. 2005 May; 4(3):283-93.
doi: 10.1177/153303460500400308.

A review of progress in clinical photodynamic therapy

Z Huang 1 
  • PMID: 15896084
  •     123 References
  •     171 citations


Photodynamic therapy (PDT) has received increased attention since the regulatory approvals have been granted to several photosensitizing drugs and light applicators worldwide. Much progress has been seen in basic sciences and clinical photodynamics in recent years. This review will focus on new developments of clinical investigation and discuss the usefulness of various forms of PDT techniques for curative or palliative treatment of malignant and non-malignant diseases.

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Circulation, 2000 Nov 09; 102(19). PMID: 11067782
Survival after photodynamic therapy to non-pulmonary metastatic endobronchial tumors.
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Lasers Surg Med, 1999 May 06; 24(3). PMID: 10229150
Topical 5-ALA photodynamic therapy for the treatment of cutaneous T-cell lymphoma.
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Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer.
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Evaluation of photodynamic therapy near functional brain tissue in patients with recurrent brain tumors.
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Effect of photodynamic therapy on recurrent pituitary adenomas: clinical phase I/II trial--an early report.
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Br J Neurosurg, 2000 Oct 25; 14(4). PMID: 11045196
Photodynamic therapy in Barrett's esophagus.
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Gastrointest Endosc Clin N Am, 2003 Nov 25; 13(3). PMID: 14629104
Photodynamic therapy: a novel treatment for primary brain malignancy.
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Clinical experience with 5-aminolevulinic acid and photodynamic therapy for refractory superficial bladder cancer.
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Curr Opin Pulm Med, 2004 Jun 29; 10(4). PMID: 15220748
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J Urol, 1998 Jun 17; 160(1). PMID: 9628601
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Highly Cited.
Meta-tetra(hydroxyphenyl)chlorin photodynamic therapy in early-stage squamous cell carcinoma of the head and neck.
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Arch Otolaryngol Head Neck Surg, 2003 Jul 23; 129(7). PMID: 12874068
Photodynamic therapy for carcinoma in situ of the anus.
John Webber, David Fromm.
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Gastrointest Endosc, 2005 Jan 27; 61(1). PMID: 15672050
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Studies expand potential uses of photodynamic therapy.
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J Natl Cancer Inst, 2002 Dec 05; 94(23). PMID: 12464643
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Ophthalmol Clin North Am, 2003 Jan 08; 15(4). PMID: 12515080
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A multicenter Phase I safety study of intratumoral photoactivation of talaporfin sodium in patients with refractory solid tumors.
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Highly Cited. Review.
5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (review).
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Int J Oncol, 2002 Aug 09; 21(3). PMID: 12168102
Topical aminolevulinic acid HCl photodynamic therapy.
D Ormrod, B Jarvis.
Am J Clin Dermatol, 2001 Nov 13; 1(2). PMID: 11702313
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Clinical outcomes of photodynamic therapy for head-and-neck cancer.
Pei-Jen Lou, Linda Jones, Colin Hopper.
Technol Cancer Res Treat, 2003 Aug 02; 2(4). PMID: 12892513
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Ron R Allison, Gordon H Downie, +3 authors, Claudio H Sibata.
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Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma.
C A Morton, C Whitehurst, +2 authors, R M MacKie.
Arch Dermatol, 2001 Mar 20; 137(3). PMID: 11255332
Photodynamic therapy of circumscribed choroidal haemangioma.
A D Singh, P K Kaiser, +3 authors, I G Rennie.
Br J Ophthalmol, 2004 Oct 19; 88(11). PMID: 15489484    Free PMC article.
A randomised, double-blind, placebo-controlled trial of photodynamic therapy using 5-aminolaevulinic acid for the treatment of cervical intraepithelial neoplasia.
Adrian A Barnett, J Christoph Haller, +3 authors, David J H Roberts.
Int J Cancer, 2003 Jan 08; 103(6). PMID: 12516106
Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer.
Zheng Huang, Qun Chen, +6 authors, Fred W Hetzel.
Lasers Surg Med, 2005 Apr 28; 36(5). PMID: 15856509    Free PMC article.
Optimization of multifiber light delivery for the photodynamic therapy of localized prostate cancer.
C Whitehurst, M L Pantelides, J V Moore, N J Blacklock.
Photochem Photobiol, 1993 Oct 01; 58(4). PMID: 8248336
Whole bladder photodynamic therapy with 5-aminolevulinic acid using a white light source.
R Waidelich, W Beyer, +5 authors, M Kriegmair.
Urology, 2003 Feb 25; 61(2). PMID: 12597941
Preoperative laser photodynamic therapy in combination with operation in lung cancer.
H Kato, C Konaka, +7 authors, T Kito.
J Thorac Cardiovasc Surg, 1985 Sep 01; 90(3). PMID: 3162068
mTHPC-mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study of 128 patients.
Anil K D'Cruz, Martin H Robinson, Merrill A Biel.
Head Neck, 2004 Mar 05; 26(3). PMID: 14999798
Lasers and light sources for PDT: past, present and future.
Thomas S Mang.
Photodiagnosis Photodyn Ther, 2004 May 01; 1(1). PMID: 25048063
Photodynamic therapy with systemic administration of photosensitizers in dermatology.
P G Calzavara-Pinton, R M Szeimies, B Ortel, C Zane.
J Photochem Photobiol B, 1996 Nov 01; 36(2). PMID: 9002266
Metronomic photodynamic therapy as a new paradigm for photodynamic therapy: rationale and preclinical evaluation of technical feasibility for treating malignant brain tumors.
Stuart K Bisland, Lothar Lilge, +2 authors, Brian C Wilson.
Photochem Photobiol, 2004 Sep 02; 80. PMID: 15339204
mTHPC-mediated photodynamic diagnosis of malignant brain tumors.
A Zimmermann, M Ritsch-Marte, H Kostron.
Photochem Photobiol, 2001 Oct 31; 74(4). PMID: 11683042
Improvement of tumor response by manipulation of tumor oxygenation during photodynamic therapy.
Qun Chen, Zheng Huang, +3 authors, Fred W Hetzel.
Photochem Photobiol, 2002 Aug 27; 76(2). PMID: 12194217
Photodynamic therapy of endobronchial tumors.
J S McCaughan, T E Williams, B H Bethel.
Lasers Surg Med, 1986 Jan 01; 6(3). PMID: 2942745
Photodynamic therapy for mesothelioma.
S M Hahn, R P Smith, J Friedberg.
Curr Treat Options Oncol, 2002 Jun 12; 2(5). PMID: 12057100
Topical photodynamic therapy for patients with therapy-resistant lesions of cutaneous T-cell lymphoma.
Esther A Coors, Peter von den Driesch.
J Am Acad Dermatol, 2004 Feb 28; 50(3). PMID: 14988676
Photodynamic therapy for superficial bladder cancer under local anaesthetic.
D C Shackley, C Briggs, +5 authors, N W Clarke.
BJU Int, 2002 Apr 23; 89(7). PMID: 11966622
Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light.
T J Dougherty, G B Grindey, +2 authors, D G Boyle.
J Natl Cancer Inst, 1975 Jul 01; 55(1). PMID: 1159805
Highly Cited.
New light on the brain: The role of photosensitizing agents and laser light in the management of invasive intracranial tumors.
M Sam Eljamel.
Technol Cancer Res Treat, 2003 Aug 02; 2(4). PMID: 12892512
Photodynamic therapy in cholangiocarcinoma: an overview.
Maria-Anna Ortner.
Photodiagnosis Photodyn Ther, 2004 May 01; 1(1). PMID: 25048068
Early clinical experience with 5-aminolevulinic acid for the photodynamic therapy of superficial bladder cancer.
M Kriegmair, R Baumgartner, +2 authors, A Hofstetter.
Br J Urol, 1996 May 01; 77(5). PMID: 8689107
Photodynamic therapy for palliation of locally recurrent breast carcinoma.
M Schuh, U O Nseyo, +2 authors, T J Dougherty.
J Clin Oncol, 1987 Nov 01; 5(11). PMID: 2445930
Interstitial photodynamic therapy for prostate cancer: a developing modality.
Neil E Martin, Stephen M Hahn.
Photodiagnosis Photodyn Ther, 2004 Sep 01; 1(2). PMID: 25048183
Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung.
