Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

Luca Gattinoni ¹, Steven E Finkelstein , Christopher A Klebanoff , Paul A Antony , Douglas C Palmer , Paul J Spiess , Leroy N Hwang , Zhiya Yu , Claudia Wrzesinski , David M Heimann , Charles D Surh , Steven A Rosenberg , Nicholas P Restifo

Affiliations

¹ Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

PMID: 16203864
28 References
478 citations

Abstract

Depletion of immune elements before adoptive cell transfer (ACT) can dramatically improve the antitumor efficacy of transferred CD8+ T cells, but the specific mechanisms that contribute to this enhanced immunity remain poorly defined. Elimination of CD4+CD25+ regulatory T (T reg) cells has been proposed as a key mechanism by which lymphodepletion augments ACT-based immunotherapy. We found that even in the genetic absence of T reg cells, a nonmyeloablative regimen substantially augmented CD8+ T cell reactivity to self-tissue and tumor. Surprisingly, enhanced antitumor efficacy and autoimmunity was caused by increased function rather than increased numbers of tumor-reactive T cells, as would be expected by homeostatic mechanisms. The gammaC cytokines IL-7 and IL-15 were required for augmenting T cell functionality and antitumor activity. Removal of gammaC cytokine-responsive endogenous cells using antibody or genetic means resulted in the enhanced antitumor responses similar to those seen after nonmyeloablative conditioning. These data indicate that lymphodepletion removes endogenous cellular elements that act as sinks for cytokines that are capable of augmenting the activity of self/tumor-reactive CD8+ T cells. Thus, the restricted availability of homeostatic cytokines can be a contributing factor to peripheral tolerance, as well as a limiting resource for the effectiveness of tumor-specific T cells.

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CD122+CD8+ Treg suppress vaccine-induced antitumor immune responses in lymphodepleted mice. Li-Xin Wang, Yuhuan Li, +5 authors, Hong-Ming Hu. less Eur J Immunol, 2010 Feb 27; 40(5). PMID: 20186876 Free PMC article.
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Redirecting the immune response: role of adoptive T cell therapy. Anna Mondino, Valérie Dardalhon, +2 authors, Naomi Taylor. less Hum Gene Ther, 2010 Mar 06; 21(5). PMID: 20201627 Free PMC article. Review.
JAK3/STAT5/6 pathway alterations are associated with immune deviation in CD8 T cells in renal cell carcinoma patients. Elisabetta Cavalcanti, Margherita Gigante, +9 authors, Elena Ranieri. less J Biomed Biotechnol, 2010 Mar 27; 2010. PMID: 20339477 Free PMC article.
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Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects. Myriam N Bouchlaka, Doug Redelman, William J Murphy. Immunotherapy, 2010 Jul 20; 2(3). PMID: 20635904 Free PMC article. Review.
Lymphoma immunotherapy: vaccines, adoptive cell transfer and immunotransplant. Joshua Brody, Ronald Levy. Immunotherapy, 2010 Jul 20; 1(5). PMID: 20636025 Free PMC article. Review.
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. Sid P Kerkar, Pawel Muranski, +12 authors, Nicholas P Restifo. less Cancer Res, 2010 Jul 22; 70(17). PMID: 20647327 Free PMC article. Highly Cited.
Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Lis R V Antonelli, Yolanda Mahnke, +9 authors, Irini Sereti. less Blood, 2010 Jul 28; 116(19). PMID: 20660788 Free PMC article.
CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma. Mark E Dudley, Colin A Gross, +17 authors, Steven A Rosenberg. less Clin Cancer Res, 2010 Jul 30; 16(24). PMID: 20668005 Free PMC article.
Amplifying TLR-MyD88 signals within tumor-specific T cells enhances antitumor activity to suboptimal levels of weakly immunogenic tumor antigens. Degui Geng, Liqin Zheng, +4 authors, Eduardo Davila. less Cancer Res, 2010 Sep 03; 70(19). PMID: 20807806 Free PMC article.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy. Christian S Hinrichs, Zachary A Borman, +14 authors, Nicholas P Restifo. less Blood, 2010 Oct 26; 117(3). PMID: 20971955 Free PMC article. Highly Cited.
Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice. Dhanalakshmi Chinnasamy, Zhiya Yu, +6 authors, Steven A Rosenberg. less J Clin Invest, 2010 Oct 28; 120(11). PMID: 20978347 Free PMC article.
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells. Wolfgang Koestner, Martin Hapke, +9 authors, Martin G Sauer. less Blood, 2010 Nov 11; 117(3). PMID: 21063028 Free PMC article.
Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity. Yolanda Nesbeth, Jose R Conejo-Garcia. Clin Dev Immunol, 2010 Nov 16; 2010. PMID: 21076522 Free PMC article. Review.
Immunotherapy for ovarian cancer: what's next? Lana E Kandalaft, Daniel J Powell, Nathan Singh, George Coukos. J Clin Oncol, 2010 Nov 17; 29(7). PMID: 21079136 Free PMC article. Review.
Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity. Sung P Ha, Nicholas D Klemen, +8 authors, Christopher E Touloukian. less J Clin Invest, 2010 Nov 19; 120(12). PMID: 21084750 Free PMC article.
Adoptive cell therapy of prostate cancer using female mice-derived T cells that react with prostate antigens. Huanfa Yi, Xiaofei Yu, +3 authors, Xiang-Yang Wang. less Cancer Immunol Immunother, 2010 Nov 23; 60(3). PMID: 21088965 Free PMC article.
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Treatment of multiple myeloma with adoptively transferred chimeric NKG2D receptor-expressing T cells. A Barber, K R Meehan, C L Sentman. Gene Ther, 2011 Jan 07; 18(5). PMID: 21209626 Free PMC article.
T cell-tumor interaction directs the development of immunotherapies in head and neck cancer. A E Albers, L Strauss, +2 authors, T Liao, T K Hoffmann, A M Kaufmann. less Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234340 Free PMC article. Review.
Focus on adoptive T cell transfer trials in melanoma. Liat Hershkovitz, Jacob Schachter, Avraham J Treves, Michal J Besser. Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234353 Free PMC article. Review.
Contribution of the immune system to the chemotherapeutic response. Alison M McDonnell, Anna K Nowak, Richard A Lake. Semin Immunopathol, 2011 Jan 29; 33(4). PMID: 21274535 Review.
Activating systemic T-cell immunity against self tumor antigens to support oncolytic virotherapy with vesicular stomatitis virus. Phonphimon Wongthida, Rosa Maria Diaz, +7 authors, Richard Vile. less Hum Gene Ther, 2011 Mar 04; 22(11). PMID: 21366404 Free PMC article.
Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. Steven E Finkelstein, Cristina Iclozan, +15 authors, Dmitry I Gabrilovich. less Int J Radiat Oncol Biol Phys, 2011 Mar 15; 82(2). PMID: 21398051 Free PMC article.
Ex vivo gene transfer and correction for cell-based therapies. Luigi Naldini. Nat Rev Genet, 2011 Mar 30; 12(5). PMID: 21445084 Highly Cited. Review.
Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy. Carlos A Ramos, Gianpietro Dotti. Expert Opin Biol Ther, 2011 Apr 06; 11(7). PMID: 21463133 Free PMC article. Review.
