Riely.
J Natl Compr Canc Netw, 2013 Feb 16; 11(2). PMID: 23411383    Free PMC article.
Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases.
F Kong, J Zhang, +4 authors, P Zhou.
Oncogene, 2013 Feb 19; 33(8). PMID: 23416973    Free PMC article.
Negative transcriptional control of ERBB2 gene by MBP-1 and HDAC1: diagnostic implications in breast cancer.
Flavia Contino, Claudia Mazzarella, +6 authors, Salvatore Feo.
BMC Cancer, 2013 Feb 21; 13. PMID: 23421821    Free PMC article.
EGFR-targeted therapy for non-small cell lung cancer: focus on EGFR oncogenic mutation.
Alberto Antonicelli, Stefano Cafarotti, +12 authors, André Emanuel Dutly.
Int J Med Sci, 2013 Feb 21; 10(3). PMID: 23423768    Free PMC article.
Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion.
Hannah Johnson, Rebecca S Lescarbeau, Jesus A Gutierrez, Forest M White.
J Proteome Res, 2013 Feb 27; 12(4). PMID: 23438512    Free PMC article.
A phase II evaluation of gefitinib in the treatment of persistent or recurrent endometrial cancer: a Gynecologic Oncology Group study.
Kimberly K Leslie, Michael W Sill, +10 authors, Nita J Maihle.
Gynecol Oncol, 2013 Feb 27; 129(3). PMID: 23438670    Free PMC article.
Gene Expression Profiling Reveals Regulation of ERK Phosphorylation by Androgen-Induced Tumor Suppressor U19/EAF2 in the Mouse Prostate.
Fei Su, Bruna R S Correa, +3 authors, Zhou Wang.
Cancer Microenviron, 2013 Feb 27; 6(3). PMID: 23440596    Free PMC article.
Signal transduction and molecular targets of selected flavonoids.
Ann M Bode, Zigang Dong.
Antioxid Redox Signal, 2013 Mar 06; 19(2). PMID: 23458437    Free PMC article.
Reduction of the ST6 β-galactosamide α-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a.
Akihiro Minami, Yohei Shimono, +4 authors, Yoshimi Takai.
J Biol Chem, 2013 Mar 19; 288(17). PMID: 23504322    Free PMC article.
Genome-wide associations of signaling pathways in glioblastoma multiforme.
Stefan Wuchty, Alexei Vazquez, Serdar Bozdag, Peter O Bauer.
BMC Med Genomics, 2013 Mar 30; 6. PMID: 23537212    Free PMC article.
Cancer genome landscapes.
Bert Vogelstein, Nickolas Papadopoulos, +3 authors, Kenneth W Kinzler.
Science, 2013 Mar 30; 339(6127). PMID: 23539594    Free PMC article.
Highly Cited. Review.
A real-life experience using panitumumab in chemo-refractory metastatic colorectal cancer patients: a retrospective analysis at the Jewish General Hospital, 2009-2012.
A Mamo, M Cardoso Nogueira, +6 authors, P Kavan.
Curr Oncol, 2013 Apr 06; 20(2). PMID: 23559877    Free PMC article.
The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1.
C Voena, F Di Giacomo, +16 authors, G Inghirami.
Oncogenesis, 2013 Apr 10; 2. PMID: 23567620    Free PMC article.
Epidermal growth factor receptor as a therapeutic target in glioblastoma.
B Kalman, E Szep, F Garzuly, D E Post.
Neuromolecular Med, 2013 Apr 12; 15(2). PMID: 23575987
Identification of a novel antagonist of the ErbB1 receptor capable of inhibiting migration of human glioblastoma cells.
Mikkel Staberg, Christian Riemer, +3 authors, Vladimir Berezin.
Cell Oncol (Dordr), 2013 Apr 13; 36(3). PMID: 23580313
Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1.
Bo Cen, Sandeep Mahajan, Wenxue Wang, Andrew S Kraft.
Cancer Res, 2013 Apr 16; 73(11). PMID: 23585456    Free PMC article.
Is availability of anti-EGFR therapy for the colorectal adenocarcinomas showing fascin expression limited?
Nazım Emrah Koçer, Fazilet Kayaselçuk.
Target Oncol, 2013 Apr 17; 9(2). PMID: 23588415
Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors.
S Tjulandin, V Moiseyenko, +5 authors, U Keilholz.
Invest New Drugs, 2013 Apr 17; 32(1). PMID: 23589215
Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator.
Philip Vlaicu, Philipp Mertins, +6 authors, Axel Ullrich.
BMC Cancer, 2013 Apr 20; 13. PMID: 23597096    Free PMC article.
Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants.
Ying-Xin Fan, Lily Wong, +6 authors, Gibbes R Johnson.
J Biol Chem, 2013 Apr 25; 288(23). PMID: 23612964    Free PMC article.
Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment.
Grit S Herter-Sprie, Heidi Greulich, Kwok-Kin Wong.
Front Oncol, 2013 May 01; 3. PMID: 23630663    Free PMC article.
A comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells.
Tomáš Helikar, Naomi Kochi, +6 authors, Jim A Rogers.
PLoS One, 2013 May 03; 8(4). PMID: 23637902    Free PMC article.
Human epidermal growth factor receptor-2 expression in primary and metastatic gastric cancer.
Yiting Geng, Xiaofeng Chen, +5 authors, Yongmei Yin.
Int J Clin Oncol, 2013 May 11; 19(2). PMID: 23660785
Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury.
Jinhua Tang, Na Liu, +6 authors, Shougang Zhuang.
Am J Pathol, 2013 May 21; 183(1). PMID: 23684791    Free PMC article.
Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain.
Sashikanth Banappagari, Alecia McCall, +3 authors, Seetharama Satyanarayanajois.
Eur J Med Chem, 2013 May 22; 65. PMID: 23688700    Free PMC article.
Stromal EGF and igf-I together modulate plasticity of disseminated triple-negative breast tumors.
Zafira Castaño, Timothy Marsh, +7 authors, Sandra S McAllister.
Cancer Discov, 2013 May 22; 3(8). PMID: 23689072    Free PMC article.
Class I histone deacetylase activity is required for proliferation of renal epithelial cells.
Jinhua Tang, Yanli Yan, +3 authors, Shougang Zhuang.
Am J Physiol Renal Physiol, 2013 May 24; 305(3). PMID: 23698124    Free PMC article.
Induction of apoptosis and the regulation of ErbB signaling by laminarin in HT-29 human colon cancer cells.
Hee-Kyoung Park, In-Hye Kim, Joongkyun Kim, Taek-Jeong Nam.
Int J Mol Med, 2013 Jun 07; 32(2). PMID: 23739740    Free PMC article.
Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase.
Ludovico Sutto, Francesco Luigi Gervasio.
Proc Natl Acad Sci U S A, 2013 Jun 12; 110(26). PMID: 23754386    Free PMC article.
Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.
Jae Young So, Joseph E Wahler, +8 authors, Nanjoo Suh.
Cancer Prev Res (Phila), 2013 Jul 17; 6(9). PMID: 23856074    Free PMC article.
Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma.
Gholamreza Bidkhori, Zahra Narimani, +3 authors, Ali Masoudi-Nejad.
PLoS One, 2013 Jul 23; 8(7). PMID: 23874428    Free PMC article.
Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population.
Wen-Qing Li, Nan Hu, +20 authors, Philip R Taylor.
PLoS One, 2013 Jul 23; 8(7). PMID: 23874846    Free PMC article.
Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family.
Anton Arkhipov, Yibing Shan, +2 authors, David E Shaw.
Elife, 2013 Jul 24; 2. PMID: 23878723    Free PMC article.
Role of PKCα activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells.
Dayu Li, Marie A Shatos, Robin R Hodges, Darlene A Dartt.
Invest Ophthalmol Vis Sci, 2013 Jul 25; 54(8). PMID: 23882690    Free PMC article.
Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis.
Fabrizio Vinante, Antonella Rigo.
Toxins (Basel), 2013 Jul 31; 5(6). PMID: 23888518    Free PMC article.
Magnetic nanoparticles as mediators of ligand-free activation of EGFR signaling.
Atul A Bharde, Raghavendra Palankar, +4 authors, Donna J Arndt-Jovin.
PLoS One, 2013 Jul 31; 8(7). PMID: 23894364    Free PMC article.
Breast cancer metastasis: issues for the personalization of its prevention and treatment.
Natascia Marino, Stephan Woditschka, +4 authors, Patricia S Steeg.
Am J Pathol, 2013 Jul 31; 183(4). PMID: 23895915    Free PMC article.
Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues.
Josefa Steinhauer, Hui Hua Liu, Eli Miller, Jessica E Treisman.
J Cell Sci, 2013 Aug 02; 126(Pt 19). PMID: 23902690    Free PMC article.
Oral cavity and oropharyngeal squamous cell carcinoma genomics.
Marietta Tan, Jeffrey N Myers, Nishant Agrawal.
Otolaryngol Clin North Am, 2013 Aug 06; 46(4). PMID: 23910469    Free PMC article.
Targeting the MUC1-C oncoprotein downregulates HER2 activation and abrogates trastuzumab resistance in breast cancer cells.
D Raina, Y Uchida, +7 authors, D Kufe.
Oncogene, 2013 Aug 06; 33(26). PMID: 23912457    Free PMC article.
The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells.
Aaron S Meyer, Miles A Miller, Frank B Gertler, Douglas A Lauffenburger.
Sci Signal, 2013 Aug 08; 6(287). PMID: 23921085    Free PMC article.
Highly Cited.
EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5.
Anna Fekete, Gábor Bőgel, +3 authors, László Buday.
J Mol Signal, 2013 Aug 09; 8. PMID: 23924390    Free PMC article.
Optimization of substituted 6-salicyl-4-anilinoquinazoline derivatives as dual EGFR/HER2 tyrosine kinase inhibitors.
Dong-Dong Li, Ya-Juan Qin, +6 authors, Hai-Liang Zhu.
PLoS One, 2013 Aug 13; 8(8). PMID: 23936329    Free PMC article.
Upregulation of miR-136 in human non-small cell lung cancer cells promotes Erk1/2 activation by targeting PPP2R2A.
Sining Shen, Han Yue, +4 authors, Jiaxiang Wang.
Tumour Biol, 2013 Aug 21; 35(1). PMID: 23959478
PharmGKB summary: very important pharmacogene information for the epidermal growth factor receptor.
Ugur Hodoglugil, Michelle W Carrillo, +4 authors, Teri E Klein.
Pharmacogenet Genomics, 2013 Aug 22; 23(11). PMID: 23962910    Free PMC article.
copy number variation analysis in familial BRCA1/2-negative Finnish breast and ovarian cancer.
Kirsi M Kuusisto, Oyediran Akinrinade, +3 authors, Johanna Schleutker.
PLoS One, 2013 Aug 24; 8(8). PMID: 23967248    Free PMC article.
Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model.
Akiko Nakayama, Shinji Takagi, +6 authors, Yoshikazu Ohta.
J Cancer, 2013 Aug 29; 4(7). PMID: 23983820    Free PMC article.
The role of epidermal growth factor receptor in cancer metastasis and microenvironment.
Takamitsu Sasaki, Kuniyasu Hiroki, Yuichi Yamashita.
Biomed Res Int, 2013 Aug 30; 2013. PMID: 23986907    Free PMC article.
In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features.
Mingli Xiang, Kai Lei, +5 authors, Yirong Mo.
Drug Des Devel Ther, 2013 Aug 31; 7. PMID: 23990708    Free PMC article.
Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma.
Quan Wang, Feng Wei, +5 authors, Chunhai Hao.
PLoS One, 2013 Aug 31; 8(8). PMID: 23991179    Free PMC article.
RUNX3 is a prognostic marker and potential therapeutic target in human breast cancer.
Jin Bai, Hong-Mei Yong, +4 authors, Jun-Nian Zheng.
J Cancer Res Clin Oncol, 2013 Sep 05; 139(11). PMID: 24002642
Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor.
Zhihong Wang, Lily L Raines, +3 authors, Philip A Cole.
ACS Chem Biol, 2013 Sep 06; 8(11). PMID: 24004111    Free PMC article.
HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4).
James J Sollome, Elangovan Thavathiru, Todd D Camenisch, Richard R Vaillancourt.
Cell Signal, 2013 Sep 17; 26(1). PMID: 24036211    Free PMC article.
Screening for EGFR and KRAS mutations in non-small cell lung carcinomas using DNA extraction by hydrothermal pressure coupled with PCR-based direct sequencing.
Yan Liu, Bing-Quan Wu, +2 authors, Wei-Gang Fang.
Int J Clin Exp Pathol, 2013 Sep 17; 6(9). PMID: 24040454    Free PMC article.
The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells.
M-C Chen, C-H Chen, +4 authors, C-M Teng.
Cell Death Dis, 2013 Sep 21; 4. PMID: 24052078    Free PMC article.
Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.
Jeonghee Cho, Liang Chen, +13 authors, Matthew Meyerson.
Cancer Res, 2013 Sep 26; 73(22). PMID: 24063894    Free PMC article.
Targeted therapy for breast cancer prevention.
Petra den Hollander, Michelle I Savage, Powel H Brown.
Front Oncol, 2013 Sep 27; 3. PMID: 24069582    Free PMC article.
ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferation.
Shuo Qie, Clarissa Chu, +2 authors, Nianli Sang.
J Cell Biochem, 2013 Oct 15; 115(3). PMID: 24122876    Free PMC article.
A peptide antagonist of ErbB receptors, Inherbin3, induces neurite outgrowth from rat cerebellar granule neurons through ErbB1 inhibition.
Ruodan Xu, Stanislava Pankratova, +4 authors, Vladimir Berezin.
Neurochem Res, 2013 Oct 18; 38(12). PMID: 24132641
Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signaling.
R Kamekura, K N Kolegraff, +4 authors, A Nusrat.
Oncogene, 2013 Oct 30; 33(36). PMID: 24166502    Free PMC article.
EGF receptor and COX-1/COX-2 enzyme proteins as related to corresponding mRNAs in human per-operative biopsies of colorectal cancer.
Annika Gustafsson Asting, Ava Farivar, +3 authors, Kent Lundholm.
BMC Cancer, 2013 Nov 01; 13. PMID: 24171795    Free PMC article.
Antineoplastic effects of mammalian target of rapamycine inhibitors.
Maurizio Salvadori.
World J Transplant, 2013 Nov 01; 2(5). PMID: 24175199    Free PMC article.
Dmp1α inhibits HER2/neu-induced mammary tumorigenesis.
Elizabeth A Fry, Pankaj Taneja, +3 authors, Kazushi Inoue.
PLoS One, 2013 Nov 10; 8(10). PMID: 24205004    Free PMC article.
Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise.
Connie E Kim, Kam-Meng Tchou-Wong, William N Rom.
Cancers (Basel), 2011 Jan 01; 3(3). PMID: 24212941    Free PMC article.
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer.
Dingzhi Wang, Dianren Xia, Raymond N Dubois.
Cancers (Basel), 2011 Jan 01; 3(4). PMID: 24213116    Free PMC article.
SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion.
Arang Kwon, Hye-Lim Lee, +2 authors, Jeong-Hwa Baek.
Mol Cells, 2013 Nov 19; 36(6). PMID: 24241683    Free PMC article.
Overexpression of HER-2/neu protein attenuates the oxidative systemic profile in women diagnosed with breast cancer.
Vanessa J Victorino, Fernanda C Campos, +4 authors, Rubens Cecchini.
Tumour Biol, 2013 Nov 20; 35(4). PMID: 24248545
Enhanced PI3K p110α signaling confers acquired lapatinib resistance that can be effectively reversed by a p110α-selective PI3K inhibitor.
Samuel W Brady, Jian Zhang, +2 authors, Dihua Yu.
Mol Cancer Ther, 2013 Nov 20; 13(1). PMID: 24249715    Free PMC article.
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.
Jing Chen, Simona Torcia, +9 authors, Marco Conti.
Nat Cell Biol, 2013 Nov 26; 15(12). PMID: 24270888    Free PMC article.
Prolactinoma ErbB receptor expression and targeted therapy for aggressive tumors.
Odelia Cooper, Adam Mamelak, +5 authors, Anat Ben-Shlomo.
Endocrine, 2013 Nov 30; 46(2). PMID: 24287797    Free PMC article.
Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.
Melany J Wagner, Melissa M Stacey, Bernard A Liu, Tony Pawson.
