Journal Article
. 2005 Aug; 3(2):79-85.
doi: 10.2463/mrms.3.79.

Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value

Yoshifumi Kuroki 1 Katsuhiro Nasu  Seiko Kuroki  Koji Murakami  Takayuki Hayashi  Ryuzou Sekiguchi  Shigeru Nawano  
Affiliations
  • PMID: 16093623
  •     56 citations

Abstract

Purpose: The usefulness of diffusion-weighted imaging (DWI) in the field of neuroradiology has been established. Despite its high contrast resolution, DWI has the disadvantages of susceptibility artifact and chemical shift artifact. We performed DWI of breast cancer with the sensitivity encoding (SENSE) technique.

Methods: The subjects were 60 female patients with breast mass. All patients underwent MRI including SENSE-DWI and were diagnosed histologically. Of these patients, 55 were diagnosed with breast cancer and the remaining five were diagnosed with benign mass. The histological diagnoses of breast cancer were as follows: 39 cases of invasive ductal carcinoma (IDC); 11 cases of IDC with a predominant intraductal component and non IDC (pure or predominant NIDC); and five cases of special types of cancer. The MR system used was a Gyroscan Intera 1.5T (Philips Medical Systems). In addition to routine MRI for breast cancer, including contrast-enhanced dynamic, SENSE-DWI was obtained. The accuracy of the positional information of SENSE-DWI was visually compared with that of conventional images. The apparent diffusion coefficient (ADC) values of breast mass were analyzed with SENSE-DWI.

Results: The accuracy of positional information was adequate for diagnosing of all patients. The mean ADC value of breast cancer was 1.021x10(-3) mm2/s and that of benign mass was 1.488x10(-3) mm2/s (p=0.0002). The mean ADC value of IDC was 0.968x10(-3) mm2/s and that of pure or predominant NIDC was 1.218x10(-3) mm2/s (p=0.0011).

Conclusion: SENSE-DWI was of sufficient quality to support diagnosis of breast mass. SENSE-DWI may permit the acquisition of more detailed information about lesions, including tumor cellularity, that is difficult to obtain with conventional techniques.

