Journal Article
. 2005 Oct; 25(21):9543-53.
doi: 10.1128/MCB.25.21.9543-9553.2005.

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

Richard V Parry 1 Jens M Chemnitz  Kenneth A Frauwirth  Anthony R Lanfranco  Inbal Braunstein  Sumire V Kobayashi  Peter S Linsley  Craig B Thompson  James L Riley  
Affiliations
  • PMID: 16227604
  •     72 References
  •     763 citations

Abstract

CTLA-4 and PD-1 are receptors that negatively regulate T-cell activation. Ligation of both CTLA-4 and PD-1 blocked CD3/CD28-mediated upregulation of glucose metabolism and Akt activity, but each accomplished this regulation using separate mechanisms. CTLA-4-mediated inhibition of Akt phosphorylation is sensitive to okadaic acid, providing direct evidence that PP2A plays a prominent role in mediating CTLA-4 suppression of T-cell activation. In contrast, PD-1 signaling inhibits Akt phosphorylation by preventing CD28-mediated activation of phosphatidylinositol 3-kinase (PI3K). The ability of PD-1 to suppress PI3K/AKT activation was dependent upon the immunoreceptor tyrosine-based switch motif located in its cytoplasmic tail, adding further importance to this domain in mediating PD-1 signal transduction. Lastly, PD-1 ligation is more effective in suppressing CD3/CD28-induced changes in the T-cell transcriptional profile, suggesting that differential regulation of PI3K activation by PD-1 and CTLA-4 ligation results in distinct cellular phenotypes. Together, these data suggest that CTLA-4 and PD-1 inhibit T-cell activation through distinct and potentially synergistic mechanisms.

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Immunol Rev, 2010 Jul 20; 236. PMID: 20636820    Free PMC article.
Highly Cited. Review.
Update on the genetics and genomics of PBC.
Brian D Juran, Konstantinos N Lazaridis.
J Autoimmun, 2010 Jul 20; 35(3). PMID: 20638243    Free PMC article.
Review.
Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection.
Afework Kassu, Roland A Marcus, +6 authors, Brent E Palmer.
J Immunol, 2010 Jul 27; 185(5). PMID: 20656923    Free PMC article.
Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B.
Ji Chen, Xiao-Mei Wang, +4 authors, Gui-Qiang Wang.
Inflamm Res, 2010 Jul 28; 60(1). PMID: 20661763
Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.
Begoña Comin-Anduix, Hooman Sazegar, +9 authors, Antoni Ribas.
PLoS One, 2010 Sep 22; 5(9). PMID: 20856802    Free PMC article.
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Michael Quigley, Florencia Pereyra, +23 authors, W Nicholas Haining.
Nat Med, 2010 Oct 05; 16(10). PMID: 20890291    Free PMC article.
Highly Cited.
Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model.
Ping Yu, Jason C Steel, +2 authors, Thomas A Waldmann.
Clin Cancer Res, 2010 Oct 07; 16(24). PMID: 20924130    Free PMC article.
Selection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cells.
Takashi Inozume, Ken-Ichi Hanada, +4 authors, James C Yang.
J Immunother, 2010 Oct 16; 33(9). PMID: 20948441    Free PMC article.
Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection.
William W Reiley, Shahin Shafiani, +6 authors, David L Woodland.
Proc Natl Acad Sci U S A, 2010 Oct 22; 107(45). PMID: 20962277    Free PMC article.
Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii.
Anmol Chandele, Paushali Mukerjee, +2 authors, Virander S Chauhan.
Immunology, 2010 Nov 03; 132(2). PMID: 21039472    Free PMC article.
Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling.
Aimee J Marko, Rebecca A Miller, Alina Kelman, Kenneth A Frauwirth.
PLoS One, 2010 Nov 19; 5(11). PMID: 21085672    Free PMC article.
Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase.
Edwin J Vazquez-Cintron, Ngozi R Monu, Alan B Frey.
J Immunol, 2010 Dec 04; 185(12). PMID: 21127315    Free PMC article.
Review.
Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes.
R Tohn, H Blumenfeld, +4 authors, T L Delovitch.
Clin Exp Immunol, 2011 Mar 03; 164(1). PMID: 21361909    Free PMC article.
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
Arne N Akbar, Sian M Henson.
Nat Rev Immunol, 2011 Mar 26; 11(4). PMID: 21436838
Highly Cited.
Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration.
Katy Derbyshire, Caroline Addey, +7 authors, Diane M Scott.
J Immunol, 2011 Apr 15; 186(10). PMID: 21490154    Free PMC article.
Inverse correlation of programmed death 1 (PD-1) expression in T cells to the spinal radiologic changes in Taiwanese patients with ankylosing spondylitis.
Ming-Han Chen, Wei-Sheng Chen, +2 authors, Chung-Tei Chou.
Clin Rheumatol, 2011 May 07; 30(9). PMID: 21547439
PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine.
Jacalyn Rosenblatt, Brett Glotzbecker, +10 authors, David Avigan.
J Immunother, 2011 May 18; 34(5). PMID: 21577144    Free PMC article.
Highly Cited.
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Filippos Porichis, Douglas S Kwon, +9 authors, Daniel E Kaufmann.
Blood, 2011 Jun 10; 118(4). PMID: 21652684    Free PMC article.
Highly Cited.
Emerging antibody combinations in oncology.
Stephen J Demarest, Kandasamy Hariharan, Jianying Dong.
MAbs, 2011 Jun 24; 3(4). PMID: 21697653    Free PMC article.
Review.
T cell exhaustion.
E John Wherry.
Nat Immunol, 2011 Jul 09; 12(6). PMID: 21739672
Highly Cited. Review.
Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner.
T Zhang, S Fresnay, +11 authors, A M Azimzadeh.
Am J Transplant, 2011 Jul 14; 11(8). PMID: 21749640    Free PMC article.
Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis.
Scott B Ficarro, Yi Zhang, +5 authors, Jarrod A Marto.
Mol Cell Proteomics, 2011 Jul 27; 10(11). PMID: 21788404    Free PMC article.
Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells.
Nicole L Yonkers, Benigno Rodriguez, +2 authors, Donald D Anthony.
PLoS One, 2011 Sep 14; 6(9). PMID: 21912648    Free PMC article.
Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.
Julien van Grevenynghe, Rafael A Cubas, +14 authors, Elias K Haddad.
J Clin Invest, 2011 Sep 20; 121(10). PMID: 21926463    Free PMC article.
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.
Ben Youngblood, Kenneth J Oestreich, +9 authors, Rafi Ahmed.
Immunity, 2011 Sep 29; 35(3). PMID: 21943489    Free PMC article.
Highly Cited.
The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion.
Kimberly A Hofmeyer, Hyungjun Jeon, Xingxing Zang.
J Biomed Biotechnol, 2011 Oct 01; 2011. PMID: 21960736    Free PMC article.
Review.
Immunogenic and tolerogenic signatures in human immunodeficiency virus (HIV)-infected controllers compared with progressors and a conversion strategy of virus control.
T Whittall, B Peters, +3 authors, T Lehner.
Clin Exp Immunol, 2011 Oct 12; 166(2). PMID: 21985367    Free PMC article.
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma.
Xiang-Yang Wang, Daming Zuo, Devanand Sarkar, Paul B Fisher.
Expert Opin Pharmacother, 2011 Nov 15; 12(17). PMID: 22077831    Free PMC article.
Review.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Lucy S K Walker, David M Sansom.
Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087
Highly Cited.
Tumor evasion from T cell surveillance.
Katrin Töpfer, Stefanie Kempe, +5 authors, Achim Temme.
J Biomed Biotechnol, 2011 Dec 23; 2011. PMID: 22190859    Free PMC article.
Review.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Oana Draghiciu, Hans W Nijman, Toos Daemen.
Clin Dev Immunol, 2011 Dec 23; 2011. PMID: 22190971    Free PMC article.
Review.
Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade.
Sian M Henson, Richard Macaulay, Ornella Franzese, Arne N Akbar.
Immunology, 2012 Jan 04; 135(4). PMID: 22211948    Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy.
Drew Pardoll, Charles Drake.
J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682    Free PMC article.
Finding Balance: T cell Regulatory Receptor Expression during Aging.
Mary M Cavanagh, Qian Qi, Cornelia M Weyand, Jörg J Goronzy.
Aging Dis, 2012 Mar 08; 2(5). PMID: 22396890    Free PMC article.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model.
Ping Yu, Jason C Steel, +5 authors, Thomas A Waldmann.
Proc Natl Acad Sci U S A, 2012 Apr 05; 109(16). PMID: 22474386    Free PMC article.
Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells.
Adam T Waickman, Jonathan D Powell.
J Immunol, 2012 May 05; 188(10). PMID: 22556133    Free PMC article.
Review.
The role of coinhibitory signaling pathways in transplantation and tolerance.
Martina M McGrath, Nader Najafian.
Front Immunol, 2012 May 09; 3. PMID: 22566929    Free PMC article.
Programmed death ligand 2 in cancer-induced immune suppression.
Esdy N Rozali, Stanleyson V Hato, +2 authors, W Joost Lesterhuis.
Clin Dev Immunol, 2012 May 23; 2012. PMID: 22611421    Free PMC article.
Highly Cited. Review.
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Tadashi Yokosuka, Masako Takamatsu, +3 authors, Takashi Saito.
J Exp Med, 2012 May 30; 209(6). PMID: 22641383    Free PMC article.
Highly Cited.
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation.
Nikolaos Patsoukis, Julia Brown, +3 authors, Vassiliki A Boussiotis.
Sci Signal, 2012 Jun 29; 5(230). PMID: 22740686    Free PMC article.
Highly Cited.
T cell signaling targets for enhancing regulatory or effector function.
Fan Pan, Huimin Fan, Zhongmin Liu, Shuiping Jiang.
Sci Signal, 2012 Aug 03; 5(235). PMID: 22855503    Free PMC article.
mTOR, metabolism, and the regulation of T-cell differentiation and function.
Adam T Waickman, Jonathan D Powell.
Immunol Rev, 2012 Aug 15; 249(1). PMID: 22889214    Free PMC article.
Highly Cited. Review.
Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation.
Daniel R Wahl, Craig A Byersdorfer, +2 authors, Gary D Glick.
Immunol Rev, 2012 Aug 15; 249(1). PMID: 22889218    Free PMC article.
Review.
Role of the PD-1 pathway in the immune response.
L V Riella, A M Paterson, A H Sharpe, A Chandraker.
Am J Transplant, 2012 Aug 21; 12(10). PMID: 22900886    Free PMC article.
Highly Cited. Review.
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.
Jonathan M Han, Scott J Patterson, Megan K Levings.
Front Immunol, 2012 Aug 21; 3. PMID: 22905034    Free PMC article.
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines.
Weiyi Peng, Chengwen Liu, +8 authors, Patrick Hwu.
Cancer Res, 2012 Aug 24; 72(20). PMID: 22915761    Free PMC article.
Highly Cited.
MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.
Therese Liechtenstein, Ines Dufait, +2 authors, David Escors.
Immunol Endocr Metab Agents Med Chem, 2012 Sep 05; 12(3). PMID: 22945252    Free PMC article.
Thinking inside the box: how T cell inhibitory receptors signal.
W Nicholas Haining.
Nat Med, 2012 Sep 11; 18(9). PMID: 22961161
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Eric F Tewalt, Jarish N Cohen, +10 authors, Victor H Engelhard.
Blood, 2012 Sep 21; 120(24). PMID: 22993390    Free PMC article.
Highly Cited.
Immune tolerance and transplantation.
Onder Alpdogan, Marcel R M van den Brink.
Semin Oncol, 2012 Dec 05; 39(6). PMID: 23206840    Free PMC article.
Review.
Targeting PD-1/PD-L1 interactions for cancer immunotherapy.
Laurence Zitvogel, Guido Kroemer.
Oncoimmunology, 2012 Dec 18; 1(8). PMID: 23243584    Free PMC article.
Highly Cited.
Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells.
Ei Wakamatsu, Diane Mathis, Christophe Benoist.
Proc Natl Acad Sci U S A, 2013 Jan 02; 110(3). PMID: 23277554    Free PMC article.
Metabolic regulation of T lymphocytes.
Nancie J MacIver, Ryan D Michalek, Jeffrey C Rathmell.
Annu Rev Immunol, 2013 Jan 10; 31. PMID: 23298210    Free PMC article.
Highly Cited. Review.
CTLA-4 blockade in tumor models: an overview of preclinical and translational research.
Joseph F Grosso, Maria N Jure-Kunkel.
Cancer Immun, 2013 Feb 08; 13. PMID: 23390376    Free PMC article.
Highly Cited. Review.
Metabolic control of the Treg/Th17 axis.
Joseph Barbi, Drew Pardoll, Fan Pan.
Immunol Rev, 2013 Feb 15; 252(1). PMID: 23405895    Free PMC article.
Highly Cited. Review.
Structure and interactions of the human programmed cell death 1 receptor.
Xiaoxiao Cheng, Vaclav Veverka, +16 authors, Simon J Davis.
J Biol Chem, 2013 Feb 19; 288(17). PMID: 23417675    Free PMC article.
Highly Cited.
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells.
Chen Wang, Tai Yi, +5 authors, Jordan S Pober.
J Clin Invest, 2013 Mar 13; 123(4). PMID: 23478407    Free PMC article.
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer.
S A Quezada, K S Peggs.
Br J Cancer, 2013 Mar 21; 108(8). PMID: 23511566    Free PMC article.
Molecular signatures of T-cell inhibition in HIV-1 infection.
Marie Larsson, Esaki M Shankar, +5 authors, Adeeba Kamarulzaman.
Retrovirology, 2013 Mar 22; 10. PMID: 23514593    Free PMC article.
Review.
PD-1 coinhibitory signals: the link between pathogenesis and protection.
Deanna A Kulpa, Mariam Lawani, +3 authors, Rafick-Pierre Sékaly.
Semin Immunol, 2013 Apr 04; 25(3). PMID: 23548749    Free PMC article.
Review.
Understanding dendritic cells and their role in cutaneous carcinoma and cancer immunotherapy.
Valerie R Yanofsky, Hiroshi Mitsui, Diane Felsen, John A Carucci.
Clin Dev Immunol, 2013 Apr 23; 2013. PMID: 23606870    Free PMC article.
Review.
Strength of PD-1 signaling differentially affects T-cell effector functions.
Fang Wei, Shi Zhong, +6 authors, James L Riley.
Proc Natl Acad Sci U S A, 2013 Apr 24; 110(27). PMID: 23610399    Free PMC article.
Highly Cited.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.
Jaikumar Duraiswamy, Karen M Kaluza, Gordon J Freeman, George Coukos.
Cancer Res, 2013 May 02; 73(12). PMID: 23633484    Free PMC article.
Highly Cited.
Nivolumab plus ipilimumab in advanced melanoma.
Jedd D Wolchok, Harriet Kluger, +21 authors, Mario Sznol.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867    Free PMC article.
Highly Cited.
PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2.
Nikolaos Patsoukis, Lequn Li, +2 authors, Vassiliki A Boussiotis.
Mol Cell Biol, 2013 Jun 05; 33(16). PMID: 23732914    Free PMC article.
The immunological synapse: the gateway to the HIV reservoir.
Deanna A Kulpa, Jessica H Brehm, +5 authors, Rafick-Pierre Sékaly.
Immunol Rev, 2013 Jun 19; 254(1). PMID: 23772628    Free PMC article.
Review.
PD-1 regulates T cell proliferation in a tissue and subset-specific manner during normal mouse pregnancy.
Michelle T Shepard, Elizabeth A Bonney.
Immunol Invest, 2013 Jun 21; 42(5). PMID: 23782245    Free PMC article.
Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation.
Jennifer L Chain, Allison K Martin, +3 authors, Andrew P Fontenot.
J Immunol, 2013 Jul 16; 191(4). PMID: 23851684    Free PMC article.
Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.
Frederick L Locke, Yuan-yuan Zha, +2 authors, Thomas F Gajewski.
J Immunol, 2013 Jul 16; 191(4). PMID: 23851688    Free PMC article.
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.
Christopher J Nirschl, Charles G Drake.
Clin Cancer Res, 2013 Jul 23; 19(18). PMID: 23868869    Free PMC article.
Highly Cited. Review.
Beyond the antigen receptor: editing the genome of T-cells for cancer adoptive cellular therapies.
Angharad Lloyd, Owen N Vickery, Bruno Laugel.
Front Immunol, 2013 Aug 13; 4. PMID: 23935598    Free PMC article.
Role of CTLA4 in the proliferation and survival of chronic lymphocytic leukemia.
Amit K Mittal, Nagendra K Chaturvedi, +5 authors, Shantaram S Joshi.
PLoS One, 2013 Aug 13; 8(8). PMID: 23936412    Free PMC article.
The great balancing act: regulation and fate of antiviral T-cell interactions.
E Ashley Moseman, Dorian B McGavern.
Immunol Rev, 2013 Aug 21; 255(1). PMID: 23947351    Free PMC article.
Review.
B7 family checkpoint regulators in immune regulation and disease.
Sabrina Ceeraz, Elizabeth C Nowak, Randolph J Noelle.
Trends Immunol, 2013 Aug 21; 34(11). PMID: 23954143    Free PMC article.
Highly Cited. Review.
Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer.
Jaikumar Duraiswamy, Gordon J Freeman, George Coukos.
Cancer Res, 2013 Aug 27; 73(23). PMID: 23975756    Free PMC article.
Highly Cited.
Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.
Asim Saha, Kazutoshi Aoyama, +15 authors, Bruce R Blazar.
Blood, 2013 Sep 14; 122(17). PMID: 24030385    Free PMC article.
Highly Cited.
Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis.
Tao Zhang, Wenjie Guo, +11 authors, Qiang Xu.
Sci Rep, 2013 Oct 04; 3. PMID: 24088816    Free PMC article.
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Jeffrey S Weber, Ragini Reiney Kudchadkar, +11 authors, Y Ann Chen.
J Clin Oncol, 2013 Oct 23; 31(34). PMID: 24145345    Free PMC article.
Highly Cited.
Immunotherapy and immune evasion in prostate cancer.
Archana Thakur, Ulka Vaishampayan, Lawrence G Lum.
Cancers (Basel), 2013 Nov 13; 5(2). PMID: 24216992    Free PMC article.
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.
Taku Okazaki, Shunsuke Chikuma, +2 authors, Tasuku Honjo.
Nat Immunol, 2013 Nov 19; 14(12). PMID: 24240160
Highly Cited. Review.
The molecular study of IFNβ pleiotropic roles in MS treatment.
Maryam Kay, Zohreh Hojati, Fariba Dehghanian.
Iran J Neurol, 2013 Nov 20; 12(4). PMID: 24250925    Free PMC article.
Review.
T-cell costimulatory blockade in organ transplantation.
Jonathan S Maltzman, Laurence A Turka.
Cold Spring Harb Perspect Med, 2013 Dec 04; 3(12). PMID: 24296352    Free PMC article.
Review.
Neuroinflammation and brain functional disconnection in Alzheimer's disease.
Francesca Baglio, Marina Saresella, +7 authors, Mario Clerici.
Front Aging Neurosci, 2013 Dec 11; 5. PMID: 24324435    Free PMC article.
PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.
Victor D Fedorov, Maria Themeli, Michel Sadelain.
Sci Transl Med, 2013 Dec 18; 5(215). PMID: 24337479    Free PMC article.
Highly Cited.
Effects of costimulation on intrahepatic immunopathogenesis in patients with chronic HBV infection.
Bei Zhong, Mao Ping Huang, Guo Qing Yin, Xiang Gao.
Inflamm Res, 2013 Dec 18; 63(3). PMID: 24337678    Free PMC article.
TLR2 directing PD-L2 expression inhibit T cells response in Schistosoma japonicum infection.
Yanan Gao, Lin Chen, +4 authors, Guanling Wu.
PLoS One, 2014 Jan 01; 8(12). PMID: 24376539    Free PMC article.
Mitigating the toxic effects of anticancer immunotherapy.
Tara C Gangadhar, Robert H Vonderheide.
Nat Rev Clin Oncol, 2014 Jan 22; 11(2). PMID: 24445516
Highly Cited. Review.
Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.
Franz J Gassner, Nadja Zaborsky, +8 authors, Roland Geisberger.
Haematologica, 2014 Feb 25; 99(5). PMID: 24561794    Free PMC article.
The strength of the T cell response against a surrogate tumor antigen induced by oncolytic VSV therapy does not correlate with tumor control.
Valérie Janelle, Marie-Pierre Langlois, +3 authors, Alain Lamarre.
Mol Ther, 2014 Mar 05; 22(6). PMID: 24590047    Free PMC article.
Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies.
Agnieszka Anna Rucki, Lei Zheng.
World J Gastroenterol, 2014 Mar 08; 20(9). PMID: 24605023    Free PMC article.
Review.
Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy.
Maxine Bauzon, Terry Hermiston.
