Journal Article
. 2005 Jun; 174(12):7516-23.
doi: 10.4049/jimmunol.174.12.7516.

Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor

Amit A Lugade 1 James P Moran  Scott A Gerber  Robert C Rose  John G Frelinger  Edith M Lord  
Affiliations
  • PMID: 15944250
  •     403 citations

Abstract

Immunotherapy of cancer is attractive because of its potential for specificity and limited side effects. The efficacy of this approach may be improved by providing adjuvant signals and an inflammatory environment for immune cell activation. We evaluated antitumor immune responses in mice after treatment of OVA-expressing B16-F0 tumors with single (15 Gy) or fractionated (5 x 3 Gy) doses of localized ionizing radiation. Irradiated mice had cells with greater capability to present tumor Ags and specific T cells that secreted IFN-gamma upon peptide stimulation within tumor-draining lymph nodes than nonirradiated mice. Immune activation in tumor-draining lymph nodes correlated with an increase in the number of CD45(+) cells infiltrating single dose irradiated tumors compared with nonirradiated mice. Similarly, irradiated mice had increased numbers of tumor-infiltrating lymphocytes that secreted IFN-gamma and lysed tumor cell targets. Peptide-specific IFN-gamma responses were directed against both the class I and class II MHC-restricted OVA peptides OVA(257-264) and OVA(323-339), respectively, as well as the endogenous class I MHC-restricted B16 tumor peptide tyrosinase-related protein 2(180-188). Adoptive transfer studies indicated that the increased numbers of tumor Ag-specific immune cells within irradiated tumors were most likely due to enhanced trafficking of these cells to the tumor site. Together these results suggest that localized radiation can increase both the generation of antitumor immune effector cells and their trafficking to the tumor site.

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TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy.
Stephen L Shiao, Brian Ruffell, +3 authors, Lisa M Coussens.
Cancer Immunol Res, 2015 Feb 27; 3(5). PMID: 25716473    Free PMC article.
Highly Cited.
TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity.
Claire Vanpouille-Box, Julie M Diamond, +5 authors, Sandra Demaria.
Cancer Res, 2015 Apr 11; 75(11). PMID: 25858148    Free PMC article.
Highly Cited.
Targeted noninvasive imaging of the innate immune response.
Melissa N McCracken, Caius G Radu.
Proc Natl Acad Sci U S A, 2015 May 03; 112(19). PMID: 25934920    Free PMC article.
Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy.
Oana Draghiciu, Joyce Lubbers, Hans W Nijman, Toos Daemen.
Oncoimmunology, 2015 May 08; 4(1). PMID: 25949858    Free PMC article.
Highly Cited. Review.
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.
Oana Draghiciu, Hans W Nijman, +2 authors, Toos Daemen.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949902    Free PMC article.
Stereotactic radiation therapy combined with immunotherapy: augmenting the role of radiation in local and systemic treatment.
Andrew B Sharabi, Phuoc T Tran, +2 authors, Theodore L Deweese.
Oncology (Williston Park), 2015 May 17; 29(5). PMID: 25979541    Free PMC article.
Review.
In-situ tumor vaccination: Bringing the fight to the tumor.
Robert H Pierce, Jean S Campbell, +2 authors, Holbrook E K Kohrt.
Hum Vaccin Immunother, 2015 Jun 10; 11(8). PMID: 26055074    Free PMC article.
Review.
T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it?
Florian Anzengruber, Pinar Avci, Lucas Freitas de Freitas, Michael R Hamblin.
Photochem Photobiol Sci, 2015 Jun 13; 14(8). PMID: 26062987    Free PMC article.
The antitumor immune response generated by fractionated radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade.
S J Dovedi, T M Illidge.
Oncoimmunology, 2015 Jul 04; 4(7). PMID: 26140246    Free PMC article.
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment.
Claire Vanpouille-Box, Karsten A Pilones, +2 authors, Sandra Demaria.
Vaccine, 2015 Jul 08; 33(51). PMID: 26148880    Free PMC article.
Review.
Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment.
J David Peske, Amber B Woods, Victor H Engelhard.
Adv Cancer Res, 2015 Jul 29; 128. PMID: 26216636    Free PMC article.
Review.
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.
J Naidoo, D B Page, +5 authors, J D Wolchok.
Ann Oncol, 2015 Sep 16; 26(12). PMID: 26371282    Free PMC article.
Highly Cited. Review.
IL-1βR-dependent priming of antitumor CD4+ T cells and sustained antitumor immunity after peri-tumoral treatment with MSU and mycobacteria.
Sabine Kuhn, Jianping Yang, +3 authors, Franca Ronchese.
Oncoimmunology, 2015 Oct 10; 4(10). PMID: 26451307    Free PMC article.
Definitive Management of Oligometastatic Melanoma in a Murine Model Using Combined Ablative Radiation Therapy and Viral Immunotherapy.
Miran Blanchard, Kevin G Shim, +12 authors, Richard Vile.
Int J Radiat Oncol Biol Phys, 2015 Oct 16; 93(3). PMID: 26461000    Free PMC article.
Immunomodulatory effects of radiation: what is next for cancer therapy?
Anita Kumari, Samantha S Simon, Tomika D Moody, Charlie Garnett-Benson.
Future Oncol, 2015 Dec 02; 12(2). PMID: 26621553    Free PMC article.
Review.
Monocyte-Derived Dendritic Cells Are Essential for CD8(+) T Cell Activation and Antitumor Responses After Local Immunotherapy.
Sabine Kuhn, Jianping Yang, Franca Ronchese.
Front Immunol, 2015 Dec 05; 6. PMID: 26635798    Free PMC article.
Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.
Matthias Leisegang, Boris Engels, +9 authors, Hans Schreiber.
Clin Cancer Res, 2015 Dec 17; 22(11). PMID: 26667491    Free PMC article.
Radiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery.
Mi-Sook Kim, Wonwoo Kim, +5 authors, Chang W Song.
Radiat Oncol J, 2016 Jan 13; 33(4). PMID: 26756026    Free PMC article.
Review.
A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II).
Shankar Siva, Tomas Kron, +13 authors, David Ball.
BMC Cancer, 2016 Mar 06; 16. PMID: 26944262    Free PMC article.
Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
Michael B Bernstein, Sunil Krishnan, James W Hodge, Joe Y Chang.
Nat Rev Clin Oncol, 2016 Mar 10; 13(8). PMID: 26951040    Free PMC article.
Highly Cited. Review.
Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy.
Simon J Dovedi, Amy L Adlard, +14 authors, Timothy M Illidge.
Oncotarget, 2016 Mar 10; 7(13). PMID: 26959743    Free PMC article.
Radiobiology of hypofractionated stereotactic radiotherapy: what are the optimal fractionation schedules?
Yuta Shibamoto, Akifumi Miyakawa, Shinya Otsuka, Hiromitsu Iwata.
J Radiat Res, 2016 Mar 24; 57 Suppl 1. PMID: 27006380    Free PMC article.
Review.
Feasibility study of DCs/CIKs combined with thoracic radiotherapy for patients with locally advanced or metastatic non-small-cell lung cancer.
Luping Zhang, Yanmei Xu, +5 authors, Jianguo Sun.
Radiat Oncol, 2016 Apr 22; 11. PMID: 27097970    Free PMC article.
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.
Paula Kroon, Jules Gadiot, +7 authors, Inge Verbrugge.
Cancer Immunol Immunother, 2016 May 11; 65(6). PMID: 27160390    Free PMC article.
What does the future hold for immunotherapy in cancer?
Jarushka Naidoo, Bob T Li, Katja Schindler, David B Page.
Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275490    Free PMC article.
Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance.
Wenxin Zheng, Kinga B Skowron, +8 authors, Ralph R Weichselbaum.
Oncotarget, 2016 Jun 28; 7(28). PMID: 27343548    Free PMC article.
Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation.
Lisa Deloch, Anja Derer, +3 authors, Udo S Gaipl.
Front Oncol, 2016 Jul 06; 6. PMID: 27379203    Free PMC article.
Highly Cited. Review.
Integrating conventional and antibody-based targeted anticancer treatment into immunotherapy.
M Michelle Xu, Y Pu, R R Weichselbaum, Y-X Fu.
Oncogene, 2016 Jul 19; 36(5). PMID: 27425593    Free PMC article.
Review.
Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors.
Eric D Brooks, Jonathan E Schoenhals, +4 authors, James W Welsh.
Cancer J, 2016 Jul 22; 22(4). PMID: 27441745    Free PMC article.
Review.
Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy.
Ying-Chieh Yang, Chi-Shiun Chiang.
Front Oncol, 2016 Jul 23; 6. PMID: 27446811    Free PMC article.
Review.
Stereotactic ablative radiotherapy and immunotherapy combinations: turning the future into systemic therapy?
Richard C Walshaw, Jamie Honeychurch, Tim M Illidge.
Br J Radiol, 2016 Aug 25; 89(1066). PMID: 27556933    Free PMC article.
Review.
Reevaluating stereotactic radiosurgery for glioblastoma: new potential for targeted dose-escalation.
Ted K Yanagihara, Heva J Saadatmand, Tony J C Wang.
J Neurooncol, 2016 Sep 16; 130(3). PMID: 27632018
Review.
Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF.
Tsuguhide Takeshima, Laurentiu M Pop, +3 authors, Raquibul Hannan.
