Review
. 2005 Dec; 143(12):895-904.
doi: 10.7326/0003-4819-143-12-200512200-00007.

New concepts in the pathophysiology of inflammatory bowel disease

Giorgos Bamias 1 Mark R Nyce  Sarah A De La Rue  Fabio Cominelli  American College of Physicians  American Physiological Society  
Affiliations
  • PMID: 16365470
  •     44 citations

No abstract available

Probiotics and prebiotics in chronic inflammatory bowel diseases.
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World J Gastroenterol, 2006 Sep 30; 12(37). PMID: 17009391    Free PMC article.
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Efficacy of infliximab for luminal and fistulizing Crohn's disease and in ulcerative colitis.
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Curr Treat Options Gastroenterol, 2007 Jun 06; 10(3). PMID: 17547855
Induction of experimental acute ulcerative colitis in rats by administration of dextran sulfate sodium at low concentration followed by intracolonic administration of 30% ethanol.
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J Zhejiang Univ Sci B, 2007 Aug 30; 8(9). PMID: 17726744    Free PMC article.
TNFalpha blockade prevents the development of inflammatory bowel disease in HLA-B27 transgenic rats.
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J Cell Mol Med, 2008 Mar 28; 13(1). PMID: 18363845    Free PMC article.
Innate and adaptive immune responses related to IBD pathogenesis.
Kristen O Arseneau, Hiroshi Tamagawa, Theresa T Pizarro, Fabio Cominelli.
Curr Gastroenterol Rep, 2008 Apr 02; 9(6). PMID: 18377804
Review.
Prebiotics in chronic intestinal inflammation.
Mirjam A C Looijer-van Langen, Levinus A Dieleman.
Inflamm Bowel Dis, 2008 Oct 04; 15(3). PMID: 18831524    Free PMC article.
Review.
The epidemiology and pathogenesis of neoplasia in the small intestine.
David Schottenfeld, Jennifer L Beebe-Dimmer, Fawn D Vigneau.
Ann Epidemiol, 2008 Dec 10; 19(1). PMID: 19064190    Free PMC article.
Review.
The serum D-xylose test as a useful tool to identify malabsorption in rats with antigen specific gut inflammatory reaction.
Danielle Mota Fontes Antunes, Janilda Pacheco da Costa, +5 authors, Gilberto Perez Cardoso.
Int J Exp Pathol, 2009 Apr 02; 90(2). PMID: 19335552    Free PMC article.
Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease.
Carsten Gnewuch, Gerhard Liebisch, +8 authors, Gerd Schmitz.
World J Gastroenterol, 2009 Jul 04; 15(25). PMID: 19575493    Free PMC article.
Cancer antigen 125 levels in inflammatory bowel diseases.
Hilmi Ataseven, Zeynel Abidin Oztürk, +6 authors, Ilhami Yüksel.
J Clin Lab Anal, 2009 Jul 23; 23(4). PMID: 19623645    Free PMC article.
Frequency of single nucleotide polymorphisms in NOD1 gene of ulcerative colitis patients: a case-control study in the Indian population.
Ravi Verma, Vineet Ahuja, Jaishree Paul.
BMC Med Genet, 2009 Sep 03; 10. PMID: 19723304    Free PMC article.
Probiotics promote gut health through stimulation of epithelial innate immunity.
Cristiano Pagnini, Rubina Saeed, +3 authors, Fabio Cominelli.
Proc Natl Acad Sci U S A, 2009 Dec 19; 107(1). PMID: 20018654    Free PMC article.
Highly Cited.
Role of the gut-associated and secondary lymphoid tissue in the induction of chronic colitis.
Koichi Takebayashi, Iurii Koboziev, +7 authors, Matthew B Grisham.
Inflamm Bowel Dis, 2010 Sep 03; 17(1). PMID: 20812332    Free PMC article.
Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis.
Xuan-Zheng Shi, John H Winston, Sushil K Sarna.