Front Immunol, 2014 Mar 08; 5. PMID: 24605114    Free PMC article.
Review.
Metabolic regulation of immune responses.
Kirthana Ganeshan, Ajay Chawla.
Annu Rev Immunol, 2014 Mar 25; 32. PMID: 24655299    Free PMC article.
Highly Cited. Review.
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.
Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641    Free PMC article.
Highly Cited.
Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy.
Thomas E Stinchcombe.
Med Oncol, 2014 Apr 22; 31(5). PMID: 24748366    Free PMC article.
Review.
Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized mice.
Chelsea M Black, Todd D Armstrong, Elizabeth M Jaffee.
Cancer Immunol Res, 2014 Apr 26; 2(4). PMID: 24764578    Free PMC article.
Immunotherapy for brain cancer: recent progress and future promise.
Christopher M Jackson, Michael Lim, Charles G Drake.
Clin Cancer Res, 2014 Apr 29; 20(14). PMID: 24771646    Free PMC article.
Review.
Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates.
Francesca Avogadri, Roberta Zappasodi, +8 authors, Taha Merghoub.
Cancer Immunol Res, 2014 May 06; 2(5). PMID: 24795357    Free PMC article.
A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China.
Cuiping Liu, Juean Jiang, +6 authors, Xueguang Zhang.
Int J Genomics, 2014 May 08; 2014. PMID: 24804191    Free PMC article.
Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma.
Mohammad Atefi, Earl Avramis, +9 authors, Antoni Ribas.
Clin Cancer Res, 2014 May 09; 20(13). PMID: 24812408    Free PMC article.
Highly Cited.
Anti-PD-1 antibody significantly increases therapeutic efficacy of Listeria monocytogenes (Lm)-LLO immunotherapy.
Mikayel Mkrtichyan, Namju Chong, +4 authors, Samir N Khleif.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829751    Free PMC article.
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
Mary B Mockler, Melissa J Conroy, Joanne Lysaght.
Front Oncol, 2014 Jun 07; 4. PMID: 24904823    Free PMC article.
Review.
Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time.
Julita Kaczmarek, Yahya Homsi, +5 authors, Linda Diehl.
PLoS One, 2014 Jun 14; 9(6). PMID: 24924593    Free PMC article.
Enhancing effect of glucose microspheres in the viability of human mesenchymal stem cell suspensions for clinical administration.
Patricia Gálvez, Maria J Martín, +3 authors, Beatriz Clares.
Pharm Res, 2014 Jun 26; 31(12). PMID: 24962511
The effect of adjuvanting cancer vaccines with herpes simplex virus glycoprotein D on melanoma-driven CD8+ T cell exhaustion.
Ying Zhang, Hildegund C J Ertl.
J Immunol, 2014 Jul 16; 193(4). PMID: 25024391    Free PMC article.
Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus.
Nandini Sen, Gourab Mukherjee, +4 authors, Ann M Arvin.
Cell Rep, 2014 Jul 22; 8(2). PMID: 25043183    Free PMC article.
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Lunxian Tang, Jianwen Bai, +4 authors, Alfred Ayala.
J Leukoc Biol, 2014 Aug 02; 96(5). PMID: 25082151    Free PMC article.
Biochemical signaling of PD-1 on T cells and its functional implications.
Vassiliki A Boussiotis, Pranam Chatterjee, Lequn Li.
Cancer J, 2014 Aug 08; 20(4). PMID: 25098287    Free PMC article.
Review.
Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.
Sheetal Bodhankar, Yingxin Chen, +3 authors, Halina Offner.
Front Cell Neurosci, 2014 Aug 27; 8. PMID: 25157219    Free PMC article.
Antibody-based immunotherapy for malignant glioma.
Patrick C Gedeon, Katherine A Riccione, Peter E Fecci, John H Sampson.
Semin Oncol, 2014 Sep 01; 41(4). PMID: 25173142    Free PMC article.
Review.
Cancer immunotherapy in clinical practice -- the past, present, and future.
Gaurav Goel, Weijing Sun.
Chin J Cancer, 2014 Sep 06; 33(9). PMID: 25189717    Free PMC article.
Imbalance of circulating monocyte subsets and PD-1 dysregulation in Q fever endocarditis: the role of IL-10 in PD-1 modulation.
Mignane B Ka, Françoise Gondois-Rey, +5 authors, Jean-Louis Mege.
PLoS One, 2014 Sep 12; 9(9). PMID: 25211350    Free PMC article.
Immune modulation for cancer therapy.
J Naidoo, D B Page, J D Wolchok.
Br J Cancer, 2014 Sep 12; 111(12). PMID: 25211661    Free PMC article.
Review.
The programmed death-1 immune-suppressive pathway: barrier to antitumor immunity.
Suzanne Ostrand-Rosenberg, Lucas A Horn, Samuel T Haile.
J Immunol, 2014 Oct 05; 193(8). PMID: 25281753    Free PMC article.
Highly Cited. Review.
Dendritic cell cancer vaccines: from the bench to the bedside.
Tamar Katz, Irit Avivi, +2 authors, David Avigan.
Rambam Maimonides Med J, 2014 Nov 12; 5(4). PMID: 25386340    Free PMC article.
Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway.
Kim C Ohaegbulam, Amer Assal, +2 authors, Xingxing Zang.
Trends Mol Med, 2014 Dec 03; 21(1). PMID: 25440090    Free PMC article.
Highly Cited. Review.
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.
Matthew M Staron, Simon M Gray, +6 authors, Susan M Kaech.
Immunity, 2014 Dec 04; 41(5). PMID: 25464856    Free PMC article.
Highly Cited.
Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway.
Parisa Momtaz, Michael A Postow.
Pharmgenomics Pers Med, 2014 Dec 09; 7. PMID: 25484597    Free PMC article.
Review.
Novel immunotherapies for hematologic malignancies.
Michelle H Nelson, Chrystal M Paulos.
Immunol Rev, 2014 Dec 17; 263(1). PMID: 25510273    Free PMC article.
Review.
Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8+ T cells.
Melissa M Berrien-Elliott, Jinyun Yuan, +4 authors, Ryan M Teague.
Cancer Immunol Res, 2014 Dec 18; 3(2). PMID: 25516478    Free PMC article.
Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.
Helga Schneider, Christopher E Rudd.
Front Immunol, 2014 Dec 30; 5. PMID: 25538704    Free PMC article.
Review.
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo.
Rituparna Das, Rakesh Verma, +8 authors, Kavita M Dhodapkar.
J Immunol, 2014 Dec 30; 194(3). PMID: 25539810    Free PMC article.
Highly Cited.
Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.
Rhoanne C McPherson, Joanne E Konkel, +10 authors, Stephen M Anderton.
Elife, 2014 Dec 30; 3. PMID: 25546306    Free PMC article.
The role of Fatty Acid oxidation in the metabolic reprograming of activated t-cells.
Craig Alan Byersdorfer.
Front Immunol, 2015 Jan 08; 5. PMID: 25566254    Free PMC article.
Review.
Confusing signals: recent progress in CTLA-4 biology.
Lucy S K Walker, David M Sansom.
Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039    Free PMC article.
Highly Cited. Review.
Understanding HIV latency: the road to an HIV cure.
Matthew S Dahabieh, Emilie Battivelli, Eric Verdin.
Annu Rev Med, 2015 Jan 15; 66. PMID: 25587657    Free PMC article.
Highly Cited. Review.
Targeting T cell metabolism for therapy.
David O'Sullivan, Erika L Pearce.
Trends Immunol, 2015 Jan 21; 36(2). PMID: 25601541    Free PMC article.
Highly Cited. Review.
Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation.
Mohamed El-Far, Petronela Ancuta, +14 authors, Rafick-Pierre Sékaly.
J Gen Virol, 2015 Jan 30; 96(Pt 6). PMID: 25626682    Free PMC article.
Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis.
Michael Peled, Marianne Strazza, +3 authors, Adam Mor.
Inflammation, 2015 Feb 11; 38(4). PMID: 25663558
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.
Sérgio T Ribeiro, Julie C Ribot, Bruno Silva-Santos.
Front Immunol, 2015 Feb 13; 6. PMID: 25674089    Free PMC article.
Review.
Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.
R Fujisawa, F Haseda, +8 authors, T Hanafusa.
Clin Exp Immunol, 2015 Feb 17; 180(3). PMID: 25682896    Free PMC article.
Elevation of Tim-3 and PD-1 expression on T cells appears early in HIV infection, and differential Tim-3 and PD-1 expression patterns can be induced by common γ -chain cytokines.
Zi-Ning Zhang, Ming-Lu Zhu, +5 authors, Hong Shang.
Biomed Res Int, 2015 Feb 17; 2015. PMID: 25685816    Free PMC article.
An update on current management of advanced renal cell cancer, biomarkers, and future directions.
Wanqing Iris Zhi, Jenny J Kim.
Ann Cancer Res, 2015 Feb 28; 1(2). PMID: 25722991    Free PMC article.
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal.
Stefanie N Linch, Michael J McNamara, William L Redmond.
Front Oncol, 2015 Mar 13; 5. PMID: 25763356    Free PMC article.
Highly Cited. Review.
T cell metabolic fitness in antitumor immunity.
Peter J Siska, Jeffrey C Rathmell.
Trends Immunol, 2015 Mar 17; 36(4). PMID: 25773310    Free PMC article.
Highly Cited. Review.
Overcoming T cell exhaustion in infection and cancer.
Kristen E Pauken, E John Wherry.
Trends Immunol, 2015 Mar 24; 36(4). PMID: 25797516    Free PMC article.
Highly Cited. Review.
The Role of Anti-PD-1/PD-L1 Agents in Melanoma: Progress to Date.
Katy K Tsai, Adil I Daud.
Drugs, 2015 Mar 25; 75(6). PMID: 25802230
Review.
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.
Nikolaos Patsoukis, Kankana Bardhan, +9 authors, Vassiliki A Boussiotis.
Nat Commun, 2015 Mar 27; 6. PMID: 25809635    Free PMC article.
Highly Cited.
PD-1/PD-L1 expression on CD(4+) T cells and myeloid DCs correlates with the immune pathogenesis of atrial fibrillation.
Li Liu, Qiangsun Zheng, +3 authors, Zhiquan Wang.
J Cell Mol Med, 2015 Mar 27; 19(6). PMID: 25810125    Free PMC article.
NF-κB regulates PD-1 expression in macrophages.
Alexander P R Bally, Peiyuan Lu, +4 authors, Jeremy M Boss.
J Immunol, 2015 Mar 27; 194(9). PMID: 25810391    Free PMC article.
Endothelial cell metabolism in normal and diseased vasculature.
Guy Eelen, Pauline de Zeeuw, Michael Simons, Peter Carmeliet.
Circ Res, 2015 Mar 31; 116(7). PMID: 25814684    Free PMC article.
Highly Cited. Review.
Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.
Xinxin Wang, Leonard Benjamin Hills, Yina Hsing Huang.
Front Immunol, 2015 Mar 31; 6. PMID: 25821452    Free PMC article.
Review.
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma.
Kathleen M Mahoney, Gordon J Freeman, David F McDermott.
Clin Ther, 2015 Apr 01; 37(4). PMID: 25823918    Free PMC article.
Highly Cited. Review.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells.
Ji Sung Kim, Yong Guk Kim, +4 authors, Sang-Bae Han.
Immune Netw, 2015 Apr 30; 15(2). PMID: 25922594    Free PMC article.
Review.
In vivo RNAi screens: concepts and applications.
Shane Crotty, Matthew E Pipkin.
Trends Immunol, 2015 May 06; 36(5). PMID: 25937561    Free PMC article.
Review.
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.
Robert D Leone, Ying-Chun Lo, Jonathan D Powell.
Comput Struct Biotechnol J, 2015 May 06; 13. PMID: 25941561    Free PMC article.
Highly Cited. Review.
Clinical applications of PD-1-based therapy: a focus on pembrolizumab (MK-3475) in the management of melanoma and other tumor types.
Tara C Gangadhar, April Ks Salama.
Onco Targets Ther, 2015 May 12; 8. PMID: 25960664    Free PMC article.
Review.
Programmed death-1 controls T cell survival by regulating oxidative metabolism.
Victor Tkachev, Stefanie Goodell, +5 authors, Craig A Byersdorfer.
J Immunol, 2015 May 15; 194(12). PMID: 25972478    Free PMC article.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Review.
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells.
Pamela M Odorizzi, Kristen E Pauken, +2 authors, E John Wherry.
J Exp Med, 2015 Jun 03; 212(7). PMID: 26034050    Free PMC article.
Highly Cited.
Programmed death-1 checkpoint blockade in acute myeloid leukemia.
Alison Sehgal, Theresa L Whiteside, Michael Boyiadzis.
Expert Opin Biol Ther, 2015 Jun 04; 15(8). PMID: 26036819    Free PMC article.
Review.
T-cell exhaustion in the tumor microenvironment.
Y Jiang, Y Li, B Zhu.
Cell Death Dis, 2015 Jun 19; 6. PMID: 26086965    Free PMC article.
Highly Cited. Review.
New immunotherapies targeting the PD-1 pathway.
Jordan M Chinai, Murali Janakiram, +3 authors, Xingxing Zang.
Trends Pharmacol Sci, 2015 Jul 15; 36(9). PMID: 26162965    Free PMC article.
Review.
Immunopathogenesis of hepatitis B persistent infection: implications for immunotherapeutic strategies.
Yasuteru Kondo, Yoshiyuki Ueno, Tooru Shimosegawa.
Clin J Gastroenterol, 2009 Apr 01; 2(2). PMID: 26192169
Evolving synergistic combinations of targeted immunotherapies to combat cancer.
Ignacio Melero, David M Berman, +3 authors, John Haanen.
Nat Rev Cancer, 2015 Jul 25; 15(8). PMID: 26205340
Highly Cited. Review.
Molecular and cellular insights into T cell exhaustion.
E John Wherry, Makoto Kurachi.
Nat Rev Immunol, 2015 Jul 25; 15(8). PMID: 26205583    Free PMC article.
Highly Cited. Review.
Combination cancer immunotherapy and new immunomodulatory targets.
Kathleen M Mahoney, Paul D Rennert, Gordon J Freeman.
Nat Rev Drug Discov, 2015 Aug 01; 14(8). PMID: 26228759
Highly Cited. Review.
Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion.
Greg M Delgoffe, Jonathan D Powell.
Mol Immunol, 2015 Aug 11; 68(2 Pt C). PMID: 26256793    Free PMC article.
Review.
T cell metabolic reprogramming and plasticity.
Maria Slack, Tingting Wang, Ruoning Wang.
Mol Immunol, 2015 Aug 19; 68(2 Pt C). PMID: 26277274    Free PMC article.
Review.
HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade.
David M Woods, Andressa L Sodré, +3 authors, Jeffrey Weber.
Cancer Immunol Res, 2015 Aug 25; 3(12). PMID: 26297712    Free PMC article.
Highly Cited.
The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients.
Xinbing Sui, Junhong Ma, +5 authors, Li Zhang.
Oncotarget, 2015 Aug 26; 6(23). PMID: 26305724    Free PMC article.
Review.
Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity.
Yanhong Wu, Zhenling Deng, +2 authors, Yu-Qian Zhang.
BMC Cancer, 2015 Aug 28; 15. PMID: 26310246    Free PMC article.
PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups.
Lars Henning Schmidt, Andreas Kümmel, +13 authors, Wolfgang Hartmann.
PLoS One, 2015 Aug 28; 10(8). PMID: 26313362    Free PMC article.
Highly Cited.
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.
Chih-Hao Chang, Jing Qiu, +11 authors, Erika L Pearce.
Cell, 2015 Sep 01; 162(6). PMID: 26321679    Free PMC article.
Highly Cited.
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ping-Chih Ho, Jessica Dauz Bihuniak, +15 authors, Susan M Kaech.
Cell, 2015 Sep 01; 162(6). PMID: 26321681    Free PMC article.
Highly Cited.
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade.
Elizabeth Buchbinder, F Stephen Hodi.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034    Free PMC article.
Review.
The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4(+) T-cells.
Nitasha A Kumar, Karey Cheong, +5 authors, Paul U Cameron.
Retrovirology, 2015 Sep 13; 12. PMID: 26362311    Free PMC article.
Expression of PD-1 Molecule on Regulatory T Lymphocytes in Patients with Insulin-Dependent Diabetes Mellitus.
Valentina Perri, Benedetta Russo, +5 authors, Alessandra Fierabracci.
Int J Mol Sci, 2015 Sep 24; 16(9). PMID: 26393578    Free PMC article.
New developments in the management of advanced melanoma - role of pembrolizumab.
Giuseppina Improta, Isabella Leone, +3 authors, Filippo Fraggetta.
Onco Targets Ther, 2015 Sep 24; 8. PMID: 26396529    Free PMC article.
Review.
Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies.
Yi Xia, L Jeffrey Medeiros, Ken H Young.
Biochim Biophys Acta, 2015 Oct 04; 1865(1). PMID: 26432723    Free PMC article.
Review.
Immunotherapy for advanced gastric and esophageal cancer: preclinical rationale and ongoing clinical investigations.
Alexander G Raufi, Samuel J Klempner.
J Gastrointest Oncol, 2015 Oct 22; 6(5). PMID: 26487950    Free PMC article.
Review.
TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.
Brian Tomkowicz, Eileen Walsh, +9 authors, Timothy McCabe.
PLoS One, 2015 Oct 23; 10(10). PMID: 26492563    Free PMC article.
Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.
Roybel R Ramiscal, Ian A Parish, +15 authors, Vicki Athanasopoulos.
Elife, 2015 Oct 27; 4. PMID: 26496200    Free PMC article.
Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens.
Alizée J Grimm, Stephan Kontos, +2 authors, Jeffrey A Hubbell.
Sci Rep, 2015 Oct 30; 5. PMID: 26511151    Free PMC article.
Novel immunotherapies in lymphoid malignancies.
Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes.
Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683    Free PMC article.
Highly Cited. Review.
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition.
Elizabeth I Buchbinder, Anupam Desai.
Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876    Free PMC article.
Highly Cited. Review.
Temporal protein expression pattern in intracellular signalling cascade during T-cell activation: a computational study.
Piyali Ganguli, Saikat Chowdhury, Rupa Bhowmick, Ram Rup Sarkar.
J Biosci, 2015 Nov 14; 40(4). PMID: 26564978
PD-1 Blunts the Function of Ovarian Tumor-Infiltrating Dendritic Cells by Inactivating NF-κB.
Lavakumar Karyampudi, Purushottam Lamichhane, +10 authors, Keith L Knutson.
Cancer Res, 2015 Nov 15; 76(2). PMID: 26567141    Free PMC article.
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors.
Karishma R Rajani, Richard G Vile.
Viruses, 2015 Nov 19; 7(11). PMID: 26580645    Free PMC article.
Review.
Pharmacogenomics: Biomarker-Directed Therapy for Bladder Cancer.
Robert T Jones, Kenneth M Felsenstein, Dan Theodorescu.
Urol Clin North Am, 2015 Nov 29; 43(1). PMID: 26614030    Free PMC article.
Review.
Dengue NS1 antigen contributes to disease severity by inducing interleukin (IL)-10 by monocytes.
T N Adikari, L Gomes, +6 authors, G N Malavige.
Clin Exp Immunol, 2015 Dec 02; 184(1). PMID: 26621477    Free PMC article.
Programmed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor-beta role.
Mariacarmela Santarpia, María González-Cao, +3 authors, Rafael Rosell.
Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798582    Free PMC article.
Review.
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia.
Joseph A Fraietta, Kyle A Beckwith, +24 authors, Marcela V Maus.
Blood, 2016 Jan 28; 127(9). PMID: 26813675    Free PMC article.
Highly Cited.
How Cancers Escape Immune Destruction and Mechanisms of Action for the New Significantly Active Immune Therapies: Helping Nonimmunologists Decipher Recent Advances.
Jonathan L Messerschmidt, George C Prendergast, Gerald L Messerschmidt.
Oncologist, 2016 Feb 03; 21(2). PMID: 26834161    Free PMC article.
Review.
Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis.
Madison Black, Ivraym B Barsoum, +7 authors, Charles H Graham.
Oncotarget, 2016 Feb 10; 7(9). PMID: 26859684    Free PMC article.
Highly Cited.
Basics of PD-1 in self-tolerance, infection, and cancer immunity.
Shunsuke Chikuma.
Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303
Review.
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium.
Eileen S Kim, Jennifer E Kim, +3 authors, Michael Lim.
J Immunol Res, 2016 Feb 18; 2016. PMID: 26881264    Free PMC article.
Review.
Metabolic communication in tumors: a new layer of immunoregulation for immune evasion.
Ping-Chih Ho, Pu-Ste Liu.
J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885366    Free PMC article.
Review.
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
Alison Taylor, James A Harker, +3 authors, Christopher E Rudd.
Immunity, 2016 Feb 18; 44(2). PMID: 26885856    Free PMC article.
Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression.
Ying Zhang, Hildegund C J Ertl.
Front Immunol, 2016 Feb 24; 7. PMID: 26904023    Free PMC article.
Review.
Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors.
Ying Zhang, Hildegund C J Ertl.
Oncotarget, 2016 Mar 05; 7(17). PMID: 26943036    Free PMC article.
Signaling in T cells - is anything the m(a)TOR with the picture(s)?
Mark Boothby.
F1000Res, 2016 Mar 08; 5. PMID: 26949528    Free PMC article.
Review.
Vaccines for established cancer: overcoming the challenges posed by immune evasion.
Sjoerd H van der Burg, Ramon Arens, +2 authors, Cornelis J M Melief.
Nat Rev Cancer, 2016 Mar 12; 16(4). PMID: 26965076
Highly Cited. Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Metabolism Is Central to Tolerogenic Dendritic Cell Function.
Wen Jing Sim, Patricia Jennifer Ahl, John Edward Connolly.
Mediators Inflamm, 2016 Mar 17; 2016. PMID: 26980944    Free PMC article.
Review.
The Role of γδ T Cells in Systemic Lupus Erythematosus.
Meng Wu, Jinhua Yang, Xiaofeng Li, Junwei Chen.
J Immunol Res, 2016 Mar 17; 2016. PMID: 26981547    Free PMC article.
Review.
Emerging therapeutic targets in metastatic progression: A focus on breast cancer.
Zhuo Li, Yibin Kang.
Pharmacol Ther, 2016 Mar 24; 161. PMID: 27000769    Free PMC article.
Review.
Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents.
Mauro Corrado, Luca Scorrano, Silvia Campello.
Oncotarget, 2016 Apr 16; 7(29). PMID: 27083002    Free PMC article.
Review.
Emerging therapeutic targets in esophageal adenocarcinoma.
Puja Gaur, Clayton R Hunt, Tej K Pandita.
Oncotarget, 2016 Apr 23; 7(30). PMID: 27102294    Free PMC article.
Review.
Immune Checkpoint Therapies in Prostate Cancer.
Sangeeta Goswami, Ana Aparicio, Sumit K Subudhi.
Cancer J, 2016 Apr 26; 22(2). PMID: 27111907    Free PMC article.
Review.
PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity.
Tong Seng Lim, Valerie Chew, +4 authors, Paola Ricciardi-Castagnoli.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141339    Free PMC article.
Pembrolizumab in classical Hodgkin's lymphoma.
Joseph Maly, Lapo Alinari.
Eur J Haematol, 2016 May 06; 97(3). PMID: 27147112    Free PMC article.
Review.
Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona, Eleftherios P Diamandis, Ivan M Blasutig.
BMC Med, 2016 May 07; 14. PMID: 27151159    Free PMC article.
Highly Cited. Review.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.
Daniel E Lowther, Brittany A Goods, +10 authors, David A Hafler.
JCI Insight, 2016 May 18; 1(5). PMID: 27182555    Free PMC article.
Highly Cited.
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Frank A Schildberg, Sarah R Klein, Gordon J Freeman, Arlene H Sharpe.
Immunity, 2016 May 19; 44(5). PMID: 27192563    Free PMC article.
Highly Cited. Review.
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease.
John Attanasio, E John Wherry.
Immunity, 2016 May 19; 44(5). PMID: 27192569    Free PMC article.
Highly Cited. Review.
Checkpoint Inhibitors and Other Immune Therapies for Hodgkin and Non-Hodgkin Lymphoma.
Eri Matsuki, Anas Younes.
Curr Treat Options Oncol, 2016 May 20; 17(6). PMID: 27193488    Free PMC article.
Review.
Progress and challenges for treating Type 1 diabetes.
Justin W Garyu, Eric Meffre, Chris Cotsapas, Kevan C Herold.
J Autoimmun, 2016 May 24; 71. PMID: 27210268    Free PMC article.
Review.
Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway.
Rong Wang, Aizhang Xu, +4 authors, Jim Xiang.
Cell Mol Immunol, 2016 Jun 07; 14(6). PMID: 27264687    Free PMC article.
The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats.
Mei Tian, Yonghong Zhang, +3 authors, Aihua Liao.
Sci Rep, 2016 Jun 10; 6. PMID: 27277012    Free PMC article.
Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.
Jiazhu Wu, Xiaojing Xu, +15 authors, Huidong Shi.
Oncotarget, 2016 Oct 26; 7(26). PMID: 27302925    Free PMC article.
The role of pembrolizumab in the treatment of advanced non-small cell lung cancer.
Giuseppe Santabarbara, Paolo Maione, +2 authors, Cesare Gridelli.
Ann Transl Med, 2016 Jul 08; 4(11). PMID: 27386489    Free PMC article.
Review.
Early changes in the metabolic profile of activated CD8(+) T cells.
Clemens Cammann, Alexander Rath, +5 authors, Jonathan A Lindquist.
BMC Cell Biol, 2016 Jul 09; 17(1). PMID: 27387758    Free PMC article.
Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis.
Patrícia Reis de Souza, Helioswilton Sales-Campos, +7 authors, Cristina Ribeiro de Barros Cardoso.
Mediators Inflamm, 2016 Jul 13; 2016. PMID: 27403034    Free PMC article.
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.
Baihao Zhang, Shunsuke Chikuma, +2 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2016 Jul 14; 113(30). PMID: 27410049    Free PMC article.
Highly Cited.
Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.
Ornella Franzese, Belinda Palermo, +6 authors, Paola Nisticò.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467927    Free PMC article.
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.
Bertram Bengsch, Andy L Johnson, +8 authors, E John Wherry.
Immunity, 2016 Aug 09; 45(2). PMID: 27496729    Free PMC article.
Highly Cited.
Clinical significance of T cell metabolic reprogramming in cancer.
Christoph Herbel, Nikolaos Patsoukis, +3 authors, Vassiliki A Boussiotis.
Clin Transl Med, 2016 Aug 12; 5(1). PMID: 27510264    Free PMC article.
Review.
Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
Peter J Siska, Gerritje J W van der Windt, +6 authors, Jeffrey C Rathmell.
J Immunol, 2016 Aug 12; 197(6). PMID: 27511728    Free PMC article.
Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?
Michiel van der Vlist, Jurgen Kuball, Timothy R D Radstake, Linde Meyaard.
Nat Rev Rheumatol, 2016 Aug 20; 12(10). PMID: 27539666
Review.
The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance.
Peter P Ruvolo.
BBA Clin, 2016 Aug 25; 6. PMID: 27556014    Free PMC article.
Highly Cited. Review.
Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation.
Lindsay J Celada, Joseph E Rotsinger, +4 authors, Wonder P Drake.
Am J Respir Cell Mol Biol, 2016 Aug 27; 56(1). PMID: 27564547    Free PMC article.
Functional exhaustion of CD4+ T cells induced by co-stimulatory signals from myeloid leukaemia cells.
Didem Ozkazanc, Digdem Yoyen-Ermis, +2 authors, Gunes Esendagli.
Immunology, 2016 Nov 05; 149(4). PMID: 27565576    Free PMC article.
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
Mark J Selby, John J Engelhardt, +11 authors, Alan J Korman.
PLoS One, 2016 Sep 10; 11(9). PMID: 27610613    Free PMC article.
Highly Cited.
Blockade of programmed death-1/programmed death ligand pathway enhances the antitumor immunity of human invariant natural killer T cells.
Toshiko Kamata, Akane Suzuki, +10 authors, Shinichiro Motohashi.
Cancer Immunol Immunother, 2016 Sep 16; 65(12). PMID: 27631416    Free PMC article.
Virotherapy: cancer gene therapy at last?
Alan E Bilsland, Pavlina Spiliopoulou, T R Jeffry Evans.
F1000Res, 2016 Sep 17; 5. PMID: 27635234    Free PMC article.
Review.
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma.
Asma Beldi-Ferchiou, Marion Lambert, +10 authors, Sophie Caillat-Zucman.
Oncotarget, 2016 Sep 24; 7(45). PMID: 27662664    Free PMC article.
Highly Cited.
Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression.
Lindsay C Davies, Nina Heldring, Nadir Kadri, Katarina Le Blanc.
Stem Cells, 2016 Oct 27; 35(3). PMID: 27671847    Free PMC article.
Highly Cited.
PD-1 expression on the surface of peripheral blood CD4+ T cell and its association with the prognosis of patients with diffuse large B-cell lymphoma.
Wei Zhang, Jie-Fei Bai, +6 authors, Dao-Bin Zhou.
Cancer Med, 2016 Oct 07; 5(11). PMID: 27709793    Free PMC article.
Nutrients and the microenvironment to feed a T cell army.
Marc O Johnson, Peter J Siska, Diana C Contreras, Jeffrey C Rathmell.
Semin Immunol, 2016 Oct 08; 28(5). PMID: 27712958    Free PMC article.
Review.
Dynamic Metabolism in Immune Response.
Mazen Al-Hommrani, Paramita Chakraborty, Shilpak Chatterjee, Shikhar Mehrotra.
J Immunol Res Ther, 2016 Oct 25; 1(1). PMID: 27774525    Free PMC article.
Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer.
Matthew J Riese, Edmund K Moon, Bryon D Johnson, Steven M Albelda.
Front Cell Dev Biol, 2016 Nov 02; 4. PMID: 27800476    Free PMC article.
Review.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.
Vassiliki A Boussiotis.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234    Free PMC article.
Highly Cited. Review.
Emerging strategies for the treatment of advanced small cell lung cancer.
Joline S J Lim, Dearbhaile Collins, Timothy A Yap.
J Thorac Dis, 2016 Nov 22; 8(10). PMID: 27867600    Free PMC article.
The emerging role of immune checkpoint inhibition in malignant lymphoma.
Ida Hude, Stephanie Sasse, Andreas Engert, Paul J Bröckelmann.
Haematologica, 2016 Nov 26; 102(1). PMID: 27884973    Free PMC article.
Review.
Age-related changes in the gene expression profile of antigen-specific mouse CD8+ T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination.
Noor Dawany, Elizabeth M Parzych, Louise C Showe, Hildegund Cj Ertl.
Aging (Albany NY), 2016 Dec 07; 8(12). PMID: 27922818    Free PMC article.
PD-1/PD-L pathway inhibits M.tb-specific CD4+ T-cell functions and phagocytosis of macrophages in active tuberculosis.
Lei Shen, Yan Gao, +7 authors, Lingyun Shao.
Sci Rep, 2016 Dec 08; 6. PMID: 27924827    Free PMC article.
Osteosarcoma Overview.
Brock A Lindsey, Justin E Markel, Eugenie S Kleinerman.
Rheumatol Ther, 2016 Dec 10; 4(1). PMID: 27933467    Free PMC article.
Highly Cited. Review.
Potent CD4+ T cell-associated antitumor memory responses induced by trifunctional bispecific antibodies in combination with immune checkpoint inhibition.
Nina Deppisch, Peter Ruf, +2 authors, Ralph Mocikat.
Oncotarget, 2016 Dec 15; 8(3). PMID: 27966460    Free PMC article.
PD-1 and its ligands are important immune checkpoints in cancer.
Yinan Dong, Qian Sun, Xinwei Zhang.
Oncotarget, 2016 Dec 16; 8(2). PMID: 27974689    Free PMC article.
Highly Cited. Review.
Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer.
J C Osorio, A Ni, +11 authors, M D Hellmann.
Ann Oncol, 2016 Dec 22; 28(3). PMID: 27998967    Free PMC article.
Highly Cited.
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation.
Kankana Bardhan, Theodora Anagnostou, Vassiliki A Boussiotis.
Front Immunol, 2016 Dec 27; 7. PMID: 28018338    Free PMC article.
Highly Cited. Review.
Update on immune checkpoint inhibitors in gynecological cancers.
Valerie Heong, Natalie Ngoi, David Shao Peng Tan.
J Gynecol Oncol, 2016 Dec 29; 28(2). PMID: 28028993    Free PMC article.
Review.
TILs in Head and Neck Cancer: Ready for Clinical Implementation and Why (Not)?
Astrid De Meulenaere, Tijl Vermassen, +3 authors, Liesbeth Ferdinande.
Head Neck Pathol, 2016 Dec 30; 11(3). PMID: 28032290    Free PMC article.
Review.
A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy.
Erhao Zhang, Hanmei Xu.
J Hematol Oncol, 2017 Jan 05; 10(1). PMID: 28049484    Free PMC article.
Highly Cited. Review.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger.
Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373    Free PMC article.
Highly Cited. Review.
Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression.
Patrizia Mondello, Salvatore Cuzzocrea, Michele Navarra, Michael Mian.
Oncotarget, 2017 Jan 19; 8(12). PMID: 28099912    Free PMC article.
Review.
Cerebral Gluconeogenesis and Diseases.
James Yip, Xiaokun Geng, Jiamei Shen, Yuchuan Ding.
Front Pharmacol, 2017 Jan 20; 7. PMID: 28101056    Free PMC article.
Review.
Is the Genetic Background of Co-Stimulatory CD28/CTLA-4 Pathway the Risk Factor for Prostate Cancer?
Lidia Karabon, K Tupikowski, +7 authors, I Frydecka.
Pathol Oncol Res, 2017 Jan 20; 23(4). PMID: 28101800
T-cell receptor-engineered T cells for cancer treatment: current status and future directions.
Yu Ping, Chaojun Liu, Yi Zhang.
Protein Cell, 2017 Jan 22; 9(3). PMID: 28108950    Free PMC article.
Highly Cited. Review.
Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.
Hui Zhang, Ryu Watanabe, +5 authors, Cornelia M Weyand.
Proc Natl Acad Sci U S A, 2017 Jan 25; 114(6). PMID: 28115719    Free PMC article.
Highly Cited.
PD-1/PD-L1 inhibitors in multiple myeloma: The present and the future.
T Jelinek, R Hajek.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123899    Free PMC article.
Review.
NLRX1 Regulates Effector and Metabolic Functions of CD4+ T Cells.
Andrew Leber, Raquel Hontecillas, +6 authors, Josep Bassaganya-Riera.
J Immunol, 2017 Feb 06; 198(6). PMID: 28159898    Free PMC article.
Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies.
A K S Salama, S J Moschos.
Ann Oncol, 2017 Feb 09; 28(1). PMID: 28177433    Free PMC article.
Review.
Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation.
Mai Fujiwara, Emily J Anstadt, Robert B Clark.
Front Immunol, 2017 Feb 12; 8. PMID: 28184224    Free PMC article.
Increased CTLA-4+ T cells may contribute to impaired T helper type 1 immune responses in patients with chronic obstructive pulmonary disease.
Dino B A Tan, Teck-Hui Teo, +5 authors, Yuben P Moodley.
Immunology, 2017 Feb 13; 151(2). PMID: 28190271    Free PMC article.
Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype.
Jie Wu, Liang Sun, +4 authors, Gang Chen.
J Neuroinflammation, 2017 Feb 16; 14(1). PMID: 28196545    Free PMC article.
Emerging role of checkpoint blockade therapy in lymphoma.
Natalie Galanina, Justin Kline, Michael R Bishop.
Ther Adv Hematol, 2017 Feb 17; 8(2). PMID: 28203344    Free PMC article.
Review.
Targeting the programmed death-1 pathway in lymphoid neoplasms.
Chi Young Ok, Ken H Young.
Cancer Treat Rev, 2017 Mar 01; 54. PMID: 28242522    Free PMC article.
Review.
Inflammatory cytokines compromise programmed cell death-1 (PD-1)-mediated T cell suppression in inflammatory arthritis through up-regulation of soluble PD-1.
D Bommarito, C Hall, L S Taams, V M Corrigall.
Clin Exp Immunol, 2017 Mar 01; 188(3). PMID: 28245522    Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors.
Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim.
Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545    Free PMC article.
Review.
Immunoregulatory functions of VISTA.
Elizabeth C Nowak, J Louise Lines, +7 authors, Randolph J Noelle.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258694    Free PMC article.
Highly Cited. Review.
Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.
Leslie S Kean, Laurence A Turka, Bruce R Blazar.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258702    Free PMC article.
Review.
In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network.
Kaitao Li, Xiaoxiao Cheng, +2 authors, Cheng Zhu.
J Biol Chem, 2017 Mar 09; 292(16). PMID: 28270509    Free PMC article.
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale.
Science, 2017 Mar 11; 355(6332). PMID: 28280247    Free PMC article.
Highly Cited.
The role of metabolic reprogramming in T cell fate and function.
Nikolaos Patsoukis, Kankana Bardhan, +4 authors, Vassiliki A Boussiotis.
Curr Trends Immunol, 2016 Jan 01; 17. PMID: 28356677    Free PMC article.
Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy.
Marianela Robainas, Rafael Otano, Stephen Bueno, Sihem Ait-Oudhia.
Onco Targets Ther, 2017 Apr 04; 10. PMID: 28367063    Free PMC article.
Review.
Cancer immunotherapies targeting the PD-1 signaling pathway.
Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo.
J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884    Free PMC article.
Highly Cited. Review.
Fine tuning of immunometabolism for the treatment of rheumatic diseases.
Jillian P Rhoads, Amy S Major, Jeffrey C Rathmell.
Nat Rev Rheumatol, 2017 Apr 07; 13(5). PMID: 28381829    Free PMC article.
Review.
Targeted Therapy in Head and Neck Cancer: An Update on Current Clinical Developments in Epidermal Growth Factor Receptor-Targeted Therapy and Immunotherapies.
Jonathan Moreira, Alexander Tobias, Michael P O'Brien, Mark Agulnik.
Drugs, 2017 Apr 07; 77(8). PMID: 28382569
Review.
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.
Levi J Rupp, Kathrin Schumann, +4 authors, Alexander Marson.
Sci Rep, 2017 Apr 09; 7(1). PMID: 28389661    Free PMC article.
Highly Cited.
Tuning cancer fate: the unremitting role of host immunity.
B Calì, B Molon, A Viola.
Open Biol, 2017 Apr 14; 7(4). PMID: 28404796    Free PMC article.
Review.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.
Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri.
Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974    Free PMC article.
Review.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
Melita Irving, Romain Vuillefroy de Silly, +2 authors, George Coukos.
Front Immunol, 2017 Apr 20; 8. PMID: 28421069    Free PMC article.
Review.
Enhanced antitumor effects by combining an IL-12/anti-DNA fusion protein with avelumab, an anti-PD-L1 antibody.
Jonathan K Fallon, Amanda J Vandeveer, Jeffrey Schlom, John W Greiner.
Oncotarget, 2017 Apr 21; 8(13). PMID: 28423552    Free PMC article.
Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses.
Nikolaos Patsoukis, Jessica D Weaver, +3 authors, Vassiliki A Boussiotis.
Front Immunol, 2017 Apr 27; 8. PMID: 28443090    Free PMC article.
Review.
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.
Seema Gupta, Amrita Roy, Bilikere S Dwarakanath.
Front Oncol, 2017 Apr 28; 7. PMID: 28447025    Free PMC article.
Highly Cited. Review.
Dysfunctional T cell metabolism in the tumor microenvironment.
Kathryn E Beckermann, Stephanie O Dudzinski, Jeffrey C Rathmell.
Cytokine Growth Factor Rev, 2017 May 01; 35. PMID: 28456467    Free PMC article.
Review.
Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries.
Ping-Chih Ho, Susan M Kaech.
Curr Opin Immunol, 2017 May 02; 46. PMID: 28458087    Free PMC article.
Review.
Dying to protect: cell death and the control of T-cell homeostasis.
Kun-Po Li, Sharmila Shanmuganad, +3 authors, David A Hildeman.
Immunol Rev, 2017 May 04; 277(1). PMID: 28462527    Free PMC article.
Review.
Metabolic Instruction of Immunity.
Michael D Buck, Ryan T Sowell, Susan M Kaech, Erika L Pearce.
Cell, 2017 May 06; 169(4). PMID: 28475890    Free PMC article.
Highly Cited. Review.
Checkpoint inhibitors in hematological malignancies.
Chi Young Ok, Ken H Young.
J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851    Free PMC article.
Highly Cited. Review.
PD-1 regulates KLRG1+ group 2 innate lymphoid cells.
Samuel Taylor, Yuefeng Huang, +12 authors, Shoba Amarnath.
J Exp Med, 2017 May 12; 214(6). PMID: 28490441    Free PMC article.
Highly Cited.
Mechanisms of Immune Tolerance in Leukemia and Lymphoma.
Emily K Curran, James Godfrey, Justin Kline.
Trends Immunol, 2017 May 18; 38(7). PMID: 28511816    Free PMC article.
Review.
Cancer Vaccines in Ovarian Cancer: How Can We Improve?
Silvia Martin Lluesma, Anita Wolfer, Alexandre Harari, Lana E Kandalaft.
Biomedicines, 2017 May 26; 4(2). PMID: 28536377    Free PMC article.
Review.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
Hwei-Fang Tsai, Ping-Ning Hsu.