Cold Spring Harb Perspect Biol, 2013 Dec 04; 5(12). PMID: 24296166    Free PMC article.
New treatment options for lung adenocarcinoma--in view of molecular background.
Nora Bittner, Gyula Ostoros, Lajos Géczi.
Pathol Oncol Res, 2013 Dec 07; 20(1). PMID: 24306880
Sex disparities in the association of lung adenocarcinoma with colorectal cancer.
Zhi-Hong Jian, Chia-Chi Lung, +4 authors, Yung-Po Liaw.
J Cancer, 2013 Dec 07; 4(9). PMID: 24312138    Free PMC article.
NF-κB activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth.
Shannon T Bailey, Penelope L Miron, +10 authors, K Biswas Debajit.
Mol Cancer Res, 2013 Dec 10; 12(3). PMID: 24319068    Free PMC article.
Microfluidic generated EGF-gradients induce chemokinesis of transplantable retinal progenitor cells via the JAK/STAT and PI3kinase signaling pathways.
Uchenna J Unachukwu, Moira Sauane, Maribel Vazquez, Stephen Redenti.
PLoS One, 2014 Jan 01; 8(12). PMID: 24376770    Free PMC article.
NOV-002, A Glutathione Disulfide Mimetic, Suppresses Tumor Cell Invasion and Metastasis.
Kiranmai Gumireddy, Anping Li, +5 authors, Qihong Huang.
J Carcinog Mutagen, 2014 Jan 01; 2013. PMID: 24377058    Free PMC article.
Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells.
Heiko Slanina, Sabrina Mündlein, Sabrina Hebling, Alexandra Schubert-Unkmeir.
Infect Immun, 2014 Jan 01; 82(3). PMID: 24379285    Free PMC article.
erbB3 is an active tyrosine kinase capable of homo- and heterointeractions.
Mara P Steinkamp, Shalini T Low-Nam, +3 authors, Bridget S Wilson.
Mol Cell Biol, 2014 Jan 01; 34(6). PMID: 24379439    Free PMC article.
Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology.
R L Juliano, Xin Ming, Kyle Carver, Brian Laing.
Nucleic Acid Ther, 2014 Jan 05; 24(2). PMID: 24383421    Free PMC article.
Molecular predictors of locoregional and distant metastases in oropharyngeal squamous cell carcinoma.
Brittany R Barber, Vincent L Biron, +3 authors, Hadi Seikaly.
J Otolaryngol Head Neck Surg, 2014 Jan 10; 42. PMID: 24401183    Free PMC article.
Targeting the tumor microenvironment with interferon-β bridges innate and adaptive immune responses.
Xuanming Yang, Xunmin Zhang, +4 authors, Yang-Xin Fu.
Cancer Cell, 2014 Jan 18; 25(1). PMID: 24434209    Free PMC article.
Highly Cited.
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling.
Marie Will, Alice Can Ran Qin, +11 authors, Neal Rosen.
Cancer Discov, 2014 Jan 18; 4(3). PMID: 24436048    Free PMC article.
Highly Cited.
Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress.
Yu-Chin Lin, Meng-Hsuan Wu, +5 authors, Ching-Chow Chen.
Oncotarget, 2014 Jan 25; 5(1). PMID: 24457597    Free PMC article.
Clinical update on cancer: molecular oncology of head and neck cancer.
Y Suh, I Amelio, T Guerrero Urbano, M Tavassoli.
Cell Death Dis, 2014 Jan 25; 5. PMID: 24457962    Free PMC article.
Highly Cited. Review.
EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo.
Gianluca Sala, Ilario Giovanni Rapposelli, +11 authors, Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO).
Transl Oncol, 2014 Jan 28; 6(6). PMID: 24466370    Free PMC article.
Propolis and its Active Component, Caffeic Acid Phenethyl Ester (CAPE), Modulate Breast Cancer Therapeutic Targets via an Epigenetically Mediated Mechanism of Action.
Coral Omene, Matko Kalac, +3 authors, Owen A O'Connor.
J Cancer Sci Ther, 2014 Jan 28; 5(10). PMID: 24466386    Free PMC article.
Development of anticancer drugs based on the hallmarks of tumor cells.
Natalia Bailón-Moscoso, Juan Carlos Romero-Benavides, Patricia Ostrosky-Wegman.
Tumour Biol, 2014 Jan 29; 35(5). PMID: 24470139
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer.
Armina A Kazi, Rabia A Gilani, +6 authors, Angela H Brodie.
Breast Cancer Res, 2014 Jan 30; 16(1). PMID: 24472707    Free PMC article.
Emerging biological treatments for uterine cervical carcinoma.
Patrizia Vici, Luciano Mariani, +11 authors, Aldo Venuti.
J Cancer, 2014 Feb 05; 5(2). PMID: 24494026    Free PMC article.
[Predictive biomarkers for tumor-relevant signaling pathways in molecular pathology].
I Bonzheim, F Fend.
Pathologe, 2014 Feb 06; 35(1). PMID: 24496994
Expression of signaling components in embryonic eyelid epithelium.
Qinghang Meng, Chang Jin, +3 authors, Ying Xia.
PLoS One, 2014 Feb 06; 9(2). PMID: 24498290    Free PMC article.
A phase 2 trial of dacomitinib (PF-00299804), an oral, irreversible pan-HER (human epidermal growth factor receptor) inhibitor, in patients with advanced non-small cell lung cancer after failure of prior chemotherapy and erlotinib.
Karen L Reckamp, Giuseppe Giaccone, +13 authors, Pasi A Jänne.
Cancer, 2014 Feb 07; 120(8). PMID: 24501009    Free PMC article.
Clinical pharmacology of tyrosine kinase inhibitors becoming generic drugs: the regulatory perspective.
Niels Eckstein, Lea Röper, +5 authors, Harald Enzmann.
J Exp Clin Cancer Res, 2014 Feb 08; 33. PMID: 24502453    Free PMC article.
Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling.
Marek Pruszynski, Eftychia Koumarianou, +5 authors, Michael R Zalutsky.
J Nucl Med, 2014 Mar 01; 55(4). PMID: 24578241    Free PMC article.
CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation.
Pietri Puustinen, Anna Rytter, +3 authors, Marja Jäättelä.
J Cell Biol, 2014 Mar 05; 204(5). PMID: 24590173    Free PMC article.
Mutation status of somatic EGFR and KRAS genes in Chinese patients with prostate cancer (PCa).
Meng Fu, Wei Zhang, +4 authors, Jimao Zhao.
Virchows Arch, 2014 Mar 07; 464(5). PMID: 24595526
Drug Resistance Mechanisms in Non-Small Cell Lung Carcinoma.
Janet Wangari-Talbot, Elizabeth Hopper-Borge.
J Can Res Updates, 2014 Mar 19; 2(4). PMID: 24634705    Free PMC article.
HER2 expression in primary gastric cancers and paired synchronous lymph node and liver metastases. A possible road to target HER2 with radionuclides.
Qichun Wei, Jing Xu, +4 authors, Jorgen Carlsson.
Tumour Biol, 2014 Mar 20; 35(7). PMID: 24643685
Targeted therapy in HER2-positive breast cancer.
Shu Guang Li, Li Li.
Biomed Rep, 2014 Mar 22; 1(4). PMID: 24648975    Free PMC article.
Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances.
Peter Lanzerstorfer, Daniela Borgmann, +3 authors, Julian Weghuber.
PLoS One, 2014 Mar 25; 9(3). PMID: 24658383    Free PMC article.
Extracellular signal-regulated kinase (ERK) expression and activation in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival.
Stamatios Theocharis, Ioly Kotta-Loizou, +6 authors, Xavier Sastre-Garau.
Tumour Biol, 2014 Apr 01; 35(7). PMID: 24682903
Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.
Tzipora Goldkorn, Simone Filosto, Samuel Chung.
Antioxid Redox Signal, 2014 Apr 02; 21(15). PMID: 24684526    Free PMC article.
Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies.
Valentina Rapozzi, Sonia Zorzet, +3 authors, Luigi E Xodo.
Mol Cancer, 2014 Apr 02; 13. PMID: 24684778    Free PMC article.
Conditions of tumor-associated antigens as a proper target for therapeutic antibodies against solid cancers.
Y Kurosawa.
J Stem Cells Regen Med, 2011 Jan 01; 7(1). PMID: 24693169    Free PMC article.
Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy.
Ming-Zhi Zhang, Yinqui Wang, Paisit Paueksakon, Raymond C Harris.
Diabetes, 2014 Apr 08; 63(6). PMID: 24705402    Free PMC article.
Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells.
Chih-Yen Tu, Chia-Hung Chen, +9 authors, Wei-Chien Huang.
Biomed Res Int, 2014 Apr 08; 2014. PMID: 24707474    Free PMC article.
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Kin K Leung, Ronald J Hause, +3 authors, Richard B Jones.
Mol Cell Proteomics, 2014 Apr 15; 13(7). PMID: 24728074    Free PMC article.
Design and applications of bispecific heterodimers: molecular imaging and beyond.
Haiming Luo, Hao Hong, Sarah P Yang, Weibo Cai.
Mol Pharm, 2014 Apr 18; 11(6). PMID: 24738564    Free PMC article.
Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies.
Virginia Shalkey Hahn, Daniel J Lenihan, Bonnie Ky.
J Am Heart Assoc, 2014 Apr 24; 3(2). PMID: 24755151    Free PMC article.
Highly Cited. Review.
Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.
Ichiro N Maruyama.
Cells, 2014 Apr 25; 3(2). PMID: 24758840    Free PMC article.
Meta-analysis of first-line therapies in advanced non-small-cell lung cancer harboring EGFR-activating mutations.
Benjamin Haaland, Pui San Tan, Gilberto de Castro, Gilberto Lopes.
J Thorac Oncol, 2014 May 03; 9(6). PMID: 24787964    Free PMC article.
Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer.
N Takahashi, Y Yamada, +6 authors, Y Shimada.
Br J Cancer, 2014 May 08; 110(11). PMID: 24800946    Free PMC article.
Current vaccine trials in glioblastoma: a review.
Linda W Xu, Kevin K H Chow, Michael Lim, Gordon Li.
J Immunol Res, 2014 May 08; 2014. PMID: 24804271    Free PMC article.
Identification of prolidase as a high affinity ligand of the ErbB2 receptor and its regulation of ErbB2 signaling and cell growth.
L Yang, Y Li, Y Zhang.
Cell Death Dis, 2014 May 09; 5. PMID: 24810047    Free PMC article.
Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies.
Simonetta M Leto, Livio Trusolino.
J Mol Med (Berl), 2014 May 09; 92(7). PMID: 24811491    Free PMC article.
Challenges in the Treatment of Triple Negative and HER2-Overexpressing Breast Cancer.
L Alexis Hoeferlin, Charles E Chalfant, Margaret A Park.
J Surg Sci, 2014 May 13; 1(1). PMID: 24818173    Free PMC article.
A dual tyrosine kinase inhibitor lapatinib suppresses overexpression of matrix metallopeptidase 1 (MMP1) in endometrial cancer.
Chiao-Yun Lin, Angel Chao, +8 authors, Chyong-Huey Lai.
J Mol Med (Berl), 2014 May 14; 92(9). PMID: 24820961
Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.
Jinming Gu, Jinsong Yang, +5 authors, Jijie Gu.
PLoS One, 2014 May 16; 9(5). PMID: 24824849    Free PMC article.
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer.
Beate C Litzenburger, Powel H Brown.
Curr Breast Cancer Rep, 2014 May 16; 6. PMID: 24829621    Free PMC article.
Targeted immunotherapy for non-small cell lung cancer.
Monali Vasekar, Xin Liu, Hong Zheng, Chandra P Belani.
World J Clin Oncol, 2014 May 16; 5(2). PMID: 24829850    Free PMC article.
Cancer stem cells and their mechanism of chemo-radiation resistance.
Yonghyun Kim, Kyeung Min Joo, Juyoun Jin, Do-Hyun Nam.
Int J Stem Cells, 2009 May 01; 2(2). PMID: 24855529    Free PMC article.
Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy.
Robert Torka, Kinga Pénzes, +5 authors, Axel Ullrich.
Neoplasia, 2014 May 28; 16(4). PMID: 24862757    Free PMC article.
Inhibition of EGFR, HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel: phase i study in Japanese patients with advanced solid malignancies and advanced breast cancer.
Takayasu Kurata, Junji Tsurutani, +6 authors, Kazuhiko Nakagawa.
Invest New Drugs, 2014 May 31; 32(5). PMID: 24875132
Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review.
Najla Fiaturi, John J Castellot, Heber C Nielsen.
J Cell Commun Signal, 2014 Jun 01; 8(2). PMID: 24878836    Free PMC article.
Targeted radionuclide therapy with A 177Lu-labeled anti-HER2 nanobody.
Matthias D'Huyvetter, Cécile Vincke, +8 authors, Tony Lahoutte.
Theranostics, 2014 Jun 03; 4(7). PMID: 24883121    Free PMC article.
Enhancement of gefitinib-induced growth inhibition by Marsdenia tenacissima extract in non-small cell lung cancer cells expressing wild or mutant EGFR.
Shu-Yan Han, Hui-Rong Ding, +2 authors, Ping-Ping Li.
BMC Complement Altern Med, 2014 Jun 03; 14. PMID: 24884778    Free PMC article.
Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab.
Jeonghee Cho, Adam J Bass, +23 authors, Matthew Meyerson.
Mol Cancer, 2014 Jun 05; 13. PMID: 24894453    Free PMC article.
Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies.
Yu Liu, Yun-Hong Ma, +7 authors, Ke-Jia Hu.
Tumour Biol, 2014 Jun 06; 35(9). PMID: 24899264
Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
Satoshi Sogabe, Youichi Kawakita, +7 authors, Tomoyasu Ishikawa.
ACS Med Chem Lett, 2013 Feb 14; 4(2). PMID: 24900643    Free PMC article.
Randomized phase Ib/II trial of rilotumumab or ganitumab with panitumumab versus panitumumab alone in patients with wild-type KRAS metastatic colorectal cancer.
Eric Van Cutsem, Cathy Eng, +16 authors, Josep Tabernero.
Clin Cancer Res, 2014 Jun 13; 20(16). PMID: 24919569    Free PMC article.
ERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells.
Jessica Tome-Garcia, Dan Li, +2 authors, Lizhao Wu.
PLoS One, 2014 Jun 18; 9(6). PMID: 24937171    Free PMC article.
Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas.
Mutlay Sayan, Arti Shukla, +7 authors, Brooke T Mossman.
Am J Respir Cell Mol Biol, 2014 Jun 19; 51(5). PMID: 24940987    Free PMC article.
PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.
Martina Sj McDermott, Brigid C Browne, +8 authors, Norma O'Donovan.
Mol Cancer, 2014 Jun 25; 13. PMID: 24958351    Free PMC article.
Comparison of HER2 status by fluorescence in situ hybridisation and immunohistochemistry in gastric cancer.
Ming Chen, Yan Li, +2 authors, Liu Xue Zheng.
Contemp Oncol (Pozn), 2014 Jun 27; 18(2). PMID: 24966791    Free PMC article.
ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells.
Hyunji Lee, Hyunjung Lee, +2 authors, Daekee Lee.
Oncotarget, 2014 Jun 28; 5(13). PMID: 24970817    Free PMC article.
Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib.
Michela de Martino, Dazhong Zhuang, +7 authors, Shahrokh F Shariat.
Cancer Biol Ther, 2014 Jun 28; 15(9). PMID: 24971884    Free PMC article.
Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours.
X Zhang, M A Blaskovich, K D Forinash, S M Sebti.
Br J Cancer, 2014 Jul 02; 111(5). PMID: 24983364    Free PMC article.
Regulation of EGFR nanocluster formation by ionic protein-lipid interaction.
Ye Wang, Jing Gao, +10 authors, Hongda Wang.
Cell Res, 2014 Jul 09; 24(8). PMID: 25001389    Free PMC article.
Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review).
Miho Iida, Kouji Banno, +9 authors, Daisuke Aoki.
Mol Clin Oncol, 2014 Jul 24; 2(5). PMID: 25054026    Free PMC article.
Personalized drug combinations to overcome trastuzumab resistance in HER2-positive breast cancer.
Thuy Vu, Mark X Sliwkowski, Francois X Claret.
Biochim Biophys Acta, 2014 Jul 30; 1846(2). PMID: 25065528    Free PMC article.
Screening and identification of small molecule inhibitors of ErbB2-induced invasion.
