Journal Article
. 2005 Sep; 11(18):6713-21.
doi: 10.1158/1078-0432.CCR-05-0883.

Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity

Eiji Suzuki 1 Veena Kapoor  Arminder Singh Jassar  Larry R Kaiser  Steven M Albelda  
  • PMID: 16166452
  •     438 citations


Purpose: Myeloid suppressor (Gr-1(+)/CD11b(+)) cells accumulate in the spleens of tumor-bearing mice where they contribute to immunosuppression by inhibiting the function of CD8(+) T cells and by promoting tumor angiogenesis. Elimination of these myeloid suppressor cells may thus significantly improve antitumor responses and enhance effects of cancer immunotherapy, although to date few practical options exist.

Experimental Design: The effect of the chemotherapy drug gemcitabine on the number of (Gr-1(+)/CD11b(+)) cells in the spleens of animals bearing large tumors derived from five cancer lines grown in both C57Bl/6 and BALB/c mice was analyzed. Suppressive activity of splenocytes from gemcitabine-treated and control animals was measured in natural killer (NK) cell lysis and Winn assays. The impact of myeloid suppressor cell activity was determined in an immunogene therapy model using an adenovirus expressing IFN-beta.

Results: This study shows that the chemotherapeutic drug gemcitabine, given at a dose similar to the equivalent dose used in patients, was able to dramatically and specifically reduce the number of myeloid suppressor cells found in the spleens of animals bearing large tumors with no significant reductions in CD4(+) T cells, CD8(+) T cells, NK cells, macrophages, or B cells. The loss of myeloid suppressor cells was accompanied by an increase in the antitumor activity of CD8(+) T cells and activated NK cells. Combining gemcitabine with cytokine immunogene therapy using IFN-beta markedly enhanced antitumor efficacy.

Conclusions: These results suggest that gemcitabine may be a practical strategy for the reduction of myeloid suppressor cells and should be evaluated in conjunction with a variety of immunotherapy approaches.

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G K Chimal-Ramírez, N A Espinoza-Sánchez, E M Fuentes-Pananá.
J Oncol, 2013 Apr 12; 2013. PMID: 23577028    Free PMC article.
Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma.
Tomar Ghansah, Nasreen Vohra, +5 authors, Shari Pilon-Thomas.
Cancer Immunol Immunother, 2013 Apr 23; 62(6). PMID: 23604104    Free PMC article.
Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis.
Dominic E Sanford, Brian A Belt, +12 authors, David C Linehan.
Clin Cancer Res, 2013 May 09; 19(13). PMID: 23653148    Free PMC article.
Highly Cited.
The impact of the myeloid response to radiation therapy.
Michael J Gough, Kristina Young, Marka Crittenden.
Clin Dev Immunol, 2013 May 09; 2013. PMID: 23653658    Free PMC article.
Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer.
Xiaolin Hu, Kankana Bardhan, +7 authors, Kebin Liu.
J Biol Chem, 2013 May 17; 288(26). PMID: 23677993    Free PMC article.
Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis.
Yingying Lin, Chongyang Wei, +3 authors, Fang Guo.
Cancer Sci, 2013 May 23; 104(9). PMID: 23691974    Free PMC article.
T Cell Stimulatory Effects of Korean Red Ginseng through Modulation of Myeloid-Derived Suppressor Cells.
Chanoh Jeon, Soowon Kang, +3 authors, Hyeyoung Min.
J Ginseng Res, 2011 Nov 01; 35(4). PMID: 23717093    Free PMC article.
Potential therapeutic anti-tumor effect of a Salmonella-based vaccine.
Sun-Young Chang, Yeon-Jeong Kim, Hyun-Jeong Ko.
Hum Vaccin Immunother, 2013 Jun 05; 9(8). PMID: 23733040    Free PMC article.
Myeloid derived suppressor cells: Targets for therapy.
Todd J Waldron, Jon G Quatromoni, +2 authors, Anil K Rustgi.
Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734336    Free PMC article.
Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells.
Hélène Bugaut, Mélanie Bruchard, +10 authors, Grégoire Mignot.
PLoS One, 2013 Jun 14; 8(6). PMID: 23762310    Free PMC article.
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer.
L Bracci, G Schiavoni, A Sistigu, F Belardelli.
Cell Death Differ, 2013 Jun 22; 21(1). PMID: 23787994    Free PMC article.
Highly Cited. Review.
Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation.
K Kono, K Mimura, R Kiessling.
Cell Death Dis, 2013 Jun 22; 4. PMID: 23788045    Free PMC article.
Changes in the immune cell population and cell proliferation in peripheral blood after gemcitabine-based chemotherapy for pancreatic cancer.
Y Homma, K Taniguchi, +6 authors, I Endo.
Clin Transl Oncol, 2013 Jul 19; 16(3). PMID: 23860726
New insights into the role of the immune microenvironment in breast carcinoma.
Luis de la Cruz-Merino, Antonio Barco-Sánchez, +12 authors, José Ibáñez Martínez.
Clin Dev Immunol, 2013 Jul 19; 2013. PMID: 23861693    Free PMC article.
Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target.
Elizabeth A Grimm, Andrew G Sikora, Suhendan Ekmekcioglu.
Clin Cancer Res, 2013 Jul 23; 19(20). PMID: 23868870    Free PMC article.
Current trends of anticancer immunochemotherapy.
Erika Vacchelli, Nicole Prada, Oliver Kepp, Lorenzo Galluzzi.
Oncoimmunology, 2013 Jul 31; 2(6). PMID: 23894726    Free PMC article.
Checkpoint modulation in melanoma: an update on ipilimumab and future directions.
David B Page, Michael A Postow, Margaret K Callahan, Jedd D Wolchok.
Curr Oncol Rep, 2013 Aug 13; 15(5). PMID: 23933888    Free PMC article.
The peripheral myeloid expansion driven by murine cancer progression is reversed by radiation therapy of the tumor.
Marka R Crittenden, Talicia Savage, +7 authors, Michael J Gough.
PLoS One, 2013 Aug 13; 8(7). PMID: 23936036    Free PMC article.
History of myeloid-derived suppressor cells.
James E Talmadge, Dmitry I Gabrilovich.
Nat Rev Cancer, 2013 Sep 26; 13(10). PMID: 24060865    Free PMC article.
Highly Cited. Review.
Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways.
Anandi Sawant, Cara C Schafer, +9 authors, Jessy S Deshane.
Cancer Res, 2013 Oct 03; 73(22). PMID: 24085788    Free PMC article.
Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis.
Jeremy D Waight, Colleen Netherby, +8 authors, Scott I Abrams.
J Clin Invest, 2013 Oct 05; 123(10). PMID: 24091328    Free PMC article.
Highly Cited.
Schedule-dependent therapeutic efficacy of L19mTNF-α and melphalan combined with gemcitabine.
Lorenzo Mortara, Paola Orecchia, +3 authors, Enrica Balza.
Cancer Med, 2013 Oct 25; 2(4). PMID: 24156020    Free PMC article.
The significant increase and dynamic changes of the myeloid-derived suppressor cells percentage with chemotherapy in advanced NSCLC patients.
S Wang, Y Fu, +5 authors, X Wu.
Clin Transl Oncol, 2013 Nov 07; 16(7). PMID: 24193866
Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer.
Darya Alizadeh, Malika Trad, +5 authors, Nicolas Larmonier.
Cancer Res, 2013 Nov 08; 74(1). PMID: 24197130    Free PMC article.
Highly Cited.
Antitumor effects of anti-CD40/CpG immunotherapy combined with gemcitabine or 5-fluorouracil chemotherapy in the B16 melanoma model.
Xiaoyi Qu, Mildred A R Felder, +2 authors, Alexander L Rakhmilevich.
Int Immunopharmacol, 2013 Nov 10; 17(4). PMID: 24201083    Free PMC article.
Immune-checkpoint blockade and active immunotherapy for glioma.
Brian J Ahn, Ian F Pollack, Hideho Okada.
Cancers (Basel), 2013 Nov 10; 5(4). PMID: 24202450    Free PMC article.
Immune modulation by chemotherapy or immunotherapy to enhance cancer vaccines.
Genevieve M Weir, Robert S Liwski, Marc Mansour.
Cancers (Basel), 2011 Jan 01; 3(3). PMID: 24212948    Free PMC article.
Immunotherapy and immune evasion in prostate cancer.
Archana Thakur, Ulka Vaishampayan, Lawrence G Lum.
Cancers (Basel), 2013 Nov 13; 5(2). PMID: 24216992    Free PMC article.
Hampering immune suppressors: therapeutic targeting of myeloid-derived suppressor cells in cancer.
Sabrin Husein Albeituni, Chuanlin Ding, Jun Yan.
Cancer J, 2013 Nov 26; 19(6). PMID: 24270348    Free PMC article.
Dendritic cell derived cytokines in human natural killer cell differentiation and activation.
Obinna Chijioke, Christian Münz.
Front Immunol, 2013 Nov 26; 4. PMID: 24273539    Free PMC article.
Beneficial and Detrimental Roles of NLRs in Carcinogenesis.
Ann M Janowski, Ryan Kolb, Weizhou Zhang, Fayyaz S Sutterwala.
Front Immunol, 2013 Nov 26; 4. PMID: 24273542    Free PMC article.
Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms.
S A Gujar, D Clements, +3 authors, P W K Lee.
Br J Cancer, 2013 Nov 28; 110(1). PMID: 24281006    Free PMC article.
Immunological Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapy.
Joshua P Landreneau, Michael R Shurin, +3 authors, Galina V Shurin.
Cancer Microenviron, 2013 Dec 03; 8(2). PMID: 24293116    Free PMC article.
Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors.
Chao-Yi Wu, Li-Hua Yang, +9 authors, T-C Wu.
Clin Cancer Res, 2013 Dec 05; 20(3). PMID: 24300786    Free PMC article.
Enhancing immunotherapy using chemotherapy and radiation to modify the tumor microenvironment.
Michael H Kershaw, Christel Devaud, +2 authors, Phillip K Darcy.