Am J Physiol Gastrointest Liver Physiol, 2010 Oct 16; 300(1). PMID: 20947704    Free PMC article.
Recent advances in cytokines: therapeutic implications for inflammatory bowel diseases.
Guillaume Bouguen, Jean-Baptiste Chevaux, Laurent Peyrin-Biroulet.
World J Gastroenterol, 2011 Feb 26; 17(5). PMID: 21350703    Free PMC article.
Review.
NaOH-induced Crohn's colitis in rats: a novel experimental model.
Erdem Koçak, Seyfettin Köklü, +5 authors, Murat Can.
Dig Dis Sci, 2011 Apr 20; 56(10). PMID: 21503680
SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis.
Theresa T Pizarro, Luca Pastorelli, +7 authors, Fabio Cominelli.
Inflamm Bowel Dis, 2011 May 11; 17(12). PMID: 21557393    Free PMC article.
Review.
In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp.
Louise Kristine Vigsnæs, Jesper Holck, Anne S Meyer, Tine Rask Licht.
Appl Environ Microbiol, 2011 Oct 11; 77(23). PMID: 21984234    Free PMC article.
Role of LFA-1 in the activation and trafficking of T cells: implications in the induction of chronic colitis.
Iurii Koboziev, Fridrik Karlsson, +4 authors, Matthew B Grisham.
Inflamm Bowel Dis, 2012 Apr 11; 18(12). PMID: 22488891    Free PMC article.
Probiotics for the treatment of inflammatory bowel disease.
Ganesh R Veerappan, John Betteridge, Patrick E Young.
Curr Gastroenterol Rep, 2012 May 15; 14(4). PMID: 22581276
Review.
The mRNA level of the transforming growth factor β1 gene, but not the amount of the gene product, can be considered as a potential prognostic parameter in inflammatory bowel diseases in children.
Anna Liberek, Zbigniew Kmieć, +11 authors, Grzegorz Węgrzyn.
Int J Colorectal Dis, 2012 May 16; 28(2). PMID: 22584294    Free PMC article.
Respiratory involvement in inflammatory bowel diseases.
Nadia D'Andrea, Rossana Vigliarolo, Claudio M Sanguinetti.
Multidiscip Respir Med, 2010 Jan 01; 5(3). PMID: 22958334    Free PMC article.
Changes of the cytokine profile in inflammatory bowel diseases.
Györgyi Műzes, Béla Molnár, Zsolt Tulassay, Ferenc Sipos.
World J Gastroenterol, 2012 Nov 10; 18(41). PMID: 23139600    Free PMC article.
Review.
Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease.
Rebeca Martín, Sylvie Miquel, +3 authors, Luis G Bermúdez-Humarán.
Microb Cell Fact, 2013 Jul 24; 12. PMID: 23876056    Free PMC article.
Review.
Intestinal-specific TNFα overexpression induces Crohn's-like ileitis in mice.
Giorgos Bamias, Mohamed I Dahman, +4 authors, Fabio Cominelli.
PLoS One, 2013 Aug 27; 8(8). PMID: 23977323    Free PMC article.
Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis.
Martina Galatola, Erasmo Miele, +9 authors, Marina De Rosa.
World J Gastroenterol, 2014 Jan 01; 19(46). PMID: 24379584    Free PMC article.
Interactions between the intestinal microbiota and innate lymphoid cells.
Vincent L Chen, Dennis L Kasper.
Gut Microbes, 2014 Jan 15; 5(1). PMID: 24418741    Free PMC article.
Review.
Probiotic yogurt Affects Pro- and Anti-inflammatory Factors in Patients with Inflammatory Bowel Disease.
Mahdi Shadnoush, Rahebeh Shaker Hosseini, +5 authors, Jalal Zaringhalam Moghadam.
Iran J Pharm Res, 2014 Feb 14; 12(4). PMID: 24523774    Free PMC article.
Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease.
Zi-Kai Wang, Yun-Sheng Yang, +3 authors, Li-Hua Peng.