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Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Steven A Rosenberg, James C Yang, +12 authors, Mark E Dudley. less Clin Cancer Res, 2011 Apr 19; 17(13). PMID: 21498393 Free PMC article. Highly Cited.
Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro. Jianping Huang, Qiong J Wang, +4 authors, Paul F Robbins. less J Immunother, 2011 Apr 19; 34(4). PMID: 21499130 Free PMC article.
Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells. Marcus O Butler, Philip Friedlander, +19 authors, Naoto Hirano. less Sci Transl Med, 2011 Apr 29; 3(80). PMID: 21525398 Free PMC article.
Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy. S Merims, X Li, +7 authors, L Zhang. less Leukemia, 2011 May 14; 25(9). PMID: 21566657 Free PMC article.
Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression. Qiao Li, Xiangming Lao, +5 authors, Alfred E Chang. less Clin Cancer Res, 2011 Jun 22; 17(15). PMID: 21690573 Free PMC article.
Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice. Christopher A Klebanoff, Luca Gattinoni, +9 authors, Nicholas P Restifo. less Clin Cancer Res, 2011 Jul 09; 17(16). PMID: 21737507 Free PMC article. Highly Cited.
Anti-tumor immune responses in immune-reconstituted mice injected with a tumor vaccine. Aili He, Wanggang Zhang, +3 authors, Kangling Xu, Jianli Wang, Yun Yang, Xingmei Chao. less Med Oncol, 2011 Jul 16; 29(3). PMID: 21761245
Engineered T cells for the adoptive therapy of B-cell chronic lymphocytic leukaemia. Philipp Koehler, Patrick Schmidt, +2 authors, Andreas A Hombach, Michael Hallek, Hinrich Abken. less Adv Hematol, 2011 Aug 13; 2012. PMID: 21837241 Free PMC article.
Chronic chemoimmunotherapy achieves cure of spontaneous murine mammary tumors via persistent blockade of posttherapy counter-regulation. Rachael B Rowswell-Turner, Jamie L Harden, +3 authors, Raji E Nair, Tao Gu, Mehmet O Kilinc, Nejat K Egilmez. less J Immunol, 2011 Sep 13; 187(8). PMID: 21908736 Free PMC article.
Synergy of brief activation of CD8 T-cells in the presence of IL-12 and adoptive transfer into lymphopenic hosts promotes tumor clearance and anti-tumor memory. C Marcela Díaz-Montero, Osama Naga, +9 authors, Mathias G Lichtenheld. less Am J Cancer Res, 2011 Sep 15; 1(7). PMID: 21915391 Free PMC article.
Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation. Allison L Bayer, Jackeline Chirinos, +4 authors, Robert B Levy. less Eur J Immunol, 2011 Sep 20; 41(12). PMID: 21928285 Free PMC article.
Multiple vaccinations: friend or foe. Sarah E Church, Shawn M Jensen, +4 authors, Bernard A Fox. less Cancer J, 2011 Sep 29; 17(5). PMID: 21952289 Free PMC article. Review.
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help. Anik L Côté, Katelyn T Byrne, +2 authors, Shannon M Steinberg, Peisheng Zhang, Mary Jo Turk. less PLoS One, 2011 Nov 03; 6(10). PMID: 22046294 Free PMC article.
Targeting T cells with bispecific antibodies for cancer therapy. Lawrence G Lum, Archana Thakur. BioDrugs, 2011 Nov 05; 25(6). PMID: 22050339 Free PMC article. Review.
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. Sid P Kerkar, Romina S Goldszmid, +10 authors, Nicholas P Restifo. less J Clin Invest, 2011 Nov 08; 121(12). PMID: 22056381 Free PMC article. Highly Cited.
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. James N Kochenderfer, Mark E Dudley, +15 authors, Steven A Rosenberg. less Blood, 2011 Dec 14; 119(12). PMID: 22160384 Free PMC article. Highly Cited.
The confluence of stereotactic ablative radiotherapy and tumor immunology. Steven Eric Finkelstein, Robert Timmerman, +4 authors, George D Wilson. less Clin Dev Immunol, 2011 Dec 14; 2011. PMID: 22162711 Free PMC article. Review.
Exploitation of the propulsive force of chemotherapy for improving the response to cancer immunotherapy. Enrico Proietti, Federica Moschella, Imerio Capone, Filippo Belardelli. Mol Oncol, 2011 Dec 20; 6(1). PMID: 22177803 Free PMC article. Review.
Genetic engineering with T cell receptors. Ling Zhang, Richard A Morgan. Adv Drug Deliv Rev, 2011 Dec 20; 64(8). PMID: 22178904 Free PMC article. Review.
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From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors. Oana Draghiciu, Hans W Nijman, Toos Daemen. Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971 Free PMC article. Review.
Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy. Katayoun Rezvani, Agnes S M Yong, +8 authors, A John Barrett. less Cancer Immunol Immunother, 2011 Dec 27; 61(7). PMID: 22198310 Free PMC article.
Cancer immunotherapy. Thomas F Gajewski. Mol Oncol, 2012 Jan 18; 6(2). PMID: 22248437 Free PMC article. Review.
Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help. Marcus O Butler, Osamu Imataki, +10 authors, Naoto Hirano. less PLoS One, 2012 Jan 27; 7(1). PMID: 22279573 Free PMC article.
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Brian G Till, Michael C Jensen, +12 authors, Oliver W Press. less Blood, 2012 Feb 07; 119(17). PMID: 22308288 Free PMC article. Highly Cited.
Adoptive transfer with high-affinity TCR to treat human solid tumors: how to improve the feasibility? F Jotereau, N Gervois, N Labarrière. Target Oncol, 2012 Feb 22; 7(1). PMID: 22350487 Review.
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Hollie J Pegram, James C Lee, +4 authors, Renier J Brentjens. less Blood, 2012 Feb 23; 119(18). PMID: 22354001 Free PMC article. Highly Cited.
A potent vaccination strategy that circumvents lymphodepletion for effective antitumor adoptive T-cell therapy. Hyun-Il Cho, Eduardo Reyes-Vargas, Julio C Delgado, Esteban Celis. Cancer Res, 2012 Mar 01; 72(8). PMID: 22367213 Free PMC article.
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma. John H Sampson, Robert J Schmittling, +13 authors, Duane A Mitchell. less PLoS One, 2012 Mar 03; 7(2). PMID: 22383993 Free PMC article.
Cytotoxic chemotherapy and CD4+ effector T cells: an emerging alliance for durable antitumor effects. Zhi-Chun Ding, Gang Zhou. Clin Dev Immunol, 2012 Mar 09; 2012. PMID: 22400040 Free PMC article. Review.
Adoptive immunotherapy for cancer: harnessing the T cell response. Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg. Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939 Free PMC article. Highly Cited. Review.
Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor. Robert P T Somerville, Laura Devillier, +2 authors, Mark E Dudley. less J Transl Med, 2012 Apr 06; 10. PMID: 22475724 Free PMC article.
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum. Cristina Bergamaschi, Jenifer Bear, +7 authors, George N Pavlakis. less Blood, 2012 Apr 13; 120(1). PMID: 22496150 Free PMC article.
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide. Mohamed L Salem, Amir A Al-Khami, +4 authors, David J Cole. less Cell Immunol, 2012 May 09; 276(1-2). PMID: 22560674 Free PMC article.