Proc Natl Acad Sci U S A, 2016 Sep 22; 113(40). PMID: 27651484    Free PMC article.
Current clinical trials testing the combination of immunotherapy with radiotherapy.
Josephine Kang, Sandra Demaria, Silvia Formenti.
J Immunother Cancer, 2016 Sep 24; 4. PMID: 27660705    Free PMC article.
Highly Cited.
Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer.
Grit S Herter-Sprie, Shohei Koyama, +18 authors, Kwok-Kin Wong.
JCI Insight, 2016 Oct 05; 1(9). PMID: 27699275    Free PMC article.
Radiation-induced immune responses: mechanisms and therapeutic perspectives.
Hoibin Jeong, Seoyeon Bok, +2 authors, G-One Ahn.
Blood Res, 2016 Oct 11; 51(3). PMID: 27722125    Free PMC article.
Review.
Radiotherapy: Changing the Game in Immunotherapy.
Sandra Demaria, C Norman Coleman, Silvia C Formenti.
Trends Cancer, 2016 Oct 25; 2(6). PMID: 27774519    Free PMC article.
Highly Cited. Review.
Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy.
Maarten Swart, Inge Verbrugge, Joost B Beltman.
Front Oncol, 2016 Nov 17; 6. PMID: 27847783    Free PMC article.
Highly Cited. Review.
Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes.
Kelli A Connolly, Brian A Belt, +6 authors, Scott A Gerber.
Oncotarget, 2016 Nov 17; 7(52). PMID: 27852031    Free PMC article.
Synergistic locoregional chemoradiotherapy using a composite liposome-in-gel system as an injectable drug depot.
Shruti GuhaSarkar, Kamal Pathak, +4 authors, Rinti Banerjee.
Int J Nanomedicine, 2016 Dec 13; 11. PMID: 27942215    Free PMC article.
The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications.
Michael Spiotto, Yang-Xin Fu, Ralph R Weichselbaum.
Sci Immunol, 2016 Dec 27; 1(3). PMID: 28018989    Free PMC article.
Radiotherapy and immune checkpoint blockades: a snapshot in 2016.
Taeryool Koo, In Ah Kim.
Radiat Oncol J, 2016 Dec 30; 34(4). PMID: 28030901    Free PMC article.
Review.
Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells.
Anja Derer, Martina Spiljar, +4 authors, Udo S Gaipl.
Front Immunol, 2017 Jan 10; 7. PMID: 28066420    Free PMC article.
Highly Cited.
Stereotactic body radiotherapy in the era of radiotherapy with immunotherapy.
Xiaolin Ge, Hongcheng Zhu, Wangshu Dai, Xinchen Sun.
J Thorac Dis, 2017 Jan 10; 8(11). PMID: 28066559    Free PMC article.
Pneumonitis in cancer patients receiving anti-PD-1 and radiotherapies: Three case reports.
Chieh-Sheng Lu, Jin-Hwang Liu.
Medicine (Baltimore), 2017 Jan 11; 96(1). PMID: 28072716    Free PMC article.
Radiotherapy and immunotherapy: a beneficial liaison?
Ralph R Weichselbaum, Hua Liang, Liufu Deng, Yang-Xin Fu.
Nat Rev Clin Oncol, 2017 Jan 18; 14(6). PMID: 28094262
Highly Cited. Review.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone.
Siwen Hu-Lieskovan, Antoni Ribas.
Cancer J, 2017 Jan 24; 23(1). PMID: 28114250    Free PMC article.
Review.
Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen.
Gilda G Hillman, Lyndsey A Reich, +7 authors, Philippe Slos.
J Immunother Cancer, 2017 Jan 25; 5. PMID: 28116088    Free PMC article.
Immune Modulation by Androgen Deprivation and Radiation Therapy: Implications for Prostate Cancer Immunotherapy.
Jennifer L Kalina, David S Neilson, +4 authors, Julian J Lum.
Cancers (Basel), 2017 Jan 31; 9(2). PMID: 28134800    Free PMC article.
Review.
Noninvasive monitoring of cancer therapy induced activated T cells using [18F]FB-IL-2 PET imaging.
S V Hartimath, O Draghiciu, +5 authors, E F J de Vries.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197364    Free PMC article.
Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response.
Monika Savarin, Urska Kamensek, +2 authors, Gregor Sersa.
Radiol Oncol, 2017 Mar 08; 51(1). PMID: 28265230    Free PMC article.
The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
Zishuo I Hu, Heather L McArthur, Alice Y Ho.
Curr Breast Cancer Rep, 2017 Mar 28; 9(1). PMID: 28344743    Free PMC article.
Highly Cited. Review.
Response to the treatment immediately before nivolumab monotherapy may predict clinical response to nivolumab in patients with non-small cell lung cancer.
Haruki Kobayashi, Shota Omori, +7 authors, Toshiaki Takahashi.
Int J Clin Oncol, 2017 Apr 07; 22(4). PMID: 28382561
A Century of Radiation Therapy and Adaptive Immunity.
Dörthe Schaue.
Front Immunol, 2017 Apr 27; 8. PMID: 28443099    Free PMC article.
Review.
Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases.
Kamran A Ahmed, Sungjune Kim, +12 authors, Bradford A Perez.
J Neurooncol, 2017 May 04; 133(2). PMID: 28466250
Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer.
Heath D Skinner, Uma Giri, +15 authors, John V Heymach.
Clin Cancer Res, 2017 May 10; 23(11). PMID: 28476872    Free PMC article.
Spine Stereotactic Body Radiotherapy: Indications, Outcomes, and Points of Caution.
Chia-Lin Tseng, Wietse Eppinga, +10 authors, Arjun Sahgal.
Global Spine J, 2017 May 17; 7(2). PMID: 28507888    Free PMC article.
Harnessing the potential synergy of combining radiation therapy and immunotherapy for thoracic malignancies.
Charles B Simone, Abigail T Berman, Salma K Jabbour.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529893    Free PMC article.
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer.
Salma K Jabbour, Abigail T Berman, Charles B Simone.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529894    Free PMC article.
Review.
Preclinical rationale for combining radiation therapy and immunotherapy beyond checkpoint inhibitors (i.e., CART).
James P Flynn, Mark H O'Hara, Saumil J Gandhi.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529898    Free PMC article.
Review.
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors.
Suchit H Patel, Andreas Rimner, Roger B Cohen.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529901    Free PMC article.
Review.
Immunotherapy and radiation therapy for malignant pleural mesothelioma.
Evan W Alley, Sharyn I Katz, Keith A Cengel, Charles B Simone.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529903    Free PMC article.
Review.
Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer.
Allison M Campbell, Roy H Decker.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529904    Free PMC article.
Review.
Delivering safer immunotherapies for cancer.
Lauren Milling, Yuan Zhang, Darrell J Irvine.
Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888    Free PMC article.
Highly Cited. Review.
Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial.
Narek Shaverdian, Aaron E Lisberg, +5 authors, Percy Lee.
Lancet Oncol, 2017 May 30; 18(7). PMID: 28551359    Free PMC article.
Highly Cited.
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
Claire Vanpouille-Box, Amandine Alard, +7 authors, Sandra Demaria.
Nat Commun, 2017 Jun 10; 8. PMID: 28598415    Free PMC article.
Highly Cited.
Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies.
Jeong A Park, Nai-Kong V Cheung.
Cancer Treat Rev, 2017 Jun 18; 58. PMID: 28622628    Free PMC article.
Review.
A Pilot Study of Stereotactic Body Radiation Therapy Combined with Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma.
Anurag K Singh, Timothy B Winslow, +13 authors, Jason B Muhitch.
Clin Cancer Res, 2017 Jun 21; 23(17). PMID: 28630212    Free PMC article.
Radiotherapy for renal cell carcinoma: renaissance of an overlooked approach.
Shankar Siva, Gargi Kothari, +4 authors, Simon S Lo.
Nat Rev Urol, 2017 Jun 21; 14(9). PMID: 28631740
Review.
Neoadjuvant radiotherapy of early-stage breast cancer and long-term disease-free survival.
Jan Poleszczuk, Kimberly Luddy, +5 authors, Heiko Enderling.
Breast Cancer Res, 2017 Jul 02; 19(1). PMID: 28666457    Free PMC article.
Dose-dependent enhancement of T-lymphocyte priming and CTL lysis following ionizing radiation in an engineered model of oral cancer.
Megan Morisada, Ellen C Moore, +5 authors, Clint T Allen.
Oral Oncol, 2017 Jul 10; 71. PMID: 28688697    Free PMC article.
A perspective on the impact of radiation therapy on the immune rheostat.
William H McBride, Ekambaram Ganapathy, +3 authors, Dörthe Schaue.
Br J Radiol, 2017 Jul 15; 90(1078). PMID: 28707537    Free PMC article.
Review.
Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers.
Claire Vanpouille-Box, Silvia C Formenti, Sandra Demaria.
Clin Cancer Res, 2017 Jul 29; 24(2). PMID: 28751442    Free PMC article.
Highly Cited. Review.
Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection.
Carsten Herskind, Frederik Wenz, Frank A Giordano.
Front Oncol, 2017 Aug 10; 7. PMID: 28791250    Free PMC article.
Review.
Combining Oncolytic Adenovirus with Radiation-A Paradigm for the Future of Radiosensitization.