Oncoimmunology, 2013 Dec 12; 2(9). PMID: 24327938    Free PMC article.
Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma.
Raffaella Iannone, Lucio Miele, +2 authors, Silvana Morello.
Neoplasia, 2014 Jan 10; 15(12). PMID: 24403862    Free PMC article.
Integrating new discoveries into the "vicious cycle" paradigm of prostate to bone metastases.
Leah M Cook, Gemma Shay, +2 authors, Conor C Lynch.
Cancer Metastasis Rev, 2014 Jan 15; 33(2-3). PMID: 24414228    Free PMC article.
Origin and pharmacological modulation of tumor-associated regulatory dendritic cells.
Hua Zhong, Dmitriy W Gutkin, +4 authors, Galina V Shurin.
Int J Cancer, 2014 Jan 21; 134(11). PMID: 24443321    Free PMC article.
Immunotherapy for solid tumors--a review for surgeons.
Abdul Saied, Venu G Pillarisetty, Steven C Katz.
J Surg Res, 2014 Feb 04; 187(2). PMID: 24485876    Free PMC article.
Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer.
Sumiyuki Nishida, Shigeo Koido, +29 authors, Haruo Sugiyama.
J Immunother, 2014 Feb 11; 37(2). PMID: 24509173    Free PMC article.
Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors.
Seiko Toraya-Brown, Mee Rie Sheen, +7 authors, Steven Fiering.
Nanomedicine, 2014 Feb 26; 10(6). PMID: 24566274    Free PMC article.
What is the role of chemotherapy in the treatment of melanoma?
Ahmed I Megahed, Henry B Koon.
Curr Treat Options Oncol, 2014 Mar 07; 15(2). PMID: 24599525
Boosting the MHC Class II-Restricted Tumor Antigen Presentation to CD4+ T Helper Cells: A Critical Issue for Triggering Protective Immunity and Re-Orienting the Tumor Microenvironment Toward an Anti-Tumor State.
Roberto S Accolla, Letizia Lombardo, +3 authors, Giovanna Tosi.
Front Oncol, 2014 Mar 07; 4. PMID: 24600588    Free PMC article.
Chemotherapeutic targeting of myeloid-derived suppressor cells.
Darya Alizadeh, Emmanuel Katsanis, Nicolas Larmonier.
Oncoimmunology, 2014 Mar 22; 3(1). PMID: 24653963    Free PMC article.
Gr-1+CD11b+ cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation.
Tao Liu, Congying Xie, +7 authors, Gang Wu.
Sci Rep, 2014 Apr 30; 4. PMID: 24776637    Free PMC article.
Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis.
Zhi-Chun Ding, Xiaoyun Lu, +11 authors, Gang Zhou.
Cancer Res, 2014 May 02; 74(13). PMID: 24780756    Free PMC article.
Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses.
Shashi A Gujar, Derek Clements, Patrick Wk Lee.
Oncoimmunology, 2014 May 08; 3(1). PMID: 24804161    Free PMC article.
Myeloid derived suppressor cells - a new therapeutic target in the treatment of cancer.
Robert Wesolowski, Joseph Markowitz, William E Carson.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829747    Free PMC article.
Highly Cited. Review.
Very small size proteoliposomes abrogate cross-presentation of tumor antigens by myeloid-derived suppressor cells and induce their differentiation to dendritic cells.
Audry Fernández, Liliana Oliver, +4 authors, Circe Mesa.
J Immunother Cancer, 2014 May 16; 2. PMID: 24829762    Free PMC article.
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
Yoshitaro Shindo, Shoichi Hazama, +11 authors, Masaaki Oka.
J Transl Med, 2014 Jun 21; 12. PMID: 24947606    Free PMC article.
Chemotherapy and Oncolytic Virotherapy: Advanced Tactics in the War against Cancer.
Andrew Nguyen, Louisa Ho, Yonghong Wan.
Front Oncol, 2014 Jun 27; 4. PMID: 24967214    Free PMC article.
Myeloid-derived cells are key targets of tumor immunotherapy.
José Medina-Echeverz, Fernando Aranda, Pedro Berraondo.
Oncoimmunology, 2014 Jul 23; 3. PMID: 25050208    Free PMC article.
Trial Watch: Adoptive cell transfer for anticancer immunotherapy.
Fernando Aranda, Erika Vacchelli, +8 authors, Lorenzo Galluzzi.
Oncoimmunology, 2014 Jul 23; 3. PMID: 25050207    Free PMC article.
Dissecting the role of bone marrow stromal cells on bone metastases.
Denise Buenrostro, Serk In Park, Julie A Sterling.
Biomed Res Int, 2014 Jul 24; 2014. PMID: 25054153    Free PMC article.
MDSCs mediate angiogenesis and predispose canine mammary tumor cells for metastasis via IL-28/IL-28RA (IFN-λ) signaling.
Joanna Mucha, Kinga Majchrzak, +2 authors, Magdalena Król.
PLoS One, 2014 Jul 31; 9(7). PMID: 25075523    Free PMC article.
Oncolytic viruses as anticancer vaccines.
Norman Woller, Engin Gürlevik, +2 authors, Florian Kühnel.
Front Oncol, 2014 Aug 08; 4. PMID: 25101244    Free PMC article.
Cancer immunotherapy in clinical practice -- the past, present, and future.
Gaurav Goel, Weijing Sun.
Chin J Cancer, 2014 Sep 06; 33(9). PMID: 25189717    Free PMC article.
Immunotherapy advances for glioblastoma.
David A Reardon, Gordon Freeman, +7 authors, Glenn Dranoff.
Neuro Oncol, 2014 Sep 06; 16(11). PMID: 25190673    Free PMC article.
Highly Cited. Review.
IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
Miao-Fen Chen, Feng-Che Kuan, +5 authors, Kuan-Der Lee.
Oncotarget, 2014 Sep 23; 5(18). PMID: 25238263    Free PMC article.
Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state.
Miki Tongu, Nanae Harashima, +2 authors, Mamoru Harada.
Cancer Sci, 2014 Nov 05; 106(1). PMID: 25363339    Free PMC article.
A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients.
Eleni-Kyriaki Vetsika, Filippos Koinis, +6 authors, Athanasios Kotsakis.
J Immunol Res, 2014 Dec 02; 2014. PMID: 25436215    Free PMC article.
Peptide vaccines for the treatment of glioblastoma.
Adam M Swartz, Kristen A Batich, Peter E Fecci, John H Sampson.
J Neurooncol, 2014 Dec 11; 123(3). PMID: 25491947
Classification of current anticancer immunotherapies.
Lorenzo Galluzzi, Erika Vacchelli, +85 authors, Guido Kroemer.
Oncotarget, 2014 Dec 30; 5(24). PMID: 25537519    Free PMC article.
Highly Cited. Review.
Microenvironmental regulation of therapeutic response in cancer.
Florian Klemm, Johanna A Joyce.
Trends Cell Biol, 2014 Dec 30; 25(4). PMID: 25540894    Free PMC article.
Highly Cited. Review.
Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance.
Irina Kareva, David J Waxman, Giannoula Lakka Klement.
Cancer Lett, 2014 Dec 30; 358(2). PMID: 25541061    Free PMC article.
Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.
Xiaoyun Lu, Zhi-Chun Ding, +8 authors, Gang Zhou.
J Immunol, 2015 Jan 07; 194(4). PMID: 25560408    Free PMC article.
Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer.
Shuhei Mayanagi, Minoru Kitago, +13 authors, Yuko Kitagawa.
Cancer Sci, 2015 Jan 24; 106(4). PMID: 25614082    Free PMC article.
Vaccines versus immunotherapy: overview of approaches in deciding between options.
Angus G Dalgleish.
Hum Vaccin Immunother, 2015 Jan 28; 10(11). PMID: 25625932    Free PMC article.
Nivolumab in NSCLC: latest evidence and clinical potential.
Raghav Sundar, Byoung-Chul Cho, Julie R Brahmer, Ross A Soo.
Ther Adv Med Oncol, 2015 Mar 11; 7(2). PMID: 25755681    Free PMC article.
Highly Cited. Review.
Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium.
Hang Wang, Tsung-Lin Li, +3 authors, Chang-Jer Wu.
Oncotarget, 2015 Mar 24; 6(10). PMID: 25797259    Free PMC article.
Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer.
Inès Dufait, Julia Katharina Schwarze, +5 authors, Karine Breckpot.
Oncotarget, 2015 Apr 15; 6(14). PMID: 25869209    Free PMC article.
Cancer vaccines.
Lisa H Butterfield.
BMJ, 2015 Apr 24; 350. PMID: 25904595    Free PMC article.
Highly Cited. Review.
Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells.
Ji Sung Kim, Yong Guk Kim, +4 authors, Sang-Bae Han.
Immune Netw, 2015 Apr 30; 15(2). PMID: 25922594    Free PMC article.
The interplay of immunotherapy and chemotherapy: harnessing potential synergies.
Leisha A Emens, Gary Middleton.
Cancer Immunol Res, 2015 May 06; 3(5). PMID: 25941355    Free PMC article.
Highly Cited. Review.
Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy.
Oana Draghiciu, Joyce Lubbers, Hans W Nijman, Toos Daemen.
Oncoimmunology, 2015 May 08; 4(1). PMID: 25949858    Free PMC article.
Highly Cited. Review.
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.
Oana Draghiciu, Hans W Nijman, +2 authors, Toos Daemen.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949902    Free PMC article.
Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma.
Yusuke Sato, Kanako Shimizu, +6 authors, Shin-Ichiro Fujii.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949922    Free PMC article.
Bone-immune cell crosstalk: bone diseases.
Giorgio Mori, Patrizia D'Amelio, Roberta Faccio, Giacomina Brunetti.
J Immunol Res, 2015 May 23; 2015. PMID: 26000310    Free PMC article.
Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer.
Hiroshi Katoh, Masahiko Watanabe.
Mediators Inflamm, 2015 Jun 17; 2015. PMID: 26078490    Free PMC article.