Emerging concepts in haematopoietic cell transplantation. Hao Wei Li, Megan Sykes. Nat Rev Immunol, 2012 May 26; 12(6). PMID: 22627859 Free PMC article. Review.
Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence. Shawn M Jensen, Christopher G Twitty, +6 authors, Bernard A Fox. less J Immunol, 2012 Jun 23; 189(2). PMID: 22723522 Free PMC article.
Adoptive transfer of cytotoxic T lymphocytes targeting two different antigens limits antigen loss and tumor escape. Karen M Kaluza, Timothy Kottke, +3 authors, Richard Vile. less Hum Gene Ther, 2012 Jun 28; 23(10). PMID: 22734672 Free PMC article.
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Neoantigen and tumor antigen-specific immunity transferred from immunized donors is detectable early after allogeneic transplantation in myeloma patients. M Foglietta, S S Neelapu, +13 authors, M R Bishop. less Bone Marrow Transplant, 2012 Jul 10; 48(2). PMID: 22773122 Free PMC article.
A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model. Yogesh M Kulkarni, Emily Chambers, +3 authors, David J Klinke. less Integr Biol (Camb), 2012 Jul 11; 4(8). PMID: 22777646 Free PMC article.
Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo. Ingunn M Stromnes, Carla Fowler, +8 authors, Philip D Greenberg. less J Immunol, 2012 Jul 17; 189(4). PMID: 22798667 Free PMC article.
Current translational and clinical practices in hematopoietic cell and gene therapy. David L Digiusto, Hans-Peter Kiem. Cytotherapy, 2012 Jul 18; 14(7). PMID: 22799276 Free PMC article. Review.
A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer. Lana E Kandalaft, Daniel J Powell, George Coukos. J Transl Med, 2012 Aug 07; 10. PMID: 22863016 Free PMC article.
Adoptive immunotherapy of advanced melanoma. Ronnie Shapira-Frommer, Jacob Schachter. Curr Treat Options Oncol, 2012 Aug 07; 13(3). PMID: 22864561 Review.
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Adoptive transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of total body irradiation eradicates breast tumors. Nadine M Lerret, Magdalena Rogozinska, Andrés Jaramillo, Amanda L Marzo. PLoS One, 2012 Aug 23; 7(7). PMID: 22911764 Free PMC article.
A pharmacologic perspective on newly emerging T-cell manipulation technologies. Dominic Smethurst. Br J Clin Pharmacol, 2012 Oct 09; 76(2). PMID: 23039307 Free PMC article. Review.
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Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale. Xiuli Wang, Araceli Naranjo, +8 authors, Michael C Jensen. less J Immunother, 2012 Oct 24; 35(9). PMID: 23090078 Free PMC article.
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Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma. Krithika N Kodumudi, Amy Weber, Amod A Sarnaik, Shari Pilon-Thomas. J Immunol, 2012 Oct 27; 189(11). PMID: 23100512 Free PMC article.
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Clinical opportunities in combining immunotherapy with radiation therapy. Steven E Finkelstein, Mayer Fishman. Front Oncol, 2012 Dec 13; 2. PMID: 23233905 Free PMC article.
Radiation-induced effects and the immune system in cancer. Punit Kaur, Alexzander Asea. Front Oncol, 2012 Dec 20; 2. PMID: 23251903 Free PMC article.
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Adoptive T-cell transfer combined with a single low dose of total body irradiation eradicates breast tumors. Nadine M Lerret, Amanda L Marzo. Oncoimmunology, 2013 Mar 26; 2(2). PMID: 23525138 Free PMC article.
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice. Luis A Sanchez-Perez, Bryan D Choi, +9 authors, John H Sampson. less PLoS One, 2013 Mar 26; 8(3). PMID: 23527092 Free PMC article.
Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. James N Kochenderfer, Steven A Rosenberg. Nat Rev Clin Oncol, 2013 Apr 03; 10(5). PMID: 23546520 Free PMC article. Highly Cited. Review.
BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide. Luis Sanchez-Perez, Bryan D Choi, +9 authors, John H Sampson. less Cancer Immunol Immunother, 2013 Apr 18; 62(6). PMID: 23591978 Free PMC article.
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity. Boris Engels, Victor H Engelhard, +7 authors, Hans Schreiber. less Cancer Cell, 2013 Apr 20; 23(4). PMID: 23597565 Free PMC article.
Chemotherapy in the management of advanced cutaneous malignant melanoma. Jason J Luke, Gary K Schwartz. Clin Dermatol, 2013 Apr 24; 31(3). PMID: 23608448 Free PMC article. Review.
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma. Tyce J Kearl, Weiqing Jing, Jill A Gershan, Bryon D Johnson. J Immunol, 2013 Apr 26; 190(11). PMID: 23616570 Free PMC article.
Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice. Dhanalakshmi Chinnasamy, Eric Tran, +3 authors, Steven A Rosenberg. less Cancer Res, 2013 May 02; 73(11). PMID: 23633494 Free PMC article.
Cellular immunotherapy for carcinoma using genetically modified EGFR-specific T lymphocytes. Xikun Zhou, Jing Li, +9 authors, Yu-quan Wei. less Neoplasia, 2013 May 02; 15(5). PMID: 23633926 Free PMC article.
Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors. Paul Spear, Amorette Barber, Charles L Sentman. Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734311 Free PMC article.
An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. David A Reardon, Kai W Wucherpfennig, +8 authors, Glenn Dranoff. less Expert Rev Vaccines, 2013 Jun 12; 12(6). PMID: 23750791 Free PMC article. Review.
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Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells. Ute E Burkhardt, Ursula Hainz, +28 authors, Catherine J Wu. less J Clin Invest, 2013 Aug 06; 123(9). PMID: 23912587 Free PMC article.
CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor. Qunrui Ye, De-Gang Song, +5 authors, Daniel J Powell. less Clin Cancer Res, 2013 Sep 21; 20(1). PMID: 24045181 Free PMC article. Highly Cited.
Innate and adaptive immune cells in the tumor microenvironment. Thomas F Gajewski, Hans Schreiber, Yang-Xin Fu. Nat Immunol, 2013 Sep 21; 14(10). PMID: 24048123 Free PMC article. Highly Cited. Review.
Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. James N Kochenderfer, Mark E Dudley, +21 authors, Steven A Rosenberg. less Blood, 2013 Sep 24; 122(25). PMID: 24055823 Free PMC article. Highly Cited.
Impact of T cell selection methods in the success of clinical adoptive immunotherapy. Natalia Ramírez, Lorea Beloki, +5 authors, Eduardo Olavarría. less Cell Mol Life Sci, 2013 Oct 01; 71(7). PMID: 24077876
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Reassessing target antigens for adoptive T-cell therapy. Christian S Hinrichs, Nicholas P Restifo. Nat Biotechnol, 2013 Oct 22; 31(11). PMID: 24142051 Free PMC article. Highly Cited. Review.
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Exploiting the curative potential of adoptive T-cell therapy for cancer. Christian S Hinrichs, Steven A Rosenberg. Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329789 Free PMC article. Highly Cited. Review.