Sean M O'Cathail, Tzveta D Pokrovska, +3 authors, Maria A Hawkins.
Front Oncol, 2017 Aug 10; 7. PMID: 28791251    Free PMC article.
Review.
Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer.
Verónica A Trivillin, Emiliano C C Pozzi, +9 authors, Amanda E Schwint.
Radiat Environ Biophys, 2017 Aug 10; 56(4). PMID: 28791476
Optimizing tumor immune response through combination of radiation and immunotherapy.
Alissar El Chediak, Ali Shamseddine, +3 authors, Youssef H Zeidan.
Med Oncol, 2017 Aug 23; 34(9). PMID: 28828581
Review.
Emerging Therapies for Stage III Non-Small Cell Lung Cancer: Stereotactic Body Radiation Therapy and Immunotherapy.
Sameera S Kumar, Kristin A Higgins, Ronald C McGarry.
Front Oncol, 2017 Sep 21; 7. PMID: 28929083    Free PMC article.
Review.
Preoperative short- vs. long-course chemoradiotherapy with delayed surgery for locally advanced rectal cancer.
Mi Joo Chung, Dong Wook Kim, +4 authors, Choon Sik Jeong.
Oncotarget, 2016 Jun 24; 8(36). PMID: 28947986    Free PMC article.
Improving radiotherapy in cancer treatment: Promises and challenges.
Helen H W Chen, Macus Tien Kuo.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977985    Free PMC article.
Review.
Immune recognition of irradiated cancer cells.
Erik Wennerberg, Claire Vanpouille-Box, +3 authors, Lorenzo Galluzzi.
Immunol Rev, 2017 Oct 14; 280(1). PMID: 29027232    Free PMC article.
Review.
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.
Ayman Oweida, Shelby Lennon, +11 authors, Sana D Karam.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123967    Free PMC article.
Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells.
Nils-Petter Rudqvist, Karsten A Pilones, +7 authors, Sandra Demaria.
Cancer Immunol Res, 2017 Nov 29; 6(2). PMID: 29180535    Free PMC article.
Comprehensive assessment of circulating immune cell populations in response to stereotactic body radiation therapy in patients with liver cancer.
Michael P Gustafson, Svetlana Bornschlegl, +4 authors, Christopher L Hallemeier.
Adv Radiat Oncol, 2017 Dec 06; 2(4). PMID: 29204520    Free PMC article.
Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis.
Jean-Pierre Pouget, Alexandros G Georgakilas, Jean-Luc Ravanat.
Antioxid Redox Signal, 2018 Jan 20; 29(15). PMID: 29350049    Free PMC article.
Review.
AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity.
Dan Liang, Lin Tian, +14 authors, William K Decker.
Front Immunol, 2018 Jan 31; 8. PMID: 29379495    Free PMC article.
Radiation effects on antitumor immune responses: current perspectives and challenges.
Thomas Walle, Rafael Martinez Monge, +3 authors, Fernando Lecanda.
Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383033    Free PMC article.
Highly Cited. Review.
Radiation and Anti-Cancer Vaccines: A Winning Combination.
Alexandra Cadena, Taylor R Cushman, +3 authors, Maria Angelica Cortez.
Vaccines (Basel), 2018 Feb 02; 6(1). PMID: 29385680    Free PMC article.
Review.
Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Jason J Luke, Jeffrey M Lemons, +17 authors, Steven J Chmura.
J Clin Oncol, 2018 Feb 14; 36(16). PMID: 29437535    Free PMC article.
Highly Cited.
Exploring the rationale for combining ionizing radiation and immune checkpoint blockade in head and neck cancer.
Megan Morisada, Michael Chamberlin, Clint Allen.
Head Neck, 2018 Feb 21; 40(6). PMID: 29461655    Free PMC article.
Review.
PACIFIC trial: new perspectives for immunotherapy in lung cancer.
Francesco Agustoni, Fred R Hirsch.
Transl Lung Cancer Res, 2018 Mar 14; 7(Suppl 1). PMID: 29531898    Free PMC article.
Comparative analysis of the effect of different radiotherapy regimes on lymphocyte and its subpopulations in breast cancer patients.
C Yuan, Q Wang.
Clin Transl Oncol, 2018 Mar 15; 20(9). PMID: 29536332
The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules.
Kimberly M Arnold, Nicole J Flynn, +5 authors, Jennifer Sims-Mourtada.
Cancer Growth Metastasis, 2018 Mar 20; 11. PMID: 29551910    Free PMC article.
Review.
Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions.
Yifan Wang, Weiye Deng, +4 authors, Steven H Lin.
Front Pharmacol, 2018 Mar 21; 9. PMID: 29556198    Free PMC article.
Highly Cited. Review.
A prospective phase I dose-escalation trial of stereotactic ablative radiotherapy (SABR) as an alternative to cytoreductive nephrectomy for inoperable patients with metastatic renal cell carcinoma.
Rohann J M Correa, Belal Ahmad, +6 authors, Alexander V Louie.
Radiat Oncol, 2018 Mar 22; 13(1). PMID: 29558966    Free PMC article.
Galectins as Molecular Targets for Therapeutic Intervention.
Ruud P M Dings, Michelle C Miller, Robert J Griffin, Kevin H Mayo.
Int J Mol Sci, 2018 Mar 23; 19(3). PMID: 29562695    Free PMC article.
Review.
Current Strategies to Enhance Anti-Tumour Immunity.
Katherine W Cook, Lindy G Durrant, Victoria A Brentville.
Biomedicines, 2018 Mar 24; 6(2). PMID: 29570634    Free PMC article.
Review.
Immune checkpoint inhibitors in small cell lung cancer.
Suchita Pakkala, Taofeek K Owonikoko.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593891    Free PMC article.
Review.
Combining radiation plus immunotherapy to improve systemic immune response.
Taylor R Cushman, Daniel Gomez, +5 authors, James W Welsh.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593892    Free PMC article.
Review.
Beyond checkpoint inhibition - Immunotherapeutical strategies in combination with radiation.
F Eckert, U S Gaipl, +4 authors, D Zips.
Clin Transl Radiat Oncol, 2017 Feb 04; 2. PMID: 29657997    Free PMC article.
Review.
Radiotherapy and checkpoint inhibitors: a winning new combination?
Eric C Ko, Silvia C Formenti.
Ther Adv Med Oncol, 2018 Apr 18; 10. PMID: 29662550    Free PMC article.
Review.
Mechanisms of Intrinsic Tumor Resistance to Immunotherapy.
John Rieth, Subbaya Subramanian.
Int J Mol Sci, 2018 May 05; 19(5). PMID: 29724044    Free PMC article.
Review.
Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy.
Spiridon V Spirou, Sofia A Costa Lima, +8 authors, Oliviero L Gobbo.
Nanomaterials (Basel), 2018 May 08; 8(5). PMID: 29734795    Free PMC article.
Review.
Stage III non-small cell lung cancer: escalation matters, but how?
Aparna Madhukeshwar Hegde, Paul Raymond Walker.
Transl Lung Cancer Res, 2018 May 22; 7(Suppl 2). PMID: 29780703    Free PMC article.
Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination.
Jun Gong, Thang Q Le, +2 authors, Richard Tuli.
J Immunother Cancer, 2018 Jun 06; 6(1). PMID: 29866197    Free PMC article.
Review.
Proton beam therapy and immunotherapy: an emerging partnership for immune activation in non-small cell lung cancer.
Howard J Lee, Jing Zeng, Ramesh Rengan.
Transl Lung Cancer Res, 2018 Jun 08; 7(2). PMID: 29876317    Free PMC article.
Review.
Aerosol Immunotherapy with or without Cisplatin for metastatic lung cancer non-small cell lung cancer disease: In vivo Study. A more efficient combination.
Konstantinos Sapalidis, Paul Zarogoulidis, +17 authors, Naim Benhanseen.
J Cancer, 2018 Jun 14; 9(11). PMID: 29896282    Free PMC article.
Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy.
Kaiyuan Ni, Guangxu Lan, +7 authors, Wenbin Lin.
Nat Commun, 2018 Jun 17; 9(1). PMID: 29907739    Free PMC article.
Immune interconnectivity of anatomically distant tumors as a potential mediator of systemic responses to local therapy.
Rachel Walker, Jan Poleszczuk, +6 authors, Heiko Enderling.
Sci Rep, 2018 Jun 23; 8(1). PMID: 29930290    Free PMC article.
The influence of radiation in the context of developing combination immunotherapies in cancer.
Jamie Honeychurch, Timothy M Illidge.
Ther Adv Vaccines Immunother, 2018 Jul 13; 5(6). PMID: 29998216    Free PMC article.
Review.
Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma.
Inigo Martinez-Zubiaurre, Anthony J Chalmers, Turid Hellevik.
Front Immunol, 2018 Aug 15; 9. PMID: 30105016    Free PMC article.
Review.
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors.
Yang Liu, Yinping Dong, +3 authors, Jinming Yu.
J Hematol Oncol, 2018 Aug 18; 11(1). PMID: 30115069    Free PMC article.
Highly Cited. Review.
Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.
Yuzhu Hou, Hua Liang, +10 authors, Yang-Xin Fu.
Immunity, 2018 Sep 02; 49(3). PMID: 30170810    Free PMC article.
Outcomes and toxicity of stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab.
Adam C Olson, Samantha Thomas, +4 authors, April Ks Salama.