Harubumi Kato, Kinya Furukawa, +9 authors, Hirohisa Horinouchi.
Lung Cancer, 2003 Sep 27; 42(1). PMID: 14512194
Photodynamic therapy for cholangiocarcinoma.
Frieder Berr.
Semin Liver Dis, 2004 Jun 12; 24(2). PMID: 15192790
The present and future role of photodynamic therapy in cancer treatment.
Stanley B Brown, Elizabeth A Brown, Ian Walker.
Lancet Oncol, 2004 Aug 04; 5(8). PMID: 15288239
Highly Cited. Review.
Improved response of plaque psoriasis after multiple treatments with topical 5-aminolaevulinic acid photodynamic therapy.
D J Robinson, P Collins, +4 authors, R A Sheehan-Dare.
Acta Derm Venereol, 1999 Dec 22; 79(6). PMID: 10598759
Photodynamic therapy (PDT) of lung cancer: experience of the Tokyo Medical University.
Harubumi Kato, Masahiko Harada, +3 authors, Tetsuya Okunaka.
Photodiagnosis Photodyn Ther, 2004 May 01; 1(1). PMID: 25048064
Treatment of sebaceous gland hyperplasia by photodynamic therapy with 5-aminolevulinic acid and a blue light source or intense pulsed light source.
Michael H Gold, Virginia L Bradshaw, +3 authors, Tammy L Lewis.
J Drugs Dermatol, 2004 Dec 31; 3(6 Suppl). PMID: 15624735
General principles of photodynamic therapy (PDT) and gastrointestinal applications.
Marcus W Wiedmann, Karel Caca.
Curr Pharm Biotechnol, 2004 Aug 24; 5(4). PMID: 15320770
Interstitial photodynamic laser therapy in interventional oncology.
Thomas J Vogl, Katrin Eichler, +4 authors, Kerstin Engelmann.
Eur Radiol, 2004 Mar 27; 14(6). PMID: 15045520
Hematoporphyrin derivative: a new aid for endoscopic detection of malignant disease.
J Thorac Cardiovasc Surg, 1961 Nov 01; 42. PMID: 14465760
Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy.
Asta Juzeniene, Petras Juzenas, +2 authors, Johan Moan.
Lasers Med Sci, 2004 Oct 27; 19(3). PMID: 15503248
A multispectral fluorescence imaging system: design and initial clinical tests in intra-operative Photofrin-photodynamic therapy of brain tumors.
Victor X D Yang, Paul J Muller, Peter Herman, Brian C Wilson.
Lasers Surg Med, 2003 Feb 28; 32(3). PMID: 12605430
Photodynamic therapy enhanced by hyperbaric oxygenation in palliation of malignant pleural mesothelioma: clinical experience.
Veronika Matzi, Alfred Maier, +4 authors, Freyja Maria Smolle-Jüttner.
Photodiagnosis Photodyn Ther, 2004 May 01; 1(1). PMID: 25048065
Photodynamic therapy for pancreatic and biliary tract carcinoma.
Lakshmana Ayaru, Stephen G Bown, Stephen P Pereira.
Int J Gastrointest Cancer, 2005 Feb 22; 35(1). PMID: 15722569
Photodynamic ablation of early cancers of the stomach by means of mTHPC and laser irradiation: preliminary clinical experience.
C Ell, L Gossner, +4 authors, R Sroka.
Gut, 1998 Dec 24; 43(3). PMID: 9863479    Free PMC article.
Light-emitting diodes as a light source for intraoperative photodynamic therapy.
M H Schmidt, D M Bajic, +3 authors, H T Whelan.
Neurosurgery, 1996 Mar 01; 38(3). PMID: 8837808
Rostaporfin (Miravant Medical Technologies).
David W C Hunt.
IDrugs, 2003 Jul 16; 5(2). PMID: 12861479
Preclinical studies in normal canine prostate of a novel palladium-bacteriopheophorbide (WST09) photosensitizer for photodynamic therapy of prostate cancers.
Qun Chen, Zheng Huang, +6 authors, Fred W Hetzel.
Photochem Photobiol, 2002 Oct 31; 76(4). PMID: 12405153
Intraoperative photodynamic therapy after pleuropneumonectomy for malignant pleural mesothelioma.
Pierre Bonnette, Genevieve Bourg Heckly, Sandrine Villette, Alexandra Fragola.
Chest, 2002 Nov 12; 122(5). PMID: 12426299
Techniques for delivery and monitoring of TOOKAD (WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities.
Robert A Weersink, Arjen Bogaards, +5 authors, Brian C Wilson.
J Photochem Photobiol B, 2005 May 18; 79(3). PMID: 15896648
Fluorescence-guided resections of malignant gliomas--an overview.
W Stummer, H J Reulen, +2 authors, J C Tonn.
Acta Neurochir Suppl, 2003 Oct 09; 88. PMID: 14531555
Recalcitrant hand and foot warts successfully treated with photodynamic therapy with topical 5-aminolaevulinic acid: a pilot study.
I M Stender, J Lock-Andersen, H C Wulf.
Clin Exp Dermatol, 1999 Jun 03; 24(3). PMID: 10354167
Photodynamic therapy in patients with non-resectable hilar cholangiocarcinoma: 5-year follow-up of a prospective phase II study.
Marcus Wiedmann, Frieder Berr, +4 authors, Karel Caca.
Gastrointest Endosc, 2004 Jul 02; 60(1). PMID: 15229428
Photodynamic therapy in oncology.
C H Sibata, V C Colussi, N L Oleinick, T J Kinsella.
Expert Opin Pharmacother, 2001 Oct 05; 2(6). PMID: 11585008
The effect of transurethral light on the canine prostate after sensitization with the photosensitizer tin (II) etiopurpurin dichloride: a pilot study.
S H Selman, R W Keck.
J Urol, 1994 Dec 01; 152(6 Pt 1). PMID: 7966701
Photodynamic therapy for chest wall recurrence in breast cancer.
P W Sperduto, T F DeLaney, +5 authors, E Glatstein.
Int J Radiat Oncol Biol Phys, 1991 Jul 01; 21(2). PMID: 2061120
Photodynamic therapy of locoregional breast cancer recurrences using a chlorin-type photosensitizer.
P Wyss, V Schwarz, +4 authors, M Fehr.
Int J Cancer, 2001 Jul 31; 93(5). PMID: 11477585
Hyperoxygenation enhances the tumor cell killing of photofrin-mediated photodynamic therapy.
Zheng Huang, Qun Chen, +4 authors, Fred W Hetzel.
Photochem Photobiol, 2003 Dec 05; 78(5). PMID: 14653582
Effects of Pd-bacteriopheophorbide (TOOKAD)-mediated photodynamic therapy on canine prostate pretreated with ionizing radiation.
Zheng Huang, Qun Chen, +5 authors, Fred W Hetzel.
Radiat Res, 2004 May 27; 161(6). PMID: 15161347    Free PMC article.
New technology for deep light distribution in tissue for phototherapy.
James Chen, Llew Keltner, +4 authors, Sy-shi Wang.
Cancer J, 2002 May 10; 8(2). PMID: 11999949
Current clinical and preclinical photosensitizers for use in photodynamic therapy.
Michael R Detty, Scott L Gibson, Stephen J Wagner.
J Med Chem, 2004 Jul 23; 47(16). PMID: 15267226
Phase I drug and light dose-escalation trial of motexafin lutetium and far red light activation (phototherapy) in subjects with coronary artery disease undergoing percutaneous coronary intervention and stent deployment: procedural and long-term results.
Dean J Kereiakes, Arthur M Szyniszewski, +13 authors, Daniel C Adelman.
Circulation, 2003 Aug 27; 108(11). PMID: 12939212
Photodynamic therapy for peripheral lung cancer.
Tetsuya Okunaka, Harubumi Kato, +3 authors, Yukari Kuroiwa.
Lung Cancer, 2003 Dec 31; 43(1). PMID: 14698541
Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization.
Ana P Castano, Tatiana N Demidova, Michael R Hamblin.
Photodiagnosis Photodyn Ther, 2004 Dec 01; 1(4). PMID: 25048432    Free PMC article.
Highly Cited.
Phase I trial of photodynamic therapy in the treatment of recurrent superficial transitional cell carcinoma of the bladder.