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Adoptive immunotherapy for cancer or viruses. Marcela V Maus, Joseph A Fraietta, +3 authors, Carl H June. less Annu Rev Immunol, 2014 Jan 16; 32. PMID: 24423116 Free PMC article. Highly Cited. Review.
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers. Yong Lu, Bangxing Hong, +5 authors, Qing Yi. less Proc Natl Acad Sci U S A, 2014 Jan 29; 111(6). PMID: 24469818 Free PMC article.
Boosting leukemia-specific T cell responses in patients following stem cell transplantation. Ute E Burkhardt, Catherine J Wu. Oncoimmunology, 2014 Feb 01; 2(11). PMID: 24482749 Free PMC article.
Immunotherapy for solid tumors--a review for surgeons. Abdul Saied, Venu G Pillarisetty, Steven C Katz. J Surg Res, 2014 Feb 04; 187(2). PMID: 24485876 Free PMC article. Review.
Combined treatment of murine fibrosarcoma with chemotherapy (Paclitaxel), radiotherapy, and intratumoral injection of dendritic cells. Ji-Won Byun, Hyeon-Sook Lee, +5 authors, Gwang-Seong Choi. less Ann Dermatol, 2014 Mar 22; 26(1). PMID: 24648686 Free PMC article.
Melanoma immunotherapy. Martina Sanlorenzo, Igor Vujic, +10 authors, Susanna Ortiz-Urda. less Cancer Biol Ther, 2014 Mar 22; 15(6). PMID: 24651672 Free PMC article. Review.
CD19-CAR trials. Carlos A Ramos, Barbara Savoldo, Gianpietro Dotti. Cancer J, 2014 Mar 29; 20(2). PMID: 24667955 Free PMC article. Review.
MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial. Emanuela Romano, Olivier Michielin, +8 authors, Alexandre Harari. less J Transl Med, 2014 Apr 15; 12. PMID: 24726012 Free PMC article.
Cell transfer therapy for cancer: past, present, and future. Xiaoling Qian, Xian Wang, Hongchuan Jin. J Immunol Res, 2014 Apr 18; 2014. PMID: 24741604 Free PMC article. Review.
Whole-body irradiation increases the magnitude and persistence of adoptively transferred T cells associated with tumor regression in a mouse model of prostate cancer. Lindsay K Ward-Kavanagh, Junjia Zhu, Timothy K Cooper, Todd D Schell. Cancer Immunol Res, 2014 May 08; 2(8). PMID: 24801834 Free PMC article.
Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing. Yun Ji, Natalie Abrams, +9 authors, Nicholas P Restifo. less PLoS One, 2014 May 16; 9(5). PMID: 24827921 Free PMC article.
Cancer-testis antigen 7 expression and immune responses following allogeneic stem cell transplantation for multiple myeloma. Eleanor M Tyler, Achim A Jungbluth, +2 authors, Sacha Gnjatic, Richard J O'Reilly, Guenther Koehne. less Cancer Immunol Res, 2014 Jun 05; 2(6). PMID: 24894092 Free PMC article.
Early donor chimerism levels predict relapse and survival after allogeneic stem cell transplantation with reduced-intensity conditioning. Ran Reshef, Elizabeth O Hexner, +11 authors, David L Porter. less Biol Blood Marrow Transplant, 2014 Jul 13; 20(11). PMID: 25016197 Free PMC article.
Trial Watch: Adoptive cell transfer for anticancer immunotherapy. Fernando Aranda, Erika Vacchelli, +8 authors, Lorenzo Galluzzi. less Oncoimmunology, 2014 Jul 23; 3. PMID: 25050207 Free PMC article. Review.
The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells. Dominique N Lisiero, Horacio Soto, +2 authors, Richard G Everson, Linda M Liau, Robert M Prins. less J Immunother Cancer, 2014 Jul 24; 2. PMID: 25054063 Free PMC article.
Big bang theory of stem-like T cells confirmed. Nicholas P Restifo. Blood, 2014 Jul 26; 124(4). PMID: 25061170 Free PMC article.
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. James N Kochenderfer, Mark E Dudley, +23 authors, Steven A Rosenberg. less J Clin Oncol, 2014 Aug 27; 33(6). PMID: 25154820 Free PMC article. Highly Cited.
T-cell immunotherapy: looking forward. Jacqueline Corrigan-Curay, Hans-Peter Kiem, +23 authors, Donald B Kohn. less Mol Ther, 2014 Sep 05; 22(9). PMID: 25186558 Free PMC article.
IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals. Matthew C Walsh, Erika L Pearce, +3 authors, Yongwon Choi. less J Immunol, 2014 Sep 10; 193(8). PMID: 25200954 Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy. Stephanie R Jackson, Jinyun Yuan, Ryan M Teague. Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416 Free PMC article. Review.
Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy. Mahesh Jonnalagadda, Armen Mardiros, +10 authors, Christine E Brown. less Mol Ther, 2014 Nov 05; 23(4). PMID: 25366031 Free PMC article.
Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. Eugene M Cozza, Timothy K Cooper, +2 authors, Lynn R Budgeon, Neil D Christensen, Todd D Schell. less Cancer Immunol Immunother, 2014 Nov 20; 64(3). PMID: 25408469 Free PMC article.
Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions. Matthias Piesche, Vincent T Ho, +15 authors, Glenn Dranoff. less Clin Cancer Res, 2014 Dec 30; 21(5). PMID: 25538258 Free PMC article.
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines. Yun Ji, Claudia Wrzesinski, +14 authors, Luca Gattinoni. less Proc Natl Acad Sci U S A, 2014 Dec 31; 112(2). PMID: 25548153 Free PMC article.
The inducible costimulator augments Tc17 cell responses to self and tumor tissue. Michelle H Nelson, Sreenath Kundimi, +9 authors, Chrystal M Paulos. less J Immunol, 2015 Jan 13; 194(4). PMID: 25576595 Free PMC article.
Mouse model for pre-clinical study of human cancer immunotherapy. Zhiya Ya, Yared Hailemichael, Willem Overwijk, Nicholas P Restifo. Curr Protoc Immunol, 2015 Feb 03; 108. PMID: 25640991 Free PMC article.
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement. Corey Smith, Grethe Økern, +5 authors, Rajiv Khanna. less Clin Transl Immunology, 2015 Feb 12; 4(1). PMID: 25671129 Free PMC article.
Adoptive T cell immunotherapy for cancer. Karlo Perica, Juan Carlos Varela, Mathias Oelke, Jonathan Schneck. Rambam Maimonides Med J, 2015 Feb 27; 6(1). PMID: 25717386 Free PMC article. Review.
Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care. Katherine Riccione, Carter M Suryadevara, +3 authors, Luis Sanchez-Perez. less J Vis Exp, 2015 Mar 06; (96). PMID: 25741761 Free PMC article.
Beyond consolidation: auto-SCT and immunotherapy for plasma cell myeloma. N Lendvai, A D Cohen, H J Cho. Bone Marrow Transplant, 2015 Mar 10; 50(6). PMID: 25751647 Review.
Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways. Scott M Anthony, Megan E Howard, +2 authors, Kimberly S Schluns. less PLoS One, 2015 Mar 11; 10(3). PMID: 25756182 Free PMC article.