Melanoma Manag, 2016 Sep 01; 3(3). PMID: 30190887    Free PMC article.
Combining immunotherapy with radiation therapy in thoracic oncology.
Shahed N Badiyan, Michael C Roach, +7 authors, Charles B Simone.
J Thorac Dis, 2018 Sep 13; 10(Suppl 21). PMID: 30206494    Free PMC article.
Review.
δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8+ T cell activation.
Fei Huang, Junying Chen, +5 authors, Lengxi Fu.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221043    Free PMC article.
Stereotactic Body Radiation Therapy for Spinal Malignancies.
Virginia W Osborn, Anna Lee, Yoshiya Yamada.
Technol Cancer Res Treat, 2018 Oct 23; 17. PMID: 30343661    Free PMC article.
Review.
Generating antitumor immunity by targeted radiation therapy: Role of dose and fractionation.
Eric C Ko, Kimberly Thomas Benjamin, Silvia C Formenti.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370347    Free PMC article.
Review.
Exploring optimal sequencing of radiation and immunotherapy combinations.
Andrew J Gunderson, Kristina H Young.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370348    Free PMC article.
Review.
Role of the immunosuppressive microenvironment in immunotherapy.
Garth W Tormoen, Marka R Crittenden, Michael J Gough.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370351    Free PMC article.
Review.
Hyperuricaemic UrahPlt2/Plt2 mice show altered T cell proliferation and defective tumor immunity after local immunotherapy with Poly I:C.
Camille Baey, Jianping Yang, Franca Ronchese, Jacquie L Harper.
PLoS One, 2018 Nov 02; 13(11). PMID: 30383838    Free PMC article.
Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade.
Keaton I Jones, Jiske Tiersma, +4 authors, Ruth J Muschel.
EMBO Mol Med, 2018 Nov 18; 10(12). PMID: 30442705    Free PMC article.
The concept of rapid rescue radiosurgery in the acute management of critically located brain metastases: A retrospective short-term outcome analysis.
Georges Sinclair, Hamza Benmakhlouf, +2 authors, Ernest Dodoo.
Surg Neurol Int, 2018 Dec 07; 9. PMID: 30505620    Free PMC article.
Inhibition of MEK with trametinib enhances the efficacy of anti-PD-L1 inhibitor by regulating anti-tumor immunity in head and neck squamous cell carcinoma.
Seong-Ho Kang, Bhumsuk Keam, +5 authors, Dae Seog Heo.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546955    Free PMC article.
Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells.
Julia Krombach, Roman Hennel, +12 authors, Kirsten Lauber.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546963    Free PMC article.
Future of Radiotherapy in Nasopharyngeal Carcinoma.
Xue-Song Sun, Xiao-Yun Li, +2 authors, Hai-Qiang Mai.
Br J Radiol, 2019 Jul 03; 92(1102). PMID: 31265322    Free PMC article.
Radiation as an In Situ Auto-Vaccination: Current Perspectives and Challenges.
Taichiro Goto.
Vaccines (Basel), 2019 Aug 29; 7(3). PMID: 31455032    Free PMC article.
Review.
A preliminary Study on the Effect of Head and Neck Chemoradiotherapy on Systematic Immunity.
Weiqiang Huang, Yao Fan, +5 authors, Jian Guan.
Dose Response, 2019 Nov 07; 17(4). PMID: 31695581    Free PMC article.
Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma.
Peng Zhang, Jason Miska, +11 authors, Maciej S Lesniak.
Proc Natl Acad Sci U S A, 2019 Nov 13; 116(47). PMID: 31712430    Free PMC article.
Retuning the Radio in Radiobiology.
Steven J Chmura, Philip P Connell, Ralph R Weichselbaum.
J Natl Cancer Inst, 2017 Nov 11; 110(4). PMID: 29126281    Free PMC article.
Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer.
Jian Ye, Bradley N Mills, +8 authors, Scott A Gerber.
Cancer Immunol Res, 2019 Nov 14; 8(1). PMID: 31719057    Free PMC article.
Peptides of tetraspanin oncoprotein CD151 trigger active immunity against primary tumour and experimental lung metastasis.
Wanzun Lin, Jun Liu, +6 authors, Junxin Wu.
EBioMedicine, 2019 Nov 02; 49. PMID: 31668880    Free PMC article.
Amplifying Outcomes: Checkpoint Inhibitor Combinations in First-Line Non-Small Cell Lung Cancer.
Barbara Melosky, Rosalyn Juergens, +5 authors, Quincy Chu.
Oncologist, 2019 May 30; 25(1). PMID: 31138727    Free PMC article.
Directing Traffic: How to Effectively Drive T Cells into Tumors.
Annabelle J Anandappa, Catherine J Wu, Patrick A Ott.
Cancer Discov, 2020 Jan 25; 10(2). PMID: 31974169    Free PMC article.
Review.
Prognosis and Risk Factors of Radiation-Induced Lymphopenia in Early-Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy.
Qianqian Zhao, Tingting Li, +2 authors, Jian He.
Front Oncol, 2020 Feb 11; 9. PMID: 32039000    Free PMC article.
HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer.
Sayuri Miyauchi, P Dominick Sanders, +7 authors, Andrew B Sharabi.
Cancer Res, 2019 Dec 19; 80(4). PMID: 31848196    Free PMC article.
Radiotherapy as a Backbone for Novel Concepts in Cancer Immunotherapy.
Julijan Kabiljo, Felix Harpain, Sebastian Carotta, Michael Bergmann.
Cancers (Basel), 2020 Jan 08; 12(1). PMID: 31905723    Free PMC article.
Review.
Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma-unique pathological features of the primary specimen: A case report.
Kanta Hori, Yoshihiko Hirohashi, +7 authors, Ken Morita.
Exp Ther Med, 2020 Feb 28; 19(3). PMID: 32104247    Free PMC article.
Hypofractionated Irradiation Suppressed the Off-Target Mouse Hepatocarcinoma Growth by Inhibiting Myeloid-Derived Suppressor Cell-Mediated Immune Suppression.
Junying Chen, Zeng Wang, +11 authors, Lurong Zhang.
Front Oncol, 2020 Mar 03; 10. PMID: 32117702    Free PMC article.
STING, DCs and the link between innate and adaptive tumor immunity.
Ralph E Vatner, Edith M Janssen.
Mol Immunol, 2017 Dec 24; 110. PMID: 29273394    Free PMC article.
Review.
Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy.
Ariel E Marciscano, Ali Ghasemzadeh, +18 authors, Charles G Drake.
Clin Cancer Res, 2018 Jun 15; 24(20). PMID: 29898992    Free PMC article.
Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect.
María E Rodríguez-Ruiz, Claire Vanpouille-Box, +2 authors, Sandra Demaria.
Trends Immunol, 2018 Jul 14; 39(8). PMID: 30001871    Free PMC article.
Highly Cited. Review.
A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours.
Amit Maity, Rosemarie Mick, +17 authors, Robert H Vonderheide.
Br J Cancer, 2018 Oct 16; 119(10). PMID: 30318516    Free PMC article.
The Reciprocity between Radiotherapy and Cancer Immunotherapy.
Yifan Wang, Zhi-Gang Liu, +6 authors, Wen Jiang.
Clin Cancer Res, 2018 Nov 11; 25(6). PMID: 30413527    Free PMC article.
Review.
Combination Strategies to Optimize Efficacy of Dendritic Cell-Based Immunotherapy.
Mandy van Gulijk, Floris Dammeijer, Joachim G J V Aerts, Heleen Vroman.
Front Immunol, 2018 Dec 21; 9. PMID: 30568653    Free PMC article.
Review.
Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?
Ruben S A Goedegebuure, Leonie K de Klerk, +2 authors, Victor L J L Thijssen.
Front Immunol, 2019 Jan 30; 9. PMID: 30692993    Free PMC article.
Review.
Combination treatment with hypofractionated radiotherapy plus IL-2/anti-IL-2 complexes and its theranostic evaluation.
Hua Jing, Michael Hettich, +3 authors, Gabriele Niedermann.
J Immunother Cancer, 2019 Feb 28; 7(1). PMID: 30808414    Free PMC article.
Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment.
Hari Menon, Rishab Ramapriyan, +13 authors, James W Welsh.
Front Immunol, 2019 Mar 05; 10. PMID: 30828330    Free PMC article.
Highly Cited. Review.
Immunologic Consequences of Sequencing Cancer Radiotherapy and Surgery.
Juan Carlos López Alfonso, Jan Poleszczuk, +7 authors, Heiko Enderling.
JCO Clin Cancer Inform, 2019 Apr 10; 3. PMID: 30964698    Free PMC article.
First-ever Abscopal Effect after Palliative Radiotherapy and Immuno-gene Therapy for Malignant Pleural Mesothelioma.
Andrew R Barsky, Keith A Cengel, +2 authors, Charles B Simone.
Cureus, 2019 May 07; 11(2). PMID: 31057996    Free PMC article.
Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system.
Claire Lhuillier, Nils-Petter Rudqvist, +2 authors, Sandra Demaria.
Genome Med, 2019 Jun 22; 11(1). PMID: 31221199    Free PMC article.
Highly Cited. Review.
Neoantigen vaccine: an emerging tumor immunotherapy.
Miao Peng, Yongzhen Mo, +10 authors, Zhaoyang Zeng.