M M Walther, T F Delaney, +9 authors, E Glatstein.
Urology, 1997 Aug 01; 50(2). PMID: 9255289
Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma.
Gavin C Harewood, Todd H Baron, +4 authors, Piet C de Groen.
J Gastroenterol Hepatol, 2005 Mar 03; 20(3). PMID: 15740486
Photodynamic therapy of high-grade cervical intraepithelial neoplasia with 5-aminolevulinic acid.
Kristin A Keefe, Yona Tadir, +4 authors, Bradley J Monk.
Lasers Surg Med, 2002 Oct 02; 31(4). PMID: 12355576
Photodynamic therapy for refractory superficial bladder cancer: long-term clinical outcomes of single treatment using intravesical diffusion medium.
Michael J Manyak, Kenneth Ogan.
J Endourol, 2003 Nov 19; 17(8). PMID: 14622483
Verteporfin therapy in age-related macular degeneration (VAM): an open-label multicenter photodynamic therapy study of 4,435 patients.
Neil M Bessler, Vam Study Writing Committee.
Retina, 2004 Aug 10; 24(4). PMID: 15300071
Targeted optical imaging and photodynamic therapy.
N Solban, B Ortel, B Pogue, T Hasan.
Ernst Schering Res Found Workshop, 2004 Nov 05; (49). PMID: 15524219
Intracellular signaling mechanisms in photodynamic therapy.
Ramiro D Almeida, Bruno J Manadas, Arsélio P Carvalho, Carlos B Duarte.
Biochim Biophys Acta, 2004 Sep 15; 1704(2). PMID: 15363861
Photodynamic therapy and the treatment of head and neck neoplasia.
M A Biel.
Laryngoscope, 1998 Sep 17; 108(9). PMID: 9738739
Effects of photodynamic therapy on peripheral nerve: in situ compound-action potentials study in a canine model.
Kenneth C Dole, Qun Chen, +3 authors, Zhen Huang.
Photomed Laser Surg, 2005 May 25; 23(2). PMID: 15910181    Free PMC article.
Photodynamic therapy of sebaceous hyperplasia with topical 5-aminolaevulinic acid and slide projector.
T Horio, O Horio, +2 authors, T Isei.
Br J Dermatol, 2003 Jun 28; 148(6). PMID: 12828768
Photodynamic therapy for cancer of the pancreas.
S G Bown, A Z Rogowska, +7 authors, A W R Hatfield.
Gut, 2002 Mar 13; 50(4). PMID: 11889078    Free PMC article.
Adjuvant photodynamic therapy for bile duct carcinoma after surgery: a preliminary study.
Atsushi Nanashima, Hiroyuki Yamaguchi, +7 authors, Takeshi Nagayasu.
J Gastroenterol, 2004 Dec 08; 39(11). PMID: 15580404
Primary clinical response and long-term follow-up of solar keratoses treated with topically applied 5-aminolevulinic acid and irradiation by different wave bands of light.
R Fink-Puches, A Hofer, +2 authors, P Wolf.
J Photochem Photobiol B, 1998 Jan 24; 41(1-2). PMID: 9440322
Verteporfin : a review of its use in the management of subfoveal choroidal neovascularisation.
Susan J Keam, Lesley J Scott, Monique P Curran.
Drugs, 2003 Nov 12; 63(22). PMID: 14609361
Interstitial photodynamic therapy. Clinical experience with diffusing fibres in the treatment of cutaneous and subcutaneous tumours.
C P Lowdell, D V Ash, I Driver, S B Brown.
Br J Cancer, 1993 Jun 01; 67(6). PMID: 8512824    Free PMC article.
Neoadjuvant photodynamic therapy as a new approach to treating hilar cholangiocarcinoma: a phase II pilot study.
Marcus Wiedmann, Karel Caca, +6 authors, Helmut Witzigmann.
Cancer, 2003 May 27; 97(11). PMID: 12767091
Photoimmunotherapy for cancer treatment.
Wei R Chen, Zheng Huang, +2 authors, Hong Liu.
J Environ Pathol Toxicol Oncol, 2006 Mar 29; 25(1-2). PMID: 16566724
Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death.
Ana P Castano, Tatiana N Demidova, Michael R Hamblin.
Photodiagnosis Photodyn Ther, 2005 Mar 01; 2(1). PMID: 25048553    Free PMC article.
Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study.
Marianne E J Ortner, Karel Caca, +7 authors, Herbert Lochs.
Gastroenterology, 2003 Nov 05; 125(5). PMID: 14598251
Highly Cited.
Photodynamic therapy with intravesical instillation of 5-aminolevulinic acid for patients with recurrent superficial bladder cancer: a single-center study.
Andreas P Berger, Hannes Steiner, +3 authors, Lorenz Holtl.
Urology, 2003 Feb 25; 61(2). PMID: 12597942
[Photodynamic therapy (PDT) for early cervical cancer].
T Muroya, Y Suehiro, +6 authors, Y Tenjin.
Gan To Kagaku Ryoho, 1996 Jan 01; 23(1). PMID: 8546469
Longer term assessment of photodynamic therapy for intimal hyperplasia: a pilot study.
Justin Cheung, Mary Todd, +5 authors, York Hsiang.
J Photochem Photobiol B, 2004 Feb 21; 73(3). PMID: 14975402
Magnetic resonance imaging correlated with the histopathological effect of Pd-bacteriopheophorbide (Tookad) photodynamic therapy on the normal canine prostate gland.
Zheng Huang, Masoom A Haider, +4 authors, Fred W Hetzel.
Lasers Surg Med, 2006 Jun 27; 38(7). PMID: 16799982    Free PMC article.
Potentiation of photodynamic therapy of cancer by complement: the effect of gamma-inulin.
M Korbelik, P D Cooper.
Br J Cancer, 2006 Dec 06; 96(1). PMID: 17146472    Free PMC article.
Polymer platforms for drug delivery and biomedical imaging.
Zheng-Rong Lu, Furong Ye, Anagha Vaidya.
J Control Release, 2007 Jul 31; 122(3). PMID: 17662500    Free PMC article.
Photodynamic therapy-generated vaccines: relevance of tumour cell death expression.
M Korbelik, B Stott, J Sun.
Br J Cancer, 2007 Nov 01; 97(10). PMID: 17971767    Free PMC article.
The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues--in vivo study in a canine model.
Zheng Huang, Qun Chen, +5 authors, Fred W Hetzel.
Photochem Photobiol Sci, 2007 Nov 30; 6(12). PMID: 18046488    Free PMC article.
Combination of photodynamic therapy and immunomodulation: current status and future trends.
Yong-Gang Qiang, Christine M N Yow, Zheng Huang.
Med Res Rev, 2007 Dec 29; 28(4). PMID: 18161883    Free PMC article.
Photodynamic therapy for treatment of solid tumors--potential and technical challenges.
Zheng Huang, Heping Xu, +5 authors, Yang K Chen.
Technol Cancer Res Treat, 2008 Jul 23; 7(4). PMID: 18642969    Free PMC article.
Self-expandable metal stents and trans-stent light delivery: are metal stents and photodynamic therapy compatible?
Luo-Wei Wang, Li-Bo Li, +3 authors, Zheng Huang.
Lasers Surg Med, 2008 Oct 28; 40(9). PMID: 18951422    Free PMC article.
Effect of photodynamic therapy on the healing of cutaneous third-degree-burn: histological study in rats.
Valdir Gouveia Garcia, Marcos Alcântara de Lima, +5 authors, Letícia Helena Theodoro.
Lasers Med Sci, 2009 Jun 18; 25(2). PMID: 19533211
Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models.
Kimberley S Samkoe, Alina Chen, +5 authors, Brian W Pogue.
Int J Radiat Oncol Biol Phys, 2009 Dec 17; 76(1). PMID: 20005458    Free PMC article.
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine.
Nicola J Farrer, Luca Salassa, Peter J Sadler.
Dalton Trans, 2009 Dec 22; (48). PMID: 20023896    Free PMC article.
Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.
Jonathan P Celli, Bryan Q Spring, +5 authors, Tayyaba Hasan.
Chem Rev, 2010 Apr 01; 110(5). PMID: 20353192    Free PMC article.
Highly Cited. Review.
Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy.
Soroush Merchant, Mladen Korbelik.
