Journal Article
. 2005 Oct; 202(7):907-12.
doi: 10.1084/jem.20050732.

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

Luca Gattinoni 1 Steven E Finkelstein  Christopher A Klebanoff  Paul A Antony  Douglas C Palmer  Paul J Spiess  Leroy N Hwang  Zhiya Yu  Claudia Wrzesinski  David M Heimann  Charles D Surh  Steven A Rosenberg  Nicholas P Restifo  
  • PMID: 16203864
  •     28 References
  •     478 citations


Depletion of immune elements before adoptive cell transfer (ACT) can dramatically improve the antitumor efficacy of transferred CD8+ T cells, but the specific mechanisms that contribute to this enhanced immunity remain poorly defined. Elimination of CD4+CD25+ regulatory T (T reg) cells has been proposed as a key mechanism by which lymphodepletion augments ACT-based immunotherapy. We found that even in the genetic absence of T reg cells, a nonmyeloablative regimen substantially augmented CD8+ T cell reactivity to self-tissue and tumor. Surprisingly, enhanced antitumor efficacy and autoimmunity was caused by increased function rather than increased numbers of tumor-reactive T cells, as would be expected by homeostatic mechanisms. The gammaC cytokines IL-7 and IL-15 were required for augmenting T cell functionality and antitumor activity. Removal of gammaC cytokine-responsive endogenous cells using antibody or genetic means resulted in the enhanced antitumor responses similar to those seen after nonmyeloablative conditioning. These data indicate that lymphodepletion removes endogenous cellular elements that act as sinks for cytokines that are capable of augmenting the activity of self/tumor-reactive CD8+ T cells. Thus, the restricted availability of homeostatic cytokines can be a contributing factor to peripheral tolerance, as well as a limiting resource for the effectiveness of tumor-specific T cells.

Nonmyeloablative allogeneic immunotherapy for solid tumors.
Richard W Childs, John Barrett.
Annu Rev Med, 2004 Jan 30; 55. PMID: 14746531
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes.
Mark E Dudley, John R Wunderlich, +16 authors, Steven A Rosenberg.
Science, 2002 Sep 21; 298(5594). PMID: 12242449    Free PMC article.
Highly Cited.
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J Curiel, George Coukos, +18 authors, Weiping Zou.
Nat Med, 2004 Aug 24; 10(9). PMID: 15322536
Highly Cited.
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells.
Mary Jo Turk, José A Guevara-Patiño, +3 authors, Alan N Houghton.
J Exp Med, 2004 Sep 24; 200(6). PMID: 15381730    Free PMC article.
Highly Cited.
Syngeneic adoptive immunotherapy and chemoimmunotherapy of a Friend leukemia: requirement for T cells.
J R Berenson, A B Einstein, A Fefer.
J Immunol, 1975 Jul 11; 115(1). PMID: 1080165
Specificity of adoptive chemoimmunotherapy of established syngeneic tumors.
M A Cheever, P D Greenberg, A Fefer.
J Immunol, 1980 Aug 01; 125(2). PMID: 6156213
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.
R J North.
J Exp Med, 1982 Apr 01; 155(4). PMID: 6460831    Free PMC article.
Highly Cited.
Vaccine-stimulated, adoptively transferred CD8+ T cells traffic indiscriminately and ubiquitously while mediating specific tumor destruction.
Douglas C Palmer, Sanjeeve Balasubramaniam, +10 authors, Nicholas P Restifo.
J Immunol, 2004 Dec 09; 173(12). PMID: 15585842    Free PMC article.
In vivo survival and homeostatic proliferation of natural killer cells.
Martin Prlic, Bruce R Blazar, Michael A Farrar, Stephen C Jameson.
J Exp Med, 2003 Apr 16; 197(8). PMID: 12695488    Free PMC article.
Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice.
Rima Koka, Patrick R Burkett, +5 authors, Averil Ma.
J Exp Med, 2003 Apr 16; 197(8). PMID: 12695489    Free PMC article.
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.
Willem W Overwijk, Marc R Theoret, +15 authors, Nicholas P Restifo.
J Exp Med, 2003 Aug 20; 198(4). PMID: 12925674    Free PMC article.
Highly Cited.
Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy.
Helen Y Wang, Dean A Lee, +5 authors, Rong Fu Wang.
Immunity, 2004 Jan 24; 20(1). PMID: 14738769
Highly Cited.
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Paul A Antony, Ciriaco A Piccirillo, +9 authors, Nicholas P Restifo.
J Immunol, 2005 Feb 25; 174(5). PMID: 15728465    Free PMC article.
Highly Cited.
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
Luca Gattinoni, Christopher A Klebanoff, +7 authors, Nicholas P Restifo.
J Clin Invest, 2005 Jun 03; 115(6). PMID: 15931392    Free PMC article.
Highly Cited.
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.
J Shimizu, S Yamazaki, S Sakaguchi.
J Immunol, 1999 Nov 24; 163(10). PMID: 10553041
Highly Cited.
Cutting edge: naive T cells masquerading as memory cells.
K Murali-Krishna, R Ahmed.
J Immunol, 2000 Aug 05; 165(4). PMID: 10925249
Highly Cited.
T cells compete for access to antigen-bearing antigen-presenting cells.
R M Kedl, W A Rees, +4 authors, P Marrack.
J Exp Med, 2000 Oct 18; 192(8). PMID: 11034600    Free PMC article.
Highly Cited.
Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation.
A W Goldrath, L Y Bogatzki, M J Bevan.
J Exp Med, 2000 Aug 22; 192(4). PMID: 10952725    Free PMC article.
Highly Cited.
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells.
B K Cho, V P Rao, +2 authors, J Chen.
J Exp Med, 2000 Aug 22; 192(4). PMID: 10952724    Free PMC article.
Highly Cited.
Autologous regulation of naive T cell homeostasis within the T cell compartment.
W Dummer, B Ernst, +2 authors, C Surh.
J Immunol, 2001 Feb 13; 166(4). PMID: 11160306
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.
K S Schluns, W C Kieper, S C Jameson, L Lefrançois.
Nat Immunol, 2001 Mar 23; 1(5). PMID: 11062503
Highly Cited.
Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation.
Edward Y Woo, Heidi Yeh, +5 authors, Carl H June.
J Immunol, 2002 Apr 24; 168(9). PMID: 11970966
Highly Cited.
Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells.
Ananda W Goldrath, Pallavur V Sivakumar, +5 authors, Eric A Butz.
J Exp Med, 2002 Jun 19; 195(12). PMID: 12070279    Free PMC article.
Highly Cited.
Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells.
Joyce T Tan, Bettina Ernst, +3 authors, Charles D Surh.
J Exp Med, 2002 Jun 19; 195(12). PMID: 12070280    Free PMC article.
Highly Cited.
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells.
Todd C Becker, E John Wherry, +4 authors, Rafi Ahmed.
J Exp Med, 2002 Jun 19; 195(12). PMID: 12070282    Free PMC article.
Highly Cited.
T cell homeostatic proliferation elicits effective antitumor autoimmunity.
Wolfgang Dummer, Andreas G Niethammer, +4 authors, Argyrios N Theofilopoulos.
J Clin Invest, 2002 Jul 18; 110(2). PMID: 12122110    Free PMC article.
Highly Cited.
Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells.
Adam D Judge, Xiaohong Zhang, +2 authors, Jonathan Sprent.
J Exp Med, 2002 Oct 09; 196(7). PMID: 12370255    Free PMC article.
Highly Cited.
Ligands for L-selectin: homing, inflammation, and beyond.
Steven D Rosen.
Annu Rev Immunol, 2004 Mar 23; 22. PMID: 15032576
Highly Cited. Review.
Comment on "Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma".
Masoud H Manjili, Maciej Kmieciak, Johanna Keeler.
J Immunol, 2006 Apr 06; 176(8). PMID: 16585536    Free PMC article.
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.
Paul A Antony, Chrystal M Paulos, +9 authors, Nicholas P Restifo.
J Immunol, 2006 Apr 20; 176(9). PMID: 16621991    Free PMC article.
Adoptive immunotherapy for cancer: building on success.
Luca Gattinoni, Daniel J Powell, Steven A Rosenberg, Nicholas P Restifo.
Nat Rev Immunol, 2006 Apr 20; 6(5). PMID: 16622476    Free PMC article.
Highly Cited. Review.
CD8+ T-cell memory in tumor immunology and immunotherapy.
Christopher A Klebanoff, Luca Gattinoni, Nicholas P Restifo.
Immunol Rev, 2006 Jul 11; 211. PMID: 16824130    Free PMC article.
Highly Cited. Review.
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.
Luca Gattinoni, Anju Ranganathan, +6 authors, Nicholas P Restifo.
Blood, 2006 Aug 03; 108(12). PMID: 16882704    Free PMC article.
Cancer regression in patients after transfer of genetically engineered lymphocytes.
Richard A Morgan, Mark E Dudley, +13 authors, Steven A Rosenberg.
Science, 2006 Sep 02; 314(5796). PMID: 16946036    Free PMC article.
Highly Cited.
Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion.
Daniel J Powell, Mark E Dudley, +2 authors, Steven A Rosenberg.
J Immunol, 2006 Oct 24; 177(9). PMID: 17056585    Free PMC article.
Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?
Pawel Muranski, Andrea Boni, +4 authors, Nicholas P Restifo.
Nat Clin Pract Oncol, 2006 Dec 02; 3(12). PMID: 17139318    Free PMC article.
Highly Cited. Review.
To ablate or not to ablate? HSCs in the T cell driver's seat.
Claudio Anasetti, James J Mulé.
J Clin Invest, 2007 Feb 03; 117(2). PMID: 17273553    Free PMC article.
Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.
Claudia Wrzesinski, Chrystal M Paulos, +5 authors, Nicholas P Restifo.
J Clin Invest, 2007 Feb 03; 117(2). PMID: 17273561    Free PMC article.
CD4 cells can be more efficient at tumor rejection than CD8 cells.
Ainhoa Perez-Diez, Nathalie T Joncker, +4 authors, Polly Matzinger.
Blood, 2007 Mar 01; 109(12). PMID: 17327412    Free PMC article.
Highly Cited.
Vaccination regimens incorporating CpG-containing oligodeoxynucleotides and IL-2 generate antigen-specific antitumor immunity from T-cell populations undergoing homeostatic peripheral expansion after BMT.
James N Kochenderfer, Jessica L Simpson, Christopher D Chien, Ronald E Gress.
Blood, 2007 Mar 21; 110(1). PMID: 17371943    Free PMC article.
Indoleamine 2,3-dioxygenase and tumor-induced tolerance.
David H Munn, Andrew L Mellor.
J Clin Invest, 2007 May 04; 117(5). PMID: 17476344    Free PMC article.
Highly Cited. Review.
Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone.
Jeffrey S Miller, Daniel J Weisdorf, +9 authors, Bruce R Blazar.
Blood, 2007 Jun 21; 110(7). PMID: 17579184    Free PMC article.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.
Mikael J Pittet, Jan Grimm, +6 authors, Ralph Weissleder.
Proc Natl Acad Sci U S A, 2007 Jul 21; 104(30). PMID: 17640914    Free PMC article.
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.
Chrystal M Paulos, Claudia Wrzesinski, +11 authors, Nicholas P Restifo.
J Clin Invest, 2007 Jul 28; 117(8). PMID: 17657310    Free PMC article.
Highly Cited.
Toll-like receptors in tumor immunotherapy.
Chrystal M Paulos, Andrew Kaiser, +11 authors, Nicholas P Restifo.
Clin Cancer Res, 2007 Sep 19; 13(18 Pt 1). PMID: 17875756    Free PMC article.
Immunotherapy and immunoescape in colorectal cancer.
Guillermo Mazzolini, Oihana Murillo, +10 authors, Ignacio Melero.
World J Gastroenterol, 2007 Nov 09; 13(44). PMID: 17990348    Free PMC article.
Rapid accumulation of adoptively transferred CD8+ T cells at the tumor site is associated with long-term control of SV40 T antigen-induced tumors.
Jodi L Yorty, Satvir S Tevethia, Todd D Schell.
Cancer Immunol Immunother, 2007 Nov 16; 57(6). PMID: 18004562    Free PMC article.
T cell immune reconstitution following lymphodepletion.
Kirsten M Williams, Frances T Hakim, Ronald E Gress.
Semin Immunol, 2007 Nov 21; 19(5). PMID: 18023361    Free PMC article.
Highly Cited. Review.
Escape from suppression: tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation.
Paria Mirmonsef, Gladys Tan, +4 authors, Hyam I Levitsky.
Blood, 2007 Dec 08; 111(4). PMID: 18063750    Free PMC article.
Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study.
Amy B Heimberger, Wei Sun, +11 authors, John H Sampson.
Neuro Oncol, 2007 Dec 15; 10(1). PMID: 18079360    Free PMC article.
T-cell receptor gene therapy of established tumors in a murine melanoma model.
John D Abad, Claudia Wrzensinski, +12 authors, Richard A Morgan.
J Immunother, 2007 Dec 25; 31(1). PMID: 18157006    Free PMC article.
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain.
Robert M Prins, Chengyi J Shu, +9 authors, Linda M Liau.
Cancer Immunol Immunother, 2008 Feb 07; 57(9). PMID: 18253732    Free PMC article.
CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.
Thomas Calzascia, Marc Pellegrini, +5 authors, Tak W Mak.
Proc Natl Acad Sci U S A, 2008 Feb 22; 105(8). PMID: 18287017    Free PMC article.
Quantitative analysis of T cell homeostatic proliferation.
Cheng-Rui Li, Sharon Santoso, David D Lo.
Cell Immunol, 2008 Mar 04; 250(1-2). PMID: 18313651    Free PMC article.
Adoptive cell transfer: a clinical path to effective cancer immunotherapy.
Steven A Rosenberg, Nicholas P Restifo, +2 authors, Mark E Dudley.
Nat Rev Cancer, 2008 Mar 21; 8(4). PMID: 18354418    Free PMC article.
Highly Cited. Review.
Identification of HLA-A2 restricted T-cell epitopes within the conserved region of the immunoglobulin G heavy-chain in patients with multiple myeloma.