Switching off malignant pleural effusion formation-fantasy or future?
Magda Spella, Anastasios D Giannou, Georgios T Stathopoulos.
J Thorac Dis, 2015 Jul 08; 7(6). PMID: 26150914    Free PMC article.
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected.
Douglas Marvel, Dmitry I Gabrilovich.
J Clin Invest, 2015 Jul 15; 125(9). PMID: 26168215    Free PMC article.
Highly Cited. Review.
Progression of Large Lymphoma Is Significantly Impeded with a Combination of Gemcitabine Chemotherapy and Dendritic Cells Intra-Tumor Vaccination.
Xue-Jun Zhu, Zhong-Fa Yang, +8 authors, Li-Xin Wang.
PLoS One, 2015 Jul 17; 10(7). PMID: 26181041    Free PMC article.
Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension.
Kandarp H Shah, Peng Shi, +7 authors, Xiao Z Shen.
Circ Res, 2015 Aug 22; 117(10). PMID: 26294657    Free PMC article.
Relevance of tumor-infiltrating lymphocytes in breast cancer.
Sathana Dushyanthen, Paul A Beavis, +5 authors, Sherene Loi.
BMC Med, 2015 Aug 25; 13. PMID: 26300242    Free PMC article.
Highly Cited. Review.
Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model.
Claudia Sorrentino, Lucio Miele, +2 authors, Silvana Morello.
Oncotarget, 2015 Sep 01; 6(29). PMID: 26317647    Free PMC article.
Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages.
Stefano Ugel, Francesco De Sanctis, Susanna Mandruzzato, Vincenzo Bronte.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325033    Free PMC article.
Highly Cited. Review.
A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer.
Eveline M Dijkgraaf, Saskia J A M Santegoets, +11 authors, Sjoerd H van der Burg.
Oncotarget, 2015 Sep 04; 6(31). PMID: 26334096    Free PMC article.
Tolerance and immune suppression in the tumor microenvironment.
Suzanne Ostrand-Rosenberg.
Cell Immunol, 2015 Oct 06; 299. PMID: 26435343    Free PMC article.
Modulation of APC Function and Anti-Tumor Immunity by Anti-Cancer Drugs.
Kea Martin, Jens Schreiner, Alfred Zippelius.
Front Immunol, 2015 Oct 21; 6. PMID: 26483791    Free PMC article.
Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy.
Kelly Kersten, Camilla Salvagno, Karin E de Visser.
Front Immunol, 2015 Oct 27; 6. PMID: 26500653    Free PMC article.
Paving the Road to Tumor Development and Spreading: Myeloid-Derived Suppressor Cells are Ruling the Fate.
Yaron Meirow, Julia Kanterman, Michal Baniyash.
Front Immunol, 2015 Nov 04; 6. PMID: 26528286    Free PMC article.
Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity.
Bing Liu, Liyan Qu, Shigui Yan.
Cancer Cell Int, 2015 Nov 10; 15. PMID: 26549987    Free PMC article.
Highly Cited. Review.
Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis.
Bin Shao, Xiawei Wei, +17 authors, Yuquan Wei.
Sci Rep, 2015 Nov 13; 5. PMID: 26561336    Free PMC article.
Cisplatin selectively downregulated the frequency and immunoinhibitory function of myeloid-derived suppressor cells in a murine B16 melanoma model.
Xiang Huang, Shiyun Cui, Yongqian Shu.
Immunol Res, 2015 Nov 23; 64(1). PMID: 26590944
The immunobiology of myeloid-derived suppressor cells in cancer.
Morteza Motallebnezhad, Farhad Jadidi-Niaragh, +3 authors, Mehdi Yousefi.
Tumour Biol, 2015 Nov 28; 37(2). PMID: 26611648
A HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model.
Yuh-Pyng Sher, Su-I Lin, +6 authors, Shih-Jen Liu.
Oncotarget, 2015 Dec 02; 7(1). PMID: 26621839    Free PMC article.
Targeting the microenvironment of pancreatic cancer: overcoming treatment barriers and improving local immune responses.
J Strauss, C Alewine, W D Figg, A Duffy.
Clin Transl Oncol, 2015 Dec 15; 18(7). PMID: 26661112    Free PMC article.
The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer.
Mahiru Kawano, Seiji Mabuchi, +10 authors, Tadashi Kimura.
Sci Rep, 2015 Dec 17; 5. PMID: 26666576    Free PMC article.
MDSC-decreasing chemotherapy increases the efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma and pancreatic cancer.
Zibing Wang, Yuqing Liu, +2 authors, Quanli Gao.
Oncotarget, 2015 Dec 31; 7(4). PMID: 26716894    Free PMC article.
IL-15/sIL-15Rα gene transfer suppresses Lewis lung cancer growth in the lungs, liver and kidneys.
H Sun, D Liu.
Cancer Gene Ther, 2016 Jan 09; 23(2-3). PMID: 26742578
Adapting conventional cancer treatment for immunotherapy.
Jian Qiao, Zhida Liu, Yang-Xin Fu.
J Mol Med (Berl), 2016 Feb 26; 94(5). PMID: 26910191
Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model.
Nadia M Luheshi, Jane Coates-Ulrichsen, +8 authors, Robert W Wilkinson.
Oncotarget, 2016 Feb 27; 7(14). PMID: 26918344    Free PMC article.
Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma.
Gary Middleton, William Greenhalf, +5 authors, John P Neoptolemos.
Br J Cancer, 2016 Mar 05; 114(5). PMID: 26931369    Free PMC article.
Vaccines for established cancer: overcoming the challenges posed by immune evasion.
Sjoerd H van der Burg, Ramon Arens, +2 authors, Cornelis J M Melief.
Nat Rev Cancer, 2016 Mar 12; 16(4). PMID: 26965076
Highly Cited. Review.
Myeloid cell signatures in tumor microenvironment predicts therapeutic response in cancer.
Bhagelu R Achyut, Ali S Arbab.
Onco Targets Ther, 2016 Apr 05; 9. PMID: 27042097    Free PMC article.
Cancer-Associated Myeloid Regulatory Cells.
Yannick De Vlaeminck, Anna González-Rascón, Cleo Goyvaerts, Karine Breckpot.
Front Immunol, 2016 Apr 12; 7. PMID: 27065074    Free PMC article.
Myeloid-Derived Suppressor Cells in Bacterial Infections.
Michael Ost, Anurag Singh, +3 authors, Dominik Hartl.
Front Cell Infect Microbiol, 2016 Apr 12; 6. PMID: 27066459    Free PMC article.
Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis.
Charis Kalogirou, Andrey Svistunov, +4 authors, Arkadius Kocot.
Mol Clin Oncol, 2016 Apr 14; 4(4). PMID: 27073682    Free PMC article.
Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer.
Mikio Kajihara, Kazuki Takakura, +6 authors, Shigeo Koido.
World J Gastroenterol, 2016 May 18; 22(18). PMID: 27182156    Free PMC article.
Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignancies.
Chuang Sun, Gianpietro Dotti, Barbara Savoldo.
Blood, 2016 May 22; 127(26). PMID: 27207792    Free PMC article.
Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists.
Soraya Zorro Manrique, Ana L Dominguez, +7 authors, Peter A Cohen.
Oncotarget, 2016 Jun 25; 7(28). PMID: 27341020    Free PMC article.
Nivolumab in Combination With Platinum-Based Doublet Chemotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer.
Naiyer A Rizvi, Matthew D Hellmann, +13 authors, Scott Antonia.
J Clin Oncol, 2016 Jun 30; 34(25). PMID: 27354481    Free PMC article.
Highly Cited.
Gemcitabine Activates Natural Killer Cells to Attenuate Pancreatic Cancer Recurrence.
David W Dawson, Martin E Fernandez-Zapico.
Gastroenterology, 2016 Jul 05; 151(2). PMID: 27374366    Free PMC article.
Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin.
Junmin Zhou, Sarah S Donatelli, +6 authors, Julie Y Djeu.
Sci Rep, 2016 Jul 14; 6. PMID: 27405665    Free PMC article.
Murine mesothelioma induces locally-proliferating IL-10(+)TNF-α(+)CD206(-)CX3CR1(+) M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy.
Connie Jackaman, Teong L Yeoh, +2 authors, Delia J Nelson.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471652    Free PMC article.
Harnessing immunosurveillance: current developments and future directions in cancer immunotherapy.
Maureen L Drakes, Patrick J Stiff.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27471706    Free PMC article.
Emerging role of Natural killer cells in oncolytic virotherapy.
Rauf Bhat, Jean Rommelaere.
Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471713    Free PMC article.
Immunology Comes Full Circle in Melanoma While Specific Immunity Is Unleashed to Eliminate Metastatic Disease, Inflammatory Products of Innate Immunity Promote Resistance.
Elizabeth A Grimm.
Crit Rev Oncog, 2016 Aug 03; 21(1-2). PMID: 27481002    Free PMC article.
Suppressive role of myeloid-derived suppressor cells (MDSCs) in the microenvironment of breast cancer and targeted immunotherapies.
Dawei Shou, Liang Wen, +3 authors, Weihua Gong.
Oncotarget, 2016 Aug 20; 7(39). PMID: 27542274    Free PMC article.
Fatal attraction: TICs and MDSCs.
Thomas Welte, Jeffrey M Rosen, Xiang H-F Zhang.
Cell Cycle, 2016 Oct 18; 15(19). PMID: 27574951    Free PMC article.
Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice.
Ava Vila-Leahey, Sharon A Oldford, +3 authors, Jean S Marshall.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622015    Free PMC article.
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Juan C Mira, Lori F Gentile, +5 authors, Lyle L Moldawer.
Crit Care Med, 2016 Sep 16; 45(2). PMID: 27632674    Free PMC article.
Highly Cited.
BPTF Depletion Enhances T-cell-Mediated Antitumor Immunity.
Kimberly Mayes, Suehyb G Alkhatib, +8 authors, Joseph W Landry.
Cancer Res, 2016 Nov 03; 76(21). PMID: 27651309    Free PMC article.
The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma.