Cell Stress Chaperones, 2010 Sep 25; 16(2). PMID: 20865355    Free PMC article.
In-body optical stimulation formed connective tissue vascular grafts, "biotubes," with many capillaries and elastic fibers.
Tomonori Oie, Masashi Yamanami, +3 authors, Yasuhide Nakayama.
J Artif Organs, 2010 Oct 01; 13(4). PMID: 20882309
Quenching enhancement of the singlet excited state of pheophorbide-a by DNA in the presence of the quinone carboquone.
Yisaira Díaz-Espinosa, Carlos E Crespo-Hernández, +2 authors, Rafael Arce.
Photochem Photobiol, 2010 Dec 09; 87(2). PMID: 21138440    Free PMC article.
Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response.
Pawel Mroz, Angelika Szokalska, Mei X Wu, Michael R Hamblin.
PLoS One, 2010 Dec 24; 5(12). PMID: 21179470    Free PMC article.
Selective imaging and killing of cancer cells with protein-activated near-infrared fluorescing nanoparticles.
Parul Rungta, Yuriy P Bandera, +6 authors, Stephen H Foulger.
Macromol Biosci, 2011 Apr 12; 11(7). PMID: 21480531    Free PMC article.
Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo.
Diane E Marotta, Weiguo Cao, +7 authors, Theresa M Busch.
Nanomedicine (Lond), 2011 May 06; 6(3). PMID: 21542686    Free PMC article.
Syntheses and cellular investigations of 17(3)-, 15(2)-, and 13(1)-amino acid derivatives of chlorin e(6).
R G Waruna Jinadasa, Xiaoke Hu, M Graça H Vicente, Kevin M Smith.
J Med Chem, 2011 Sep 23; 54(21). PMID: 21936519    Free PMC article.
Syntheses and properties of trimethylaminophenoxy-substituted Zn((II))-phthalocyanines.
Benson G Ongarora, Xiaoke Hu, +2 authors, M Graça H Vicente.
Medchemcomm, 2012 Feb 07; 3(2). PMID: 22308216    Free PMC article.
Treatment of experimental periodontitis in rats using repeated adjunctive antimicrobial photodynamic therapy.
Valdir Gouveia Garcia, Mariéllen Longo, +5 authors, Letícia Helena Theodoro.
Lasers Med Sci, 2012 Apr 25; 28(1). PMID: 22526974
Characterization of a conjugate between Rose Bengal and chitosan for targeted antibiofilm and tissue stabilization effects as a potential treatment of infected dentin.
Annie Shrestha, Michael R Hamblin, Anil Kishen.
Antimicrob Agents Chemother, 2012 Jul 11; 56(9). PMID: 22777042    Free PMC article.
Shedding light on nanomedicine.
Rong Tong, Daniel S Kohane.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2012 Aug 14; 4(6). PMID: 22887840    Free PMC article.
Shining light on nanotechnology to help repair and regeneration.
Asheesh Gupta, Pinar Avci, +7 authors, Michael R Hamblin.
Biotechnol Adv, 2012 Sep 07; 31(5). PMID: 22951919    Free PMC article.
Syntheses and Photodynamic Activity of Pegylated Cationic Zn(II)-Phthalocyanines in HEp2 Cells.
Benson G Ongarora, Xiaoke Hu, +2 authors, M Graça H Vicente.
Theranostics, 2012 Oct 20; 2(9). PMID: 23082098    Free PMC article.
Synthesis and cellular studies of polyamine conjugates of a mercaptomethyl-carboranylporphyrin.
N V S Dinesh K Bhupathiraju, M Graça H Vicente.
Bioorg Med Chem, 2012 Dec 12; 21(2). PMID: 23219853    Free PMC article.
Enhanced antitumor activity of the photosensitizer meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles.
Sharif M Abdelghany, Daniela Schmid, +8 authors, Christopher J Scott.
Biomacromolecules, 2013 Jan 19; 14(2). PMID: 23327610    Free PMC article.
PDT dose parameters impact tumoricidal durability and cell death pathways in a 3D ovarian cancer model.
Imran Rizvi, Sriram Anbil, +7 authors, Tayyaba Hasan.
Photochem Photobiol, 2013 Feb 28; 89(4). PMID: 23442192    Free PMC article.
Photodynamic nanomedicine in the treatment of solid tumors: perspectives and challenges.
Alyssa Master, Megan Livingston, Anirban Sen Gupta.
J Control Release, 2013 Mar 12; 168(1). PMID: 23474028    Free PMC article.
A cell-targeted photodynamic nanomedicine strategy for head and neck cancers.
Alyssa Master, Anthony Malamas, +3 authors, Anirban Sen Gupta.
Mol Pharm, 2013 Mar 28; 10(5). PMID: 23531079    Free PMC article.
Optical profiles of cathode ray tube and liquid crystal display monitors: implication in cutaneous phototoxicity in photodynamic therapy.
Tim C Lei, Srinivas Pendyala, +3 authors, Zheng Huang.
Appl Opt, 2013 May 15; 52(12). PMID: 23669681    Free PMC article.
Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction.
Helin Räägel, Margot Hein, +4 authors, Margus Pooga.
Cell Mol Life Sci, 2013 Jul 16; 70(24). PMID: 23852439
Spectroscopic, computational modeling and cytotoxicity of a series of meso-phenyl and meso-thienyl-BODIPYs.
Jaime H Gibbs, Larry T Robins, +5 authors, M Graça H Vicente.
Bioorg Med Chem, 2013 Aug 10; 21(18). PMID: 23928070    Free PMC article.
Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells.
Luo-Wei Wang, Zheng Huang, +3 authors, Bolin Liu Md.
Photodiagnosis Photodyn Ther, 2013 Sep 03; 10(3). PMID: 23993850    Free PMC article.
Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen.
E Reginato, P Mroz, +3 authors, M R Hamblin.
Br J Cancer, 2013 Sep 26; 109(8). PMID: 24064977    Free PMC article.
Carboplatin synergistically triggers the efficacy of photodynamic therapy via caspase 3-, 8-, and 12-dependent pathways in human anaplastic thyroid cancer cells.
Raktim Biswas, Phil-Sang Chung, +2 authors, Jin-Chul Ahn.
Lasers Med Sci, 2013 Oct 12; 29(3). PMID: 24114422
A novel tumor targeting drug carrier for optical imaging and therapy.
Rui Li, Ke Zheng, +11 authors, Mingdong Huang.
Theranostics, 2014 Apr 12; 4(6). PMID: 24723985    Free PMC article.
Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.
Bing Cun Cui, Il Yoon, +2 authors, Young Key Shim.
Int J Mol Sci, 2014 May 13; 15(5). PMID: 24815070    Free PMC article.
Photosensitizing effectiveness of a novel chlorin-based photosensitizer for photodynamic therapy in vitro and in vivo.
Li-Jun Zhang, Jun Bian, +4 authors, Zhi-Long Chen.
J Cancer Res Clin Oncol, 2014 May 28; 140(9). PMID: 24863752
Type 1 phototherapeutic agents, part I: preparation and cancer cell viability studies of novel photolabile sulfenamides.
Amolkumar S Karwa, Amruta R Poreddy, +3 authors, Raghavan Rajagopalan.
ACS Med Chem Lett, 2011 Nov 10; 2(11). PMID: 24900271    Free PMC article.
TSPO 18 kDa (PBR) Targeted Photosensitizers for Cancer Imaging (PET) and PDT.
Yihui Chen, Munawwar Sajjad, +3 authors, Ravindra K Pandey.
ACS Med Chem Lett, 2011 Feb 10; 2(2). PMID: 24900292    Free PMC article.
Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines.
Raghavan Rajagopalan, Tien-Sung Lin, +3 authors, Richard B Dorshow.
ACS Med Chem Lett, 2012 Apr 12; 3(4). PMID: 24900465    Free PMC article.
Synthesis and photophysical studies of self-assembled multicomponent supramolecular coordination prisms bearing porphyrin faces.
Yanhui Shi, Irene Sánchez-Molina, +2 authors, Peter J Stang.
Proc Natl Acad Sci U S A, 2014 Jul 01; 111(26). PMID: 24979805    Free PMC article.
Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.
Artak Tovmasyan, Nelli Babayan, +10 authors, Gennadi Gasparyan.
J Inorg Biochem, 2014 Aug 03; 140. PMID: 25086237    Free PMC article.