Sebastian Belle, Fang Han, +12 authors, Michael Hundemer.
Eur J Haematol, 2008 Mar 28; 81(1). PMID: 18363871    Free PMC article.
Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy.
Seagal Teitz-Tennenbaum, Qiao Li, +6 authors, Alfred E Chang.
J Immunother, 2008 Apr 09; 31(4). PMID: 18391761    Free PMC article.
The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells.
Heather J Symons, Moshe Y Levy, +6 authors, Ephraim J Fuchs.
Biol Blood Marrow Transplant, 2008 Apr 16; 14(5). PMID: 18410892    Free PMC article.
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.
Bianca Heemskerk, Ke Liu, +9 authors, Steven A Rosenberg.
Hum Gene Ther, 2008 May 01; 19(5). PMID: 18444786    Free PMC article.
The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease.
Halima Moncrieffe, Mark Coles, Brigitta Stockinger.
Immunology, 2008 May 24; 125(4). PMID: 18498346    Free PMC article.
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.
Douglas C Palmer, Chi-Chao Chan, +11 authors, Nicholas P Restifo.
Proc Natl Acad Sci U S A, 2008 Jun 05; 105(23). PMID: 18523011    Free PMC article.
The anticancer immune response: indispensable for therapeutic success?
Laurence Zitvogel, Lionel Apetoh, +3 authors, Guido Kroemer.
J Clin Invest, 2008 Jun 05; 118(6). PMID: 18523649    Free PMC article.
Highly Cited. Review.
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers.
Africa Wallace, Veena Kapoor, +7 authors, Steven M Albelda.
Clin Cancer Res, 2008 Jun 19; 14(12). PMID: 18559619    Free PMC article.
Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway.
Jacopo Mariotti, Jason Foley, +4 authors, Daniel H Fowler.
Blood, 2008 Jul 16; 112(12). PMID: 18625883    Free PMC article.
Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.
Jason E Foley, Jacopo Mariotti, +2 authors, Daniel H Fowler.
Biol Blood Marrow Transplant, 2008 Aug 30; 14(9). PMID: 18721759    Free PMC article.
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.
Sergio A Quezada, Karl S Peggs, +3 authors, James P Allison.
J Exp Med, 2008 Aug 30; 205(9). PMID: 18725522    Free PMC article.
Highly Cited.
Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges.
James W Hodge, Chandan Guha, Jacques Neefjes, James L Gulley.
Oncology (Williston Park), 2008 Sep 10; 22(9). PMID: 18777956    Free PMC article.
Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantation.
Katayoun Rezvani, A John Barrett.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790448    Free PMC article.
Use of natural killer cells as immunotherapy for leukaemia.
Bartosz Grzywacz, Jeffrey S Miller, Michael R Verneris.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790450    Free PMC article.
Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation.
Kirsten M Williams, Ronald E Gress.
Best Pract Res Clin Haematol, 2008 Sep 16; 21(3). PMID: 18790456    Free PMC article.
Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.
Andrea Boni, Pawel Muranski, +8 authors, Nicholas P Restifo.
Blood, 2008 Sep 19; 112(12). PMID: 18799724    Free PMC article.
Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
Mark E Dudley, James C Yang, +17 authors, Steven A Rosenberg.
J Clin Oncol, 2008 Sep 24; 26(32). PMID: 18809613    Free PMC article.
Highly Cited.
Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy.
Grégory Verdeil, Kristi Marquardt, Charles D Surh, Linda A Sherman.
Proc Natl Acad Sci U S A, 2008 Oct 22; 105(43). PMID: 18936481    Free PMC article.
Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells.
Andrzej Wierzbicki, Margaret Gil, +5 authors, Danuta Kozbor.
J Immunol, 2008 Oct 23; 181(9). PMID: 18941255    Free PMC article.
Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients.
Chrystal U Louis, Karin Straathof, +10 authors, Stephen Gottschalk.
Blood, 2008 Oct 31; 113(11). PMID: 18971421    Free PMC article.
Dysfunctional DC subsets in RCC patients: ex vivo correction to yield an effective anti-cancer vaccine.
M Gigante, A Blasi, +9 authors, E Ranieri.
Mol Immunol, 2008 Dec 02; 46(5). PMID: 19041139    Free PMC article.
Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory.
Weiqing Jing, Jill A Gershan, Bryon D Johnson.
Blood, 2009 Feb 03; 113(18). PMID: 19182203    Free PMC article.
Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C).
Mohamed L Salem, C Marcela Díaz-Montero, +5 authors, David J Cole.
J Immunol, 2009 Feb 10; 182(4). PMID: 19201856    Free PMC article.
Use of tumour-responsive T cells as cancer treatment.
Mary L Disis, Helga Bernhard, Elizabeth M Jaffee.
Lancet, 2009 Feb 24; 373(9664). PMID: 19231634    Free PMC article.
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.
Juan F Vera, Valentina Hoyos, +9 authors, Gianpietro Dotti.
Mol Ther, 2009 Mar 05; 17(5). PMID: 19259067    Free PMC article.
Harnessing innate and adaptive immunity for adoptive cell therapy of renal cell carcinoma.
Christiane Geiger, Elfriede Nössner, +3 authors, Dolores J Schendel.
J Mol Med (Berl), 2009 Mar 10; 87(6). PMID: 19271159
Adoptive cell therapy for the treatment of patients with metastatic melanoma.
Steven A Rosenberg, Mark E Dudley.
Curr Opin Immunol, 2009 Mar 24; 21(2). PMID: 19304471    Free PMC article.
Highly Cited. Review.
Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity.
Claudio G Brunstein, John E Wagner, +7 authors, Jeffrey S Miller.
Blood, 2009 Mar 31; 113(22). PMID: 19329778    Free PMC article.
Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.
Gabrielle A Rizzuto, Taha Merghoub, +9 authors, Alan N Houghton.
J Exp Med, 2009 Apr 01; 206(4). PMID: 19332877    Free PMC article.
Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis.
Manoj Saini, Claire Pearson, Benedict Seddon.
Blood, 2009 Apr 10; 113(23). PMID: 19357399    Free PMC article.
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Marc Pellegrini, Thomas Calzascia, +12 authors, Tak W Mak.
Nat Med, 2009 Apr 28; 15(5). PMID: 19396174
Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer.
Seagal Teitz-Tennenbaum, Qiao Li, +4 authors, Alfred E Chang.
J Immunother, 2009 Jun 02; 32(6). PMID: 19483649    Free PMC article.
Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.
Christopher A Klebanoff, Zhiya Yu, +3 authors, Nicholas P Restifo.
Blood, 2009 Jun 30; 114(9). PMID: 19561320    Free PMC article.
Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor.
James N Kochenderfer, Steven A Feldman, +5 authors, Steven A Rosenberg.
J Immunother, 2009 Jun 30; 32(7). PMID: 19561539    Free PMC article.
Highly Cited.
Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination.
Vedran Radojcic, Karl B Bezak, +4 authors, Leo Luznik.
Cancer Immunol Immunother, 2009 Jul 11; 59(1). PMID: 19590872    Free PMC article.
The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients.
Amy B Heimberger, John H Sampson.
Expert Opin Biol Ther, 2009 Jul 14; 9(8). PMID: 19591631    Free PMC article.
CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion.
Yolanda Nesbeth, Uciane Scarlett, +4 authors, Jose R Conejo-Garcia.
Cancer Res, 2009 Jul 16; 69(15). PMID: 19602595    Free PMC article.
Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity.
Amorette Barber, Charles L Sentman.
J Immunol, 2009 Jul 25; 183(4). PMID: 19625653    Free PMC article.
In vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy.
Qiao Li, Seagal Teitz-Tennenbaum, +2 authors, Alfred E Chang.
J Immunol, 2009 Aug 12; 183(5). PMID: 19667089    Free PMC article.
T-cell seeding: neonatal transfer of anti-myelin basic protein T-cell lines renders Fischer rats susceptible later in life to the active induction of experimental autoimmune encephalitis.
Ilan Volovitz, Felix Mor, +6 authors, Irun Cohen.
Immunology, 2009 Aug 20; 128(1). PMID: 19689739    Free PMC article.
Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?".
Gianpietro Dotti, Barbara Savoldo, Malcolm Brenner.
Hum Gene Ther, 2009 Aug 26; 20(11). PMID: 19702437    Free PMC article.
Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts.
Yongzhi Cui, Hua Zhang, +3 authors, Crystal L Mackall.
Blood, 2009 Aug 26; 114(18). PMID: 19704119    Free PMC article.
Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation.
Vincent T Ho, Matthew Vanneman, +14 authors, Robert Soiffer.
Proc Natl Acad Sci U S A, 2009 Sep 01; 106(37). PMID: 19717467    Free PMC article.
Treatment of lymphoma with adoptively transferred T cells.
Brian G Till, Oliver W Press.
Expert Opin Biol Ther, 2009 Sep 03; 9(11). PMID: 19723016    Free PMC article.
Depletion of tumor-induced Treg prior to reconstitution rescues enhanced priming of tumor-specific, therapeutic effector T cells in lymphopenic hosts.
Christian H Poehlein, Daniel P Haley, Edwin B Walker, Bernard A Fox.
Eur J Immunol, 2009 Oct 20; 39(11). PMID: 19839008    Free PMC article.
A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy.
Cameron J Turtle, Hillary M Swanson, +2 authors, Stanley R Riddell.
Immunity, 2009 Nov 03; 31(5). PMID: 19879163    Free PMC article.
Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.
Douglas C Palmer, Nicholas P Restifo.
Trends Immunol, 2009 Nov 03; 30(12). PMID: 19879803    Free PMC article.
Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice.
Scott E James, Nural N Orgun, +5 authors, Oliver W Press.
Blood, 2009 Nov 03; 114(27). PMID: 19880489    Free PMC article.
Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination.
Mohamed Labib Salem, David J Cole.
Cancer Immunol Immunother, 2009 Nov 19; 59(3). PMID: 19921513    Free PMC article.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
William Humphries, Jun Wei, John H Sampson, Amy B Heimberger.
Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972    Free PMC article.
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.
Claudia Wrzesinski, Chrystal M Paulos, +6 authors, Nicholas P Restifo.
J Immunother, 2009 Dec 03; 33(1). PMID: 19952961    Free PMC article.
Highly Cited.
Increased plasma-immune cytokines throughout the high-dose melphalan-induced lymphodepletion in patients with multiple myeloma: a window for adoptive immunotherapy.
Maud Condomines, Jean-Luc Veyrune, +7 authors, Bernard Klein.
J Immunol, 2009 Dec 08; 184(2). PMID: 19966210    Free PMC article.
Biology and clinical effects of natural killer cells in allogeneic transplantation.
Jonathan E Benjamin, Saar Gill, Robert S Negrin.
Curr Opin Oncol, 2009 Dec 17; 22(2). PMID: 20010294    Free PMC article.
Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo.
Mohamed L Salem, Sabry A El-Naggar, David J Cole.
Cell Immunol, 2009 Dec 29; 261(2). PMID: 20036354    Free PMC article.
Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells.
Mohamed L Salem, Amir A Al-Khami, +3 authors, David J Cole.
J Immunol, 2010 Jan 20; 184(4). PMID: 20083664    Free PMC article.
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
Sergio A Quezada, Tyler R Simpson, +9 authors, James P Allison.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156971    Free PMC article.
Highly Cited.
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
Ying Xie, Akgül Akpinarli, +6 authors, Paul Andrew Antony.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156973    Free PMC article.
Highly Cited.
CD122+CD8+ Treg suppress vaccine-induced antitumor immune responses in lymphodepleted mice.
Li-Xin Wang, Yuhuan Li, +5 authors, Hong-Ming Hu.
Eur J Immunol, 2010 Feb 27; 40(5). PMID: 20186876    Free PMC article.
Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma.
Shari Pilon-Thomas, Amy Mackay, Nasreen Vohra, James J Mulé.
J Immunol, 2010 Mar 03; 184(7). PMID: 20194714    Free PMC article.
Redirecting the immune response: role of adoptive T cell therapy.
Anna Mondino, Valérie Dardalhon, +2 authors, Naomi Taylor.
Hum Gene Ther, 2010 Mar 06; 21(5). PMID: 20201627    Free PMC article.
JAK3/STAT5/6 pathway alterations are associated with immune deviation in CD8 T cells in renal cell carcinoma patients.
Elisabetta Cavalcanti, Margherita Gigante, +9 authors, Elena Ranieri.
J Biomed Biotechnol, 2010 Mar 27; 2010. PMID: 20339477    Free PMC article.
Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression.
Theresa L Whiteside.
Expert Opin Biol Ther, 2010 Apr 27; 10(7). PMID: 20415597    Free PMC article.
Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells.
James N Kochenderfer, Zhiya Yu, +2 authors, Steven A Rosenberg.
Blood, 2010 Jul 16; 116(19). PMID: 20631379    Free PMC article.
Highly Cited.
Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects.
Myriam N Bouchlaka, Doug Redelman, William J Murphy.
Immunotherapy, 2010 Jul 20; 2(3). PMID: 20635904    Free PMC article.
Lymphoma immunotherapy: vaccines, adoptive cell transfer and immunotransplant.
Joshua Brody, Ronald Levy.
Immunotherapy, 2010 Jul 20; 1(5). PMID: 20636025    Free PMC article.
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.
Sid P Kerkar, Pawel Muranski, +12 authors, Nicholas P Restifo.
Cancer Res, 2010 Jul 22; 70(17). PMID: 20647327    Free PMC article.
Highly Cited.
Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.
Lis R V Antonelli, Yolanda Mahnke, +9 authors, Irini Sereti.
Blood, 2010 Jul 28; 116(19). PMID: 20660788    Free PMC article.
CD8+ enriched "young" tumor infiltrating lymphocytes can mediate regression of metastatic melanoma.
Mark E Dudley, Colin A Gross, +17 authors, Steven A Rosenberg.
Clin Cancer Res, 2010 Jul 30; 16(24). PMID: 20668005    Free PMC article.
Amplifying TLR-MyD88 signals within tumor-specific T cells enhances antitumor activity to suboptimal levels of weakly immunogenic tumor antigens.