Mol Cancer, 2019 Aug 25; 18(1). PMID: 31443694    Free PMC article.
Highly Cited. Review.
Tumor-reprogrammed resident T cells resist radiation to control tumors.
Ainhoa Arina, Michael Beckett, +13 authors, Ralph R Weichselbaum.
Nat Commun, 2019 Sep 04; 10(1). PMID: 31477729    Free PMC article.
Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration.
Jieyu Xu, Yuan Luo, +11 authors, Conghua Xie.
Int J Biol Sci, 2020 Apr 01; 16(9). PMID: 32226302    Free PMC article.
Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors.
Franziska Eckert, Kerstin Zwirner, +3 authors, Stephan M Huber.
Front Immunol, 2019 Apr 02; 10. PMID: 30930892    Free PMC article.
Review.
A2AR Antagonism with DZD2269 Augments Antitumor Efficacy of Irradiation in Murine Model.
Jiaqi Huang, Di Zhang, +3 authors, Jinming Yu.
J Cancer, 2020 Apr 15; 11(12). PMID: 32284765    Free PMC article.
Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation.
Minhui Chen, Guanxi Qiao, +5 authors, Elizabeth A Repasky.
Nat Commun, 2020 Apr 15; 11(1). PMID: 32286326    Free PMC article.
Editorial: Combinatorial Approaches to Enhance Anti-tumor Immunity: Focus on Immune Checkpoint Blockade Therapy.
Patrik Andersson, Christian Ostheimer.
Front Immunol, 2019 Sep 27; 10. PMID: 31555290    Free PMC article.
Development of Tumor Cell-Based Vaccine with IL-12 Gene Electrotransfer as Adjuvant.
Tinkara Remic, Gregor Sersa, +2 authors, Urska Kamensek.
Vaccines (Basel), 2020 Mar 04; 8(1). PMID: 32121641    Free PMC article.
Intratumoral Gene Electrotransfer of Plasmid DNA Encoding shRNA against Melanoma Cell Adhesion Molecule Radiosensitizes Tumors by Antivascular Effects and Activation of an Immune Response.
Simona Kranjc Brezar, Valter Mrak, +3 authors, Maja Cemazar.
Vaccines (Basel), 2020 Mar 25; 8(1). PMID: 32204304    Free PMC article.
Bioengineering of Metal-organic Frameworks for Nanomedicine.
Yuan Liu, Yanli Zhao, Xiaoyuan Chen.
Theranostics, 2019 Jun 28; 9(11). PMID: 31244945    Free PMC article.
Review.
Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment.
Hiro Sato, Noriyuki Okonogi, Takashi Nakano.
Int J Clin Oncol, 2020 Apr 05; 25(5). PMID: 32246277    Free PMC article.
Review.
Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer.
Kazue Yoneda, Taiji Kuwata, +7 authors, Fumihiro Tanaka.
Br J Cancer, 2019 Aug 08; 121(6). PMID: 31388183    Free PMC article.
Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy.
Michael J Gough, Shay Sharon, Marka R Crittenden, Kristina H Young.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381295    Free PMC article.
Review.
Novel Radiation Therapy Paradigms and Immunomodulation: Heresies and Hope.
Suparna Dutt, Mansoor M Ahmed, Billy W Loo, Samuel Strober.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381299    Free PMC article.
Review.
A Pilot Feasibility Study of Yttrium-90 Liver Radioembolization Followed by Durvalumab and Tremelimumab in Patients with Microsatellite Stable Colorectal Cancer Liver Metastases.
Chongkai Wang, John Park, +12 authors, Marwan Fakih.
Oncologist, 2019 Dec 21; 25(5). PMID: 31857446    Free PMC article.
The abscopal effect 67 years later: from a side story to center stage.
Sandra Demaria, Silvia C Formenti.
Br J Radiol, 2020 Feb 27; 93(1109). PMID: 32101479    Free PMC article.
Review.
Radiation Exposure-Induced Changes in the Immune Cells and Immune Factors of Mice With or Without Primary Lung Tumor.
Shuxian Pan, Jingjie Wang, +11 authors, Wentao Hu.
Dose Response, 2020 Jun 04; 18(2). PMID: 32489339    Free PMC article.
Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma.
Brendan Curti, Marka Crittenden, +8 authors, Walter J Urba.
J Immunother Cancer, 2020 May 30; 8(1). PMID: 32467299    Free PMC article.
Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations.
Todd A Aguilera, Eslam A Elghonaimy, +10 authors, Amato J Giaccia.
Clin Cancer Res, 2020 Feb 27; 26(12). PMID: 32098769    Free PMC article.
Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model.
Ping Zhang, Audrey Darmon, +2 authors, Sébastien Paris.
Int J Nanomedicine, 2020 Jun 26; 15. PMID: 32581534    Free PMC article.
Novel Immunotherapeutic Approaches in Head and Neck Cancer.
M E Heft Neal, C T Haring, +3 authors, P L Swiecicki.
J Cancer Metastasis Treat, 2019 Jan 01; 5. PMID: 32661502    Free PMC article.
Translating the Immunobiology of SBRT to Novel Therapeutic Combinations for Advanced Prostate Cancer.
Victor R Adorno Febles, Seth Blacksburg, Jonathan A Haas, David R Wise.
Front Oncol, 2020 Jul 17; 10. PMID: 32670868    Free PMC article.
Review.
Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models.
Steven N Seyedin, M M Hasibuzzaman, +8 authors, Joseph M Caster.
Int J Radiat Oncol Biol Phys, 2020 Feb 10; 108(1). PMID: 32036006    Free PMC article.
Radiation-induced bystander and abscopal effects: important lessons from preclinical models.
Elisabeth Daguenet, Safa Louati, +6 authors, Nicolas Magné.
Br J Cancer, 2020 Jun 26; 123(3). PMID: 32581341    Free PMC article.
Review.
Research Progress and Existing Problems for Abscopal Effect.
Di Wang, Xia Zhang, +6 authors, Jinming Yu.
Cancer Manag Res, 2020 Aug 18; 12. PMID: 32801902    Free PMC article.
Review.
A Current Review of Spatial Fractionation: Back to the Future?
Cole Billena, Atif J Khan.
Int J Radiat Oncol Biol Phys, 2019 Jan 27; 104(1). PMID: 30684666    Free PMC article.
Review.
Thoracic radiotherapy plus Durvalumab in elderly and/or frail NSCLC stage III patients unfit for chemotherapy - employing optimized (hypofractionated) radiotherapy to foster durvalumab efficacy: study protocol of the TRADE-hypo trial.
Farastuk Bozorgmehr, Inn Chung, +6 authors, Stefan Rieken.
BMC Cancer, 2020 Aug 28; 20(1). PMID: 32842974    Free PMC article.
The Proteomic Effects of Pulsed Focused Ultrasound on Tumor Microenvironments of Murine Melanoma and Breast Cancer Models.
Omer Aydin, Parwathy Chandran, +3 authors, Joseph A Frank.
Ultrasound Med Biol, 2019 Sep 19; 45(12). PMID: 31530419    Free PMC article.
Immune Checkpoint Inhibitors in pMMR Metastatic Colorectal Cancer: A Tough Challenge.
Federica Marmorino, Alessandra Boccaccino, +2 authors, Chiara Cremolini.
Cancers (Basel), 2020 Aug 23; 12(8). PMID: 32824490    Free PMC article.
Review.
A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice.
Nadja Salomon, Fulvia Vascotto, +9 authors, Sebastian Kreiter.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923128    Free PMC article.
Radiotherapy as a New Player in Immuno-Oncology.
Shang-Jui Wang, Bruce Haffty.
Cancers (Basel), 2018 Dec 19; 10(12). PMID: 30558196    Free PMC article.
Review.
Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation.
Zachary S Buchwald, Jacob Wynne, +6 authors, Mohammad K Khan.
Front Oncol, 2019 Jan 09; 8. PMID: 30619752    Free PMC article.
Highly Cited. Review.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma.
Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns.
Front Oncol, 2019 Mar 12; 8. PMID: 30854331    Free PMC article.
Review.
Combining Radiation and Immune Checkpoint Blockade in the Treatment of Head and Neck Squamous Cell Carcinoma.
Gregor Manukian, Voichita Bar-Ad, +2 authors, Jennifer M Johnson.
Front Oncol, 2019 Mar 22; 9. PMID: 30895168    Free PMC article.
Review.
Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.
Maxim Shevtsov, Hiro Sato, Gabriele Multhoff, Atsushi Shibata.
Front Oncol, 2019 Apr 04; 9. PMID: 30941308    Free PMC article.
Review.
Turning "Cold" Into "Hot" Tumors-Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers.
Lisa Sevenich.
Front Oncol, 2019 Apr 04; 9. PMID: 30941312    Free PMC article.
Review.
Radiotherapy Both Promotes and Inhibits Myeloid-Derived Suppressor Cell Function: Novel Strategies for Preventing the Tumor-Protective Effects of Radiotherapy.
Suzanne Ostrand-Rosenberg, Lucas A Horn, Nicholas G Ciavattone.
Front Oncol, 2019 Apr 20; 9. PMID: 31001479    Free PMC article.
Review.
Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas.
Jean Philippe Nesseler, Dorthe Schaue, +4 authors, Philippe Nickers.
Adv Radiat Oncol, 2019 Apr 24; 4(2). PMID: 31011672    Free PMC article.