J Biomed Sci, 2017 May 27; 24(1). PMID: 28545567    Free PMC article.
Review.
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
Peter J Siska, Kathryn E Beckermann, +15 authors, Jeffrey C Rathmell.
JCI Insight, 2017 Jun 15; 2(12). PMID: 28614802    Free PMC article.
Highly Cited.
PD-1 and cancer: molecular mechanisms and polymorphisms.
Arash Salmaninejad, Vahid Khoramshahi, +6 authors, Sayed Mostafa Hosseini.
Immunogenetics, 2017 Jun 24; 70(2). PMID: 28642997
Review.
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Andrew Gibson, Lee Faulkner, +8 authors, Dean J Naisbitt.
J Immunol, 2017 Jul 09; 199(4). PMID: 28687658    Free PMC article.
The role of PD-1 in regulation of macrophage apoptosis and its subversion by Leishmania donovani.
Shalini Roy, Purnima Gupta, +3 authors, Pijush K Das.
Clin Transl Immunology, 2017 Jul 12; 6(5). PMID: 28690843    Free PMC article.
Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers.
Y Liu, Y Cheng, +7 authors, C Ma.
Oncogene, 2017 Jul 12; 36(44). PMID: 28692048    Free PMC article.
Highly Cited.
Current Advances in Checkpoint Inhibitors: Lessons from Non-Central Nervous System Cancers and Potential for Glioblastoma.
Natasha Lakin, Robert Rulach, Stefan Nowicki, Kathreena M Kurian.
Front Oncol, 2017 Jul 22; 7. PMID: 28730140    Free PMC article.
Review.
Single versus combined immunoregulatory approach using PD-1 and CTLA-4 modulators in controlling sepsis.
Courtney P Rudick, David L Cornell, Devendra K Agrawal.
Expert Rev Clin Immunol, 2017 Jul 26; 13(9). PMID: 28742984    Free PMC article.
Review.
Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment.
Olumide Babajide Gbolahan, Amer M Zeidan, +4 authors, Heiko Konig.
Int J Mol Sci, 2017 Aug 02; 18(8). PMID: 28758974    Free PMC article.
Review.
Similarities in the Metabolic Reprogramming of Immune System and Endothelium.
Chu-Yik Tang, Claudio Mauro.
Front Immunol, 2017 Aug 09; 8. PMID: 28785263    Free PMC article.
Review.
Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma.
Russell Maxwell, Christopher M Jackson, Michael Lim.
Curr Treat Options Oncol, 2017 Aug 09; 18(8). PMID: 28785997
Review.
Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer.
Tao Shen, Liangjing Zhou, +4 authors, Liping Cao.
Sci Rep, 2017 Aug 12; 7(1). PMID: 28798308    Free PMC article.
Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition.
Li Yang, MingJing Shen, +5 authors, Soo Ok Lee.
Sci Rep, 2017 Aug 13; 7(1). PMID: 28801607    Free PMC article.
Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics.
Jonathan L Messerschmidt, Prianka Bhattacharya, Gerald L Messerschmidt.
Curr Oncol Rep, 2017 Aug 15; 19(10). PMID: 28803390
Review.
mTOR co-targeting strategies for head and neck cancer therapy.
Zhiyong Wang, Juan Callejas Valera, +2 authors, J Silvio Gutkind.
Cancer Metastasis Rev, 2017 Aug 20; 36(3). PMID: 28822012    Free PMC article.
Review.
Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells.
Rachel M Gibbons Johnson, Haidong Dong.
Front Immunol, 2017 Aug 30; 8. PMID: 28848559    Free PMC article.
Review.
The promise of immunotherapy in head and neck squamous cell carcinoma: combinatorial immunotherapy approaches.
Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri.
ESMO Open, 2017 Aug 30; 1(6). PMID: 28848660    Free PMC article.
Review.
Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels.
LiJun Xu, XiaoDong Chen, +7 authors, Soo Ok Lee.
Mol Oncol, 2017 Sep 03; 12(3). PMID: 28865178    Free PMC article.
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.
Ying Zhang, Raj Kurupati, +17 authors, Hildegund C J Ertl.
Cancer Cell, 2017 Sep 13; 32(3). PMID: 28898698    Free PMC article.
Highly Cited.
Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection.
Jeffrey E Teigler, Gennadiy Zelinskyy, +11 authors, Hendrik Streeck.
J Virol, 2017 Sep 15; 91(23). PMID: 28904197    Free PMC article.
A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab.
Petros Fessas, Hassal Lee, Shinji Ikemizu, Tobias Janowitz.
Semin Oncol, 2017 Sep 20; 44(2). PMID: 28923212    Free PMC article.
Review.
Inactivated Sendai virus particle upregulates cancer cell expression of intercellular adhesion molecule-1 and enhances natural killer cell sensitivity on cancer cells.
Simin Li, Tomoyuki Nishikawa, Yasufumi Kaneda.
Cancer Sci, 2017 Sep 26; 108(12). PMID: 28945328    Free PMC article.
The role of novel immunotherapies in non-Hodgkin lymphoma.
Allyson Pishko, Sunita D Nasta.
Transl Cancer Res, 2017 Sep 29; 6(1). PMID: 28955654    Free PMC article.
CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity.
Barbara Dillinger, Sarah Ahmadi-Erber, +7 authors, Alexander Michael Dohnal.
Front Immunol, 2017 Oct 06; 8. PMID: 28979262    Free PMC article.
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
Kaposi's Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes.
Kurtis M Host, Sarah R Jacobs, +5 authors, Blossom Damania.
mBio, 2017 Oct 12; 8(5). PMID: 29018115    Free PMC article.
Control of NK Cell Activation by Immune Checkpoint Molecules.
Asma Beldi-Ferchiou, Sophie Caillat-Zucman.
Int J Mol Sci, 2017 Oct 13; 18(10). PMID: 29023417    Free PMC article.
Review.
A Combination of Immune Checkpoint Inhibition with Metronomic Chemotherapy as a Way of Targeting Therapy-Resistant Cancer Cells.
Irina Kareva.
Int J Mol Sci, 2017 Oct 14; 18(10). PMID: 29027915    Free PMC article.
Review.
Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.
Grant M Fischer, Y N Vashisht Gopal, +3 authors, Michael A Davies.
Pigment Cell Melanoma Res, 2017 Oct 20; 31(1). PMID: 29049843    Free PMC article.
Review.
Effective antitumor peptide vaccines can induce severe autoimmune pathology.
Hussein Sultan, Jimena Trillo-Tinoco, Paulo Rodriguez, Esteban Celis.
Oncotarget, 2017 Oct 21; 8(41). PMID: 29050282    Free PMC article.
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Madhav Kishore, Kenneth C P Cheung, +17 authors, Federica M Marelli-Berg.
Immunity, 2017 Nov 23; 47(5). PMID: 29166588    Free PMC article.
Highly Cited.
Coxiella burnetii Lipopolysaccharide: What Do We Know?
Prasad Abnave, Xavier Muracciole, Eric Ghigo.
Int J Mol Sci, 2017 Nov 24; 18(12). PMID: 29168790    Free PMC article.
Review.
High-affinity human PD-L1 variants attenuate the suppression of T cell activation.
Zhaoduan Liang, Ye Tian, +5 authors, Yi Li.
Oncotarget, 2017 Nov 29; 8(51). PMID: 29179441    Free PMC article.
CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells.
Meagan R Rollins, Rachel M Gibbons Johnson.
J Immunol Res, 2017 Nov 29; 2017. PMID: 29181416    Free PMC article.
The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.
Mahnaz Janghorban, Ellen M Langer, +6 authors, Rosalie C Sears.
PLoS One, 2017 Dec 01; 12(11). PMID: 29190822    Free PMC article.
Advances in immunotherapeutic research for glioma therapy.
Jeremy Tetsuo Miyauchi, Stella E Tsirka.
J Neurol, 2017 Dec 07; 265(4). PMID: 29209782    Free PMC article.
Review.
Investigational PD-1 inhibitors in HL and NHL and biomarkers for predictors of response and outcome.
Andres Chang, Danielle Schlafer, Christopher R Flowers, Pamela B Allen.
Expert Opin Investig Drugs, 2017 Dec 13; 27(1). PMID: 29228840    Free PMC article.
Review.
Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients.
Oscar Arrieta, Edgar Montes-Servín, +6 authors, Lourdes Barrera.
Oncotarget, 2017 Dec 20; 8(60). PMID: 29254220    Free PMC article.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young.
Front Immunol, 2017 Dec 20; 8. PMID: 29255458    Free PMC article.
Highly Cited. Review.
The current status of immunobased therapies for metastatic renal-cell carcinoma.
Niranjan J Sathianathen, Suprita Krishna, +4 authors, Thomas S Griffith.
Immunotargets Ther, 2017 Dec 20; 6. PMID: 29255699    Free PMC article.
Review.
Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer.
Lina Liu, Yuhua Wang, +4 authors, Leaf Huang.
Mol Ther, 2017 Dec 21; 26(1). PMID: 29258739    Free PMC article.
PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer.
Henan Zhao, Duojiao Li, +4 authors, Xiaohong Shu.
Molecules, 2017 Dec 21; 22(12). PMID: 29261144    Free PMC article.
Review.
Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma.
Zhiying Shao, Andrew Z Wang, Daniel J George, Tian Zhang.
Asian J Urol, 2016 Oct 01; 3(4). PMID: 29264195    Free PMC article.
Review.
Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade.
Jie Bai, Zhitao Gao, +3 authors, Jing Nie.
Oncotarget, 2018 Jan 05; 8(66). PMID: 29299180    Free PMC article.
Review.
Immunotherapy for Non-small-cell Lung Cancer: Current Status and Future Obstacles.
Ju Hwan Cho.
Immune Netw, 2018 Jan 06; 17(6). PMID: 29302251    Free PMC article.
Review.
Inhibitors of the PD-1 Pathway in Tumor Therapy.
Martin W LaFleur, Yuki Muroyama, Charles G Drake, Arlene H Sharpe.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311378    Free PMC article.
Review.
Metabolic Barriers to T Cell Function in Tumors.
Ayaka Sugiura, Jeffrey C Rathmell.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311381    Free PMC article.
Highly Cited. Review.
Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies.
Gianfranco Mattia, Rossella Puglisi, +3 authors, Paola Matarrese.
Cell Death Dis, 2018 Jan 27; 9(2). PMID: 29371600    Free PMC article.
Highly Cited. Review.
PD-L1 checkpoint inhibition and anti-CTLA-4 whole tumor cell vaccination counter adaptive immune resistance: A mouse neuroblastoma model that mimics human disease.
Priya Srinivasan, Xiaofang Wu, +2 authors, Anthony D Sandler.
PLoS Med, 2018 Jan 30; 15(1). PMID: 29377881    Free PMC article.
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis.
Eleanor A Fallon, Bethany M Biron-Girard, +4 authors, Alfred Ayala.
J Leukoc Biol, 2018 Feb 03;. PMID: 29393983    Free PMC article.
Review.
Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies.
Danuta J Herzyk, Helen G Haggerty.
AAPS J, 2018 Feb 09; 20(2). PMID: 29417397
Review.
An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells.
Nicole A P Lieberman, Kole DeGolier, +6 authors, Courtney A Crane.
Front Immunol, 2018 Feb 20; 9. PMID: 29456538    Free PMC article.
Checks and Balances in Autoimmune Vasculitis.
Rebeca Hid Cadena, Wayel H Abdulahad, +4 authors, Elisabeth Brouwer.
Front Immunol, 2018 Mar 10; 9. PMID: 29520282    Free PMC article.
Review.
Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes.
Marco A Moro-García, Juan C Mayo, Rosa M Sainz, Rebeca Alonso-Arias.
Front Immunol, 2018 Mar 17; 9. PMID: 29545794    Free PMC article.
Review.
Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.
Marjolein W J Wentink, Yvonne M Mueller, +5 authors, Peter D Katsikis.
Front Immunol, 2018 Mar 23; 9. PMID: 29563914    Free PMC article.
Gut microbiome modulates efficacy of immune checkpoint inhibitors.
Ming Yi, Shengnan Yu, +5 authors, Kongming Wu.
J Hematol Oncol, 2018 Mar 28; 11(1). PMID: 29580257    Free PMC article.
Highly Cited. Review.
Overexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma.
Ziwen Zhu, Weiguo Dong.
Onco Targets Ther, 2018 Mar 30; 11. PMID: 29593422    Free PMC article.
Immunotherapy combination strategies (non-chemotherapy) in non-small cell lung cancer.
Sandrine Niyongere, Andreas Saltos, Jhanelle E Gray.
J Thorac Dis, 2018 Mar 30; 10(Suppl 3). PMID: 29593889    Free PMC article.
Review.
Treatment Options for Paediatric Anaplastic Large Cell Lymphoma (ALCL): Current Standard and beyond.
Nina Prokoph, Hugo Larose, +2 authors, Suzanne D Turner.
Cancers (Basel), 2018 Mar 31; 10(4). PMID: 29601554    Free PMC article.
Review.
Pembrolizumab and its role in relapsed/refractory classical Hodgkin's lymphoma: evidence to date and clinical utility.
Polina Shindiapina, Lapo Alinari.
Ther Adv Hematol, 2018 Apr 07; 9(4). PMID: 29623180    Free PMC article.
Review.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Should all patients with HL who relapse after ASCT be considered for allogeneic SCT? A consult, yes; a transplant, not necessarily.
Craig H Moskowitz.
Blood Adv, 2018 Apr 11; 2(7). PMID: 29636328    Free PMC article.
Systematic Review.
The research status of immune checkpoint blockade by anti-CTLA4 and anti-PD1/PD-l1 antibodies in tumor immunotherapy in China: A bibliometrics study.
Xiaoqin Zhao, Liangmei He, +3 authors, Zhiping Liu.
Medicine (Baltimore), 2018 Apr 12; 97(15). PMID: 29642147    Free PMC article.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations.
Judith A Seidel, Atsushi Otsuka, Kenji Kabashima.
Front Oncol, 2018 Apr 13; 8. PMID: 29644214    Free PMC article.
Highly Cited. Review.
Role of PD-1 during effector CD8 T cell differentiation.
Eunseon Ahn, Koichi Araki, +7 authors, Rafi Ahmed.
Proc Natl Acad Sci U S A, 2018 Apr 15; 115(18). PMID: 29654146    Free PMC article.
Highly Cited.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673    Free PMC article.
Review.
New Therapies in Head and Neck Cancer.
Rodell T Santuray, Daniel E Johnson, Jennifer R Grandis.
Trends Cancer, 2018 May 02; 4(5). PMID: 29709262    Free PMC article.
Review.
Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors.
Erika J Crosby, Junping Wei, +10 authors, Zachary C Hartman.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721371    Free PMC article.
Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer.
Timm Hoeres, Manfred Smetak, Dominik Pretscher, Martin Wilhelm.
Front Immunol, 2018 May 05; 9. PMID: 29725332    Free PMC article.
Highly Cited. Review.
Immunotherapies: Exploiting the Immune System for Cancer Treatment.
Jeffrey Koury, Mariana Lucero, +8 authors, Andrew Tran.
J Immunol Res, 2018 May 05; 2018. PMID: 29725606    Free PMC article.
Review.
Immune checkpoint receptors: homeostatic regulators of immunity.
Antonio Riva, Shilpa Chokshi.
Hepatol Int, 2018 May 10; 12(3). PMID: 29740793    Free PMC article.
Review.
Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC).
Young Kwang Chae, Ayush Arya, +4 authors, Francis Giles.
J Immunother Cancer, 2018 May 18; 6(1). PMID: 29769148    Free PMC article.
Highly Cited. Review.
Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade.
Winson S Ho, Herui Wang, +8 authors, Zhengping Zhuang.
Nat Commun, 2018 May 31; 9(1). PMID: 29844427    Free PMC article.
Immunotherapeutic interventions of Triple Negative Breast Cancer.
Zehuan Li, Yiran Qiu, +2 authors, Jin Wang.
J Transl Med, 2018 Jun 01; 16(1). PMID: 29848327    Free PMC article.
Review.
Immune checkpoint inhibitors and radiotherapy-concept and review of current literature.
Loka Thangamathesvaran, Roshni Shah, Rebeka Verma, Omar Mahmoud.
Ann Transl Med, 2018 Jun 05; 6(8). PMID: 29862244    Free PMC article.
Review.
Pushing the Limits of Cancer Therapy: The Nutrient Game.
Daniele Lettieri-Barbato, Katia Aquilano.
Front Oncol, 2018 Jun 06; 8. PMID: 29868472    Free PMC article.
Therapeutic Antibodies for Myeloid Neoplasms-Current Developments and Future Directions.
Christian M Schürch.
Front Oncol, 2018 Jun 06; 8. PMID: 29868474    Free PMC article.
Review.
Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.
Ee Lyn Lim, Fiorella M Cugliandolo, +3 authors, Klaus Okkenhaug.
JCI Insight, 2018 Jun 08; 3(11). PMID: 29875319    Free PMC article.
Association of Immune-Related Adverse Events with Clinical Benefit in Patients with Advanced Non-Small-Cell Lung Cancer Treated with Nivolumab.
Yukihiro Toi, Shunichi Sugawara, +14 authors, Yoshihiro Honda.
Oncologist, 2018 Jun 24; 23(11). PMID: 29934411    Free PMC article.
Highly Cited.
Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future.
Mark A Perazella, Anushree C Shirali.
J Am Soc Nephrol, 2018 Jul 01; 29(8). PMID: 29959196    Free PMC article.
Highly Cited. Review.
PD-L1, TIM-3, and CTLA-4 Blockade Fails To Promote Resistance to Secondary Infection with Virulent Strains of Toxoplasma gondii.
Samantha D Splitt, Scott P Souza, +4 authors, Kirk D C Jensen.
Infect Immun, 2018 Jul 04; 86(9). PMID: 29967089    Free PMC article.
Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers.
Muhammad Umair Mushtaq, Athanasios Papadas, +4 authors, Fotis Asimakopoulos.
J Immunother Cancer, 2018 Jul 05; 6(1). PMID: 29970158    Free PMC article.
Review.
Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity.
Jiu-Cheng Zhang, Wei-Dong Chen, +6 authors, Hua Zhu.
Acta Pharmacol Sin, 2018 Jul 12; 39(11). PMID: 29991709    Free PMC article.
Review.
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells.
Yunlong Zhao, Devin L Harrison, +3 authors, Enfu Hui.
Cell Rep, 2018 Jul 12; 24(2). PMID: 29996099    Free PMC article.
Myeloid Dendritic Cells Induce HIV Latency in Proliferating CD4+ T Cells.
Nitasha A Kumar, Renee M van der Sluis, +4 authors, Paul U Cameron.
J Immunol, 2018 Jul 22; 201(5). PMID: 30030324    Free PMC article.
MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers.
Yixin Yang, Christopher Alderman, +2 authors, Wei Wang.
Can J Gastroenterol Hepatol, 2018 Jul 27; 2018. PMID: 30046565    Free PMC article.
Review.
PD-1 Controls Follicular T Helper Cell Positioning and Function.
Jingwen Shi, Shiyue Hou, +3 authors, Hai Qi.
Immunity, 2018 Aug 05; 49(2). PMID: 30076099    Free PMC article.
Highly Cited.
Complex interplay between tumor microenvironment and cancer therapy.
Minhong Shen, Yibin Kang.
Front Med, 2018 Aug 12; 12(4). PMID: 30097962
Review.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance.
Young-Jun Park, Da-Sol Kuen, Yeonseok Chung.
Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516    Free PMC article.
Highly Cited. Review.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
Review.
Immune checkpoint inhibitors for hepatocellular carcinoma.
Christopher E Jensen, Arturo Loaiza-Bonilla, Paula A Bonilla-Reyes.
Hepat Oncol, 2016 Aug 01; 3(3). PMID: 30191042    Free PMC article.
Review.
New developments in immunotherapy for lymphoma.
Benjamin Heyman, Yiping Yang.
Cancer Biol Med, 2018 Sep 11; 15(3). PMID: 30197788    Free PMC article.
Cancer Immunotherapy in Diffuse Large B-Cell Lymphoma.
Jun Zhang, L Jeffrey Medeiros, Ken H Young.
Front Oncol, 2018 Sep 27; 8. PMID: 30250823    Free PMC article.
Review.
Checkpoint Inhibition in Myeloma: Opportunities and Challenges.
Federica Costa, Rituparna Das, +2 authors, Madhav V Dhodapkar.
Front Immunol, 2018 Oct 16; 9. PMID: 30319648    Free PMC article.
Review.
Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma.
Xingliang Guo, Hua Jiang, +9 authors, Zonghai Li.
Front Pharmacol, 2018 Oct 18; 9. PMID: 30327605    Free PMC article.
Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again.
Samantha L Bucktrout, Jeffrey A Bluestone, Fred Ramsdell.
Genome Med, 2018 Nov 01; 10(1). PMID: 30376867    Free PMC article.