Degui Geng, Liqin Zheng, +4 authors, Eduardo Davila.
Cancer Res, 2010 Sep 03; 70(19). PMID: 20807806    Free PMC article.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.
Christian S Hinrichs, Zachary A Borman, +14 authors, Nicholas P Restifo.
Blood, 2010 Oct 26; 117(3). PMID: 20971955    Free PMC article.
Highly Cited.
Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice.
Dhanalakshmi Chinnasamy, Zhiya Yu, +6 authors, Steven A Rosenberg.
J Clin Invest, 2010 Oct 28; 120(11). PMID: 20978347    Free PMC article.
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells.
Wolfgang Koestner, Martin Hapke, +9 authors, Martin G Sauer.
Blood, 2010 Nov 11; 117(3). PMID: 21063028    Free PMC article.
Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.
Yolanda Nesbeth, Jose R Conejo-Garcia.
Clin Dev Immunol, 2010 Nov 16; 2010. PMID: 21076522    Free PMC article.
Immunotherapy for ovarian cancer: what's next?
Lana E Kandalaft, Daniel J Powell, Nathan Singh, George Coukos.
J Clin Oncol, 2010 Nov 17; 29(7). PMID: 21079136    Free PMC article.
Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.
Sung P Ha, Nicholas D Klemen, +8 authors, Christopher E Touloukian.
J Clin Invest, 2010 Nov 19; 120(12). PMID: 21084750    Free PMC article.
Adoptive cell therapy of prostate cancer using female mice-derived T cells that react with prostate antigens.
Huanfa Yi, Xiaofei Yu, +3 authors, Xiang-Yang Wang.
Cancer Immunol Immunother, 2010 Nov 23; 60(3). PMID: 21088965    Free PMC article.
Therapeutic cancer vaccines: are we there yet?
Christopher A Klebanoff, Nicolas Acquavella, Zhiya Yu, Nicholas P Restifo.
Immunol Rev, 2011 Jan 05; 239(1). PMID: 21198663    Free PMC article.
Highly Cited. Review.
Treatment of multiple myeloma with adoptively transferred chimeric NKG2D receptor-expressing T cells.
A Barber, K R Meehan, C L Sentman.
Gene Ther, 2011 Jan 07; 18(5). PMID: 21209626    Free PMC article.
T cell-tumor interaction directs the development of immunotherapies in head and neck cancer.
A E Albers, L Strauss, +2 authors, A M Kaufmann.
Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234340    Free PMC article.
Focus on adoptive T cell transfer trials in melanoma.
Liat Hershkovitz, Jacob Schachter, Avraham J Treves, Michal J Besser.
Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234353    Free PMC article.
Contribution of the immune system to the chemotherapeutic response.
Alison M McDonnell, Anna K Nowak, Richard A Lake.
Semin Immunopathol, 2011 Jan 29; 33(4). PMID: 21274535
Activating systemic T-cell immunity against self tumor antigens to support oncolytic virotherapy with vesicular stomatitis virus.
Phonphimon Wongthida, Rosa Maria Diaz, +7 authors, Richard Vile.
Hum Gene Ther, 2011 Mar 04; 22(11). PMID: 21366404    Free PMC article.
Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients.
Steven E Finkelstein, Cristina Iclozan, +15 authors, Dmitry I Gabrilovich.
Int J Radiat Oncol Biol Phys, 2011 Mar 15; 82(2). PMID: 21398051    Free PMC article.
Ex vivo gene transfer and correction for cell-based therapies.
Luigi Naldini.
Nat Rev Genet, 2011 Mar 30; 12(5). PMID: 21445084
Highly Cited. Review.
Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy.
Carlos A Ramos, Gianpietro Dotti.
Expert Opin Biol Ther, 2011 Apr 06; 11(7). PMID: 21463133    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Steven A Rosenberg, James C Yang, +12 authors, Mark E Dudley.
Clin Cancer Res, 2011 Apr 19; 17(13). PMID: 21498393    Free PMC article.
Highly Cited.
Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro.
Jianping Huang, Qiong J Wang, +4 authors, Paul F Robbins.
J Immunother, 2011 Apr 19; 34(4). PMID: 21499130    Free PMC article.
Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells.
Marcus O Butler, Philip Friedlander, +19 authors, Naoto Hirano.
Sci Transl Med, 2011 Apr 29; 3(80). PMID: 21525398    Free PMC article.
Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy.
S Merims, X Li, +7 authors, L Zhang.
Leukemia, 2011 May 14; 25(9). PMID: 21566657    Free PMC article.
Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression.
Qiao Li, Xiangming Lao, +5 authors, Alfred E Chang.
Clin Cancer Res, 2011 Jun 22; 17(15). PMID: 21690573    Free PMC article.
Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice.
Christopher A Klebanoff, Luca Gattinoni, +9 authors, Nicholas P Restifo.
Clin Cancer Res, 2011 Jul 09; 17(16). PMID: 21737507    Free PMC article.
Highly Cited.
Anti-tumor immune responses in immune-reconstituted mice injected with a tumor vaccine.
Aili He, Wanggang Zhang, +3 authors, Xingmei Chao.
Med Oncol, 2011 Jul 16; 29(3). PMID: 21761245
Engineered T cells for the adoptive therapy of B-cell chronic lymphocytic leukaemia.
Philipp Koehler, Patrick Schmidt, +2 authors, Hinrich Abken.
Adv Hematol, 2011 Aug 13; 2012. PMID: 21837241    Free PMC article.
Chronic chemoimmunotherapy achieves cure of spontaneous murine mammary tumors via persistent blockade of posttherapy counter-regulation.
Rachael B Rowswell-Turner, Jamie L Harden, +3 authors, Nejat K Egilmez.
J Immunol, 2011 Sep 13; 187(8). PMID: 21908736    Free PMC article.
Synergy of brief activation of CD8 T-cells in the presence of IL-12 and adoptive transfer into lymphopenic hosts promotes tumor clearance and anti-tumor memory.
C Marcela Díaz-Montero, Osama Naga, +9 authors, Mathias G Lichtenheld.
Am J Cancer Res, 2011 Sep 15; 1(7). PMID: 21915391    Free PMC article.
Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation.
Allison L Bayer, Jackeline Chirinos, +4 authors, Robert B Levy.
Eur J Immunol, 2011 Sep 20; 41(12). PMID: 21928285    Free PMC article.
Multiple vaccinations: friend or foe.
Sarah E Church, Shawn M Jensen, +4 authors, Bernard A Fox.
Cancer J, 2011 Sep 29; 17(5). PMID: 21952289    Free PMC article.
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.
Anik L Côté, Katelyn T Byrne, +2 authors, Mary Jo Turk.
PLoS One, 2011 Nov 03; 6(10). PMID: 22046294    Free PMC article.
Targeting T cells with bispecific antibodies for cancer therapy.
Lawrence G Lum, Archana Thakur.
BioDrugs, 2011 Nov 05; 25(6). PMID: 22050339    Free PMC article.
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.
Sid P Kerkar, Romina S Goldszmid, +10 authors, Nicholas P Restifo.
J Clin Invest, 2011 Nov 08; 121(12). PMID: 22056381    Free PMC article.
Highly Cited.
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
James N Kochenderfer, Mark E Dudley, +15 authors, Steven A Rosenberg.
Blood, 2011 Dec 14; 119(12). PMID: 22160384    Free PMC article.
Highly Cited.
The confluence of stereotactic ablative radiotherapy and tumor immunology.
Steven Eric Finkelstein, Robert Timmerman, +4 authors, George D Wilson.
Clin Dev Immunol, 2011 Dec 14; 2011. PMID: 22162711    Free PMC article.
Exploitation of the propulsive force of chemotherapy for improving the response to cancer immunotherapy.
Enrico Proietti, Federica Moschella, Imerio Capone, Filippo Belardelli.
Mol Oncol, 2011 Dec 20; 6(1). PMID: 22177803    Free PMC article.
Genetic engineering with T cell receptors.
Ling Zhang, Richard A Morgan.
Adv Drug Deliv Rev, 2011 Dec 20; 64(8). PMID: 22178904    Free PMC article.
Immune microenvironments in solid tumors: new targets for therapy.
Stephen L Shiao, A Preethi Ganesan, Hope S Rugo, Lisa M Coussens.
Genes Dev, 2011 Dec 23; 25(24). PMID: 22190457    Free PMC article.
Highly Cited. Review.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Oana Draghiciu, Hans W Nijman, Toos Daemen.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971    Free PMC article.
Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy.
Katayoun Rezvani, Agnes S M Yong, +8 authors, A John Barrett.
Cancer Immunol Immunother, 2011 Dec 27; 61(7). PMID: 22198310    Free PMC article.
Cancer immunotherapy.
Thomas F Gajewski.
Mol Oncol, 2012 Jan 18; 6(2). PMID: 22248437    Free PMC article.
Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help.
Marcus O Butler, Osamu Imataki, +10 authors, Naoto Hirano.
PLoS One, 2012 Jan 27; 7(1). PMID: 22279573    Free PMC article.
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results.
Brian G Till, Michael C Jensen, +12 authors, Oliver W Press.
Blood, 2012 Feb 07; 119(17). PMID: 22308288    Free PMC article.
Highly Cited.
Adoptive transfer with high-affinity TCR to treat human solid tumors: how to improve the feasibility?
F Jotereau, N Gervois, N Labarrière.
Target Oncol, 2012 Feb 22; 7(1). PMID: 22350487
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.
Hollie J Pegram, James C Lee, +4 authors, Renier J Brentjens.
Blood, 2012 Feb 23; 119(18). PMID: 22354001    Free PMC article.
Highly Cited.
A potent vaccination strategy that circumvents lymphodepletion for effective antitumor adoptive T-cell therapy.
Hyun-Il Cho, Eduardo Reyes-Vargas, Julio C Delgado, Esteban Celis.
Cancer Res, 2012 Mar 01; 72(8). PMID: 22367213    Free PMC article.
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
John H Sampson, Robert J Schmittling, +13 authors, Duane A Mitchell.
PLoS One, 2012 Mar 03; 7(2). PMID: 22383993    Free PMC article.
Cytotoxic chemotherapy and CD4+ effector T cells: an emerging alliance for durable antitumor effects.
Zhi-Chun Ding, Gang Zhou.
Clin Dev Immunol, 2012 Mar 09; 2012. PMID: 22400040    Free PMC article.
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor.
Robert P T Somerville, Laura Devillier, +2 authors, Mark E Dudley.
J Transl Med, 2012 Apr 06; 10. PMID: 22475724    Free PMC article.
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum.
Cristina Bergamaschi, Jenifer Bear, +7 authors, George N Pavlakis.
Blood, 2012 Apr 13; 120(1). PMID: 22496150    Free PMC article.
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide.
Mohamed L Salem, Amir A Al-Khami, +4 authors, David J Cole.
Cell Immunol, 2012 May 09; 276(1-2). PMID: 22560674    Free PMC article.
Emerging concepts in haematopoietic cell transplantation.
Hao Wei Li, Megan Sykes.
Nat Rev Immunol, 2012 May 26; 12(6). PMID: 22627859    Free PMC article.
Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.
Shawn M Jensen, Christopher G Twitty, +6 authors, Bernard A Fox.
J Immunol, 2012 Jun 23; 189(2). PMID: 22723522    Free PMC article.
Adoptive transfer of cytotoxic T lymphocytes targeting two different antigens limits antigen loss and tumor escape.
Karen M Kaluza, Timothy Kottke, +3 authors, Richard Vile.
Hum Gene Ther, 2012 Jun 28; 23(10). PMID: 22734672    Free PMC article.
Trial Watch: Adoptive cell transfer immunotherapy.
Lorenzo Galluzzi, Erika Vacchelli, +6 authors, Guido Kroemer.
Oncoimmunology, 2012 Jun 28; 1(3). PMID: 22737606    Free PMC article.
Neoantigen and tumor antigen-specific immunity transferred from immunized donors is detectable early after allogeneic transplantation in myeloma patients.
M Foglietta, S S Neelapu, +13 authors, M R Bishop.
Bone Marrow Transplant, 2012 Jul 10; 48(2). PMID: 22773122    Free PMC article.
A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model.
Yogesh M Kulkarni, Emily Chambers, +3 authors, David J Klinke.
Integr Biol (Camb), 2012 Jul 11; 4(8). PMID: 22777646    Free PMC article.
Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo.
Ingunn M Stromnes, Carla Fowler, +8 authors, Philip D Greenberg.
J Immunol, 2012 Jul 17; 189(4). PMID: 22798667    Free PMC article.
Current translational and clinical practices in hematopoietic cell and gene therapy.
David L Digiusto, Hans-Peter Kiem.
Cytotherapy, 2012 Jul 18; 14(7). PMID: 22799276    Free PMC article.
A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer.
Lana E Kandalaft, Daniel J Powell, George Coukos.
J Transl Med, 2012 Aug 07; 10. PMID: 22863016    Free PMC article.
Adoptive immunotherapy of advanced melanoma.
Ronnie Shapira-Frommer, Jacob Schachter.
Curr Treat Options Oncol, 2012 Aug 07; 13(3). PMID: 22864561
Tumor-infiltrating lymphocytes in melanoma.
Sylvia Lee, Kim Margolin.
Curr Oncol Rep, 2012 Aug 11; 14(5). PMID: 22878966    Free PMC article.
Adoptive transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of total body irradiation eradicates breast tumors.
Nadine M Lerret, Magdalena Rogozinska, Andrés Jaramillo, Amanda L Marzo.
PLoS One, 2012 Aug 23; 7(7). PMID: 22911764    Free PMC article.
A pharmacologic perspective on newly emerging T-cell manipulation technologies.
Dominic Smethurst.
Br J Clin Pharmacol, 2012 Oct 09; 76(2). PMID: 23039307    Free PMC article.
Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras.
Hui Wang, Yanping Yang, +4 authors, Yong-Guang Yang.
PLoS One, 2012 Oct 19; 7(10). PMID: 23077554    Free PMC article.
Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale.
Xiuli Wang, Araceli Naranjo, +8 authors, Michael C Jensen.