Tumor infiltrating lymphocytes in ovarian cancer. Phillip P Santoiemma, Daniel J Powell. Cancer Biol Ther, 2015 Apr 22; 16(6). PMID: 25894333 Free PMC article. Highly Cited. Review.
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling. Jacob S Bowers, Michelle H Nelson, +6 authors, Chrystal M Paulos. less Clin Cancer Res, 2015 Apr 24; 21(11). PMID: 25904754 Free PMC article.
Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas. Catherine Flores, Christina Pham, +9 authors, Duane A Mitchell. less Oncoimmunology, 2015 May 08; 4(3). PMID: 25949916 Free PMC article.
4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling. Ho S Oh, Beom K Choi, +6 authors, Byoung S Kwon. less PLoS One, 2015 May 12; 10(5). PMID: 25962156 Free PMC article.
Genetically modified T cells in cancer therapy: opportunities and challenges. Michaela Sharpe, Natalie Mount. Dis Model Mech, 2015 Jun 03; 8(4). PMID: 26035842 Free PMC article. Review.
Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis. Pali D Shah, Qiong Zhong, +2 authors, John F McDyer. less Viral Immunol, 2015 Jun 06; 28(5). PMID: 26046830 Free PMC article.
Adoptive T-cell therapy for Leukemia. Haven R Garber, Asma Mirza, Elizabeth A Mittendorf, Gheath Alatrash. Mol Cell Ther, 2014 Jan 01; 2. PMID: 26056592 Free PMC article. Review.
A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy. Julien Valton, Valérie Guyot, +5 authors, Laurent Poirot. less Mol Ther, 2015 Jun 11; 23(9). PMID: 26061646 Free PMC article.
Systemic LPS Translocation Activates Cross-Presenting Dendritic Cells but Is Dispensable for the Breakdown of CD8+ T Cell Peripheral Tolerance in Irradiated Mice. Gabriel Espinosa-Carrasco, Marine Villard, +3 authors, Javier Hernandez. less PLoS One, 2015 Jun 16; 10(6). PMID: 26075613 Free PMC article.
Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study. David J Klinke. J Immunother Cancer, 2015 Jun 18; 3. PMID: 26082838 Free PMC article. Review.
Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy. Min Luo, Bin Shao, +7 authors, Yu-Quan Wei. less Sci Rep, 2015 Jun 23; 5. PMID: 26098663 Free PMC article.
Harnessing the Microbiome to Enhance Cancer Immunotherapy. Michelle H Nelson, Marshall A Diven, Logan W Huff, Chrystal M Paulos. J Immunol Res, 2015 Jun 24; 2015. PMID: 26101781 Free PMC article. Review.
Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies-A review. Sandeep Nayar, Prokar Dasgupta, Christine Galustian. Oncoimmunology, 2015 Jul 15; 4(4). PMID: 26155387 Free PMC article. Review.
Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy. Karlo Perica, Joan Glick Bieler, +9 authors, Jonathan P Schneck. less ACS Nano, 2015 Jul 15; 9(7). PMID: 26171764 Free PMC article.
Immunotherapy of melanoma. John B A G Haanen. EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217118 Free PMC article. Review.
Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Rα Dependent. C Bryce Johnson, Brian P Riesenberg, +7 authors, Mark P Rubinstein. less Cancer Immunol Res, 2015 Aug 25; 3(12). PMID: 26297711 Free PMC article.
Immune Modulation in Hematologic Malignancies. Madhav V Dhodapkar, Kavita M Dhodapkar. Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320065 Free PMC article. Review.
Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors. Maël Heiblig, Mohamed Elhamri, Mauricette Michallet, Xavier Thomas. World J Stem Cells, 2015 Sep 04; 7(7). PMID: 26328018 Free PMC article. Review.
CAR-T Cell Therapy for Lymphoma. Carlos A Ramos, Helen E Heslop, Malcolm K Brenner. Annu Rev Med, 2015 Sep 04; 67. PMID: 26332003 Free PMC article. Review.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells. Kyle A Wilson, Stephen R Goding, +2 authors, Harold R Neely, Kristina M Harris, Paul Andrew Antony. less Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570 Free PMC article.
miR-155 releases the brakes on antitumor T cells. Yun Ji, Luca Gattinoni. Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405586 Free PMC article.
Idiotype-specific CD4(+) T cells eradicate disseminated myeloma. O A Haabeth, A Tveita, +3 authors, M Fauskanger, K Hennig, P O Hofgaard, B Bogen. less Leukemia, 2015 Oct 10; 30(5). PMID: 26449664
Trial Watch: Adoptive cell transfer for oncological indications. Fernando Aranda, Aitziber Buqué, +11 authors, Lorenzo Galluzzi. less Oncoimmunology, 2015 Oct 10; 4(11). PMID: 26451319 Free PMC article. Review.
T-cell Exhaustion in Multiple Myeloma Relapse after Autotransplant: Optimal Timing of Immunotherapy. David J Chung, Katherine B Pronschinske, +7 authors, James W Young. less Cancer Immunol Res, 2015 Oct 16; 4(1). PMID: 26464015 Free PMC article.
T-cell receptor gene therapy--ready to go viral? Terhi Karpanen, Johanna Olweus. Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533 Free PMC article. Review.
Tumor-infiltrating lymphocytes for the treatment of metastatic cancer. M H Geukes Foppen, M Donia, I M Svane, J B A G Haanen. Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578452 Free PMC article. Review.
Chimeric Antigen Receptor T-Cells: New Approaches to Improve Their Efficacy and Reduce Toxicity. Marcela V Maus, Daniel J Powell. Cancer J, 2015 Nov 21; 21(6). PMID: 26588679 Free PMC article. Review.
Common gamma chain cytokines in combinatorial immune strategies against cancer. Stephanie R Pulliam, Roman V Uzhachenko, Samuel E Adunyah, Anil Shanker. Immunol Lett, 2015 Nov 26; 169. PMID: 26597610 Free PMC article. Review.
IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy. Karolina Pilipow, Alessandra Roberto, +3 authors, Enrico Lugli. less Cancer Res, 2015 Dec 03; 75(24). PMID: 26627006 Free PMC article. Review.
Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD. Elad Jacoby, Yinmeng Yang, +3 authors, Terry J Fry. less Blood, 2015 Dec 15; 127(10). PMID: 26660684 Free PMC article.
Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy. Madhusudhanan Sukumar, Jie Liu, +22 authors, Nicholas P Restifo. less Cell Metab, 2015 Dec 18; 23(1). PMID: 26674251 Free PMC article. Highly Cited.
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Adriana M Mujal, Julia K Gilden, +2 authors, Audrey Gérard, Makoto Kinoshita, Matthew F Krummel. less Nat Immunol, 2015 Dec 23; 17(3). PMID: 26692174 Free PMC article.
Enhancing adoptive T cell immunotherapy with microRNA therapeutics. Yun Ji, James D Hocker, Luca Gattinoni. Semin Immunol, 2015 Dec 30; 28(1). PMID: 26710685 Free PMC article. Review.
Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease. Jennifer N Brudno, Robert P T Somerville, +19 authors, James N Kochenderfer. less J Clin Oncol, 2016 Jan 27; 34(10). PMID: 26811520 Free PMC article. Highly Cited.
Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy. Hanren Dai, Yao Wang, Xuechun Lu, Weidong Han. J Natl Cancer Inst, 2016 Jan 29; 108(7). PMID: 26819347 Free PMC article. Highly Cited. Review.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen. Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth. less Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
The Promise of Chimeric Antigen Receptor Engineered T Cells in the Treatment of Hematologic Malignancies. Sarah J Nagle, Alfred L Garfall, Edward A Stadtmauer. Cancer J, 2016 Feb 04; 22(1). PMID: 26841014 Free PMC article. Review.
Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. Michelle H Nelson, Jacob S Bowers, +7 authors, Chrystal M Paulos. less J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885368 Free PMC article.
Role of memory T cell subsets for adoptive immunotherapy. Dirk H Busch, Simon P Fräßle, +2 authors, Daniel Sommermeyer, Veit R Buchholz, Stanley R Riddell. less Semin Immunol, 2016 Mar 16; 28(1). PMID: 26976826 Free PMC article. Highly Cited. Review.
A role for pre-mNK cells in tumor progression. Carolyn Rosinsky, Paul Andrew Antony. J Immunother Cancer, 2016 Mar 17; 4. PMID: 26981246 Free PMC article.
Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy. Vita Golubovskaya, Lijun Wu. Cancers (Basel), 2016 Mar 22; 8(3). PMID: 26999211 Free PMC article. Highly Cited. Review.
Strategies to genetically engineer T cells for cancer immunotherapy. Timothy T Spear, Kaoru Nagato, Michael I Nishimura. Cancer Immunol Immunother, 2016 May 04; 65(6). PMID: 27138532 Free PMC article. Review.
Opportunities in immunotherapy of ovarian cancer. G Coukos, J Tanyi, L E Kandalaft. Ann Oncol, 2016 May 04; 27 Suppl 1. PMID: 27141063 Free PMC article. Review.
Cancer immunotherapy: the beginning of the end of cancer? Sofia Farkona, Eleftherios P Diamandis, Ivan M Blasutig. BMC Med, 2016 May 07; 14. PMID: 27151159 Free PMC article. Highly Cited. Review.
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia. Aizhang Xu, Kalpana Kalyanasundaram Bhanumathy, +5 authors, Jim Xiang. less Cell Biosci, 2016 May 10; 6. PMID: 27158441 Free PMC article.
Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion. Scott M Anthony, Sarai C Rivas, +3 authors, Kimberly S Schluns. less J Immunol, 2016 May 18; 196(11). PMID: 27183627 Free PMC article.
Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors. Hiroki Torikai, Laurence Jn Cooper. Mol Ther, 2016 May 21; 24(7). PMID: 27203439 Free PMC article. Review.
CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date. Jae H Park, Mark B Geyer, Renier J Brentjens. Blood, 2016 May 22; 127(26). PMID: 27207800 Free PMC article. Highly Cited. Review.
Immune Cells in Cancer Therapy and Drug Delivery. Ceren Eyileten, Kinga Majchrzak, +8 authors, Tomasz P Rygiel. less Mediators Inflamm, 2016 May 24; 2016. PMID: 27212807 Free PMC article. Review.
Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo. Franziska Blaeschke, Uwe Thiel, +12 authors, Stefan Burdach. less Oncotarget, 2016 Jun 10; 7(28). PMID: 27281613 Free PMC article.
T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma. Syed Abbas Ali, Victoria Shi, +11 authors, James N Kochenderfer. less Blood, 2016 Jul 15; 128(13). PMID: 27412889 Free PMC article. Highly Cited.
Mechanisms of immune evasion and current status of checkpoint inhibitors in non-small cell lung cancer. Angel Qin, David G Coffey, Edus H Warren, Nithya Ramnath. Cancer Med, 2016 Jul 16; 5(9). PMID: 27416962 Free PMC article. Review.
Effect of administration timing of postchemotherapy granulocyte colony-stimulating factor on host-immune cell recovery and CD8+ T-cell response. Mohamed Labib Salem, Mohamed Nassef, +5 authors, David Cole. less J Immunotoxicol, 2016 Jul 16; 13(6). PMID: 27417188 Free PMC article.
Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells. Katrin Deiser, Diana Stoycheva, +2 authors, Ute Bank, Thomas Blankenstein, Thomas Schüler. less PLoS One, 2016 Jul 23; 11(7). PMID: 27447484 Free PMC article.
Update on use of aldesleukin for treatment of high-risk metastatic melanoma. Rodabe N Amaria, Alexandre Reuben, Zachary A Cooper, Jennifer A Wargo. Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471714 Free PMC article. Review.
A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma. Todd Crocenzi, Benjamin Cottam, +12 authors, Marka R Crittenden. less J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532020 Free PMC article.
Harnessing the immune system to improve cancer therapy. Nikos E Papaioannou, Ourania V Beniata, +2 authors, Pinelopi Samara. less Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563648 Free PMC article. Highly Cited. Review.
Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse. Saad S Kenderian, David L Porter, Saar Gill. Biol Blood Marrow Transplant, 2016 Sep 18; 23(2). PMID: 27638367 Free PMC article. Review.
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination. Anke Redeker, Ramon Arens. Front Immunol, 2016 Sep 23; 7. PMID: 27656185 Free PMC article. Review.
Generation of T cell effectors using tumor cell-loaded dendritic cells for adoptive T cell therapy. Katerina Vavrova, Petra Vrabcova, +2 authors, Dominik Filipp, Jirina Bartunkova, Rudolf Horvath. less Med Oncol, 2016 Nov 05; 33(12). PMID: 27812850
Immune Regulation in Pregnancy: A Matter of Perspective? Elizabeth A Bonney. Obstet Gynecol Clin North Am, 2016 Nov 07; 43(4). PMID: 27816154 Free PMC article. Review.
A subset of virus-specific CD161+ T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML. Abdullah Alsuliman, Muharrem Muftuoglu, +17 authors, Katayoun Rezvani. less Blood, 2016 Nov 09; 129(6). PMID: 27821506 Free PMC article.
PD-1 inhibition and treatment of advanced melanoma-role of pembrolizumab. Ali R Jazirehi, Alexandra Lim, Tam Dinh. Am J Cancer Res, 2016 Nov 09; 6(10). PMID: 27822406 Free PMC article. Review.
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity. Michael S Magee, Crystal L Kraft, +5 authors, Adam E Snook. less Oncoimmunology, 2016 Nov 18; 5(10). PMID: 27853651 Free PMC article.
The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor Efficacy. Jessica Ann Chacon, Keith Schutsky, Daniel J Powell. Vaccines (Basel), 2016 Nov 18; 4(4). PMID: 27854240 Free PMC article. Review.
Impact of Immune Deficiency on Remodeling of Maternal Resistance Vasculature 4 Weeks Postpartum in Mice. Elizabeth A Bonney, Ann Howard, +3 authors, Natalia I Gokina. less Reprod Sci, 2016 Dec 03; 24(4). PMID: 27899739 Free PMC article.
Cellular and vaccine immunotherapy for multiple myeloma. Alfred L Garfall, Edward A Stadtmauer. Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913524 Free PMC article. Review.
Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer. Michel van Gelder, Ariane Vanclée, +3 authors, Gerard M Bos. less Breast Cancer Res Treat, 2016 Dec 05; 161(3). PMID: 27915436 Free PMC article.
Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion. Sinnie Sin Man Ng, Bethany A Nagy, +6 authors, George N Pavlakis. less Clin Cancer Res, 2016 Dec 18; 23(11). PMID: 27986749 Free PMC article.
The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications. Michael Spiotto, Yang-Xin Fu, Ralph R Weichselbaum. Sci Immunol, 2016 Dec 27; 1(3). PMID: 28018989 Free PMC article.
Redirecting T cells to eradicate B-cell acute lymphoblastic leukemia: bispecific T-cell engagers and chimeric antigen receptors. I Aldoss, R C Bargou, +3 authors, S J Forman. less Leukemia, 2016 Dec 29; 31(4). PMID: 28028314 Review.
Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies. Baixin Ye, Creed M Stary, +5 authors, Xiaoxing Xiong. less J Immunol Res, 2017 Jan 25; 2017. PMID: 28116322 Free PMC article. Review.
Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy. Julien Fleurence, Sophie Fougeray, +5 authors, Stéphane Birklé. less J Immunol Res, 2017 Feb 06; 2017. PMID: 28154831 Free PMC article. Review.
Manipulation of Innate and Adaptive Immunity through Cancer Vaccines. Elias J Sayour, Duane A Mitchell. J Immunol Res, 2017 Mar 08; 2017. PMID: 28265580 Free PMC article. Review.
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis. Daniel J Neitzke, Jacob S Bowers, +7 authors, Mark P Rubinstein. less Cancer Immunol Immunother, 2017 Mar 11; 66(6). PMID: 28280853 Free PMC article.
Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion. Jacob S Bowers, Michelle H Nelson, +6 authors, Chrystal M Paulos. less JCI Insight, 2017 Mar 16; 2(5). PMID: 28289713 Free PMC article.
Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels. James N Kochenderfer, Robert P T Somerville, +19 authors, Steven A Rosenberg. less J Clin Oncol, 2017 Mar 16; 35(16). PMID: 28291388 Free PMC article. Highly Cited.
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers. Chengcheng Zhang, Zhe Wang, +20 authors, Cheng Qian. less Mol Ther, 2017 Apr 04; 25(5). PMID: 28366766 Free PMC article. Highly Cited.
CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. ZeNan L Chang, Yvonne Y Chen. Trends Mol Med, 2017 Apr 19; 23(5). PMID: 28416139 Free PMC article. Review.
β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. Kinga Majchrzak, Michelle H Nelson, +9 authors, Chrystal M Paulos. less JCI Insight, 2017 Apr 20; 2(8). PMID: 28422756 Free PMC article.
CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma. Andras Heczey, Chrystal U Louis, +15 authors, Malcolm K Brenner. less Mol Ther, 2017 Jun 13; 25(9). PMID: 28602436 Free PMC article. Highly Cited.
Cellular immunity augmentation in mainstream oncologic therapy. Daohong Chen, Xiaoshi Zhang. Cancer Biol Med, 2017 Jun 14; 14(2). PMID: 28607803 Free PMC article.
Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells. Uwe Thiel, Sebastian J Schober, +16 authors, Stefan E G Burdach. less Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638739 Free PMC article.
Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40. Aaron E Foster, Aruna Mahendravada, +15 authors, David M Spencer. less Mol Ther, 2017 Jul 13; 25(9). PMID: 28697888 Free PMC article.
Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy. James N Kochenderfer, Robert P T Somerville, +8 authors, Steven A Rosenberg. less Mol Ther, 2017 Aug 15; 25(10). PMID: 28803861 Free PMC article. Highly Cited.
The Basics of Artificial Antigen Presenting Cells in T Cell-Based Cancer Immunotherapies. Lillian R Neal, Stefanie R Bailey, +6 authors, Juan C Varela. less J Immunol Res Ther, 2017 Aug 22; 2(1). PMID: 28825053 Free PMC article.
Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells. Tomohiro Tanaka, Satoshi Watanabe, +20 authors, Toshiaki Kikuchi. less PLoS One, 2017 Aug 31; 12(8). PMID: 28854279 Free PMC article.
Chimeric antigen receptor T-cell therapies for lymphoma. Jennifer N Brudno, James N Kochenderfer. Nat Rev Clin Oncol, 2017 Sep 01; 15(1). PMID: 28857075 Highly Cited. Review.
Improvement in diagnostic and therapeutic arthrocentesis via constant compression. Tej B Bhavsar, Wilmer L Sibbitt, +9 authors, Arthur D Bankhurst. less Clin Rheumatol, 2017 Sep 16; 37(8). PMID: 28913649
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Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment. Jennifer Frosch, Ilia Leontari, John Anderson. Cancers (Basel), 2021 May 01; 13(7). PMID: 33917501 Free PMC article. Review.
Are chimeric antigen receptor T cells (CAR-T cells) the future in immunotherapy for autoimmune diseases? Yeison Santamaria-Alza, Gloria Vasquez. Inflamm Res, 2021 May 22; 70(6). PMID: 34018005 Review.
Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy. Abraham Nissani, Shaked Lev-Ari, +8 authors, Michal J Besser. less J Immunother Cancer, 2021 May 16; 9(5). PMID: 33990415 Free PMC article.
The role of small molecules in cell and gene therapy. Lewis L Brayshaw, Carlos Martinez-Fleites, +3 authors, Christopher Herring. less RSC Med Chem, 2021 May 29; 12(3). PMID: 34046619 Free PMC article. Review.
Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer. Amrendra Kumar, Reese Watkins, Anna E Vilgelm. Front Immunol, 2021 Jun 19; 12. PMID: 34140957 Free PMC article. Review.
Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy. Ramazan Rezaei, Hadi Esmaeili Gouvarchin Ghaleh, +5 authors, Akbar Ghorbani Alvanegh. less Cancer Gene Ther, 2021 Jun 24;. PMID: 34158626 Review.
Endometrial Carcinoma: Immune Microenvironment and Emerging Treatments in Immuno-Oncology. Sandrine Rousset-Rouviere, Philippe Rochigneux, +6 authors, Renaud Sabatier. less Biomedicines, 2021 Jul 03; 9(6). PMID: 34199461 Free PMC article. Review.
The "Magic Bullet" Is Here? Cell-Based Immunotherapies for Hematological Malignancies in the Twilight of the Chemotherapy Era. Nina Miazek-Zapala, Aleksander Slusarczyk, +4 authors, Malgorzata Bobrowicz. less Cells, 2021 Jul 03; 10(6). PMID: 34203935 Free PMC article. Review.
The potential of CAR T cell therapy for prostate cancer. Philipp Wolf, Jamal Alzubi, Christian Gratzke, Toni Cathomen. Nat Rev Urol, 2021 Jul 10; 18(9). PMID: 34239139 Review.
Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity. John P Murad, Dileshni Tilakawardane, +15 authors, Saul J Priceman. less Mol Ther, 2021 Mar 02; 29(7). PMID: 33647456 Free PMC article.
Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead. Kedar Kirtane, Hany Elmariah, Christine H Chung, Daniel Abate-Daga. J Immunother Cancer, 2021 Jul 25; 9(7). PMID: 34301811 Free PMC article. Review.
IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model. Eun M Yu, Eunjung Cho, +7 authors, Beom K Choi. less Cells, 2021 Aug 28; 10(8). PMID: 34440787 Free PMC article.