Measurement of the apparent diffusion coefficient in the liver: is it a reliable index for hepatic disease diagnosis?
Katsuhiro Nasu, Yoshifumi Kuroki, +2 authors, Hiroto Nakajima.
Radiat Med, 2006 Sep 09; 24(6). PMID: 16958425
Diffusion-weighted magnetic resonance imaging and its application to cancer.
Elizabeth M Charles-Edwards, Nandita M deSouza.
Cancer Imaging, 2006 Oct 04; 6. PMID: 17015238    Free PMC article.
Review.
Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results.
Thomas E Yankeelov, Martin Lepage, +9 authors, John C Gore.
Magn Reson Imaging, 2007 Jan 16; 25(1). PMID: 17222711    Free PMC article.
Highly Cited.
Comparison of breast cancer detection by diffusion-weighted magnetic resonance imaging and mammography.
Miho I Yoshikawa, Shozo Ohsumi, +4 authors, Teruhito Mochizuki.
Radiat Med, 2007 Jun 22; 25(5). PMID: 17581710
Optimization of b value in diffusion-weighted MRI for the differential diagnosis of benign and malignant vertebral fractures.
Guangyu Tang, Yong Liu, +3 authors, Peng Li.
Skeletal Radiol, 2007 Sep 06; 36(11). PMID: 17786434
Hepatic pseudo-anisotropy: a specific artifact in hepatic diffusion-weighted images obtained with respiratory triggering.
Katsuhiro Nasu, Yoshifumi Kuroki, Hirofumi Fujii, Manabu Minami.
MAGMA, 2007 Oct 26; 20(4). PMID: 17960439
Comparison of 3.0-and 1.5-tesla diffusion-weighted imaging in the visibility of breast cancer.
Aoi Matsuoka, Masako Minato, +5 authors, Hiromu Nishitani.
Radiat Med, 2008 Feb 01; 26(1). PMID: 18236129
Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer.
Miho I Yoshikawa, Shozo Ohsumi, +5 authors, Yutaka Imai.
Radiat Med, 2008 May 30; 26(4). PMID: 18509722
The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma.
Zhang Yili, Huang Xiaoyan, +4 authors, Guo Youmin.
BMC Cancer, 2009 Jan 16; 9. PMID: 19144163    Free PMC article.
SSH-EPI diffusion-weighted MR imaging of the spine with low b values: is it useful in differentiating malignant metastatic tumor infiltration from benign fracture edema?
Ozgur Oztekin, Ebru Ozan, +2 authors, Yusuf Abali.
Skeletal Radiol, 2009 Mar 03; 38(7). PMID: 19252906
Feasibility of diffusion-weighted imaging under split breath-hold acquisition and postprocessing (DWI-SBAP): an attempt to suppress hepatic pseudo-anisotropy.
Katsuhiro Nasu, Yoshifumi Kuroki, Manabu Minami.
Jpn J Radiol, 2009 Apr 18; 27(2). PMID: 19373536
MRI methods for evaluating the effects of tyrosine kinase inhibitor administration used to enhance chemotherapy efficiency in a breast tumor xenograft model.
S O Aliu, L J Wilmes, +4 authors, N M Hylton.
J Magn Reson Imaging, 2009 Apr 24; 29(5). PMID: 19388114    Free PMC article.
Diffusion-weighted MR imaging with background body signal suppression (DWIBS) for the diagnosis of malignant and benign breast lesions.
Andreas Stadlbauer, Reinhard Bernt, +5 authors, Erich Salomonowitz.
Eur Radiol, 2009 May 06; 19(10). PMID: 19415286
Comparison of diffusion-weighted images using short inversion time inversion recovery or chemical shift selective pulse as fat suppression in patients with breast cancer.
Toshiki Kazama, Katsuhiro Nasu, +2 authors, Hisao Ito.
Jpn J Radiol, 2009 Jun 06; 27(4). PMID: 19499306
Diffusion-weighted imaging in breast lesion evaluation.
P Belli, M Costantini, +3 authors, L Bonomo.
Radiol Med, 2009 Nov 11; 115(1). PMID: 19902330
Sensitivity and specificity of unenhanced MR mammography (DWI combined with T2-weighted TSE imaging, ueMRM) for the differentiation of mass lesions.
Pascal A T Baltzer, Matthias Benndorf, +3 authors, Werner A Kaiser.
Eur Radiol, 2009 Nov 26; 20(5). PMID: 19936758
The role of parallel diffusion-weighted imaging and apparent diffusion coefficient (ADC) map values for evaluating breast lesions: preliminary results.
Guangwei Jin, Ningyu An, Michael A Jacobs, Kuncheng Li.
Acad Radiol, 2010 Mar 09; 17(4). PMID: 20207316    Free PMC article.
FDG PET/CT and diffusion-weighted imaging for breast cancer: prognostic value of maximum standardized uptake values and apparent diffusion coefficient values of the primary lesion.
Masatoyo Nakajo, Yoriko Kajiya, +6 authors, Masayuki Nakajo.
Eur J Nucl Med Mol Imaging, 2010 Jul 08; 37(11). PMID: 20607535
Diffusion tensor magnetic resonance imaging of the breast: a pilot study.
Pascal A T Baltzer, Anja Schäfer, +4 authors, Werner A Kaiser.
Eur Radiol, 2010 Jul 30; 21(1). PMID: 20668860
Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma: Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images.