J Immunother, 2012 Oct 24; 35(9). PMID: 23090078    Free PMC article.
The past, present, and future of adoptive T cell therapy.
Donghoon Choi, Tai-Gyu Kim, Young Chul Sung.
Immune Netw, 2012 Oct 24; 12(4). PMID: 23091437    Free PMC article.
Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma.
Krithika N Kodumudi, Amy Weber, Amod A Sarnaik, Shari Pilon-Thomas.
J Immunol, 2012 Oct 27; 189(11). PMID: 23100512    Free PMC article.
Nonalloreactive T cells prevent donor lymphocyte infusion-induced graft-versus-host disease by controlling microbial stimuli.
Hao Wei Li, Jessica Sachs, +3 authors, Megan Sykes.
J Immunol, 2012 Nov 09; 189(12). PMID: 23136200    Free PMC article.
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
Jing Ni, Matthias Miller, +2 authors, Adelheid Cerwenka.
J Exp Med, 2012 Dec 05; 209(13). PMID: 23209317    Free PMC article.
Highly Cited.
Clinical opportunities in combining immunotherapy with radiation therapy.
Steven E Finkelstein, Mayer Fishman.
Front Oncol, 2012 Dec 13; 2. PMID: 23233905    Free PMC article.
Radiation-induced effects and the immune system in cancer.
Punit Kaur, Alexzander Asea.
Front Oncol, 2012 Dec 20; 2. PMID: 23251903    Free PMC article.
Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation.
Mohamed-Rachid Boulassel, Ahmed Galal.
Sultan Qaboos Univ Med J, 2012 Dec 28; 12(3). PMID: 23269948    Free PMC article.
Effects of tumor irradiation on host T-regulatory cells and systemic immunity in the context of adoptive T-cell therapy in mice.
Shuang Wei, Martin U Egenti, +2 authors, Alfred E Chang.
J Immunother, 2013 Feb 05; 36(2). PMID: 23377667    Free PMC article.
Adoptive T-cell transfer combined with a single low dose of total body irradiation eradicates breast tumors.
Nadine M Lerret, Amanda L Marzo.
Oncoimmunology, 2013 Mar 26; 2(2). PMID: 23525138    Free PMC article.
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
Luis A Sanchez-Perez, Bryan D Choi, +9 authors, John H Sampson.
PLoS One, 2013 Mar 26; 8(3). PMID: 23527092    Free PMC article.
Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors.
James N Kochenderfer, Steven A Rosenberg.
Nat Rev Clin Oncol, 2013 Apr 03; 10(5). PMID: 23546520    Free PMC article.
Highly Cited. Review.
BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide.
Luis Sanchez-Perez, Bryan D Choi, +9 authors, John H Sampson.
Cancer Immunol Immunother, 2013 Apr 18; 62(6). PMID: 23591978    Free PMC article.
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Boris Engels, Victor H Engelhard, +7 authors, Hans Schreiber.
Cancer Cell, 2013 Apr 20; 23(4). PMID: 23597565    Free PMC article.
Chemotherapy in the management of advanced cutaneous malignant melanoma.
Jason J Luke, Gary K Schwartz.
Clin Dermatol, 2013 Apr 24; 31(3). PMID: 23608448    Free PMC article.
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.
Tyce J Kearl, Weiqing Jing, Jill A Gershan, Bryon D Johnson.
J Immunol, 2013 Apr 26; 190(11). PMID: 23616570    Free PMC article.
Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.
Dhanalakshmi Chinnasamy, Eric Tran, +3 authors, Steven A Rosenberg.
Cancer Res, 2013 May 02; 73(11). PMID: 23633494    Free PMC article.
Cellular immunotherapy for carcinoma using genetically modified EGFR-specific T lymphocytes.
Xikun Zhou, Jing Li, +9 authors, Yu-quan Wei.
Neoplasia, 2013 May 02; 15(5). PMID: 23633926    Free PMC article.
Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors.
Paul Spear, Amorette Barber, Charles L Sentman.
Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734311    Free PMC article.
An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma.
David A Reardon, Kai W Wucherpfennig, +8 authors, Glenn Dranoff.
Expert Rev Vaccines, 2013 Jun 12; 12(6). PMID: 23750791    Free PMC article.
Trial Watch: Adoptive cell transfer for anticancer immunotherapy.
Erika Vacchelli, Alexander Eggermont, +5 authors, Lorenzo Galluzzi.
Oncoimmunology, 2013 Jun 14; 2(5). PMID: 23762803    Free PMC article.
Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges.
Ethan Q Han, Xiu-ling Li, +2 authors, Shuang-yin Han.
J Hematol Oncol, 2013 Jul 09; 6. PMID: 23829929    Free PMC article.
Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells.
Ute E Burkhardt, Ursula Hainz, +28 authors, Catherine J Wu.
J Clin Invest, 2013 Aug 06; 123(9). PMID: 23912587    Free PMC article.
CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor.
Qunrui Ye, De-Gang Song, +5 authors, Daniel J Powell.
Clin Cancer Res, 2013 Sep 21; 20(1). PMID: 24045181    Free PMC article.
Highly Cited.
Innate and adaptive immune cells in the tumor microenvironment.
Thomas F Gajewski, Hans Schreiber, Yang-Xin Fu.
Nat Immunol, 2013 Sep 21; 14(10). PMID: 24048123    Free PMC article.
Highly Cited. Review.
Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation.
James N Kochenderfer, Mark E Dudley, +21 authors, Steven A Rosenberg.
Blood, 2013 Sep 24; 122(25). PMID: 24055823    Free PMC article.
Highly Cited.
Impact of T cell selection methods in the success of clinical adoptive immunotherapy.
Natalia Ramírez, Lorea Beloki, +5 authors, Eduardo Olavarría.
Cell Mol Life Sci, 2013 Oct 01; 71(7). PMID: 24077876
Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells.
Sarah E Church, Shawn M Jensen, +2 authors, Bernard A Fox.
Eur J Immunol, 2013 Oct 12; 44(1). PMID: 24114780    Free PMC article.
Reassessing target antigens for adoptive T-cell therapy.
Christian S Hinrichs, Nicholas P Restifo.
Nat Biotechnol, 2013 Oct 22; 31(11). PMID: 24142051    Free PMC article.
Highly Cited. Review.
Allogeneic stem cell transplantation for patients with advanced rhabdomyosarcoma: a retrospective assessment.
U Thiel, E Koscielniak, +26 authors, Solid Tumour Working Party and the Paediatric Disease Working Party of the European Group for Blood and Marrow Transplantation.
Br J Cancer, 2013 Oct 24; 109(10). PMID: 24149176    Free PMC article.
Tolerance and exhaustion: defining mechanisms of T cell dysfunction.
Andrea Schietinger, Philip D Greenberg.
Trends Immunol, 2013 Nov 12; 35(2). PMID: 24210163    Free PMC article.
Highly Cited. Review.
Immune suppression in tumors as a surmountable obstacle to clinical efficacy of cancer vaccines.
Grégoire Wieërs, Nathalie Demotte, Danièle Godelaine, Pierre Van der Bruggen.
Cancers (Basel), 2011 Jan 01; 3(3). PMID: 24212939    Free PMC article.
Exploiting the curative potential of adoptive T-cell therapy for cancer.
Christian S Hinrichs, Steven A Rosenberg.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329789    Free PMC article.
Highly Cited. Review.
Enhanced responses to tumor immunization following total body irradiation are time-dependent.
Adi Diab, Robert R Jenq, +14 authors, Miguel-Angel Perales.
PLoS One, 2013 Dec 19; 8(12). PMID: 24349298    Free PMC article.
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.
John H Sampson, Bryan D Choi, +12 authors, Laura A Johnson.
Clin Cancer Res, 2013 Dec 20; 20(4). PMID: 24352643    Free PMC article.
Highly Cited.
HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin.
Yalena Amador-Cañizares, Gillian Martínez-Donato, +16 authors, Santiago Dueñas-Carrera.
World J Gastroenterol, 2014 Jan 15; 20(1). PMID: 24415868    Free PMC article.
Adoptive immunotherapy for cancer or viruses.
Marcela V Maus, Joseph A Fraietta, +3 authors, Carl H June.
Annu Rev Immunol, 2014 Jan 16; 32. PMID: 24423116    Free PMC article.
Highly Cited. Review.
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers.
Yong Lu, Bangxing Hong, +5 authors, Qing Yi.
Proc Natl Acad Sci U S A, 2014 Jan 29; 111(6). PMID: 24469818    Free PMC article.
Boosting leukemia-specific T cell responses in patients following stem cell transplantation.
Ute E Burkhardt, Catherine J Wu.
Oncoimmunology, 2014 Feb 01; 2(11). PMID: 24482749    Free PMC article.
Immunotherapy for solid tumors--a review for surgeons.
Abdul Saied, Venu G Pillarisetty, Steven C Katz.
J Surg Res, 2014 Feb 04; 187(2). PMID: 24485876    Free PMC article.
Combined treatment of murine fibrosarcoma with chemotherapy (Paclitaxel), radiotherapy, and intratumoral injection of dendritic cells.
Ji-Won Byun, Hyeon-Sook Lee, +5 authors, Gwang-Seong Choi.
Ann Dermatol, 2014 Mar 22; 26(1). PMID: 24648686    Free PMC article.
Melanoma immunotherapy.
Martina Sanlorenzo, Igor Vujic, +10 authors, Susanna Ortiz-Urda.
Cancer Biol Ther, 2014 Mar 22; 15(6). PMID: 24651672    Free PMC article.
CD19-CAR trials.
Carlos A Ramos, Barbara Savoldo, Gianpietro Dotti.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667955    Free PMC article.
MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial.
Emanuela Romano, Olivier Michielin, +8 authors, Alexandre Harari.
J Transl Med, 2014 Apr 15; 12. PMID: 24726012    Free PMC article.
Cell transfer therapy for cancer: past, present, and future.
Xiaoling Qian, Xian Wang, Hongchuan Jin.
J Immunol Res, 2014 Apr 18; 2014. PMID: 24741604    Free PMC article.
Whole-body irradiation increases the magnitude and persistence of adoptively transferred T cells associated with tumor regression in a mouse model of prostate cancer.
Lindsay K Ward-Kavanagh, Junjia Zhu, Timothy K Cooper, Todd D Schell.
Cancer Immunol Res, 2014 May 08; 2(8). PMID: 24801834    Free PMC article.
Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing.
Yun Ji, Natalie Abrams, +9 authors, Nicholas P Restifo.
PLoS One, 2014 May 16; 9(5). PMID: 24827921    Free PMC article.
Cancer-testis antigen 7 expression and immune responses following allogeneic stem cell transplantation for multiple myeloma.
Eleanor M Tyler, Achim A Jungbluth, +2 authors, Guenther Koehne.
Cancer Immunol Res, 2014 Jun 05; 2(6). PMID: 24894092    Free PMC article.
Early donor chimerism levels predict relapse and survival after allogeneic stem cell transplantation with reduced-intensity conditioning.
Ran Reshef, Elizabeth O Hexner, +11 authors, David L Porter.
Biol Blood Marrow Transplant, 2014 Jul 13; 20(11). PMID: 25016197    Free PMC article.
Trial Watch: Adoptive cell transfer for anticancer immunotherapy.
Fernando Aranda, Erika Vacchelli, +8 authors, Lorenzo Galluzzi.
Oncoimmunology, 2014 Jul 23; 3. PMID: 25050207    Free PMC article.
The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells.
Dominique N Lisiero, Horacio Soto, +2 authors, Robert M Prins.
J Immunother Cancer, 2014 Jul 24; 2. PMID: 25054063    Free PMC article.
Big bang theory of stem-like T cells confirmed.
Nicholas P Restifo.
Blood, 2014 Jul 26; 124(4). PMID: 25061170    Free PMC article.
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor.
James N Kochenderfer, Mark E Dudley, +23 authors, Steven A Rosenberg.
J Clin Oncol, 2014 Aug 27; 33(6). PMID: 25154820    Free PMC article.
Highly Cited.
T-cell immunotherapy: looking forward.
Jacqueline Corrigan-Curay, Hans-Peter Kiem, +23 authors, Donald B Kohn.
Mol Ther, 2014 Sep 05; 22(9). PMID: 25186558    Free PMC article.
IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.
Matthew C Walsh, Erika L Pearce, +3 authors, Yongwon Choi.
J Immunol, 2014 Sep 10; 193(8). PMID: 25200954    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy.
Mahesh Jonnalagadda, Armen Mardiros, +10 authors, Christine E Brown.
Mol Ther, 2014 Nov 05; 23(4). PMID: 25366031    Free PMC article.
Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors.
Eugene M Cozza, Timothy K Cooper, +2 authors, Todd D Schell.
Cancer Immunol Immunother, 2014 Nov 20; 64(3). PMID: 25408469    Free PMC article.
Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions.
Matthias Piesche, Vincent T Ho, +15 authors, Glenn Dranoff.
Clin Cancer Res, 2014 Dec 30; 21(5). PMID: 25538258    Free PMC article.
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.
Yun Ji, Claudia Wrzesinski, +14 authors, Luca Gattinoni.
Proc Natl Acad Sci U S A, 2014 Dec 31; 112(2). PMID: 25548153    Free PMC article.
The inducible costimulator augments Tc17 cell responses to self and tumor tissue.
Michelle H Nelson, Sreenath Kundimi, +9 authors, Chrystal M Paulos.
J Immunol, 2015 Jan 13; 194(4). PMID: 25576595    Free PMC article.
Mouse model for pre-clinical study of human cancer immunotherapy.
Zhiya Ya, Yared Hailemichael, Willem Overwijk, Nicholas P Restifo.
Curr Protoc Immunol, 2015 Feb 03; 108. PMID: 25640991    Free PMC article.
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement.
Corey Smith, Grethe Økern, +5 authors, Rajiv Khanna.
Clin Transl Immunology, 2015 Feb 12; 4(1). PMID: 25671129    Free PMC article.
Adoptive T cell immunotherapy for cancer.
Karlo Perica, Juan Carlos Varela, Mathias Oelke, Jonathan Schneck.