A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation.
Jiechao Ge, Minhuan Lan, +12 authors, Xiaodong Han.
Nat Commun, 2014 Aug 12; 5. PMID: 25105845    Free PMC article.
Highly Cited.
Progress of photodynamic therapy applications in the treatment of musculoskeletal sarcoma (Review).
Xianghong Zhang, Tang Liu, Zhihong Li, Xiangsheng Zhang.
Oncol Lett, 2014 Sep 10; 8(4). PMID: 25202342    Free PMC article.
Amplifying the red-emission of upconverting nanoparticles for biocompatible clinically used prodrug-induced photodynamic therapy.
Amol Punjabi, Xiang Wu, +8 authors, Gang Han.
ACS Nano, 2014 Oct 08; 8(10). PMID: 25291544    Free PMC article.
Effects of red laser, infrared, photodynamic therapy, and green LED on the healing process of third-degree burns: clinical and histological study in rats.
Maria Helena Chaves de Vasconcelos Catão, Cassiano Francisco Weege Nonaka, +2 authors, Roniery de Oliveira Costa.
Lasers Med Sci, 2014 Nov 14; 30(1). PMID: 25391372
Thermosensitive liposome formulated indocyanine green for near-infrared triggered photodynamic therapy: in vivo evaluation for triple-negative breast cancer.
Colby S Shemesh, Delaram Moshkelani, Hailing Zhang.
Pharm Res, 2014 Nov 20; 32(5). PMID: 25407543
Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment.
Hongmin Chen, Geoffrey D Wang, +8 authors, Jin Xie.
Nano Lett, 2015 Mar 11; 15(4). PMID: 25756781    Free PMC article.
Synthesis, spectroscopic, and in vitro investigations of 2,6-diiodo-BODIPYs with PDT and bioimaging applications.
Jaime H Gibbs, Zehua Zhou, +3 authors, M Graça H Vicente.
J Photochem Photobiol B, 2015 Mar 17; 145. PMID: 25771382    Free PMC article.
Evaluation of a bacteriochlorin-based photosensitizer's anti-tumor effect in vitro and in vivo.
Li-Jun Zhang, Donal O'Shea, +3 authors, Zhi-Long Chen.
J Cancer Res Clin Oncol, 2015 Mar 26; 141(11). PMID: 25804838
Antitumor activity of photodynamic therapy with a chlorin derivative in vitro and in vivo.
Lai-Xing Wang, Jian-Wei Li, +4 authors, Zhi-Long Chen.
Tumour Biol, 2015 Apr 08; 36(9). PMID: 25846737
Photodynamic therapy mediated by 5-aminolevulinic acid suppresses gliomas growth by decreasing the microvessels.
Wei Yi, Hai-Tao Xu, +8 authors, Qian-Xue Chen.
J Huazhong Univ Sci Technolog Med Sci, 2015 Apr 17; 35(2). PMID: 25877362
Photodynamic therapy in treatment of oral lichen planus.
Diana Mostafa, Bassel Tarakji.
J Clin Med Res, 2015 Apr 18; 7(6). PMID: 25883701    Free PMC article.
A heterogeneous algorithm for PDT dose optimization for prostate.
Martin D Altschuler, Timothy C Zhu, +7 authors, Stephen M Hahn.
Proc SPIE Int Soc Opt Eng, 2009 Feb 18; 7164. PMID: 25914793    Free PMC article.
Immunotherapy for bladder cancer.
Oliver Fuge, Nikhil Vasdev, Paula Allchorne, James Sa Green.
Res Rep Urol, 2015 May 23; 7. PMID: 26000263    Free PMC article.
Reliable Screening of Dye Phototoxicity by Using a Caenorhabditis elegans Fast Bioassay.
Javier Ignacio Bianchi, Juan Carlos Stockert, +3 authors, Sergio Hernán Simonetta.
PLoS One, 2015 Jun 04; 10(6). PMID: 26039060    Free PMC article.
Synthesis, spectroscopic, and cellular properties of α-pegylated cis-A2B2- and A3B-types ZnPcs.
Benson G Ongarora, Zehua Zhou, +3 authors, M Graça H Vicente.
J Porphyr Phthalocyanines, 2015 Jun 13; 18(10-11). PMID: 26064037    Free PMC article.
BODIPY-doped silica nanoparticles with reduced dye leakage and enhanced singlet oxygen generation.
Zhuyuan Wang, Xuehua Hong, +3 authors, Qingdong Zheng.
Sci Rep, 2015 Jul 28; 5. PMID: 26211417    Free PMC article.
Using the Promise of Sonodynamic Therapy in the Clinical Setting against Disseminated Cancers.
Matthew Trendowski.
Chemother Res Pract, 2015 Sep 18; 2015. PMID: 26380110    Free PMC article.
Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages.
Roger R Nani, Alexander P Gorka, +2 authors, Martin J Schnermann.
Angew Chem Int Ed Engl, 2015 Sep 26; 54(46). PMID: 26403799    Free PMC article.
Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer.
Shaojuan Zhang, Ling Yang, +4 authors, Mingfeng Bai.
Acta Biomater, 2015 Oct 04; 28. PMID: 26432436    Free PMC article.
Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study.
Annaji Sreedhar, Indranil Sarkar, +4 authors, Radhikka Barmappa.
J Nat Sci Biol Med, 2015 Nov 26; 6(Suppl 1). PMID: 26604595    Free PMC article.
Photosensitizer and peptide-conjugated PAMAM dendrimer for targeted in vivo photodynamic therapy.
Amreddy Narsireddy, Kurra Vijayashree, +2 authors, Nalam M Rao.
Int J Nanomedicine, 2015 Nov 26; 10. PMID: 26604753    Free PMC article.
Syntheses and cellular investigations of di-aspartate and aspartate-lysine chlorin e(6) conjugates.
R G Waruna Jinadasa, Zehua Zhou, M Graça H Vicente, Kevin M Smith.
Org Biomol Chem, 2015 Dec 04; 14(3). PMID: 26633562    Free PMC article.
Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes.
Alina Y Rwei, Jung-Jae Lee, +5 authors, Daniel S Kohane.
Proc Natl Acad Sci U S A, 2015 Dec 09; 112(51). PMID: 26644576    Free PMC article.
Photoresponsive nanoparticles for drug delivery.
Alina Y Rwei, Weiping Wang, Daniel S Kohane.
Nano Today, 2015 Dec 09; 10(4). PMID: 26644797    Free PMC article.
Synthesis and antitumor activity evaluation of a novel porphyrin derivative for photodynamic therapy in vitro and in vivo.
Li-Jun Zhang, Yi-Jia Yan, +3 authors, Zhi-Long Chen.
Tumour Biol, 2015 Dec 15; 37(5). PMID: 26662801
Assessing of integration of ionizing radiation with Radachlorin-PDT on MCF-7 breast cancer cell treatment.
R Ghoodarzi, V Changizi, A R Montazerabadi, N Eyvazzadaeh.
Lasers Med Sci, 2015 Dec 23; 31(2). PMID: 26690358
A specific photoimmunotheranostics agent to detect and eliminate skin cancer cells expressing EGFR.
Verena von Felbert, Dirk Bauerschlag, +5 authors, Ahmad Fawzi Hussain.
J Cancer Res Clin Oncol, 2016 Feb 06; 142(5). PMID: 26847542
Modeling of Photochemical Reactions in a Focused Laser Beam, II.
Adolfas K Gaigalas, Fern Hunt, Lili Wang.
J Res Natl Inst Stand Technol, 2008 Jan 01; 113(5). PMID: 27096125    Free PMC article.
Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue.
Roarke Horstmeyer, Haowen Ruan, Changhuei Yang.
Nat Photonics, 2015 Jan 01; 9. PMID: 27293480    Free PMC article.
Highly Cited.
Adjunctive effect of antimicrobial photodynamic therapy in induced periodontal disease. Animal study with histomorphometrical, immunohistochemical, and cytokine evaluation.
Paula Gabriela Faciola Pessôa de Oliveira, Adriana Maria Mariano Silveira E Souza, +6 authors, Sérgio Luis Scombatti de Souza.
Lasers Med Sci, 2016 Jun 29; 31(7). PMID: 27351664
P2X7 receptor as a novel drug delivery system to increase the entrance of hydrophilic drugs into cells during photodynamic therapy.