Joo Kyung Park, Yejin Kim, +6 authors, Jae Seung Kang.
Oncotarget, 2016 Sep 23; 7(46). PMID: 27655706    Free PMC article.
Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade.
Seth Levy, Joseph M Feduska, +3 authors, Selvarangan Ponnazhagan.
Bone, 2016 Oct 25; 93. PMID: 27664567    Free PMC article.
Chemo-immunotherapy mediates durable cure of orthotopic KrasG12D/p53-/- pancreatic ductal adenocarcinoma.
Vanaja Konduri, Dali Li, +8 authors, William K Decker.
Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757308    Free PMC article.
Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy.
Neha Kamran, Mayuri Chandran, Pedro R Lowenstein, Maria G Castro.
Clin Immunol, 2016 Nov 04; 189. PMID: 27777083    Free PMC article.
The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression.
Viktor Umansky, Carolin Blattner, Christoffer Gebhardt, Jochen Utikal.
Vaccines (Basel), 2016 Nov 10; 4(4). PMID: 27827871    Free PMC article.
Highly Cited. Review.
Targeting Immune Regulatory Networks to Counteract Immune Suppression in Cancer.
Chiara Camisaschi, Viviana Vallacchi, +10 authors, Veronica Huber.
Vaccines (Basel), 2016 Nov 10; 4(4). PMID: 27827921    Free PMC article.
Systemic, perioperative management of muscle-invasive bladder cancer and future horizons.
Samuel A Funt, Jonathan E Rosenberg.
Nat Rev Clin Oncol, 2016 Nov 23; 14(4). PMID: 27874062    Free PMC article.
Pro-Tumoral Inflammatory Myeloid Cells as Emerging Therapeutic Targets.
Gabor J Szebeni, Csaba Vizler, +2 authors, Laszlo G Puskas.
Int J Mol Sci, 2016 Nov 26; 17(11). PMID: 27886105    Free PMC article.
IL-17A produced by peritoneal macrophages promote the accumulation and function of granulocytic myeloid-derived suppressor cells in the development of colitis-associated cancer.
Yue Zhang, Juan Wang, +6 authors, Shengjun Wang.
Tumour Biol, 2016 Dec 03;. PMID: 27909978
Immunostimulatory Effects of Melphalan and Usefulness in Adoptive Cell Therapy with Antitumor CD4+ T Cells.
Michal Kuczma, Zhi-Chun Ding, Gang Zhou.
Crit Rev Immunol, 2016 Dec 03; 36(2). PMID: 27910767    Free PMC article.
Myeloid-derived suppressor cells and their role in pancreatic cancer.
M Pergamo, G Miller.
Cancer Gene Ther, 2016 Dec 03; 24(3). PMID: 27910857
IL-17A weakens the antitumor immuity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice.
Juan Wang, Yue Zhang, +8 authors, Shengjun Wang.
Oncotarget, 2016 Dec 22; 8(3). PMID: 28002798    Free PMC article.
The Role of Myeloid-Derived Suppressor Cells in Viral Infection.
Megan A O'Connor, Jessica L Rastad, William R Green.
Viral Immunol, 2017 Jan 05; 30(2). PMID: 28051364    Free PMC article.
Myeloid-Derived Suppressor Cells.
Dmitry I Gabrilovich.
Cancer Immunol Res, 2017 Jan 06; 5(1). PMID: 28052991    Free PMC article.
Highly Cited. Review.
GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro.
Tessa Gargett, Susan N Christo, +4 authors, Michael P Brown.
Clin Transl Immunology, 2017 Jan 17; 5(12). PMID: 28090321    Free PMC article.
Clinical and Immune Effects of Lenalidomide in Combination with Gemcitabine in Patients with Advanced Pancreatic Cancer.
Gustav J Ullenhag, Fariba Mozaffari, +2 authors, Maria Liljefors.
PLoS One, 2017 Jan 19; 12(1). PMID: 28099502    Free PMC article.
Immunosuppressive myeloid-derived suppressor cells are increased in splenocytes from cancer patients.
Kimberly R Jordan, Puja Kapoor, +4 authors, Martin D McCarter.
Cancer Immunol Immunother, 2017 Jan 22; 66(4). PMID: 28108766    Free PMC article.
Pediatric hepatocellular carcinoma: challenges and solutions.
Irene Schmid, Dietrich von Schweinitz.
J Hepatocell Carcinoma, 2017 Feb 02; 4. PMID: 28144610    Free PMC article.
Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy.
Paul M Tyler, Mariah M Servos, +6 authors, Stephanie K Dougan.
Mol Cancer Ther, 2017 Feb 06; 16(3). PMID: 28148714    Free PMC article.
Tumor regulation of the tissue environment in the liver.
Tobias Eggert, Tim F Greten.
Pharmacol Ther, 2017 Feb 09; 173. PMID: 28167218    Free PMC article.
The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.
Andrew M K Law, Elgene Lim, Christopher J Ormandy, David Gallego-Ortega.
Endocr Relat Cancer, 2017 Feb 15; 24(4). PMID: 28193698    Free PMC article.
Immune modulation by dendritic-cell-based cancer vaccines.
Chaitanya Kumar, Sakshi Kohli, +4 authors, Bandana Sharan.
J Biosci, 2017 Feb 24; 42(1). PMID: 28229976
Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase.
Todd A Aguilera, Amato J Giaccia.
Clin Cancer Res, 2017 Mar 16; 23(12). PMID: 28289089    Free PMC article.
Arginine Is a Critical Substrate for the Pathogenesis of Pseudomonas aeruginosa in Burn Wound Infections.
Jake Everett, Keith Turner, +3 authors, Kendra Rumbaugh.
mBio, 2017 Mar 16; 8(2). PMID: 28292986    Free PMC article.
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Colleen S Netherby, Michelle N Messmer, +6 authors, Scott I Abrams.
J Immunol, 2017 Mar 31; 198(10). PMID: 28356386    Free PMC article.
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation.
Jonathan E Schoenhals, Steven N Seyedin, +8 authors, James W Welsh.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529897    Free PMC article.
Efficacy of vaccination with tumor-exosome loaded dendritic cells combined with cytotoxic drug treatment in pancreatic cancer.
Li Xiao, Ulrike Erb, +2 authors, Margot Zöller.
Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680753    Free PMC article.
Contrasting effects of cyclophosphamide on anti-CTL-associated protein 4 blockade therapy in two mouse tumor models.
Yuichi Iida, Nanae Harashima, +3 authors, Mamoru Harada.
Cancer Sci, 2017 Aug 09; 108(10). PMID: 28787548    Free PMC article.
Conditioning neoadjuvant therapies for improved immunotherapy of cancer.
Zachary Benson, Saeed H Manjili, +4 authors, Masoud H Manjili.
Biochem Pharmacol, 2017 Aug 15; 145. PMID: 28803721    Free PMC article.
Chemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells.
Zibing Wang, Brian Till, Quanli Gao.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811975    Free PMC article.
The potential and promise of IL-15 in immuno-oncogenic therapies.
Tanya O Robinson, Kimberly S Schluns.
Immunol Lett, 2017 Aug 22; 190. PMID: 28823521    Free PMC article.
Highly Cited. Review.
Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.
Alejandro Jiménez-Sánchez, Danish Memon, +16 authors, Martin L Miller.
Cell, 2017 Aug 26; 170(5). PMID: 28841418    Free PMC article.
Highly Cited.
Cancer vaccines: Enhanced immunogenic modulation through therapeutic combinations.
Margaret E Gatti-Mays, Jason M Redman, Julie M Collins, Marijo Bilusic.
Hum Vaccin Immunother, 2017 Sep 01; 13(11). PMID: 28857666    Free PMC article.
Clinical and biological effects of tumor-associated lymphocytes in the presence or absence of chemotherapy for malignant ascites in ovarian cancer patients.
Weiwei Zhang, Kejun Liu, +4 authors, Weijiang Liang.
Oncol Lett, 2017 Sep 21; 14(3). PMID: 28927091    Free PMC article.
Nanomaterials for cancer immunotherapy.
Wantong Song, Sara N Musetti, Leaf Huang.
Biomaterials, 2017 Sep 30; 148. PMID: 28961532    Free PMC article.
Immunological effects of everolimus in patients with metastatic renal cell cancer.
Charlotte M Huijts, Saskia J Santegoets, +3 authors, Hans J van der Vliet.
Int J Immunopathol Pharmacol, 2017 Oct 11; 30(4). PMID: 28988508    Free PMC article.
Immune recognition of irradiated cancer cells.
Erik Wennerberg, Claire Vanpouille-Box, +3 authors, Lorenzo Galluzzi.
Immunol Rev, 2017 Oct 14; 280(1). PMID: 29027232    Free PMC article.
A Combination of Immune Checkpoint Inhibition with Metronomic Chemotherapy as a Way of Targeting Therapy-Resistant Cancer Cells.
Irina Kareva.
Int J Mol Sci, 2017 Oct 14; 18(10). PMID: 29027915    Free PMC article.
A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice.
Wayne J Aston, Danika E Hope, +3 authors, W Joost Lesterhuis.
BMC Cancer, 2017 Oct 19; 17(1). PMID: 29037232    Free PMC article.
Calreticulin Fragment 39-272 Promotes B16 Melanoma Malignancy through Myeloid-Derived Suppressor Cells In Vivo.
Xiao-Yan He, Fang-Yuan Gong, +3 authors, Xiao-Ming Gao.
Front Immunol, 2017 Oct 28; 8. PMID: 29075268    Free PMC article.
Combining DNA damaging therapeutics with immunotherapy: more haste, less speed.
Jessica S Brown, Raghav Sundar, Juanita Lopez.
Br J Cancer, 2017 Nov 11; 118(3). PMID: 29123260    Free PMC article.
Highly Cited. Review.
Excellent response to chemotherapy post immunotherapy.
Ashish D Dwary, Samip Master, +8 authors, Kavitha Beedupalli.
Oncotarget, 2017 Dec 07; 8(53). PMID: 29207685    Free PMC article.