Review.
Enhancing Dendritic Cell Therapy in Solid Tumors with Immunomodulating Conventional Treatment.
Robert A Belderbos, Joachim G J V Aerts, Heleen Vroman.
Mol Ther Oncolytics, 2019 Apr 26; 13. PMID: 31020037    Free PMC article.
Review.
The rationale for including immune checkpoint inhibition into multimodal primary treatment concepts of head and neck cancer.
Ingeborg Tinhofer, Volker Budach, Korinna Jöhrens, Ulrich Keilholz.
Cancers Head Neck, 2016 Aug 10; 1. PMID: 31093338    Free PMC article.
Review.
Extracranial Abscopal Responses after Radiation Therapy for Intracranial Metastases: A Review of the Clinical Literature and Commentary on Mechanism.
Chengcheng Gui, Lawrence R Kleinberg, Michael Lim, Kristin J Redmond.
Cureus, 2019 May 23; 11(3). PMID: 31114726    Free PMC article.
Review.
Radiotherapy in Combination With Cytokine Treatment.
Ondrej Palata, Nada Hradilova Podzimkova, +5 authors, Irena Adkins.
Front Oncol, 2019 Jun 11; 9. PMID: 31179236    Free PMC article.
Review.
The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors.
Malek Kreidieh, Youssef H Zeidan, Ali Shamseddine.
J Oncol, 2019 Jun 12; 2019. PMID: 31182960    Free PMC article.
Review.
Immunotherapy in urothelial cancer, part 2: adjuvant, neoadjuvant, and adjunctive treatment.
Steven S Yu, Leslie K Ballas, +3 authors, David I Quinn.
Clin Adv Hematol Oncol, 2017 Jul 28; 15(7). PMID: 28749918    Free PMC article.
Review.
CDK4/6 inhibitors: a novel strategy for tumor radiosensitization.
Yilan Yang, Jurui Luo, +6 authors, Xiaoli Yu.
J Exp Clin Cancer Res, 2020 Sep 17; 39(1). PMID: 32933570    Free PMC article.
Review.
Prognostic Values of Radiosensitivity Genes and CD19 Status in Gastric Cancer: A Retrospective Study Using TCGA Database.
Li-Bo Liang, Xin-Yan Huang, He He, Ji-Yan Liu.
Pharmgenomics Pers Med, 2020 Sep 29; 13. PMID: 32982372    Free PMC article.
Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.
Anne Ernst, Roman Hennel, +13 authors, Kirsten Lauber.
Front Oncol, 2020 Sep 29; 10. PMID: 32984042    Free PMC article.
Enhancing the efficacy of immunotherapy using radiotherapy.
Synat Keam, Suki Gill, +2 authors, Alistair M Cook.
Clin Transl Immunology, 2020 Oct 01; 9(9). PMID: 32994997    Free PMC article.
Review.
Radiation induces dynamic changes to the T cell repertoire in renal cell carcinoma patients.
Jacky Chow, Nicholas C Hoffend, +3 authors, Jason B Muhitch.
Proc Natl Acad Sci U S A, 2020 Sep 10; 117(38). PMID: 32900949    Free PMC article.
Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model.
Yiannis Philippou, Hanna T Sjoberg, +16 authors, Richard J Bryant.
Br J Cancer, 2020 Jul 10; 123(7). PMID: 32641865    Free PMC article.
Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights into Stromal-Mediated Radioresistance.
Varintra E Krisnawan, Jennifer A Stanley, Julie K Schwarz, David G DeNardo.
Cancers (Basel), 2020 Oct 15; 12(10). PMID: 33050580    Free PMC article.
Review.
Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s.
Takaaki Oba, Mark D Long, +5 authors, Fumito Ito.
Nat Commun, 2020 Oct 29; 11(1). PMID: 33110069    Free PMC article.
Chemotherapy-based split stereotactic body radiation therapy for borderline resectable and locally advanced pancreatic cancer: study protocol of a prospective, single-arm phase II trial.
Rong Zheng, Congfei Wang, +5 authors, Benhua Xu.
BMJ Open, 2020 Nov 07; 10(11). PMID: 33154057    Free PMC article.
Immunomodulatory Effects of Radiotherapy.
Sharda Kumari, Shibani Mukherjee, +3 authors, Aroumougame Asaithamby.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142765    Free PMC article.
Review.
A narrative review of synergistic drug administration in unresectable locally advanced non-small cell lung cancer: current landscape and future prospects in the era of immunotherapy.
Shuyan Li, Xiao Chu, +2 authors, Zhengfei Zhu.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209628    Free PMC article.
Review.
The Impact of Radiation-Induced DNA Damage on cGAS-STING-Mediated Immune Responses to Cancer.
Quinn Storozynsky, Mary M Hitt.
Int J Mol Sci, 2020 Nov 27; 21(22). PMID: 33238631    Free PMC article.
Review.
Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma.
Houda Bahig, Francine Aubin, +14 authors, Philip Wong.
BMC Cancer, 2019 Jan 16; 19(1). PMID: 30642290    Free PMC article.
Time for radioimmunotherapy: an overview to bring improvements in clinical practice.
O Leaman Alcibar, D Candini, +9 authors, M E Rodríguez-Ruiz.
Clin Transl Oncol, 2019 Jan 16; 21(8). PMID: 30644044
Review.
Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy.
Bernardo L Rapoport, Ronald Anderson.
Int J Mol Sci, 2019 Mar 01; 20(4). PMID: 30813267    Free PMC article.
Highly Cited. Review.
Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer.
Di Maria Jiang, Anthony Fyles, +6 authors, Srikala S Sridhar.
Oncotarget, 2019 May 21; 10(31). PMID: 31105877    Free PMC article.
Treatment-duration is related to changes in peripheral lymphocyte counts during definitive radiotherapy for unresectable stage III NSCLC.
Qianqian Zhao, Gang Chen, +4 authors, Jian He.
Radiat Oncol, 2019 May 28; 14(1). PMID: 31133034    Free PMC article.
Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma.
Changhoon Choi, Gyu Sang Yoo, Won Kyung Cho, Hee Chul Park.
World J Gastroenterol, 2019 Jun 07; 25(20). PMID: 31171886    Free PMC article.
Review.
Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines.
Laura Hartmann, Philipp Schröter, +8 authors, Stefan B Eichmüller.
Sci Rep, 2020 Dec 11; 10(1). PMID: 33299018    Free PMC article.
Predictors of immunotherapy benefit in Merkel cell carcinoma.
Alec J Kacew, Harita Dharaneeswaran, +5 authors, Glenn J Hanna.
Oncotarget, 2020 Dec 15; 11(47). PMID: 33315984    Free PMC article.
Rationale for concurrent chemoradiotherapy for patients with stage III non-small-cell lung cancer.
John Conibear, AstraZeneca UK Limited.
Br J Cancer, 2020 Dec 10; 123(Suppl 1). PMID: 33293671    Free PMC article.
Review.
Enhancing Combined Immunotherapy and Radiotherapy through Nanomedicine.
C Tilden Hagan, Yu Mi, Nicole M Knape, Andrew Z Wang.
Bioconjug Chem, 2020 Dec 01; 31(12). PMID: 33251789    Free PMC article.
Review.
Immune Checkpoint Inhibitors in Advanced Acral Melanoma: A Systematic Review.
Qingyue Zheng, Jiarui Li, +2 authors, Shu Zhang.
Front Oncol, 2020 Dec 22; 10. PMID: 33344255    Free PMC article.
Systematic Review.
Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts.
Rachel A Woolaver, Xiaoguang Wang, +9 authors, Jing Hong Wang.
J Immunother Cancer, 2021 Jan 09; 9(1). PMID: 33414263    Free PMC article.
Combining radiation therapy and immunotherapy for lung cancers: a narrative review.
Chirag Modi, Lyudmyla Berim, +6 authors, Salma K Jabbour.
Shanghai Chest, 2021 Feb 02; 5. PMID: 33521559    Free PMC article.
Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer.
Jacob Gadwa, Sana D Karam.
Int J Radiat Oncol Biol Phys, 2020 Jul 07; 108(1). PMID: 32629082    Free PMC article.
Review.
Radiotherapy-Immunotherapy Combination: How Will We Bridge the Gap Between Pre-Clinical Promise and Effective Clinical Delivery?
Erminia Romano, Jamie Honeychurch, Timothy M Illidge.
Cancers (Basel), 2021 Feb 04; 13(3). PMID: 33530329    Free PMC article.
Review.
Combinations using checkpoint blockade to overcome resistance.
Stefania Morganti, Giuseppe Curigliano.
Ecancermedicalscience, 2021 Feb 13; 14. PMID: 33574893    Free PMC article.
Review.
Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation.
Travis T Sims, Molly B El Alam, +21 authors, Ann H Klopp.
Commun Biol, 2021 Feb 24; 4(1). PMID: 33619320    Free PMC article.
Enhance the Immune Checkpoint Inhibitors Efficacy with Radiotherapy Induced Immunogenic Cell Death: A Comprehensive Review and Latest Developments.
Adrien Procureur, Audrey Simonaggio, +2 authors, Yann-Alexandre Vano.
Cancers (Basel), 2021 Feb 12; 13(4). PMID: 33567530    Free PMC article.
Review.