Review.
The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production.
Felix Tolksdorf, Julita Mikulec, +6 authors, Linda Diehl.
Sci Rep, 2018 Nov 02; 8(1). PMID: 30382149    Free PMC article.
Immunology, Immunotherapy, and Translating Basic Science into the Clinic for Bladder Cancer.
Molly A Ingersoll, Xue Li, +3 authors, Rosalyn M Adam.
Bladder Cancer, 2018 Nov 13; 4(4). PMID: 30417054    Free PMC article.
Engineering CAR-T Cells for Improved Function Against Solid Tumors.
Michael A Morgan, Axel Schambach.
Front Immunol, 2018 Nov 14; 9. PMID: 30420856    Free PMC article.
Review.
T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses.
Alireza Saeidi, Keivan Zandi, +7 authors, Esaki Muthu Shankar.
Front Immunol, 2018 Nov 27; 9. PMID: 30473697    Free PMC article.
Highly Cited. Review.
Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma.
Tomas Jelinek, Bruno Paiva, Roman Hajek.
Front Immunol, 2018 Dec 07; 9. PMID: 30505301    Free PMC article.
Review.
BRAF and MEK inhibitors differentially affect nivolumab-induced T cell activation by modulating the TCR and AKT signaling pathways.
Peng Yue, Taylor Harper, +6 authors, Gerald M Feldman.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546949    Free PMC article.
Immunometabolism: A new target for improving cancer immunotherapy.
Chunqing Guo, Shixian Chen, +5 authors, Xiang-Yang Wang.
Adv Cancer Res, 2019 Jun 17; 143. PMID: 31202359    Free PMC article.
Review.
Programmed Death Ligand 1 (PD-L1) as a Predictive Biomarker for Pembrolizumab Therapy in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC).
Lorena Incorvaia, Daniele Fanale, +10 authors, Antonio Russo.
Adv Ther, 2019 Aug 23; 36(10). PMID: 31432460    Free PMC article.
Review.
Improved survival of chimeric antigen receptor-engineered T (CAR-T) and tumor-specific T cells caused by anti-programmed cell death protein 1 single-chain variable fragment-producing CAR-T cells.
Masao Nakajima, Yukimi Sakoda, +2 authors, Koji Tamada.
Cancer Sci, 2019 Aug 23; 110(10). PMID: 31432594    Free PMC article.
Bispecific T-Cell Redirection versus Chimeric Antigen Receptor (CAR)-T Cells as Approaches to Kill Cancer Cells.
William R Strohl, Michael Naso.
Antibodies (Basel), 2019 Sep 24; 8(3). PMID: 31544847    Free PMC article.
Review.
Molecular Modeling Studies on the Binding Mode of the PD-1/PD-L1 Complex Inhibitors.
Suliman Almahmoud, Haizhen A Zhong.
Int J Mol Sci, 2019 Sep 25; 20(18). PMID: 31546905    Free PMC article.
The splicing FK506-binding protein-51 isoform plays a role in glioblastoma resistance through programmed cell death ligand-1 expression regulation.
Paolo D'Arrigo, Marina Digregorio, +9 authors, Maria Fiammetta Romano.
Cell Death Discov, 2019 Oct 05; 5. PMID: 31583120    Free PMC article.
Immunotherapies and Future Combination Strategies for Head and Neck Squamous Cell Carcinoma.
Valerie Cristina, Ruth Gabriela Herrera-Gómez, +2 authors, Marco Siano.
Int J Mol Sci, 2019 Nov 02; 20(21). PMID: 31671550    Free PMC article.
Review.
BATF Potentially Mediates Negative Regulation of PD-1/PD-Ls Pathway on T Cell Functions in Mycobacterium tuberculosis Infection.
Qianqian Liu, Qinfang Ou, +6 authors, Zheng W Chen.
Front Immunol, 2019 Nov 05; 10. PMID: 31681314    Free PMC article.
Recent advances and application of PD-1 blockade in sarcoma.
Wenli Zuo, Lingdi Zhao.
Onco Targets Ther, 2019 Nov 07; 12. PMID: 31692518    Free PMC article.
Secondary resistance to immunotherapy associated with β-catenin pathway activation or PTEN loss in metastatic melanoma.
Jonathan A Trujillo, Jason J Luke, +5 authors, Thomas F Gajewski.
J Immunother Cancer, 2019 Nov 11; 7(1). PMID: 31703593    Free PMC article.
The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma.
Peng Liao, Haofan Wang, +2 authors, Xin-Hua Liang.
Front Immunol, 2019 Nov 12; 10. PMID: 31708918    Free PMC article.
Review.
Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer.
Sehui Kim, Ji-Young Jang, +10 authors, Yoon Kyung Jeon.
J Exp Clin Cancer Res, 2019 Nov 14; 38(1). PMID: 31718692    Free PMC article.
Immune checkpoint inhibitor-associated gastrointestinal and hepatic adverse events and their management.
Uday N Shivaji, Louisa Jeffery, +5 authors, Marietta Iacucci.
Therap Adv Gastroenterol, 2019 Nov 15; 12. PMID: 31723355    Free PMC article.
Review.
Check Point Inhibitors and Their Role in Immunosuppression in Sepsis.
Michelle E Wakeley, Chyna C Gray, +2 authors, Alfred Ayala.
Crit Care Clin, 2019 Nov 18; 36(1). PMID: 31733683    Free PMC article.
Review.
Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis.
Nicolaos Jay Palaskas, Jacob David Garcia, +5 authors, Thomas Glen Graeber.
Cell Discov, 2019 Dec 05; 5. PMID: 31798961    Free PMC article.
Observational Molecular Case-Control Study of Genetic Polymorphisms 1 in Programmed Cell Death Protein-1 in Patients with Oral Lichen Planus
Janan Ghapanchi, Hamid Ghaderi, +6 authors, Ahmad Hasan Kalantari.
Asian Pac J Cancer Prev, 2019 Feb 26; 20(2). PMID: 30803202    Free PMC article.
Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors.
Sophia C Weinmann, David S Pisetsky.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816080    Free PMC article.
Review.
From Super-Enhancer Non-coding RNA to Immune Checkpoint: Frameworks to Functions.
Manqing Wu, Jun Shen.
Front Oncol, 2019 Dec 12; 9. PMID: 31824865    Free PMC article.
Review.
The influence of microenvironment on tumor immunotherapy.
Jieying Zhang, Zhaopeng Shi, +2 authors, Jun Mi.
FEBS J, 2019 Aug 01; 286(21). PMID: 31365790    Free PMC article.
Review.
A systematic analysis of immune genes and overall survival in cancer patients.
Qian Wang, Pan Li, Weidong Wu.
BMC Cancer, 2019 Dec 18; 19(1). PMID: 31842801    Free PMC article.
Immune Response Against Head and Neck Cancer: Biological Mechanisms and Implication on Therapy.
Francesco Perri, Franco Ionna, +5 authors, Francesco Caponigro.
Transl Oncol, 2019 Dec 24; 13(2). PMID: 31869751    Free PMC article.
Review.
CTLA-4 correlates with immune and clinical characteristics of glioma.
Fangkun Liu, Jing Huang, +3 authors, Zhixiong Liu.
Cancer Cell Int, 2020 Jan 09; 20. PMID: 31911758    Free PMC article.
Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity.
Hao Shi, Hongbo Chi.
Front Immunol, 2020 Jan 11; 10. PMID: 31921097    Free PMC article.
Review.
Basis of PD1/PD-L1 Therapies.
Barbara Seliger.
J Clin Med, 2019 Dec 11; 8(12). PMID: 31817953    Free PMC article.
Review.
Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment.
Yangjing Zhao, Qixiang Shao, Guangyong Peng.
Cell Mol Immunol, 2019 Dec 20; 17(1). PMID: 31853000    Free PMC article.
Review.
Prevalence of programmed death-1 ligand-1 (PD-L1) and infiltrating lymphocytes in human gastric carcinogenesis.
Zhonghua Liu, Yufang Wang, +3 authors, Tao Wang.
Int J Clin Exp Pathol, 2017 Dec 01; 10(12). PMID: 31966537    Free PMC article.
Immunotherapy Is Changing First-Line Treatment of Metastatic Renal-Cell Carcinoma.
Matthew K Labriola, Kristen A Batich, +5 authors, Tian Zhang.
Clin Genitourin Cancer, 2019 Mar 13; 17(3). PMID: 30858035    Free PMC article.
Review.
The Potential Role of Inhibitory Receptors in the Treatment of Psoriasis.
Neha Shah, Sabina Sandigursky, Adam Mor.
Bull Hosp Jt Dis (2013), 2017 Sep 14; 75(3). PMID: 28902599    Free PMC article.
Review.
T-cell exhaustion in HIV infection.
Craig Fenwick, Victor Joo, +4 authors, Giuseppe Pantaleo.
Immunol Rev, 2019 Dec 29; 292(1). PMID: 31883174    Free PMC article.
Review.
Paradox-driven adventures in the development of cancer immunology and immunotherapy.
Whitney Barham, Joanina K Gicobi, +2 authors, Haidong Dong.
Genes Dis, 2020 Feb 12; 6(3). PMID: 32042862    Free PMC article.
Review.
Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms.
Mikayel Mkrtichyan, Yana G Najjar, +5 authors, Samir N Khleif.
Eur J Immunol, 2011 Jun 29; 41(10). PMID: 21710477    Free PMC article.
B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets.
Mikayel Mkrtichyan, Yana G Najjar, +5 authors, Samir N Khleif.
J Immunol, 2012 Jul 28; 189(5). PMID: 22837483    Free PMC article.
Recent advances in the clinical development of immune checkpoint blockade therapy.
Atefeh Ghahremanloo, Arash Soltani, Seyed Mohamad Sadegh Modaresi, Seyed Isaac Hashemy.
Cell Oncol (Dordr), 2019 Jun 16; 42(5). PMID: 31201647
Review.
Therapeutic Monoclonal Antibodies and Antibody Products: Current Practices and Development in Multiple Myeloma.
Francesca Bonello, Roberto Mina, Mario Boccadoro, Francesca Gay.
Cancers (Basel), 2019 Dec 22; 12(1). PMID: 31861548    Free PMC article.
Review.
Structure and Optimization of Checkpoint Inhibitors.
Sarah L Picardo, Jeffrey Doi, Aaron R Hansen.
Cancers (Basel), 2019 Dec 28; 12(1). PMID: 31877721    Free PMC article.
Review.
NK Cell-Based Immune Checkpoint Inhibition.
Muhammad Khan, Sumbal Arooj, Hua Wang.
Front Immunol, 2020 Mar 03; 11. PMID: 32117298    Free PMC article.
Review.
Resistance to Checkpoint Inhibition in Cancer Immunotherapy.
Luisa Barrueto, Francheska Caminero, +3 authors, Rahul R Deshmukh.
Transl Oncol, 2020 Mar 03; 13(3). PMID: 32114384    Free PMC article.
Review.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han.
J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595    Free PMC article.
Highly Cited. Review.
PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity.
Jacqueline Moebius, Rajan Guha, +8 authors, Peter D Crompton.
Infect Immun, 2020 Jan 08; 88(3). PMID: 31907195    Free PMC article.
Translating In Vitro T Cell Metabolic Findings to In Vivo Tumor Models of Nutrient Competition.
Christopher Ecker, James L Riley.
Cell Metab, 2018 Aug 09; 28(2). PMID: 30089240    Free PMC article.
Review.
High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin, Ekaterina Esaulova, +16 authors, Maxim N Artyomov.
Cell, 2018 Oct 23; 175(4). PMID: 30343900    Free PMC article.
Highly Cited.
Targeting PP2A in cancer: Combination therapies.
Sahar Mazhar, Sarah E Taylor, Jaya Sangodkar, Goutham Narla.
Biochim Biophys Acta Mol Cell Res, 2018 Nov 08; 1866(1). PMID: 30401535    Free PMC article.
Review.
Analysis of expression of the PD-1/PD-L1 immune checkpoint system and its prognostic impact in gastroenteropancreatic neuroendocrine tumors.
Miguel Sampedro-Núñez, Ana Serrano-Somavilla, +12 authors, Mónica Marazuela.
Sci Rep, 2018 Dec 14; 8(1). PMID: 30546030    Free PMC article.
Human CD8+HLA-DR+ Regulatory T Cells, Similarly to Classical CD4+Foxp3+ Cells, Suppress Immune Responses via PD-1/PD-L1 Axis.
Andres Machicote, Santiago Belén, +2 authors, Leonardo Fainboim.
Front Immunol, 2018 Dec 18; 9. PMID: 30555473    Free PMC article.
Profiling Preexisting Antibodies in Patients Treated With Anti-PD-1 Therapy for Advanced Non-Small Cell Lung Cancer.
Yukihiro Toi, Shunichi Sugawara, +15 authors, Yoshihiro Honda.
JAMA Oncol, 2018 Dec 28; 5(3). PMID: 30589930    Free PMC article.
Highly Cited.
Reining in the CD8+ T cell: Respiratory virus infection and PD-1-mediated T-cell impairment.
Meredith C Rogers, John V Williams.
PLoS Pathog, 2019 Jan 04; 15(1). PMID: 30605483    Free PMC article.
Review.
The Role of Co-stimulatory/Co-inhibitory Signals in Graft-vs.-Host Disease.
Sandeep Kumar, Nicholas D Leigh, Xuefang Cao.
Front Immunol, 2019 Jan 11; 9. PMID: 30627129    Free PMC article.
Review.
Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells.
Christine E Nelson, Lauren J Mills, +6 authors, Vaiva Vezys.
Proc Natl Acad Sci U S A, 2019 Jan 27; 116(7). PMID: 30679280    Free PMC article.
IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection.
Carleigh A O'Brien, Samantha J Batista, Katherine M Still, Tajie H Harris.
J Immunol, 2019 Feb 06; 202(6). PMID: 30718297    Free PMC article.
Advances in immunotherapy delivery from implantable and injectable biomaterials.
David G Leach, Simon Young, Jeffrey D Hartgerink.
Acta Biomater, 2019 Feb 17; 88. PMID: 30771535    Free PMC article.
Review.
Cancer Metabolism Drives a Stromal Regenerative Response.
Simon Schwörer, Santosha A Vardhana, Craig B Thompson.
Cell Metab, 2019 Feb 19; 29(3). PMID: 30773467    Free PMC article.
Review.
Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus.
Shannon M Kahan, Allan J Zajac.
Viruses, 2019 Feb 20; 11(2). PMID: 30781904    Free PMC article.
Review.
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Spencer C Wei, Roshan Sharma, +8 authors, James P Allison.
Immunity, 2019 Mar 31; 50(4). PMID: 30926234    Free PMC article.
CD8+ T cell exhaustion.
Makoto Kurachi.
Semin Immunopathol, 2019 Apr 17; 41(3). PMID: 30989321
Review.
Bispecific CD3-HAC carried by E1A-engineered mesenchymal stromal cells against metastatic breast cancer by blocking PD-L1 and activating T cells.
Yuanyuan Yang, Xiaolong Zhang, +11 authors, Dongsheng Xiong.
J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023384    Free PMC article.
Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy.
Ee Lyn Lim, Klaus Okkenhaug.
Immunology, 2019 May 21; 157(3). PMID: 31107985    Free PMC article.
Review.
The Role of Checkpoint Inhibitors in Glioblastoma.
Kunal Desai, Anne Hubben, Manmeet Ahluwalia.
Target Oncol, 2019 Jul 11; 14(4). PMID: 31290002
Review.
T Cell Reprogramming Against Cancer.
Samuel G Katz, Peter M Rabinovich.
Methods Mol Biol, 2019 Nov 30; 2097. PMID: 31776916    Free PMC article.
Review.
The Role of Immune Checkpoint Blockade in Uveal Melanoma.
Anja Wessely, Theresa Steeb, +5 authors, Markus Vincent Heppt.
Int J Mol Sci, 2020 Feb 06; 21(3). PMID: 32013269    Free PMC article.
Review.
High PD-L1 expression in the tumour cells did not correlate with poor prognosis of patients suffering for oral squamous cells carcinoma: A meta-analysis of the literature.
Giuseppe Troiano, Vito C A Caponio, +5 authors, Lorenzo Lo Muzio.
Cell Prolif, 2018 Nov 18; 52(2). PMID: 30443950    Free PMC article.
Systematic Review.
Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer.
Prachya Kongtawelert, Benjawan Wudtiwai, +2 authors, Thanyaluck Phitak.
Molecules, 2020 Jan 16; 25(2). PMID: 31936263    Free PMC article.
Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection.
Amit Kumar Singh, Sukeshani Salwe, +7 authors, Vainav Patel.
Front Immunol, 2020 Mar 21; 11. PMID: 32194543    Free PMC article.
Prospects for combining immune checkpoint blockade with PARP inhibition.
Anping Li, Ming Yi, +3 authors, Kongming Wu.
J Hematol Oncol, 2019 Sep 16; 12(1). PMID: 31521196    Free PMC article.
Review.
Role of Macrophages in Pregnancy and Related Complications.
Manoj K Jena, Neha Nayak, Kang Chen, Nihar R Nayak.
Arch Immunol Ther Exp (Warsz), 2019 Jul 10; 67(5). PMID: 31286151    Free PMC article.
Review.
T cell Metabolism in Lupus.
Milena Vukelic, Michihito Kono, George C Tsokos.
Immunometabolism, 2020 Apr 08; 2(2). PMID: 32257420    Free PMC article.
PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.
Reina Mizuno, Daisuke Sugiura, +4 authors, Taku Okazaki.
Front Immunol, 2019 Apr 20; 10. PMID: 31001256    Free PMC article.
The Role of PD-1 in Acute and Chronic Infection.
Jil M Jubel, Zachary R Barbati, +2 authors, Frank A Schildberg.
Front Immunol, 2020 Apr 09; 11. PMID: 32265932    Free PMC article.
Review.
Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells.
Rhiane Moody, Kirsty Wilson, Anthony Jaworowski, Magdalena Plebanski.
Cancers (Basel), 2020 Mar 19; 12(3). PMID: 32183059    Free PMC article.
Review.
Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity.
Tabea Haug, Michael Aigner, +6 authors, Simon Völkl.
Front Immunol, 2019 May 21; 10. PMID: 31105702    Free PMC article.
Expression of programmed cell death-1 and its ligand B7 homolog 1 in peripheral blood lymphocytes from patients with peripartum cardiomyopathy.
Guozhi Xia, Xiaopu Zheng, +3 authors, Junkui Wang.
Clin Cardiol, 2016 Dec 28; 40(5). PMID: 28026044    Free PMC article.
Immune Cytolytic Activity Is Associated With Genetic and Clinical Properties of Glioma.
Zhi-Liang Wang, Zheng Wang, +4 authors, Tao Jiang.
Front Immunol, 2019 Aug 21; 10. PMID: 31428092    Free PMC article.
Immune-Related Adverse Events: Pneumonitis.
Linda Zhong, Mehmet Altan, Vickie R Shannon, Ajay Sheshadri.
Adv Exp Med Biol, 2020 Apr 18; 1244. PMID: 32301020    Free PMC article.
Review.
Prognostic Significance of Potential Immune Checkpoint Member HHLA2 in Human Tumors: A Comprehensive Analysis.
Ben Wang, Zhujie Ran, Mengmeng Liu, Yunsheng Ou.
Front Immunol, 2019 Aug 06; 10. PMID: 31379814    Free PMC article.
Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation.
Jennifer L Hope, Christopher J Stairiker, +2 authors, Linda M Bradley.
Front Immunol, 2019 Aug 06; 10. PMID: 31379821    Free PMC article.
Review.
The Role of the Lymphocyte Functional Crosstalk and Regulation in the Context of Checkpoint Inhibitor Treatment-Review.
Barbara Seliger.
Front Immunol, 2019 Sep 27; 10. PMID: 31555274    Free PMC article.
Review.
Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.
Laura Strauss, Mohamed A A Mahmoud, +8 authors, Vassiliki A Boussiotis.
Sci Immunol, 2020 Jan 05; 5(43). PMID: 31901074    Free PMC article.
Clinical Pharmacokinetic and Pharmacodynamic Considerations in the (Modern) Treatment of Melanoma.
Hannah Yejin Kim, Parth J Upadhyay, +3 authors, Alan V Boddy.
Clin Pharmacokinet, 2019 Mar 15; 58(8). PMID: 30868471
Review.
Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives.
Stefania Raimondo, Marzia Pucci, Riccardo Alessandro, Simona Fontana.
Int J Mol Sci, 2020 Apr 01; 21(7). PMID: 32225076    Free PMC article.
Review.
T cell costimulation, checkpoint inhibitors and anti-tumor therapy.
Dipankar Nandi, Sanmoy Pathak, +6 authors, Vijayamahantesh.
J Biosci, 2020 Apr 30; 45. PMID: 32345776
Review.
Solid Tumors Challenges and New Insights of CAR T Cell Engineering.