Paulo Anastácio Furtado Pacheco, Leonardo Braga Gomes Ferreira, +5 authors, Luiz Anastacio Alves.
J Bioenerg Biomembr, 2016 Jul 17; 48(4). PMID: 27422545
Photodynamic Therapy in Gynecologic Malignancies: A Review of the Roswell Park Cancer Institute Experience.
Paul C Mayor, Shashikant Lele.
Cancers (Basel), 2016 Sep 27; 8(10). PMID: 27669307    Free PMC article.
Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives.
Yamin Yang, Yue Hu, Hongjun Wang.
Oxid Med Cell Longev, 2016 Sep 28; 2016. PMID: 27672421    Free PMC article.
A next-generation bifunctional photosensitizer with improved water-solubility for photodynamic therapy and diagnosis.
Hirotada Nishie, Hiromi Kataoka, +6 authors, Takashi Joh.
Oncotarget, 2016 Oct 07; 7(45). PMID: 27708235    Free PMC article.
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.
Zijian Zhou, Jibin Song, Liming Nie, Xiaoyuan Chen.
Chem Soc Rev, 2016 Oct 11; 45(23). PMID: 27722328    Free PMC article.
Highly Cited. Review.
Photodynamic therapy of tumors with pyropheophorbide-a-loaded polyethylene glycol-poly(lactic-co-glycolic acid) nanoparticles.
Hui Liu, Mei Zhao, +5 authors, Zhangyong Hong.
Int J Nanomedicine, 2016 Oct 13; 11. PMID: 27729788    Free PMC article.
Recent advances of sonodynamic therapy in cancer treatment.
Guo-Yun Wan, Yang Liu, +3 authors, Ning Zhang.
Cancer Biol Med, 2016 Nov 04; 13(3). PMID: 27807500    Free PMC article.
Assessment of Photodynamic Inactivation against Periodontal Bacteria Mediated by a Chitosan Hydrogel in a 3D Gingival Model.
Po-Chun Peng, Chien-Ming Hsieh, +2 authors, Chin-Tin Chen.
Int J Mol Sci, 2016 Nov 04; 17(11). PMID: 27809278    Free PMC article.
Clinical efficacy of photodynamic therapy.
Ye-Kyu Park, Choong-Hak Park.
Obstet Gynecol Sci, 2016 Nov 30; 59(6). PMID: 27896250    Free PMC article.
On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling.
Michele M Kim, Ashwini A Ghogare, Alexander Greer, Timothy C Zhu.
Phys Med Biol, 2017 Feb 07; 62(5). PMID: 28166056    Free PMC article.
Engineering Remotely Triggered Liposomes to Target Triple Negative Breast Cancer.
Alexandra Sneider, Rahul Jadia, +3 authors, Prakash Rai.
Oncomedicine, 2017 Feb 09; 2. PMID: 28174679    Free PMC article.
Multilayer photodynamic therapy for highly effective and safe cancer treatment.
Ling Yang, Shaojuan Zhang, +3 authors, Mingfeng Bai.
Acta Biomater, 2017 Mar 13; 54. PMID: 28285077    Free PMC article.
Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX.
Christine Cruz-Oliveira, Andreza F Almeida, +7 authors, Andrea T Da Poian.
Antimicrob Agents Chemother, 2017 Mar 30; 61(6). PMID: 28348154    Free PMC article.
In Vivo Activation of Duocarmycin-Antibody Conjugates by Near-Infrared Light.
Roger R Nani, Alexander P Gorka, +4 authors, Martin J Schnermann.
ACS Cent Sci, 2017 May 05; 3(4). PMID: 28470051    Free PMC article.
Lifetime-resolved Photoacoustic (LPA) Spectroscopy for monitoring Oxygen change and Photodynamic Therapy (PDT).
Janggun Jo, Chang Heon Lee, Raoul Kopelman, Xueding Wang.
Proc SPIE Int Soc Opt Eng, 2016 Feb 13; 9708. PMID: 28529402    Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Emerging applications of porphyrins in photomedicine.
Haoyuan Huang, Wentao Song, James Rieffel, Jonathan F Lovell.
Front Phys, 2015 Apr 01; 3. PMID: 28553633    Free PMC article.
High Aspect Ratio Nanotubes Formed by Tobacco Mosaic Virus for Delivery of Photodynamic Agents Targeting Melanoma.
Karin L Lee, Bradley L Carpenter, +2 authors, Nicole F Steinmetz.
ACS Biomater Sci Eng, 2016 May 09; 2(5). PMID: 28713855    Free PMC article.
Review of the progress toward achieving heat confinement-the holy grail of photothermal therapy.
Wangzhong Sheng, Sha He, William J Seare, Adah Almutairi.
J Biomed Opt, 2017 Aug 05; 22(8). PMID: 28776627    Free PMC article.
A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity.
Xingshu Li, Bi-Yuan Zheng, +3 authors, Juyoung Yoon.
Theranostics, 2017 Aug 19; 7(10). PMID: 28819460    Free PMC article.
Ternary cocktail nanoparticles for sequential chemo-photodynamic therapy.
Li Fan, Saisai Zhao, +3 authors, Hong Wu.
J Exp Clin Cancer Res, 2017 Sep 07; 36(1). PMID: 28874173    Free PMC article.
A charge-reversible nanocarrier using PEG-PLL (-g-Ce6, DMA)-PLA for photodynamic therapy.
Chaemin Lim, Taehoon Sim, +4 authors, Kyung Taek Oh.
Int J Nanomedicine, 2017 Sep 09; 12. PMID: 28883728    Free PMC article.
Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice.
Jill A Gadzinski, Jianxia Guo, +5 authors, Julie L Eiseman.
Adv Biol Chem, 2017 Sep 12; 6(6). PMID: 28890844    Free PMC article.
Spatiotemporal Control of Doxorubicin Delivery from "Stealth-Like" Prodrug Micelles.
Li Kong, Dimitrios Poulcharidis, +2 authors, Alexander Kros.
Int J Mol Sci, 2017 Sep 25; 18(10). PMID: 28937592    Free PMC article.
Focusing light through scattering media by transmission matrix inversion.
Jian Xu, Haowen Ruan, +2 authors, Changhuei Yang.
Opt Express, 2017 Nov 03; 25(22). PMID: 29092201    Free PMC article.
PDT dose dosimetry for Photofrin-mediated pleural photodynamic therapy (pPDT).
Yi Hong Ong, Michele M Kim, +5 authors, Timothy C Zhu.
Phys Med Biol, 2017 Nov 07; 63(1). PMID: 29106380    Free PMC article.
Sonophotodynamic therapy mediated by liposomal zinc phthalocyanine in a colon carcinoma tumor model: Role of irradiating arrangement.
Maryam Bakhshizadeh, Toktam Moshirian, +3 authors, Ameneh Sazgarnia.
Iran J Basic Med Sci, 2017 Nov 18; 20(10). PMID: 29147483    Free PMC article.
Applications of functionalized nanomaterials in photodynamic therapy.
Olayemi J Fakayode, Ncediwe Tsolekile, Sandile P Songca, Oluwatobi S Oluwafemi.
Biophys Rev, 2018 Jan 03; 10(1). PMID: 29294258    Free PMC article.
Combination of Ru(ii) complexes and light: new frontiers in cancer therapy.
Cristina Mari, Vanessa Pierroz, Stefano Ferrari, Gilles Gasser.
Chem Sci, 2015 May 01; 6(5). PMID: 29308166    Free PMC article.
Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity.
Reza Yarani, Takehiko Shiraishi, Peter E Nielsen.
Sci Rep, 2018 Jan 14; 8(1). PMID: 29330463    Free PMC article.
Synthesis and Evaluation of a Tetra[6,7]quinoxalinoporphyrazine-based Near Infrared Photosensitizer.
Pin Shao, Shaojuan Zhang, +3 authors, Mingfeng Bai.
RSC Adv, 2018 Feb 20; 7(80). PMID: 29456839    Free PMC article.
Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa.
Kentaro Sueoka, Taiichiro Chikama, +4 authors, Akira Obana.
Lasers Med Sci, 2018 Mar 29; 33(7). PMID: 29589177
New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates.
Xingshu Li, Xiao-Hui Peng, +5 authors, Jian-Dong Huang.