Combined Treatment of Radiotherapy and Immunotherapy for Urological Malignancies: Current Evidence and Clinical Considerations.
Haoran Lei, Ming Shi, +4 authors, Lu Yang.
Cancer Manag Res, 2021 Mar 05; 13. PMID: 33658847    Free PMC article.
Review.
Beyond immune checkpoint blockade: emerging immunological strategies.
Shawn P Kubli, Thorsten Berger, +2 authors, Tak W Mak.
Nat Rev Drug Discov, 2021 Mar 10; 20(12). PMID: 33686237
Review.
A Prospective, Phase 1 Trial of Nivolumab, Ipilimumab, and Radiotherapy in Patients with Advanced Melanoma.
Michael A Postow, Susan J Knox, +22 authors, Christopher A Barker.
Clin Cancer Res, 2020 Mar 25; 26(13). PMID: 32205463    Free PMC article.
Hyperprogressive disease after radiotherapy combined with anti-PD-1 therapy in renal cell carcinoma: a case report and review of the literature.
Chao Liu, Jingjing Piao, Zhiyang Shang.
BMC Urol, 2021 Mar 22; 21(1). PMID: 33743675    Free PMC article.
Review.
A combination of PD‑1/PD‑L1 inhibitors: The prospect of overcoming the weakness of tumor immunotherapy (Review).
Xianbin Kong, Peng Lu, +8 authors, Jingyan Meng.
Mol Med Rep, 2021 Mar 25; 23(5). PMID: 33760188    Free PMC article.
Review.
Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer.
Incheol Seo, Hye Won Lee, +6 authors, Sung Uk Bae.
J Immunother Cancer, 2021 Mar 12; 9(3). PMID: 33692216    Free PMC article.
Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma.
Byung Min Lee, Jinsil Seong.
World J Gastroenterol, 2021 Mar 30; 27(10). PMID: 33776363    Free PMC article.
Review.
Harnessing the potential of multimodal radiotherapy in prostate cancer.
Yiannis Philippou, Hanna Sjoberg, +2 authors, Richard J Bryant.
Nat Rev Urol, 2020 May 03; 17(6). PMID: 32358562
Review.
Improving Anti-PD-1/PD-L1 Therapy for Localized Bladder Cancer.
Florus C de Jong, Vera C Rutten, Tahlita C M Zuiverloon, Dan Theodorescu.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33802033    Free PMC article.
Review.
Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy.
Damiënne Marcus, Relinde I Y Lieverse, +4 authors, Ala Yaromina.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33806808    Free PMC article.
Review.
Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel.
Thomas P Brouwer, Alexander L Vahrmeijer, Noel F C C de Miranda.
Cell Oncol (Dordr), 2021 Mar 13; 44(2). PMID: 33710604    Free PMC article.
Review.
Impact of reirradiation, chemotherapy, and immunotherapy on survival of patients with recurrent lung cancer: A single-center retrospective analysis.
Brane Grambozov, Romana Wass, +6 authors, Franz Zehentmayr.
Thorac Cancer, 2021 Feb 16; 12(8). PMID: 33586228    Free PMC article.
Cancer Vaccines, Adjuvants, and Delivery Systems.
Samantha J Paston, Victoria A Brentville, Peter Symonds, Lindy G Durrant.
Front Immunol, 2021 Apr 17; 12. PMID: 33859638    Free PMC article.
Review.
Ipilimumab and Stereotactic Radiosurgery with CyberKnife® System in Melanoma Brain Metastases: A Retrospective Monoinstitutional Experience.
Valentina Borzillo, Rossella Di Franco, +15 authors, Paolo Muto.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33924595    Free PMC article.
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Sadna Budhu, Rachel Giese, +13 authors, Taha Merghoub.
Cell Rep, 2021 Jan 14; 34(2). PMID: 33440157    Free PMC article.
Nivolumab and Hypofractionated Radiotherapy in Patients With Advanced Lung Cancer: ABSCOPAL-1 Clinical Trial.
Hua Ye, Haowen Pang, +5 authors, Sheng Lin.
Front Oncol, 2021 May 11; 11. PMID: 33968760    Free PMC article.
Immunotherapy Combined With Radiation Therapy for Genitourinary Malignancies.
Jacob Ukleja, Erika Kusaka, David T Miyamoto.
Front Oncol, 2021 May 28; 11. PMID: 34041029    Free PMC article.
Review.
Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio.
Marike W van Gisbergen, Emma Zwilling, Ludwig J Dubois.
Front Oncol, 2021 May 28; 11. PMID: 34041023    Free PMC article.
Review.
Valproic Acid-Like Compounds Enhance and Prolong the Radiotherapy Effect on Breast Cancer by Activating and Maintaining Anti-Tumor Immune Function.
Zuchao Cai, David Lim, +9 authors, Zhihui Feng.
Front Immunol, 2021 Jun 01; 12. PMID: 34054811    Free PMC article.
In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models.
Takaaki Oba, Kenichi Makino, +7 authors, Fumito Ito.
J Immunother Cancer, 2021 May 30; 9(5). PMID: 34049930    Free PMC article.
Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice.
Alexander A Pieper, Alexander L Rakhmilevich, +10 authors, Paul M Sondel.
J Immunother Cancer, 2021 Jun 27; 9(6). PMID: 34172518    Free PMC article.
Angiogenesis and immune checkpoint dual blockade in combination with radiotherapy for treatment of solid cancers: opportunities and challenges.
Lingling Zhu, Xianzhe Yu, +6 authors, Qinghua Zhou.
Oncogenesis, 2021 Jul 12; 10(7). PMID: 34247198    Free PMC article.
Review.
Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review.
Caressa Hui, Brittney Chau, +3 authors, Arya Amini.
Front Oncol, 2021 Jul 20; 11. PMID: 34277390    Free PMC article.
Review.
A narrative review of combined stereotactic ablative radiotherapy and immunotherapy in metastatic non-small cell lung cancer.
Zarique Z Akanda, Paul J Neeson, +5 authors, Shankar Siva.
Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295676    Free PMC article.
Review.
Microbeam Radiotherapy-A Novel Therapeutic Approach to Overcome Radioresistance and Enhance Anti-Tumour Response in Melanoma.
Verdiana Trappetti, Jennifer M Fazzari, +4 authors, Valentin G Djonov.
Int J Mol Sci, 2021 Jul 25; 22(14). PMID: 34299373    Free PMC article.
Review.
Prognostic Roles of Phosphofructokinase Platelet in Clear Cell Renal Cell Carcinoma and Correlation with Immune Infiltration.
Bin Liu, Faping Li, +4 authors, Honglan Zhou.
Int J Gen Med, 2021 Jul 30; 14. PMID: 34321910    Free PMC article.
Targeted Alpha-Particle Radiotherapy and Immune Checkpoint Inhibitors Induces Cooperative Inhibition on Tumor Growth of Malignant Melanoma.
Mengshi Li, Dijie Liu, +8 authors, Michael K Schultz.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359580    Free PMC article.
Pre-treatment tumor-infiltrating T cells influence response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma.
R S A Goedegebuure, M Harrasser, +15 authors, S Derks.
Oncoimmunology, 2021 Aug 12; 10(1). PMID: 34377591    Free PMC article.
The Clinical Application of Neoantigens in Esophageal Cancer.
Yi-Min Gu, Yue Zhuo, Long-Qi Chen, Yong Yuan.
Front Oncol, 2021 Aug 14; 11. PMID: 34386424    Free PMC article.
Review.
Current and future drug combination strategies based on programmed death-1/programmed death-ligand 1 inhibitors in non-small cell lung cancer.
Ying Cheng, Hui Li, +3 authors, Shuang Zhang.
Chin Med J (Engl), 2021 Jun 17; 134(15). PMID: 34133356    Free PMC article.
Review.
Multimodal Intralesional Therapy for Reshaping the Myeloid Compartment of Tumors Resistant to Anti-PD-L1 Therapy via IRF8 Expression.
Ankit Patel, Takaaki Oba, +3 authors, Fumito Ito.
J Immunol, 2021 Aug 08; 207(5). PMID: 34362833    Free PMC article.
Prospective Evaluation of Radiotherapy-Induced Immunologic and Genetic Effects in Colorectal Cancer Oligo-Metastatic Patients with Lung-Limited Disease: The PRELUDE-1 Study.
Alessandro Ottaiano, Angela Petito, +35 authors, Paolo Muto.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439390    Free PMC article.
Cytoreductive stereotactic body radiotherapy (SBRT) and combination SBRT with immune checkpoint inhibitors in metastatic renal cell carcinoma.
Jonathan Peng, Aly-Khan Lalani, Anand Swaminath.
Can Urol Assoc J, 2021 Jan 08; 15(8). PMID: 33410742    Free PMC article.
Review.
Hypoxia in Solid Tumors: How Low Oxygenation Impacts the "Six Rs" of Radiotherapy.
Andria Rakotomalala, Alexandre Escande, +2 authors, Eric Lartigau.
Front Endocrinol (Lausanne), 2021 Sep 21; 12. PMID: 34539584    Free PMC article.
Review.
Forecasting Individual Patient Response to Radiation Therapy in Head and Neck Cancer With a Dynamic Carrying Capacity Model.
Mohammad U Zahid, Nuverah Mohsin, +5 authors, Heiko Enderling.
Int J Radiat Oncol Biol Phys, 2021 Jun 09; 111(3). PMID: 34102299    Free PMC article.