D M Brix, B Rafn, +4 authors, T Kallunki.
Mol Oncol, 2014 Jul 30; 8(8). PMID: 25070180    Free PMC article.
The prognostic value of HER-2/neu overexpression in colorectal cancer: evidence from 16 studies.
Sheng-Wen Wu, Cong-Chao Ma, Yu Yang.
Tumour Biol, 2014 Aug 01; 35(11). PMID: 25077923
Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.
Jennifer L Macdonald-Obermann, Linda J Pike.
J Biol Chem, 2014 Aug 03; 289(38). PMID: 25086039    Free PMC article.
Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab.
Toru Kawamoto, Kazunori Ishige, +7 authors, Junichi Shoda.
J Gastroenterol, 2014 Aug 13; 50(4). PMID: 25112701
Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation.
Kei-ichiro Arimoto, Christoph Burkart, +3 authors, Dong-Er Zhang.
Mol Cell Biol, 2014 Aug 13; 34(20). PMID: 25113560    Free PMC article.
Therapeutic potential of siRNA and DNAzymes in cancer.
Hanuma Kumar Karnati, Ravi Shekar Yalagala, +2 authors, Ravi Kumar Gutti.
Tumour Biol, 2014 Aug 26; 35(10). PMID: 25149153
Clinicopathological features and EGFR gene mutation status in elderly patients with resected non-small-cell lung cancer.
Teppei Nishii, Tomoyuki Yokose, +13 authors, Munetaka Masuda.
BMC Cancer, 2014 Aug 26; 14. PMID: 25152277    Free PMC article.
YAC tripeptide of epidermal growth factor promotes the proliferation of HaCaT keratinocytes through activation of EGFR.
Yeon Ho Yoo, Yu Ri Kim, +3 authors, Jang-Hee Hahn.
BMB Rep, 2014 Sep 03; 47(10). PMID: 25179402    Free PMC article.
EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.
Yvonne Möller, Martin Siegemund, +7 authors, Monilola A Olayioye.
PLoS One, 2014 Sep 10; 9(9). PMID: 25198428    Free PMC article.
Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.
Gloria Reyes, Matt Niederst, +10 authors, Alexandra C Newton.
Proc Natl Acad Sci U S A, 2014 Sep 10; 111(38). PMID: 25201979    Free PMC article.
Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC.
Rania Gaber, Iris Watermann, +6 authors, Torsten Goldmann.
Diagn Pathol, 2014 Sep 18; 9. PMID: 25227424    Free PMC article.
Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma.
M Campos, M M J Kool, +5 authors, J A Mol.
J Vet Intern Med, 2014 Sep 19; 28(6). PMID: 25231196    Free PMC article.
EGFR-TKI resistance in NSCLC patients: mechanisms and strategies.
Yuxin Lin, Xian Wang, Hongchuan Jin.
Am J Cancer Res, 2014 Sep 19; 4(5). PMID: 25232485    Free PMC article.
Highly Cited. Review.
Anticancer effects of different seaweeds on human colon and breast cancers.
Ghislain Moussavou, Dong Hoon Kwak, +7 authors, Young Kug Choo.
Mar Drugs, 2014 Sep 26; 12(9). PMID: 25255129    Free PMC article.
Pharmacological targeting of the pseudokinase Her3.
Ting Xie, Sang Min Lim, +12 authors, Nathanael S Gray.
Nat Chem Biol, 2014 Oct 20; 10(12). PMID: 25326665    Free PMC article.
The significance of genetics for cholangiocarcinoma development.
Luca Maroni, Irene Pierantonelli, +2 authors, Marco Marzioni.
Ann Transl Med, 2014 Oct 22; 1(3). PMID: 25332972    Free PMC article.
Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems.
W Sangrar, C Shi, +3 authors, P A Greer.
Oncogene, 2014 Oct 28; 34(31). PMID: 25347743
Soluble LRIG2 ectodomain is released from glioblastoma cells and promotes the proliferation and inhibits the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2.
Qungen Xiao, Yihu Tan, +6 authors, Dongsheng Guo.
PLoS One, 2014 Oct 30; 9(10). PMID: 25353163    Free PMC article.
Clinical management of advanced gastric cancer: the role of new molecular drugs.
Ferdinando De Vita, Natale Di Martino, +11 authors, Michele Orditura.
World J Gastroenterol, 2014 Oct 31; 20(40). PMID: 25356019    Free PMC article.
Functional aspects of the EGF-induced MAP kinase cascade: a complex self-organizing system approach.
Efstratios K Kosmidis, Vasiliki Moschou, +3 authors, Nikolaos A Laskaris.
PLoS One, 2014 Nov 06; 9(11). PMID: 25372488    Free PMC article.
Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.
Kurt Schönfeld, Christiane Sahm, +19 authors, Winfried S Wels.
Mol Ther, 2014 Nov 07; 23(2). PMID: 25373520    Free PMC article.
Highly Cited.
Skin/nail infections with the addition of pertuzumab to trastuzumab-based chemotherapy.
Joanne Mortimer, Jae Jung, +8 authors, Sanjeet Dadwal.
Breast Cancer Res Treat, 2014 Nov 12; 148(3). PMID: 25385180    Free PMC article.
Regulation of ERBB3/HER3 signaling in cancer.
Kalpana Mujoo, Byung-Kwon Choi, +2 authors, Zhiqiang An.
Oncotarget, 2014 Nov 18; 5(21). PMID: 25400118    Free PMC article.
A positive role of DBC1 in PEA3-mediated progression of estrogen receptor-negative breast cancer.
H J Kim, S-H Kim, +2 authors, J H Kim.
Oncogene, 2014 Nov 25; 34(34). PMID: 25417701
Epigenetics in breast and prostate cancer.
Yanyuan Wu, Marianna Sarkissyan, Jaydutt V Vadgama.
Methods Mol Biol, 2014 Nov 26; 1238. PMID: 25421674    Free PMC article.
HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.
Delphine R Boulbes, Stefan T Arold, +13 authors, Francisco J Esteva.
Mol Oncol, 2014 Dec 02; 9(3). PMID: 25435280    Free PMC article.
Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.
Lakshmi Reddy Bollu, Jiangong Ren, +6 authors, Zhang Weihua.
Cell Cycle, 2014 Dec 09; 13(15). PMID: 25483192    Free PMC article.
Amelioration of hypercholesterolemia by an EGFR tyrosine kinase inhibitor in mice with liver-specific knockout of Mig-6.
Jun Choul Lee, Byung Kil Park, +8 authors, Bon Jeong Ku.
PLoS One, 2014 Dec 09; 9(12). PMID: 25486251    Free PMC article.
Efficacy of EGFR tyrosine kinase inhibitors in non-small-cell lung cancer patients with/without EGFR-mutation: evidence based on recent phase III randomized trials.
Wen-Qian Zhang, Tong Li, Hui Li.
Med Sci Monit, 2014 Dec 17; 20. PMID: 25503781    Free PMC article.
EGF and EGFR genetic polymorphisms predict prognosis in locally advanced pharyngolaryngeal squamous cell carcinoma patients receiving postoperative concurrent chemoradiotherapy.
Nai-Wen Su, Yi-Shing Leu, +8 authors, Yi-Fang Chang.
Onco Targets Ther, 2014 Dec 17; 7. PMID: 25506224    Free PMC article.
The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.
Joseline Ratnam, Barbara Zdrazil, +15 authors, Christine Chichester.
PLoS One, 2014 Dec 19; 9(12). PMID: 25522365    Free PMC article.
Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells.
Stephanie Verbeke, Elodie Richard, +7 authors, Richard D Iggo.
Breast Cancer Res, 2014 Dec 21; 16(6). PMID: 25527189    Free PMC article.
A peptide antigen derived from EGFR T790M is immunogenic in non‑small cell lung cancer.
Kazuya Ofuji, Yoshitaka Tada, +5 authors, Tetsuya Nakatsura.
Int J Oncol, 2014 Dec 23; 46(2). PMID: 25532027    Free PMC article.
ErbB4 as a potential molecular target in the treatment of esophageal squamous cell cancers.
Ke Zhao, Bao-Jun Chen, Zhi-Guo Chen.
ScientificWorldJournal, 2014 Dec 30; 2014. PMID: 25538945    Free PMC article.
Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells.
Philippe Nizard, Frédéric Ezan, +5 authors, Nathalie Théret.
BMC Genomics, 2014 Dec 30; 15. PMID: 25540073    Free PMC article.
Afatinib efficacy against squamous cell carcinoma of the head and neck cell lines in vitro and in vivo.
Natalie R Young, Christian Soneru, +6 authors, Ezra E W Cohen.
Target Oncol, 2015 Jan 07; 10(4). PMID: 25559287    Free PMC article.
Epidermal Growth Factor Receptor Expression in Spindle Cell Carcinomas of the Head and Neck.
R F Watson, R D Chernock, +4 authors, J S Lewis.
Head Neck Pathol, 2015 Jan 08; 9(3). PMID: 25563452    Free PMC article.
Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer.
Andrew T Baker, Andrei Zlobin, Clodia Osipo.
Front Oncol, 2015 Jan 08; 4. PMID: 25566499    Free PMC article.
Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity.
Roshan Sriram, Vivian Lo, +7 authors, Luc A Sabourin.
Breast Cancer Res, 2015 Jan 17; 17. PMID: 25592291    Free PMC article.
Pathways driving the endocytosis of mutant and wild-type EGFR in cancer.
Kaia K Hampton, Rolf J Craven.
Oncoscience, 2015 Jan 17; 1(8). PMID: 25594057    Free PMC article.
BCL2 is an independent predictor of outcome in basal-like triple-negative breast cancers treated with adjuvant anthracycline-based chemotherapy.
Katerina Bouchalova, Marek Svoboda, +8 authors, Zdenek Kolar.
Tumour Biol, 2015 Jan 27; 36(6). PMID: 25616695
Extracellular molecules involved in cancer cell invasion.
Theodora Stivarou, Evangelia Patsavoudi.
Cancers (Basel), 2015 Jan 30; 7(1). PMID: 25629807    Free PMC article.
Ten things you should know about protein kinases: IUPHAR Review 14.
Doriano Fabbro, Sandra W Cowan-Jacob, Henrik Moebitz.
Br J Pharmacol, 2015 Jan 30; 172(11). PMID: 25630872    Free PMC article.
Ets1 identified as a novel molecular target of RNA aptamer selected against metastatic cells for targeted delivery of nano-formulation.
J Kaur, K Tikoo.
Oncogene, 2015 Feb 03; 34(41). PMID: 25639877    Free PMC article.
Unraveling the molecular genetics of head and neck cancer through genome-wide approaches.
Nadeem Riaz, Luc G Morris, William Lee, Timothy A Chan.
Genes Dis, 2015 Feb 03; 1(1). PMID: 25642447    Free PMC article.
Dacomitinib (PF-00299804), a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor, demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro.
Liancheng Zhu, Salvatore Lopez, +15 authors, Alessandro D Santin.
Tumour Biol, 2015 Feb 12; 36(7). PMID: 25669172    Free PMC article.
Jennifer L Woodring, Gautam Patel, +7 authors, Michael P Pollastri.
Medchemcomm, 2015 Feb 17; 6(2). PMID: 25685309    Free PMC article.
Preclinical pharmacokinetics, pharmacodynamics, and efficacy of RG7116: a novel humanized, glycoengineered anti-HER3 antibody.
Georgina Meneses-Lorente, Thomas Friess, +5 authors, Birgit Bossenmaier.
Cancer Chemother Pharmacol, 2015 Feb 24; 75(4). PMID: 25702049    Free PMC article.
Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluorescence in situ hybridization impact on prognosis in breast cancer.
Jiao Li, Wei Su, +10 authors, Jin Zhang.
Cancer Sci, 2015 Feb 24; 106(5). PMID: 25702787    Free PMC article.
EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.
Nai Yang Fu, Anne C Rios, +12 authors, Jane E Visvader.
Nat Cell Biol, 2015 Mar 03; 17(4). PMID: 25730472
Computational modeling of drug response with applications to neuroscience.
Ralf Herwig.
Dialogues Clin Neurosci, 2015 Mar 04; 16(4). PMID: 25733952    Free PMC article.
Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.
Linxiang Lan, Jane D Holland, +6 authors, Walter Birchmeier.
EMBO J, 2015 Mar 05; 34(11). PMID: 25736378    Free PMC article.
HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value.
An Na Seo, Yoonjin Kwak, +4 authors, Hye Seung Lee.
Virchows Arch, 2015 Mar 06; 466(6). PMID: 25739551
An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
G Zhu, Z Fan, +8 authors, W Wu.
Oncogene, 2015 Mar 10; 34(49). PMID: 25746002
Cancer stratification by molecular imaging.
Justus Weber, Uwe Haberkorn, Walter Mier.
Int J Mol Sci, 2015 Mar 10; 16(3). PMID: 25749472    Free PMC article.
Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer.
Igor F Tsigelny, Jennifer J Wheler, +4 authors, Razelle Kurzrock.
Oncotarget, 2015 Mar 12; 6(8). PMID: 25760241    Free PMC article.
Antitumor Activity of HM781-36B, alone or in Combination with Chemotherapeutic Agents, in Colorectal Cancer Cells.
Mi Hyun Kang, Sung Ung Moon, +5 authors, Jee Hyun Kim.
Cancer Res Treat, 2015 Mar 13; 48(1). PMID: 25761479    Free PMC article.
A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.
B Chu, F Liu, +7 authors, Y Jiang.
Cell Death Dis, 2015 Mar 15; 6. PMID: 25766325    Free PMC article.
Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.
Wies van Roosmalen, Sylvia E Le Dévédec, +15 authors, Bob van de Water.
J Clin Invest, 2015 Mar 17; 125(4). PMID: 25774502    Free PMC article.
Highly Cited.
Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics.
Zeenat Mirza, Hans-Juergen Schulten, +6 authors, Sajjad Karim.
PLoS One, 2015 Mar 20; 10(3). PMID: 25789858    Free PMC article.
Em08red, a dual functional antiproliferative emodin analogue, is a downregulator of ErbB2 expression and inducer of intracellular oxidative stress.
Fong-Pin Liang, Jin-Cherng Lien, +2 authors, Shin-Hun Juang.
Drug Des Devel Ther, 2015 Mar 21; 9. PMID: 25792810    Free PMC article.
The application of click chemistry in the synthesis of agents with anticancer activity.
Nan Ma, Ying Wang, +2 authors, Sheng Jiang.
Drug Des Devel Ther, 2015 Mar 21; 9. PMID: 25792812    Free PMC article.
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression.
C He, X Lv, +5 authors, C Wang.
Oncogene, 2015 Mar 24; 34(50). PMID: 25798835    Free PMC article.
A Paracrine Mechanism Accelerating Expansion of Human Induced Pluripotent Stem Cell-Derived Hepatic Progenitor-Like Cells.
Kota Tsuruya, Hiromi Chikada, +5 authors, Akihide Kamiya.
Stem Cells Dev, 2015 Mar 27; 24(14). PMID: 25808356    Free PMC article.
Endothelial PAS domain-containing protein 1 confers TKI-resistance by mediating EGFR and MET pathways in non-small cell lung cancer cells.
Qiang Zhen, Jun-Feng Liu, +6 authors, Bao-Lei Lv.
Cancer Biol Ther, 2015 Apr 02; 16(4). PMID: 25831463    Free PMC article.
A paradigm shift: Cancer therapy with peptide-based B-cell epitopes and peptide immunotherapeutics targeting multiple solid tumor types: Emerging concepts and validation of combination immunotherapy.
Pravin T P Kaumaya.
Hum Vaccin Immunother, 2015 Apr 16; 11(6). PMID: 25874884    Free PMC article.
EPMA position paper in cancer: current overview and future perspectives.
Godfrey Grech, Xianquan Zhan, +5 authors, Dominic M Desiderio.
EPMA J, 2015 Apr 25; 6(1). PMID: 25908947    Free PMC article.
Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis.
Sidra Younis, Qamar Javed, Miroslav Blumenberg.
BMC Cancer, 2015 May 08; 15. PMID: 25948104    Free PMC article.
Anti-HER3 monoclonal antibody patritumab sensitizes refractory non-small cell lung cancer to the epidermal growth factor receptor inhibitor erlotinib.
K Yonesaka, K Hirotani, +7 authors, K Nakagawa.
Oncogene, 2015 May 12; 35(7). PMID: 25961915
Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer.