Rambam Maimonides Med J, 2015 Feb 27; 6(1). PMID: 25717386    Free PMC article.
Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care.
Katherine Riccione, Carter M Suryadevara, +3 authors, Luis Sanchez-Perez.
J Vis Exp, 2015 Mar 06; (96). PMID: 25741761    Free PMC article.
Beyond consolidation: auto-SCT and immunotherapy for plasma cell myeloma.
N Lendvai, A D Cohen, H J Cho.
Bone Marrow Transplant, 2015 Mar 10; 50(6). PMID: 25751647
Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways.
Scott M Anthony, Megan E Howard, +2 authors, Kimberly S Schluns.
PLoS One, 2015 Mar 11; 10(3). PMID: 25756182    Free PMC article.
Tumor infiltrating lymphocytes in ovarian cancer.
Phillip P Santoiemma, Daniel J Powell.
Cancer Biol Ther, 2015 Apr 22; 16(6). PMID: 25894333    Free PMC article.
Highly Cited. Review.
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.
Jacob S Bowers, Michelle H Nelson, +6 authors, Chrystal M Paulos.
Clin Cancer Res, 2015 Apr 24; 21(11). PMID: 25904754    Free PMC article.
Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas.
Catherine Flores, Christina Pham, +9 authors, Duane A Mitchell.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949916    Free PMC article.
4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling.
Ho S Oh, Beom K Choi, +6 authors, Byoung S Kwon.
PLoS One, 2015 May 12; 10(5). PMID: 25962156    Free PMC article.
Genetically modified T cells in cancer therapy: opportunities and challenges.
Michaela Sharpe, Natalie Mount.
Dis Model Mech, 2015 Jun 03; 8(4). PMID: 26035842    Free PMC article.
Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis.
Pali D Shah, Qiong Zhong, +2 authors, John F McDyer.
Viral Immunol, 2015 Jun 06; 28(5). PMID: 26046830    Free PMC article.
Adoptive T-cell therapy for Leukemia.
Haven R Garber, Asma Mirza, Elizabeth A Mittendorf, Gheath Alatrash.
Mol Cell Ther, 2014 Jan 01; 2. PMID: 26056592    Free PMC article.
A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy.
Julien Valton, Valérie Guyot, +5 authors, Laurent Poirot.
Mol Ther, 2015 Jun 11; 23(9). PMID: 26061646    Free PMC article.
Systemic LPS Translocation Activates Cross-Presenting Dendritic Cells but Is Dispensable for the Breakdown of CD8+ T Cell Peripheral Tolerance in Irradiated Mice.
Gabriel Espinosa-Carrasco, Marine Villard, +3 authors, Javier Hernandez.
PLoS One, 2015 Jun 16; 10(6). PMID: 26075613    Free PMC article.
Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study.
David J Klinke.
J Immunother Cancer, 2015 Jun 18; 3. PMID: 26082838    Free PMC article.
Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy.
Min Luo, Bin Shao, +7 authors, Yu-Quan Wei.
Sci Rep, 2015 Jun 23; 5. PMID: 26098663    Free PMC article.
Harnessing the Microbiome to Enhance Cancer Immunotherapy.
Michelle H Nelson, Marshall A Diven, Logan W Huff, Chrystal M Paulos.
J Immunol Res, 2015 Jun 24; 2015. PMID: 26101781    Free PMC article.
Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies-A review.
Sandeep Nayar, Prokar Dasgupta, Christine Galustian.
Oncoimmunology, 2015 Jul 15; 4(4). PMID: 26155387    Free PMC article.
Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy.
Karlo Perica, Joan Glick Bieler, +9 authors, Jonathan P Schneck.
ACS Nano, 2015 Jul 15; 9(7). PMID: 26171764    Free PMC article.
Immunotherapy of melanoma.
John B A G Haanen.
EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217118    Free PMC article.
Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Rα Dependent.
C Bryce Johnson, Brian P Riesenberg, +7 authors, Mark P Rubinstein.
Cancer Immunol Res, 2015 Aug 25; 3(12). PMID: 26297711    Free PMC article.
Immune Modulation in Hematologic Malignancies.
Madhav V Dhodapkar, Kavita M Dhodapkar.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320065    Free PMC article.
Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors.
Maël Heiblig, Mohamed Elhamri, Mauricette Michallet, Xavier Thomas.
World J Stem Cells, 2015 Sep 04; 7(7). PMID: 26328018    Free PMC article.
CAR-T Cell Therapy for Lymphoma.
Carlos A Ramos, Helen E Heslop, Malcolm K Brenner.
Annu Rev Med, 2015 Sep 04; 67. PMID: 26332003    Free PMC article.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Kyle A Wilson, Stephen R Goding, +2 authors, Paul Andrew Antony.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570    Free PMC article.
miR-155 releases the brakes on antitumor T cells.
Yun Ji, Luca Gattinoni.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405586    Free PMC article.
Idiotype-specific CD4(+) T cells eradicate disseminated myeloma.
O A Haabeth, A Tveita, +3 authors, B Bogen.
Leukemia, 2015 Oct 10; 30(5). PMID: 26449664
Trial Watch: Adoptive cell transfer for oncological indications.
Fernando Aranda, Aitziber Buqué, +11 authors, Lorenzo Galluzzi.
Oncoimmunology, 2015 Oct 10; 4(11). PMID: 26451319    Free PMC article.
T-cell Exhaustion in Multiple Myeloma Relapse after Autotransplant: Optimal Timing of Immunotherapy.
David J Chung, Katherine B Pronschinske, +7 authors, James W Young.
Cancer Immunol Res, 2015 Oct 16; 4(1). PMID: 26464015    Free PMC article.
T-cell receptor gene therapy--ready to go viral?
Terhi Karpanen, Johanna Olweus.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533    Free PMC article.
Tumor-infiltrating lymphocytes for the treatment of metastatic cancer.
M H Geukes Foppen, M Donia, I M Svane, J B A G Haanen.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578452    Free PMC article.
Chimeric Antigen Receptor T-Cells: New Approaches to Improve Their Efficacy and Reduce Toxicity.
Marcela V Maus, Daniel J Powell.
Cancer J, 2015 Nov 21; 21(6). PMID: 26588679    Free PMC article.
Common gamma chain cytokines in combinatorial immune strategies against cancer.
Stephanie R Pulliam, Roman V Uzhachenko, Samuel E Adunyah, Anil Shanker.
Immunol Lett, 2015 Nov 26; 169. PMID: 26597610    Free PMC article.
IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy.
Karolina Pilipow, Alessandra Roberto, +3 authors, Enrico Lugli.
Cancer Res, 2015 Dec 03; 75(24). PMID: 26627006    Free PMC article.
Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD.
Elad Jacoby, Yinmeng Yang, +3 authors, Terry J Fry.
Blood, 2015 Dec 15; 127(10). PMID: 26660684    Free PMC article.
Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.
Madhusudhanan Sukumar, Jie Liu, +22 authors, Nicholas P Restifo.
Cell Metab, 2015 Dec 18; 23(1). PMID: 26674251    Free PMC article.
Highly Cited.
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
Adriana M Mujal, Julia K Gilden, +2 authors, Matthew F Krummel.
Nat Immunol, 2015 Dec 23; 17(3). PMID: 26692174    Free PMC article.
Enhancing adoptive T cell immunotherapy with microRNA therapeutics.
Yun Ji, James D Hocker, Luca Gattinoni.
Semin Immunol, 2015 Dec 30; 28(1). PMID: 26710685    Free PMC article.
Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.
Jennifer N Brudno, Robert P T Somerville, +19 authors, James N Kochenderfer.
J Clin Oncol, 2016 Jan 27; 34(10). PMID: 26811520    Free PMC article.
Highly Cited.
Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy.
Hanren Dai, Yao Wang, Xuechun Lu, Weidong Han.
J Natl Cancer Inst, 2016 Jan 29; 108(7). PMID: 26819347    Free PMC article.
Highly Cited. Review.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen.
Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth.
Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
The Promise of Chimeric Antigen Receptor Engineered T Cells in the Treatment of Hematologic Malignancies.
Sarah J Nagle, Alfred L Garfall, Edward A Stadtmauer.
Cancer J, 2016 Feb 04; 22(1). PMID: 26841014    Free PMC article.
Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning.
Michelle H Nelson, Jacob S Bowers, +7 authors, Chrystal M Paulos.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885368    Free PMC article.
Role of memory T cell subsets for adoptive immunotherapy.
Dirk H Busch, Simon P Fräßle, +2 authors, Stanley R Riddell.
Semin Immunol, 2016 Mar 16; 28(1). PMID: 26976826    Free PMC article.
Highly Cited. Review.
A role for pre-mNK cells in tumor progression.
Carolyn Rosinsky, Paul Andrew Antony.
J Immunother Cancer, 2016 Mar 17; 4. PMID: 26981246    Free PMC article.
Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy.
Vita Golubovskaya, Lijun Wu.
Cancers (Basel), 2016 Mar 22; 8(3). PMID: 26999211    Free PMC article.
Highly Cited. Review.
Strategies to genetically engineer T cells for cancer immunotherapy.
Timothy T Spear, Kaoru Nagato, Michael I Nishimura.
Cancer Immunol Immunother, 2016 May 04; 65(6). PMID: 27138532    Free PMC article.
Opportunities in immunotherapy of ovarian cancer.
G Coukos, J Tanyi, L E Kandalaft.
Ann Oncol, 2016 May 04; 27 Suppl 1. PMID: 27141063    Free PMC article.
Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona, Eleftherios P Diamandis, Ivan M Blasutig.
BMC Med, 2016 May 07; 14. PMID: 27151159    Free PMC article.
Highly Cited. Review.
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia.
Aizhang Xu, Kalpana Kalyanasundaram Bhanumathy, +5 authors, Jim Xiang.
Cell Biosci, 2016 May 10; 6. PMID: 27158441    Free PMC article.
Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion.
Scott M Anthony, Sarai C Rivas, +3 authors, Kimberly S Schluns.
J Immunol, 2016 May 18; 196(11). PMID: 27183627    Free PMC article.
Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors.
Hiroki Torikai, Laurence Jn Cooper.
Mol Ther, 2016 May 21; 24(7). PMID: 27203439    Free PMC article.
CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date.
Jae H Park, Mark B Geyer, Renier J Brentjens.
Blood, 2016 May 22; 127(26). PMID: 27207800    Free PMC article.
Highly Cited. Review.
Immune Cells in Cancer Therapy and Drug Delivery.
Ceren Eyileten, Kinga Majchrzak, +8 authors, Tomasz P Rygiel.
Mediators Inflamm, 2016 May 24; 2016. PMID: 27212807    Free PMC article.
Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo.
Franziska Blaeschke, Uwe Thiel, +12 authors, Stefan Burdach.
Oncotarget, 2016 Jun 10; 7(28). PMID: 27281613    Free PMC article.
T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma.
Syed Abbas Ali, Victoria Shi, +11 authors, James N Kochenderfer.
Blood, 2016 Jul 15; 128(13). PMID: 27412889    Free PMC article.
Highly Cited.
Mechanisms of immune evasion and current status of checkpoint inhibitors in non-small cell lung cancer.
Angel Qin, David G Coffey, Edus H Warren, Nithya Ramnath.
Cancer Med, 2016 Jul 16; 5(9). PMID: 27416962    Free PMC article.
Effect of administration timing of postchemotherapy granulocyte colony-stimulating factor on host-immune cell recovery and CD8+ T-cell response.
Mohamed Labib Salem, Mohamed Nassef, +5 authors, David Cole.
J Immunotoxicol, 2016 Jul 16; 13(6). PMID: 27417188    Free PMC article.
Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells.
Katrin Deiser, Diana Stoycheva, +2 authors, Thomas Schüler.
PLoS One, 2016 Jul 23; 11(7). PMID: 27447484    Free PMC article.
Update on use of aldesleukin for treatment of high-risk metastatic melanoma.
Rodabe N Amaria, Alexandre Reuben, Zachary A Cooper, Jennifer A Wargo.
Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471714    Free PMC article.
A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma.
Todd Crocenzi, Benjamin Cottam, +12 authors, Marka R Crittenden.
J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532020    Free PMC article.
Harnessing the immune system to improve cancer therapy.
Nikos E Papaioannou, Ourania V Beniata, +2 authors, Pinelopi Samara.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563648    Free PMC article.
Highly Cited. Review.
Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.
Saad S Kenderian, David L Porter, Saar Gill.
Biol Blood Marrow Transplant, 2016 Sep 18; 23(2). PMID: 27638367    Free PMC article.
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination.
Anke Redeker, Ramon Arens.
Front Immunol, 2016 Sep 23; 7. PMID: 27656185    Free PMC article.
Generation of T cell effectors using tumor cell-loaded dendritic cells for adoptive T cell therapy.
Katerina Vavrova, Petra Vrabcova, +2 authors, Rudolf Horvath.
Med Oncol, 2016 Nov 05; 33(12). PMID: 27812850
Immune Regulation in Pregnancy: A Matter of Perspective?
Elizabeth A Bonney.
Obstet Gynecol Clin North Am, 2016 Nov 07; 43(4). PMID: 27816154    Free PMC article.
A subset of virus-specific CD161+ T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML.
Abdullah Alsuliman, Muharrem Muftuoglu, +17 authors, Katayoun Rezvani.
Blood, 2016 Nov 09; 129(6). PMID: 27821506    Free PMC article.
PD-1 inhibition and treatment of advanced melanoma-role of pembrolizumab.
Ali R Jazirehi, Alexandra Lim, Tam Dinh.
Am J Cancer Res, 2016 Nov 09; 6(10). PMID: 27822406    Free PMC article.
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity.
Michael S Magee, Crystal L Kraft, +5 authors, Adam E Snook.
Oncoimmunology, 2016 Nov 18; 5(10). PMID: 27853651    Free PMC article.
The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor Efficacy.
Jessica Ann Chacon, Keith Schutsky, Daniel J Powell.
Vaccines (Basel), 2016 Nov 18; 4(4). PMID: 27854240    Free PMC article.
Impact of Immune Deficiency on Remodeling of Maternal Resistance Vasculature 4 Weeks Postpartum in Mice.