Chem Sci, 2018 Apr 21; 9(8). PMID: 29675251    Free PMC article.
Effect of photodynamic therapy combined with Celecoxib on expression of cyclooxygenase-2 protein in HeLa cells.
Yuanfu Mao, Lishuang Wang, Chen Xu, Shiyu Han.
Oncol Lett, 2018 May 08; 15(5). PMID: 29731857    Free PMC article.
Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators.
Luiz Anastacio Alves, Leonardo Braga Ferreira, +3 authors, Robson Xavier Faria.
Oncotarget, 2018 Jun 05; 9(38). PMID: 29861876    Free PMC article.
Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy.
Lesan Yan, Ahmad Amirshaghaghi, +5 authors, Andrew Tsourkas.
Adv Funct Mater, 2018 Jun 19; 28(16). PMID: 29910700    Free PMC article.
Recent advances in nanoparticle carriers for photodynamic therapy.
Gawon Yi, Suk Ho Hong, +4 authors, Heebeom Koo.
Quant Imaging Med Surg, 2018 Jun 22; 8(4). PMID: 29928608    Free PMC article.
Pollen-Structured Gold Nanoclusters for X-ray Induced Photodynamic Therapy.
Lih Shin Tew, Meng-Ting Cai, +2 authors, Nai-Tzu Chen.
Materials (Basel), 2018 Jul 11; 11(7). PMID: 29987236    Free PMC article.
Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy.
Jingyao Sun, Semen Kormakov, +3 authors, Zhaogang Yang.
Molecules, 2018 Jul 14; 23(7). PMID: 30002333    Free PMC article.
Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70.
Fan Zhang, Yanjie Zhu, Guoxin Fan, Shuo Hu.
Oncol Lett, 2018 Sep 27; 16(4). PMID: 30250570    Free PMC article.
Assessing Configurational Sampling in the Quantum Mechanics/Molecular Mechanics Calculation of Temoporfin Absorption Spectrum and Triplet Density of States.
Martina De Vetta, Omar Baig, +2 authors, Leticia González.
Molecules, 2018 Nov 15; 23(11). PMID: 30424014    Free PMC article.
Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics.
Arianna Gazzi, Laura Fusco, +5 authors, Lucia Gemma Delogu.
Front Bioeng Biotechnol, 2019 Nov 12; 7. PMID: 31709252    Free PMC article.
Red Blood Cell-Facilitated Photodynamic Therapy for Cancer Treatment.
Wei Tang, Zipeng Zhen, +10 authors, Jin Xie.
Adv Funct Mater, 2016 Mar 15; 26(11). PMID: 31749670    Free PMC article.
Development of Prodrugs for PDT-Based Combination Therapy Using a Singlet-Oxygen-Sensitive Linker and Quantitative Systems Pharmacology.
Luong Nguyen, Mengjie Li, Sukyung Woo, Youngjae You.
J Clin Med, 2019 Dec 19; 8(12). PMID: 31847080    Free PMC article.
Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy.
Jaspreet Singh Nagi, Kenneth Skorenko, +2 authors, Amber L Doiron.
Materials (Basel), 2019 Dec 22; 13(1). PMID: 31861462    Free PMC article.
Nanoparticles to mediate X-ray-induced photodynamic therapy and Cherenkov radiation photodynamic therapy.
Benjamin Cline, Ian Delahunty, Jin Xie.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2018 Aug 01; 11(2). PMID: 30063116    Free PMC article.
Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice.
Karl W Beeson, Evgueni Parilov, +2 authors, Timothy C Zhu.
J Biomed Opt, 2019 Mar 16; 24(3). PMID: 30873764    Free PMC article.
Molecular Tools to Generate Reactive Oxygen Species in Biological Systems.
Ying Xiong, Xiaodong Tian, Hui-Wang Ai.
Bioconjug Chem, 2019 Apr 16; 30(5). PMID: 30986044    Free PMC article.
Green synthesis of silver nanoparticles via Cynara scolymus leaf extracts: The characterization, anticancer potential with photodynamic therapy in MCF7 cells.
Omer Erdogan, Muruvvet Abbak, +4 authors, Ozge Cevik.
PLoS One, 2019 Jun 21; 14(6). PMID: 31220110    Free PMC article.
Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy.
Yuan Liu, Christina S Gong, +13 authors, Xiaoyuan Chen.
Theranostics, 2019 Jun 28; 9(10). PMID: 31244923    Free PMC article.
Photodynamic therapy combined with a cysteine proteinase inhibitor synergistically decrease VEGF production and promote tumour necrosis in a rat mammary carcinoma.
B Zsebik, K Symonowicz, +3 authors, G Vereb.
Cell Prolif, 2007 Jan 18; 40(1). PMID: 17227294    Free PMC article.
Mutual impact of clinically translatable near-infrared dyes on photoacoustic image contrast and in vitro photodynamic therapy efficacy.
Ljubica Z Petrovic, Marvin Xavierselvan, +5 authors, Srivalleesha Mallidi.
J Biomed Opt, 2020 Mar 01; 25(6). PMID: 32112541    Free PMC article.
Multifunctional phototheranostic nanomedicine for cancer imaging and treatment.
D Gao, X Guo, +7 authors, Z Yang.
Mater Today Bio, 2020 Mar 27; 5. PMID: 32211603    Free PMC article.
A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids.
Ahtasham Raza, Stuart A Archer, +5 authors, John W Haycock.
J Am Chem Soc, 2020 Feb 18; 142(10). PMID: 32065521    Free PMC article.
Recent advances in photodynamic therapy for cancer and infectious diseases.
Xutong Shi, Can Yang Zhang, Jin Gao, Zhenjia Wang.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2019 May 07; 11(5). PMID: 31058443    Free PMC article.
The Self-Assembly of a Cyclometalated Palladium Photosensitizer into Protein-Stabilized Nanorods Triggers Drug Uptake In Vitro and In Vivo.
Xue-Quan Zhou, Ming Xiao, +7 authors, Sylvestre Bonnet.
J Am Chem Soc, 2020 May 08; 142(23). PMID: 32378894    Free PMC article.
The Influence of Hypericin-Mediated Photodynamic Therapy on Interleukin-8 and -10 Secretion in Colon Cancer Cells.
Marta Kaleta-Richter, David Aebisher, +3 authors, Aleksandra Kawczyk-Krupka.
Integr Cancer Ther, 2020 Jun 09; 19. PMID: 32508149    Free PMC article.
Utility of Photodynamic Therapy in Dentistry: Current Concepts.
Anette Stájer, Szilvia Kajári, +2 authors, Zoltán Baráth.
Dent J (Basel), 2020 May 13; 8(2). PMID: 32392793    Free PMC article.
Reactive oxygen species explicit dosimetry to predict local tumor growth for Photofrin-mediated photodynamic therapy.
Tianqi Sheng, Yihong Ong, Theresa M Busch, Timothy C Zhu.
Biomed Opt Express, 2020 Sep 15; 11(8). PMID: 32923066    Free PMC article.
Applications of SNAP-tag technology in skin cancer therapy.
Eden Rebecca Padayachee, Henry Ademola Adeola, +4 authors, Stefan Barth.
Health Sci Rep, 2019 Feb 28; 2(2). PMID: 30809593    Free PMC article.
Preparation and evaluation of 99mTc-labeled porphyrin complexes prepared using PNP and HYNIC cores: studying the effects of core selection on pharmacokinetics and tumor uptake in a mouse model.
Mohini Guleria, Tapas Das, +4 authors, Ashutosh Dash.
Medchemcomm, 2019 May 07; 10(4). PMID: 31057740    Free PMC article.
Bioorthogonal Turn-On BODIPY-Peptide Photosensitizers for Tailored Photodynamic Therapy.
Greta Linden, Olalla Vázquez.
Chemistry, 2020 Jul 09; 26(44). PMID: 32638402    Free PMC article.
Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma.
Fleury Augustin Nsole Biteghe, Nyangone Ekome Toung Chalomie, +7 authors, Stefan Barth.
Biomedicines, 2020 Sep 10; 8(9). PMID: 32899183    Free PMC article.
Daylight Photodynamic Therapy: An Update.
Chaw-Ning Lee, Rosie Hsu, Hsuan Chen, Tak-Wah Wong.
Molecules, 2020 Nov 12; 25(21). PMID: 33171665    Free PMC article.