Jing Shi, Wei Liu, +6 authors, Peng Hou.
Oncotarget, 2015 May 15; 6(16). PMID: 25970779    Free PMC article.
ROS1 amplification mediates resistance to gefitinib in glioblastoma cells.
Hashim Aljohani, Robert F Koncar, +3 authors, El Mustapha Bahassi.
Oncotarget, 2015 May 16; 6(24). PMID: 25978031    Free PMC article.
Contribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma Treatments.
Debby D Wang, Lichun Ma, +2 authors, Hong Yan.
PLoS One, 2015 May 21; 10(5). PMID: 25993617    Free PMC article.
Plakophilin-2 induced EGFR phosphorylation: a focus on the intracellular activators of EGFR.
Kei-Ichiro Arimoto, Stephanie Weng, Dong-Er Zhang.
Receptors Clin Investig, 2014 Jan 01; 2(1). PMID: 25995992    Free PMC article.
Identification of Anti-EGFR and Anti-ErbB3 Dual Variable Domains Immunoglobulin (DVD-Ig) Proteins with Unique Activities.
Jinming Gu, Jinsong Yang, +3 authors, Jijie Gu.
PLoS One, 2015 May 23; 10(5). PMID: 25997020    Free PMC article.
From bench to bedside: What do we know about hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer?
Victoria Shang Wu, Noriko Kanaya, +2 authors, Shiuan Chen.
J Steroid Biochem Mol Biol, 2015 May 23; 153. PMID: 25998416    Free PMC article.
PI3K mutations in breast cancer: prognostic and therapeutic implications.
Toru Mukohara.
Breast Cancer (Dove Med Press), 2015 Jun 02; 7. PMID: 26028978    Free PMC article.
Highly Cited. Review.
Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells.
Imayavaramban Lakshmanan, Parthasarathy Seshacharyulu, +9 authors, Surinder K Batra.
Oncotarget, 2015 Jun 03; 6(25). PMID: 26035354    Free PMC article.
Sulforaphane attenuates EGFR signaling in NSCLC cells.
Chi-Yuan Chen, Zhu-Yun Yu, +2 authors, Tzu-Chien V Wang.
J Biomed Sci, 2015 Jun 04; 22. PMID: 26036303    Free PMC article.
Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER).
Shao Ma, Ning Yin, +4 authors, Guan Chen.
Oncotarget, 2015 Jun 17; 6(15). PMID: 26079946    Free PMC article.
Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant.
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang.
EBioMedicine, 2015 Jun 19; 2(5). PMID: 26086037    Free PMC article.
Development of small molecules targeting the pseudokinase Her3.
Sang Min Lim, Ting Xie, +8 authors, Nathanael S Gray.
Bioorg Med Chem Lett, 2015 Jun 22; 25(16). PMID: 26094118    Free PMC article.
Co-modulation analysis of gene regulation in breast cancer reveals complex interplay between ESR1 and ERBB2 genes.
Yu-Chiao Chiu, Chin-Ting Wu, +4 authors, Eric Y Chuang.
BMC Genomics, 2015 Jun 24; 16 Suppl 7. PMID: 26100352    Free PMC article.
Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma.
L H McCormick Matthews, F Noble, +6 authors, T J Underwood.
Br J Cancer, 2015 Jun 26; 113(1). PMID: 26110972    Free PMC article.
Systematic Review.
Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival.
Subhasis Das, Gautam Sondarva, +5 authors, Ajay Rana.
J Biol Chem, 2015 Jul 15; 290(35). PMID: 26152725    Free PMC article.
Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection.
Rosalinda Madonna, Christian Cadeddu, +9 authors, Giuseppe Mercuro.
Heart Fail Rev, 2015 Jul 15; 20(5). PMID: 26168714
The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors.
Eric Haines, Sabrina Schlienger, Audrey Claing.
Cancer Biol Ther, 2015 Jul 16; 16(10). PMID: 26176330    Free PMC article.
Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival.
Mariya Farooqui, Laura R Bohrer, +5 authors, Kathryn L Schwertfeger.
Mol Cancer, 2015 Jul 29; 14. PMID: 26215578    Free PMC article.
Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier.
Ryuta Kamekura, Porfirio Nava, +5 authors, Asma Nusrat.
Mol Biol Cell, 2015 Aug 01; 26(18). PMID: 26224314    Free PMC article.
Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.
Ruth Rodriguez-Barrueco, Jiyang Yu, +13 authors, Jose M Silva.
Genes Dev, 2015 Aug 01; 29(15). PMID: 26227964    Free PMC article.
A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis.
Kin-Mei Leung, Sarah Batey, +16 authors, Haijun Sun.
Mol Ther, 2015 Aug 04; 23(11). PMID: 26234505    Free PMC article.
ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.
Frances Belmonte, Samarjit Das, +9 authors, Kathleen Gabrielson.
Am J Physiol Heart Circ Physiol, 2015 Aug 09; 309(8). PMID: 26254336    Free PMC article.
The epidermal growth factor receptor (EGFR / HER-1) gatekeeper mutation T790M is present in European patients with early breast cancer.
Vahid Bemanian, Torill Sauer, +6 authors, Jürgen Geisler.
PLoS One, 2015 Aug 13; 10(8). PMID: 26267891    Free PMC article.
Does overexpression of HER-2 correlate with clinicopathological characteristics and prognosis in colorectal cancer? Evidence from a meta-analysis.
Sheng-wen Wu, Cong-chao Ma, Wen-hui Li.
Diagn Pathol, 2015 Aug 16; 10. PMID: 26276145    Free PMC article.
Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma.
Paula González-Alonso, Cristina Chamizo, +9 authors, Federico Rojo.
Int J Mol Sci, 2015 Aug 20; 16(8). PMID: 26287187    Free PMC article.
HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma.
Feifei Chen, Junpeng Deng, +2 authors, Junnian Zheng.
Sci Rep, 2015 Aug 26; 5. PMID: 26304749    Free PMC article.
New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?
Giuseppe Bronte, Nicola Silvestris, +10 authors, Antonio Russo.
Oncotarget, 2015 Sep 01; 6(28). PMID: 26318427    Free PMC article.
Cancer targeted therapeutics: From molecules to drug delivery vehicles.
Daxing Liu, Debra T Auguste.
J Control Release, 2015 Sep 08; 219. PMID: 26342659    Free PMC article.
Anti-Tumor Effects of Peptide Therapeutic and Peptide Vaccine Antibody Co-targeting HER-1 and HER-2 in Esophageal Cancer (EC) and HER-1 and IGF-1R in Triple-Negative Breast Cancer (TNBC).
Jay Overholser, Kristen Henkins Ambegaokar, +4 authors, Pravin T P Kaumaya.
Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350593    Free PMC article.
The distinctive nature of adenocarcinoma of the lung.
Giandomenico Roviello.
Onco Targets Ther, 2015 Sep 15; 8. PMID: 26366094    Free PMC article.
ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer.
Thierry Jardé, Lisa Kass, +5 authors, Helen E Abud.
PLoS One, 2015 Sep 15; 10(9). PMID: 26367378    Free PMC article.
Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation.
Lakshmi Reddy Bollu, Rajashekhara Reddy Katreddy, +4 authors, Zhang Weihua.
Oncotarget, 2015 Sep 18; 6(33). PMID: 26378037    Free PMC article.
Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology.
Dan Shu, Hui Li, +5 authors, Peixuan Guo.
ACS Nano, 2015 Sep 22; 9(10). PMID: 26387848    Free PMC article.
Highly Cited.
Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2.
Yifen Wu, Rong Li, +5 authors, Rongcheng Luo.
Onco Targets Ther, 2015 Sep 24; 8. PMID: 26396531    Free PMC article.
Role of HER2 mutations in refractory metastatic breast cancers: targeted sequencing results in patients with refractory breast cancer.
Yeon Hee Park, Hyun-Tae Shin, +9 authors, Young-Hyuck Im.
Oncotarget, 2015 Sep 24; 6(31). PMID: 26397225    Free PMC article.
The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer.
Kimio Yonesaka, Keita Kudo, +9 authors, Kazuhiko Nakagawa.
Oncotarget, 2015 Sep 30; 6(32). PMID: 26418897    Free PMC article.
Low EGFR/MET ratio is associated with resistance to EGFR inhibitors in non-small cell lung cancer.
Silvia Park, Emma Langley, +7 authors, Myung-Ju Ahn.
Oncotarget, 2015 Oct 07; 6(31). PMID: 26439803    Free PMC article.
Targeting HER2 Positive Breast Cancer with Chemopreventive Agents.
Joseph Wahler, Nanjoo Suh.
Curr Pharmacol Rep, 2015 Oct 07; 1(5). PMID: 26442201    Free PMC article.
Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.
Xiangyou Hu, Qingyuan Fan, Hailong Hou, Riqiang Yan.
J Neurochem, 2015 Oct 16; 136(2). PMID: 26465092    Free PMC article.
[Role of HER2 in NSCLC].
Kun Zhang, Hong Wang.
Zhongguo Fei Ai Za Zhi, 2015 Oct 21; 18(10). PMID: 26483338    Free PMC article.
Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.
Qinglei Hang, Tomoya Isaji, +3 authors, Jianguo Gu.
J Biol Chem, 2015 Oct 21; 290(49). PMID: 26483551    Free PMC article.
Tunicamycin enhances the antitumor activity of trastuzumab on breast cancer in vitro and in vivo.
Xiqian Han, Xiaobing Zhang, +4 authors, Yikang Shi.
Oncotarget, 2015 Oct 27; 6(36). PMID: 26498681    Free PMC article.
Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.
Y-C Yang, T-Y Cheng, +7 authors, M-L Kuo.
Oncogene, 2015 Oct 27; 35(26). PMID: 26500058
PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.
Q Wang, P Liu, +6 authors, J J Zhao.
Oncogene, 2015 Oct 27; 35(27). PMID: 26500061    Free PMC article.
HER3 over-expression and overall survival in gastrointestinal cancers.
Yadong Wang, Haiyan Yang, Guangcai Duan.
Oncotarget, 2015 Oct 31; 6(40). PMID: 26517355    Free PMC article.
Monoclonal antibodies-based treatment in gastric cancer: current status and future perspectives.
Giandomenico Roviello, Karol Polom, +8 authors, Franco Roviello.
Tumour Biol, 2015 Nov 15; 37(1). PMID: 26566626
Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer.
Kimio Yonesaka, Naoki Takegawa, +9 authors, Kazuhiko Nakagawa.
PLoS One, 2015 Nov 17; 10(11). PMID: 26569500    Free PMC article.
Immuno-PET Imaging of HER3 in a Model in which HER3 Signaling Plays a Critical Role.
Qinghua Yuan, Takako Furukawa, +12 authors, Tsuneo Saga.
PLoS One, 2015 Nov 17; 10(11). PMID: 26571416    Free PMC article.
Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer.
Caifeng Xie, Jiangbo Jin, +5 authors, Jianbin Wang.
Oncotarget, 2015 Nov 18; 7(1). PMID: 26575584    Free PMC article.
Generation of new peptide-Fc fusion proteins that mediate antibody-dependent cellular cytotoxicity against different types of cancer cells.
Mouldy Sioud, Phuong Westby, Julie Kristine E Olsen, Anne Mobergslien.
Mol Ther Methods Clin Dev, 2015 Nov 26; 2. PMID: 26605373    Free PMC article.
Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES.
Yuji Kado, Eiichi Mizohata, +15 authors, Tsuyoshi Inoue.
J Biol Chem, 2015 Dec 03; 291(5). PMID: 26627827    Free PMC article.
Γ-Ionizing radiation-induced activation of the EGFR-p38/ERK-STAT3/CREB-1-EMT pathway promotes the migration/invasion of non-small cell lung cancer cells and is inhibited by podophyllotoxin acetate.
Jeong Hyun Cho, Wan Gi Hong, +5 authors, Jong Kuk Park.
Tumour Biol, 2015 Dec 17; 37(6). PMID: 26671552
Gastric Cancer: New Drugs - New Strategies.
Nadin Schulte, Matthias P Ebert, Nicola Härtel.
Gastrointest Tumors, 2014 May 01; 1(4). PMID: 26674336    Free PMC article.
Genetic variants in ERBB4 is associated with chronic hepatitis B virus infection.
Yao Liu, Qun Zhou, +9 authors, Jian-Ming Li.
Oncotarget, 2015 Dec 25; 7(4). PMID: 26701850    Free PMC article.
EGFR and HER2 signaling in breast cancer brain metastasis.
Sherona R Sirkisoon, Richard L Carpenter, +3 authors, Hui-Wen Lo.
Front Biosci (Elite Ed), 2015 Dec 29; 8. PMID: 26709660    Free PMC article.
Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer.
Valeria Santoro, Ruochen Jia, +6 authors, Daniel Hochhauser.
J Natl Cancer Inst, 2016 Jan 01; 108(6). PMID: 26719345    Free PMC article.
Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment.
Jill W Ivey, Mohammad Bonakdar, +2 authors, Scott S Verbridge.
Cancer Lett, 2016 Jan 03; 380(1). PMID: 26724680    Free PMC article.
Overexpression of HER-2 in MDA-MB-435/LCC6 Tumours is Associated with Higher Metabolic Activity and Lower Energy Stress.
Wieslawa H Dragowska, Mihaela Ginj, +6 authors, Donald T T Yapp.
Sci Rep, 2016 Jan 05; 6. PMID: 26727049    Free PMC article.
EGFR Signaling in Liver Diseases.
Karin Komposch, Maria Sibilia.
Int J Mol Sci, 2016 Jan 06; 17(1). PMID: 26729094    Free PMC article.
Highly Cited. Review.
Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.
Sebastian K Wandinger, Idoya Lahortiga, +9 authors, Henrik Daub.
PLoS One, 2016 Jan 09; 11(1). PMID: 26745281    Free PMC article.
Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential.
Gregory T Wurz, Chiao-Jung Kao, Michael W DeGregorio.
Ther Adv Med Oncol, 2016 Jan 12; 8(1). PMID: 26753003    Free PMC article.
Epidermal growth factor receptor targeting and challenges in glioblastoma.
Amy Haseley Thorne, Ciro Zanca, Frank Furnari.
Neuro Oncol, 2016 Jan 13; 18(7). PMID: 26755074    Free PMC article.
Highly Cited. Review.
Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer.
Raju Dash, Mir Muhammad Nasir Uddin, +6 authors, Md Kamrul Hossain.
Bioinformation, 2016 Jan 16; 11(12). PMID: 26770028    Free PMC article.
Profile of panitumumab as first-line treatment in patients with wild-type KRAS metastatic colorectal cancer.
Shiven B Patel, David Gill, Ignacio Garrido-Laguna.
Onco Targets Ther, 2016 Jan 16; 9. PMID: 26770060    Free PMC article.
Inhibition of LN-308 glioma cell proliferation and migration by retinoic acid amide through activation of Akt pathway.
Jun Zhu, Xiang-Dong Lu, +2 authors, Qing-Hai Meng.
Int J Clin Exp Pathol, 2016 Jan 30; 8(11). PMID: 26823704    Free PMC article.
EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma.
Hsuan-Yu Chen, Chia-Hsin Liu, +14 authors, Pan-Chyr Yang.
Oncotarget, 2016 Jan 30; 7(8). PMID: 26824984    Free PMC article.
Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells.
Stephanie N Shishido, Thu A Nguyen.
Int J Mol Sci, 2016 Feb 04; 17(2). PMID: 26840298    Free PMC article.
Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma.
Charlotta Hedner, David Borg, +3 authors, Jakob Eberhard.
PLoS One, 2016 Feb 06; 11(2). PMID: 26844548    Free PMC article.
Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer.
Joanna M Poczobutt, Subhajyoti De, +5 authors, Raphael A Nemenoff.
J Immunol, 2016 Feb 14; 196(6). PMID: 26873985    Free PMC article.
Advances of Molecular Targeted Therapy in Gastric Cancer.
Bulent Cetin, Ozge Gumusay, Mustafa Cengiz, Ahmet Ozet.
J Gastrointest Cancer, 2016 Feb 15; 47(2). PMID: 26875080
Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway.
L Fabris, S Berton, +17 authors, B Belletti.
Oncogene, 2016 Feb 16; 35(37). PMID: 26876200    Free PMC article.
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells.
Chen-Ying Liu, Siew Wee Chan, +3 authors, Wanjin Hong.
Oncotarget, 2016 Feb 18; 7(12). PMID: 26885614    Free PMC article.