Combination strategies to maximize the benefits of cancer immunotherapy.
Shaoming Zhu, Tian Zhang, +5 authors, Chong-Xian Pan.
J Hematol Oncol, 2021 Sep 29; 14(1). PMID: 34579759    Free PMC article.
Review.
Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation.
Zhao Ma, Han Wang, +6 authors, Bo Xu.
Cancer Sci, 2021 Jul 13; 112(10). PMID: 34251713    Free PMC article.
Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer.
Neil H Segal, Andrea Cercek, +35 authors, Leonard B Saltz.
Clin Cancer Res, 2021 Jan 29; 27(8). PMID: 33504552    Free PMC article.
Tumor-immune ecosystem dynamics define an individual Radiation Immune Score to predict pan-cancer radiocurability.
Juan C L Alfonso, G Daniel Grass, +9 authors, Heiko Enderling.
Neoplasia, 2021 Oct 08; 23(11). PMID: 34619428    Free PMC article.
Abscopal Effect and Drug-Induced Xenogenization: A Strategic Alliance in Cancer Treatment?
Ornella Franzese, Francesco Torino, +8 authors, Enzo Bonmassar.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639014    Free PMC article.
Review.
Current advances in immune checkpoint inhibitor combinations with radiation therapy or cryotherapy for breast cancer.
Alice Y Ho, Shervin Tabrizi, Samantha A Dunn, Heather L McArthur.
Breast Cancer Res Treat, 2021 Oct 30; 191(2). PMID: 34714450
Review.
Advances in Combining Radiation and Immunotherapy in Breast Cancer.
Anthony T Nguyen, Stephen L Shiao, Heather L McArthur.
Clin Breast Cancer, 2021 Apr 04; 21(2). PMID: 33810972    Free PMC article.
Review.
Kickstarting Immunity in Cold Tumours: Localised Tumour Therapy Combinations With Immune Checkpoint Blockade.
Elizabeth Appleton, Jehanne Hassan, +7 authors, Erik Wennerberg.
Front Immunol, 2021 Nov 05; 12. PMID: 34733287    Free PMC article.
Review.
Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer.
Toshihiro Yokoi, Takaaki Oba, +2 authors, Fumito Ito.
Sci Rep, 2021 Nov 11; 11(1). PMID: 34754037    Free PMC article.
Efficacy of PD-1/PD-L1 inhibitors in patients with non-small cell lung cancer and brain metastases: A real-world retrospective study in China.
Jiamin Sheng, Hui Li, +7 authors, Yun Fan.
Thorac Cancer, 2021 Oct 02; 12(22). PMID: 34596346    Free PMC article.
Bridging Radiotherapy to Immunotherapy: The IFN-JAK-STAT Axis.
Lewis Zhichang Shi, James A Bonner.
Int J Mol Sci, 2021 Nov 28; 22(22). PMID: 34830176    Free PMC article.
Systematic Review.
Recent Research on Combination of Radiotherapy with Targeted Therapy or Immunotherapy in Head and Neck Squamous Cell Carcinoma: A Review for Radiation Oncologists.
Daniel Tao Xing, Richard Khor, +3 authors, Sweet Ping Ng.
Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34830871    Free PMC article.
Review.
Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect.
Sara Nava, Daniela Lisini, Simona Frigerio, Anna Bersano.
Int J Mol Sci, 2021 Nov 28; 22(22). PMID: 34830221    Free PMC article.
Review.
Phase II Evaluation of Stereotactic Ablative Radiotherapy (SABR) and Immunity in 11C-Choline-PET/CT-Identified Oligometastatic Castration-Resistant Prostate Cancer.
Henan Zhang, Jacob J Orme, +20 authors, Sean S Park.
Clin Cancer Res, 2021 Oct 02; 27(23). PMID: 34593526    Free PMC article.
Neoadjuvant In Situ Immunomodulation Enhances Systemic Antitumor Immunity against Highly Metastatic Tumors.
Takaaki Oba, Ryutaro Kajihara, +2 authors, Fumito Ito.
Cancer Res, 2021 Oct 21; 81(24). PMID: 34666993    Free PMC article.
Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity.
Yuzhu Hou, Hua L Liang, +19 authors, Ralph R Weichselbaum.
Sci Transl Med, 2021 Feb 26; 13(582). PMID: 33627484    Free PMC article.
Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer.
Nadja Salomon, Abderaouf Selmi, +9 authors, Fulvia Vascotto.
Cancer Immunol Immunother, 2022 Jan 01;. PMID: 34971406
Immune-Mediated Effects of Microplanar Radiotherapy with a Small Animal Irradiator.
Soha Bazyar, Edward Timothy O'Brien, +5 authors, Yueh Z Lee.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008319    Free PMC article.
Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.
April K S Salama, Manisha Palta, +14 authors, David M Brizel.
Clin Cancer Res, 2020 Nov 12; 27(5). PMID: 33172894    Free PMC article.
Effects of Radiation on the Tumor Microenvironment.
Arta M Monjazeb, Kurt A Schalper, +3 authors, Kristina Young.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381294    Free PMC article.
Review.
Imaging Immune Cells Using Fc Domain Probes in Mouse Cancer Xenograft Models.
Wendy Bernhard, Kris Barreto, +2 authors, C Ronald Geyer.
Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053466    Free PMC article.
Antitumor Peptide-Based Vaccine in the Limelight.
Takumi Kumai, Hidekiyo Yamaki, +3 authors, Hiroki Komatsuda.
Vaccines (Basel), 2022 Jan 23; 10(1). PMID: 35062731    Free PMC article.
Review.
Combination radiation and immunotherapy in gynecologic malignancies-a comprehensive review.
Colton Ladbury, Elizabeth Germino, +4 authors, Scott Glaser.
Transl Cancer Res, 2022 Feb 05; 10(5). PMID: 35116574    Free PMC article.
Review.
Narrative review of immunotherapy and radiation therapy in elderly patients.
Brittney Chau, Jonnby LaGuardia, +4 authors, Arya Amini.
Transl Cancer Res, 2022 Feb 05; 10(5). PMID: 35116575    Free PMC article.
Review.
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy.
Stephen L Shiao, Kathleen M Kershaw, +21 authors, David M Underhill.
Cancer Cell, 2021 Jul 31; 39(9). PMID: 34329585    Free PMC article.
Tumor-Infiltrating Lymphocytes as Biomarkers of Treatment Response and Long-Term Survival in Patients with Rectal Cancer: A Systematic Review and Meta-Analysis.
Adile Orhan, Faisal Khesrawi, +4 authors, Ismail Gögenur.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158905    Free PMC article.
Review.
Modulation of Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC.
Carlotta Cattolico, Peter Bailey, Simon T Barry.
Front Cell Dev Biol, 2022 Mar 12; 10. PMID: 35273962    Free PMC article.
Review.
Short-course radiotherapy combined with CAPOX and Toripalimab for the total neoadjuvant therapy of locally advanced rectal cancer: a randomized, prospective, multicentre, double-arm, phase II trial (TORCH).
Yaqi Wang, Lijun Shen, +8 authors, Fan Xia.
BMC Cancer, 2022 Mar 17; 22(1). PMID: 35291966    Free PMC article.
Evaluation of the impact of pre-operative stereotactic radiotherapy on the acute changes in histopathologic and immune marker profiles of brain metastases.
Rupesh Kotecha, Raees Tonse, +10 authors, Michael W McDermott.
Sci Rep, 2022 Mar 18; 12(1). PMID: 35296750    Free PMC article.
Radiobiology of stereotactic radiotherapy.
Monica Mangoni, Simona Borghesi, Cynthia Aristei, Carlotta Becherini.
Rep Pract Oncol Radiother, 2022 Apr 12; 27(1). PMID: 35402022    Free PMC article.
Review.
The Current State of Treatment and Future Directions in Cutaneous Malignant Melanoma.
Madison Ernst, Alessio Giubellino.
Biomedicines, 2022 Apr 24; 10(4). PMID: 35453572    Free PMC article.
Review.
Combining Radiotherapy and Immunotherapy in Metastatic Breast Cancer: Current Status and Future Directions.
Steven David, Jennifer Tan, +3 authors, Sherene Loi.
Biomedicines, 2022 Apr 24; 10(4). PMID: 35453571    Free PMC article.
Review.
Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model.
Mineyuki Tojo, Hideyo Miyato, +10 authors, Joji Kitayama.
Sci Rep, 2022 May 05; 12(1). PMID: 35508498    Free PMC article.
Combining bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) improves systemic antitumor CD8+ T cell cytotoxicity over BEMPEG+RT.
Annah S Rolig, Daniel C Rose, +3 authors, William L Redmond.
J Immunother Cancer, 2022 Apr 22; 10(4). PMID: 35444059    Free PMC article.
Current status and advances of immunotherapy in nasopharyngeal carcinoma.
Jian-Ying Xu, Xiao-Li Wei, Yi-Qin Wang, Feng-Hua Wang.
Ther Adv Med Oncol, 2022 May 14; 14. PMID: 35547095    Free PMC article.
Review.
The mutual relationship between the host immune system and radiotherapy: stimulating the action of immune cells by irradiation.
Tsubasa Watanabe, Genki Edward Sato, +2 authors, Takashi Mizowaki.
Int J Clin Oncol, 2022 May 14;. PMID: 35556190
Review.