Elizabeth A Bonney, Ann Howard, +3 authors, Natalia I Gokina.
Reprod Sci, 2016 Dec 03; 24(4). PMID: 27899739    Free PMC article.
Cellular and vaccine immunotherapy for multiple myeloma.
Alfred L Garfall, Edward A Stadtmauer.
Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913524    Free PMC article.
Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer.
Michel van Gelder, Ariane Vanclée, +3 authors, Gerard M Bos.
Breast Cancer Res Treat, 2016 Dec 05; 161(3). PMID: 27915436    Free PMC article.
Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion.
Sinnie Sin Man Ng, Bethany A Nagy, +6 authors, George N Pavlakis.
Clin Cancer Res, 2016 Dec 18; 23(11). PMID: 27986749    Free PMC article.
The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications.
Michael Spiotto, Yang-Xin Fu, Ralph R Weichselbaum.
Sci Immunol, 2016 Dec 27; 1(3). PMID: 28018989    Free PMC article.
Redirecting T cells to eradicate B-cell acute lymphoblastic leukemia: bispecific T-cell engagers and chimeric antigen receptors.
I Aldoss, R C Bargou, +3 authors, S J Forman.
Leukemia, 2016 Dec 29; 31(4). PMID: 28028314
Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies.
Baixin Ye, Creed M Stary, +5 authors, Xiaoxing Xiong.
J Immunol Res, 2017 Jan 25; 2017. PMID: 28116322    Free PMC article.
Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy.
Julien Fleurence, Sophie Fougeray, +5 authors, Stéphane Birklé.
J Immunol Res, 2017 Feb 06; 2017. PMID: 28154831    Free PMC article.
Manipulation of Innate and Adaptive Immunity through Cancer Vaccines.
Elias J Sayour, Duane A Mitchell.
J Immunol Res, 2017 Mar 08; 2017. PMID: 28265580    Free PMC article.
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.
Daniel J Neitzke, Jacob S Bowers, +7 authors, Mark P Rubinstein.
Cancer Immunol Immunother, 2017 Mar 11; 66(6). PMID: 28280853    Free PMC article.
Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.
Jacob S Bowers, Michelle H Nelson, +6 authors, Chrystal M Paulos.
JCI Insight, 2017 Mar 16; 2(5). PMID: 28289713    Free PMC article.
Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels.
James N Kochenderfer, Robert P T Somerville, +19 authors, Steven A Rosenberg.
J Clin Oncol, 2017 Mar 16; 35(16). PMID: 28291388    Free PMC article.
Highly Cited.
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers.
Chengcheng Zhang, Zhe Wang, +20 authors, Cheng Qian.
Mol Ther, 2017 Apr 04; 25(5). PMID: 28366766    Free PMC article.
Highly Cited.
CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond.
ZeNan L Chang, Yvonne Y Chen.
Trends Mol Med, 2017 Apr 19; 23(5). PMID: 28416139    Free PMC article.
β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity.
Kinga Majchrzak, Michelle H Nelson, +9 authors, Chrystal M Paulos.
JCI Insight, 2017 Apr 20; 2(8). PMID: 28422756    Free PMC article.
CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma.
Andras Heczey, Chrystal U Louis, +15 authors, Malcolm K Brenner.
Mol Ther, 2017 Jun 13; 25(9). PMID: 28602436    Free PMC article.
Highly Cited.
Cellular immunity augmentation in mainstream oncologic therapy.
Daohong Chen, Xiaoshi Zhang.
Cancer Biol Med, 2017 Jun 14; 14(2). PMID: 28607803    Free PMC article.
Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells.
Uwe Thiel, Sebastian J Schober, +16 authors, Stefan E G Burdach.
Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638739    Free PMC article.
Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40.
Aaron E Foster, Aruna Mahendravada, +15 authors, David M Spencer.
Mol Ther, 2017 Jul 13; 25(9). PMID: 28697888    Free PMC article.
Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy.
James N Kochenderfer, Robert P T Somerville, +8 authors, Steven A Rosenberg.
Mol Ther, 2017 Aug 15; 25(10). PMID: 28803861    Free PMC article.
Highly Cited.
The Basics of Artificial Antigen Presenting Cells in T Cell-Based Cancer Immunotherapies.
Lillian R Neal, Stefanie R Bailey, +6 authors, Juan C Varela.
J Immunol Res Ther, 2017 Aug 22; 2(1). PMID: 28825053    Free PMC article.
Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells.
Tomohiro Tanaka, Satoshi Watanabe, +20 authors, Toshiaki Kikuchi.
PLoS One, 2017 Aug 31; 12(8). PMID: 28854279    Free PMC article.
Chimeric antigen receptor T-cell therapies for lymphoma.
Jennifer N Brudno, James N Kochenderfer.
Nat Rev Clin Oncol, 2017 Sep 01; 15(1). PMID: 28857075
Highly Cited. Review.
Improvement in diagnostic and therapeutic arthrocentesis via constant compression.
Tej B Bhavsar, Wilmer L Sibbitt, +9 authors, Arthur D Bankhurst.
Clin Rheumatol, 2017 Sep 16; 37(8). PMID: 28913649
Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells.
Aurélie Hanoteau, Coralie Henin, +7 authors, Muriel Moser.
Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28919989    Free PMC article.
Chimeric antigen receptor T-cell therapies for multiple myeloma.
Lekha Mikkilineni, James N Kochenderfer.
Blood, 2017 Sep 21; 130(24). PMID: 28928126    Free PMC article.
Highly Cited. Review.
Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells.
Zhi-Chun Ding, Tsadik Habtetsion, +8 authors, Gang Zhou.
Sci Rep, 2017 Sep 25; 7(1). PMID: 28939858    Free PMC article.
Immunotherapy for Pediatric Brain Tumors.
Elias J Sayour, Duane A Mitchell.
Brain Sci, 2017 Oct 27; 7(10). PMID: 29065490    Free PMC article.
Chimeric Antigen Receptor (CAR) T-Cell Therapy for Thoracic Malignancies.
Stefan Kiesgen, Leonardo Chicaybam, Navin K Chintala, Prasad S Adusumilli.
J Thorac Oncol, 2017 Nov 07; 13(1). PMID: 29107016    Free PMC article.
Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes.
Kunyu Li, Braeden Donaldson, +4 authors, Sarah Young.
Clin Transl Immunology, 2017 Nov 09; 6(10). PMID: 29114389    Free PMC article.
Trial Watch: Adoptively transferred cells for anticancer immunotherapy.
Carole Fournier, François Martin, +3 authors, Lionel Apetoh.
Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147628    Free PMC article.
Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology.
Joseph G Crompton, Nicholas Klemen, Udai S Kammula.
Ann Surg Oncol, 2017 Dec 01; 25(2). PMID: 29188500    Free PMC article.
Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors.
Lindsay K Ward-Kavanagh, Kathleen M Kokolus, +2 authors, Todd D Schell.
Cancer Immunol Immunother, 2018 Jan 15; 67(4). PMID: 29332158    Free PMC article.
Immunotherapy of cancer: targeting cancer during active disease or during dormancy?
Syed Ammer Shah, Melika Zarei, +3 authors, Masoud H Manjili.
Immunotherapy, 2018 Jan 18; 9(11). PMID: 29338608    Free PMC article.
CD19 CAR T Cells Expressing IL-12 Eradicate Lymphoma in Fully Lymphoreplete Mice through Induction of Host Immunity.
Gray Kueberuwa, Milena Kalaitsidou, +2 authors, David Edward Gilham.
Mol Ther Oncolytics, 2018 Jan 26; 8. PMID: 29367945    Free PMC article.
Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients.
Jean-Marc Hoffmann, Maria-Luisa Schubert, +13 authors, Michael Schmitt.
Front Immunol, 2018 Jan 30; 8. PMID: 29375575    Free PMC article.
Radiation effects on antitumor immune responses: current perspectives and challenges.
Thomas Walle, Rafael Martinez Monge, +3 authors, Fernando Lecanda.
Ther Adv Med Oncol, 2018 Feb 01; 10. PMID: 29383033    Free PMC article.
Highly Cited. Review.
IL-2 and Beyond in Cancer Immunotherapy.
John M Wrangle, Alicia Patterson, +7 authors, Mark P Rubinstein.
J Interferon Cytokine Res, 2018 Feb 15; 38(2). PMID: 29443657    Free PMC article.
T-cell Immunotherapies and the Role of Nonclinical Assessment: The Balance between Efficacy and Pathology.
Michaela E Sharpe.
Toxicol Pathol, 2018 Feb 24; 46(2). PMID: 29471776    Free PMC article.
Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.
Dionysios C Watson, Eirini Moysi, +14 authors, George N Pavlakis.
PLoS Pathog, 2018 Feb 24; 14(2). PMID: 29474450    Free PMC article.
Highly Cited.
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
Jonathan T Sockolosky, Eleonora Trotta, +15 authors, K Christopher Garcia.
Science, 2018 Mar 03; 359(6379). PMID: 29496879    Free PMC article.
Highly Cited.
Chimeric Antigen Receptor T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia.
Ciprian Tomuleasa, Shigeo Fuji, +13 authors, Shigehisa Kitano.
Front Immunol, 2018 Mar 09; 9. PMID: 29515572    Free PMC article.
The Pharmacology of T Cell Therapies.
Michael C Milone, Vijay G Bhoj.
Mol Ther Methods Clin Dev, 2018 Mar 20; 8. PMID: 29552577    Free PMC article.
Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases.
Michael S Magee, Tara S Abraham, +7 authors, Adam E Snook.
Cancer Immunol Res, 2018 Apr 05; 6(5). PMID: 29615399    Free PMC article.
Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8+ T Cells.
C Bryce Johnson, Bennett R May, +10 authors, Mark P Rubinstein.
Cancer Res, 2018 Apr 11; 78(11). PMID: 29636345    Free PMC article.
Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma.
Tyler J Wildes, Adam Grippin, +5 authors, Duane A Mitchell.
Clin Cancer Res, 2018 May 02; 24(16). PMID: 29712687    Free PMC article.
Chimeric antigen receptor-modified T cells: CD19 and the road beyond.
Alexander I Salter, Margot J Pont, Stanley R Riddell.
Blood, 2018 May 08; 131(24). PMID: 29728402    Free PMC article.
Highly Cited. Review.
Temozolomide for immunomodulation in the treatment of glioblastoma.
Aida Karachi, Farhad Dastmalchi, Duane A Mitchell, Maryam Rahman.
Neuro Oncol, 2018 May 08; 20(12). PMID: 29733389    Free PMC article.
T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma.
Jennifer N Brudno, Irina Maric, +18 authors, James N Kochenderfer.
J Clin Oncol, 2018 May 31; 36(22). PMID: 29812997    Free PMC article.
Highly Cited.
Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma.
Carter M Suryadevara, Rupen Desai, +14 authors, Luis Sanchez-Perez.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872570    Free PMC article.
Chimeric antigen receptor T‑cell therapy-a hematological success story.
Philipp Wohlfarth, Nina Worel, Georg Hopfinger.
Memo, 2018 Jul 10; 11(2). PMID: 29983827    Free PMC article.
Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy.
João Manuel Santos, Víctor Cervera-Carrascon, +6 authors, Akseli Hemminki.
Mol Ther, 2018 Jul 19; 26(9). PMID: 30017877    Free PMC article.
Adoptive Cell Therapy in Treating Pediatric Solid Tumors.
Mekdem Tesfaye, Barbara Savoldo.
Curr Oncol Rep, 2018 Aug 03; 20(9). PMID: 30069644    Free PMC article.
Novel Therapies in Acute Lymphoblastic Leukemia.
Kathleen W Phelan, Anjali S Advani.
Curr Hematol Malig Rep, 2018 Aug 06; 13(4). PMID: 30078158
The application of CAR-T cell therapy in hematological malignancies: advantages and challenges.
Zijun Zhao, Yu Chen, +2 authors, Minhao Wu.
Acta Pharm Sin B, 2018 Aug 16; 8(4). PMID: 30109179    Free PMC article.
Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells.
Juhee Kim, Jun Young Lee, +6 authors, Jae-Ho Cho.
Front Immunol, 2018 Sep 08; 9. PMID: 30190718    Free PMC article.
The efficacy and safety of anti-CD19/CD20 chimeric antigen receptor- T cells immunotherapy in relapsed or refractory B-cell malignancies:a meta-analysis.
Hui Zhou, Yuling Luo, +5 authors, Xuelei Ma.
BMC Cancer, 2018 Sep 28; 18(1). PMID: 30257649    Free PMC article.
Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option.
Maartje W Rohaan, Joost H van den Berg, Pia Kvistborg, John B A G Haanen.
J Immunother Cancer, 2018 Oct 05; 6(1). PMID: 30285902    Free PMC article.
Adoptive cell transfer: new perspective treatment in veterinary oncology.
Joanna Katarzyna Bujak, Rafał Pingwara, Michelle Hase Nelson, Kinga Majchrzak.
Acta Vet Scand, 2018 Oct 12; 60(1). PMID: 30305130    Free PMC article.
CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge.
Sonia Guedan, Ramon Alemany.
Front Immunol, 2018 Nov 09; 9. PMID: 30405639    Free PMC article.
CAR T Cell Therapy for Neuroblastoma.
Rebecca M Richards, Elena Sotillo, Robbie G Majzner.
Front Immunol, 2018 Nov 22; 9. PMID: 30459759    Free PMC article.
Oncolytic Viruses: Priming Time for Cancer Immunotherapy.
Luke Russell, Kah Whye Peng, Stephen J Russell, Rosa Maria Diaz.
BioDrugs, 2019 Jul 20; 33(5). PMID: 31321623    Free PMC article.
Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors.
Rebecca J Brownlie, David Wright, Rose Zamoyska, Robert J Salmond.
JCI Insight, 2019 Jul 25; 5. PMID: 31335326    Free PMC article.
CAR T cells for brain tumors: Lessons learned and road ahead.
David Akhavan, Darya Alizadeh, +3 authors, Christine E Brown.
Immunol Rev, 2019 Jul 30; 290(1). PMID: 31355493    Free PMC article.
Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade.
Netonia Marshall, Keino Hutchinson, +7 authors, Joshua D Brody.
Cancer Discov, 2019 Aug 04; 9(11). PMID: 31375522    Free PMC article.
The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right.
Derek S Park, Mark Robertson-Tessi, +4 authors, Alexander R A Anderson.
Cancer Res, 2019 Aug 08; 79(20). PMID: 31387920    Free PMC article.
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.
Ping-Hsien Lee, Tori N Yamamoto, +11 authors, Nicholas P Restifo.
J Exp Med, 2019 Aug 14; 216(11). PMID: 31405895    Free PMC article.
Application Of Adoptive Immunotherapy In Ovarian Cancer.
Siyu Yang, Xiaojiao Yin, Ying Yue, Siqing Wang.
Onco Targets Ther, 2019 Oct 22; 12. PMID: 31632055    Free PMC article.
Resistance Mechanisms to CAR T-Cell Therapy and Overcoming Strategy in B-Cell Hematologic Malignancies.
Moo-Kon Song, Byeong-Bae Park, Ji-Eun Uhm.
Int J Mol Sci, 2019 Oct 30; 20(20). PMID: 31658644    Free PMC article.
Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice.
Matthias Mulazzani, Simon P Fräßle, +14 authors, Louisa von Baumgarten.
Proc Natl Acad Sci U S A, 2019 Nov 13; 116(48). PMID: 31712432    Free PMC article.
Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies.
Xinjie Xu, Qihang Sun, +8 authors, Yuhua Li.
Front Immunol, 2019 Dec 05; 10. PMID: 31798590    Free PMC article.
CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer.
Ryan Zander, David Schauder, +4 authors, Weiguo Cui.
Immunity, 2019 Dec 08; 51(6). PMID: 31810883    Free PMC article.
Highly Cited.
Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy.
Sophia Stock, Michael Schmitt, Leopold Sellner.
Int J Mol Sci, 2019 Dec 15; 20(24). PMID: 31835562    Free PMC article.
Immunotherapy for advanced melanoma.
Lei Fang, Anke S Lonsdorf, Sam T Hwang.
J Invest Dermatol, 2008 Oct 18; 128(11). PMID: 18927541    Free PMC article.
The influence of the commensal microbiota on distal tumor-promoting inflammation.
Claire M Buchta Rosean, Melanie R Rutkowski.
Semin Immunol, 2017 Jul 09; 32. PMID: 28687194    Free PMC article.
Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.
Talha Badar, Nirav N Shah.
Curr Treat Options Oncol, 2020 Feb 07; 21(2). PMID: 32025828
Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE).
Ibrahim Yakoub-Agha, Christian Chabannon, +23 authors, Nicolaus Kröger.
Haematologica, 2019 Nov 23; 105(2). PMID: 31753925    Free PMC article.
NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.
Rebecca B Delconte, Geoffrey Guittard, +7 authors, Nicholas D Huntington.
Front Immunol, 2020 Feb 23; 11. PMID: 32082327    Free PMC article.
Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management.
Jennifer N Brudno, James N Kochenderfer.
Blood Rev, 2018 Dec 12; 34. PMID: 30528964    Free PMC article.
Highly Cited. Review.
Engineering for Success: Approaches to Improve Chimeric Antigen Receptor T Cell Therapy for Solid Tumors.
Melinda Mata, Stephen Gottschalk.
Drugs, 2019 Feb 24; 79(4). PMID: 30796733    Free PMC article.
Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
Carter M Suryadevara, Rupen Desai, +12 authors, Luis Sanchez-Perez.
Clin Cancer Res, 2018 Nov 15; 25(1). PMID: 30425092    Free PMC article.
Cell-based immunotherapy approaches for multiple myeloma.
Katharina Kriegsmann, Mark Kriegsmann, +5 authors, Michael Hundemer.
Br J Cancer, 2018 Dec 07; 120(1). PMID: 30518815    Free PMC article.
Lymphopenia in Cancer Patients and its Effects on Response to Immunotherapy: an opportunity for combination with Cytokines?
Christine Ménétrier-Caux, Isabelle Ray-Coquard, Jean-Yves Blay, Christophe Caux.
J Immunother Cancer, 2019 Mar 30; 7(1). PMID: 30922400    Free PMC article.
Highly Cited. Review.
Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma.
Cesar Sommer, Bijan Boldajipour, +21 authors, Barbra J Sasu.
Mol Ther, 2019 Apr 22; 27(6). PMID: 31005597    Free PMC article.
Highly Cited.
First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia.
Sarah Cooley, Fiona He, +11 authors, Jeffrey S Miller.
Blood Adv, 2019 Jul 04; 3(13). PMID: 31266741    Free PMC article.
Highly Cited.
Current Status and Future Directions of Immunotherapy in Renal Cell Carcinoma.
Bryden Considine, Michael E Hurwitz.
Curr Oncol Rep, 2019 Mar 09; 21(4). PMID: 30848378
State of the art in CAR T cell therapy for CD19+ B cell malignancies.
Matthew J Frigault, Marcela V Maus.
J Clin Invest, 2020 Apr 03; 130(4). PMID: 32235098    Free PMC article.
Bispecific CAR-T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia.
Hanren Dai, Zhiqiang Wu, +12 authors, Weidong Han.
J Hematol Oncol, 2020 Apr 05; 13(1). PMID: 32245502    Free PMC article.
Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors.
Christopher DeRenzo, Stephen Gottschalk.
Front Immunol, 2019 Mar 05; 10. PMID: 30828333    Free PMC article.
Highly Cited. Review.
Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward.
Leila Jafarzadeh, Elham Masoumi, +2 authors, Jamshid Hadjati.
Front Immunol, 2020 May 12; 11. PMID: 32391013    Free PMC article.
Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells.
Rowa Y Alhabbab.
Front Genet, 2020 May 12; 11. PMID: 32391048    Free PMC article.
Engineering bionic T cells: signal 1, signal 2, signal 3, reprogramming and the removal of inhibitory mechanisms.
Iñaki Etxeberria, Irene Olivera, +4 authors, Ignacio Melero.
Cell Mol Immunol, 2020 May 21; 17(6). PMID: 32433539    Free PMC article.
Novel agents for B-cell non-Hodgkin lymphoma: science and the promise.
Kevin Tay, Kieron Dunleavy, Wyndham H Wilson.
Blood Rev, 2010 Feb 16; 24(2). PMID: 20153097    Free PMC article.
Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium.
Nisha Kannan, Markus Haug, Magnus Steigedal, Trude Helen Flo.
Front Immunol, 2020 Jun 26; 11. PMID: 32582196    Free PMC article.
[Anti-CD19 chimeric antigen receptor T cells (CART-19) for hemotological malignancies therapy].
Hejin Jia, Weidong Han.
Zhonghua Xue Ye Xue Za Zhi, 2016 Mar 26; 37(2). PMID: 27014991    Free PMC article.
Emerging Cellular Therapies for Cancer.
Sonia Guedan, Marco Ruella, Carl H June.
Annu Rev Immunol, 2018 Dec 12; 37. PMID: 30526160    Free PMC article.
Highly Cited. Review.
CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells.
Marion Alcantara, Melania Tesio, Carl H June, Roch Houot.
Leukemia, 2018 Oct 14; 32(11). PMID: 30315238    Free PMC article.
CAR-T Cell Therapy for Lymphoma: How Does Radiation Therapy Fit In?
Alexandra D Dreyfuss, Michael Lariviere, Leslie K Ballas, John P Plastaras.
Pract Radiat Oncol, 2019 Oct 02; 10(3). PMID: 31574320    Free PMC article.
CAR T-Cells in Multiple Myeloma: State of the Art and Future Directions.
Luis Gerardo Rodríguez-Lobato, Maya Ganzetti, +3 authors, Sophia Danhof.
Front Oncol, 2020 Aug 28; 10. PMID: 32850376    Free PMC article.
Chimeric antigen receptor T-cell therapies: Optimising the dose.
Nathaniel Dasyam, Philip George, Robert Weinkove.
Br J Clin Pharmacol, 2020 Mar 17; 86(9). PMID: 32175617    Free PMC article.
B-Cell Maturation Antigen (BCMA) as a Target for New Drug Development in Relapsed and/or Refractory Multiple Myeloma.
Hanley N Abramson.
Int J Mol Sci, 2020 Jul 28; 21(15). PMID: 32707894    Free PMC article.
Host lymphocyte depletion as a strategy to facilitate early full donor chimerism after reduced-intensity allogeneic stem cell transplantation.
Rachel B Salit, Daniel H Fowler, +7 authors, Michael R Bishop.
Biol Blood Marrow Transplant, 2013 Aug 21; 19(10). PMID: 23948062    Free PMC article.
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells.
Takaaki Oba, Toshifumi Hoki, +4 authors, Fumito Ito.
J Immunol, 2020 Aug 28; 205(7). PMID: 32848036    Free PMC article.
To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors.
Anna Mondino, Teresa Manzo.
Front Immunol, 2020 Sep 26; 11. PMID: 32973794    Free PMC article.
Antigenic Targets for the Immunotherapy of Acute Myeloid Leukaemia.
Ghazala Naz Khan, Kim Orchard, Barbara-Ann Guinn.
J Clin Med, 2019 Jan 27; 8(2). PMID: 30678059    Free PMC article.
Dawn of Chimeric Antigen Receptor T Cell Therapy in Non-Hodgkin Lymphoma.
Karlo Perica, Lia Palomba, Renier J Brentjens.
Adv Cell Gene Ther, 2018 Nov 01; 1(3). PMID: 33043278    Free PMC article.
Reactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell Therapy.
Patrick Innamarato, Krithika Kodumudi, +9 authors, Shari Pilon-Thomas.
Mol Ther, 2020 Jul 03; 28(10). PMID: 32615068    Free PMC article.
Hematopoietic stem cell transplantation and chimeric antigen receptor T cell for relapsed or refractory diffuse large B-cell lymphoma.
Tao Wang, Lei Gao, +11 authors, Jianmin Yang.
Immunotherapy, 2020 Aug 06; 12(13). PMID: 32752910    Free PMC article.
Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy.
Wojciech Dawicki, Kevin J H Allen, +4 authors, Ekaterina Dadachova.
Oncotarget, 2020 Oct 17; 11(39). PMID: 33062193    Free PMC article.
Proton Therapy as a Bridging Treatment in CAR T-Cell Therapy for Relapsed and Refractory Large B-Cell Lymphoma: Is There a Role?
Omran Saifi, Mohamed A Kharfan-Dabaja, +4 authors, Bradford S Hoppe.
Int J Part Ther, 2020 Oct 24; 7(1). PMID: 33094131    Free PMC article.
The Landscape of CAR-T Cell Clinical Trials against Solid Tumors-A Comprehensive Overview.
Niels Schaft.
Cancers (Basel), 2020 Sep 13; 12(9). PMID: 32916883    Free PMC article.
Leveraging Endogenous Dendritic Cells to Enhance the Therapeutic Efficacy of Adoptive T-Cell Therapy and Checkpoint Blockade.
Mie Linder Hübbe, Ditte Elisabeth Jæhger, Thomas Lars Andresen, Mads Hald Andersen.
Front Immunol, 2020 Oct 27; 11. PMID: 33101304    Free PMC article.
Interleukin-15 and cancer: some solved and many unsolved questions.
Piera Filomena Fiore, Sabina Di Matteo, +8 authors, Bruno Azzarone.
J Immunother Cancer, 2020 Nov 19; 8(2). PMID: 33203664    Free PMC article.
Perspective on potential clinical applications of recombinant human interleukin-7.
Claude Sportès, Ronald E Gress, Crystal L Mackall.
Ann N Y Acad Sci, 2010 Jan 16; 1182. PMID: 20074272    Free PMC article.
Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice.
Dhanalakshmi Chinnasamy, Zhiya Yu, +4 authors, Steven A Rosenberg.
Clin Cancer Res, 2012 Feb 01; 18(6). PMID: 22291136    Free PMC article.
Highly Cited.
Cellular constituents of immune escape within the tumor microenvironment.
Sid P Kerkar, Nicholas P Restifo.
Cancer Res, 2012 Jun 23; 72(13). PMID: 22721837    Free PMC article.
Highly Cited. Review.
Adoptive cell transfer for patients with metastatic melanoma: the potential and promise of cancer immunotherapy.
Giao Q Phan, Steven A Rosenberg.
Cancer Control, 2013 Oct 01; 20(4). PMID: 24077405    Free PMC article.
Adoptive cell transfer as personalized immunotherapy for human cancer.
Steven A Rosenberg, Nicholas P Restifo.
Science, 2015 Apr 04; 348(6230). PMID: 25838374    Free PMC article.
Highly Cited. Review.
Adoptive Cell Therapy--Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors.
Steven A Feldman, Yasmine Assadipour, +2 authors, Steven A Rosenberg.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320066    Free PMC article.
Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques.
Cristina Bergamaschi, Dionysios C Watson, +5 authors, George N Pavlakis.
Cytokine, 2018 Feb 07; 108. PMID: 29402721    Free PMC article.
The use of chimeric antigen receptor T cells in patients with non-Hodgkin lymphoma.
Premal D Lulla, LaQuisa C Hill, Carlos A Ramos, Helen E Heslop.
Clin Adv Hematol Oncol, 2018 Jun 01; 16(5). PMID: 29851933    Free PMC article.
The promise of CAR T-cell therapy in aggressive B-cell lymphoma.
Ranjit Nair, Sattva S Neelapu.
Best Pract Res Clin Haematol, 2018 Sep 15; 31(3). PMID: 30213399    Free PMC article.
The expression of MHC class II molecules on murine breast tumors delays T-cell exhaustion, expands the T-cell repertoire, and slows tumor growth.
Tyler R McCaw, Mei Li, +7 authors, Troy D Randall.
Cancer Immunol Immunother, 2018 Oct 20; 68(2). PMID: 30334128    Free PMC article.
Adoptive cellular therapies: the current landscape.
Maartje W Rohaan, Sofie Wilgenhof, John B A G Haanen.