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment.
Susanne M Steggerda, Mark K Bennett, +18 authors, Matthew I Gross.
J Immunother Cancer, 2017 Dec 20; 5(1). PMID: 29254508    Free PMC article.
Highly Cited.
A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells.
Haoran Liu, Junhua Mai, +15 authors, Haifa Shen.
Theranostics, 2018 Jan 02; 8(1). PMID: 29290791    Free PMC article.
Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis.
Thaiz F Borin, Kartik Angara, +2 authors, Ali S Arbab.
Int J Mol Sci, 2018 Jan 03; 18(12). PMID: 29292756    Free PMC article.
A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models.
Kader Yagiz, Maria E Rodriguez-Aguirre, +8 authors, Joan M Robbins.
Mol Ther Oncolytics, 2018 Jan 13; 8. PMID: 29322091    Free PMC article.
Chemotherapy-induced immunomodulation in non-small-cell lung cancer: a rationale for combination chemoimmunotherapy.
Hua Zheng, Masha Zeltsman, +3 authors, Prasad S Adusumilli.
Immunotherapy, 2018 Jan 18; 9(11). PMID: 29338609    Free PMC article.
Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.
Charlotte E Ariyan, Mary Sue Brady, +19 authors, James P Allison.
Cancer Immunol Res, 2018 Jan 18; 6(2). PMID: 29339377    Free PMC article.
Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma.
Qing Zhang, Kang Tian, +6 authors, Junnian Zheng.
J Immunol Res, 2018 Feb 10; 2017. PMID: 29423418    Free PMC article.
Janus-Faced Myeloid-Derived Suppressor Cell Exosomes for the Good and the Bad in Cancer and Autoimmune Disease.
Margot Zöller.
Front Immunol, 2018 Feb 20; 9. PMID: 29456536    Free PMC article.
Combination of immunotherapy with chemotherapy and radiotherapy in lung cancer: is this the beginning of the end for cancer?
Chiara Lazzari, Niki Karachaliou, +7 authors, Vanesa Gregorc.
Ther Adv Med Oncol, 2018 Apr 18; 10. PMID: 29662546    Free PMC article.
Highly Cited. Review.
Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.
Naofumi Mukaida, Yasunari Nakamoto.
World J Gastroenterol, 2018 May 10; 24(17). PMID: 29740200    Free PMC article.
Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer.
Jie Ma, Huaxi Xu, Shengjun Wang.
J Immunol Res, 2018 May 17; 2018. PMID: 29765990    Free PMC article.
Ilixadencel - an Allogeneic Cell-Based Anticancer Immune Primer for Intratumoral Administration.
Alex Karlsson-Parra, Juliana Kovacka, +4 authors, Peter Suenaert.
Pharm Res, 2018 Jun 16; 35(8). PMID: 29904904    Free PMC article.
Gemcitabine alters the proteasome composition and immunopeptidome of tumour cells.
A M Gravett, N Trautwein, +2 authors, J Copier.
Oncoimmunology, 2018 Jun 23; 7(6). PMID: 29930882    Free PMC article.
Disappearance of bone metastases in chemotherapy-resistant gastric cancer treated with antigen peptide-pulsed dendritic cell-activated cytotoxic T lymphocyte immunotherapy: A case report.
Juan Du, Jia Wei, +6 authors, Baorui Liu.
Oncol Lett, 2018 Jul 03; 16(1). PMID: 29963158    Free PMC article.
Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies.
Anna Minchom, Caterina Aversa, Juanita Lopez.
Ther Adv Med Oncol, 2018 Jul 20; 10. PMID: 30023007    Free PMC article.
Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics.
Curtis W McCloskey, Galaxia M Rodriguez, Kristianne J C Galpin, Barbara C Vanderhyden.
Cancers (Basel), 2018 Jul 28; 10(8). PMID: 30049987    Free PMC article.
The blood mMDSC to DC ratio is a sensitive and easy to assess independent predictive factor for epithelial ovarian cancer survival.
S J A M Santegoets, A F de Groot, +6 authors, S H van der Burg.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221063    Free PMC article.
Prophylactic vs. Therapeutic Treatment With P2Et Polyphenol-Rich Extract Has Opposite Effects on Tumor Growth.
Paola Lasso, Alejandra Gomez-Cadena, +5 authors, Susana Fiorentino.
Front Oncol, 2018 Sep 21; 8. PMID: 30234017    Free PMC article.
Potentiating cancer vaccine efficacy in liver cancer.
Maria Tagliamonte, Annacarmen Petrizzo, +3 authors, Luigi Buonaguro.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288355    Free PMC article.
Positive & Negative Roles of Innate Effector Cells in Controlling Cancer Progression.
Dorian Stolk, Hans J van der Vliet, +2 authors, Mark A Exley.
Front Immunol, 2018 Oct 10; 9. PMID: 30298063    Free PMC article.
Translational Potential of Therapeutics Targeting Regulatory Myeloid Cells in Tuberculosis.
Nelita du Plessis, Leigh A Kotze, Vinzeigh Leukes, Gerhard Walzl.
Front Cell Infect Microbiol, 2018 Oct 10; 8. PMID: 30298121    Free PMC article.
Immunogenic effects of chemotherapy-induced tumor cell death.
Yi-Jun Wang, Rochelle Fletcher, Jian Yu, Lin Zhang.
Genes Dis, 2018 Oct 16; 5(3). PMID: 30320184    Free PMC article.
Highly Cited. Review.
Fusobacterium and Colorectal Cancer.
Ziwei Zhou, Jiewen Chen, Herui Yao, Hai Hu.
Front Oncol, 2018 Oct 31; 8. PMID: 30374420    Free PMC article.
Gemcitabine nanoparticles promote antitumor immunity against melanoma.
Yuan Zhang, Xin Bush, Bingfang Yan, Justin A Chen.
Biomaterials, 2018 Nov 06; 189. PMID: 30388589    Free PMC article.
Combination Therapy with EpCAM-CAR-NK-92 Cells and Regorafenib against Human Colorectal Cancer Models.
Qing Zhang, Haixu Zhang, +7 authors, Junnian Zheng.
J Immunol Res, 2018 Nov 10; 2018. PMID: 30410941    Free PMC article.
Tumor Microenvironment following Gemcitabine Treatment Favors Differentiation of Immunosuppressive Ly6Chigh Myeloid Cells.
Caijun Wu, Xiaobin Tan, +3 authors, Chuanlin Ding.
J Immunol, 2019 Nov 30; 204(1). PMID: 31776206    Free PMC article.
Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells.
Jihyun Lim, Aram Lee, Hee Gu Lee, Jong-Seok Lim.
Biomol Ther (Seoul), 2019 Aug 23; 28(1). PMID: 31431006    Free PMC article.
Overcoming malignant cell-based mechanisms of resistance to immune checkpoint blockade antibodies.
Reham Ajina, David J Zahavi, Yong-Wei Zhang, Louis M Weiner.
Semin Cancer Biol, 2019 Dec 24; 65. PMID: 31866479    Free PMC article.
Myeloid-driven mechanisms as barriers to antitumor CD8+ T cell activity.
Sean H Colligan, Stephanie L Tzetzo, Scott I Abrams.
Mol Immunol, 2019 Dec 31; 118. PMID: 31884388    Free PMC article.
Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d-/- Mice Lacking NKT Cells.
Shun Takaku, Masumi Shimizu, Hidemi Takahashi.
Integr Cancer Ther, 2020 Jan 22; 19. PMID: 31959018    Free PMC article.
Analysis of the association between prior chemotherapy regimens and outcomes of subsequent anti-PD-(L)1 monotherapy in advanced non-small cell lung cancer.
Guanghui Gao, Keyi Jia, +7 authors, Caicun Zhou.
Transl Lung Cancer Res, 2020 Feb 06; 8(6). PMID: 32010570    Free PMC article.
Immunobiology of cholangiocarcinoma.
Emilien Loeuillard, Caitlin B Conboy, Gregory J Gores, Sumera Rizvi.
JHEP Rep, 2020 Feb 11; 1(4). PMID: 32039381    Free PMC article.
Targeting the tumor microenvironment in pancreatic ductal adenocarcinoma.
Veethika Pandey, Peter Storz.
Expert Rev Anticancer Ther, 2019 Jun 01; 19(6). PMID: 31148495    Free PMC article.
Nanomaterials for modulating innate immune cells in cancer immunotherapy.
Quoc-Viet Le, Geon Yang, +3 authors, Yu-Kyoung Oh.
Asian J Pharm Sci, 2020 Feb 28; 14(1). PMID: 32104435    Free PMC article.
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
Andrea J Luker, Laura J Graham, +7 authors, Rebecca K Martin.
BMC Immunol, 2020 Feb 29; 21(1). PMID: 32106810    Free PMC article.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han.
J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595    Free PMC article.
Highly Cited. Review.
Immune-checkpoint inhibitor plus chemotherapy versus conventional chemotherapy for first-line treatment in advanced non-small cell lung carcinoma: a systematic review and meta-analysis.
Yixin Zhou, Chen Chen, +10 authors, Li Zhang.
J Immunother Cancer, 2018 Dec 24; 6(1). PMID: 30577837    Free PMC article.
Systematic Review.
Oxaliplatin regulates myeloid-derived suppressor cell-mediated immunosuppression via downregulation of nuclear factor-κB signaling.
Na-Rae Kim, Yeon-Jeong Kim.
Cancer Med, 2018 Dec 29; 8(1). PMID: 30592157    Free PMC article.
Advances in immunotherapy delivery from implantable and injectable biomaterials.
David G Leach, Simon Young, Jeffrey D Hartgerink.
Acta Biomater, 2019 Feb 17; 88. PMID: 30771535    Free PMC article.
Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment.
Hari Menon, Rishab Ramapriyan, +13 authors, James W Welsh.
Front Immunol, 2019 Mar 05; 10. PMID: 30828330    Free PMC article.
Highly Cited. Review.
Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy.
Quoc-Viet Le, Juhan Suh, Yu-Kyoung Oh.