Roka Namoto Matsubayashi, Teruhiko Fujii, +2 authors, Seiya Momosaki.
J Oncol, 2010 Sep 28; 2010. PMID: 20871661    Free PMC article.
Diffusion-weighted magnetic resonance imaging in focal breast lesions: analysis of 78 cases with pathological correlation.
F Fornasa, L Pinali, +2 authors, S Montemezzi.
Radiol Med, 2010 Nov 16; 116(2). PMID: 21076884
Meta-analysis of quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesions.
Xin Chen, Wen-ling Li, +3 authors, Zhi-lan Bai.
BMC Cancer, 2010 Dec 30; 10. PMID: 21189150    Free PMC article.
Improved hardware for higher spatial resolution strain-encoded (SENC) breast MRI for strain measurements.
Ahmed A Harouni, Jakir Hossain, Michael A Jacobs, Nael F Osman.
Acad Radiol, 2011 Mar 29; 18(6). PMID: 21440464    Free PMC article.
Characterization of ductal carcinoma in situ on diffusion weighted breast MRI.
Habib Rahbar, Savannah C Partridge, +4 authors, Constance D Lehman.
Eur Radiol, 2011 May 13; 21(9). PMID: 21562806
Breast MR with special focus on DW-MRI and DCE-MRI.
G Petralia, L Bonello, +2 authors, M Bellomi.
Cancer Imaging, 2011 Jul 21; 11. PMID: 21771711    Free PMC article.
Review.
Usefulness of diffusion-weighted imaging of breast tumors: quantitative and visual assessment.
Kaiji Inoue, Eito Kozawa, +4 authors, Fumiko Kimura.
Jpn J Radiol, 2011 Jul 26; 29(6). PMID: 21786099
Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer.
S Y Choi, Y-W Chang, +3 authors, D Y Seo.
Br J Radiol, 2011 Dec 01; 85(1016). PMID: 22128125    Free PMC article.
Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma.
Katsuhiro Nasu, Yoshifumi Kuroki, Manabu Minami.
Jpn J Radiol, 2011 Dec 17; 30(2). PMID: 22173559
High-resolution diffusion-weighted magnetic resonance imaging in patients with locally advanced breast cancer.
Lisa Singer, Lisa J Wilmes, +7 authors, Nola M Hylton.
Acad Radiol, 2011 Dec 27; 19(5). PMID: 22197382    Free PMC article.
Diffusion tensor magnetic resonance imaging of the normal breast: reproducibility of DTI-derived fractional anisotropy and apparent diffusion coefficient at 3.0 T.
A Tagliafico, G Rescinito, +5 authors, M Calabrese.
Radiol Med, 2012 May 15; 117(6). PMID: 22580812
Apparent diffusion coefficient measurements in the differentiation between benign and malignant lesions: a systematic review.
M A Vermoolen, T C Kwee, R A J Nievelstein.
Insights Imaging, 2012 Jun 15; 3(4). PMID: 22695951    Free PMC article.
Conspicuity of breast lesions at different b values on diffusion-weighted imaging.
Xin Chen, Xi-Jing He, +5 authors, Qian Wu.
BMC Cancer, 2012 Aug 03; 12. PMID: 22853049    Free PMC article.
Molecular imaging of water binding state and diffusion in breast cancer using diffuse optical spectroscopy and diffusion weighted MRI.
So Hyun Chung, Hon Yu, +2 authors, Bruce J Tromberg.
J Biomed Opt, 2012 Aug 17; 17(7). PMID: 22894465    Free PMC article.
Diffusion-weighted magnetic resonance imaging for assessment after neoadjuvant chemotherapy in breast cancer, based on morphological concepts.
Yoriko Murata, Kei Kubota, +9 authors, Yasuhiro Ogawa.
Oncol Lett, 2010 Mar 01; 1(2). PMID: 22966297    Free PMC article.
MR imaging of malignant primary breast lymphoma: including diffusion-weighted imaging, histologic features, and a literature review.
Roka Namoto Matsubayashi, Yuka Inoue, +3 authors, Toru Muranaka.
Jpn J Radiol, 2013 Jul 13; 31(10). PMID: 23846235
Review.
Diffusion-weighted magnetic resonance imaging of breast lesions: the influence of different fat-suppression techniques on quantitative measurements and their reproducibility.
P Mürtz, M Tsesarskiy, +6 authors, H H Schild.
Eur Radiol, 2014 Jun 06; 24(10). PMID: 24898097
Magnetic resonance in the detection of breast cancers of different histological types.
Rebecca M Mayrhofer, Hsiao Piau Ng, Thomas C Putti, Philip W Kuchel.
Magn Reson Insights, 2013 Jan 01; 6. PMID: 25114543    Free PMC article.
Review.
Dynamic properties of water in breast pathology depend on the histological compounds: distinguishing tissue malignancy by water diffusion coefficients.
Rustem F Baikeev, Roman A Gubanov, +3 authors, Timur A Sibgatullin.
BMC Res Notes, 2014 Dec 10; 7. PMID: 25487139    Free PMC article.
Investigation of the optimal b-value to detect breast tumors with diffusion weighted imaging by 1.5-T MRI.
Takayuki Tamura, Shigeru Murakami, +3 authors, Takeshi Kikkawa.
Cancer Imaging, 2015 Jan 23; 14. PMID: 25608450    Free PMC article.
MR mammography using diffusion-weighted imaging in evaluating breast cancer: a correlation with proliferation index.