Phase II study on the efficacy and safety of Lapatinib administered beyond disease progression and combined with vinorelbine in HER-2/neu- positive advanced breast cancer: results of the CECOG LaVie trial.
Christiane Thallinger, Istvan Lang, +7 authors, Christoph Zielinski.
BMC Cancer, 2016 Feb 19; 16. PMID: 26887956    Free PMC article.
Prognostic value of ERBB4 expression in patients with triple negative breast cancer.
Ji-Yeon Kim, Hae Hyun Jung, +8 authors, Young-Hyuck Im.
BMC Cancer, 2016 Feb 26; 16. PMID: 26907936    Free PMC article.
Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma.
Maria J De Herdt, Stefan M Willems, +7 authors, Leendert H J Looijenga.
Oncotarget, 2016 Feb 26; 7(11). PMID: 26909606    Free PMC article.
Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications.
Muhammad Hasan Bashari, Fengjuan Fan, +11 authors, Klaus Podar.
Breast Cancer Res, 2016 Feb 28; 18(1). PMID: 26921175    Free PMC article.
APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.
Se-Hoon Hong, Won Jae Lee, +10 authors, Yong-Keun Jung.
Oncotarget, 2016 Mar 05; 7(16). PMID: 26942872    Free PMC article.
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk.
Yvonne E Smith, Sri HariKrishna Vellanki, Ann M Hopkins.
World J Biol Chem, 2016 Mar 17; 7(1). PMID: 26981196    Free PMC article.
GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.
Xiumei Sheng, Nathan Bowen, Zhengxin Wang.
Mol Cancer, 2016 Mar 19; 15. PMID: 26988096    Free PMC article.
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
Yuan Lu, Yuan Wang, +11 authors, Xinling Ren.
Oncotarget, 2016 Mar 19; 7(17). PMID: 26988752    Free PMC article.
A monoclonal antibody targeting ErbB2 domain III inhibits ErbB2 signaling and suppresses the growth of ErbB2-overexpressing breast tumors.
Y Meng, L Zheng, +10 authors, B Li.
Oncogenesis, 2016 Mar 22; 5. PMID: 26999718    Free PMC article.
Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression.
Chuu-Yun A Wong, Haihong Jiang, +4 authors, Yaping Tu.
Protein Cell, 2016 Mar 30; 7(6). PMID: 27020455    Free PMC article.
Recent developments in receptor tyrosine kinases targeted anticancer therapy.
Samir H Raval, Ratn D Singh, +2 authors, Shailesh K Mody.
Vet World, 2016 Apr 07; 9(1). PMID: 27051190    Free PMC article.
The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer.
Elisabeth Hofmann, Rita Seeboeck, +7 authors, Andreas Eger.
Biomark Res, 2016 Apr 09; 4. PMID: 27057311    Free PMC article.
Tumor-suppressive miR-218-5p inhibits cancer cell proliferation and migration via EGFR in non-small cell lung cancer.
Kegan Zhu, Hanying Ding, +6 authors, Xi Chen.
Oncotarget, 2016 Apr 09; 7(19). PMID: 27057632    Free PMC article.
HER2 Expression in Gastric Adenocarcinoma-a Study in a Tertiary Care Centre in South India.
Raj Aditi, Rau Aarathi, +3 authors, Kumar Amar.
Indian J Surg Oncol, 2016 Apr 12; 7(1). PMID: 27065677    Free PMC article.
Neuregulin expression in solid tumors: prognostic value and predictive role to anti-HER3 therapies.
Alberto Ocaña, Laura Díez-González, +3 authors, Atanasio Pandiella.
Oncotarget, 2016 Apr 14; 7(29). PMID: 27074567    Free PMC article.
Loquat (Eriobotrya japonica) leaf extract inhibits the growth of MDA-MB-231 tumors in nude mouse xenografts and invasion of MDA-MB-231 cells.
Mi-Kyoung You, Min-Sook Kim, +3 authors, Hyeon-A Kim.
Nutr Res Pract, 2016 Apr 19; 10(2). PMID: 27087896    Free PMC article.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
Susanne Scheipl, Michelle Barnard, +16 authors, Adrienne M Flanagan.
J Pathol, 2016 Apr 23; 239(3). PMID: 27102572    Free PMC article.
Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical Relevance.
Sally Maramotti, Massimiliano Paci, +5 authors, Filippo Lococo.
Int J Mol Sci, 2016 Apr 23; 17(4). PMID: 27104520    Free PMC article.
Combined assessment of EGFR-related molecules to predict outcome of 1st-line cetuximab-containing chemotherapy for metastatic colorectal cancer.
Yu Sunakawa, Dongyun Yang, +18 authors, Heinz-Josef Lenz.
Cancer Biol Ther, 2016 Apr 23; 17(7). PMID: 27104867    Free PMC article.
Molecularly targeted therapy for the treatment of head and neck cancer: a review of the ErbB family inhibitors.
Assuntina G Sacco, Francis P Worden.
Onco Targets Ther, 2016 Apr 26; 9. PMID: 27110122    Free PMC article.
Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma.
Megan L Ludwig, Andrew C Birkeland, +3 authors, J Chad Brenner.
Cancer Biol Med, 2016 May 05; 13(1). PMID: 27144065    Free PMC article.
Second-line panitumumab as a triweekly dose for patients with wild-type KRAS exon 2 metastatic colorectal cancer: a single-institution experience.
Mohamed A Daoud, Engy M Aboelnaga, Wael M Mohamed.
Cancer Biol Med, 2016 May 05; 13(1). PMID: 27144068    Free PMC article.
PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2.
Nan Li, Lin Feng, +6 authors, Junjie Chen.
Cell Rep, 2016 May 07; 15(4). PMID: 27149849    Free PMC article.
Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.
Adam D Pfefferle, Yash N Agrawal, +5 authors, Charles M Perou.
Dis Model Mech, 2016 May 07; 9(7). PMID: 27149990    Free PMC article.
Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance.
Yuetong Wang, Hsin-Yi Huang, +2 authors, Hongbin Ji.
Sci Rep, 2016 May 07; 6. PMID: 27151505    Free PMC article.
Epidermal Growth Factor Receptor in Prostate Cancer Derived Exosomes.
Geetanjali Kharmate, Elham Hosseini-Beheshti, +2 authors, Emma S Tomlinson Guns.
PLoS One, 2016 May 07; 11(5). PMID: 27152724    Free PMC article.
Immunotoxin Therapies for the Treatment of Epidermal Growth Factor Receptor-Dependent Cancers.
Nathan Simon, David FitzGerald.
Toxins (Basel), 2016 May 07; 8(5). PMID: 27153091    Free PMC article.
MiR-374a suppresses lung adenocarcinoma cell proliferation and invasion by targeting TGFA gene expression.
Haijian Wu, Yan Liu, Xiao Ou Shu, Qiuyin Cai.
Carcinogenesis, 2016 May 22; 37(6). PMID: 27207663    Free PMC article.
A Novel EGFR Extracellular Domain Mutant, EGFRΔ768, Possesses Distinct Biological and Biochemical Properties in Neuroblastoma.
James Keller, Anjaruwee S Nimnual, +3 authors, Edward L Chan.
Mol Cancer Res, 2016 May 25; 14(8). PMID: 27216155    Free PMC article.
Effects of epidermal growth factor receptor kinase inhibition on radiation response in canine osteosarcoma cells.
Fernanda B Mantovani, Jodi A Morrison, Anthony J Mutsaers.
BMC Vet Res, 2016 Jun 02; 12. PMID: 27245053    Free PMC article.
PA-MSHA in combination with EGFR tyrosine kinase inhibitor: A new strategy to overcome the drug resistance of non-small cell lung cancer cells.
Xin-Min Zhao, Shi-Yun Pan, +8 authors, Xiao-Long Fu.
Oncotarget, 2016 Jun 11; 7(31). PMID: 27283902    Free PMC article.
Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D.
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang.
Oncotarget, 2016 Jun 11; 7(27). PMID: 27286447    Free PMC article.
Influence maximization in time bounded network identifies transcription factors regulating perturbed pathways.
Kyuri Jo, Inuk Jung, Ji Hwan Moon, Sun Kim.
Bioinformatics, 2016 Jun 17; 32(12). PMID: 27307609    Free PMC article.
Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far.
Yijun Xu, Vivianne W Ding, +3 authors, Biao He.
Ther Clin Risk Manag, 2016 Jun 17; 12. PMID: 27307741    Free PMC article.
Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting.
Hui Li, Kaiming Zhang, +5 authors, Peixuan Guo.
Adv Mater, 2016 Jun 21; 28(34). PMID: 27322097    Free PMC article.
Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: A large-scale multicenter study in China.
Guo-Shuang Shen, Jiu-Da Zhao, +8 authors, Bing-He Xu.
World J Gastroenterol, 2016 Jun 25; 22(23). PMID: 27340357    Free PMC article.
Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients.
Chen Jing, Yang Han Jin, +2 authors, Zhou Jun.
Oncotarget, 2016 Jun 28; 7(34). PMID: 27344184    Free PMC article.
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2.
H Dong, L Ma, +11 authors, H Zhang.
Oncogene, 2016 Jun 28; 36(3). PMID: 27345410    Free PMC article.
Characterization of a P-Rex1 gene signature in breast cancer cells.
Laura Barrio-Real, Eva Wertheimer, +2 authors, Marcelo G Kazanietz.
Oncotarget, 2016 Jun 29; 7(32). PMID: 27351228    Free PMC article.
HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models.
Dongsheng Wang, Guoqing Qian, +12 authors, Zhuo G Chen.
Clin Cancer Res, 2016 Jul 01; 23(3). PMID: 27358485    Free PMC article.
Discovery of a Potential HER2 Inhibitor from Natural Products for the Treatment of HER2-Positive Breast Cancer.
Jianzong Li, Haiyang Wang, +2 authors, Chuanfang Wu.
Int J Mol Sci, 2016 Jul 05; 17(7). PMID: 27376283    Free PMC article.
Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations.
Jun Wang, Baocheng Wang, Huili Chu, Yunfeng Yao.
Onco Targets Ther, 2016 Jul 07; 9. PMID: 27382309    Free PMC article.
Detection of HER2 polymorphism and expression using circulating DNA and RNA as a tool in lung adenocarcinoma patients: a case control study.
Masroor Mirza, Jamsheed Javid, +3 authors, Alpana Saxena.
Ann Transl Med, 2016 Jul 08; 4(11). PMID: 27386483    Free PMC article.
Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis.
Sihua Wang, Yuan Zhang, +5 authors, Jiahong Xia.
J Biol Chem, 2016 Jul 20; 291(40). PMID: 27432879    Free PMC article.
A Phase I Trial to Evaluate Antibody-Dependent Cellular Cytotoxicity of Cetuximab and Lenalidomide in Advanced Colorectal and Head and Neck Cancer.
Erin M Bertino, Elizabeth L McMichael, +6 authors, Gregory A Otterson.
Mol Cancer Ther, 2016 Jul 28; 15(9). PMID: 27458141    Free PMC article.
Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations.
Mickaël Lelimousin, Vittorio Limongelli, Mark S P Sansom.
J Am Chem Soc, 2016 Jul 28; 138(33). PMID: 27459426    Free PMC article.
Blood-based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance).
Ace J Hatch, Alexander B Sibley, +12 authors, Alliance for Clinical Trials in Oncology.
Cancer Med, 2016 Jul 29; 5(9). PMID: 27465221    Free PMC article.
Total and mutated EGFR quantification in cell-free DNA from non-small cell lung cancer patients detects tumor heterogeneity and presents prognostic value.
E Alegre, J P Fusco, +12 authors, A Gonzalez.
Tumour Biol, 2016 Jul 31; 37(10). PMID: 27473086
Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation.
Xiumei Sheng, Zhengxin Wang.
BMC Cancer, 2016 Aug 03; 16. PMID: 27480244    Free PMC article.
Current targeted therapies in the treatment of advanced colorectal cancer: a review.
Andrew Moriarity, Jacintha O'Sullivan, +2 authors, Paul McCormick.
Ther Adv Med Oncol, 2016 Aug 03; 8(4). PMID: 27482287    Free PMC article.
uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R.
Michaela C Huber, Rebecca Mall, +8 authors, Michaela Aubele.
BMC Cancer, 2016 Aug 10; 16. PMID: 27502396    Free PMC article.
Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas.
Francesca Mascia, Derek T Schloemann, +4 authors, Stuart H Yuspa.
Int J Cancer, 2016 Aug 11; 139(11). PMID: 27509256    Free PMC article.
Trastuzumab improves locoregional control in HER2-positive breast cancer patients following adjuvant radiotherapy.
Lu Cao, Gang Cai, +7 authors, Jia-Yi Chen.
Medicine (Baltimore), 2016 Aug 12; 95(32). PMID: 27512838    Free PMC article.
Integrative regression network for genomic association study.
Reddy Rani Vangimalla, Hyun-Hwan Jeong, Kyung-Ah Sohn.
BMC Med Genomics, 2016 Aug 19; 9 Suppl 1. PMID: 27535739    Free PMC article.
HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis.
Guo-Dong Cao, Ke Chen, Mao-Ming Xiong, Bo Chen.
PLoS One, 2016 Aug 19; 11(8). PMID: 27536774    Free PMC article.
Systematic Review.
Exploring Missense Mutations in Tyrosine Kinases Implicated with Neurodegeneration.
Neha Sami, Vijay Kumar, +3 authors, Imtaiyaz Hassan.
Mol Neurobiol, 2016 Aug 22; 54(7). PMID: 27544236
Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis.
Hope M Amm, Mary MacDougall.
Curr Oral Health Rep, 2016 Aug 23; 3(2). PMID: 27547697    Free PMC article.
A chemoproteomic method for identifying cellular targets of covalent kinase inhibitors.
Ying-Chu Chen, Chao Zhang.
Genes Cancer, 2016 Aug 24; 7(5-6). PMID: 27551330    Free PMC article.
Role of EGF/ERBB1 in the transcriptional regulation of the prolactin receptor independent of estrogen and prolactin in breast cancer cells.
Raghuveer Kavarthapu, Maria L Dufau.
Oncotarget, 2016 Aug 27; 7(40). PMID: 27564112    Free PMC article.
Molecular mechanisms of peritoneal dissemination in gastric cancer.
Mitsuro Kanda, Yasuhiro Kodera.
World J Gastroenterol, 2016 Aug 30; 22(30). PMID: 27570420    Free PMC article.
Optimal Objective-Based Experimental Design for Uncertain Dynamical Gene Networks with Experimental Error.
Daniel N Mohsenizadeh, Roozbeh Dehghannasiri, Edward R Dougherty.
IEEE/ACM Trans Comput Biol Bioinform, 2016 Sep 01; 15(1). PMID: 27576263    Free PMC article.
Antiangiogenic antibody improves melanoma detection by fluorescently labeled therapeutic antibodies.
Larissa Sweeny, Andrew Prince, +4 authors, Jason M Warram.
Laryngoscope, 2016 Sep 01; 126(12). PMID: 27576611    Free PMC article.
TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations.
Raffaella Castoldi, Jürgen Schanzer, +9 authors, Claudio Sustmann.
Protein Eng Des Sel, 2016 Sep 01; 29(10). PMID: 27578890    Free PMC article.
TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation.
J Kang, W Kim, +7 authors, B Youn.
Oncogene, 2016 Sep 07; 36(11). PMID: 27593936
Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer.
Vincenzo Sforza, Erika Martinelli, +10 authors, Teresa Troiani.
World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605871    Free PMC article.
13-Methyl-palmatrubine induces apoptosis and cell cycle arrest in A549 cells in vitro and in vivo.
Jingxian Chen, Xingang Lu, +6 authors, Wangchun Du.
Oncol Rep, 2016 Oct 26; 36(5). PMID: 27633656    Free PMC article.
Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.
Chen Zhang, Bingfei Xu, Pian Liu.
Tumour Biol, 2016 Sep 19; 37(11). PMID: 27639383
Treatment strategies of epidermal growth factor receptor inhibitor-induced skin toxicities: pre-emptive or reactive?
Yung-Tsu Cho, Kai-Lung Chen, Chia-Yu Chu.
Ann Transl Med, 2016 Sep 27; 4(16). PMID: 27668238    Free PMC article.
Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review.
Takahiro Eitsuka, Naoto Tatewaki, +2 authors, Teruo Miyazawa.
Int J Mol Sci, 2016 Sep 27; 17(10). PMID: 27669218    Free PMC article.