AAPS J, 2019 May 19; 21(4). PMID: 31102154
Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence.
Chanyoung Song, Hathaichanok Phuengkham, +13 authors, Yong Taik Lim.
Nat Commun, 2019 Aug 23; 10(1). PMID: 31431623    Free PMC article.
Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs.
Momir Bosiljcic, Rachel A Cederberg, +11 authors, Kevin L Bennewith.
Breast Cancer Res, 2019 Sep 07; 21(1). PMID: 31488209    Free PMC article.
Low-Dose Gemcitabine Treatment Enhances Immunogenicity and Natural Killer Cell-Driven Tumor Immunity in Lung Cancer.
Xin Zhang, Dong Wang, +5 authors, Lijun Xu.
Front Immunol, 2020 Mar 13; 11. PMID: 32161598    Free PMC article.
The emerging role of myeloid-derived suppressor cells in radiotherapy.
Changhee Kang, Seong-Yun Jeong, Si Yeol Song, Eun Kyung Choi.
Radiat Oncol J, 2020 Apr 02; 38(1). PMID: 32229803    Free PMC article.
Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real-world data of advanced urothelial carcinoma.
Nobuki Furubayashi, Takahito Negishi, +4 authors, Motonobu Nakamura.
Oncol Lett, 2020 Apr 08; 19(4). PMID: 32256805    Free PMC article.
Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment.
Heidi Harjunpää, Marc Llort Asens, Carla Guenther, Susanna C Fagerholm.
Front Immunol, 2019 Jun 25; 10. PMID: 31231358    Free PMC article.
Highly Cited. Review.
Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD).
Anu Kauppinen, Kai Kaarniranta, Antero Salminen.
Front Immunol, 2020 Apr 09; 11. PMID: 32265903    Free PMC article.
Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression.
Antonino Bruno, Lorenzo Mortara, +2 authors, Adriana Albini.
Front Immunol, 2019 May 07; 10. PMID: 31057536    Free PMC article.
Highly Cited. Review.
Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer.
Andrew M K Law, Fatima Valdes-Mora, David Gallego-Ortega.
Cells, 2020 Mar 04; 9(3). PMID: 32121014    Free PMC article.
Different sensitivities of senescent breast cancer cells to immune cell-mediated cytotoxicity.
Touko Inao, Hitoshi Kotani, +5 authors, Mamoru Harada.
Cancer Sci, 2019 Jun 30; 110(9). PMID: 31250942    Free PMC article.
The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer.
Nadège Bercovici, Marion V Guérin, Alain Trautmann, Emmanuel Donnadieu.
Front Immunol, 2019 Jul 30; 10. PMID: 31354719    Free PMC article.
Visualization and quantification of in vivo homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer.
Sabrina H L Hoffmann, Dorothea I Reck, +13 authors, Christoph M Griessinger.
Theranostics, 2019 Sep 20; 9(20). PMID: 31534525    Free PMC article.
Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy.
Michael J Gough, Shay Sharon, Marka R Crittenden, Kristina H Young.
Semin Radiat Oncol, 2020 May 10; 30(2). PMID: 32381295    Free PMC article.
The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment.
Yajing Mi, Na Guo, +5 authors, Xingchun Gao.
Front Immunol, 2020 May 12; 11. PMID: 32391020    Free PMC article.
Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade.
B R Heath, N L Michmerhuizen, +4 authors, Y L Lei.
J Dent Res, 2019 Jul 26; 98(10). PMID: 31340724    Free PMC article.
Hyperprogression and impact of tumor growth kinetics after PD1/PDL1 inhibition in head and neck squamous cell carcinoma.
Andy Karabajakian, Thibaut Garrivier, +8 authors, Jérôme Fayette.
Oncotarget, 2020 May 15; 11(18). PMID: 32405337    Free PMC article.
Adding combination immunotherapy consisting of cancer vaccine, anti-PD-1 and anti-CSF1R antibodies to gemcitabine improves anti-tumor efficacy in murine model of pancreatic ductal adenocarcinoma.
May Tun Saung, Lei Zheng.
Ann Pancreat Cancer, 2020 May 15; 2. PMID: 32405624    Free PMC article.
Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy.
Zhaoting Li, Yixin Wang, +3 authors, Minjie Sun.
Sci Adv, 2020 May 23; 6(20). PMID: 32440550    Free PMC article.
Immune System Stimulation by Oncolytic Rodent Protoparvoviruses.
Assia Angelova, Jean Rommelaere.
Viruses, 2019 May 08; 11(5). PMID: 31060205    Free PMC article.
Current Clinical Progress of PD-1/PD-L1 Immunotherapy and Potential Combination Treatment in Non-Small Cell Lung Cancer.
Jia-Xin Li, Ju-Min Huang, +4 authors, Pei-Yu Yan.
Integr Cancer Ther, 2019 Dec 17; 18. PMID: 31838881    Free PMC article.
Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus.
Anca Dorhoi, Leigh A Kotzé, +13 authors, Nelita du Plessis.
J Clin Invest, 2020 May 19; 130(6). PMID: 32420917    Free PMC article.
Treating Japanese Patients With Pembrolizumab for Platinum-Refractory Advanced Urothelial Carcinoma in Real-World Clinical Practice.
Nobuki Furubayashi, Kentaro Kuroiwa, +7 authors, Motonobu Nakamura.
J Clin Med Res, 2020 Jun 04; 12(5). PMID: 32489505    Free PMC article.
Lifting the innate immune barriers to antitumor immunity.
Carla V Rothlin, Sourav Ghosh.
J Immunother Cancer, 2020 Apr 11; 8(1). PMID: 32273348    Free PMC article.
Targeting Myeloid-Derived Suppressor Cell, a Promising Strategy to Overcome Resistance to Immune Checkpoint Inhibitors.
Aohan Hou, Kaiyu Hou, +2 authors, Wanling Chen.
Front Immunol, 2020 Jun 09; 11. PMID: 32508809    Free PMC article.
The future of cancer immunotherapy: microenvironment-targeting combinations.
Yonina R Murciano-Goroff, Allison Betof Warner, Jedd D Wolchok.
Cell Res, 2020 May 30; 30(6). PMID: 32467593    Free PMC article.
High PD-1 expression level is associated with an unfavorable prognosis in patients with cervical adenocarcinoma.
Masako Ishikawa, Kentaro Nakayama, +9 authors, Satoru Kyo.
Arch Gynecol Obstet, 2020 May 22; 302(1). PMID: 32435885    Free PMC article.
Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.
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Int J Biol Sci, 2020 Jun 19; 16(12). PMID: 32549755    Free PMC article.
Stem cell factor produced by tumor cells expands myeloid-derived suppressor cells in mice.
Wei-Chen Lee, Pao-Yueh Hsu, Hsiu-Ying Hsu.
Sci Rep, 2020 Jul 11; 10(1). PMID: 32647215    Free PMC article.
Gr-1highLy6G+Myeloid-derived suppressor cells and their role in a murine model of non-alcoholic steatohepatitis.
Yue Li, Ning Li, Jinchun Liu, Xiuqin An.
Am J Transl Res, 2020 Jul 14; 12(6). PMID: 32655813    Free PMC article.
Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy.
Chao Chen, Lirong Tan, +6 authors, Cong Peng.
Mediators Inflamm, 2020 Jul 21; 2020. PMID: 32684837    Free PMC article.
Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors.
Magalie Dosset, Elodie Lauret-Marie Joseph, Thaiz Rivera Vargas, Lionel Apetoh.
Cells, 2020 Jul 28; 9(7). PMID: 32707692    Free PMC article.
Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors.
Qingyang Lei, Dan Wang, +2 authors, Yi Zhang.
Front Cell Dev Biol, 2020 Aug 15; 8. PMID: 32793604    Free PMC article.
Oxazaphosphorines combined with immune checkpoint blockers: dose-dependent tuning between immune and cytotoxic effects.
Julia Delahousse, Charles Skarbek, +3 authors, Angelo Paci.
J Immunother Cancer, 2020 Aug 14; 8(2). PMID: 32784216    Free PMC article.
Combination of Immune Checkpoint Inhibitors with Chemotherapy in Lung Cancer.
Wei Liu, Lei Zhang, +6 authors, Jianhui Cai.
Onco Targets Ther, 2020 Aug 18; 13. PMID: 32801752    Free PMC article.
Intratumoral Immunotherapy for Early-stage Solid Tumors.
Wan Xing Hong, Sarah Haebe, +4 authors, Ronald Levy.
Clin Cancer Res, 2020 Feb 20; 26(13). PMID: 32071116    Free PMC article.
Combination of thermally ablative focused ultrasound with gemcitabine controls breast cancer via adaptive immunity.
Natasha D Sheybani, Alexandra R Witter, +3 authors, Richard J Price.
J Immunother Cancer, 2020 Aug 21; 8(2). PMID: 32819975    Free PMC article.
The Proteomic Effects of Pulsed Focused Ultrasound on Tumor Microenvironments of Murine Melanoma and Breast Cancer Models.
Omer Aydin, Parwathy Chandran, +3 authors, Joseph A Frank.
Ultrasound Med Biol, 2019 Sep 19; 45(12). PMID: 31530419    Free PMC article.
Negative regulation of myeloid-derived suppressor cells in cancer.
Peng Qu, Kimberly C Boelte, P Charles Lin.
Immunol Invest, 2012 Sep 29; 41(6-7). PMID: 23017135    Free PMC article.
Chemotherapy and CDK4/6 Inhibitors: Unexpected Bedfellows.
Patrick J Roberts, Vishnu Kumarasamy, Agnieszka K Witkiewicz, Erik S Knudsen.
Mol Cancer Ther, 2020 Jun 18; 19(8). PMID: 32546660    Free PMC article.
Role of Tumor-Associated Myeloid Cells in Breast Cancer.
Yoon Jin Cha, Ja Seung Koo.
Cells, 2020 Jul 31; 9(8). PMID: 32726950    Free PMC article.
Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV+ Cancers.
Gabriele Galliverti, Stephan Wullschleger, +7 authors, Douglas Hanahan.