Safa Tahmasebi, Reza Elahi, Abdolreza Esmaeilzadeh.
Stem Cell Rev Rep, 2019 Jun 05; 15(5). PMID: 31161552
Review.
Immune-based therapies for hepatocellular carcinoma.
David J Pinato, Nadia Guerra, +8 authors, Lorenza Rimassa.
Oncogene, 2020 Mar 12; 39(18). PMID: 32157213    Free PMC article.
Review.
The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy.
Aaron R Lim, W Kimryn Rathmell, Jeffrey C Rathmell.
Elife, 2020 May 06; 9. PMID: 32367803    Free PMC article.
Review.
Expression of the checkpoint receptors LAG-3, TIM-3 and VISTA in peripheral T cell lymphomas.
Carlos A Murga-Zamalloa, Noah A Brown, Ryan A Wilcox.
J Clin Pathol, 2019 Nov 02; 73(4). PMID: 31672704    Free PMC article.
Prognostic and Clinicopathological Role of PD-L1 in Endometrial Cancer: A Meta-Analysis.
Ling Lu, Yonghong Li, +3 authors, Mingqiang Wang.
Front Oncol, 2020 May 20; 10. PMID: 32426281    Free PMC article.
Systematic Review.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
Review.
Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway.
Craig Fenwick, Juan-Luis Loredo-Varela, +11 authors, Giuseppe Pantaleo.
J Exp Med, 2019 May 28; 216(7). PMID: 31123083    Free PMC article.
Manipulating Gut Microbiota Composition to Enhance the Therapeutic Effect of Cancer Immunotherapy.
Ming Yi, Dechao Jiao, +3 authors, Kongming Wu.
Integr Cancer Ther, 2019 Sep 14; 18. PMID: 31517538    Free PMC article.
Review.
CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.
Yang Liu, Yuting Gao, Huiqin Hao, Tiezheng Hou.
FEBS Open Bio, 2020 Apr 24; 10(6). PMID: 32324337    Free PMC article.
Facing SARS-CoV-2 outbreak in immunotherapy era.
Fabrizio Citarella, Marco Russano, +4 authors, Daniele Santini.
Future Oncol, 2020 May 30; 16(20). PMID: 32468851    Free PMC article.
Review.
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.
Rodolfo Daniel Cervantes-Villagrana, Damaris Albores-García, Alberto Rafael Cervantes-Villagrana, Sara Judit García-Acevez.
Signal Transduct Target Ther, 2020 Jun 20; 5(1). PMID: 32555170    Free PMC article.
Review.
Noncoding RNAs: the shot callers in tumor immune escape.
Lei Liu, Qin Wang, +6 authors, Shouping Xu.
Signal Transduct Target Ther, 2020 Jun 21; 5(1). PMID: 32561709    Free PMC article.
Review.
Manipulation of Metabolic Pathways and Its Consequences for Anti-Tumor Immunity: A Clinical Perspective.
Huang-Yu Yang, Chao-Yi Wu, Jonathan D Powell, Kun-Lin Lu.
Int J Mol Sci, 2020 Jun 10; 21(11). PMID: 32512898    Free PMC article.
Review.
T Cells and Regulated Cell Death: Kill or Be Killed.
Johan Spetz, Adam G Presser, Kristopher A Sarosiek.
Int Rev Cell Mol Biol, 2019 Jan 13; 342. PMID: 30635093    Free PMC article.
Review.
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy.
Jackie E Bader, Kelsey Voss, Jeffrey C Rathmell.
Mol Cell, 2020 Jun 20; 78(6). PMID: 32559423    Free PMC article.
Review.
[PD-1 expression on the surface of peripheral blood CD4+T cell and its association with the prognosis of patients with peripheral T/NK cell lymphoma].
J F Bai, M X Zuo, +4 authors, W Zhang.
Zhonghua Xue Ye Xue Za Zhi, 2016 Nov 02; 37(10). PMID: 27801329    Free PMC article.
Current Strategies and Novel Therapeutic Approaches for Metastatic Urothelial Carcinoma.
Veronica Mollica, Alessandro Rizzo, +9 authors, Francesco Massari.
Cancers (Basel), 2020 Jun 06; 12(6). PMID: 32498352    Free PMC article.
Review.
Feasibility of sleeve lobectomy after neo-adjuvant chemo-immunotherapy in non-small cell lung cancer.
Yulong Chen, Lianmin Zhang, +5 authors, Jian You.
Transl Lung Cancer Res, 2020 Jul 18; 9(3). PMID: 32676337    Free PMC article.
The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection.
Kristen E Pauken, Jernej Godec, +13 authors, Arlene H Sharpe.
Cell Rep, 2020 Jul 02; 31(13). PMID: 32610128    Free PMC article.
Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.
Diwakar Davar, Hassane M Zarour.
Methods Mol Biol, 2019 Sep 11; 2055. PMID: 31502146    Free PMC article.
Review.
The Role of Immunomodulatory Receptors in the Pathogenesis of HIV Infection: A Therapeutic Opportunity for HIV Cure?
Hui Chen, Maha Moussa, Marta Catalfamo.
Front Immunol, 2020 Jul 28; 11. PMID: 32714317    Free PMC article.
Review.
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.
Selena Vigano, Sara Bobisse, +2 authors, Alexandre Harari.
Front Immunol, 2020 Jul 28; 11. PMID: 32714330    Free PMC article.
Review.
MicroRNA-138-5p Suppresses Non-small Cell Lung Cancer Cells by Targeting PD-L1/PD-1 to Regulate Tumor Microenvironment.
Nannan Song, Peng Li, +9 authors, Wei Lin.
Front Cell Dev Biol, 2020 Aug 06; 8. PMID: 32754587    Free PMC article.
The Impact of Malaria Parasites on Dendritic Cell-T Cell Interaction.
Rowland S Osii, Thomas D Otto, +2 authors, James M Brewer.
Front Immunol, 2020 Aug 15; 11. PMID: 32793231    Free PMC article.
Review.
Phase II Study of the PD-1 Inhibitor Pembrolizumab for the Treatment of Relapsed or Refractory Mature T-cell Lymphoma.
Stefan K Barta, Jasmine Zain, +14 authors, Yasuhiro Oki.
Clin Lymphoma Myeloma Leuk, 2019 Apr 29; 19(6). PMID: 31029646    Free PMC article.
Immune checkpoint signaling and cancer immunotherapy.
Xing He, Chenqi Xu.
Cell Res, 2020 May 30; 30(8). PMID: 32467592    Free PMC article.
Review.
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.
Santosha A Vardhana, Madeline A Hwee, +10 authors, Craig B Thompson.
Nat Immunol, 2020 Jul 15; 21(9). PMID: 32661364    Free PMC article.
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
Lukas Amon, Lukas Hatscher, +2 authors, Christian H K Lehmann.
Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488    Free PMC article.
Review.
Anti-PD-1 Therapy-Associated Type 1 Diabetes in a Pediatric Patient With Relapsed Classical Hodgkin Lymphoma.
Raynald A Samoa, Hayley S Lee, Sung H Kil, Bart O Roep.
Diabetes Care, 2020 Jul 04; 43(9). PMID: 32616607    Free PMC article.
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response.
Lucas Leite Cunha, Sandro Felix Perazzio, +2 authors, Leonardo Vidal Riella.
Front Immunol, 2020 Aug 28; 11. PMID: 32849623    Free PMC article.
Review.
Biological Landscape of Triple Negative Breast Cancers Expressing CTLA-4.
María G C Navarrete-Bernal, Mayte G Cervantes-Badillo, +14 authors, Leticia Rocha-Zavaleta.
Front Oncol, 2020 Aug 28; 10. PMID: 32850353    Free PMC article.
Evolving insights into the mechanisms of toxicity associated with immune checkpoint inhibitor therapy.
Brendan L Mangan, Renee K McAlister, +4 authors, Elizabeth J Phillips.
Br J Clin Pharmacol, 2020 Jun 17; 86(9). PMID: 32543711    Free PMC article.
Review.
Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma.
Dominic Maggio, Winson S Ho, +8 authors, Zhengping Zhuang.
J Neurooncol, 2020 Apr 29; 148(2). PMID: 32342332    Free PMC article.
Integrative Approaches to Cancer Immunotherapy.
Gregory L Szeto, Stacey D Finley.
Trends Cancer, 2019 Jul 18; 5(7). PMID: 31311655    Free PMC article.
Review.
Innovative CAR-T Cell Therapy for Solid Tumor; Current Duel between CAR-T Spear and Tumor Shield.
Yuna Jo, Laraib Amir Ali, +2 authors, Changwan Hong.
Cancers (Basel), 2020 Aug 01; 12(8). PMID: 32731404    Free PMC article.
Review.
Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages.
Karolina I Smolag, Christine M Mueni, +6 authors, Anna M Blom.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923173    Free PMC article.
Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma.
Shaoping Shen, Ling Chen, +8 authors, Tianyi Liu.
Cancer Biol Med, 2020 Sep 19; 17(3). PMID: 32944390    Free PMC article.
Review.
Immunotherapy in urothelial cancer, part 1: T-cell checkpoint inhibition in advanced or metastatic disease.
Steven S Yu, Tanya B Dorff, +3 authors, David I Quinn.
Clin Adv Hematol Oncol, 2017 Jul 28; 15(6). PMID: 28749907    Free PMC article.
Review.
Sepsis-Induced Immunosuppression in Neonates.
Julie E Hibbert, Andrew Currie, Tobias Strunk.
Front Pediatr, 2018 Dec 18; 6. PMID: 30555806    Free PMC article.
Review.
Critical factors in chimeric antigen receptor-modified T-cell (CAR-T) therapy for solid tumors.
Lingli Yan, Bainan Liu.
Onco Targets Ther, 2019 Jan 15; 12. PMID: 30636882    Free PMC article.
Review.
PD-L2 expression is correlated with the molecular and clinical features of glioma, and acts as an unfavorable prognostic factor.
Zhi-Liang Wang, Guan-Zhang Li, +4 authors, Tao Jiang.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713802    Free PMC article.
PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression.
Francesca R Mariotti, Stefania Petrini, +9 authors, Lorenzo Moretta.
Oncoimmunology, 2019 Feb 07; 8(3). PMID: 30723590    Free PMC article.
Highly Cited.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma.
Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns.
Front Oncol, 2019 Mar 12; 8. PMID: 30854331    Free PMC article.
Review.
Risk and incidence of fatal adverse events associated with immune checkpoint inhibitors: a systematic review and meta-analysis.
Yi Jiang, Ning Zhang, +2 authors, Helong Zhang.
Ther Clin Risk Manag, 2019 Mar 13; 15. PMID: 30858709    Free PMC article.
Immune mechanisms of idiosyncratic drug-induced liver injury.
Alastair Mak, Jack Uetrecht.
J Clin Transl Res, 2017 Feb 12; 3(1). PMID: 30873473    Free PMC article.
Review.
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade.
Mingxia Zhao, Wenjie Guo, +11 authors, Yang Sun.
Acta Pharm Sin B, 2019 Apr 12; 9(2). PMID: 30972278    Free PMC article.
Highly Cited.
Immune reaction by cytoreductive prostatectomy.
Geun Taek Lee, Arnav Srivastava, Young Suk Kwon, Isaac Yi Kim.
Am J Clin Exp Urol, 2019 May 30; 7(2). PMID: 31139701    Free PMC article.
Review.
Differential Kinase Activation in Peripheral Blood Mononuclear Cells from Non-Small-Cell Lung Cancer Patients Treated with Nivolumab.
Gaëlle Noé, Audrey Bellesoeur, +9 authors, Michel Vidal.
Cancers (Basel), 2019 Jun 05; 11(6). PMID: 31159331    Free PMC article.
Rational Combination of Parvovirus H1 With CTLA-4 and PD-1 Checkpoint Inhibitors Dampens the Tumor Induced Immune Silencing.
Katrin Goepfert, Christiane Dinsart, +2 authors, Markus Moehler.
Front Oncol, 2019 Jun 14; 9. PMID: 31192129    Free PMC article.
T lymphocytes against solid malignancies: winning ways to defeat tumours.
Ignazio Caruana, Luca Simula, Franco Locatelli, Silvia Campello.
Cell Stress, 2019 Jun 22; 2(8). PMID: 31225487    Free PMC article.
Review.
Monoclonal Antibody: A New Treatment Strategy against Multiple Myeloma.
Shih-Feng Cho, Liang Lin, +4 authors, Yu-Tzu Tai.
Antibodies (Basel), 2017 Nov 14; 6(4). PMID: 31548533    Free PMC article.
Review.
Immune checkpoint inhibitors in esophageal squamous cell carcinoma: progress and opportunities.
Ruidi Jiao, Hui Luo, Wenbo Xu, Hong Ge.
Onco Targets Ther, 2019 Sep 26; 12. PMID: 31551657    Free PMC article.
Immunotherapy in urothelial cancer, part 2: adjuvant, neoadjuvant, and adjunctive treatment.
Steven S Yu, Leslie K Ballas, +3 authors, David I Quinn.
Clin Adv Hematol Oncol, 2017 Jul 28; 15(7). PMID: 28749918    Free PMC article.
Review.
Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection.
Ioana Sandu, Dario Cerletti, Manfred Claassen, Annette Oxenius.
Nat Commun, 2020 Sep 10; 11(1). PMID: 32901001    Free PMC article.
Revisiting the PD-1 pathway.
Nikolaos Patsoukis, Qi Wang, Laura Strauss, Vassiliki A Boussiotis.
Sci Adv, 2020 Sep 20; 6(38). PMID: 32948597    Free PMC article.
Review.
Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy.
Leilei Ai, Jian Chen, +4 authors, Xiaochun Yang.
Drug Des Devel Ther, 2020 Sep 29; 14. PMID: 32982171    Free PMC article.
Review.
Rewiring Mitochondrial Metabolism for CD8+ T Cell Memory Formation and Effective Cancer Immunotherapy.
Wenhui Li, Lianjun Zhang.
Front Immunol, 2020 Sep 29; 11. PMID: 32983095    Free PMC article.
Review.
Phase II study of atezolizumab in combination with bevacizumab in patients with advanced cervical cancer.
Claire F Friedman, Alexandra Snyder Charen, +12 authors, Dmitriy Zamarin.
J Immunother Cancer, 2020 Oct 03; 8(2). PMID: 33004542    Free PMC article.
Hepatocellular Carcinoma-The Influence of Immunoanatomy and the Role of Immunotherapy.
Keyur Patel, Ryan Lamm, +2 authors, Ashesh P Shah.
Int J Mol Sci, 2020 Sep 19; 21(18). PMID: 32942580    Free PMC article.
Review.
The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer.
Xin-Wei Qiao, Jian Jiang, +4 authors, Ya-Ling Tang.
Front Immunol, 2020 Oct 20; 11. PMID: 33072064    Free PMC article.
Review.
Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy.
Simone Nüssing, Joseph A Trapani, Ian A Parish.
Front Immunol, 2020 Oct 20; 11. PMID: 33072137    Free PMC article.
Review.
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
Catherine L Tan, Juhi R Kuchroo, +15 authors, Arlene H Sharpe.
J Exp Med, 2020 Oct 13; 218(1). PMID: 33045061    Free PMC article.
Heat Shock Proteins and PD-1/PD-L1 as Potential Therapeutic Targets in Myeloproliferative Neoplasms.
Steven De Almeida, Mathilde Regimbeau, +3 authors, François Hermetet.
Cancers (Basel), 2020 Sep 17; 12(9). PMID: 32932806    Free PMC article.
Review.
iRGD Peptide as a Tumor-Penetrating Enhancer for Tumor-Targeted Drug Delivery.
Sujin Kang, Sooyeun Lee, Soyeun Park.
Polymers (Basel), 2020 Aug 28; 12(9). PMID: 32847045    Free PMC article.
Review.
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells.
Lei Tao, Muhammad Asad Farooq, +9 authors, Wenzheng Jiang.
Cancers (Basel), 2020 Sep 17; 12(9). PMID: 32933182    Free PMC article.
Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy.
Jiaqi Li, Jie Qing Eu, +4 authors, Andrea L A Wong.
Molecules, 2020 Oct 24; 25(20). PMID: 33092283    Free PMC article.
Review.
Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy.
Italia Falcone, Fabiana Conciatori, +4 authors, Michele Milella.
Cancers (Basel), 2020 Oct 11; 12(10). PMID: 33036192    Free PMC article.
Review.
Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook.
Patrick C Gedeon, Cosette D Champion, +6 authors, John H Sampson.
Expert Rev Clin Pharmacol, 2020 Aug 31; 13(10). PMID: 32862726    Free PMC article.
Systematic Review.
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy.
Weimin Wang, Weiping Zou.
Mol Cell, 2020 Oct 01; 80(3). PMID: 32997964    Free PMC article.
Review.
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies.
Kaijian Zhou, Shu Guo, +2 authors, Guoxin Liang.
Front Cell Dev Biol, 2020 Nov 13; 8. PMID: 33178688    Free PMC article.
Review.
Immune Checkpoints and CAR-T Cells: The Pioneers in Future Cancer Therapies?
Negar Hosseinkhani, Afshin Derakhshani, +9 authors, Behzad Baradaran.
Int J Mol Sci, 2020 Nov 11; 21(21). PMID: 33167514    Free PMC article.
Review.
Liposome-Based Drug Delivery Systems in Cancer Immunotherapy.
Zili Gu, Candido G Da Silva, +2 authors, Luis J Cruz.
Pharmaceutics, 2020 Nov 08; 12(11). PMID: 33158166    Free PMC article.
Review.
Breast Cancer Heterogeneity and Response to Novel Therapeutics.
Mariona Baliu-Piqué, Atanasio Pandiella, Alberto Ocana.
Cancers (Basel), 2020 Nov 11; 12(11). PMID: 33167363    Free PMC article.
Review.
Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer.
Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri.
Cancers (Basel), 2020 Nov 19; 12(11). PMID: 33203092    Free PMC article.
Review.
Recovery from experimental autoimmune uveitis promotes induction of antiuveitic inducible Tregs.
Darren J Lee, Andrew W Taylor.
J Leukoc Biol, 2015 Apr 17; 97(6). PMID: 25877928    Free PMC article.
The Therapeutic Potential of T Cell Metabolism.
A Zarrinpar, S J Bensinger.
Am J Transplant, 2016 Dec 09; 17(7). PMID: 27931083    Free PMC article.
Review.
mTORC1 and mTORC2 as regulators of cell metabolism in immunity.
Monika Linke, Stephanie Deborah Fritsch, +2 authors, Thomas Weichhart.
FEBS Lett, 2017 Jun 11; 591(19). PMID: 28600802    Free PMC article.
Highly Cited. Review.
Immunotherapy for metastatic prostate cancer: immuno-cold or the tip of the iceberg?
Andrew L Laccetti, Sumit K Subudhi.
Curr Opin Urol, 2017 Aug 22; 27(6). PMID: 28825923    Free PMC article.
Review.
Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts.
Brenda Raud, Peter J McGuire, +2 authors, Luciana Berod.
Immunol Rev, 2018 Apr 18; 283(1). PMID: 29664569    Free PMC article.
Review.
Rational combination of cancer immunotherapy in melanoma.
Mario Mandalà, Piotr Rutkowski.
Virchows Arch, 2018 Dec 16; 474(4). PMID: 30552520
Review.
Changes in plasma EBV-DNA and immune status in patients with nasopharyngeal carcinoma after treatment with intensity-modulated radiotherapy.
Qi Chen, Wei Hu, +4 authors, Hongsheng Lu.
Diagn Pathol, 2019 Mar 16; 14(1). PMID: 30871579    Free PMC article.
Understanding Immune Evasion and Therapeutic Targeting Associated with PD-1/PD-L1 Pathway in Diffuse Large B-cell Lymphoma.
Moo-Kon Song, Byeong-Bae Park, Jieun Uhm.
Int J Mol Sci, 2019 Mar 20; 20(6). PMID: 30884772    Free PMC article.
Review.
The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer.
Jiajing Cai, Qi Qi, +4 authors, Rong Xia.
J Cancer Res Clin Oncol, 2019 Apr 10; 145(6). PMID: 30963235
Review.
Clinical development of targeted and immune based anti-cancer therapies.
N A Seebacher, A E Stacy, G M Porter, A M Merlot.
J Exp Clin Cancer Res, 2019 Apr 13; 38(1). PMID: 30975211    Free PMC article.
Review.
Sustained partial remission of a metastatic NEN using off-label immunotherapy with pembrolizumab.
Anna Kathrin Stüven, Bertram Wiedenmann.
Oncotarget, 2019 May 31; 10(35). PMID: 31143376    Free PMC article.
Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells.
Grace Mallett, Arian Laurence, Shoba Amarnath.
Int J Mol Sci, 2019 Jun 20; 20(11). PMID: 31212601    Free PMC article.
Review.
Anti-PD-1 and anti-PD-L1 drugs treatment-related adverse events for patients with cancer: Protocol for an overview of systematic reviews with meta-analyses.