World J Gastroenterol, 2014 Oct 31; 20(40). PMID: 25356041    Free PMC article.
Review.
Circulating ghrelin levels and obestatin/ghrelin ratio as a marker of activity in ulcerative colitis.
Ja Young Jung, Ji Bong Jeong, +4 authors, Kook Lae Lee.
Intest Res, 2015 Feb 19; 13(1). PMID: 25691845    Free PMC article.
Association of familial Mediterranean fever in Turkish children with inflammatory bowel disease.
Ömer Faruk Beşer, Fügen Çullu Çokuğraş, +4 authors, Tülay Erkan.
Turk Pediatri Ars, 2015 Jun 17; 49(3). PMID: 26078663    Free PMC article.
Pathway-based approaches to the treatment of inflammatory bowel disease.
Giorgos Bamias, Theresa T Pizarro, Fabio Cominelli.
Transl Res, 2015 Sep 27; 167(1). PMID: 26408803    Free PMC article.
Review.
A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection.
Li-Guo Jia, Giorgos Bamias, +5 authors, Fabio Cominelli.
J Immunol, 2016 May 29; 197(1). PMID: 27233964    Free PMC article.
Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability and Stool Concentrations of Zonulin in Athletes.
Maciej Hałasa, Dominika Maciejewska, +3 authors, Ewa Stachowska.
Nutrients, 2017 Apr 12; 9(4). PMID: 28397754    Free PMC article.
Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease.
Qingdong Guan, Jiguo Zhang.
Mediators Inflamm, 2017 Apr 20; 2017. PMID: 28420941    Free PMC article.
Review.
Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation.
Zhao-Hua Shen, Chang-Xin Zhu, +5 authors, Xiao-Yan Wang.
World J Gastroenterol, 2018 Jan 24; 24(1). PMID: 29358877    Free PMC article.
Review.
Healthcare utilisation prior to the diagnosis of inflammatory bowel diseases and the influence of livestock exposure: A longitudinal case-control study.
Baukje J van der Star, Christel E van Dijk, +4 authors, C Joris Yzermans.
PLoS One, 2018 Apr 10; 13(4). PMID: 29630633    Free PMC article.
A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease.
Qingdong Guan.
J Immunol Res, 2019 Dec 31; 2019. PMID: 31886308    Free PMC article.
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The Potential of Mesenchymal Stem Cells to Treat Systemic Inflammation in Horses.
Elizabeth S MacDonald, Jennifer G Barrett.
Front Vet Sci, 2020 Feb 11; 6. PMID: 32039250    Free PMC article.
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Impairment of electroneutral Na+ transport and associated downregulation of NHE3 contributes to the development of diarrhea following in vivo challenge with Brachyspira spp.
Cole B Enns, Brandon A Keith, +2 authors, Matthew E Loewen.
Am J Physiol Gastrointest Liver Physiol, 2019 Nov 26; 318(2). PMID: 31760765    Free PMC article.
Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn's Disease.
Ludovica F Buttó, Li-Guo Jia, +7 authors, Fabio Cominelli.
Inflamm Bowel Dis, 2018 Oct 09; 25(1). PMID: 30295722    Free PMC article.
Revisiting Inflammatory Bowel Disease: Pathology, Treatments, Challenges and Emerging Therapeutics Including Drug Leads from Natural Products.
Karma Yeshi, Roland Ruscher, +3 authors, Phurpa Wangchuk.
J Clin Med, 2020 May 02; 9(5). PMID: 32354192    Free PMC article.
Review.
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Jing-Lin Liu, Chu-Yi Wang, +8 authors, Jian-Ming Li.
Cell Mol Gastroenterol Hepatol, 2021 Mar 03; 12(1). PMID: 33652118    Free PMC article.
Systems biology approach highlights mechanistic differences between Crohn's disease and ulcerative colitis.
Pedro A Ruiz Castro, Hasmik Yepiskoposyan, +6 authors, Marja Talikka.
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