Role of targeted therapy in metastatic colorectal cancer.
Yoshihito Ohhara, Naoki Fukuda, +4 authors, Hirotoshi Dosaka-Akita.
World J Gastrointest Oncol, 2016 Sep 28; 8(9). PMID: 27672422    Free PMC article.
Comparative effectiveness of combined therapy inhibiting EGFR and VEGF pathways in patients with advanced non-small-cell lung cancer: a meta-analysis of 16 phase II/III randomized trials.
Yongzhao Zhao, Huixian Wang, +9 authors, Wang Ma.
Oncotarget, 2016 Oct 01; 8(4). PMID: 27690345    Free PMC article.
Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells.
Wei-Chien Huang, Chao-Ming Hung, +5 authors, Yun-Ju Chen.
Oncotarget, 2016 Oct 04; 7(38). PMID: 27694691    Free PMC article.
Cyclin D1, cancer progression, and opportunities in cancer treatment.
Shuo Qie, J Alan Diehl.
J Mol Med (Berl), 2016 Oct 04; 94(12). PMID: 27695879    Free PMC article.
Highly Cited. Review.
Targeted-TERS detection of integrin receptors on human cancer cells.
Lifu Xiao, Zachary D Schultz.
Cancer Cell Microenviron, 2016 Oct 11; 3(4). PMID: 27722181    Free PMC article.
Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.
Anna E Kersh, Maiko Sasaki, +2 authors, Brian P Pollack.
Front Pharmacol, 2016 Oct 13; 7. PMID: 27729860    Free PMC article.
Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells.
Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hisataka Sabe.
Small GTPases, 2016 Oct 19; 9(5). PMID: 27754741    Free PMC article.
Design of a doxorubicin-peptidomimetic conjugate that targets HER2-positive cancer cells.
Sandeep Pallerla, Ted Gauthier, Rushikesh Sable, Seetharama D Jois.
Eur J Med Chem, 2016 Oct 22; 125. PMID: 27769032    Free PMC article.
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Sarah R Needham, Selene K Roberts, +18 authors, Marisa L Martin-Fernandez.
Nat Commun, 2016 Nov 01; 7. PMID: 27796308    Free PMC article.
Highly Cited.
Noscapine targets EGFRp-Tyr1068 to suppress the proliferation and invasion of MG63 cells.
Ming He, Linlin Jiang, +2 authors, Jiashi Wang.
Sci Rep, 2016 Nov 11; 6. PMID: 27830833    Free PMC article.
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
Jung-Chien Cheng, Hsun-Ming Chang, +2 authors, Peter C K Leung.
Oncotarget, 2016 Nov 12; 7(49). PMID: 27835572    Free PMC article.
Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells.
Ting Li, Xin Chen, +3 authors, Jin Jian Lu.
Sci Rep, 2016 Nov 30; 6. PMID: 27897231    Free PMC article.
Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma.
Xinfang Mao, Zhenghu Chen, +10 authors, Jianhua Yang.
Oncotarget, 2016 Dec 03; 8(1). PMID: 27902463    Free PMC article.
Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer.
Peter B Alexander, Rui Chen, +9 authors, Xiao-Fan Wang.
J Biol Chem, 2016 Dec 03; 292(2). PMID: 27903634    Free PMC article.
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
Xiao Wang, Zhen Liang, +10 authors, Liping Xie.
Cell Death Dis, 2016 Dec 03; 7(12). PMID: 27906180    Free PMC article.
Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma.
Sarangarajan Ranganathan, Mylarappa Ningappa, +7 authors, Rakesh Sindhi.
Sci Rep, 2016 Dec 03; 6. PMID: 27910913    Free PMC article.
PHLPPing through history: a decade in the life of PHLPP phosphatases.
Agnieszka T Grzechnik, Alexandra C Newton.
Biochem Soc Trans, 2016 Dec 04; 44(6). PMID: 27913677    Free PMC article.
Epidermal Growth Factor Receptor Status in Circulating Tumor Cells as a Predictive Biomarker of Sensitivity in Castration-Resistant Prostate Cancer Patients Treated with Docetaxel Chemotherapy.
Takatsugu Okegawa, Naoshi Itaya, +2 authors, Kikuo Nutahara.
Int J Mol Sci, 2016 Dec 06; 17(12). PMID: 27916908    Free PMC article.
Toward the use of precision medicine for the treatment of head and neck squamous cell carcinoma.
Wang Gong, Yandi Xiao, +7 authors, Qianming Chen.
Oncotarget, 2016 Dec 08; 8(2). PMID: 27924064    Free PMC article.
A New Method to Study Heterodimerization of Membrane Proteins and Its Application to Fibroblast Growth Factor Receptors.
Nuala Del Piccolo, Sarvenaz Sarabipour, Kalina Hristova.
J Biol Chem, 2016 Dec 09; 292(4). PMID: 27927983    Free PMC article.
HER2/HER3 pathway in biliary tract malignancies; systematic review and meta-analysis: a potential therapeutic target?
Salvatore Galdy, Angela Lamarca, +4 authors, Juan W Valle.
Cancer Metastasis Rev, 2016 Dec 17; 36(1). PMID: 27981460    Free PMC article.
Systematic Review.
Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells.
Qiaoling Song, Xiaoxiao Sun, Hui Guo, Qiang Yu.
Oncotarget, 2016 Dec 22; 8(3). PMID: 28002807    Free PMC article.
Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer.
Xi Zhang, Nadia Harbeck, Udo Jeschke, Sophie Doisneau-Sixou.
J Cancer Res Clin Oncol, 2016 Dec 28; 143(7). PMID: 28025696
Next-Generation Assessment of Human Epidermal Growth Factor Receptor 2 (ERBB2) Amplification Status: Clinical Validation in the Context of a Hybrid Capture-Based, Comprehensive Solid Tumor Genomic Profiling Assay.
Dara S Ross, Ahmet Zehir, +11 authors, Maria E Arcila.
J Mol Diagn, 2016 Dec 29; 19(2). PMID: 28027945    Free PMC article.
Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells.
Albert Bosch-Vilaró, Bart Jacobs, +11 authors, Sabine Tejpar.
Oncotarget, 2016 Dec 30; 8(3). PMID: 28032592    Free PMC article.
Genomic sequencing and precision medicine in head and neck cancers.
R C Hoesli, M L Ludwig, +4 authors, A C Birkeland.
Eur J Surg Oncol, 2016 Dec 31; 43(5). PMID: 28034498    Free PMC article.
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer.
Nina Kozlova, Marieke Wottawa, +2 authors, Thomas Kietzmann.
Oncotarget, 2016 Dec 31; 8(6). PMID: 28038470    Free PMC article.
Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice.
Zhikun Ma, Amanda B Parris, +4 authors, Xiaohe Yang.
J Exp Clin Cancer Res, 2017 Jan 08; 36(1). PMID: 28061785    Free PMC article.
Septins: Regulators of Protein Stability.
Olga Vagin, David O Beenhouwer.
Front Cell Dev Biol, 2017 Jan 10; 4. PMID: 28066764    Free PMC article.
EGFR family and cMet expression profiles and prognostic significance in esophagogastric adenocarcinoma.
Ellie Chan, Ahmad Alkhasawneh, +6 authors, Thomas J George.
J Gastrointest Oncol, 2017 Jan 13; 7(6). PMID: 28078108    Free PMC article.
Antitumor Efficacy of SLPI Promoter-Controlled Expression of Artificial microRNA Targeting EGFR in a Squamous Cell Carcinoma Cell Line.
Jia Chen, Shoude Zhang, +2 authors, Jiang Cao.
Pathol Oncol Res, 2017 Jan 20; 23(4). PMID: 28101799
WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer.
Vassiliki Saloura, Theodore Vougiouklakis, +9 authors, Yusuke Nakamura.
Sci Rep, 2017 Jan 20; 7. PMID: 28102297    Free PMC article.
HER2 overexpression reverses the relative resistance of EGFR-mutant H1975 cell line to gefitinib.
Jing Xu, Li Shen, +4 authors, Qi-Chun Wei.
Oncol Lett, 2017 Jan 21; 12(6). PMID: 28105244    Free PMC article.
Costs of adverse events associated with erlotinib or afatinib in first-line treatment of advanced EGFR-positive non-small cell lung cancer.
Dolores Isla, Javier De Castro, +5 authors, Darío Rubio-Rodríguez.
Clinicoecon Outcomes Res, 2017 Jan 25; 9. PMID: 28115857    Free PMC article.
Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.
Viktoras Frismantas, Maria Pamela Dobay, +34 authors, Jean-Pierre Bourquin.
Blood, 2017 Jan 27; 129(11). PMID: 28122742    Free PMC article.
Highly Cited.
Long-term treatment with EGFR inhibitor erlotinib attenuates renal inflammatory cytokines but not nephropathy in Alport syndrome mouse model.
Kohei Omachi, Rui Miyakita, +6 authors, Hirofumi Kai.
Clin Exp Nephrol, 2017 Feb 09; 21(6). PMID: 28176019
Determining EGFR-TKI sensitivity of G719X and other uncommon EGFR mutations in non-small cell lung cancer: Perplexity and solution (Review).
Kaidi Li, Maojun Yang, Naixin Liang, Shanqing Li.
Oncol Rep, 2017 Feb 12; 37(3). PMID: 28184913    Free PMC article.
Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer.
Saswati Banerjee, Santosh K Singh, +2 authors, Rajesh Singh.
Front Biosci (Elite Ed), 2017 Feb 16; 9. PMID: 28199187    Free PMC article.
Development of personalized treatments in lung cancer: focusing on the EGFR mutations and beyond.
Kenichi Suda, Tetsuya Mitsudomi.
Lung Cancer (Auckl), 2013 Aug 14; 4. PMID: 28210134    Free PMC article.
Epiregulin as a therapeutic target in non-small-cell lung cancer.
Noriaki Sunaga, Kyoichi Kaira.
Lung Cancer (Auckl), 2015 Oct 12; 6. PMID: 28210154    Free PMC article.
A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells.
Anna M Serwotka-Suszczak, Alicja M Sochaj-Gregorczyk, +3 authors, Jacek Otlewski.
Int J Mol Sci, 2017 Feb 22; 18(2). PMID: 28216573    Free PMC article.
ERBB signaling attenuates proinflammatory activation of nonclassical monocytes.
Sergey Ryzhov, Anton Matafonov, +6 authors, Douglas B Sawyer.
Am J Physiol Heart Circ Physiol, 2017 Feb 27; 312(5). PMID: 28235789    Free PMC article.
Aberrant Signaling through the HER2-ERK1/2 Pathway is Predictive of Reduced Disease-Free and Overall Survival in Early Stage Non-Small Cell Lung Cancer (NSCLC) Patients.
Marianna Scrima, Federica Zito Marino, +11 authors, Giuseppe Viglietto.
J Cancer, 2017 Mar 01; 8(2). PMID: 28243327    Free PMC article.
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells.
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma.
Ann Transl Med, 2017 Mar 03; 5(3). PMID: 28251140    Free PMC article.
ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases.
Alexandru Filippi, Oana-Alina Ciolac, Constanța Ganea, Maria-Magdalena Mocanu.
J Oncol, 2017 Mar 14; 2017. PMID: 28286519    Free PMC article.
Distinct ErbB2 receptor populations differentially interact with beta1 integrin in breast cancer cell models.
Andrés Martín Toscani, Rocío G Sampayo, +3 authors, Federico Coluccio Leskow.
PLoS One, 2017 Mar 18; 12(3). PMID: 28306722    Free PMC article.
Combinational therapy of crizotinib and afatinib for malignant pleural mesothelioma.
Liyan Huang, Muyan Cai, +7 authors, Liwu Fu.
Am J Cancer Res, 2017 Mar 25; 7(2). PMID: 28337371    Free PMC article.
EGFR Family Members' Regulation of Autophagy Is at a Crossroads of Cell Survival and Death in Cancer.
Elizabeth Henson, Yongqiang Chen, Spencer Gibson.
Cancers (Basel), 2017 Mar 25; 9(4). PMID: 28338617    Free PMC article.
Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer.
Hai Hu, Ting Han, +6 authors, Li-Wei Wang.
Sci Rep, 2017 Mar 30; 7(1). PMID: 28352075    Free PMC article.
Chimeric antigen receptor T cells: a novel therapy for solid tumors.
Shengnan Yu, Anping Li, +4 authors, Kongming Wu.
J Hematol Oncol, 2017 Mar 31; 10(1). PMID: 28356156    Free PMC article.
Highly Cited. Review.
Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response.
Sandra Jernström, Vesa Hongisto, +7 authors, Kristine Kleivi Sahlberg.
Breast Cancer (Dove Med Press), 2017 Mar 31; 9. PMID: 28356768    Free PMC article.
Targeted Therapy in Head and Neck Cancer: An Update on Current Clinical Developments in Epidermal Growth Factor Receptor-Targeted Therapy and Immunotherapies.
Jonathan Moreira, Alexander Tobias, Michael P O'Brien, Mark Agulnik.
Drugs, 2017 Apr 07; 77(8). PMID: 28382569
Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesis.
Navin Viswakarma, Rakesh Sathish Nair, +6 authors, Ajay Rana.
Oncotarget, 2017 Apr 08; 8(20). PMID: 28388540    Free PMC article.
Synthesis of BODIPY-Peptide Conjugates for Fluorescence Labeling of EGFR Overexpressing Cells.
Ning Zhao, Tyrslai M Williams, +4 authors, M Graça H Vicente.
Bioconjug Chem, 2017 Apr 18; 28(5). PMID: 28414435    Free PMC article.
Tyrosine kinase inhibitor induced growth factor receptor upregulation enhances the efficacy of near-infrared targeted photodynamic therapy in esophageal adenocarcinoma cell lines.
Elmire Hartmans, Matthijs D Linssen, +4 authors, Wouter B Nagengast.
Oncotarget, 2017 Apr 19; 8(18). PMID: 28415738    Free PMC article.
RHBDD1 upregulates EGFR via the AP-1 pathway in colorectal cancer.
Fei Miao, Mengmeng Zhang, +10 authors, Linfang Wang.
Oncotarget, 2017 Apr 28; 8(15). PMID: 28445956    Free PMC article.
A bispecific enediyne-energized fusion protein targeting both epidermal growth factor receptor and insulin-like growth factor 1 receptor showing enhanced antitumor efficacy against non-small cell lung cancer.
Xiao-Fang Guo, Xiao-Fei Zhu, +7 authors, Yong-Su Zhen.
Oncotarget, 2017 May 04; 8(16). PMID: 28460483    Free PMC article.
Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment.
Zhenguang Wang, Yelei Guo, Weidong Han.
Protein Cell, 2017 May 04; 8(12). PMID: 28466386    Free PMC article.
Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine.
Yuji Baba, Toshiya Tamura, +6 authors, Kazuhide Nakamura.
Mol Oncol, 2017 May 10; 11(8). PMID: 28486761    Free PMC article.
Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters.
Pedro Caetano-Pinto, Amer Jamalpoor, +11 authors, Rosalinde Masereeuw.
Mol Pharm, 2017 May 12; 14(6). PMID: 28493713    Free PMC article.
Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades.
Hanwool Lee, Seung Ho Baek, +9 authors, Kwang Seok Ahn.
Int J Mol Sci, 2017 May 24; 18(5). PMID: 28534824    Free PMC article.
Purpuric Drug Eruptions Caused by Epidermal Growth Factor Receptor Inhibitors for Non-Small Cell Lung Cancer: A Clinicopathologic Study of 32 Cases.
Yung-Tsu Cho, Kai-Lung Chen, +4 authors, Chia-Yu Chu.
JAMA Dermatol, 2017 May 26; 153(9). PMID: 28538945    Free PMC article.
Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The "Rotation Model".
Endang R Purba, Ei-Ichiro Saita, Ichiro N Maruyama.
Cells, 2017 Jun 03; 6(2). PMID: 28574446    Free PMC article.
Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression.
Taeyoung Koo, A-Rum Yoon, +3 authors, Jin-Soo Kim.
Nucleic Acids Res, 2017 Jun 03; 45(13). PMID: 28575452    Free PMC article.
Golgi phosphoprotein 3 promotes glioma progression via inhibiting Rab5-mediated endocytosis and degradation of epidermal growth factor receptor.
Xiuping Zhou, Shao Xie, +11 authors, Rutong Yu.
Neuro Oncol, 2017 Jun 03; 19(12). PMID: 28575494    Free PMC article.