Cancer Immunol Res, 2019 Nov 28; 8(1). PMID: 31771984    Free PMC article.
Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal.
Clara S Mundry, Kirsten C Eberle, +2 authors, Kamiya Mehla.
Biochim Biophys Acta Rev Cancer, 2020 Jun 25; 1874(1). PMID: 32579889    Free PMC article.
Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System.
Shweta Joshi, Donald L Durden.
J Oncol, 2019 Mar 12; 2019. PMID: 30853982    Free PMC article.
Combined Checkpoint Inhibition and Chemotherapy: New Era of 1st-Line Treatment for Non-Small-Cell Lung Cancer.
Chongkai Wang, Prakash Kulkarni, Ravi Salgia.
Mol Ther Oncolytics, 2019 Apr 13; 13. PMID: 30976658    Free PMC article.
Dendritic Cells and Cancer: From Biology to Therapeutic Intervention.
Ben Wylie, Christophe Macri, Justine D Mintern, Jason Waithman.
Cancers (Basel), 2019 Apr 14; 11(4). PMID: 30979057    Free PMC article.
Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma.
Woong-Jai Won, Jessy S Deshane, +2 authors, Corinne E Griguer.
Cell Stress, 2019 Jun 22; 3(2). PMID: 31225500    Free PMC article.
Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect).
Eonju Oh, Bokyung Min, +7 authors, Chae-Ok Yun.
Cancers (Basel), 2019 Jul 22; 11(7). PMID: 31324057    Free PMC article.
Immunomodulatory Nanosystems.
Xiangru Feng, Weiguo Xu, +3 authors, Xuesi Chen.
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Cell Stress, 2019 Sep 20; 3(9). PMID: 31535085    Free PMC article.
Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance.
Charita Furumaya, Paula Martinez-Sanz, +2 authors, Hanke L Matlung.
Front Immunol, 2020 Sep 29; 11. PMID: 32983165    Free PMC article.
CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy.
Anne Y Lai, Jessica A Sorrentino, +8 authors, Patrick J Roberts.
J Immunother Cancer, 2020 Oct 03; 8(2). PMID: 33004541    Free PMC article.
Immunogenic chemotherapy in two mouse colon cancer models.
Takahito Taniura, Yuichi Iida, +3 authors, Mamoru Harada.
Cancer Sci, 2020 Aug 21; 111(10). PMID: 32816355    Free PMC article.
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine.
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud.
Open Biol, 2020 Sep 16; 10(9). PMID: 32931721    Free PMC article.
Implications of metabolism-driven myeloid dysfunctions in cancer therapy.
Laura Strauss, Valentina Guarneri, Alessandra Gennari, Antonio Sica.
Cell Mol Immunol, 2020 Oct 21; 18(4). PMID: 33077904    Free PMC article.
In vivo vaccination with cell line-derived whole tumor lysates: neoantigen quality, not quantity matters.
Inken Salewski, Yvonne Saara Gladbach, +4 authors, Claudia Maletzki.
J Transl Med, 2020 Oct 23; 18(1). PMID: 33087163    Free PMC article.
Prognostic and Predictive Value of Tumor-Infiltrating Immune Cells in Urothelial Cancer of the Bladder.
Sandra van Wilpe, Eveline C F Gerretsen, +3 authors, Niven Mehra.
Cancers (Basel), 2020 Sep 25; 12(9). PMID: 32967190    Free PMC article.
In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination.
Giorgia Mandili, Claudia Curcio, +12 authors, Francesco Novelli.
J Immunother Cancer, 2020 Oct 30; 8(2). PMID: 33115943    Free PMC article.
Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice.
Benson Chellakkan Selvanesan, Kiran Meena, +4 authors, Claudia Gravekamp.
J Immunother Cancer, 2020 Nov 07; 8(2). PMID: 33154149    Free PMC article.
A narrative review of synergistic drug administration in unresectable locally advanced non-small cell lung cancer: current landscape and future prospects in the era of immunotherapy.
Shuyan Li, Xiao Chu, +2 authors, Zhengfei Zhu.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209628    Free PMC article.
Immune suppression: the hallmark of myeloid derived suppressor cells.
Lydia A Haile, Tim F Greten, Firouzeh Korangy.
Immunol Invest, 2012 Sep 29; 41(6-7). PMID: 23017136    Free PMC article.
Myeloid-derived suppressor cells: The green light for myeloma immune escape.
Ehsan Malek, Marcos de Lima, +4 authors, Sergio A Giralt.
Blood Rev, 2016 May 02; 30(5). PMID: 27132116    Free PMC article.
The clinical evidence for targeting human myeloid-derived suppressor cells in cancer patients.
Richard P Tobin, Dana Davis, Kimberly R Jordan, Martin D McCarter.
J Leukoc Biol, 2017 Feb 10; 102(2). PMID: 28179538    Free PMC article.
Myeloid-derived suppressor cells-a new therapeutic target to overcome resistance to cancer immunotherapy.
Jason A Chesney, Robert A Mitchell, Kavitha Yaddanapudi.
J Leukoc Biol, 2017 May 27; 102(3). PMID: 28546500    Free PMC article.
STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells.
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Oncogene, 2018 Aug 31; 38(4). PMID: 30158673
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Targeting myeloid regulators by paclitaxel-loaded enzymatically degradable nanocups.
Seth C Burkert, Galina V Shurin, +5 authors, Alexander Star.
Nanoscale, 2018 Sep 19; 10(37). PMID: 30226240    Free PMC article.
Advances in engineering local drug delivery systems for cancer immunotherapy.
Peter Abdou, Zejun Wang, +4 authors, Zhen Gu.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020 Apr 08; 12(5). PMID: 32255276    Free PMC article.
IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates.
Wenjing Song, Youcheng Shao, +6 authors, Jingwei Zhang.
Front Mol Biosci, 2020 Dec 17; 7. PMID: 33324675    Free PMC article.
Implantable and Injectable Biomaterial Scaffolds for Cancer Immunotherapy.
Jie Li, Yiqian Luo, +3 authors, Changfeng Fu.
Front Bioeng Biotechnol, 2020 Dec 18; 8. PMID: 33330440    Free PMC article.
Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma.
Jun Cai, Panpan Liu, +11 authors, Qingqing Cai.
Signal Transduct Target Ther, 2020 Dec 31; 5(1). PMID: 33376237    Free PMC article.
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors.
Lorenzo Galluzzi, Juliette Humeau, +2 authors, Guido Kroemer.
Nat Rev Clin Oncol, 2020 Aug 08; 17(12). PMID: 32760014
Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors.
Jim Middelburg, Kristel Kemper, +3 authors, Thorbald van Hall.
Cancers (Basel), 2021 Jan 21; 13(2). PMID: 33466732    Free PMC article.
Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer.
Shuang Zhang, Sonia Iyer, +10 authors, Benjamin G Neel.
Cancer Discov, 2020 Nov 08; 11(2). PMID: 33158842    Free PMC article.
Combinations using checkpoint blockade to overcome resistance.
Stefania Morganti, Giuseppe Curigliano.
Ecancermedicalscience, 2021 Feb 13; 14. PMID: 33574893    Free PMC article.
Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer.
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura.
Cells, 2021 Feb 11; 10(2). PMID: 33562495    Free PMC article.
An Inflammatory Loop Between Spleen-Derived Myeloid Cells and CD4+ T Cells Leads to Accumulation of Long-Lived Plasma Cells That Exacerbates Lupus Autoimmunity.
Eunkyeong Jang, Somi Cho, +2 authors, Jeehee Youn.
Front Immunol, 2021 Mar 02; 12. PMID: 33643317    Free PMC article.
Immune monitoring in mesothelioma patients identifies novel immune-modulatory functions of gemcitabine associating with clinical response.
Floris Dammeijer, Cornedine J De Gooijer, +16 authors, Joachim G Aerts.
EBioMedicine, 2021 Feb 01; 64. PMID: 33516644    Free PMC article.
Interaction Between MDSC and NK Cells in Solid and Hematological Malignancies: Impact on HSCT.
Nicola Tumino, Anna Laura Di Pace, +3 authors, Lorenzo Moretta.
Front Immunol, 2021 Mar 09; 12. PMID: 33679798    Free PMC article.
History of Extensive Disease Small Cell Lung Cancer Treatment: Time to Raise the Bar? A Review of the Literature.
Chiara Lazzari, Aurora Mirabile, +8 authors, Vanesa Gregorc.
Cancers (Basel), 2021 Mar 07; 13(5). PMID: 33673630    Free PMC article.
Therapeutic cancer vaccines.
Mansi Saxena, Sjoerd H van der Burg, Cornelis J M Melief, Nina Bhardwaj.
Nat Rev Cancer, 2021 Apr 29; 21(6). PMID: 33907315
Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment.
Jennifer Frosch, Ilia Leontari, John Anderson.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33917501    Free PMC article.
Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies.
Yongchao Wang, Jinjin Wang, +5 authors, Xing-Jie Liang.
Acta Pharm Sin B, 2021 May 18; 11(4). PMID: 33996405    Free PMC article.
[Application of Neoadjuvant Immuno-chemotherapy in NSCLC].
Si Chen, Zerui Zhao, Hao Long.
Zhongguo Fei Ai Za Zhi, 2021 Apr 30; 24(4). PMID: 33910277    Free PMC article.
Myeloid-Derived Suppressor Cells as Therapeutic Targets in Uterine Cervical and Endometrial Cancers.
Seiji Mabuchi, Tomoyuki Sasano.
Cells, 2021 May 06; 10(5). PMID: 33946532    Free PMC article.
Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy.
Cristina Zalfa, Silke Paust.
Front Immunol, 2021 May 25; 12. PMID: 34025641    Free PMC article.
Chinese Herbal Prescription Fu-Zheng-Qu-Xie Prevents Recurrence and Metastasis of Postoperative Early-Stage Lung Adenocarcinoma: A Prospective Cohort Study Followed with Potential Mechanism Exploration.