Recent Advances in Self-Exciting Photodynamic Therapy.
Nicholas Thomas Blum, Yifan Zhang, +2 authors, Peng Huang.
Front Bioeng Biotechnol, 2020 Nov 17; 8. PMID: 33195164    Free PMC article.
Synthesis and in vitro PDT evaluation of new porphyrins containing meso-epoxymethylaryl cationic groups.
Jaqueline Carneiro, Alan Gonçalves, +3 authors, Maria da Graça Henriques Vicente.
Lasers Surg Med, 2018 Apr 25; 50(5). PMID: 29691890    Free PMC article.
Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi.
Kentaro Sueoka, Taiichiro Chikama, +4 authors, Akira Obana.
Lasers Med Sci, 2018 Oct 05; 34(4). PMID: 30284654
Effects of nanoparticles of hydroxy-aluminum phthalocyanine on markers of liver injury and glucose metabolism in diabetic mice.
M A B Melo, W Caetano, +4 authors, V A F Godoi.
Braz J Med Biol Res, 2018 Dec 06; 52(1). PMID: 30517288    Free PMC article.
A H₂O₂-Responsive Boron Dipyrromethene-Based Photosensitizer for Imaging-Guided Photodynamic Therapy.
Zhi-Wei Wang, Dan Su, +3 authors, Jian-Yong Liu.
Molecules, 2018 Dec 24; 24(1). PMID: 30577688    Free PMC article.
Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring.
Conor C Horgan, Mads S Bergholt, +6 authors, Molly M Stevens.
Theranostics, 2021 Jan 08; 11(4). PMID: 33408795    Free PMC article.
Review of in vivo optical molecular imaging and sensing from x-ray excitation.
Brian W Pogue, Rongxiao Zhang, +4 authors, Sergei A Vinogradov.
J Biomed Opt, 2021 Jan 03; 26(1). PMID: 33386709    Free PMC article.
Photocontrolled activation of small molecule cancer therapeutics.
M Michael Dcona, Koushambi Mitra, Matthew C T Hartman.
RSC Med Chem, 2021 Jan 23; 11(9). PMID: 33479692    Free PMC article.
Photodynamic Priming Modulates Endothelial Cell-Cell Junction Phenotype for Light-activated Remote Control of Drug Delivery.
Collin T Inglut, Kelsey M Gray, +5 authors, Huang-Chiao Huang.
IEEE J Sel Top Quantum Electron, 2021 Feb 02; 27(4). PMID: 33519171    Free PMC article.
Biogenic Gold Nanoparticles Decrease Methylene Blue Photobleaching and Enhance Antimicrobial Photodynamic Therapy.
Irena Maliszewska, Ewelina Wanarska, +2 authors, Katarzyna Matczyszyn.
Molecules, 2021 Jan 29; 26(3). PMID: 33504099    Free PMC article.
Clinical development and potential of photothermal and photodynamic therapies for cancer.
Xingshu Li, Jonathan F Lovell, Juyoung Yoon, Xiaoyuan Chen.
Nat Rev Clin Oncol, 2020 Jul 24; 17(11). PMID: 32699309
Recent advances in liposome formulations for breast cancer therapeutics.
Biyao Yang, Bo-Ping Song, +2 authors, Wei Deng.
Cell Mol Life Sci, 2021 May 12; 78(13). PMID: 33974093
Balanced Intersystem Crossing in Iodinated Silicon-Fluoresceins Allows New Class of Red Shifted Theranostic Agents.
Sultan Cetin, Zubeyir Elmazoglu, +3 authors, Safacan Kolemen.
ACS Med Chem Lett, 2021 Jun 01; 12(5). PMID: 34055222    Free PMC article.
The Role of Triplet States in the Photodissociation of a Platinum Azide Complex by a Density Matrix Renormalization Group Method.
Leon Freitag, Leticia González.
J Phys Chem Lett, 2021 May 20; 12(20). PMID: 34006109    Free PMC article.
Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy.
Mohammad Tavakkoli Yaraki, Min Wu, +4 authors, Yen Nee Tan.
Nanomicro Lett, 2021 Jun 18; 13(1). PMID: 34138261    Free PMC article.
Photodynamic Therapy-Current Limitations and Novel Approaches.
Gurcan Gunaydin, M Emre Gedik, Seylan Ayan.
Front Chem, 2021 Jun 29; 9. PMID: 34178948    Free PMC article.
Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer.
Ruth Prieto-Montero, Alejandro Prieto-Castañeda, +4 authors, Virginia Martínez-Martínez.
Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34205599    Free PMC article.
Targeted Cancer Therapy Using Compounds Activated by Light.
Petra Dunkel, Janez Ilaš.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34209493    Free PMC article.
Photodynamic Therapy for the Treatment and Diagnosis of Cancer-A Review of the Current Clinical Status.
Gurcan Gunaydin, M Emre Gedik, Seylan Ayan.
Front Chem, 2021 Aug 20; 9. PMID: 34409014    Free PMC article.
Radiodynamic therapy using 15-MV radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo.
Joseph V Panetta, Dusica Cvetkovic, +2 authors, C-M Charlie Ma.
Phys Med Biol, 2020 May 29; 65(16). PMID: 32464613    Free PMC article.
Could Photodynamic Therapy Be a Promising Therapeutic Modality in Hepatocellular Carcinoma Patients? A Critical Review of Experimental and Clinical Studies.
Abhishek Kumar, Olivier Moralès, +2 authors, Emmanuel Boleslawski.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680325    Free PMC article.
Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer.
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher.
Pharmaceutics, 2021 Oct 24; 13(10). PMID: 34683855    Free PMC article.
Progress of Phototherapy Applications in the Treatment of Bone Cancer.
Jiachen Sun, Fei Xing, +4 authors, Ulrike Ritz.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34768789    Free PMC article.
Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy.
Wei Liu, Xingqun Ma, +5 authors, Shouju Wang.
Molecules, 2021 Dec 11; 26(23). PMID: 34885922    Free PMC article.
Near-infrared mediated orthogonal bioimaging and intracellular tracking of upconversion nanophotosensitizers.
Yi Xiang, Shanshan Zheng, +3 authors, Xiaohui Zhu.
Mikrochim Acta, 2022 Feb 25; 189(3). PMID: 35201432
An Engineered Nanocomplex with Photodynamic and Photothermal Synergistic Properties for Cancer Treatment.
Eli Varon, Gaddi Blumrosen, +8 authors, Orit Shefi.
Int J Mol Sci, 2022 Feb 27; 23(4). PMID: 35216400    Free PMC article.
The Immunogenetic Aspects of Photodynamic Therapy.
Chaw-Ning Lee, Tak-Wah Wong.
Adv Exp Med Biol, 2022 Mar 15; 1367. PMID: 35286707
Photodynamic Therapeutic Effect of Nanostructured Metal Sulfide Photosensitizers on Cancer Treatment.
Daysi Diaz-Diestra, Hanna Madadi Gholipour, +2 authors, Juan Beltran-Huarac.
Nanoscale Res Lett, 2022 Mar 09; 17(1). PMID: 35258742    Free PMC article.
N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposites: A Study of ROS-Forming Mechanisms, Cytotoxicity and Photodynamic Therapy.
Pravena Ramachandran, Boon-Keat Khor, +4 authors, Hooi Ling Lee.
Biomedicines, 2022 Feb 26; 10(2). PMID: 35203630    Free PMC article.
Recent Approaches to the Identification of Novel Microtubule-Targeting Agents.
Susanna Eli, Rossella Castagna, Marina Mapelli, Emilio Parisini.
Front Mol Biosci, 2022 Apr 16; 9. PMID: 35425809    Free PMC article.
Mechanochemical generation of singlet oxygen.
Abdurrahman Turksoy, Deniz Yildiz, +4 authors, Engin U Akkaya.
RSC Adv, 2020 Mar 02; 10(16). PMID: 35497229    Free PMC article.
Application of Monolayer Cell Cultures for Investigating Basic Mechanisms of Photodynamic Therapy.
Mans Broekgaarden.
Methods Mol Biol, 2022 May 04; 2451. PMID: 35505006
Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy.
Yang Yang, Jinshu Huang, +5 authors, Tao Zhang.
Nat Commun, 2022 Jun 08; 13(1). PMID: 35672303