Engineering enhanced CAR T-cells for improved cancer therapy. Michael C Milone, Jie Xu, +4 authors, J Joseph Melenhorst. less Nat Cancer, 2021 Sep 07; 2(8). PMID: 34485921 Free PMC article. Review.
Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells. Seon-Hee Kim, Eunjung Cho, +3 authors, Yu I Kim, Chungyong Han, Beom K Choi, Byoung S Kwon. less Nat Commun, 2021 Sep 09; 12(1). PMID: 34493727 Free PMC article.
The emerging roles of the gut microbiome in allogeneic hematopoietic stem cell transplantation. Lam T Khuat, Maneesh Dave, William J Murphy. Gut Microbes, 2021 Aug 31; 13(1). PMID: 34455917 Free PMC article. Review.
Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and -γ. Sanjay Chandrasekaran, Christopher Ronald Funk, +3 authors, Edmund K Waller. less Front Immunol, 2021 Sep 14; 12. PMID: 34512641 Free PMC article. Review.
Immunotherapy of Multiple Myeloma: Promise and Challenges. Hanley N Abramson. Immunotargets Ther, 2021 Sep 17; 10. PMID: 34527606 Free PMC article. Review.
State of the CAR-T: Risk of Infections with Chimeric Antigen Receptor T-Cell Therapy and Determinants of SARS-CoV-2 Vaccine Responses. Juliet Meir, Muhammad Abbas Abid, Muhammad Bilal Abid. Transplant Cell Ther, 2021 Sep 30; 27(12). PMID: 34587552 Free PMC article. Review.
Improving CAR T-Cell Persistence. Violena Pietrobon, Lauren Anne Todd, +3 authors, Francesco Marincola. less Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639168 Free PMC article. Review.
PD-1 blockade therapy augments the antitumor effects of lymphodepletion and adoptive T cell transfer. Miho Takahashi, Satoshi Watanabe, +18 authors, Toshiaki Kikuchi. less Cancer Immunol Immunother, 2021 Oct 18;. PMID: 34657194
Optimizing the Clinical Impact of CAR-T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia: Looking Back While Moving Forward. Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, Fatemeh Rahbarizadeh. Front Immunol, 2021 Nov 16; 12. PMID: 34777381 Free PMC article. Review.
Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia. Adriana Seber, Claudio Galvão de CastroJunior, +12 authors, Henrique Bittencourt. less Hematol Transfus Cell Ther, 2021 Nov 20; 43 Suppl 2. PMID: 34794791 Free PMC article.
Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors. Kevin Conlon, Dionysios C Watson, +19 authors, George N Pavlakis. less J Immunother Cancer, 2021 Nov 21; 9(11). PMID: 34799399 Free PMC article.
T Cell Engaging Immunotherapies, Highlighting Chimeric Antigen Receptor (CAR) T Cell Therapy. Elien De Bousser, Nico Callewaert, Nele Festjens. Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885176 Free PMC article. Review.
T Cell Fitness and Autologous CAR T Cell Therapy in Haematologic Malignancy. Palak H Mehta, Salvatore Fiorenza, +3 authors, Kylie M Quinn. less Front Immunol, 2021 Dec 14; 12. PMID: 34899742 Free PMC article. Review.
Genetically engineered CAR T-immune cells for cancer therapy: recent clinical developments, challenges, and future directions. Sherien M El-Daly, Jihan Hussein. J Appl Biomed, 2019 Mar 01; 17(1). PMID: 34907752 Review.
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies. Jian-Qing Mi, Jie Xu, +4 authors, Saijuan Chen. less Front Med, 2021 Dec 19; 15(6). PMID: 34921673 Review.
Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer. Evgenii Skurikhin, Olga Pershina, +7 authors, Alexander Dygai. less Front Cell Dev Biol, 2021 Dec 21; 9. PMID: 34926461 Free PMC article. Review.
Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors. Yasushi Kimura, Mario Ghosn, +3 authors, Govindarajan Srimathveeralli. less Mol Ther Oncolytics, 2022 Jan 18; 24. PMID: 35036524 Free PMC article. Review.
Conditioning treatment with CD27 Ab enhances expansion and antitumor activity of adoptively transferred T cells in mice. Anna Wasiuk, Jeff Weidlick, +6 authors, Li-Zhen He. less Cancer Immunol Immunother, 2021 May 25; 71(1). PMID: 34028568 Free PMC article.
B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity. Aubrey S Smith, Hannah M Knochelmann, +11 authors, Chrystal M Paulos. less J Immunother Cancer, 2022 Jan 13; 10(1). PMID: 35017148 Free PMC article.
Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice. Pavlina Chuntova, Yafei Hou, +14 authors, Hideho Okada. less Neuro Oncol, 2021 Aug 05; 24(2). PMID: 34347086 Free PMC article.
The current landscape of immunotherapy for pediatric brain tumors. Eugene I Hwang, Elias J Sayour, +15 authors, Ian F Pollack. less Nat Cancer, 2022 Feb 06; 3(1). PMID: 35121998 Review.
Brain capillary obstruction during neurotoxicity in a mouse model of anti-CD19 chimeric antigen receptor T-cell therapy. Lila D Faulhaber, Anthea Q Phuong, +7 authors, Juliane Gust. less Brain Commun, 2022 Feb 17; 4(1). PMID: 35169706 Free PMC article.
The Emerging Landscape of Immune Cell Therapies. Evan W Weber, Marcela V Maus, Crystal L Mackall. Cell, 2020 Apr 04; 181(1). PMID: 32243795 Free PMC article. Review.
Eradicating tumor in a recurrent cervical cancer patient with autologous tumor-infiltrating lymphocytes and a modified lymphodepleting regimen. Jing Guo, Ning Luo, +8 authors, Zhongping Cheng. less J Immunother Cancer, 2022 Feb 19; 10(2). PMID: 35177415 Free PMC article.
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT. Jia Wei, Min Xiao, +14 authors, Liang Huang. less Signal Transduct Target Ther, 2022 Apr 12; 7(1). PMID: 35399106 Free PMC article.
BCMA-Targeted Biologic Therapies: The Next Standard of Care in Multiple Myeloma Therapy. Barry Paul, Cesar Rodriguez, Saad Z Usmani. Drugs, 2022 Apr 13; 82(6). PMID: 35412114 Review.
Optimal fludarabine lymphodepletion is associated with improved outcomes after CAR T-cell therapy. Vanessa A Fabrizio, Jaap Jan Boelens, +29 authors, Kevin J Curran. less Blood Adv, 2021 Nov 18; 6(7). PMID: 34788386 Free PMC article.
Clinical lessons learned from the first leg of the CAR T cell journey. Robbie G Majzner, Crystal L Mackall. Nat Med, 2019 Sep 11; 25(9). PMID: 31501612 Highly Cited. Review.
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Smita S Chandran, Jiaqi Ma, +19 authors, Christopher A Klebanoff. less Nat Med, 2022 Apr 29;. PMID: 35484264
Emerging Strategies in TCR-Engineered T Cells. Fang Wei, Xiao-Xia Cheng, John Zhao Xue, Shao-An Xue. Front Immunol, 2022 Apr 19; 13. PMID: 35432319 Free PMC article. Review.

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