Sufang Zhang, Wanqing Chen, +9 authors, Yan Li.
Oxid Med Cell Longev, 2021 Jun 01; 2021. PMID: 34055197    Free PMC article.
Effects of Chemotherapy Agents on Circulating Leukocyte Populations: Potential Implications for the Success of CAR-T Cell Therapies.
Nga T H Truong, Tessa Gargett, Michael P Brown, Lisa M Ebert.
Cancers (Basel), 2021 Jun 03; 13(9). PMID: 34066414    Free PMC article.
Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β.
Anjan K Pradhan, Santanu Maji, +12 authors, Paul B Fisher.
Proc Natl Acad Sci U S A, 2021 May 22; 118(21). PMID: 34016751    Free PMC article.
Therapeutic Targets and Tumor Microenvironment in Colorectal Cancer.
Gaetano Gallo, Giuseppina Vescio, Gilda De Paola, Giuseppe Sammarco.
J Clin Med, 2021 Jun 03; 10(11). PMID: 34070480    Free PMC article.
Recent Advancements in Nanomedicine for 'Cold' Tumor Immunotherapy.
Qinjun Chen, Tao Sun, Chen Jiang.
Nanomicro Lett, 2021 Jun 18; 13(1). PMID: 34138315    Free PMC article.
Role of betulinic acid derivative SH-479 in triple negative breast cancer and bone microenvironment.
Liang Tang, Shu Jun Lv, +11 authors, Haifeng Wei.
Oncol Lett, 2021 Jul 01; 22(2). PMID: 34188707    Free PMC article.
Inflammation and tumor progression: signaling pathways and targeted intervention.
Huakan Zhao, Lei Wu, +4 authors, Yongsheng Li.
Signal Transduct Target Ther, 2021 Jul 13; 6(1). PMID: 34248142    Free PMC article.
Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism.
Mary P Udumula, Sharif Sakr, +11 authors, Ramandeep Rattan.
Mol Metab, 2021 Jun 19; 53. PMID: 34144215    Free PMC article.
Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target.
Ehsan Nourbakhsh, Ali Mohammadi, +2 authors, Farnoosh Ebrahimzadeh.
Inflammopharmacology, 2021 Jul 21; 29(5). PMID: 34283371
A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model.
Jamile Ramos da Silva, Ana Carolina Ramos Moreno, +9 authors, Luís Carlos de Souza Ferreira.
Oncoimmunology, 2021 Aug 10; 10(1). PMID: 34367730    Free PMC article.
The safety and efficacy of chemotherapy combined with immunotherapy for pancreatic cancer: A meta-analysis.
Yang Huang, Xu Yan, +3 authors, Chunyang Zhang.
Medicine (Baltimore), 2021 Aug 17; 100(29). PMID: 34398033    Free PMC article.
Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy.
Menka Khoobchandani, Aslam Khan, +7 authors, Kattesh V Katti.
Sci Rep, 2021 Aug 20; 11(1). PMID: 34408231    Free PMC article.
Targeting MDSC for Immune-Checkpoint Blockade in Cancer Immunotherapy: Current Progress and New Prospects.
Tianhang Li, Tianyao Liu, +5 authors, Rong Yang.
Clin Med Insights Oncol, 2021 Aug 20; 15. PMID: 34408525    Free PMC article.
Activation of autophagy reverses gemcitabine-induced immune inhibition of RAW264.7 macrophages by promoting TNF-α, IL-6 and MHC-II expression.
Shanshan Jiang, Rong Wang, +5 authors, Yongfang Yuan.
Immunol Res, 2021 Jul 15; 69(4). PMID: 34259987    Free PMC article.
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities.
Umar Mehraj, Rais A Ganai, +10 authors, Nissar Ahmad Wani.
Cell Oncol (Dordr), 2021 Sep 17; 44(6). PMID: 34528143
Cancer immunotherapy: it's time to better predict patients' response.
Charlotte Pilard, Marie Ancion, +3 authors, Michael Herfs.
Br J Cancer, 2021 Jun 12; 125(7). PMID: 34112949    Free PMC article.
Strategies to sensitize cancer cells to immunotherapy.
Andrew George, Ilyas Sahin, +3 authors, Wafik S El-Deiry.
Hum Vaccin Immunother, 2021 May 22; 17(8). PMID: 34019474    Free PMC article.
Combination strategies to maximize the benefits of cancer immunotherapy.
Shaoming Zhu, Tian Zhang, +5 authors, Chong-Xian Pan.
J Hematol Oncol, 2021 Sep 29; 14(1). PMID: 34579759    Free PMC article.
Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases.
Zhiguo Ling, Chuan Yang, +2 authors, Yueqi Chen.
Cell Mol Life Sci, 2021 Oct 13; 78(23). PMID: 34635950
Neutrophil-suppressive activity over T-cell proliferation and fungal clearance in a murine model of Fonsecaea pedrosoi infection.
Leandro Carvalho Dantas Breda, Cristiane Naffah de Souza Breda, +4 authors, Sandro Rogério de Almeida.
Sci Rep, 2021 Oct 14; 11(1). PMID: 34642440    Free PMC article.
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness.
Daniel Hirschhorn, Allison Betof Warner, +11 authors, Jedd D Wolchok.
JCI Insight, 2021 Oct 23; 6(20). PMID: 34676831    Free PMC article.
Successful treatment of metastatic bladder cancer by gemcitabine-cisplatin re-challenge after pembrolizumab.
Takayuki Arai, Nobuyoshi Takeuchi, +5 authors, Tomohiko Ichikawa.
IJU Case Rep, 2021 Nov 11; 4(6). PMID: 34755056    Free PMC article.
Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study.
Luis de la Cruz-Merino, María Gion, +20 authors, Federico Rojo.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771596    Free PMC article.
Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma.
Nicola Tumino, Gerrit Weber, +13 authors, Ignazio Caruana.
J Hematol Oncol, 2021 Nov 14; 14(1). PMID: 34772439    Free PMC article.
Targeting myeloid-derived suppressor cells for cancer therapy.
Hongchao Tang, Hao Li, Zhijun Sun.
Cancer Biol Med, 2021 Aug 18;. PMID: 34403220    Free PMC article.
S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model.
Noriyuki Miyajima, Ibrahim Ragab Eissa, +13 authors, Hideki Kasuya.
Nagoya J Med Sci, 2021 Dec 18; 83(4). PMID: 34916713    Free PMC article.
Role of fibrosarcoma-induced CD11b+ myeloid cells and tumor necrosis factor-α in B cell responses.
Zibing Wang, Yuqing Liu, +7 authors, Zhihai Qin.
Oncogene, 2022 Jan 17; 41(10). PMID: 35034094
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade.
Golnaz Morad, Beth A Helmink, Padmanee Sharma, Jennifer A Wargo.
Cell, 2021 Oct 09; 184(21). PMID: 34624224    Free PMC article.
Spatial and Temporal Heterogeneity of Tumor-Infiltrating Lymphocytes in Advanced Urothelial Cancer.
Sandra van Wilpe, Mark A J Gorris, +7 authors, Niven Mehra.
Front Immunol, 2022 Jan 21; 12. PMID: 35046958    Free PMC article.
Myeloid-Derived Suppressor Cells in Solid Tumors.
Tianmiao Ma, Bernhard W Renz, +4 authors, Alexandr V Bazhin.
Cells, 2022 Jan 22; 11(2). PMID: 35053426    Free PMC article.
Antitumor effects of targeting myeloid-derived suppressive cells.
Dong Zeng, Haixia Long, Bo Zhu.
Transl Cancer Res, 2020 Sep 01; 9(9). PMID: 35117939    Free PMC article.
Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression.
Zhuang Chen, Rui Yuan, +2 authors, Zhenqiang Sun.
Front Immunol, 2022 Feb 15; 13. PMID: 35154134    Free PMC article.
Case Report: Chemotherapy and Radiotherapy Combined With DC-CIK for Pulmonary and Mediastinal Metastases From Nasopharyngeal Carcinoma.
Yi-Xiu Gan, Gui-Hua Li, +2 authors, Qing-Hua Du.
Front Oncol, 2022 Mar 08; 12. PMID: 35251965    Free PMC article.
Modulation of Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC.
Carlotta Cattolico, Peter Bailey, Simon T Barry.
Front Cell Dev Biol, 2022 Mar 12; 10. PMID: 35273962    Free PMC article.
Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets.
Zahra Abbas, Courtney George, +6 authors, Raelene Endersby.
Front Immunol, 2022 Mar 22; 13. PMID: 35309309    Free PMC article.
The pro-tumorigenic host response to cancer therapies.
Yuval Shaked.
Nat Rev Cancer, 2019 Oct 28; 19(12). PMID: 31645711
Neoadjuvant Immuno-Chemotherapy: A New Perspective for Stage III NSCLC?
Yuanshan Yao, Dongfang Tang, Wen Gao, Huibiao Zhang.
Front Surg, 2022 Apr 23; 9. PMID: 35449550    Free PMC article.
Efficacy and safety of sintilimab plus docetaxel in patients with previously treated advanced non-small cell lung cancer: a prospective, single-arm, phase II study in China.
Xiao Han, Jun Guo, +16 authors, Zhehai Wang.
J Cancer Res Clin Oncol, 2022 Apr 29;. PMID: 35482078    Free PMC article.
The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies.
Malcolm Holterhus, Bianca Altvater, Sareetha Kailayangiri, Claudia Rossig.
Cancers (Basel), 2022 May 15; 14(9). PMID: 35565307    Free PMC article.
A review of mechanisms of resistance to immune checkpoint inhibitors and potential strategies for therapy.
Yu Fujiwara, Arjun Mittra, Abdul Rafeh Naqash, Naoko Takebe.
Cancer Drug Resist, 2020 Jun 18; 3(3). PMID: 35582437    Free PMC article.
Resistance to chemoimmunotherapy in non-small-cell lung cancer.
Maximilian Johannes Hochmair.
Cancer Drug Resist, 2020 Jul 12; 3(3). PMID: 35582443    Free PMC article.