Virchows Arch, 2018 Nov 25; 474(4). PMID: 30470934    Free PMC article.
Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy.
Zhao Zhang, Jun Jiang, +7 authors, Zhinan Chen.
Front Med, 2019 Feb 06; 13(1). PMID: 30721445
Lymphopenia predicts response to stereotactic radiosurgery in lung cancer patients with brain metastases.
Yuping D Li, Jason B Lamano, +5 authors, Orin Bloch.
J Neurooncol, 2019 Apr 15; 143(2). PMID: 30982197
Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma.
Jennifer N Brudno, Norris Lam, +17 authors, James N Kochenderfer.
Nat Med, 2020 Jan 22; 26(2). PMID: 31959992    Free PMC article.
CART Cell Toxicities: New Insight into Mechanisms and Management.
Anas Zahid, Elizabeth L Siegler, Saad S Kenderian.
Clin Hematol Int, 2021 Jan 08; 2(4). PMID: 33409484    Free PMC article.
CD4+ T cell exhaustion leads to adoptive transfer therapy failure which can be prevented by immune checkpoint blockade.
Jinfei Fu, Anze Yu, +4 authors, Bin He.
Am J Cancer Res, 2021 Jan 09; 10(12). PMID: 33414997    Free PMC article.
Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.
Xiang Zhou, Leo Rasche, +3 authors, Hermann Einsele.
Front Immunol, 2021 Jan 12; 11. PMID: 33424871    Free PMC article.
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma.
Giulia Agliardi, Anna Rita Liuzzi, +17 authors, Burkhard Becher.
Nat Commun, 2021 Jan 21; 12(1). PMID: 33469002    Free PMC article.
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes.
Emiliano Roselli, Rawan Faramand, Marco L Davila.
J Clin Invest, 2021 Jan 20; 131(2). PMID: 33463538    Free PMC article.
CAR T cell therapies for patients with multiple myeloma.
Lekha Mikkilineni, James N Kochenderfer.
Nat Rev Clin Oncol, 2020 Sep 27; 18(2). PMID: 32978608
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.
Alba Rodriguez-Garcia, Rachel C Lynn, +8 authors, Daniel J Powell.
Nat Commun, 2021 Feb 11; 12(1). PMID: 33563975    Free PMC article.
Translatable gene therapy for lung cancer using Crispr CAS9-an exploratory review.
Jishnu Nair, Abhishek Nair, Soundaram Veerappan, Dwaipayan Sen.
Cancer Gene Ther, 2019 Jun 22; 27(3-4). PMID: 31222183
Reactive myelopoiesis and the onset of myeloid-mediated immune suppression: Implications for adoptive cell therapy.
Patrick Innamarato, Shari Pilon-Thomas.
Cell Immunol, 2021 Jan 22; 361. PMID: 33476931    Free PMC article.
Chimeric antigen receptor T cell therapy for pediatric and young adult B cell acute lymphoblastic leukemia.
Regina M Myers, Joseph Dolan, David T Teachey.
Expert Rev Clin Immunol, 2020 Sep 26; 16(10). PMID: 32975147    Free PMC article.
Lymphopenia-induced lymphoproliferation drives activation of naive T cells and expansion of regulatory populations.
Eldershaw S, Verma K, +8 authors, Moss P.
iScience, 2021 Mar 06; 24(3). PMID: 33665580    Free PMC article.
Adoptive immunotherapies in neuro-oncology: classification, recent advances, and translational challenges.
Sabino Luzzi, Alice Giotta Lucifero, +4 authors, Thomas Foiadelli.
Acta Biomed, 2020 Jul 02; 91(7-S). PMID: 32608373    Free PMC article.
Autologous Stem Cell Transplantation for Myeloma: Cytoreduction or an Immunotherapy?
Simone A Minnie, Geoffrey R Hill.
Front Immunol, 2021 Mar 30; 12. PMID: 33777050    Free PMC article.
Tumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokine.
Seung E Cha, Maciej Kujawski, +2 authors, John E Shively.
Oncoimmunology, 2021 Apr 03; 10(1). PMID: 33796409    Free PMC article.
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines.
Coral García-Fernández, Anna Saz, Cristina Fornaguera, Salvador Borrós.
Cancer Gene Ther, 2021 Apr 11; 28(9). PMID: 33837365
Adoptive T Cell Therapy for Solid Tumors: Pathway to Personalized Standard of Care.
Shuyang S Qin, Alexa D Melucci, Alexander C Chacon, Peter A Prieto.
Cells, 2021 May 01; 10(4). PMID: 33916369    Free PMC article.
Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment.
Jennifer Frosch, Ilia Leontari, John Anderson.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33917501    Free PMC article.
Are chimeric antigen receptor T cells (CAR-T cells) the future in immunotherapy for autoimmune diseases?
Yeison Santamaria-Alza, Gloria Vasquez.
Inflamm Res, 2021 May 22; 70(6). PMID: 34018005
Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy.
Abraham Nissani, Shaked Lev-Ari, +8 authors, Michal J Besser.
J Immunother Cancer, 2021 May 16; 9(5). PMID: 33990415    Free PMC article.
The role of small molecules in cell and gene therapy.
Lewis L Brayshaw, Carlos Martinez-Fleites, +3 authors, Christopher Herring.
RSC Med Chem, 2021 May 29; 12(3). PMID: 34046619    Free PMC article.
Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer.
Amrendra Kumar, Reese Watkins, Anna E Vilgelm.
Front Immunol, 2021 Jun 19; 12. PMID: 34140957    Free PMC article.
Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy.
Ramazan Rezaei, Hadi Esmaeili Gouvarchin Ghaleh, +5 authors, Akbar Ghorbani Alvanegh.
Cancer Gene Ther, 2021 Jun 24;. PMID: 34158626
Endometrial Carcinoma: Immune Microenvironment and Emerging Treatments in Immuno-Oncology.
Sandrine Rousset-Rouviere, Philippe Rochigneux, +6 authors, Renaud Sabatier.
Biomedicines, 2021 Jul 03; 9(6). PMID: 34199461    Free PMC article.
The "Magic Bullet" Is Here? Cell-Based Immunotherapies for Hematological Malignancies in the Twilight of the Chemotherapy Era.
Nina Miazek-Zapala, Aleksander Slusarczyk, +4 authors, Malgorzata Bobrowicz.
Cells, 2021 Jul 03; 10(6). PMID: 34203935    Free PMC article.
The potential of CAR T cell therapy for prostate cancer.
Philipp Wolf, Jamal Alzubi, Christian Gratzke, Toni Cathomen.
Nat Rev Urol, 2021 Jul 10; 18(9). PMID: 34239139
Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity.
John P Murad, Dileshni Tilakawardane, +15 authors, Saul J Priceman.
Mol Ther, 2021 Mar 02; 29(7). PMID: 33647456    Free PMC article.
Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead.
Kedar Kirtane, Hany Elmariah, Christine H Chung, Daniel Abate-Daga.
J Immunother Cancer, 2021 Jul 25; 9(7). PMID: 34301811    Free PMC article.
IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model.
Eun M Yu, Eunjung Cho, +7 authors, Beom K Choi.
Cells, 2021 Aug 28; 10(8). PMID: 34440787    Free PMC article.
Engineering enhanced CAR T-cells for improved cancer therapy.
Michael C Milone, Jie Xu, +4 authors, J Joseph Melenhorst.
Nat Cancer, 2021 Sep 07; 2(8). PMID: 34485921    Free PMC article.
Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells.
Seon-Hee Kim, Eunjung Cho, +3 authors, Byoung S Kwon.
Nat Commun, 2021 Sep 09; 12(1). PMID: 34493727    Free PMC article.
The emerging roles of the gut microbiome in allogeneic hematopoietic stem cell transplantation.
Lam T Khuat, Maneesh Dave, William J Murphy.
Gut Microbes, 2021 Aug 31; 13(1). PMID: 34455917    Free PMC article.
Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and -γ.
Sanjay Chandrasekaran, Christopher Ronald Funk, +3 authors, Edmund K Waller.
Front Immunol, 2021 Sep 14; 12. PMID: 34512641    Free PMC article.
Immunotherapy of Multiple Myeloma: Promise and Challenges.
Hanley N Abramson.
Immunotargets Ther, 2021 Sep 17; 10. PMID: 34527606    Free PMC article.
State of the CAR-T: Risk of Infections with Chimeric Antigen Receptor T-Cell Therapy and Determinants of SARS-CoV-2 Vaccine Responses.
Juliet Meir, Muhammad Abbas Abid, Muhammad Bilal Abid.
Transplant Cell Ther, 2021 Sep 30; 27(12). PMID: 34587552    Free PMC article.
Improving CAR T-Cell Persistence.
Violena Pietrobon, Lauren Anne Todd, +3 authors, Francesco Marincola.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639168    Free PMC article.
PD-1 blockade therapy augments the antitumor effects of lymphodepletion and adoptive T cell transfer.
Miho Takahashi, Satoshi Watanabe, +18 authors, Toshiaki Kikuchi.
Cancer Immunol Immunother, 2021 Oct 18;. PMID: 34657194
Optimizing the Clinical Impact of CAR-T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia: Looking Back While Moving Forward.
Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, Fatemeh Rahbarizadeh.
Front Immunol, 2021 Nov 16; 12. PMID: 34777381    Free PMC article.
Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia.
Adriana Seber, Claudio Galvão de CastroJunior, +12 authors, Henrique Bittencourt.
Hematol Transfus Cell Ther, 2021 Nov 20; 43 Suppl 2. PMID: 34794791    Free PMC article.
Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors.
Kevin Conlon, Dionysios C Watson, +19 authors, George N Pavlakis.
J Immunother Cancer, 2021 Nov 21; 9(11). PMID: 34799399    Free PMC article.
T Cell Engaging Immunotherapies, Highlighting Chimeric Antigen Receptor (CAR) T Cell Therapy.
Elien De Bousser, Nico Callewaert, Nele Festjens.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885176    Free PMC article.
T Cell Fitness and Autologous CAR T Cell Therapy in Haematologic Malignancy.
Palak H Mehta, Salvatore Fiorenza, +3 authors, Kylie M Quinn.
Front Immunol, 2021 Dec 14; 12. PMID: 34899742    Free PMC article.
Genetically engineered CAR T-immune cells for cancer therapy: recent clinical developments, challenges, and future directions.
Sherien M El-Daly, Jihan Hussein.
J Appl Biomed, 2019 Mar 01; 17(1). PMID: 34907752
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies.
Jian-Qing Mi, Jie Xu, +4 authors, Saijuan Chen.
Front Med, 2021 Dec 19; 15(6). PMID: 34921673
Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer.
Evgenii Skurikhin, Olga Pershina, +7 authors, Alexander Dygai.
Front Cell Dev Biol, 2021 Dec 21; 9. PMID: 34926461    Free PMC article.
Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors.
Yasushi Kimura, Mario Ghosn, +3 authors, Govindarajan Srimathveeralli.
Mol Ther Oncolytics, 2022 Jan 18; 24. PMID: 35036524    Free PMC article.
Conditioning treatment with CD27 Ab enhances expansion and antitumor activity of adoptively transferred T cells in mice.
Anna Wasiuk, Jeff Weidlick, +6 authors, Li-Zhen He.
Cancer Immunol Immunother, 2021 May 25; 71(1). PMID: 34028568    Free PMC article.
B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity.
Aubrey S Smith, Hannah M Knochelmann, +11 authors, Chrystal M Paulos.
J Immunother Cancer, 2022 Jan 13; 10(1). PMID: 35017148    Free PMC article.
Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice.
Pavlina Chuntova, Yafei Hou, +14 authors, Hideho Okada.
Neuro Oncol, 2021 Aug 05; 24(2). PMID: 34347086    Free PMC article.
The current landscape of immunotherapy for pediatric brain tumors.
Eugene I Hwang, Elias J Sayour, +15 authors, Ian F Pollack.
Nat Cancer, 2022 Feb 06; 3(1). PMID: 35121998
Brain capillary obstruction during neurotoxicity in a mouse model of anti-CD19 chimeric antigen receptor T-cell therapy.
Lila D Faulhaber, Anthea Q Phuong, +7 authors, Juliane Gust.
Brain Commun, 2022 Feb 17; 4(1). PMID: 35169706    Free PMC article.
The Emerging Landscape of Immune Cell Therapies.
Evan W Weber, Marcela V Maus, Crystal L Mackall.
Cell, 2020 Apr 04; 181(1). PMID: 32243795    Free PMC article.
Eradicating tumor in a recurrent cervical cancer patient with autologous tumor-infiltrating lymphocytes and a modified lymphodepleting regimen.
Jing Guo, Ning Luo, +8 authors, Zhongping Cheng.
J Immunother Cancer, 2022 Feb 19; 10(2). PMID: 35177415    Free PMC article.
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT.
Jia Wei, Min Xiao, +14 authors, Liang Huang.
Signal Transduct Target Ther, 2022 Apr 12; 7(1). PMID: 35399106    Free PMC article.
BCMA-Targeted Biologic Therapies: The Next Standard of Care in Multiple Myeloma Therapy.
Barry Paul, Cesar Rodriguez, Saad Z Usmani.
Drugs, 2022 Apr 13; 82(6). PMID: 35412114
Optimal fludarabine lymphodepletion is associated with improved outcomes after CAR T-cell therapy.
Vanessa A Fabrizio, Jaap Jan Boelens, +29 authors, Kevin J Curran.
Blood Adv, 2021 Nov 18; 6(7). PMID: 34788386    Free PMC article.
Clinical lessons learned from the first leg of the CAR T cell journey.
Robbie G Majzner, Crystal L Mackall.
Nat Med, 2019 Sep 11; 25(9). PMID: 31501612
Highly Cited. Review.
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.
Smita S Chandran, Jiaqi Ma, +19 authors, Christopher A Klebanoff.
Nat Med, 2022 Apr 29;. PMID: 35484264
Emerging Strategies in TCR-Engineered T Cells.
Fang Wei, Xiao-Xia Cheng, John Zhao Xue, Shao-An Xue.
Front Immunol, 2022 Apr 19; 13. PMID: 35432319    Free PMC article.