Cristina Molinari, Paola Clauser, +5 authors, Massimo Bazzocchi.
Radiol Med, 2015 Mar 18; 120(10). PMID: 25776017
Diffusion-weighted imaging of breast tumours at 3 Tesla and 7 Tesla: a comparison.
S Gruber, L Minarikova, +7 authors, W Bogner.
Eur Radiol, 2015 Aug 28; 26(5). PMID: 26310582
Diagnostic performance of ADCs in different ROIs for breast lesions.
Wei Zhang, Guan-Qiao Jin, +6 authors, Wei-Li Huang.
Int J Clin Exp Med, 2015 Nov 10; 8(8). PMID: 26550121    Free PMC article.
Nomogram basing pre-treatment parameters predicting early response for locally advanced rectal cancer with neoadjuvant chemotherapy alone: a subgroup efficacy analysis of FOWARC study.
Jianwei Zhang, Yue Cai, +10 authors, Yanhong Deng.
Oncotarget, 2015 Dec 10; 7(4). PMID: 26646794    Free PMC article.
Diffusion Weighted MR Imaging of Breast and Correlation of Prognostic Factors in Breast Cancer.
İnci Kızıldağ Yırgın, Gözde Arslan, +5 authors, Eyüp Kaya.
Balkan Med J, 2016 Jun 17; 33(3). PMID: 27308074    Free PMC article.
Analysis of factors influencing the degree of detectability on diffusion-weighted MRI and diffusion background signals in patients with invasive breast cancer.
Soo Yeon Hahn, Eun Sook Ko, +3 authors, Eun Young Ko.
Medicine (Baltimore), 2016 Jul 12; 95(27). PMID: 27399100    Free PMC article.
Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers.
Ken Yamaguchi, Takahiko Nakazono, +4 authors, Hiroyuki Irie.
Magn Reson Med Sci, 2016 Nov 18; 16(3). PMID: 27853053    Free PMC article.
Contribution of diffusion weighted MRI to diagnosis and staging in gastric tumors and comparison with multi-detector computed tomography.
Harun Arslan, Mehmet Fatih Özbay, +8 authors, Mehmet Çetin Kotan.
Radiol Oncol, 2017 Mar 08; 51(1). PMID: 28265229    Free PMC article.
Optimization of intra-voxel incoherent motion measurement in diffusion-weighted imaging of breast cancer.
Wenjing Chen, Juan Zhang, +2 authors, Jian-Ming Zhu.
J Appl Clin Med Phys, 2017 Mar 30; 18(3). PMID: 28349630    Free PMC article.
Value of Minimum Apparent Diffusion Coefficient on Magnetic Resonance Imaging as a Biomarker for Predicting Progression of Disease Following Surgery and Radiotherapy in Glial Tumors from a Tertiary Care Center in Northern India.
Pramod Kumar Gupta, Rishi Awasthi, +4 authors, Shaleen Kumar.
J Neurosci Rural Pract, 2017 May 10; 8(2). PMID: 28479790    Free PMC article.
Potential Clinical Applications of 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Mammography in Breast Cancer.
Ihn-Ho Cho, Eun-Jung Kong.
Nucl Med Mol Imaging, 2017 Sep 08; 51(3). PMID: 28878847    Free PMC article.
Review.
Combining multiparametric MRI with receptor information to optimize prediction of pathologic response to neoadjuvant therapy in breast cancer: preliminary results.
Hakmook Kang, Allison Hainline, +8 authors, Thomas E Yankeelov.
J Med Imaging (Bellingham), 2018 Jan 13; 5(1). PMID: 29322067    Free PMC article.
Can apparent diffusion coefficient (ADC) distinguish breast cancer from benign breast findings? A meta-analysis based on 13 847 lesions.
Alexey Surov, Hans Jonas Meyer, Andreas Wienke.
BMC Cancer, 2019 Oct 17; 19(1). PMID: 31615463    Free PMC article.
Nomogram for predicting pathological complete response and tumor downstaging in patients with locally advanced rectal cancer on the basis of a randomized clinical trial.
Jian-Wei Zhang, Yue Cai, +11 authors, Yan-Hong Deng.
Gastroenterol Rep (Oxf), 2020 Jul 16; 8(3). PMID: 32665855    Free PMC article.
Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T(2)-weighted and diffusion-weighted MRI.
Ming Q Huang, Stephen Pickup, +7 authors, Jerry D Glickson.
NMR Biomed, 2008 Nov 07; 21(10). PMID: 18988250    Free PMC article.
Turbo Spin-echo Diffusion-weighted Imaging Compared with Single-shot Echo-planar Diffusion-weighted Imaging: Image Quality and Diagnostic Performance When Differentiating between Ductal Carcinoma in situ and Invasive Ductal Carcinoma.
Naoko Mori, Shunji Mugikura, +4 authors, Kei Takase.
Magn Reson Med Sci, 2020 Mar 10; 20(1). PMID: 32147641    Free PMC article.
Candidate biomarkers of extravascular extracellular space: a direct comparison of apparent diffusion coefficient and dynamic contrast-enhanced MR imaging--derived measurement of the volume of the extravascular extracellular space in glioblastoma multiforme.
S J Mills, C Soh, +4 authors, A Jackson.
AJNR Am J Neuroradiol, 2009 Oct 24; 31(3). PMID: 19850765    Free PMC article.