Jing Li, Ming Liu, +4 authors, JunHai Jia.
Medicine (Baltimore), 2019 Jul 07; 98(27). PMID: 31277179    Free PMC article.
Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis.
Liling Wen, Huanzi Lu, +8 authors, Zhi Wang.
J Exp Clin Cancer Res, 2019 Jul 12; 38(1). PMID: 31291983    Free PMC article.
Streptococcal Pyrogenic Exotoxin A-Stimulated Monocytes Mediate Regulatory T-Cell Accumulation through PD-L1 and Kynurenine.
Katharina Giesbrecht, Sandra Förmer, +2 authors, Dagmar Hildebrand.
Int J Mol Sci, 2019 Aug 16; 20(16). PMID: 31412561    Free PMC article.
Tumor Metabolism as a Regulator of Tumor-Host Interactions in the B-Cell Lymphoma Microenvironment-Fueling Progression and Novel Brakes for Therapy.
Anna C Beielstein, Christian P Pallasch.
Int J Mol Sci, 2019 Aug 29; 20(17). PMID: 31454887    Free PMC article.
Review.
TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials.
Khalil Choucair, Susan Morand, +3 authors, John Nemunaitis.
Cancer Gene Ther, 2020 Apr 29; 27(12). PMID: 32341410
Review.
Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
Javier Arranz-Nicolás, Miguel Martin-Salgado, +6 authors, Isabel Merida.
J Immunother Cancer, 2020 Nov 29; 8(2). PMID: 33246984    Free PMC article.
Overcoming Immune Evasion in Melanoma.
Kevinn Eddy, Suzie Chen.
Int J Mol Sci, 2020 Dec 02; 21(23). PMID: 33256089    Free PMC article.
Review.
Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer.
Sabah Nisar, Ajaz A Bhat, +8 authors, Mohammad Haris.
J Transl Med, 2020 Dec 11; 18(1). PMID: 33298096    Free PMC article.
Review.
The importance of exosomal PDL1 in tumour immune evasion.
Dhouha Daassi, Kathleen M Mahoney, Gordon J Freeman.
Nat Rev Immunol, 2020 Jan 23; 20(4). PMID: 31965064
Review.
Precursor exhausted T cells: key to successful immunotherapy?
Axel Kallies, Dietmar Zehn, Daniel T Utzschneider.
Nat Rev Immunol, 2019 Oct 09; 20(2). PMID: 31591533
Review.
Competitive glucose metabolism as a target to boost bladder cancer immunotherapy.
Julieta Afonso, Lúcio L Santos, Adhemar Longatto-Filho, Fátima Baltazar.
Nat Rev Urol, 2020 Jan 19; 17(2). PMID: 31953517
Review.
Relationship between Programmed Cell Death Protein Ligand 1 Expression and Immune-related Adverse Events in Non-small-cell Lung Cancer Patients Treated with Pembrolizumab.
Jun Sugisaka, Yukihiro Toi, +16 authors, Shunichi Sugawara.
JMA J, 2020 Dec 17; 3(1). PMID: 33324776    Free PMC article.
T Cell Dysfunction in Cancer.
Daniela S Thommen, Ton N Schumacher.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634943    Free PMC article.
Highly Cited. Review.
Characterizing heterogeneity of non-small cell lung tumour microenvironment to identify signature prognostic genes.
Kai Mi, Fuhui Chen, +8 authors, Desi Shang.
J Cell Mol Med, 2020 Nov 14; 24(24). PMID: 33184998    Free PMC article.
Immunometabolism and HIV-1 pathogenesis: food for thought.
Asier Sáez-Cirión, Irini Sereti.
Nat Rev Immunol, 2020 Aug 09; 21(1). PMID: 32764670
Review.
Roles of mitochondria in the hallmarks of metastasis.
Adam D Scheid, Thomas C Beadnell, Danny R Welch.
Br J Cancer, 2020 Nov 05; 124(1). PMID: 33144695    Free PMC article.
Review.
Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling.
Peng Chen, Ramanaiah Mamillapalli, Shutaro Habata, Hugh S Taylor.
Mol Cell Biochem, 2021 Jan 12; 476(4). PMID: 33428059
Counteracting CAR T cell dysfunction.
Mansour Poorebrahim, Jeroen Melief, +3 authors, Rolf Kiessling.
Oncogene, 2020 Nov 11; 40(2). PMID: 33168929    Free PMC article.
Review.
How we treat endocrine complications of immune checkpoint inhibitors.
S A Paschou, K Stefanaki, +5 authors, M-A Dimopoulos.
ESMO Open, 2021 Jan 06; 6(1). PMID: 33399077    Free PMC article.
Review.
PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression.
Federica Costa, Valentina Marchica, +2 authors, Nicola Giuliani.
Cancers (Basel), 2021 Jan 10; 13(2). PMID: 33418913    Free PMC article.
Review.
Immune-Checkpoint Inhibitors in B-Cell Lymphoma.
Marc Armengol, Juliana Carvalho Santos, +3 authors, Gaël Roué.
Cancers (Basel), 2021 Jan 13; 13(2). PMID: 33430146    Free PMC article.
Review.
Hematopoietic versus Solid Cancers and T Cell Dysfunction: Looking for Similarities and Distinctions.
Chiara Montironi, Cristina Muñoz-Pinedo, Eric Eldering.
Cancers (Basel), 2021 Jan 21; 13(2). PMID: 33466674    Free PMC article.
Review.
Therapy of lymphoma by immune checkpoint inhibitors: the role of T cells, NK cells and cytokine-induced tumor senescence.
Fatima Ahmetlic, Josia Fauser, +8 authors, Ralph Mocikat.
J Immunother Cancer, 2021 Jan 15; 9(1). PMID: 33441389    Free PMC article.
Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy.
Qin Qiu, Yuqi Lin, +8 authors, Lianxiang Luo.
Front Immunol, 2021 Jan 26; 11. PMID: 33488618    Free PMC article.
Review.
Development of CAR-T Cell Persistence in Adoptive Immunotherapy of Solid Tumors.
Jiaqiao Fan, Jugal Kishore Das, +2 authors, Jianxun Song.
Front Oncol, 2021 Jan 26; 10. PMID: 33489881    Free PMC article.
Idiopathic CD4 T Cell Lymphocytopenia: A Case of Overexpression of PD-1/PDL-1 and CTLA-4.
Gaurav Kumar, Heidy Schmid-Antomarchi, +2 authors, Pierre-Marie Roger.
Infect Dis Rep, 2021 Jan 17; 13(1). PMID: 33450836    Free PMC article.
SARS-CoV-2 infection: The role of PD-1/PD-L1 and CTLA-4 axis.
Parisa Shiri Aghbash, Narges Eslami, +2 authors, Hossein Bannazadeh Baghi.
Life Sci, 2021 Jan 29; 270. PMID: 33508291    Free PMC article.
Review.
Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity.
Noëlla Lopes, Bruno Silva-Santos.
Eur J Immunol, 2020 Nov 15; 51(1). PMID: 33188652    Free PMC article.
Review.
The Updated Status and Future Direction of Immunotherapy Targeting B7-H1/PD-1 in Osteosarcoma.
Meng-Ke Fan, Li-Li Qi, Qi Zhang, Ling Wang.
Cancer Manag Res, 2021 Feb 05; 13. PMID: 33536783    Free PMC article.
Review.
Human microbiome and prostate cancer development: current insights into the prevention and treatment.
Solmaz Ohadian Moghadam, Seyed Ali Momeni.
Front Med, 2020 Jul 02; 15(1). PMID: 32607819
Review.
Metabolism of immune cells in cancer.
Robert D Leone, Jonathan D Powell.
Nat Rev Cancer, 2020 Jul 08; 20(9). PMID: 32632251    Free PMC article.
Review.
Development of an Oncogenic Driver Alteration Associated Immune-Related Prognostic Model for Stage I-II Lung Adenocarcinoma.
Jian-Zhao Xu, Chen Gong, Zheng-Fu Xie, Hua Zhao.
Front Oncol, 2021 Feb 16; 10. PMID: 33585210    Free PMC article.
Genetic engineering of T cells for immunotherapy.
Gavin I Ellis, Neil C Sheppard, James L Riley.
Nat Rev Genet, 2021 Feb 20; 22(7). PMID: 33603158    Free PMC article.
Review.
Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression.
Margaret A McBride, Tazeen K Patil, +3 authors, Naeem K Patil.
Front Immunol, 2021 Feb 23; 11. PMID: 33613563    Free PMC article.
Review.
Immune Checkpoint Inhibitors: Cardiotoxicity in Pre-clinical Models and Clinical Studies.
Shirley Xu, Umesh C Sharma, Cheyanna Tuttle, Saraswati Pokharel.
Front Cardiovasc Med, 2021 Feb 23; 8. PMID: 33614750    Free PMC article.
Review.
Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment.
Mariam Mroweh, Gaël Roth, +3 authors, Zuzana Macek Jílková.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33670268    Free PMC article.
Review.
Abdominal immune-related adverse events: detection on ultrasonography, CT, MRI and 18F-Fluorodeoxyglucose positron emission tomography.
Mark A Anderson, Vikram Kurra, +3 authors, Susanna I Lee.
Br J Radiol, 2020 Oct 29; 94(1118). PMID: 33112648    Free PMC article.
Review.
T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies.
Lu Tang, Yinqiang Zhang, Yu Hu, Heng Mei.
Biomed Res Int, 2021 Mar 18; 2021. PMID: 33728333    Free PMC article.
Review.
[Developments in Immunotherapy for Advanced Non-small Cell Lung Cancer].
Haoyang Li, Jinghui Wang.
Zhongguo Fei Ai Za Zhi, 2021 Jan 29; 24(2). PMID: 33508897    Free PMC article.
Review.
Insulin-mediated immune dysfunction in the development of preeclampsia.
Gustav van Niekerk, Claudia Christowitz, Anna-Mart Engelbrecht.
J Mol Med (Berl), 2021 Mar 27; 99(7). PMID: 33768298
Review.
Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment.
Guangna Liu, Wei Rui, Xueqiang Zhao, Xin Lin.
Cell Mol Immunol, 2021 Apr 01; 18(5). PMID: 33785843    Free PMC article.
Review.
Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy.
Guillermo O Rangel Rivera, Hannah M Knochelmann, +5 authors, Chrystal M Paulos.
Front Immunol, 2021 Apr 06; 12. PMID: 33815400    Free PMC article.
Review.
Advanced Nanotechnology for Enhancing Immune Checkpoint Blockade Therapy.
Chiara Cremolini, Emanuela Vitale, Raffaella Rastaldo, Claudia Giachino.
Nanomaterials (Basel), 2021 Apr 04; 11(3). PMID: 33800368    Free PMC article.
Review.
Immune System Alterations in Multiple Myeloma: Molecular Mechanisms and Therapeutic Strategies to Reverse Immunosuppression.
Andrea Díaz-Tejedor, Mauro Lorenzo-Mohamed, +4 authors, Teresa Paíno.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33802806    Free PMC article.
Review.
Impaired Butyrate Induced Regulation of T Cell Surface Expression of CTLA-4 in Patients with Ulcerative Colitis.
Maria K Magnusson, Alexander Vidal, +4 authors, Lena Öhman.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33802979    Free PMC article.
LFA-1 cluster formation in T-cells depends on L-plastin phosphorylation regulated by P90RSK and PP2A.
Guido H Wabnitz, Sibylle Honus, +3 authors, Yvonne Samstag.
Cell Mol Life Sci, 2021 Jan 16; 78(7). PMID: 33449151
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison.
Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470    Free PMC article.
Single-cell transcriptomics reveal the intratumoral landscape of infiltrated T-cell subpopulations in oral squamous cell carcinoma.
Jingtao Chen, Jiefeng Yang, +7 authors, Ming Song.
Mol Oncol, 2021 Jan 30; 15(4). PMID: 33513276    Free PMC article.
Immuno-oncology: a narrative review of gastrointestinal and hepatic toxicities.
Stergios Boussios, Matin Sheriff, +7 authors, Nicholas Pavlidis.
Ann Transl Med, 2021 Apr 13; 9(5). PMID: 33842644    Free PMC article.
Review.
An unexpected role for p53 in regulating cancer cell-intrinsic PD-1 by acetylation.
Zhijie Cao, Ning Kon, +9 authors, Donglai Wang.
Sci Adv, 2021 Apr 02; 7(14). PMID: 33789902    Free PMC article.
Novel approaches to enhance the specificity and safety of engineered T cells.
Victor D Fedorov, Michel Sadelain, Christopher C Kloss.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667964    Free PMC article.
Immunometabolism: From basic mechanisms to translation.
Liza Makowski, Mehdi Chaib, Jeffrey C Rathmell.
Immunol Rev, 2020 Apr 23; 295(1). PMID: 32320073    Free PMC article.
Review.
Paraneoplastic Neurological Syndromes and Beyond Emerging With the Introduction of Immune Checkpoint Inhibitor Cancer Immunotherapy.
Cristina Valencia-Sanchez, Anastasia Zekeridou.
Front Neurol, 2021 Apr 27; 12. PMID: 33897597    Free PMC article.
Review.
Human splenic myeloid derived suppressor cells: Phenotypic and clustering analysis.
Kathryn E Cole, Quan P Ly, +5 authors, James E Talmadge.
Cell Immunol, 2021 Mar 15; 363. PMID: 33714729    Free PMC article.
Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/β-catenin (cyclin D1) axis.
Su-Jin Yang, Dan-Dan Wang, +11 authors, Jin-Hai Tang.
Cell Death Dis, 2021 Apr 30; 12(5). PMID: 33911067    Free PMC article.
The role of dendritic cells for therapy of B-cell lymphoma with immune checkpoint inhibitors.
Anne Scheuerpflug, Fatima Ahmetlić, +3 authors, Ralph Mocikat.
Cancer Immunol Immunother, 2020 Nov 04; 70(5). PMID: 33141285    Free PMC article.
Prevalence, therapy and tumour response in patients with rheumatic immune-related adverse events following immune checkpoint inhibitor therapy: a single-centre analysis.
Sophia H Verspohl, Tobias Holderried, +2 authors, Valentin S Schäfer.
Ther Adv Musculoskelet Dis, 2021 Apr 30; 13. PMID: 33912248    Free PMC article.
Metabolic barriers to cancer immunotherapy.
Kristin DePeaux, Greg M Delgoffe.
Nat Rev Immunol, 2021 May 01; 21(12). PMID: 33927375    Free PMC article.
Review.
Checkpoint Inhibitor-Induced Colitis-A Clinical Overview of Incidence, Prognostic Implications and Extension of Current Treatment Options.
Carmen Portenkirchner, Peter Kienle, Karoline Horisberger.
Pharmaceuticals (Basel), 2021 May 01; 14(4). PMID: 33923423    Free PMC article.
Review.
PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition.
Kaitao Li, Zhou Yuan, +4 authors, Cheng Zhu.
Nat Commun, 2021 May 14; 12(1). PMID: 33980853    Free PMC article.
Biological drug and drug delivery-mediated immunotherapy.
Qingqing Xiao, Xiaotong Li, +4 authors, Wei He.
Acta Pharm Sin B, 2021 May 18; 11(4). PMID: 33996408    Free PMC article.
Review.
Metabolism of Immune Cells in the Tumor Microenvironment.
Jin G Jung, Anne Le.
Adv Exp Med Biol, 2021 May 21; 1311. PMID: 34014543
How Can We Engineer CAR T Cells to Overcome Resistance?
Maya Glover, Stephanie Avraamides, John Maher.
Biologics, 2021 May 28; 15. PMID: 34040345    Free PMC article.
Review.
Methods to Study Posttranslational Modification Patterns in Cytotoxic T-Cells and Cancer.
Annamaria Deleonardis, Massimo Papale.
Methods Mol Biol, 2021 May 31; 2325. PMID: 34053056
Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development.
Seyed Hossein Kiaie, Mohammad Javad Sanaei, +5 authors, Behzad Baradaran.
Acta Pharm Sin B, 2021 Jun 08; 11(5). PMID: 34094821    Free PMC article.
Review.
Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions.
Anna S Tocheva, Michael Peled, +9 authors, Adam Mor.
J Biol Chem, 2020 Oct 21; 295(52). PMID: 33077516    Free PMC article.
Identification of Precise Therapeutic Targets and Characteristic Prognostic Genes Based on Immune Gene Characteristics in Uveal Melanoma.
Zhenxi Zhang, Jingyu Su, Li Li, Wenjing Du.
Front Cell Dev Biol, 2021 Jun 15; 9. PMID: 34124047    Free PMC article.
PI3K inhibitors are finally coming of age.
Bart Vanhaesebroeck, Matthew W D Perry, +2 authors, Klaus Okkenhaug.
Nat Rev Drug Discov, 2021 Jun 16; 20(10). PMID: 34127844
Review.
Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies.
Yara Abdou, Manu Pandey, +3 authors, Marc S Ernstoff.
Br J Clin Pharmacol, 2020 Apr 24; 86(9). PMID: 32323342    Free PMC article.
Review.
Optical Control of CD8+ T Cell Metabolism and Effector Functions.
Andrea M Amitrano, Brandon J Berry, +4 authors, Minsoo Kim.
Front Immunol, 2021 Jun 22; 12. PMID: 34149701    Free PMC article.
Reversing Post-Infectious Epigenetic-Mediated Immune Suppression.
Abhimanyu, Carlos O Ontiveros, +5 authors, Andrew R DiNardo.
Front Immunol, 2021 Jun 25; 12. PMID: 34163486    Free PMC article.
Review.
Metabolic Interplay between the Immune System and Melanoma Cells: Therapeutic Implications.
Alice Indini, Francesco Grossi, +2 authors, Valentina Audrito.
Biomedicines, 2021 Jun 03; 9(6). PMID: 34073463    Free PMC article.
Review.
Icaritin inhibits PD-L1 expression by Targeting Protein IκB Kinase α.
Dongliang Mo, Hai Zhu, +12 authors, Kun Meng.
Eur J Immunol, 2020 Dec 24; 51(4). PMID: 33354776    Free PMC article.
Two Complementarity Immunotherapeutics in Non-Small-Cell Lung Cancer Patients-Mechanism of Action and Future Concepts.
Kamila Wojas-Krawczyk, Paweł Krawczyk, Michał Gil, Maciej Strzemski.
Cancers (Basel), 2021 Jul 03; 13(11). PMID: 34200219    Free PMC article.
Review.
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment.
Qin Xie, Jian Ding, Yi Chen.
Acta Pharm Sin B, 2021 Jul 06; 11(6). PMID: 34221857    Free PMC article.
Review.
The therapeutic implications of immunosuppressive tumor aerobic glycolysis.
Bradley I Reinfeld, W Kimryn Rathmell, Tae Kon Kim, Jeffrey C Rathmell.
Cell Mol Immunol, 2021 Jul 10; 19(1). PMID: 34239083    Free PMC article.
Review.
A phase I study of IMC-001, a PD-L1 blocker, in patients with metastatic or locally advanced solid tumors.
Bhumsuk Keam, Chan-Young Ock, +12 authors, Young Suk Park.
Invest New Drugs, 2021 Jul 17; 39(6). PMID: 34268711
Immune checkpoint blockade impairs immunosuppressive mechanisms of regulatory T cells in B-cell lymphoma.
Vera Bauer, Fatima Ahmetlić, +3 authors, Ralph Mocikat.
Transl Oncol, 2021 Jul 07; 14(9). PMID: 34229208    Free PMC article.
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy.
Bonnie L Russell, Selisha A Sooklal, +2 authors, Monde Ntwasa.
Front Oncol, 2021 Jul 17; 11. PMID: 34268109    Free PMC article.
Review.
The Complex Integration of T-cell Metabolism and Immunotherapy.
Matthew Z Madden, Jeffrey C Rathmell.
Cancer Discov, 2021 Apr 03; 11(7). PMID: 33795235    Free PMC article.
Review.
ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas.
Houshi Xu, Anke Zhang, +5 authors, Meiqing Lou.
Cancer Immunol Immunother, 2021 Jul 28; 71(3). PMID: 34313821
New insights into the important roles of tumor cell-intrinsic PD-1.
Hongmei Zheng, Yue Ning, +3 authors, Songqing Fan.
Int J Biol Sci, 2021 Jul 31; 17(10). PMID: 34326692    Free PMC article.
Review.
Distinct difference in tumor-infiltrating immune cells between Wilms' tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies.
Chisato Yokota, Jun Nakata, +15 authors, Haruhiko Kishima.
Neurooncol Adv, 2021 Aug 07; 3(1). PMID: 34355173    Free PMC article.
Immunometabolism Modulation in Therapy.
Ezequiel Monferrer, Sabina Sanegre, +8 authors, Tomás Álvaro Naranjo.
Biomedicines, 2021 Aug 07; 9(7). PMID: 34356862    Free PMC article.
Review.