Bioinformatics analysis of transcription profiling of solid pseudopapillary neoplasm of the pancreas.
Yongping Zhang, Xu Han, Hao Wu, Yifeng Zhou.
Mol Med Rep, 2017 Jun 20; 16(2). PMID: 28627654    Free PMC article.
Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
Yuichiro Yoshioka, Takehiro Suzuki, +5 authors, Ryuji Hamamoto.
Cancer Med, 2017 Jun 24; 6(7). PMID: 28639750    Free PMC article.
Cardio-Oncology: Cancer Therapy-related Cardiovascular Complications in a Molecular Targeted Era: New Concepts and Perspectives.
David Hurtado-de-Mendoza, Arturo Loaiza-Bonilla, +2 authors, Rodrigo Alcorta.
Cureus, 2017 Jun 27; 9(5). PMID: 28649481    Free PMC article.
Chromosome 7 Multiplication in EGFR-positive Lung Carcinomas Based on Tissue Microarray Analysis.
Evangelos Tsiambas, Nicholas S Mastronikolis, +9 authors, Konstantinos Syrigos.
In Vivo, 2017 Jun 28; 31(4). PMID: 28652432    Free PMC article.
Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment.
Alessia Bignucolo, Elena De Mattia, +2 authors, Giuseppe Toffoli.
Int J Mol Sci, 2017 Jul 15; 18(7). PMID: 28708103    Free PMC article.
Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers.
Kaichao Feng, Yang Liu, +6 authors, Weidong Han.
Protein Cell, 2017 Jul 16; 9(10). PMID: 28710747    Free PMC article.
CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.
Stephen Bridgett, James Campbell, Christopher J Lord, Colm J Ryan.
Cell Syst, 2017 Jul 18; 5(1). PMID: 28711281    Free PMC article.
Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A.
Wei Wang, Honghong Zhang, +9 authors, Chonghui Cheng.
Proc Natl Acad Sci U S A, 2017 Jul 19; 114(31). PMID: 28716909    Free PMC article.
Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.
Tushar Piyush, Anisha R Chacko, +3 authors, Lu-Gang Yu.
Cell Death Differ, 2017 Jul 22; 24(11). PMID: 28731466    Free PMC article.
Quantifying the Interaction between EGFR Dimers and Grb2 in Live Cells.
Nuala Del Piccolo, Kalina Hristova.
Biophys J, 2017 Jul 25; 113(6). PMID: 28734476    Free PMC article.
Predictive and prognostic biomarkers in personalized gastrointestinal cancer treatment.
Helena Verdaguer, Tamara Saurí, Teresa Macarulla.
J Gastrointest Oncol, 2017 Jul 25; 8(3). PMID: 28736628    Free PMC article.
EGFR as a prognostic biomarker and therapeutic target in ovarian cancer: evaluation of patient cohort and literature review.
Christine Mehner, Ann L Oberg, +8 authors, Evette S Radisky.
Genes Cancer, 2017 Jul 26; 8(5-6). PMID: 28740577    Free PMC article.
The addition of calcitriol or its synthetic analog EB1089 to lapatinib and neratinib treatment inhibits cell growth and promotes apoptosis in breast cancer cells.
Mariana Segovia-Mendoza, Lorenza Díaz, +3 authors, Rocío García-Becerra.
Am J Cancer Res, 2017 Jul 27; 7(7). PMID: 28744399    Free PMC article.
Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway.
D Ding, H Huang, +8 authors, L Yu.
Oncogene, 2017 Jul 27; 36(48). PMID: 28745317
Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo.
Weiwei Yu, Weiqiang Lu, +5 authors, Xiufeng Pang.
Br J Pharmacol, 2017 Jul 28; 174(20). PMID: 28749535    Free PMC article.
Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1.
H-B Qiu, W Zhuang, +9 authors, X-D Wang.
Pharmacogenomics J, 2017 Aug 02; 18(3). PMID: 28762371
Present and future of metastatic colorectal cancer treatment: A review of new candidate targets.
Giulia Martini, Teresa Troiani, +11 authors, Erika Martinelli.
World J Gastroenterol, 2017 Aug 03; 23(26). PMID: 28765689    Free PMC article.
Altered expression of cellular proliferation, apoptosis and the cell cycle-related genes in lung cancer cells with acquired resistance to EGFR tyrosine kinase inhibitors.
Tae-Gul Lee, Eun-Hui Jeong, +3 authors, Cheol Hyeon Kim.
Oncol Lett, 2017 Aug 07; 14(2). PMID: 28781659    Free PMC article.
In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer.
Michiko Kodama, Takahiro Kodama, +13 authors, Nancy A Jenkins.
Proc Natl Acad Sci U S A, 2017 Aug 16; 114(35). PMID: 28811376    Free PMC article.
The efficacy and toxicity of afatinib in advanced EGFR-positive non-small-cell lung cancer patients after failure of first-generation tyrosine kinase inhibitors: a systematic review and meta-analysis.
Yaxiong Zhang, Siyu Miao, +8 authors, Li Zhang.
J Thorac Dis, 2017 Aug 26; 9(7). PMID: 28839997    Free PMC article.
Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome.
Jae-Young Kim, Joo-Yong Lee.
Int J Mol Sci, 2017 Aug 26; 18(9). PMID: 28841148    Free PMC article.
Phase 1 Studies of Poziotinib, an Irreversible Pan-HER Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors.
Tae Min Kim, Keun-Wook Lee, +10 authors, Yung-Jue Bang.
Cancer Res Treat, 2017 Sep 02; 50(3). PMID: 28859471    Free PMC article.
Osimertinib in the treatment of non-small-cell lung cancer: design, development and place in therapy.
Mariacarmela Santarpia, Alessia Liguori, +6 authors, Rafael Rosell.
Lung Cancer (Auckl), 2017 Sep 02; 8. PMID: 28860885    Free PMC article.
Structural basis of a novel heterodimeric Fc for bispecific antibody production.
Hudie Wei, Haiyan Cai, +8 authors, Aiwu Zhou.
Oncotarget, 2017 Sep 09; 8(31). PMID: 28881627    Free PMC article.
siRNA-mediated inactivation of HER3 improves the antitumour activity and sensitivity of gefitinib in gastric cancer cells.
Heng-Heng Yuan, Ying-Nan Yang, +13 authors, Yu Han.
Oncotarget, 2017 Sep 09; 8(32). PMID: 28881753    Free PMC article.
FGFR inhibitor, AZD4547, impedes the stemness of mammary epithelial cells in the premalignant tissues of MMTV-ErbB2 transgenic mice.
Qingxia Zhao, Amanda B Parris, +5 authors, Xiaohe Yang.
Sci Rep, 2017 Sep 14; 7(1). PMID: 28900173    Free PMC article.
FEN1 knockdown improves trastuzumab sensitivity in human epidermal growth factor 2-positive breast cancer cells.
Xue Zeng, Xiaofang Che, +6 authors, Yuee Teng.
Exp Ther Med, 2017 Sep 16; 14(4). PMID: 28912877    Free PMC article.
Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires.
Genevieve Conant, Samad Ahadian, Yimu Zhao, Milica Radisic.
Sci Rep, 2017 Sep 20; 7(1). PMID: 28924210    Free PMC article.
Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells.
Ming Zhao, Erin W Howard, +8 authors, Xiaohe Yang.
Oncotarget, 2017 Sep 25; 8(35). PMID: 28938602    Free PMC article.
Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.
Takafumi Nakagaki, Miyuki Tamura, +8 authors, Yasushi Sasaki.
Oncotarget, 2017 Sep 25; 8(35). PMID: 28938622    Free PMC article.
Cooperative but distinct early co-signaling events originate from ERBB2 and ERBB1 receptors upon trastuzumab treatment in breast cancer cells.
Paola Bagnato, Alessia Castagnino, +8 authors, Carlo Tacchetti.
Oncotarget, 2017 Sep 28; 8(36). PMID: 28947957    Free PMC article.
Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives.
Liuchang Wang, Pengna Li, +3 authors, Limei Song.
Molecules, 2017 Sep 29; 22(10). PMID: 28956845    Free PMC article.
Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer.
Kunlin Xie, Yuanqing Ye, +3 authors, Xifeng Wu.
Carcinogenesis, 2017 Oct 03; 38(10). PMID: 28968839    Free PMC article.
Therapeutic efficacy of SYM004, a mixture of two anti-EGFR antibodies in human colorectal cancer with acquired resistance to cetuximab and MET activation.
Stefania Napolitano, Giulia Martini, +8 authors, Teresa Troiani.
Oncotarget, 2017 Oct 06; 8(40). PMID: 28978055    Free PMC article.
Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers.
Samantha S Dykes, Joshua J Steffan, James A Cardelli.
BMC Cancer, 2017 Oct 06; 17(1). PMID: 28978320    Free PMC article.
[Nuclear Her2 expression in hepatocytes in liver disease].
P Döring, G M Pilo, D F Calvisi, F Dombrowski.
Pathologe, 2017 Oct 12; 38(Suppl 2). PMID: 29018945
Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.
Ana Orive-Ramos, Samuel Seoane, +2 authors, Juan Carlos Montero.
Mol Oncol, 2017 Oct 17; 11(12). PMID: 29032615    Free PMC article.
HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma.
Hiroyuki Matsuda, Carole G Campion, +13 authors, Johanne Tremblay.
Oncotarget, 2017 Oct 21; 8(41). PMID: 29050225    Free PMC article.
Prognostic and predictive value of serum carcinoembryonic antigen levels in advanced non-small cell lung cancer patients with epidermal growth factor receptor sensitive mutations and receiving tyrosine kinase inhibitors.
Xin Min Zhao, Jing Zhao, +6 authors, Xiang Hua Wu.
Oncotarget, 2017 Oct 21; 8(41). PMID: 29050327    Free PMC article.
Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk.
Elizabeth S Mo, Qianni Cheng, +2 authors, Stefania Nicoli.
Proc Natl Acad Sci U S A, 2017 Oct 29; 114(45). PMID: 29078341    Free PMC article.
Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors.
Mostafa M Ghorab, Mansour S Alsaid, Aiten M Soliman, Abdullah A Al-Mishari.
J Enzyme Inhib Med Chem, 2017 Nov 04; 33(1). PMID: 29098904    Free PMC article.
Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor.
Henrique O Duarte, Meritxell Balmaña, +3 authors, Celso A Reis.
Int J Mol Sci, 2017 Nov 17; 18(11). PMID: 29143776    Free PMC article.
Synthesis and anticancer activity of new quinazoline derivatives.
Hatem A Abuelizz, Mohamed Marzouk, Hazem Ghabbour, Rashad Al-Salahi.
Saudi Pharm J, 2017 Nov 22; 25(7). PMID: 29158714    Free PMC article.
Long non-coding RNAs in Colorectal Cancer: Progression and Future Directions.
Yongzhi Yang, Peng Junjie, Cai Sanjun, Yanlei Ma.
J Cancer, 2017 Nov 22; 8(16). PMID: 29158793    Free PMC article.
Identification of epidermal growth factor receptor-positive glioblastoma using lipid-encapsulated targeted superparamagnetic iron oxide nanoparticles in vitro.
Huai-Lu Chen, Fei-Ting Hsu, +8 authors, Cheng-Yu Chen.
J Nanobiotechnology, 2017 Nov 24; 15(1). PMID: 29166921    Free PMC article.
Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression.
Fengmei Pi, Daniel W Binzel, +10 authors, Peixuan Guo.
Nat Nanotechnol, 2017 Dec 13; 13(1). PMID: 29230043    Free PMC article.
Highly Cited.
Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients.
Guo-Dong Cao, Ke Chen, Bo Chen, Mao-Ming Xiong.
BMC Cancer, 2017 Dec 14; 17(1). PMID: 29233126    Free PMC article.
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis.
Simone Keller, Julia Kneissl, +6 authors, Birgit Luber.
BMC Cancer, 2017 Dec 15; 17(1). PMID: 29237412    Free PMC article.
Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy?
Young Kwang Chae, Ayush Arya, +9 authors, Francis Giles.
Oncotarget, 2017 Dec 17; 8(59). PMID: 29246028    Free PMC article.
miR-152 is involved in the proliferation and metastasis of ovarian cancer through repression of ERBB3.
Lian-Wei Li, Hong-Qi Xiao, +3 authors, Ge Lou.
Int J Mol Med, 2017 Dec 30; 41(3). PMID: 29286064    Free PMC article.
Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications.
Hamid R Mirzaei, Analiz Rodriguez, +2 authors, Behnam Badie.
Front Immunol, 2018 Jan 10; 8. PMID: 29312333    Free PMC article.
Highly Cited. Review.
Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.
Giulia Bon, Rossella Loria, +11 authors, Rita Falcioni.
Oncotarget, 2016 Aug 19; 8(65). PMID: 29312543    Free PMC article.
Overexpression of SCAMP3 is an indicator of poor prognosis in hepatocellular carcinoma.
Xinyuan Zhang, Jie Sheng, +5 authors, Rongkuan Li.
Oncotarget, 2018 Jan 10; 8(65). PMID: 29312605    Free PMC article.
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
Chao Jing, Xin Qu, +13 authors, Xuan Zhou.
Am J Cancer Res, 2018 Jan 10; 7(12). PMID: 29312802    Free PMC article.
Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis.
Janelle Mapes, Lavanya Anandan, +4 authors, Milan K Bagchi.
J Biol Chem, 2018 Jan 13; 293(8). PMID: 29321207    Free PMC article.
Differential recruitment of CD44 isoforms by ErbB ligands reveals an involvement of CD44 in breast cancer.
Iris Morath, Christian Jung, +4 authors, Véronique Orian-Rousseau.
Oncogene, 2018 Jan 13; 37(11). PMID: 29321661
Phase I open-label study of afatinib plus vinorelbine in patients with solid tumours overexpressing EGFR and/or HER2.
Rastislav Bahleda, Andrea Varga, +5 authors, Jean-Pierre Delord.
Br J Cancer, 2018 Jan 18; 118(3). PMID: 29337963    Free PMC article.
VEGF Signaling in Neurological Disorders.
Joon W Shim, Joseph R Madsen.
Int J Mol Sci, 2018 Jan 18; 19(1). PMID: 29342116    Free PMC article.
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.
Amanda Tomie Ouchida, Yingbo Li, +5 authors, Junying Yuan.
Cell Death Dis, 2018 Jan 28; 9(2). PMID: 29374185    Free PMC article.
Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.
Erika Martinelli, Teresa Troiani, +11 authors, Fortunato Ciardiello.
ESMO Open, 2018 Feb 02; 3(1). PMID: 29387480    Free PMC article.
EGFR expression in circulating tumor cells from high-grade metastatic soft tissue sarcomas.
Alexcia Camila Braun, Celso Abdon Lopes de Mello, +10 authors, Ludmilla Thomé Domingos Chinen.
Cancer Biol Ther, 2018 Feb 03; 19(6). PMID: 29394136    Free PMC article.
A phase I study of afatinib for patients aged 75 or older with advanced non-small cell lung cancer harboring EGFR mutations.
Hisashi Tanaka, Kageaki Taima, +7 authors, Sadatomo Tasaka.
Med Oncol, 2018 Feb 10; 35(3). PMID: 29423683    Free PMC article.
Design of cyclic and d-amino acids containing peptidomimetics for inhibition of protein-protein interactions of HER2-HER3.
Sandeep Pallerla, Himgauri Naik, +3 authors, Seetharama D Jois.
J Pept Sci, 2018 Feb 13; 24(2). PMID: 29436155    Free PMC article.
Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction.
Takayoshi Matsuda, Takuhiro Ito, +7 authors, Mikako Shirouzu.
PLoS One, 2018 Feb 21; 13(2). PMID: 29462206    Free PMC article.
Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration.
Sabrina Maisel, Derrick Broka, Joyce Schroeder.
Oncotarget, 2018 Feb 22; 9(5). PMID: 29464085    Free PMC article.
The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2.
Hamid Maadi, Babak Nami, +2 authors, Zhixiang Wang.
BMC Cancer, 2018 Mar 02; 18(1). PMID: 29490608    Free PMC article.
Role of Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme.
Vishal Jindal.
Mol Neurobiol, 2018 Mar 11; 55(11). PMID: 29524050
Use of the tumor-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to combination therapy with pertuzumab, trastuzumab, and docetaxel for advanced HER2-positive breast cancer.
Koji Takada, Shinichiro Kashiwagi, +7 authors, Masaichi Ohira.
J Transl Med, 2018 Apr 05; 16(1). PMID: 29615076    Free PMC article.
δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer.
Nensi Shrestha, Hridaya Shrestha, +8 authors, Kwonseop Kim.
Mol Cells, 2018 Apr 10; 41(4). PMID: 29629558    Free PMC article.
Molecular spherical nucleic acids.
Hui Li, Bohan Zhang, +9 authors, Chad A Mirkin.
Proc Natl Acad Sci U S A, 2018 Apr 11; 115(17). PMID: 29632214    Free PMC article.
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.
Maximilian R Stammnitz, Tim H H Coorens, +23 authors, Elizabeth P Murchison.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634948    Free PMC article.
Highly Cited.
Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer.
S Siena, A Sartore-Bianchi, +6 authors, L Trusolino.
Ann Oncol, 2018 Apr 17; 29(5). PMID: 29659677    Free PMC article.
Pathways of topological rank analysis (PoTRA): a novel method to detect pathways involved in hepatocellular carcinoma.
Chaoxing Li, Li Liu, Valentin Dinu.
PeerJ, 2018 Apr 19; 6. PMID: 29666752    Free PMC article.
Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells.
Harry Lee, Nipun Saini, +8 authors, Xiaohe Yang.
Sci Rep, 2018 May 03; 8(1). PMID: 29717218    Free PMC article.
Bioactivating Silicon (100) Surfaces with Novel UV Grafting of Cyclopropylamine for Promotion of Cell Adhesion.
Jing Yuan Ching, Chieh-Hua Lee, Yit Lung Khung.
Materials (Basel), 2018 May 05; 11(5). PMID: 29724039    Free PMC article.
Challenges and prospects of chimeric antigen receptor T cell therapy in solid tumors.
Vishal Jindal, Ena Arora, Sorab Gupta.
Med Oncol, 2018 May 08; 35(6). PMID: 29730801
L718Q mutant EGFR escapes covalent inhibition by stabilizing a non-reactive conformation of the lung cancer drug osimertinib.
D Callegari, K E Ranaghan, +5 authors, A Lodola.
Chem Sci, 2018 May 08; 9(10). PMID: 29732058    Free PMC article.
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Robert E Van Sciver, Michael P Lee, +13 authors, Amy H Tang.
Cancers (Basel), 2018 May 15; 10(5). PMID: 29757973    Free PMC article.
Interaction between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer.
Ce Yuan, Michael B Burns, Subbaya Subramanian, Ran Blekhman.
mSystems, 2018 May 26; 3(3). PMID: 29795787    Free PMC article.
Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma.
Chao Ma, Ji-Zhi Zhao, +8 authors, Tao Zhang.
Oncol Lett, 2018 May 29; 15(6). PMID: 29805672    Free PMC article.
Oridonin inhibits aberrant AKT activation in breast cancer.
Bowen Sun, Geng Wang, +14 authors, Qi Wang.
Oncotarget, 2018 May 31; 9(35). PMID: 29844859    Free PMC article.
Cetuximab combined with natural killer cells therapy: an alternative to chemoradiotherapy for patients with advanced non-small cell lung cancer (NSCLC).
Shuzhen Liang, Mao Lin, +6 authors, Jibing Chen.
Am J Cancer Res, 2018 Jun 12; 8(5). PMID: 29888109    Free PMC article.
An in Vitro Assay of hERG K Channel Potency for a New EGFR Inhibitor FHND004.
Tao Jin, Bingxue Hu, +5 authors, Zhao Zhang.
Front Pharmacol, 2018 Jun 16; 9. PMID: 29904349    Free PMC article.
Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.
Zhilian Li, Yan Li, +7 authors, Raymond C Harris.
Diabetes, 2018 Jul 01; 67(9). PMID: 29959129    Free PMC article.
Entinostat reverses P-glycoprotein activation in snail-overexpressing adenocarcinoma HCC827 cells.
Takumi Tomono, Tatsuya Machida, +3 authors, Takuo Ogihara.
PLoS One, 2018 Jul 07; 13(7). PMID: 29979729    Free PMC article.
Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells.
Jianfeng Huang, Xiaopeng Yuan, +6 authors, Fenju Liu.
Drug Des Devel Ther, 2018 Jul 25; 12. PMID: 30038488    Free PMC article.
Integrative omics analyses broaden treatment targets in human cancer.
Sohini Sengupta, Sam Q Sun, +18 authors, Li Ding.
Genome Med, 2018 Jul 29; 10(1). PMID: 30053901    Free PMC article.
EGFR may participate in immune evasion through regulation of B7‑H5 expression in non‑small cell lung carcinoma.
Zhaohui Dong, Lanying Zhang, Wei Xu, Gensheng Zhang.
Mol Med Rep, 2018 Aug 15; 18(4). PMID: 30106102    Free PMC article.
Caloric restriction inhibits mammary tumorigenesis in MMTV-ErbB2 transgenic mice through the suppression of ER and ErbB2 pathways and inhibition of epithelial cell stemness in premalignant mammary tissues.
Zhikun Ma, Amanda B Parris, +5 authors, Xiaohe Yang.
Carcinogenesis, 2018 Aug 15; 39(10). PMID: 30107476    Free PMC article.
Understanding the biology of HER3 receptor as a therapeutic target in human cancer.
Hui Lyu, Amy Han, +2 authors, Bolin Liu.
Acta Pharm Sin B, 2018 Aug 16; 8(4). PMID: 30109175    Free PMC article.
Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy.
Xiao-Mei Qi, Fang Wang, +2 authors, Guan Chen.
Acta Pharm Sin B, 2018 Aug 16; 8(4). PMID: 30109176    Free PMC article.
EGF Level in Hepatoid Gland Adenomas and Hepatoid Gland Epitheliomas in Dogs After Administering Tamoxifen.
Aleksandra Sobczyńska-Rak, Beata Żylińska, +2 authors, Marcin Tatara.
In Vivo, 2018 Aug 29; 32(5). PMID: 30150441    Free PMC article.
Possible Mechanisms of Green Tea and Its Constituents against Cancer.
Yohei Shirakami, Masahito Shimizu.
Molecules, 2018 Sep 13; 23(9). PMID: 30205425    Free PMC article.
Association between the overexpression of Her3 and clinical pathology and prognosis of colorectal cancer: A meta-analysis.
Qingying Yan, Kaibo Guo, +6 authors, Shanming Ruan.
Medicine (Baltimore), 2018 Sep 15; 97(37). PMID: 30212974    Free PMC article.
Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer.
Babak Nami, Hamid Maadi, Zhixiang Wang.
Cancers (Basel), 2018 Sep 23; 10(10). PMID: 30241301    Free PMC article.
Oncogenic Signaling Induced by HCV Infection.
Alessia Virzì, Armando Andres Roca Suarez, Thomas F Baumert, Joachim Lupberger.
Viruses, 2018 Oct 04; 10(10). PMID: 30279347    Free PMC article.
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
James A MacLeod, Yan Gao, +3 authors, Peter A Greer.
Oncotarget, 2018 Oct 04; 9(70). PMID: 30279968    Free PMC article.
The HER3 pathway as a potential target for inhibition in patients with biliary tract cancers.
Angela Lamarca, Salvatore Galdy, +9 authors, Juan W Valle.
PLoS One, 2018 Oct 20; 13(10). PMID: 30335866    Free PMC article.
TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation.
Gang Cai, Liang Zhu, +6 authors, Xiaoxia Li.
Proc Natl Acad Sci U S A, 2018 Oct 26; 115(45). PMID: 30352854    Free PMC article.
Estradiol promotes rapid degradation of HER3 in ER-positive breast cancer cell line MCF-7.
Junko Suga, Keiko Izumiyama, Nobuyuki Tanaka, Shigehira Saji.
Biochem Biophys Rep, 2018 Nov 13; 16. PMID: 30417127    Free PMC article.
A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases.
Ying-Nai Wang, Heng-Huan Lee, Mien-Chie Hung.
J Biomed Sci, 2018 Nov 20; 25(1). PMID: 30449278    Free PMC article.
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
Kanika Bajaj Pahuja, Thong T Nguyen, +31 authors, Somasekar Seshagiri.
Cancer Cell, 2018 Nov 20; 34(5). PMID: 30449325    Free PMC article.
HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.
Feifei Chen, Lei Zhang, +4 authors, Dongsheng Pei.
Cell Death Dis, 2018 Dec 07; 9(12). PMID: 30518879    Free PMC article.
Targeting tumor cells with antibodies enhances anti-tumor immunity.
Zhichen Sun, Yang-Xin Fu, Hua Peng.
Biophys Rep, 2018 Dec 12; 4(5). PMID: 30533489    Free PMC article.
Cell Biology of Intracellular Adaptation of Mycobacterium leprae in the Peripheral Nervous System.
Samuel Hess, Anura Rambukkana.
Microbiol Spectr, 2019 Jul 20; 7(4). PMID: 31322104    Free PMC article.
Targeting the EGFR and Immune Pathways in Squamous Cell Carcinoma of the Head and Neck (SCCHN): Forging a New Alliance.
Nabil F Saba, Zhuo Gerogia Chen, +8 authors, Alfio Ferlito.
Mol Cancer Ther, 2019 Nov 05; 18(11). PMID: 31676542    Free PMC article.
Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.
Joan Montero, Cécile Gstalder, +12 authors, Rizwan Haq.
Nat Commun, 2019 Nov 16; 10(1). PMID: 31727958    Free PMC article.
The Landscape of Actionable Gene Fusions in Colorectal Cancer.
Filippo Pagani, Giovanni Randon, +8 authors, Filippo Pietrantonio.
Int J Mol Sci, 2019 Nov 17; 20(21). PMID: 31731495    Free PMC article.
Epidermal growth factor receptor first generation tyrosine-kinase inhibitors.
Alex Martinez-Marti, Alejandro Navarro, Enriqueta Felip.
Transl Lung Cancer Res, 2019 Dec 21; 8(Suppl 3). PMID: 31857948    Free PMC article.
The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.
Z Huang, B-K Choi, +6 authors, Z An.
Oncogene, 2014 Mar 26; 34(9). PMID: 24662824
Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers.
Bowen Sun, Seth Mason, +9 authors, Qi Wang.
Oncogene, 2019 Aug 30; 39(1). PMID: 31462705    Free PMC article.
KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan.
Muhammad Awidi, Nidaa Ababneh, +5 authors, Abdalla Awidi.
PLoS One, 2019 Dec 28; 14(12). PMID: 31881025    Free PMC article.
The prognostic value of tumor mutation burden in EGFR-mutant advanced lung adenocarcinoma, an analysis based on cBioPortal data base.
Xiao-Dong Jiao, Xi He, +5 authors, Yuan-Sheng Zang.
J Thorac Dis, 2020 Jan 07; 11(11). PMID: 31903239    Free PMC article.
Value of CagA, HER2, ALDH1, and KiSS-1 in predicting metastasis and prognosis for gastric adenocarcinoma.
Guoyu Lu, Xiaolin Wang, +2 authors, Lei Zhou.
Int J Clin Exp Pathol, 2018 Jul 01; 11(7). PMID: 31949743    Free PMC article.
Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody-Antigen Binding on Live Cells.
Thomas Bridge, Saher A Shaikh, +3 authors, Amit Sachdeva.
Angew Chem Int Ed Engl, 2019 Oct 15; 58(50). PMID: 31609054    Free PMC article.
Neuropeptide bombesin receptor activation stimulates growth of lung cancer cells through HER3 with a MAPK-dependent mechanism.
Lingaku Lee, Irene Ramos-Alvarez, +2 authors, Robert T Jensen.
Biochim Biophys Acta Mol Cell Res, 2019 Dec 22; 1867(4). PMID: 31862538    Free PMC article.
Targeting the Sphingolipid System as a Therapeutic Direction for Glioblastoma.
Melinda N Tea, Santosh I Poonnoose, Stuart M Pitson.
Cancers (Basel), 2020 Jan 08; 12(1). PMID: 31906280    Free PMC article.
Targeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro.
Chandra Kumar Elechalawar, Md Nazir Hossen, +5 authors, Priyabrata Mukherjee.
Int J Nanomedicine, 2020 Feb 28; 15. PMID: 32103952    Free PMC article.
Dacomitinib, but not lapatinib, suppressed progression in castration-resistant prostate cancer models by preventing HER2 increase.
Maitreyee K Jathal, Thomas M Steele, +5 authors, Paramita M Ghosh.
Br J Cancer, 2019 Jun 19; 121(3). PMID: 31209328    Free PMC article.
A compact synthetic pathway rewires cancer signaling to therapeutic effector release.
Hokyung K Chung, Xinzhi Zou, +5 authors, Michael Z Lin.
Science, 2019 May 03; 364(6439). PMID: 31048459    Free PMC article.
Modulation of Immune Responses by Platelet-Derived ADAM10.
Stefanie Maurer, Hans-Georg Kopp, Helmut R Salih, Korbinian N Kropp.
Front Immunol, 2020 Mar 03; 11. PMID: 32117229    Free PMC article.
Cucurbitacin D Overcomes Gefitinib Resistance by Blocking EGF Binding to EGFR and Inducing Cell Death in NSCLCs.
Se Hyang Hong, Jin Mo Ku, +4 authors, Seong-Gyu Ko.
Front Oncol, 2020 Mar 07; 10. PMID: 32133284    Free PMC article.
Rates of ERBB2 Alterations across Melanoma Subtypes and a Complete Response to Trastuzumab Emtansine in an ERBB2-Amplified Acral Melanoma.
Lee S Gottesdiener, Shannon O'Connor, +4 authors, Alexander N Shoushtari.
Clin Cancer Res, 2018 Aug 11; 24(23). PMID: 30093446    Free PMC article.
Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion.
Rui Wang, Rajat Bhattacharya, +3 authors, Lee M Ellis.
Mol Cancer Res, 2018 Aug 23; 17(1). PMID: 30131447    Free PMC article.
Crosstalk between TF/FVIIa and EGFR signaling in colorectal cancer cells.
He-Kai Chen, Xin Wang, Yuan-Lian Wan, Jian-Qiang Tang.
Cancer Biol Ther, 2018 Nov 22; 20(4). PMID: 30462558    Free PMC article.
Targeting HER2 in patient-derived xenograft ovarian cancer models sensitizes tumors to chemotherapy.
Faye R Harris, Piyan Zhang, +5 authors, Irina V Kovtun.
Mol Oncol, 2018 Dec 01; 13(2). PMID: 30499260    Free PMC article.
Efficacy and safety of osimertinib in treating EGFR-mutated advanced NSCLC: A meta-analysis.
Lilan Yi, Junsheng Fan, +2 authors, Jian Zhang.
Int J Cancer, 2019 Jan 08; 145(1). PMID: 30613959    Free PMC article.
Systematic Review.
A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives.
Daniel Nascimento do Amaral, Jonas Lategahn, +6 authors, Lidia Moreira Lima.
Sci Rep, 2019 Jan 11; 9(1). PMID: 30626888    Free PMC article.
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.
Lindsay Kosack, Bettina Wingelhofer, +25 authors, Andreas Bergthaler.
Cancer Cell, 2019 Jan 16; 35(1). PMID: 30645971    Free PMC article.
Genetic Analyses Confirm SNPs in HSPA8 and ERBB2 are Associated with Milk Protein Concentration in Chinese Holstein Cattle.
Cong Li, Miao Wang, +5 authors, Shengli Zhang.
Genes (Basel), 2019 Feb 02; 10(2). PMID: 30704154    Free PMC article.
DNAzyme Catalyzed Tyramide Depositing Reaction for In Situ Imaging of Protein Status on the Cell Surface.
Lulu Xu, Shengchun Liu, +7 authors, Wei Cheng.
Theranostics, 2019 May 01; 9(7). PMID: 31037152    Free PMC article.
Bisphenol AF promotes estrogen receptor-positive breast cancer cell proliferation through amphiregulin-mediated crosstalk with receptor tyrosine kinase signaling.
Qingxia Zhao, Erin W Howard, +3 authors, Xiaohe Yang.
PLoS One, 2019 May 07; 14(5). PMID: 31059536    Free PMC article.
Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo.
Veronika Ramovs, Pablo Secades, +3 authors, Arnoud Sonnenberg.
Breast Cancer Res, 2019 May 19; 21(1). PMID: 31101121    Free PMC article.
The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.
Adam D Pfefferle, David B Darr, +3 authors, Charles M Perou.