Molecular Mechanisms of Resistance to Immune Checkpoint Inhibitors in Melanoma Treatment: An Update.
Sonja Vukadin, Farah Khaznadar, +2 authors, Martina Smolic.
Biomedicines, 2021 Aug 07; 9(7). PMID: 34356899    Free PMC article.
Review.
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer.
Macus Hao-Ran Bao, Carmen Chak-Lui Wong.
Cells, 2021 Aug 08; 10(7). PMID: 34359884    Free PMC article.
Review.
TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer.
Zhouhong Ge, Maikel P Peppelenbosch, Dave Sprengers, Jaap Kwekkeboom.
Front Immunol, 2021 Aug 10; 12. PMID: 34367161    Free PMC article.
Review.
PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective.
HaiXia Li, Chao Zheng, +3 authors, Tao Jin.
Front Cell Neurosci, 2021 Aug 13; 15. PMID: 34381337    Free PMC article.
Review.
Chimeric non-antigen receptors in T cell-based cancer therapy.
Jitao Guo, Andrew Kent, Eduardo Davila.
J Immunother Cancer, 2021 Aug 05; 9(8). PMID: 34344725    Free PMC article.
Review.
COVID-19, what could sepsis, severe acute pancreatitis, gender differences, and aging teach us?
Claudio G Gallo, Sirio Fiorino, +12 authors, Marco Zancanaro.
Cytokine, 2021 Aug 20; 148. PMID: 34411989    Free PMC article.
Review.
sCD28, sCD80, sCTLA-4, and sBTLA Are Promising Markers in Diagnostic and Therapeutic Approaches for Aseptic Loosening and Periprosthetic Joint Infection.
Jil M Jubel, Thomas M Randau, +6 authors, Frank A Schildberg.
Front Immunol, 2021 Aug 24; 12. PMID: 34421900    Free PMC article.
Tumor Secretome to Adoptive Cellular Immunotherapy: Reduce Me Before I Make You My Partner.
Mikel Etxebeste-Mitxeltorena, Inés Del Rincón-Loza, Beatriz Martín-Antonio.
Front Immunol, 2021 Aug 28; 12. PMID: 34447383    Free PMC article.
Review.
Role of the PD-1/PD-L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions.
Yan Mi, Jinming Han, Jie Zhu, Tao Jin.
Mol Neurobiol, 2021 Sep 05; 58(12). PMID: 34480337    Free PMC article.
Review.
Curcumin as an Adjuvant to Cancer Immunotherapy.
Silpita Paul, Gaurisankar Sa.
Front Oncol, 2021 Sep 07; 11. PMID: 34485117    Free PMC article.
Review.
Immune Checkpoint Inhibitors in Urothelial Bladder Cancer: State of the Art and Future Perspectives.
Giandomenico Roviello, Martina Catalano, +7 authors, Gabriella Nesi.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503220    Free PMC article.
Review.
Susceptibility of CTLA-4 -1661A/G polymorphism towards severity of rheumatic heart disease.
Ankit Bansal, Sana Tasnim, +5 authors, M A Qadar Pasha.
Indian Heart J, 2021 Sep 04; 73(4). PMID: 34474769    Free PMC article.
Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and -γ.
Sanjay Chandrasekaran, Christopher Ronald Funk, +3 authors, Edmund K Waller.
Front Immunol, 2021 Sep 14; 12. PMID: 34512641    Free PMC article.
Review.
Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
Wenjing Qian, Mingfang Zhao, Ruoyu Wang, Heming Li.
J Hematol Oncol, 2021 Sep 17; 14(1). PMID: 34526102    Free PMC article.
Review.
Immune Checkpoint Inhibitor in First-Line Treatment of Metastatic Renal Cell Carcinoma: A Review of Current Evidence and Future Directions.
Iris Tung, Arvind Sahu.
Front Oncol, 2021 Sep 17; 11. PMID: 34527581    Free PMC article.
Review.
Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer.
Yong-Bo Kang, Yue Cai.
World J Gastroenterol, 2021 Sep 21; 27(32). PMID: 34539138    Free PMC article.
Review.
Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma.
Yujia Xia, Zachary J Brown, Hai Huang, Allan Tsung.
Cancer Med, 2021 Aug 15; 10(18). PMID: 34390203    Free PMC article.
Review.
Immune Checkpoint Inhibitors in People Living with HIV/AIDS: Facts and Controversies.
Valeria Castelli, Andrea Lombardi, +7 authors, Andrea Gori.
Cells, 2021 Sep 29; 10(9). PMID: 34571876    Free PMC article.
Review.
The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer.
Ammarina Beumer-Chuwonpad, Renske L R E Taggenbrock, T An Ngo, Klaas P J M van Gisbergen.
Cells, 2021 Sep 29; 10(9). PMID: 34571883    Free PMC article.
Review.
Immune Checkpoints in Cancers: From Signaling to the Clinic.
Céline Pisibon, Amira Ouertani, +2 authors, Yann Cheli.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572799    Free PMC article.
Review.
Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade.
Yasuhiro Kanda, Taku Okazaki, Tomoya Katakai.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572844    Free PMC article.
Review.
Interplay of Immunometabolism and Epithelial-Mesenchymal Transition in the Tumor Microenvironment.
Ming-Yu Chou, Muh-Hwa Yang.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576042    Free PMC article.
Review.
Improving CAR T-Cell Persistence.
Violena Pietrobon, Lauren Anne Todd, +3 authors, Francesco Marincola.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639168    Free PMC article.
Review.
Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial.
Ai Yamaguchi, Izumi Kawagoe, +4 authors, Masakazu Hayashida.
J Thorac Dis, 2021 Oct 19; 13(9). PMID: 34659809    Free PMC article.
Immunotherapy in colorectal cancer: current achievements and future perspective.
Ahui Fan, Boda Wang, +4 authors, Yuanyuan Lu.
Int J Biol Sci, 2021 Oct 22; 17(14). PMID: 34671202    Free PMC article.
Review.
Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
Dunia Garcia Cruz, Raghavendra R Giri, +3 authors, Annabelle Rodriguez.
J Immunol, 2021 Oct 01; 207(9). PMID: 34588222    Free PMC article.
Pulmonary Toxicities Associated With the Use of Immune Checkpoint Inhibitors: An Update From the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer.
Bernardo L Rapoport, Vickie R Shannon, +5 authors, Ronald Anderson.
Front Pharmacol, 2021 Oct 23; 12. PMID: 34675810    Free PMC article.
Review.
Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment.
Nagaja Capitani, Laura Patrussi, Cosima T Baldari.
Int J Mol Sci, 2021 Oct 24; 22(20). PMID: 34681881    Free PMC article.
Review.
Emerging concepts in PD-1 checkpoint biology.
Kristen E Pauken, James A Torchia, +2 authors, Gordon J Freeman.
Semin Immunol, 2021 May 20; 52. PMID: 34006473    Free PMC article.
Review.
Metabolic regulation of the cancer-immunity cycle.
Luis F Somarribas Patterson, Santosha A Vardhana.
Trends Immunol, 2021 Oct 07; 42(11). PMID: 34610889    Free PMC article.
Review.
Engineered Removal of PD-1 From the Surface of CD19 CAR-T Cells Results in Increased Activation and Diminished Survival.
R S Kalinin, V M Ukrainskaya, +9 authors, A V Stepanov.
Front Mol Biosci, 2021 Nov 02; 8. PMID: 34722633    Free PMC article.
Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC.
Shi-Wei Chen, Shu-Qiang Zhu, +7 authors, Yong-Bing Wu.
Mol Cancer, 2021 Nov 11; 20(1). PMID: 34753486    Free PMC article.
CD38 Correlates with an Immunosuppressive Treg Phenotype in Lupus-Prone Mice.
Jocelyn C Pérez-Lara, Enrique Espinosa, +7 authors, Juan C Rodríguez-Alba.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34769406    Free PMC article.
Adjuvant Therapy of Melanoma.
Diwakar Davar, John M Kirkwood.
Cancer Treat Res, 2015 Nov 26; 167. PMID: 26601863    Free PMC article.
Review.
Continuous Modeling of T CD4 Lymphocyte Activation and Function.
David Martínez-Méndez, Luis Mendoza, Carlos Villarreal, Leonor Huerta.
Front Immunol, 2021 Nov 23; 12. PMID: 34804023    Free PMC article.
Molecular and Clinical Characterization of a Novel Prognostic and Immunologic Biomarker GPSM3 in Low-Grade Gliomas.
Ming Wang, Jiaoying Jia, +2 authors, Yugang Jiang.
Brain Sci, 2021 Nov 28; 11(11). PMID: 34827528    Free PMC article.
Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy.
Hyunmin Chung, Haiyoung Jung, Ji-Yoon Noh.
Int J Mol Sci, 2021 Nov 28; 22(22). PMID: 34830003    Free PMC article.
Review.
What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 4: Experimental Treatments in Pre-Clinical Studies (Cell Lines and Mouse Models).
Andrea Palicelli, Stefania Croci, +22 authors, Martina Bonacini.
Int J Mol Sci, 2021 Nov 28; 22(22). PMID: 34830179    Free PMC article.
Systematic Review.
Metabolic interventions: A new insight into the cancer immunotherapy.
Tao Yu, Tianhan Dong, +4 authors, Xiongbin Lu.
Arch Biochem Biophys, 2020 Nov 05; 697. PMID: 33144083    Free PMC article.
Review.
Locally Injectable Hydrogels for Tumor Immunotherapy.
Xinyi Zhang, Xiaonan Guo, Yan Wu, Jie Gao.
Gels, 2021 Nov 30; 7(4). PMID: 34842684    Free PMC article.
Review.
Optimization of metabolism to improve efficacy during CAR-T cell manufacturing.
Meng Zhang, Xin Jin, +4 authors, MingFeng Zhao.
J Transl Med, 2021 Dec 09; 19(1). PMID: 34876185    Free PMC article.
Review.
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response.
Yu-Ting Yen, May Chien, +7 authors, Shih-Chieh Hung.
Nat Commun, 2021 Dec 17; 12(1). PMID: 34911954    Free PMC article.
Nanomedicines in B cell-targeting therapies.
Jiawei Wang, Jiyuan Yang, Jindřich Kopeček.
Acta Biomater, 2021 Oct 24; 137. PMID: 34687954    Free PMC article.
Review.
Contributions of PD-L1 reverse signaling to dendritic cell trafficking.
Beth Ann Jirón Tamburini.
FEBS J, 2021 Jun 20;. PMID: 34146376    Free PMC article.
Long Non-Coding RNAs (lncRNAs) in Response and Resistance to Cancer Immunosurveillance and Immunotherapy.
Giasemi C Eptaminitaki, Nora Wolff, +2 authors, Stavroula Baritaki.
Cells, 2021 Dec 25; 10(12). PMID: 34943820    Free PMC article.
Review.
Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions.
Katrin Pansy, Barbara Uhl, +9 authors, Alexander Ja Deutsch.
Int J Mol Sci, 2021 Dec 25; 22(24). PMID: 34948104    Free PMC article.
Review.
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy.
Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern.
Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146    Free PMC article.
Review.
Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance?
Sultana Mehbuba Hossain, Chiemi F Lynch-Sutherland, +2 authors, Michael R Eccles.
Epigenomes, 2021 Dec 31; 5(3). PMID: 34968365    Free PMC article.
Review.
Pulmonary Toxicities of Immunotherapy.
Mehmet Altan, Linda Zhong, Vickie R Shannon, Ajay Sheshadri.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972974
Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer.
Tamara Mirzapoiazova, Gang Xiao, +18 authors, Ravi Salgia.
Mol Cancer Ther, 2021 Jul 14; 20(10). PMID: 34253596    Free PMC article.
The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance.
Gennie L Parkman, Mona Foth, +2 authors, Martin McMahon.
Exp Dermatol, 2021 Oct 31; 31(1). PMID: 34717019    Free PMC article.
Review.
Emerging Role of PD-1/PD-L1 Inhibitors in Chronic Liver Diseases.
Vishakha Singh, Amit Khurana, +3 authors, Ralf Weiskirchen.
Front Pharmacol, 2022 Jan 11; 12. PMID: 35002724    Free PMC article.
Review.
Case Report: A Case of Sintilimab-Induced Cystitis/Ureteritis and Review of Sintilimab-Related Adverse Events.
Lingfang Tu, Yuan Ye, +4 authors, Zhijie Pan.
Front Oncol, 2022 Jan 11; 11. PMID: 35004277    Free PMC article.
UM171A-induced ROS promote antigen cross-presentation of immunogenic peptides by bone marrow-derived mesenchymal stromal cells.
Natasha Salame, Jean-Pierre Bikorimana, +6 authors, Moutih Rafei.
Stem Cell Res Ther, 2022 Jan 12; 13(1). PMID: 35012668    Free PMC article.
PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism.
Luca Simula, Ylenia Antonucci, +9 authors, Silvia Campello.
Mol Oncol, 2021 Sep 19; 16(1). PMID: 34535949    Free PMC article.
Metabolic Implications of Immune Checkpoint Proteins in Cancer.
Elizabeth R Stirling, Steven M Bronson, +3 authors, David R Soto-Pantoja.
Cells, 2022 Jan 12; 11(1). PMID: 35011741    Free PMC article.
Review.
Modulation of intrinsic inhibitory checkpoints using nano-carriers to unleash NK cell activity.
Guy Biber, Batel Sabag, +7 authors, Mira Barda-Saad.
EMBO Mol Med, 2021 Nov 03; 14(1). PMID: 34725941    Free PMC article.
Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice.
Jamilah Abusarah, Fatemeh Khodayarian, +16 authors, Moutih Rafei.
Cell Rep Med, 2022 Jan 15; 2(12). PMID: 35028603    Free PMC article.
Soluble antigens derived from Coxiella burnetii elicit protective immunity in three animal models without inducing hypersensitivity.
Anthony E Gregory, Erin J van Schaik, +3 authors, James E Samuel.
Cell Rep Med, 2022 Jan 15; 2(12). PMID: 35028605    Free PMC article.
Importance of T, NK, CAR T and CAR NK Cell Metabolic Fitness for Effective Anti-Cancer Therapy: A Continuous Learning Process Allowing the Optimization of T, NK and CAR-Based Anti-Cancer Therapies.
Adrien Krug, Adriana Martinez-Turtos, Els Verhoeyen.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008348    Free PMC article.
Review.
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions.
Ming Yi, Xiaoli Zheng, +3 authors, Kongming Wu.
Mol Cancer, 2022 Jan 23; 21(1). PMID: 35062949    Free PMC article.
Review.
Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms.
Thiago J Borges, Naoka Murakami, +14 authors, Leonardo V Riella.
JCI Insight, 2021 Nov 10; 6(24). PMID: 34752418    Free PMC article.
Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer.
Roberto Corchado-Cobos, Natalia García-Sancha, +8 authors, Jesús Pérez-Losada.
Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053485    Free PMC article.
Review.
Comparison of Anticancer Drug Toxicities: Paradigm Shift in Adverse Effect Profile.
Debasish Basak, Scott Arrighi, Yasenya Darwiche, Subrata Deb.
Life (Basel), 2022 Jan 22; 12(1). PMID: 35054441    Free PMC article.
Review.
New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma.
Wu Yi, Tianxin Yang, +4 authors, Xiangming Tong.
Cancer Manag Res, 2022 Feb 05; 14. PMID: 35115837    Free PMC article.
Review.
PD-L1 combined with HDAC9 is a useful prognostic predictor in hepatocellular carcinoma.
Zhao Yang, Lei Zhang, +4 authors, Kui Wang.
Transl Cancer Res, 2022 Feb 05; 10(5). PMID: 35116547    Free PMC article.
Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker analyses.
Claire F Friedman, Christine Spencer, +17 authors, Jedd Wolchok.
J Immunother Cancer, 2022 Jan 26; 10(1). PMID: 35074903    Free PMC article.
PD1/PD-L1 pathway in psoriasis and psoriatic arthritis: a review.
Michał Adamczyk, Dorota Krasowska.
Postepy Dermatol Alergol, 2022 Feb 08; 38(6). PMID: 35125995    Free PMC article.
Review.
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1.
Yuwei Hao, Matthew C Cook.
Front Immunol, 2022 Feb 15; 12. PMID: 35154081    Free PMC article.
Review.
Characterization of Immunoactive and Immunotolerant CD4+ T Cells in Breast Cancer by Measuring Activity of Signaling Pathways That Determine Immune Cell Function.
Yvonne Wesseling-Rozendaal, Arie van Doorn, Karen Willard-Gallo, Anja van de Stolpe.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158758    Free PMC article.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Progress, Challenges, and Prospects.
Shengjie Tang, Chao Qin, +7 authors, Haining Zhou.
Cells, 2022 Feb 16; 11(3). PMID: 35159131    Free PMC article.
Review.
Inhibitory immune checkpoint molecules and exhaustion of T cells in COVID-19.
M Barnova, A Bobcakova, +4 authors, M Jesenak.
Physiol Res, 2021 Dec 17; 70(S2). PMID: 34913354    Free PMC article.
Review.
mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment.
Sahar Mafi, Behzad Mansoori, +4 authors, Davoud Rostamzadeh.
Front Immunol, 2022 Mar 08; 12. PMID: 35250965    Free PMC article.
Review.
New Immunometabolic Strategy Based on Cell Type-Specific Metabolic Reprogramming in the Tumor Immune Microenvironment.
Ji-Yong Sung, Jae-Ho Cheong.
Cells, 2022 Mar 11; 11(5). PMID: 35269390    Free PMC article.
Review.
Immunogenetics of Lupus Erythematosus.
Begüm Ünlü, Ümit Türsen, +2 authors, Fateme Rajabi.
Adv Exp Med Biol, 2022 Mar 15; 1367. PMID: 35286698
Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy.
Michael P Vincent, Justin O Navidzadeh, Sharan Bobbala, Evan A Scott.
Cancer Cell, 2022 Feb 13; 40(3). PMID: 35148814    Free PMC article.
Review.
Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS.
Maja Machcińska, Magdalena Kierasińska, +6 authors, Katarzyna Donskow-Łysoniewska.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328606    Free PMC article.
Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies.
Hao-Tian Wu, Xiang-Yu Zhao.
Int J Biol Sci, 2022 Mar 29; 18(5). PMID: 35342342    Free PMC article.
Review.
Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells.
Yue Huang, Xiaohui Si, +3 authors, He Huang.
J Hematol Oncol, 2022 Mar 30; 15(1). PMID: 35346311    Free PMC article.
Review.
Effects of PD-1 Signaling on Immunometabolic Reprogramming.
Vassiliki A Boussiotis, Nikolaos Patsoukis.
Immunometabolism, 2022 Apr 05; 4(2). PMID: 35371563    Free PMC article.
Immunotherapy Combined With Chemotherapy for Postoperative Recurrent Penile Squamous Cell Carcinoma: A Case Report and Literature Review.
Na Li, Tangpeng Xu, +3 authors, Xiangpan Li.
Front Oncol, 2022 Apr 12; 12. PMID: 35402270    Free PMC article.
Immune Checkpoint Receptors Signaling in T Cells.
Gianluca Baldanzi.
Int J Mol Sci, 2022 Apr 13; 23(7). PMID: 35408889    Free PMC article.
Review.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
Review.
A phase I/II trial of concurrent immunotherapy with chemoradiation in locally advanced larynx cancer.
Andrew J Frankart, Nooshin Hashemi Sadraei, +8 authors, Vinita Takiar.
Laryngoscope Investig Otolaryngol, 2022 Apr 19; 7(2). PMID: 35434343    Free PMC article.
PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection.
Joseph A Perry, Lindsey Shallberg, +16 authors, Christopher A Hunter.
Nat Immunol, 2022 Apr 20; 23(5). PMID: 35437326    Free PMC article.
Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity.
Shu Wu, Yuanlong Ge, +6 authors, Zhenyu Ju.
Nucleic Acids Res, 2022 Mar 25; 50(7). PMID: 35323972    Free PMC article.
Impact of Drp1-Mediated Mitochondrial Dynamics on T Cell Immune Modulation.
Jun Song, Xiaofang Yi, +6 authors, Jietao Ma.
Front Immunol, 2022 Apr 19; 13. PMID: 35432303    Free PMC article.
Review.
The Role of Metabolic Dysfunction in T-Cell Exhaustion During Chronic Viral Infection.
Kehong Zheng, Xiaojun Zheng, Wei Yang.
Front Immunol, 2022 Apr 19; 13. PMID: 35432304    Free PMC article.
Review.
Mechanism of resistance to immune checkpoint inhibitors.
Manu R Pandey, Marc S Ernstoff.
Cancer Drug Resist, 2019 Jun 19; 2(2). PMID: 35582715    Free PMC article.
Review.
Signal pathways and precision therapy of small-cell lung cancer.
Min Yuan, Yu Zhao, +3 authors, Qing Xu.
Signal Transduct Target Ther, 2022 Jun 16; 7(1). PMID: 35705538
Review.